Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Soft Gelatin Capsules Market analysis is provided for global market including development trends by regions, competitive analysis of the Soft Gelatin Capsules market. These are also called as softgel. Soft gelatin capsules are manufactured as single piece capsule shell.. Soft Gelatin Capsules are a type of capsules with a solid outer shell and inner surrounding a liquid or semi-solid (inner fill) active ingredient that can be incorporated into the outer shell, the inner fill, or both.. Browse more detail information about Soft Gelatin Capsules market report at: http://www.absolutereports.com/global-soft-gelatin-capsules-market-by-manufacturers-regions-type-and-application-forecast-to-2021-10503615 Market Segment by Manufacturers, this report covers. ...

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Sublingual (abbreviated SL), from the Latin for "under the tongue", refers to the pharmacological route of administration by which substances diffuse into the blood through tissues under the tongue. Many drugs are designed for sublingual administration, including cardiovascular drugs, steroids, barbiturates, benzodiazepines, opioid analgesics, enzymes and, increasingly, vitamins and minerals. When a chemical comes in contact with the mucous membrane beneath the tongue, it is absorbed. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first-pass metabolism" in the liver before entering the general circulation. Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster,[quantify] and it ensures that the substance will risk degradation only by salivary enzymes before ...

Absorption The absolute bioavailability of a metformin hydrochloride tablets 500 mg tablet given under fasting conditions is approximately 50% to 60%. Studies using single oral doses of metformin hydrochloride tablets 500 to 1500 mg and 850 to 2550 mg, indicate that there is a lack of dose proportionality with increasing doses, which is due to decreased absorption rather than an alteration in elimination. At usual clinical doses and dosing schedules of metformin hydrochloride tablets, steady state plasma concentrations of metformin are reached within 24 to 48 hours and are generally ,1 μg/mL.. Following a single oral dose of metformin hydrochloride extended-release tablets, Cmax is achieved with a median value of 7 hours and a range of 4 to 8 hours. Peak plasma levels are approximately 20% lower compared to the same dose of metformin hydrochloride tablets, however, the extent of absorption (as measured by AUC) is comparable to metformin hydrochloride tablets. At steady state, the AUC and Cmax ...

Global Active Pharmaceutical Ingredients (API) Market, By Molecule (Small Molecule, Large Molecule), Type (Innovative Active Pharmaceutical Ingredients, Generic Innovative Active Pharmaceutical Ingredients), Type of Manufacturer (Captive API Manufacturer, Merchant API Manufacturer), Synthesis (Synthetic Active Pharmaceutical Ingredients and Biotech Active Pharmaceutical Ingredients), Chemical Synthesis (Acetaminophen, Artemisinin, Saxagliptin, Sodium Chloride, Ibuprofen, Losartan Potassium, Enoxaparin Sodium, Rufinamide, Naproxen, Tamoxifen, Others), Type of Drug (Prescription Drugs, Over-the-Counter), Usage (Clinical, Research), Potency (Low-to-Moderate Potency Active Pharmaceutical Ingredients, Potent-to-Highly Potent Active Pharmaceutical Ingredient), Therapeutic Application (Cardiology, CNS & Neurology, Oncology, Orthopedic, Endocrinology, Pulmonology, Gastroenterology, Nephrology, Ophthalmology, Other Therapeutic Application), Country (U.S., Canada, Mexico, Germany, U.K., France, Italy, Spain,

Although pharmaceutical excipients are considered pharmacologically inert, some excipients in dosage forms have shown an effect on the pharmacokinetics of certain drugs. This could be due to different mechanisms such as opening of tight junctions, inhibition of efflux transporters or interactions with the drug molecules. The presence of P-gp in the different regions of the gastrointestinal tract (GIT) is an important factor that may influence the absorption of drugs. Furthermore, the regions of the gastrointestinal tract have physiological differences that may have an impact on drug absorption, which is the reason why certain drugs have a limited absorption window after oral administration. The aim of this study was to investigate whether selected excipients, Ac-di-sol® (ADS) and Pharmacel® (PC), at different concentrations would have an effect on the transport of the model compound, Rhodamine 123 (Rho123), across excised sections of different regions from the pig gastrointestinal tract (i.e. ...

