In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray ...
The process for homogeneous distribution of a cellular suspension in a porous carrier material (3) for tissue engineering under using a molded body (1) with a chamber (2) having an opening for receiving the carrier material, comprises introducing the carrier material provided for colonization into the chamber. (contd)
Objective: Rizatriptan Benzoate is the 5H1 receptor agonist and used in treatment of migraine, cluster headache. The main objective is to develop ideal anti-migraine nasal mucoadhesive microparticles as local and systemic drug delivery system. Method: An attempt was made to formulate the nasal mucoadhesive microparticle of Rizatriptan Benzoate with excipients like mucoadhesive polymers i.e HPMC, ethyl cellulose etc., by using modified solvent evaporation method. And evaluated them for production yield, drug loading efficiency, surface morphology by SEM, drug content, particle size, In-vitro drug release studies. The release rates were studied using GRAPHPAD PRISM software. Result and discussion: The prepared microparticles of Rizatriptan Benzoateformulations were found to be satisfactory particle size i.e in the range of 36.96 to 53.28µm,mucoadhesion time of F5 found to be 370 min,drug content was found to be72.86 % to 81.80 % and drug release of the drug follow zero order kinetic model. Optimized
Page contains details about N-Arginine-N-octyl chitosan-coated nanostructured lipid carriers . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Nanostructured lipid carriers (NLC) composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. Before NLC can be us
Pulmonary Drug Delivery Devices Market: Overview Read the full report: http://www.reportlinker.com/p04743092-summary/view-report.html This report on pulmonary drug delivery devices
Buy Multifunctional Pharmaceutical Nanocarriers online written by Vladimir P. Torchilin,, 9780387765518 at lowest price in India. Heavy Discount. Fast Shipping. Visit online or call @91-11- 45355555
Yet despite holding so much cargo, the fully loaded nanocarriers are less than the thickness of a sheet of flimsy notebook paper.. The silica shell keeps the nanocarriers watertight. In addition, they do not interfere with healthy tissue, as Zhangs team showed by injecting healthy mice with empty nanocarriers or nanocarriers loaded with drug cargo. Five days after injection, they checked vital organs in the mice for evidence of toxicity and found none. This would indicate that the nanocarriers themselves do not trigger an adverse reaction in the body, and that the loaded nanocarriers are keeping their toxic cargo shielded from the body, said Zhang.. The UW team also designed the nanocarriers to be easily disassembled once they reached a desired location. Gentle heating from low-level infrared light was sufficient to make the nanocarriers break apart and disgorge their cargo, which is something doctors could apply to the tumor site during treatment.. As their final test of the nanocarrier ...
Development of newer drug carrier systems by the researchers has resulted in numerous breakthroughs in the development and manufacturing of ocular products. The ocular bioavailability of drugs at the posterior segment of the eye is a challenging task in the present scenario. Naturally derived macromolecular carriers are widely used to increase the efficacy of ocular drugs. They provide enhanced corneal permeability and retention effect at the surface of cornea for a prolonged period of time. In this regimen the present review focuses towards the major ocular diseases and their prevalence and development of efficient drug carrier systems utilizing various naturally derived macromolecules for improved delivery of drugs to treat ocular diseases ...
Organic light emitting devices are comprised of an organic charge carrier layer formed from a charge carrier material that is capable of forming a stable glass due to the presence of a compound having
Recent Advances reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer,
RTI uses cookies to offer you the best experience online. By continuing to use our website, you agree to the use of cookies. If you would like to know more about cookies and how to manage them please view our Privacy Policy. Learn More.. Got it! ...
The officers of RCSS/SSA had captured a lot of Yaba, heroin, and tools of drugs with drug carriers included an abbot on a car that went from Kholum to Kunhing.
One-pot approach to couple the crystallization of CaCO(3) nanoparticles and the in situ symmetry-breaking assembly of these crystallites into hollow spherical shells was developed under the templating effect of a soluble starch. Further functional study using HP-a as an anticancer drug carrier (DOX) demonstrated its advantages for localizing drug release by the pH value-sensitive structure and enhancing cytotoxicity by increasing cellular uptake, perinuclear accumulation, and nuclear entry.
