With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
The yeast Saccharomyces cerevisiae strain W303 synthesizes in the early logarithmic phase of growth dolichols of 14-18 isoprene residues. The analysis of the polyisoprenoids present in the stationary phase revealed an additional family which proved to be also dolichols but of 19-24 isoprene residues, constituting 39% of the total dolichols. The transfer of early logarithmic phase cells to a starvation medium lacking glucose or nitrogen resulted in the synthesis of the longer chain dolichols. The additional family of dolichols represented 13.8% and 10.3% of total dolichols in the glucose and nitrogen deficient media, respectively. The level of dolichols in yeast cells increased with the age of the cultures. Since both families of dolichols are present in stationary phase cells we postulate that the longer chain dolichols may be responsible for the physico-chemical changes in cellular membranes allowing yeast cells to adapt to nutrient deficient conditions to maintain long-term viability ...
The effects of addition of 1 microM-dexamethasone on the rate of transfer of mannose from GDP-mannose into mannolipid have been studied in HeLa cell cultures. Concurrent with an increase in incorporation of mannose into glycoproteins, the incorporation of mannose from GDP-mannose in vitro into mannolipid and dolichol-linked oligosaccharides was increased after dexamethasone treatment. Stimulation of mannolipid synthesis showed a correlation with the 11 beta, 17 alpha, 21-trihydroxy structure of C21 steroids. Dexamethasone treatment also resulted in an increased incorporation of acetate into dolichol and dolichyl phosphate. The results suggest that the effect of dexamethasone on the cell-surface glycoprotein accumulation is related to increased sugar-linked dolichol synthesis. ...
Read Hypoglycosylation due to dolichol metabolism defects, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Godelaine, D. ; Beaufay, Henri. The Dolichol Pathway of Protein Glycosylation in Rat-liver - Evidence That Gtp Promotes Transformation of Endogenous Dolichyl Phosphate Into Dolichylpyrophosphoryl-n-acetylglucosamine in Stripped Rough Microsomes. In: European Journal of Biochemistry, Vol. 131, no. 3, p. 667-670 (1983 ...
The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.
1. The transfer of mannose from GDP-(U-14-C)mannose into endogenous acceptors of bovine adrenal medullla and rat parotid was studied. The rapidly labelled product, a glycolipid, was partially purified and characterized. 2. It was stable to mild alkaline hydrolysis but yielded (14-C)mannose on mild acid hydrolysis. It co-chromatographed with mannosyl phosphoryl dolichol in four t.l.c. systems and on DEAE-cellulose acetate. Addition of dolichol phosphate or a dolichol phosphate-enriched fraction prepared from pig liver stimulated mannolipid synthesis. 3. The formation of mammolipid appeared reversible, since addition of GDP to a system synthesizing the mannolipid caused a rapid loss of label from the mannolipid. UDP-N-acetylglucosamine did not inhibit mannolipid synthesis except at high concentrations (2 mM), even though in the absence of GDP-mannose, N-acetylglucosamine was incorporated into a lipid having the properties of a glycosylated polyprenyl phosphate. 4. Mannose from GDP-mannose was also ...
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T lmintav telez ses m dszerek (t lmintav telez ses PCM, szigma-delta modul torok, zajform l s, jitter-anal zis, teljes tm nyviszonyok s korl tok). Az irregul ris mintav telez s klasszikus ter letei (elveszett-adat probl m ja, radarjelek anal zise) s j alkalmaz s-orient lt motiv ci i a bio-rendszerek, szenzor-h l zatok s kis teljes tm ny anal g-digit lis talak t k oldal r l. Line ris algebrai alapok (vektor- s jelterek, norma, bels -szorzat). Oper torelm leti alapok (adjung lt, nadjung lt s projektor oper torok). Fourier-transzform ci s s jelelm leti alapok ttekint se. Bernstein- s Wirtinger-egyenl tlens g. S vhat rolt jelek rekonstrukci ja irregul risan vett mint ib l oper tor-iter ci val, konvergencia-krit riumok. Id k dol s c lja, id k dol rendszerek s ramk r k. Teljes tm ny- s VLSI-szempontok neuron-szer id k dol k eset n. Id dek dol s oper tor-iter ci val, konvergencia-krit riumok. Az oper tor-iter ci m trix formalizmusa, hat kony algoritmusok kifejleszt se Toeplitz-m trixok s a L ...
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Complete information for DHDDS gene (Protein Coding), Dehydrodolichyl Diphosphate Synthase Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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As always, if a situation occurs that makes you feel unsafe, give yourself permission to leave and seek assistance. In the unlikely event that you are confronted by someone who is threatening shout and make a scene to draw attention to yourself as you seek the safety of a campus building or local business. If someone threatens you with physical harm for your property, you may be better off giving them your property than getting hurt. Your property can always be replaced. Report all crimes to Campus Public Safety or 911. Additional crime prevention information can be found at www.seattleu.edu/safety/ ...
