Findacure has found an innovative way to use this financial tool to fund drug repurposing research for rare diseases. This is the rare disease drug repurposing social impact bond - RDDR SIB for short.. But how would it work?. Our SIB is based on the premise that successfully repurposing low cost generic drugs for rare disease patients will save the NHS money. Rare diseases left untreated cost the NHS lots in surgery, care, appointments, hospital, stays, and much more - a cost that can be significantly reduced by a cheap, repurposed treatment. The NHS can then use a portion of these savings to reimburse Findacure for the cost of the clinical trial. We will use this reimbursement to pay back private investors, whose money was required to initially run the trial. Surplus reimbursement will be invested by us in more clinical trials: the project is self-sustaining and non-profit.. ...

TY - GEN. T1 - Seed-based hemodynamic connectivity mapping to analyze the effect of hemi-Parkinsons disease using NIR Imaging. AU - Paik, Seung Ho. AU - Erdogan, Sedef. AU - Phillips, V. Zephaniah. AU - Kim, Young Kyu. AU - Song, Kang Il. AU - Park, Sunghee Estelle. AU - Choi, Youngwoon. AU - Youn, Inchan. AU - Kim, Beop-Min. PY - 2018/8/6. Y1 - 2018/8/6. N2 - A single camera near infrared hemodynamic imaging system was developed to analyze the effects hemi-Parkinsons disease on the functional organization of the brain using seed-based connectivity mapping during resting state.. AB - A single camera near infrared hemodynamic imaging system was developed to analyze the effects hemi-Parkinsons disease on the functional organization of the brain using seed-based connectivity mapping during resting state.. UR - http://www.scopus.com/inward/record.url?scp=85052585072&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85052585072&partnerID=8YFLogxK. M3 - Conference ...

A novel machine-learning technique leverages gene expression data to improve drug repurposing and can even predict new associations based on incomplete data.

Along the lines that have been discussed in a recent Frontiers short paper, here is a list of our patent discussions in the December 2017 drug repurposing special issue of ASSAY and Drug Development Technologies:. WO/2017/059389 (Kythera Biopharmaceuticals, USA): Statins as an alternative to liposuction and cryolipolysis. WO/2017/060308 (AB Science, France): Masitinib switches to human use. WO/2017/066421 (Ovid Therapeutics, USA): Eplivanserin for improving cognition in psychoses. WO/2017/068143 (Individual, Germany): BAY 11-7082 or dimethyl fumarate for adiposity or cardiovascular diseases. WO/2017/080919 (Freiburg University, Germany): Roflumilast for metabolic lipid disorders. WO/2017/081609 (Individuals): Febuxostat: from gout to neurology. WO/2017/085407 (Pierre et Marie Curie University et al., France): Mirabegron, an overactive bladder drug, for macular degeneration. WO/2017/091644 (AZ Therapies, USA): Cromolyn for cerebral ischemia and dementia. WO/2017/096013 (Cornell University, USA): ...

Drug repurposing or re-profiling has been the hallmark to bring strong business growth and the trend is being followed by majority of the pharmaceutical an

Market research report on drug repurposing service provides with a focus on current market landscape and future growth opportunities

1. Probably the most famous repurposing case is that of thalidomide. First used as a sedative in the 1950s thalidomide is infamous for causing birth defects in babies of women who were prescribed it to treat nausea whilst pregnant. It was, however, successfully and safely repurposed in 1998 to treat leprosy and in 2006 to treat the blood cancer multiple myeloma.. 2. Discovered in 1972 on Easter Island, rapamycin, also known as Sirolimus, is produced by a soil bacterium Streptomyces hygroscopicus. Its ability to suppress the immune system led to its original approved use to prevent rejection in organ transplantation in 1999. It has since been successfully repurposed to treat two rare diseases, autoimmune lymphoproliferative syndrome (ALPS) and lymphangioleiomyomatosis, a lung disease.. 3. Lomitapide was originally used to lower cholesterol and triglycerides. It went on to be approved in 2012 by the Food and Drug Administration (FDA) and in 2013 by the European Commission to treat patients with ...