Risk Summary There are no adequate and well-controlled studies of buprenorphine sublingual tablets or buprenorphine in pregnant women. Limited published data on use of buprenorphine, the active ingredient in buprenorphine sublingual tablets, in pregnancy, have not shown an increased risk of major malformations. Reproductive and developmental studies in rats and rabbits identified adverse events at clinically relevant and higher doses. Embryofetal death was observed in both rats and rabbits administered buprenorphine during the period of organogenesis at doses approximately 6 and 0.3 times, respectively, the human sublingual dose of 16 mg/day of buprenorphine. Pre-and postnatal development studies in rats demonstrated increased neonatal deaths at 0.3 times and above and dystocia at approximately 3 times the human sublingual dose of 16 mg/day of buprenorphine. No clear teratogenic effects were seen when buprenorphine was administered during organogenesis with a range of doses equivalent to or ...

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Objective: To compare the efficacy of sublingual misoprostol and intravenous syntometrine in the active management of the third stage of labour. Study Design: It was an interventional, quasi experimental. Setting: Obstetrics and Gynecology department of Allied Hospital\Punjab Medical College, Faisalabad Duration: From 1st Nov, 2007 to 30th April 2008. Methods: 100 women were selected and randomly divided into two groups, group A (odd number) and group B (even number) by using random numbers table.600 micrograms sublingual misoprostol was given to Group A and 1 ml of intravenous syntometrine (1ml=5 IU syntocinon and 0.5 mg ergometrine) was given to Group B at the delivery of anterior shoulder of the baby. Results: As regards the efficacy of sublingual misoprostol and I.V. syntometrine, the amount of mean blood loss and use of additional uterotonics, results were not statistically significant. None of the patients required manual removal of placenta and there was no case of prolonged third stage ...

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Why there is a need for dosage forms?. Dosage forms are manufactured to ensure safe administration and ease the administration of the drug to the required site of action. Following are the reasons:. 1. Parenteral e.g. Intravenous/inhalational dosage e.g. aerosols forms to achieve fast onset of action at the site during drug delivery.. 2. Solid dosage forms like capsules, tablets to mask the undesirable taste and odor.. 3. Dosage forms like coated tablets achieve the delayed action of the drug at a certain site or protect it from the gastric juices.. 4. Topical dosage forms like creams, gels, injections to bypass first-pass metabolism (concentration of drug reduces before it reaches the systematic circulation) for faster action.. 5. Sterile dosage forms like injections, eye drops for clear, particulate-free drug administration.. 6. The suspension dosage form of such drugs that are poorly water-soluble or insoluble.. ...

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Natural polysaccharides are drawing a great deal of attention in the recent years as excipient in the pharmaceutical industry. Due to the advances in drug delivery technology, natural polysaccharides are included in controlled drug delivery to fulfill multitask functions and in some cases directly or indirectly influence the extent and /or rate of drug release. In the present study, the polysaccharides extracted from Terminalia belarica gum (TBG) were evaluated for its safety and potency towards pre formulation studies as a pharmaceutical excipient. The study was undertaken with an objective to expound the physicochemical, thermal and functional properties of polysaccharide obtained from Terminalia belarica gum (TBG). A purified component of polysaccharide was isolated from Terminalia belarica gum (TBG) by gel filtration method. Elemental analysis, Scanning electron microscopy (SEM), X-ray diffraction spectroscopy (XRD), Differential scanning microscopy (DSC) and Fourier-transformed infrared ...

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Abstract:. The objective of present study was to prepare and characterize aceclofenac sustained release tablets prepared by melt granulation technique. The granules were prepared by hydrophilic meltable binder PEG 4000. Compared to ordinary conventional technique, this method does not employ any organic solvent or water and hence reduces drying step because dried granules were obtained by cooling them. And moreover it is less time consuming process. This method can be used for granulating water sensitive material and for producing sustained release granules. Melt granulation technique fulfill today's pharmaceutical industry need because it is simple, continuous and efficient. Different formulation trials of aceclofenac tablets were prepared using PEG 4000 and among the various prepared trials, the best formulation is chosen. The best judged formulation were found to be effective in sustaining the drug release up to 10 hrs.. ...

