DOLICHOL MONOPHOSPHATE MANNOSE | C106H175O9P | CID 6434507 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Molecular Plant-Microbe Interactions 24:1522-1529...Patrycja Zembek,1,2 Urszula Perlińska-Lenart,1 Kurt Brunner,2 Barbara Reithner,2 Grażyna Palamarczyk,1 Robert L. Mach,2 and Joanna S. Kruszewska1...
A series of sulfonated biphenylphosphanes were readily prepared from commercially available, inexpensive, and air-stable organic compounds. Of these, the trisulfonated trisbiphenylphosphane can be considered as a true water-soluble analogue of PPh3 as the cone angle and basicity of both phosphanes are very close and result in a similar coordination mode on palladium and rhodium complexes. The catalytic performance of the trisulfonated trisbiphenylphosphane was evaluated in the aqueous hydroformylation of 1-decene and the Tsuji-Trost reaction. ...
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In the absence of detergent, the transfer of mannose from GDP-mannose to rat liver microsomal vesicles was highly stimulated by exogenous retinyl phosphate in incubations containing bovine serum albumin, as measured in a filter binding assay. Under these conditions 65% of mannose 6-phosphatase activity was latent. The transfer process was linear with time up to 5min and with protein concentration up to 1.5mg/0.2ml. It was also temperature-dependent. The microsomal uptake of mannose was highly dependent on retinyl phosphate and was saturable against increasing amounts of retinyl phosphate, a concentration of 15μm giving half-maximal transfer. The uptake system was also saturated by increasing concentrations of GDP-mannose, with an apparent Km of 18μm. Neither exogenous dolichyl phosphate nor non-phosphorylated retinoids were active in this process in the absence of detergent. Phosphatidylethanolamine and synthetic dipalmitoylglycerophosphocholine were also without activity. Several ...
Babczinski, P., Haselbeck, A. and Tanner, W. (1980). „Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur. J. Biochem. 105: 509-515. PMID 6989607 ...
DUBLIN, Dec 1, 2016 /PRNewswire/ -- Global Market Report On Di-N-Octyl Phenyl Phosphate 2016 - Manufacture Methods & Technology Development - Research and...
Involved in ascorbic acid biosynthesis and in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
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We reported that the C‐terminal 24 amino acids of DPM1 are necessary for association with DPM2 and that Phe21 and Tyr23 in DPM2 are important for association with DPM1 (Maeda et al., 1998). Because the present results suggest that DPM2 associates with DPM1 indirectly through DPM3, these previous observations should be interpreted as indicating that the C‐terminal 24 amino acids of DPM1 are necessary for association with DPM3 and that DPM2 associates with DPM3 using its first transmembrane domain, which includes Phe21 and Tyr23.. DPM1 stabilized with DPM3 in the absence of DPM2 had DPM synthase activity, indicating that DPM2 is not essential for the enzymatic reaction. However, the specific enzymatic activity was 10 times higher when DPM2 was present (Figure 7). Therefore, DPM2 plays a role in the enzymatic reaction. Since DPM2 is very hydrophobic, it seems possible that DPM2 facilitates usage of dolichol‐phosphate. Alternatively, association of DPM2 might cause a steric change in DPM3 that ...
K03857 PIGA; phosphatidylinositol N-acetylglucosaminyltransferase subunit A [EC:2.4.1.198] K03859 PIGC; phosphatidylinositol N-acetylglucosaminyltransferase subunit C K03858 PIGH; phosphatidylinositol N-acetylglucosaminyltransferase subunit H K03858 PIGH; phosphatidylinositol N-acetylglucosaminyltransferase subunit H K03861 PIGP; phosphatidylinositol N-acetylglucosaminyltransferase subunit P K03860 PIGQ; phosphatidylinositol N-acetylglucosaminyltransferase subunit Q K11001 PIGY; phosphatidylinositol N-acetylglucosaminyltransferase subunit Y K11001 PIGY; phosphatidylinositol N-acetylglucosaminyltransferase subunit Y K09658 DPM2; dolichol phosphate-mannose biosynthesis regulatory protein K09658 DPM2; dolichol phosphate-mannose biosynthesis regulatory protein K03434 PIGL; N-acetylglucosaminylphosphatidylinositol deacetylase [EC:3.5.1.89] K05283 PIGW; glucosaminylphosphatidylinositol acyltransferase [EC:2.3.-.-] K01127 GPLD1; glycosylphosphatidylinositol phospholipase D [EC:3.1.4.50] K05284 PIGM; ...