Prosarix Ltd provides computational drug discovery to partner companies and generates preclinical development compounds for out-licensing utilising its proprietary ProtoDiscovery platform.

Schrodinger is hiring a Senior Computational Drug Discovery Scientist, with an estimated salary of $80000 - $100000. This Life Sciences job in Science & Education is in Portland, OR 97201.

Title:Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease. VOLUME: 22 ISSUE: 21. Author(s):V. Joachim Haupt, Jesús E. Aguilar Uvalle, Sebastian Salentin, Simone Daminelli, Franziska Leonhardt, Janez Konc and Michael Schroeder. Affiliation:BIOTEC, TU Dresden, Tatzberg 47/49, 01307 Dresden, Germany.. Keywords:Drug repositioning, drug re-purposing, structural bioinformatics, structure alignment, drug discovery, Chagas disease, target hopping.. Abstract:Background: Drug repositioning aims to identify novel indications for existing drugs. One approach to repositioning exploits shared binding sites between the drug targets and other proteins. Here, we review the principle and algorithms of such target hopping and illustrate them in Chagas disease, an in Latin America widely spread, but neglected disease. Conclusion: We demonstrate how target hopping recovers known treatments for Chagas disease and predicts novel drugs, such as the antiviral foscarnet, which we predict to ...

17.10.17 Postdoctoral position in Computational Drug Design, Computational Chemistry List, Resource for Computational Chemists, molecular modeling, and associated archives

Drawer Repurposed To Bathroom Wall Cabinet {Tutorial, jenson curved single vanity 116cm marble top. Drawer Repurposed To Bathroom Wall Cabinet {Tutorial. irinadorofeeva.com. /

Here we identify hundreds of new drug-disease associations for over 900 FDA-approved drugs by quantifying the network proximity of disease genes and drug targets in the human (protein-protein) interactome. We select four network-predicted associations to test their causal relationship using large healthcare databases with over 220 million patients and state-of-the-art pharmacoepidemiologic analyses. Using propensity score matching, two of four network-based predictions are validated in patient-level data: carbamazepine is associated with an increased risk of coronary artery disease (CAD) [hazard ratio (HR) 1.56, 95% confidence interval (CI) 1.12-2.18], and hydroxychloroquine is associated with a decreased risk of CAD (HR 0.76, 95% CI 0.59-0.97). In vitro experiments show that hydroxychloroquine attenuates pro-inflammatory cytokine-mediated activation in human aortic endothelial cells, supporting mechanistically its potential beneficial effect in CAD. In summary, we demonstrate that a unique ...

8. Surg Neurol 1979; 12367. 56в58,60 These failure rates are likely higher because the tumor propranolol clorhidrato tableta can fall within the area beyond the radiation dose fall-off. Propranolol drug indication T, Habib E, Mekkaoui M, Brassier D, Elhadad Indiccation (2002) Laparoscopic tension-free repair propranolol drug indication anterior abdominal wall incisional and ventral hernias with an intraperitoneal Gore- Tex mesh prospective study and review of the literature.

The worlds growing knowledge of the virology and clinical presentation of COVID-19 has widened the pool of pharmacological targets. In particular, it has increased interest in drug repurposing to either inhibit SARS-CoV-2 replication or to counteract the effects of a massive cytokine release that causes acute respiratory distress syndrome (ARDS) and coagulopathy. (See Janet Sultana, Challenges for Drug Repurposing in the covid-19 Pandemic Era. Front. Pharmacol., 06 November 2020 , https://doi.org/10.3389/fphar.2020.588654). Geneva based Relief Therapeutics has repurposed aviptadil, a vasoactive intestinal polypeptide (VIP) analog with a 20-year history of safe use in humans in multiple human trials for sarcoidosis, pulmonary fibrosis, asthma/allergy, and pulmonary hypertension. In November 2020, the drug was granted FDA Fast Track Designation, FDA emergency use IND authorization, and an expanded access protocol for the treatment of Respiratory Distress Syndrome (ARDS).. Zurich based Metripharm ...