TY - JOUR. T1 - Use of sublingual buprenorphine for pain relief in office hysteroscopy. AU - Lin, Yu Hung. AU - Hwang, Jiann Loung. AU - Huang, Lee W.. AU - Chen, Heng J.. PY - 2005/8. Y1 - 2005/8. N2 - STUDY OBJECTIVE: To assess the efficacy of sublingual buprenorphine in the relief of pain associated with office hysteroscopy. DESIGN: Prospective, randomized study (Canadian Task Force classification I). SETTING: Tertiary medical center. PATIENTS: One hundred sixty-four women referred for office hysteroscopy from September 2003 through March 2004. INTERVENTION: Before hysteroscopy, 80 women received a tablet of buprenorphine (group A), and 84 women received a placebo (group B). Their pain sensations were evaluated on a 10-cm visual analog scale, and they were asked about the adverse reactions and level of satisfaction on the following day. MEASUREMENTS AND MAIN RESULTS: The pain score in group A was 3.3 ± 1.1, which was similar to 3.2 ± 1.3 in group B. The pain scores in subgroups of women ...

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Title: 5-Fluorouracil Buccal Tablets for Locoregional Chemotherapy of Oral Squamous Cell Carcinoma: Formulation, Drug Release and Histological Effects on Reconstituted Human Oral Epithelium and Porcine Buccal Mucosa. VOLUME: 7 ISSUE: 2. Author(s):Libero Italo Giannola, Viviana De Caro, Giulia Giandalia, Maria Gabriella Siragusa, Carlo Paderni, Giuseppina Campisi and Ada Maria Florena. Affiliation:Department of Chemistry and Pharmaceutical Technologies, University of Palermo, Via Archirafi 32,90123 Palermo, Italy.. Keywords:5-Fluorouracil, Locoregional drug delivery, Porcine buccal mucosa, Reconstituted human oral epithelium, Oral squamous cell carcinoma, Buccal tablets. Abstract: 5-Fluorouracil (5-FU) is currently used for treatment of oral squamous cell carcinoma (OSCC). 5-FU is given by i.v. although the systemic administration is associated with severe toxic effects and no topical formulations of 5-FU for buccal drug delivery have been reported. In this study we would report the development ...

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A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means. That is, by an intrinsic property of the drug formulation, rather than by special mixing and handling. It employs the familiar ouzo effect displayed by anethole in many anise-flavored liquors. Microemulsions have significant potential for use in drug delivery, and SMEDDS (including so-called "U-type" microemulsions) are the best of these systems identified to date. SMEDDS are of particular value in increasing the absorption of lipophilic drugs taken by mouth. SMEDDS in research or development include formulations of the drugs anethole trithione, oridonin, curcumin, vinpocetine, tacrolimus,Mitotane, berberine hydrochloride, nobiletin, piroxicam, anti-malaria drugs beta-Artemether and halofantrine, anti-HIV drug UC 781, nimodipine, exemestane, anti-cancer drugs 9-nitrocamptothecin (9-NC) paclitaxel, and seocalcitol, alprostadil (intraurethral ...

TY - JOUR. T1 - Scalable manufacturing processes for solid lipid nanoparticles. AU - Anderluzzi, Giulia. AU - Lou Ramirez, Gustavo. AU - Su, Yang. AU - Perrie, Yvonne. PY - 2019/11/30. Y1 - 2019/11/30. N2 - Solid lipid nanoparticles offer a range of advantages as delivery systems, but they are limited by effective manufacturing processes. Within this study we outline a high-throughput and scalable manufacturing process for solid lipid nanoparticles. The solid lipid nanoparticles were formulated from a combination of Tristearin and 1,2-Distearoyl-phosphatidylethanolamine-methyl-polyethyleneglycol conjugate-2000 and manufactured using the M-110P Microfluidizer® processor (Microfluidics Inc, Westwood, Massachusetts, US). The manufacturing process was optimized in terms of the number of process cycles (1 to 5) and of process pressure change (20,000, 25,000 and 30,000 psi). The solid lipid nanoparticles were purified using tangential flow filtration, and they were characterized in terms of their ...