Silica and Dysprosia Aerogels as Drug Carriers for Indomethacin and Paracetamol," Abstracts of Papers of the American Chemical Society, American Chemical Society (ACS), Aug 2011.. ...
The 2018 Gordon Research Conference on Drug Carriers in Medicine and Biology will be held in Waterville Valley, NH. Apply today to reserve your spot.
Page contains details about gemcitabine/doxorubicin-loaded PEG1900-S-S-PLA5800 polymersomes . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Cambridge, MA-based Alnylam Pharmaceuticals (NASDAQ:]) has been working with Tekmira Pharmaceuticals (TSE:]) of Vancouver, BC, since at least 2006 on
The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the
The physiological environment is a crucial factor in biomedical systems, which can be regulated with relative ease both in vitro and in vivo. Control of pH has emerged as a powerful strategy in cancer therapy because pH has a profound effect on the interaction of a polymeric-based drug delivery system with tumor ce
[122 Pages Report] Check for Discount on Global Solid Tumors Drugs Sales Market Report 2016 report by QYResearch Group. Notes: Sales, means the sales volume of Solid Tumors Drugs...
Drug nanocarriers are nano-objects that transport a diagnostic or therapeutic agent either on its surface, within this bulk structure or within an internal cavity.. ...
RENOLIT thermoplastic 3D films are ideal for the three-dimensional shaping and wrapping of furniture, design objects and shop fittings or wall or ceiling elements. RENOLIT 3D Thermolaminates can be shaped and cut to suit any carrier material and offer a wide range of surface and texture options. RENOLIT ALKOREN products offer a wide range of wood-effect, single-colour and patterned finishes. RENOLIT COVAREN boasts even more additional features. These films have deep embossing, a realistic feel and metallic effect. Selected décors can be produced using synchronous EIR ("Embossed in Register") technology. The synchronous pore EIR method creates a natural wood finish in virtually any shade or colour tone. There is also a full range of single-colour options available in both high-gloss and metallic finishes.. ...
Hi moms! I am looking for advice. I have a 9 week old baby who is about 10 pounds. I have the baby ktan which I bought after researching different carriers and thought it would be ideal. However, Im finding it to be super warm in there (I live in California) and also not that easy to get on and off....
To make a CDMA cell phone work with a different carrier the PRL file must be replaced. Generally there are 3 steps to this process. 1. Read or Know SPC: Thi
Description: Subject matter wherein the enzyme or microbial cell is bonded to the polymeric carrier through an intermediate compound which attaches to both the enzyme and the carrier ...
One way to find clinics for free drug screening is through UniteForSight.com. Its also possible to visit a free or low-cost health care clinic and get screened for drugs....
Does anyone know of a website that I can get the specs to see what carrier systems are matched to achieve 12 seer. For instance with a 38YRA030 would I have to up size air handler to get 12 seers?
Does anyone know of a website that I can get the specs to see what carrier systems are matched to achieve 12 seer. For instance with a 38YRA030 would I have to up size air handler to get 12 seers?
Ketofin Free is a medicine available in a number of countries worldwide. A list of US medications equivalent to Ketofin Free is available on the Drugs.com website.
Plants are natures remedies and have been used by human beings on earth since ancient times for food and medicine. Today there are global movements towards finding of herbal medicaments in plants to bring them in market via a suitable drug delivery system for mankind. The basic thought behind it is treatment of each disease is hidden in nature. However, delivery of herbal drugs also requires modification with the purpose to achieve sustain release, to increase patient compliance etc. previously herbal drugs could not attract scientists towards the modifications of novel drug delivery systems due to processing, standardizing, extracting and identification difficulties. But now days with the advancement in the technology, novel drug delivery systems (NDDS) open the door towards the development of herbal novel drug delivery system. With use of advance techniques protection from toxicity, enhancement in stability, improved bioavailability of herbal formulations, protection from physical and ...