Insilico Medicine will present its recent advances in applying deep learning techniques to drug discovery and repurposing at the Strategic Partnerships in Drug Repurposing conference in Boston taking place at the Wyndham Boston Beacon Hill Oct. 27-28.

Victoza is a core molecule of Novo Nordisk and almost contribute about 25% of the companys total diabetes care revenues. Victoza sales shot up 21% to DKK 11.5 billion ($1.7 billion) in the first half of 2017 compared to the same period the year prior.. Clinical Trial for New Indication Approval:. Victozas new indication is based on data from the late-stage LEADER trial that enrolled more than 9,300 type 2 diabetes who were at high risk of major adverse CV events. Patients receiving Novos drug had an average 13% reduction in their risk of a three-component endpoint that included heart attack, stroke and CV death compared to placebo.. Future Growth or Focus area for the brand:. ...

The search for additional indications for modafinil naturally focused on diseases associated with wake deficits and somnolence. The effects of the drug in an animal model of sleep-disordered breathing suggested that modafinil might be effective in reducing sleepiness associated with sleep apnea,50 and this was subsequently demonstrated in the clinic.51-53 Other disorders where somnolence or sedation was concomitant with the disease, e.g., Parkinsons disease,54-56 myotonic dystrophy,57-60 fibromyalgia,61 amyotrophic lateral sclerosis,62 multiple sclerosis,63 cerebral lymphoma,64 or resulting from the side-effects of other medications such as antidepressants,65 antipsychotics,66 dopaminergic D2 agonists,67,68 opioids,69 or valproic acid,70 have also proven to be amenable to treatment with modafinil.. Likewise modafinil has been applied with equal success to treating the fatigue coexisting with other serious diseases, including multiple sclerosis,71,72 pain,73 and acquired immunodeficiency ...

Forward-Looking Statements Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements include statements about the advancement, therapeutic indication and use, safety, efficacy, tolerability, mechanism of action and potential of lorcaserin; the significance of the PWG s re-adjudication and the CSF study, including the potential use of the results; the response to the CRL for the lorcaserin NDA, including related plans, activities and timing; the therapeutic indication of APD811; and Arena s views, focus, goals, strategy, research and development programs, and ability to develop compounds and commercialize drugs. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena s expectations. Factors that could cause actual results to differ materially from the forward-looking statements include, but are ...

Cerebral palsy (CP) is the most common developmental disability amongst children in the United States, and encompasses a heterogenous group of motor impairment syndromes caused by a non-progressive lesion of the brain. The cause is typically unknown, and the lesion can arise either pre-natally, peri-natally or post-natally. Patients can have mild functional impairments or severely limited mobility and motor control. Many patients have spasticity and hypertonia. CP is a long-term chronic medical condition that requires long-term supportive care services as well as physiotherapy and occupational therapy. In the US, approximately 764,000 children and adults are living with CP, and it is estimated another 8,000-10,000 babies develop CP each year.. ...

The Ilizarov fixator is indicated for trauma induced conditions involving the upper and lower limbs and in all conditions in which mechanical trans-skeletal traction is necessary, such as in comminuted and multi-fragmented fractures, even with loss of bone substance. By avoiding long hospital stays and joint complications resulting from immobilisation, this technique allows a patient to resume his or her usual activities within a few days, with minimum impediment due in the main to the size of the fixator.. ...

Bourne and his colleagues screened 274 drugs approved for human use against 1730 TB proteins with known structures (about 40 percent of the proteome). They reported their results in the November 4 issue of PLoS Computational Biology.. Starting with 274 approved drugs that had been co-crystallized with at least one human or animal protein-a total of 962 drug-receptor complexes-Bourne and his team narrowed the search space further using an algorithm called SOIPPA (Sequence Order Independent Profile-Profile Alignment Algorithm), which was developed by Bourne and Lei Xie, PhD, research scientist at UCSD. For each drug-receptor complex, SOIPPA searched for TB proteins with structurally similar binding sites. Then Bournes team virtually docked the drug into these TB proteins to look for matches.. Theres a computer cost associated with our method, but you can do a whole pathogen proteome on a 100-node cluster in a couple of weeks, Bourne says.. They connected 123 drugs to 447 TB proteins, and ...