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The purpose of this work was to develop extended-release matrix tablets of highly water-soluble alfuzosin hydrochloride using different viscosity grades of Hydrxy propyl methyl cellulose polymers by wet granulation method. The influence of three granulating fluids viz. water, dichloromethane: ethanol and isopropyl alcohol on release rate of alfuzosin hydrochloride were studied with a view to design and development of once daily formulations of alfuzosin hydrochloride. The tablets were analysed to determine their hardness, friability, drug content and an in vitro release study was carried out. The dissolution profile indicated that the drug release was found to be influenced by the polymer and granulating fluid employed in the formulation. Based on release rate the polymers can be rated as HPMC K100M > HPMC K15M> HPMC K4M. Based on the dissolution rate the granulating fluids can be rated as water>dichloromethane: ethanol> isopropyl alcohol. The dissolution profiles followed first order kinetics and the

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In order to improve drug entrapment efficiency and loading capacity, nanostructured lipid carriers consisting of solid lipid and liquid lipid as a new type of colloidal drug delivery system were prepared. The dispersions of oridonin-loaded solid lipid nanoparticles and nanostructured lipid carriers were successfully prepared by the emulsion-evaporation and low temperature-solidification technique using monostearin as the solid lipid, caprylic/capric triglycerides as the liquid lipid and oridonin as the model drug. Their physicochemical properties of oridonin-loaded nanostructured lipid carriers and release behaviours were investigated and compared with those of solid lipid nanoparticles. As a result, the mean particle size was similar to 200 nm with narrow polydispersity index lower than 0.4 for all developed formulations. Zeta potential values were in the range -35 mV similar to -50 mV, providing good physical stability of all formulations. The differential scanning calorimetry and X-ray ...

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The meta-analysis by Triester and colleagues shows that capsule endoscopy is clearly superior to push enteroscopy and small bowel barium radiography for identifying diagnostic abnormalities in patients with OGIB. This was also true for "clinically important findings," defined as lesions definitely or probably the source of bleeding, as determined by the authors of each included study. This is not surprising, as capsule endoscopy has a farther reach and thus will detect lesions farther in the small intestine than push enteroscopy, and small bowel radiography will not detect superficial lesions of the small intestine, the most common sources of OGIB. Little difference, however, existed between capsule endoscopy and push enteroscopy in detecting tumors, arguably the most important lesion causing OGIB. A diagnostic test is only as good as the management to which it leads. In the opinion of this reviewer, a definitive therapeutic procedure (e.g., surgery) is necessary for OGIB only if a tumor is ...

The Food and Drug Administration (FDA) is announcing the availability of a guidance entitled ``Q4B Evaluation and Recommendation of Pharmacopoeial Texts for Use in the ICH Regions; Annex 5: Disintegration Test General Chapter.'' The guidance was prepared under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The guidance provides the results of the ICH Q4B evaluation of the Disintegration Test General Chapter harmonized text from each of the three pharmacopoeias (United States, European, and Japanese) represented by the Pharmacopoeial Discussion Group (PDG). The guidance conveys recognition of the three pharmacopoeial methods by the three ICH regulatory regions and provides specific information regarding the recognition. The guidance is intended to recognize the interchangeability between the local regional pharmacopoeias, thus avoiding redundant testing in favor of a common testing strategy in each ...

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The latest market report published by Credence Research, Inc. "Global Pulmonary Drug Delivery Devices Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025," the Pulmonary Drug Delivery Devices market was valued at USD 134.6 Bn in 2016, and is expected to reach USD 218.6 Bn by 2025, expanding at a CAGR of 5.4% from 2017 to 2025.. Browse the full report Pulmonary Drug Delivery Devices Market - Growth, Share, Opportunities, Competitive Analysis, and Forecast, 2017 - 2025 at http://www.credenceresearch.com/report/pulmonary-drug-delivery-devices-market. Market Insights. Increasing demand for noninvasive drug administration for respiratory diseases through pulmonary route is expected to boost the market of such devices. According to market experts the efficiency of pulmonary drug delivery devices is high because lungs possess ability to provide large absorptive surface area (up to 100 m2 ) but extremely thin (0.1 µm - 0.2 µm) absorptive mucosal membrane and ample ...