The latest market report published by Credence Research, Inc. "Global Pulmonary Drug Delivery Devices Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025," the Pulmonary Drug Delivery Devices market was valued at USD 134.6 Bn in 2016, and is expected to reach USD 218.6 Bn by 2025, expanding at a CAGR of 5.4% from 2017 to 2025.. Browse the full report Pulmonary Drug Delivery Devices Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025 at http://www.credenceresearch.com/report/pulmonary-drug-delivery-devices-market. Market Insights. Increasing demand for noninvasive drug administration for respiratory diseases through pulmonary route is expected to boost the market of such devices. According to market experts the efficiency of pulmonary drug delivery devices is high because lungs possess ability to provide large absorptive surface area (up to 100 m2 ) but extremely thin (0.1 µm - 0.2 µm) absorptive mucosal membrane and ample ...
Market experts suggest that, There is a continuous growth in the market of drug delivery systems and will continue to grow at an impressive rate in future also. The novel drug delivery technologies enable to formulate the novel drug delivery devices by incorporating the drug molecules into new delivery systems, thus providing numerous therapeutic and commercial advantages. It was observed that NDDS market was segmented on the basis of route of administration, type of carrier and geographical region. In route of administration segment, injectable drug delivery system was observed as the largest market in 2015 followed by oral drug delivery system. Injectable drug delivery system comprises of several benefits over other dosage forms in cases such as unconsciousness, nausea, in emergency clinical episodes. The injectable administration route is the most common and efficient for delivery of active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. On the basis ...
The global novel drug delivery systems (NDDS) in cancer therapy market size was valued at USD 4.31 billion in 2016 and is projected to grow at a CAGR of 22.9% during the forecast period. Worldwide increasing incidence of cancer, availability of research funding, increase in awareness about alternative methods for treatment, and favorable reimbursement scenarios in developed nations are some of the key drivers of this market.
Novel Drug Delivery Systems Market Was Valued At USD 165.4 Bn In 2015, And Is Expected To Reach USD 202.5 Bn By 2022, Expanding At A CAGR Of 2.7% From 2016 To 2022
PCS and AFM analyses were carried out in order to characterize size and size distribution, surface properties, and shape of nanoparticles. The analyses showed that the produced nanoparticles have almost spherical shape, and they are formed with desirable surface morphology (they have very smooth surface). In addition, it was turned out that egg albumin nanoparticles had a mean size of less than 100 nm. The simple coacervation method was considered an appropriate method for the production of this type of nanoparticles. Therefore, egg albumin nanoparticles can be considered very good candidates to be used as drug and food nano-carriers ...
Transfersomes: a novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Filed
Research in novel drug delivery systems is being explored competitively in order to attain maximum therapeutic effect while minimizing the adverse effects. Despite several advancements in pharmaceutical formulations, one of the major challenges still persisting is sustained drug release. Microencapsulation enacts as an intelligent approach with a strong therapeutic impact and is in demand globally in medical technology due to its specific and attractive properties, including biocompatibility, stability, target specificity, uniform encapsulation, better compliance, and controlled and sustained release patterns that are responsible for diminishing the toxicity and dosage frequency. Microparticles are successful delivery systems that encapsulate both water-insoluble and sparingly water-soluble agents to elicit their efficacy with a great potential attributed to their unique properties: particle size, shape, structure, drug loading, entrapment efficiency, porosity, and release profile. Several ...
Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.
Niosomes are non-ionic surfactant based liposomes. Niosomes, the novel drug delivery system are self assembled vesicles primarily of synthetic surfactant incorporated with cholesterol as an excipient. They are the vesicles formed by hydrating the cholesterol and non-ionic surfactant. The main aim of niosome includes use of drug in efficient manner which includes reduced dose, reduced side effect, reduced dosage frequency, greater patient compliance and maximum concentration at the site of action so, that under exposure to the entire body. It includes higher therapeutic efficiency and reduced side effect. Niosomes are thought to be the better candidates drug delivery system due to the various factor like cost, stability, etc. various types of drug delivery is possible using niosomes like targetting drug action, ophthalmic, topical, parenteral, etc. Drug delivery potential of niosomes can be enhanced by using novel concept like proniosomes, discomes and aspasomes. Niosomes serves better aid in ...