During this seemingly endless period of economic stagnation, repurpose has emerged as the word of the decade. Repurpose is omnipresent. My wife recently repurposed a duvet that our dog had chewed by patching the hole and stuffing it into a new cover she made from some leftover fabric from a long-forgotten sewing project. Angus Lotens recent WSJ article, When Cost Cuts Fail… Drastic Measures, tells the tale of small businesses repurposing their entire business model to stay afloat. It seems we are all repurposing: in some cases voluntarily, like my wife who enjoys interior design, and in more cases involuntarily, like the businesses in the WSJ story and the many unfortunate workers who are being repurposed into consumers at food pantries and human services providers by long-term unemployment.. In many ways (consider this another free proposal transition phrase), nonprofits are really small businesses, even if they are run by True Believers. Like small business, nonprofits have formal or ...

http://ift.tt/eA8V8J. The northern hemispheres summer is ending and that is definitely bad news. The good news is that this was not a silly season in health and healthcare research.. Heres the best and worst news of the summer.. The best. Drug repurposing screening reveals possible candidates for anti-Zika therapy. Developing a new drug is a long process, but the Zika virus outbreak has created a global health emergency and a pressing need for therapies that is incompatible with the timings of drug development. This led to a major study published in Nature Medicine in which over 6,000 compounds were screened for possible drug repurposing, including approved drugs, clinical trial drug candidates and pharmacologically active compounds. This screening allowed the identification of compounds that were able to inhibit Zika infection, suppress the effects of infection in neurons, or inhibit viral replication. Furthermore, combination treatments using neuroprotective and antiviral compounds showed a ...

Biovista Vizit is a visual exploration tool for biomedical literature based on NCBI PubMed. Vizit allows scientists to search and explore a biomedical domain, such as a disease, a pathway or a gene, and to create biomedical networks and graphs.

Nearly all the genes in human DNA have two copies, one inherited from the mother and one from the father. There are some genetic diseases where only one copy is normal and the other one is non-functional due to a mistake in the DNA. The idea behind this study was to see if the normal copy can be enhanced to make up for the non-functional copy, said Ali Djalilian, UIC professor of ophthalmology and corresponding author of the paper. Researchers used a mouse model of the human disease aniridia, an eye disorder that affects the iris and causes substantial visual impairment and can also be associated with systemic abnormalities. In aniridia, one copy of the gene PAX6 is normal and the other copy is non-functional. The PAX6 gene is important in eye development and patients with aniridia and PAX6 deficiency are born with eye problems, which limit their vision and can progress throughout life, Djalilian said. The investigators screened drugs that can enhance PAX6 and found a particular class of drugs ...

A Wyss Institute-led collaboration spanning four research labs and hundreds of miles has used the Institutes organ-on-a-chip (Organ Chip) technology to

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Congenital abnormalities of the cardiovascular system are defects that are present at birth. They can occur as a result of genetic defects, environmental conditions, infections, poisoning, medication taken...

ALL-CAUSE MORTALITY AMONG PATIENTS TREATED WITH REPURPOSED ANTIVIRALS AND ANTIBIOTICS FOR COVID-19 IN MEXICO CITY: A REAL-WORLD OBSERVATIONAL ...

This team repurposed e-waste to help minimize the high number of power outages in hospitals in Africa. This effort supports a number of goals outlined by the UN relative to health care, as well as the effort of developing a global partnership to promote development in this area. Kimberly Bawden

Stack em by the bunch or wear one solo!. These lovely THIN cuff bangle bracelets were created from repurposed brass or silver plated serving trays.. The tray is carefully cut with a jewelers saw then sanded, filed and shaped and stamped with a meaningful phrase. Patina or a final polish as needed and a clear seal to help minimize tarnish ...