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09:21, 24 October 2013 (diff , hist) Glycosylation ‎ (Sugar residues are most commonly added the -NH2 of a Asn on the non-cystolic surface. They are transferred by a lipid (Dolichol) to the target and then trimmed and packaged.) ...
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Popular Name(s): Haji Husayn Cik Dol, Tuan Guru Haji Cik Dol Origin: Location(s): Biographical Details: b. 1904, Pondok Gajah Mati, Pendang, Kedah, though his father was from Patani and had come to Kedah to teach and opened a pondok in that town. His mother, Hajah Kalthom, also came from Patani, though the exact origin is…
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DOLICHOL MONOPHOSPHATE MANNOSE | C106H175O9P | CID 6434507 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
J Lipid Res. 2007 Jul;48(7):1457-62. Epub 2007 Apr 19. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, Non-P.H.S.
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A variety of sulfo-protected monosaccharide donors and acceptors were investigated in glycosylation reactions. Trifluoroethylsulfonate (SO3TFE) group was compatible with a wide range of activation conditions commonly used with fluoride, imidate, and sulfide donors. In addition, the influence of a SO3TFE group, at the critical 2-position in glycosyl donor, on the stereoselectivity of the glycosylation reaction was studied ...
There are over 40 known congenital disorders of glycosylation (CDGs), and a reformulation of their nomenclature has been proposed by Dr. Jaak Jaeken, who described the first CDG (Jaeken et al, 2009, Biochim Biophys Acta 1792:825-6). A new CDG has now been identified in several families (Cantagrel et al, 2010, Cell 142:203-17). Patients present notably with neurological disease, coagulation defects and skin findings (ichtiosis, dermatitis). By linkage and sequencing of candidate genes, mutations were found in SRD5A3 , encoding an enzyme which converts polyprenol to dolichol, a membrane anchor for oligosaccharides, thus shedding new light on the earliest steps of protein N-glycosylation.. Philippe Campeau, MD. ...
The enzyme, characterized from the methanogenic archaeon Methanococcus voltae, participates in the N-glycosylation of proteins. Dolichol used by archaea is different from
Though Dr. Wertzberger spoke at Shaare Tefilah the week of Purim, his remarks serve as a reminder that people with drinking problems don t confine their drinking to Purim or to Simchas Torah. Of course, those are popular dates on which to focus our attention on this issue.. But this is also a good time to speak about Pesach. This is a tricky time for a young man with a secret drinking problem. We are obligated to drink rov cos. How convenient. We could imbibe to our hearts content and if we get sloppy who will say anything?. Dr. Wertzberger was also referring to the habitual weekend drinker, the man who consumes two shots at the shul kiddush club, two or three more shots at the regular shul kiddush, two shots at home making kiddush for his family and finally another one or two with the meal. These ten shots consumed every Shabbos between shul and home dont go unnoticed by this mans children. Children learn by example.. My Name Is, and Im an ...
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New cross-linked polymeric foam compositions, and methods for making the same, are provided. The new compositions utilize novel cross-linked polyolefin copolymers and show improvements in strength, toughness, flexibility, heat resistance and heat-sealing temperature ranges as compared to conventional low density polyethylene compositions. The new compositions also show processing improvements over linear low density polyethylene. The novel polyolefins, which are essentially linear, comprise ethylene polymerized with at least one alpha-unsaturated C3 to C20 olefinic comonomer, and optionally at least one C3 to C20 polyene, and exhibit, in an uncross-linked sense, a resin density in the range of about 0.86 g/cm3 to about 0.96 g/cm3, a melt index in the range of about 0.5 dg/min to about 100 dg/min, a molecular weight distribution in the range of from about 1.5 to about 3.5, and a composition distribution breadth index greater than about 45 percent.
Originally designed to block just the reductase step to cholesterol synthesis, the final truth about statins is that they block the entire mevalonate pathway, including the synthesis of CoQ10 and dolichols and several other biochemicals.
B14. Advances in plant biochemistry Lectures L27.1 Polyisoprenoids secondary metabolites or physiologically important superlipids? Liliana Surmacz, Ewa Swiezewska Institute of Biochemistry and Biophysics,
dolichyl beta-D-glucosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol = alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + dolichyl phosphate [RN:R06262 ...
On December 11, 2020, the Department of Labor released a final regulation revising DOLs rules for the voting (or not voting) of proxies by ERISA plan fiduciaries.
