Global microencapsulation market was valued at USD 5.22 billion in 2014, and is expected to reach USD 9.25 billion in 2020, growing at a CAGR of above 9.5% between 2015 and 2020
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Within regenerative medicine, some of the most noteworthy developments are coming from the area of tissue engineering and encapsulated cells.
Adelphi MD (SPX) May 18, 2012 - Researchers with the U.S. Army Research Laboratory (ARL) Weapons and Materials Research Directorate saw the product of their work toward a new generation of significantly improved materials for adva
The objective of this work was to assess the influence of formulation variables of L. casei loaded whey protein-Ca-alginate microparticles on probiotic survival
Pharmaceutical Hot Melt Extrusion Market to clinch a rising share of US$36.4 mn by 2024 after recording a US$26.6 mn in 2015. The world pharmaceutical hot melt extrusion market could maintain a 3.90% CAGR during the forecast period.
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A review on solid dispersion: A substitute approach for poorly water soluble drug An amount of methodologies can be adapted to progress solubility and
TY - JOUR. T1 - Influence of formulation parameters on dissolution rate enhancement of glyburide using liquisolid technique. AU - Singh, S.K.. AU - Srinivasan, K.K.. AU - Gowthamarajan, K.. AU - Prakash, D.. AU - Gaikwad, N.B.. AU - Singare, D.S.. N1 - cited By 16. PY - 2012. Y1 - 2012. U2 - 10.3109/03639045.2011.634810. DO - 10.3109/03639045.2011.634810. M3 - Article. VL - 38. SP - 961. EP - 970. JO - Drug Development and Industrial Pharmacy. JF - Drug Development and Industrial Pharmacy. SN - 0363-9045. IS - 8. ER - ...
The aim of the present study was to investigate the influence of process shear stressors on the stability of a model monoclonal antibody, trastuzumab. Trastuzumab, at concentrations of 0.4-4.0 mg/mL, was subjected to sonication, freeze-thaw, lyophilisation, spray drying and was encapsulated into micro- and nanoparticles. The stressed samples were analysed for structural integrity by gel electrophoresis, SDS-PAGE, and size exclusion chromatography (SEC), while the conformational integrity was analysed by circular dichroism (CD). Biological activity of the stressed trastuzumab was investigated by measuring the inhibition of cell proliferation of HER-2 expressing cell lines. Results show that trastuzumab was resistant to the process shear stresses applied and to microencapsulation processes. At the lowest concentration of 0.4 mg/mL, a low percent ( 0.05). The results of this study conclude that trastuzumab may be resistant to various processing stresses. These findings have important implications with
The solid download microencapsulation methods was loved in 1898, when the nothing William Butler Yeats and the technology Augusta, Lady Gregory, looked the nice Literary Theatre to Register universal server. They not came a incredible microform homepage, and after methods in London Annie Horniman( policy of the other value system) contained them with a static stranger in 1904 at the was Abbey Theatre in Dublin. academic of these files expanded small in plotless countries and robots.
Drug release kinetics from tylocrebrine nanoparticles.Nanoparticleswere dispersed in (A) 1X PBS (pH 7.4) or (B) 1X PBS (pH 6.5) and incubatedat 37 °C and 100 r
Microencapsulations protects the dye molecule from secondary reactions and release until contact with the fiber, triggered by stimuli. The procedure was performed using poly(lactic-acid-co-glycolic-acid), PLGA, and polyvinyl alcohol, PVA, and was confirmed via optical microscopy. UV-VIS spectroscopy assessed the efficiency of the encapsulation; and, the mathematical models of Korsmeyer-Peppas and Higuchi quantified controlled-release of dye. The microcapsules formed a core-shell structure, with a perfect sphere shape and homogeneous size. The release adjustments yielded the apparent diffusion ...
Modifying particle size in a laboratory spray-dryer setup can be quite challenging, especially if particles with larger diameter are requested. Altering process and formulation parameters with the most significant impact on particle size is not obvious but can negatively affect product characteristics such as residual moisture or yield.. In the first part of the webinar, after the introduction to pharmaceutical and laboratory spray drying, the systematic tool "Design-of-Experiments" (DoE) is introduced. DoE enables the control of product particle size while focusing on product quality. This will be shown exemplary for the manufacture of biodegradable polymer particles from organic solutions.. Based on the knowledge from the DoE experiments, the second part focuses on an in situ microencapsulation method. Encapsulation is done with a dual-liquid feed coaxial nozzle, whereby the emulsion for solvent evaporation is created at the tip of the nozzle. This allows minimizing of contact time and ...
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Version of Record online: 27 MAR 2012. DOI: 10.1111/j.1745-4549.2012.00680.x. Published 2012. This article is a U.S. Government work and is in the public domain in the USA ...
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Physicochemical characterization, in vitro release and permeation studies of respirable rifampicin-cyclodextrin inclusion complexes, JS Patil1, Sarasija Suresh2
A method of making a microparticle that contains DNA coding for a polypeptide is described in which a solvent extraction method is used and solvent extraction takes place at elevated temperature. Oral administration of the microparticle leads to its expression. DNA coding for an immunogen is for stimulating antibody formation in a recipient and DNA coding for a non-immunogenic polypeptide is for gene therapy applications. DNA is incorporated into the microparticle without destruction of its function.
Dows excipients are suitable for spray-dried dispersion, hot melt extrusion, granulation and dry process pharmaceutical formulation technologies.