THE UNAMBIGUOUS CHARACTERIZATION OF DOLICHOL PHOSPHATE MANNOSE AS A PRODUCT OF MANNOSYL TRANSFERASE IN PIG LIVER ENDOPLASMIC RETICULUM = LA CARACTERISATION NON EQUIVOQUE DU DOLICHOL PHOSPHATE MANNOSE COMME PRODUIT DE LA MANNOSYL TRANSFERASE DANS LE RETICULUM ENDOPLASMIQUE DU FOIE DE PORCEVANS PJ; HEMMING FW.1973; F.E.B.S. LETTERS; NETHERL.; DA. 1973; VOL. 31; NO 3; PP. 335-338; BIBL. 26 REF.Serial Issue ...
PHENYL PHOSPHATE DISODIUM SALT (CAS 3279-54-7) Market Research Report 2018 aims at providing comprehensive data on phenyl phosphate disodium salt market
2) dolichyl β-D-mannosyl phosphate + L-seryl-[protein] = dolichyl phosphate + 3-O-(α-D-mannosyl)-L-seryl-[protein]. For diagram of reaction click here.. Other name(s): dolichol phosphomannose-protein mannosyltransferase; protein O-D-mannosyltransferase; dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase; dolichyl-phosphate-mannose-protein mannosyltransferase. Systematic name: dolichyl-D-mannosyl-phosphate:protein O-D-mannosyltransferase. Comments: The enzyme transfers mannosyl residues to the hydroxy group of serine or threonine residues, producing cell-wall mannoproteins. It acts only on long-chain α-dihydropolyprenyl derivatives, larger than C35.. Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 74315-99-4. References:. 1. Babczinski, P., Haselbeck, A. and Tanner, W. Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme. Eur. J. Biochem. ...
The effects of addition of 1 microM-dexamethasone on the rate of transfer of mannose from GDP-mannose into mannolipid have been studied in HeLa cell cultures. Concurrent with an increase in incorporation of mannose into glycoproteins, the incorporation of mannose from GDP-mannose in vitro into mannolipid and dolichol-linked oligosaccharides was increased after dexamethasone treatment. Stimulation of mannolipid synthesis showed a correlation with the 11 beta, 17 alpha, 21-trihydroxy structure of C21 steroids. Dexamethasone treatment also resulted in an increased incorporation of acetate into dolichol and dolichyl phosphate. The results suggest that the effect of dexamethasone on the cell-surface glycoprotein accumulation is related to increased sugar-linked dolichol synthesis. ...
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
p,The crystal structure of the title water-soluble analogue of vitamin E, trolox amide, C(14)H(19)NO(3), solved and refined against synchrotron diffraction data, contains two mol-ecules in the asymmetric unit. In both molecules, the heterocyclic ring is in a half-chair conformation. The crystal packing features a herring-bone pattern generated by N-H⋯O hydrogen bonds between the hy-droxy and amide groups. O-H⋯O hydrogen bonds also occur.,/p,. ...
N-linked glycosylation of proteins in eukaryotic cells follows a highly conserved pathway. The tetradecasaccharide substrate (Glc3Man9GlcNAc2) is first assembled at the membrane of the endoplasmic reticulum (ER) as a dolichylpyrophosphate (Dol-PP)-linked intermediate, and then transferred to nascent …
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Godelaine, D. ; Beaufay, Henri. The Dolichol Pathway of Protein Glycosylation in Rat-liver - Evidence That Gtp Promotes Transformation of Endogenous Dolichyl Phosphate Into Dolichylpyrophosphoryl-n-acetylglucosamine in Stripped Rough Microsomes. In: European Journal of Biochemistry, Vol. 131, no. 3, p. 667-670 (1983 ...