TY - JOUR. T1 - Exportin Crm1 is repurposed as a docking protein to generate microtubule organizing centers at the nuclear pore. AU - Bao, Xun X. AU - Spanos, Christos. AU - Kojidani, Tomoko. AU - Lynch, Eric M. AU - Rappsilber, Juri. AU - Hiraoka, Yasushi. AU - Haraguchi, Tokuko. AU - Sawin, Kenneth E. N1 - © 2018, Bao et al.. PY - 2018/5/29. Y1 - 2018/5/29. N2 - Non-centrosomal microtubule organizing centers (MTOCs) are important for microtubule organization in many cell types. In fission yeast Schizosaccharomyces pombe, the protein Mto1, together with partner protein Mto2 (Mto1/2 complex), recruits the g-tubulin complex to multiple non-centrosomal MTOCs, including the nuclear envelope (NE). Here, we develop a comparative-interactome mass spectrometry approach to determine how Mto1 localizes to the NE. Surprisingly, we find that Mto1, a constitutively cytoplasmic protein, docks at nuclear pore complexes (NPCs), via interaction with exportin Crm1 and cytoplasmic FG-nucleoporin Nup146. Although ...

Pamela Hovland, who always has her eyes WIDE OPEN to what is around her, sent us this photo from a recent trip to Minnesota: an old swing set repurposed

Peripheral arterial disease (PAD) results from atherosclerosis that leads to blocked arteries and reduced blood flow, most commonly in the arteries of the legs. PAD clinical trials to induce angiogenesis to improve blood flow conducted in the last decade have not succeeded. We have recently constructed PADPIN, protein-protein interaction network (PIN) of PAD, and here we combine it with the drug-target relations to identify potential drug targets for PAD. Specifically, the proteins in the PADPIN were classified as belonging to the angiome, immunome, and arteriome, characterizing the processes of angiogenesis, immune response/inflammation, and arteriogenesis, respectively. Using the network-based approach we predict the candidate drugs for repositioning that have potential applications to PAD. By compiling the drug information in two drug databases DrugBank and PharmGKB, we predict FDA-approved drugs whose targets are the proteins annotated as anti-angiogenic and pro-inflammatory, respectively. Examples

I have often talked of repurposing as being key to creativity, particularly for teachers using new technologies. (See previous postings on this topic here and here, and here and here.) Imagine my surprise when this past Sundays comics-page had a comic on this very issue. The strip is called Jump Start below is the specific set of panels on repurposing.. ...

I recently watched Bag It: The Movie & found myself horrified by the sheer amount of stuff we throw out every day. I mean, I knew that there is a waste problem in this culture, but to see it quantified kind of made my stomach turn. I took a lot of things away from that movie, but one thing in particular was the idea of repurposing things. Sure, recycling is grand, but it still takes quite a bit of energy to run recycling centers. Giving something new life as something else should be step number one.. I had no idea that there are so many great ideas out there for putting old, tired, or used things to new uses. Dummies.com has a short list on how to reuse or repurpose things around the house. Gomestic gets creative with upcycling household objects including corks, tea bags, pantyhose, & old headboards. Frugal Village also has some great ideas such as creating gift bows from magazine strips. And of course I cant pass up this fabulous post at DIY Life on what you can do with old bedsheets. ...

SOM Biotech (SOM), a leading drug repurposing company based in Barcelona, Spain , has determined and validated an entirely new usage for Nippon Chemiphars marketed hypertension

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FDA Grants Priority Review for Potential New Indication for Lillys Verzenio(TM) (abemaciclib) as Initial Treatment of Advanced Breast Cancer

The current standard of care for the treatment of venous thromboembolism (VTE), including DVT and pulmonary embolism, is low molecular weight heparin injections followed by a vitamin K antagonist, such as warfarin, these are also used as standard therapy for stroke prevention in atrial fibrillation. Heparins require administration by injection, which can cause inconvenience and discomfort. Vitamin K antagonists can be difficult to manage with regularly changing doses and many interactions with food and other drugs among their limitations.. Rivaroxaban has the potential to replace the dual-drug approach in deep vein thrombosis treatment with a single-drug approach that can potentially simplify the patient pathway and improve efficiencies in delivering treatment to patients in need.. Approval by the European Committe in these new indications is expected to follow in the fourth quarter of 2011.. Patients have waited over 50 years for new treatments which offer an alternative to traditional ...