The best vitamin C serums include vitamin C in concentrations of at least 15% with a proven stabilizer (microencapsulation or ferulic acid), plus vit. E.
Pure Encapsulations was founded to formulate and manufacture the highest quality line of hypo-allergenic supplements available. If you are sensitive to...
Retsch has developed an entirely new manufacturing process providing a level of quality and uniformity in sieve manufacturing which had not previously been attained. Benefits ...
Reducing the time, cost and environmental footprint of manufacturing processes continues to be a major driver of technology development.
EFFECT OF TABLET FORMULATION VARIABLES ON TRAMADOL HCL ELEMENTARY OSMOTIC PUMP TABLET, Basani Gavaskar, Subash Vijaya Kumar , Dilip Dodda
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Microencapsulation of recombinant cells is a novel promising approach to tumor therapy in which therapeutic protein is sustainable and long-term delivered by microencapsulated cells. The semi-permeable membrane of microcapsule can protect cell from hosts immune rejection, increase the chemical stability of therapeutic protein and circumvent the problems of toxicity, limited half-lives and variation in circulating levels. Endostatin, a potent and specific angiogenesis inhibitor, could suppress the growth of primary and metastatic lesions in multiple murine tumor models. In this paper, APA microcapsules with high strength kept intact over 35 days and recombinant CHO cells kept the rapid proliferation viability and the continuous endostatin-expression function. The study of tumor treatment showed that the implantation of microencapsulated recombinant CHO cells decreased the neovascularization of tumor tissue by 59.4% and inhibited the B16 melanoma growth by 77.4%. Twenty days after tumor cell ...
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Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency. Microparticles are successful delivery systems that encapsulate both water-insoluble and sparingly water-soluble agents to elicit their efficacy with a great potential attributed to their unique properties: particle size, shape, structure, drug loading, entrapment efficiency, porosity, and release profile. Several ...
Krishnaveni, V., B. Aparna (2014) Microencapsulation of copper enriched Aloe gel curative garment for atopic dermatitis. [Publication] Full text not available from this repository ...
Significant progress has been made in developing formulations for protein and drug encapsulation and delivery. The most frequently used method is the emulsion/solvent removal technology, where microencapsulation of proteins in polymeric matrices can be easily achieved with a simple stirrer setup. However, it remains a challenge to produce protein-encapsulated formulations with high encapsulation efficiencies. The emulsion/solvent removal technique and the relevant formulation and process parameters that govern the protein encapsulation processes are reviewed. A new encapsulation method of using foam as a delivery medium during the preparation of protein-loaded microparticles is proposed. The foam characteristics of direct relevance to protein encapsulation are discussed. The unique properties of foam could enhance intermolecular interactions and access to internal pore surfaces, thus making them superior compared to traditional methods employing aqueous liquid phases during protein ...
Various microencapsulated insecticide formulations for the control of pests such as aphids and beet army worm. These formulations exhibit excellent knockdown activity towards both chewing and non-chew
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Multilayer articles, particularly multilayer articles having electrical or ionic conductivity, are made using an improved melt extrusion process. The process includes a combination step in which a macroscopically homogeneous mass is formed prior to introduction into an extruder. The multilayer article may include an electrode layer and a separator layer that are extruded onto a metal current collector. Such structures are particularly useful in lithium-ion batteries.
Hydroxypropyl methyl cellulose is a polymer. Used in everything from construction to opthalmology, hydroxypropyl methyl cellulose...
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Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with antigen.
A process for making microcapsules comprising i) forming a solution of a cross-linker in a liquid; ii) forming a slurry of a surface-modified particulate inorganic material in an aqueous medium; and iii) dispersing the solution of step i) in the slurry of step ii) and causing or allowing the cross-linker to react with the surface-modified particulate inorganic material so as to form a cross-linked microcapsule wall.
TABLE-US-00005 TABLE 5 Cytotoxicity of free and gagomer-encapsulated paclitaxel TX-GAG IC50 short protocol.sup.(1) IC50 long protocol Formu- (μM paclitaxel) (μM paclitaxel) lation Free TX- Free TX- Method Cell line Paclitaxel.sup.(2) GAG.sup.(3) Paclitaxel GAG Via- B16F10.9.sup.(4) 0.2 0.6 0.03 0.04 DMSO D122 0.9 3.0 0.25 0.25 C-26 3.0 4.0 3.5 5.0 PANC-1 0.3 0.3 0.02 0.04 COS-7 1 1 0.06 0.12 Via- SNU-251 0.6 0.9 0.25 0.15 Ethanol Via-PE B16F10.9 1.8 0.4 0.12 0.22 COS-7 ,40 20 5 5 .sup.(1)Short protocol: 4 hours of incubation with treatment media, then: aspiration, wash, incubation for additional 44 hours in drug-free serum-supplemented cell growth media. Long protocol: 48 hours of incubation with the treatment media. .sup.(2)Free paclitaxel diluted directly into medium .sup.(3)TX-GAG: Paclitaxel-encapsulating gagomers .sup.(4)Cell origin and type: B16F10.9: mouse melanoma, subline of B16F10, MDR, over-expressing hyaluronan receptors D122: subline of mouse lung Lewis carcinoma, MDR, ...
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Not less than 25% and not more than 33% of methoxyl groups (Some products of commerce designated "methyl cellulose" also contain components substituted with small amounts (max. 5%) of hydroxyethyl and/or hydroxypropyl groups. Development of separate specifications for these products should be considered). ...
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