Background: Recently, applications of albumin nanoparticles as drug delivery carriers have increased. Most toxicology studies have shown that surface chemistry and size of nanoparticles play an important role in biocompatibility and toxicity. Objective: The effect of desolvating agents with different chemical properties on the size of synthesized HSA NPs was investigated. Materials and Methods: Acetone, ethanol, methanol, and acetonitrile were used to synthesize HSA NPs with controllable size by desolvation method. Scanning electron microscopy (SEM), dynamic light scattering (DLS), and circular dichroism (CD) were employed to characterize produced particles. Finally, the toxicity of HSA NPs synthesized under different conditions was evaluated on PC-12 cells. Results: The sizes of synthesized particles differed according to the different solvents used. The sizes were 275.3 nm, 155.3 nm, 100.11 nm, and 66.2 nm for acetonitrile, ethanol, acetone, and methanol, respectively. CD showed that larger NPs had
Low molecular weight heparin-modified isoliquiritigenin-loaded solid lipid nanoparticle (LMWH-ISL-SLN) was developed for injective application. The morphological observation, particle diameter and zeta potential of LMWH-ISL-SLN were characterized using transmission electron microscopy (TEM) and a Malvern Zetasizer. Its entrapment efficiency (EE) and drug loading (DL) were determined by ultracentrifuge. The in vitro release experiments were performed by dialysis technique. The cytotoxic effects of LMWH-ISL-SLN on Hep-G2 cell lines were determined using an MTT assay. Pharmacokinetic and tissue distribution studies were conducted in kunming mice after intravenous administration of LMWH-ISL-SLN. The average drug entrapment efficiency for LMWH-ISL-SLN was (99.80 ± 3.27) %, drug loading was (18.68 ± 1.51) %, mean particle size was (217.53 ± 4.86) nm and zeta potential was (-18.24 ± 2.47) mV. The in vitro release experiments demonstrated isoliquiritigenin release from LMWH-ISL-SLN was in line with Weibull
0035] It will be understood that the haptens of the current invention may be attached to the antigenicity-conferring carrier material (accm) via a crosslinking group. The crosslinking group may be any conventional cross linking group conventionally used in this field. The crosslinking group is ideally a functionalised linking group joining the accm to the hapten. The term "crosslinking group" as used herein is any bifunctional molecule able to covalently join the hapten element to an immunogenicity conferring carrier material. A suitable crosslinking group to link with alternative carrier materials is maleimide, or a maleimide derivative, for example when BTG-maleimide is used to conjugate with the hapten via a cysteine residue. Other cross-linking groups which could also couple this group on the cysteine include haloacetyls and pyridyldisulfides. Either Lys residue, or the Glu residue (C-terminal) may alternatively be used to conjugate to a carrier material, optionally via a cross-linking ...
Results: Optimized NLCs loaded with TA were exhibited spherical shape with particle size 286.1 nm, polydispersity index 0.317, zeta potential-21.9 mV and entrapment efficiency 86.19% respectively. The result of differential scanning calorimetry (DSC) showed that drug was dispersed in NLCs in a crystalline state. In vitro release studies revealed that drug release of optimized batch was 8.34 % and 88.84% at 1h and 8h respectively. The release kinetics of the optimized NLCs best fitted the peppas-korsmeyer model. Furthermore, morphological investigations by SEM showed that optimized batch exhibit a spherical shape and a smooth surface. ...
Formation of hollow microspheres by emulsion-solventdiffusion & evaporation process.Vol. 28, Iss. 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. ...
Formation of hollow microspheres by emulsion-solventdiffusion & evaporation process.Vol. 28, Iss. 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. ...
Formation of hollow microspheres by emulsion-solventdiffusion & evaporation process.Vol. 28, Iss. 2, Gastro-Retentive Floating Drug Delivery Systems: A Critical Review. ...
Wang, Y.; Wang, H.; Chen, Y.; Liu, X.; Jin, Q.; Ji, J., 2014: Biomimetic pseudopolyrotaxane prodrug micelles with high drug content for intracellular drug delivery
West is pleased to announce that it has commenced discussions with Swissfillon AG, a provider of aseptic fill and finish services to pharmaceutical and biotechnology companies, that are intended to lead to a non-exclusive global collaboration to provide fill-finish capabilities to customers using Wests proprietary SmartDose® drug delivery platform for complex molecules.
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.