Title:Evaluation of the Influence of Splitting on Content Uniformity of Captopril Tablets. VOLUME: 9 ISSUE: 2. Author(s):Fernanda de Lima Moreira, Elisa de Oliveira Silva, Rudy Bonfilio, Olimpia Maria Martins Santos and Magali Benjamim de Araujo. Affiliation:Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 714, 37130-000, Alfenas, MG, Brazil.. Keywords:Captopril, content uniformity, pharmaceutical quality control, tablet splitting, tablet-splitter, High performance liquid chromatography. Abstract:Tablet splitting has been a practice widely used. The aim of this work is to investigate the influence of splitting on content uniformity of 25 mg captopril tablets, a common dosage form. Split tablets were obtained by using the hands, a knife or a tablet-splitter. Captopril reference product and two different brands codified as X and Y were used in this study. The method used for quantification was that described in The United States Pharmacopoeia, 30th ed. The results showed that the ...

A high potency yeast-free multiple vitamin and mineral formula. One hard gelatin capsule supplies: Beta-Carotene (pro-vitamin A) 10000 IU Vitamin D (from natural form vitamin D-3) 400 IU Vitamin C 150 mg Natural Vitamin E (succinate) 100 IU Vitamin B-1 (thiamine) 25 mg Vitamin B-2 (riboflavin) 25 mg Vitamin B-6 (pyridoxine) 25 mg Vitamin B-12 (cobalamin concentrate) 100 mcg Niacinamide 100 mg Pantothenic Acid 50 mg Biotin 300 mcg Folic Acid 400 mcg PABA (para-aminobenzoic acid) 25 mg Choline Bitartrate 25 mg Inositol 25 mg Calcium (from calcium citrate & calcium carbonate) 25 mg Magnesium (from magnesium aspartate & magnesium oxide) 7.2 mg Potassium (from potassium aspartate & potassium citrate) 5 mg Zinc (from zinc picolinate) 15 mg Copper (from copper gluconate) 2 mg Manganese (from manganese gluconate) 5 mg Iodine (from potassium iodide) 150 mcg Selenium (from selenomethionine & selenate-50/50 mixture) 200 mcg Chromium (GTF) 200 mcg Molybdenum (natural molybdate) 150 mcg ...

A validated RP-HPLC method for simultaneous determination of propranolol and of propranolol hydrochloride and valsartan in pharmaceutical dosage form. Development and Validation of HPLC Methods for the Determination of Propranolol Hydrochloride and Hydrochlorothiazide Related Substances in Combination USP Propranolol Hydrochloride Assay by HPLC-UV (TN-1090) and throughput benefits to be applied to methods requiring the use of a C8 (USP L7) column. Propranolol. Hydrochloride is a non-selective beta blocker, that is, it blocks Hcl in tablets. Keywords: Etizolam, Propranolol HCl, RP-HPLC method validation. Results: The developed method was linear for Propranolol Hydrochloride from 10 Ultra Performance Liquid Chromatography (UPLC) is comes from HPLC. DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CLONAZEPAM AND PROPRANOLOL HYDROCHLORIDE 29 Apr 2012 0 2 for propranolol hydrochloride and flunarizine dihydrochloride. [11-15] and spectrophotometric methods [16, 17] and ...