TY - JOUR. T1 - Suppression of Rft1 expression does not impair the transbilayer movement of Man5GlcNAc2-P-P-dolichol in sealed microsomes from yeast. AU - Rush, Jeffrey S.. AU - Gao, Ningguo. AU - Lehrman, Mark A.. AU - Matveev, Sergey. AU - Waechter, Charles J.. PY - 2009/7/24. Y1 - 2009/7/24. N2 - To further evaluate the role of Rft1 in the transbilayer movement of Man5GlcNAc2-P-P-dolichol (M5-DLO), a series of experiments was conducted with intact cells and sealed microsomal vesicles. First, an unexpectedly large accumulation (37-fold) of M5-DLO was observed in Rft1-depleted cells (YG1137) relative to Glc3Man9GlcNAc2-P-P-Dol in wild type (SS328) cells when glycolipid levels were compared by fluorophore-assisted carbohydrate electrophoresis analysis. When sealed microsomes from wild type cells and cells depleted of Rft1 were incubated with GDP-[3H]mannose or UDP-[3H]GlcNAc in the presence of unlabeled GDP-Man, no difference was observed in the rate of synthesis of [3H]Man9GlcNAc2-P-P-dolichol ...
Fingerprint Dive into the research topics of Retinyl Palmitate, Retinyl Phosphate, and Dolichyl Phosphate of Postnuclear Membrane Fraction from Hepatoma, Host Liver, and Regenerating Liver: Marginal Vitamin A Status of Hepatoma Tissue. Together they form a unique fingerprint. ...
TY - JOUR. T1 - Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins. AU - Lalloo, Anita. AU - Chao, Piyun. AU - Hu, Peidi. AU - Stein, Stanley. AU - Sinko, Patrick J.. PY - 2006/5/30. Y1 - 2006/5/30. N2 - Inadequate drug delivery, due to problems associated with achieving constant therapeutic blood levels, has hampered the use of anticancer agents of the camptothecin (CPT) class. The objective of the current studies was to develop a depot delivery system for the water-soluble analog of CPT, topotecan (TPT). In this study, a 2-phase drug depot consisting of TPT-loaded liposomes entrapped in a poly(ethylene glycol) hydrogel was designed. Physically entrapped unaltered TPT displayed a rapid release rate from the hydrogel. Controlled release was demonstrated in vitro and in vivo from the 2-phase system with constant blood levels being achieved for several days in rats. Cytotoxicity and ...
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Accepted name: dolichyl-P-Man:Man8GlcNAc2-PP-dolichol α-1,2-mannosyltransferase. Reaction: dolichyl β-D-mannosyl phosphate + D-Man-α-(1→2)-D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→6)]-D-Man-α-(1→6)]-D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol = D-Man-α-(1→2)-D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→2)-D-Man-α-(1→6)]-D-Man-α-(1→6)]-D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate. For diagram of reaction click here.. Other name(s): ALG9; ALG9 α1,2 mannosyltransferase; dolichylphosphomannose-dependent ALG9 mannosyltransferase; ALG9 mannosyltransferase; Dol-P-Man:Man8GlcNAc2-PP-Dol α-1,2-mannosyltransferase. Systematic name: dolichyl β-D-mannosyl phosphate:D-Man-α-(1→2)-D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→2)-D-Man-α-(1→3)-[D-Man-α-(1→6)]-D-Man-α-(1→6)]-D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol ...
Previous in vivo studies showed the combination pentoxifylline (PTX) and a-tocopherol was highly efficient in reducing late radiation-induced skin damage. The present work aimed at investigating the molecular and cellular mechanisms involved in the effects of this combination. Primary cultures of confluent dermal fibroblasts were ?-irradiated in the presence of PTX and trolox (Tx), the water-soluble analogue of a-tocopherol. Drugs were added either before or after radiation exposure and were maintained over time. Their antioxidant capacity and their effect on radiation-induced ROS production was assessed together with cell viability and clonogenicity. DNA damage formation was assessed by the alkaline comet assay and by the micronucleus (MN) test. Cell cycle distribution was also determined. The combination of PTX/ Tx was shown to reduce both immediate and late ROS formation observed in cells after irradiation. Surprisingly, decrease in DNA strand breaks measured by the comet assay was observed ...
The biosynthesis of eukaryotic lipid-linked oligosaccharides (LLOs) that act as donor substrates in eukaryotic protein N-glycosylation starts on the cytoplasmic side of the endoplasmic reticulum and includes
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dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06262 ...