As EuroPCR 2012 gets under way today, Medtronic, Inc. (NYSE: MDT) announced that the Resolute Integrity Coronary Stent System has received European regulatory approval for several new indications, making it the ......MDT

[New indications for transcranial Doppler--huge steps forward].: Huge steps forward in understanding and treatment of ischemic stroke happened in the last sever

Bayer registered a new indication for rivaroxaban for use in patients with coronary heart disease or peripheral artery disease in the European Union and USA

Cambridge, UK, September 3rd 2010 - Prosarix announces successful completed of EEDA funded program on the development of chiral SAR panels for drug discovery.. Pharmaceutical companies develop biologically active lead compounds using a variety of methods e.g. rational approaches (fragment-based discovery, computer-based design) or screening large collections of molecules (HTS - high throughput screening). From an identified hit, large numbers of structurally-related compounds are synthesised in order to optimise both the drug-like properties of the molecule and to define the maximum scope of protectable IP.. A recent trend by companies working in this structure activity relationship (SAR) stage of drug discovery is to utilise more complex molecular structures, which typically possess chirality, i.e. the compound can exist in two or more stereospecific forms. As a consequence single isomers are now preferred as building blocks for use during construction of SAR compound series, even at the ...

I think this is a very promising development for the applications of computation to drug discovery, but as a scientist in the field myself I am even more excited about the volume of useful data this effort must have generated. This is simply because, based on their model, it seems that every molecule that Nimbus prioritizes or discards necessarily goes through their computational pipeline: this would be rather unique. The corpus of data this process generates is presumably locked inside Nimbuss virtual vaults, but I think they and Schrodinger should release at least a high level abstraction of it to let everyone figure out what worked and what did not. At the very least it would transform Nimbuss success from an impressive black box to a comprehensible landscape of computational workflows. ...

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The acquisition of a Blue Gene/Q from IBM (the fastest supercomputer in Canada) has propelled the institute into becoming a leader in using artificial intelligence (AI) for computational drug design. Using this large power processing capability and with the help of highly qualified computer modellers, the AVI has created a successful computational drug discovery centre that allows researchers to execute inexpensive high-speed in silico screening of billions of chemicals as potential therapeutic drugs.. The AVI has developed a strong partnership with the University of Albertas Alberta Cell Therapy Manufacturing (ACTM) facility. This relationship allows for the manufacturing of the AVIs HCV vaccine under GMP standards in preparation for clinical trials. Together with our industry-experienced personnel, this association between the ACTM and the AVI provides the latter with the ability to produce high quality biological products from mammalian cells for human use. This capacity is unique and ...

Developing novel uses of approved drugs, called drug repositioning, can reduce costs and times in traditional drug development. Network-based approaches have presented promising results in this field. However, even though various types of interactions such as activation or inhibition exist in drug-target interactions and molecular pathways, most of previous network-based studies disregarded this information. We developed a novel computational method, Prediction of Drugs having Opposite effects on Disease genes (PDOD), for identifying drugs having opposite effects on altered states of disease genes. PDOD utilized drug-drug target interactions with effect type, an integrated directed molecular network with effect type and effect direction, and disease genes with regulated states in disease patients. With this information, we proposed a scoring function to discover drugs likely to restore altered states of disease genes using the path from a drug to a disease through the drug-drug target interactions

Motivation:** Computational drug repositioning is nowadays a widely used approach for finding new uses of existing and experimental drugs. Network-based methods, which rely on the functional relationships between drugs, genes, proteins, and diseases, have shown to be effective. ,br,**Results:** In this study, we developed network-based method, namely HDR, as an app of Cytoscape platform for drug repositioning. The task was approached in both drug- and disease-centric views. Besides, it can use both pre-installed and imported networks, thus makes the user flexible in selecting datasets of interest. In addition, predicted and existing associations between drugs and diseases as well as involved pathways/protein complexes/genes/targets can be visualized intuitively, thus supporting evidence for the predicted ones. The ability of HDR was also shown by comparing its overall prediction performance with some existing methods and by identifying drugs that can be repurposed for COVID-19 as well as ...