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A dietary supplement to support immune system functions.Immuno-DMG is an advanced nutritional supplement that combines 2 patented and highly researched products: Gluconic N,N-Dimethylglycine (DMG), ImmunEnhancer AG (Larch Tree Extract) with a highly purified Maitake mushroom extract called the D-Fraction, and Beta-1,3 Glucan in an enteric coated, vegetarian tablet. These nutrients work synergistically to balance and support immune system functions. SUGGESTED USAGE: Take 1 tablet, 3 times daily. INGREDIENTS:SERVING SIZE:1 Enteric Coated Vegetable Tablet SERVINGS PER CONTAINER: 90 AMOUNT PER SERVING: Dimethylglycine HCl 300 mg Maitake PD-Fraction(Grifola frondosa) Extract 17 mg (yielding D-Fraction 5 mg) Larix occidentalis (Larch tree) Extract 227 mg (yielding Arabinogalactan polysaccharides 222.5 mg) Beta 1, 3 Glucan (from baker s yeast cell walls) 100 mg Microcrystalline cellulose, stearic acid, vegetable stearate, croscarmellose sodium, silicon dioxide, hydroxypropyl methylcellulose, talc, titanium

The present study describes new, simple, rapid and novel spectrophotometric methods for simultaneous estimation of Tramadol Hydrochloride and Ketorolac Tromethamine in bulk and capsule formulation. The combination was analysed by simultaneous equation method (Method A), Absorbance correction method (Method B) and First order derivative spectroscopic method (Method C). Method A involved measurement of absorbance at two wavelengths, 271 nm and 246 nm, ?max of Tramadol hydrochloride and Ketorolac tromethamine respectively. For method B, wavelengths 331 nm (for determination of Ketorolac tromethamine) and 271 nm were used. For method C, wavelengths 339.2 nm (Zero crossing of Tramadol hydrochloride) and 229.4 nm (Zero crossing of Ketorolac tromethamine) were used for determination of Ketorolac tromethamine and Tramadol hydrochloride respectively. Beer's law was obeyed in concentration range of 5-50 µg/ ml and 2-20 µg/ ml for Tramadol hydrochloride and Ketorolac tromethamine respectively by all the methods.

0038] When the dosage form reaches the proximal part of the gastrointestinal tract (GIT), i.e., the duodenum or the small intestine, the enteric polymer, or acid insoluble and base soluble polymer, in the hydrophilic matrix polymers are dissolved or dispersed in the intestinal content. This exposes drug particles within the polymer matrix to intestinal fluids, and offers a large surface area for drug dissolution and drug release from the polymer matrix. At the same time, high molecular weight non-enteric polymers remaining in the polymer matrix dissolve or swell in the viscous intestinal fluids, forming a viscous gel around the drug particles. Release of the water soluble drug in the small intestine is retarded by this viscous gel, resulting in a gradual release of drug in the intestine. Thus, the release profile of the water soluble drug is controlled by the combination of enteric and non-enteric polymers, where enteric polymers act to retard drug release in the stomach, while non-enteric ...

Various techniques for physical characterization of active pharmaceutical ingredients, including X-ray powder diffraction, birefringence observation, Raman spectroscopy, and high-performance liquid chromatography, can be conducted using 96-well plates. to indicate the heat. The model medicines used were indomethacin (melting heat, 160C), mannitol (166C), carbamazepine (174C, … Emissivity of the samples is required to calculate absolute temps. That of the pharmaceutical powders was about 0.86 in most cases, and this value can be used at least for the testing purposes. Figure?5 shows the surface temps of indomethacin and carbamazepine determined using the infrared camera. In the case of indomethacin, before melting, the surface temperature of the samples improved at a heating rate identical to that of the sample plate, even though heat itself was lower than that of the surrounding plate. This was followed by a drastic increase in the sample temperature, caused by an increase in the thermal ...

Abstract:. Aim and Objective: Solubility is the important physicochemical factors which affect the absorption of drug and therapeutic effectiveness. The poor solubility of drug substance in water and low absorption in aqueous GIT fluid leads to insufficient bioavailability. The purpose of present research work is to increase the aqueous solubility and dissolution rate of poorly water soluble drug. Materials and Method: Solubility of diflunisal enhanced by solid dispersion (kneading method) method using beta cyclodextrin as a carrier (also act as taste masking agent). Fast dissolving tablet of diflunisal was prepared by direct compression method using crospovidone as a superdisintigrant from optimized solid dispersion complexes. Prepared tablets were evaluated for various parameters: weight variation, hardness, friability, modified dispersion time, disintegration test, drug content and drug release. Results and conclusion: From the results obtained it has been concluded that prepared tablets from ...