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In the present study, we report our recently developed new approach to inducing antigen-specific immune response. We use two nucleophilic substitution click chemistry processes to successfully couple protein antigens or peptides to mouse spleen cells or T cells by a heterobifunctional crosslinker, succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) or sulfo-SMCC. SMCC and its water-soluble analog sulfo-SMCC contain N-hydroxysuccinimide (NHS) ester and maleimide groups, which allow stable covalent conjugation of amine- and sulfhydryl-containing molecules in trans. Protein coupling to cells relies on the free sulfhydryls (thiols) on cell surfaces and the free amines on protein antigens. Although the amount of protein coupled to cells is limited due to the limited number of cell surface thiols, the injection of spleen cells coupled with antigenic proteins, such as keyhole limpet hemocyanin (KLH) or ovalbumin (OVA), induces a potent antigen-specific immune response in vivo, which is even
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alpha 1-4-mannosyltransferase: from Mycobacterium smegmatis; involved in methylmannose polysaccharide elongation; GDP-mannose is donor
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This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010 ...
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N-linked glycosylation of proteins in eukaryotic cells follows a highly conserved pathway. The tetradecasaccharide substrate (Glc3Man9GlcNAc2) is first assembled at the membrane of the endoplasmic reticulum (ER) as a dolichylpyrophosphate (Dol-PP)-linked intermediate, and then transferred to nascent polypeptide chains in the lumen of the ER. The assembly of the oligosaccharide starts on the cytoplasmic side of the ER membrane with the synthesis of a Man5GlcNAc2-PP-Dol intermediate. This lipid-linked intermediate is then translocated across the membrane so that the oligosaccharides face the lumen of the ER, where the biosynthesis of Glc3Man9GlcNAc2-PP-Dol continues to completion. The fully assembled oligosaccharide is transferred to selected asparagine residues of target proteins. The transmembrane movement of lipid-linked Man5GlcNAc2 oligosaccharide is of fundamental importance in this biosynthetic pathway, and similar processes involving phospholipids and glycolipids are essential in all types ...
GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase, GDP mannose polyisoprenylphosphate mannosyltransferase, GDP, GD2 beta1,3-galactosyltransferase, Online Electronic Medical Dictionary Terminology, Articles, Glossary
Determine Phosphatase enzyme Procedure in Milk Disodium phenyl phosphate Phosphates 2,6 dibromo quinine chlorimide faint blue colour appeare test for pasteurization of milk
Email: [email protected] Web: http://www.an-gene.com/ Name CAS ID ETHYL PICOLINATE 2524-52-9 AG-E-76780 1-BROMO-2,5-DIMETHOXYBENZENE 25245-34-5 AG-E-76783 4-(4-MORPHOLINO)ANILINE 2524-67-6 AG-E-76788 BENZENE, ETHENYL-, DIMER 25247-68-1 AG-E-76794 POLYVINYLPYRROLIDONE CROSS-LINKED 25249-54-1 AG-E-76807 2-BROMO-5-IODOBENZOIC ACID 25252-00-0 AG-E-76822 DIPROPYLENE GLYCOL 25265-71-8 AG-E-76901 METHYL ALPHA ?BROMO-2-CHLORO-PHENYL ACETATE 25270-30-4 AG-E-76948 1-METHYL-PIPERIDINE-2-CARBOXYLIC ACID X HCL 25271-35-6 AG-E-76951 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE 252742-72-6 AG-E-76966 DIBUTYL PHENYL PHOSPHATE 2528-36-1 AG-E-77008 8-BROMO-5-NITRO-ISOQUINOLINE…
Order GDP-mannose-dependent alpha- 1-6 -phosphatidylinositol dimannoside mannosyltransferase-E coli 01022698370 at Gentaur GDP-mannose-dependent alpha (1-6) phosphatidylinositol dimannoside mannosyltransferase
GDP-Man: Man1GlcNAc2-PP-dolichol α-1,3-mannosyltransferase / GDP-Man: Man2GlcNAc2-PP-dolichol α-1,6-mannosyltransferase (Alg2;YGL065c ...
Read Characterization and Localization of a Long‐Chain Isoprenyltransferase Activity in Porcine Brain: Proposed Role in the Biosynthesis of Dolichyl Phosphate, Journal of Neurochemistry on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
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GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis-undecaprenol GDP + D-Man-alpha-(1->3)-D-Glc-beta-(1->4)-D-Glc-alpha-1-diphospho-ditrans,octacis- ...