On February 25, 2016, the U.S. Department of Labor (DOL) issued its long-awaited proposed rule to implement Executive Order 13706, which requires…
This dataset shows the Battery Electric Vehicles (BEVs) and Plug-in Hybrid Electric Vehicles (PHEVs) that are currently registered through Washington State Department of Licensing (DOL ...
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EQ: What are the two major subdivisions of cells? What are the defining structures of cells? (Lab book page 28 RIBBON OF LIFE)* You will utilize the program FOSS: The Ribbon of Life (User Name=Palmyra PW= Our mascot) to answer prompts in the lab book. ...
DOL 9 Exam will be FRIDAY 1/27. Best way to prepare is to look over the Know, Understand, and Do part of the DOL 9 wiki. In addition, review lessons and Quizlet on that page. Lab book pages 61-65 and review sheets will also be good to look over. This exam will be a Gmail exam only since the lab report will be the substitute for the written portion of the exam ...
Po kalivosti sadika naredi dva klična lista, ki zrasteta 25-35 mm v dolžino in imata mrežaste listne žile.[14] Nato ta dva lista na robu naredita lesno krono. Stalni listi so nasprotni (pod pravim kotom glede na klične liste), amfistomatični (z režami na obeh straneh lista), mrežastimi listnimi žilami. Kmalu ko se pojavita lista, apical meristem umre in meristemsko dejavnost prenese na obod krošnje. Lista zato nenehno rasteta iz bazalnih meristem in dosežeta dolžino do 4 m. Konice listov so razcepljene na več ločenih trakov v obliki odsekov, ki jih izkrivljajo leseni deli, ki obdajajo apikalno zarezo, pa tudi veter in naključne zunanje poškodbe. [15] Največje so 1,5 m visoko nad tlemi, vendar obseg listov v stiku s peskom lahko presega 8 m. [16] Velbičevka ima podolgovat, plitev koreninski sistem, sestavljen iz zožene cevaste korenine z enim ali več necevastimi oddvojki, nekaterimi izrazito stranskimi koreninami in mrežo občutljivih gobastih korenin [17] in leseno, ...
Nukleosóm je pri evkariotih enota v organizaciji kromatina, ki obsega približno 146 baznih parov DNK, ki je 1,67-krat tesno ovita okrog histonskega oktamera, torej osmih histonskih molekul (po dve kopiji histonov H2A, H2B, H3, H4).[1]. Nukleosome povezuje povezovalna DNK dolžine do 80 baznih parov vezana na zunanji histon H1. Nukleosomi omogočajo strnjenost celotne dednine v jedru, ki meri približno 10 μm. Več nukleosomov se povezuje v kromosom. Nukleosomi so nosilci epigenetskih informacij v obliki kovalentnih modifikacij pripadajočih jedrnih histonov. Niso statične, temveč dinamične strukture. Vezavo transkripcijskih faktorjev na posamezna mesta na DNK lahko facilitirajo ali zavirajo.. ...
Kryeministri britanik Tony Blair tha se e kupton që lufta në Irak ka ndikuar në ndarjen e vendit. Duke folur në konferencën vjetore të partisë së tij laburiste Blair pranoi se pohimet sipas të cilave Sadam Hyseini dhe Iraku zotonin armë kimike dhe biologjike dolën se janë të pavërteta. Të...
Looking for online definition of dolichyl phosphate glucosyltransferase in the Medical Dictionary? dolichyl phosphate glucosyltransferase explanation free. What is dolichyl phosphate glucosyltransferase? Meaning of dolichyl phosphate glucosyltransferase medical term. What does dolichyl phosphate glucosyltransferase mean?
We reported that the C‐terminal 24 amino acids of DPM1 are necessary for association with DPM2 and that Phe21 and Tyr23 in DPM2 are important for association with DPM1 (Maeda et al., 1998). Because the present results suggest that DPM2 associates with DPM1 indirectly through DPM3, these previous observations should be interpreted as indicating that the C‐terminal 24 amino acids of DPM1 are necessary for association with DPM3 and that DPM2 associates with DPM3 using its first transmembrane domain, which includes Phe21 and Tyr23.. DPM1 stabilized with DPM3 in the absence of DPM2 had DPM synthase activity, indicating that DPM2 is not essential for the enzymatic reaction. However, the specific enzymatic activity was 10 times higher when DPM2 was present (Figure 7). Therefore, DPM2 plays a role in the enzymatic reaction. Since DPM2 is very hydrophobic, it seems possible that DPM2 facilitates usage of dolichol‐phosphate. Alternatively, association of DPM2 might cause a steric change in DPM3 that ...
Effects of treatment with serum-free medium and 25-hydroxycholesterol (25-OH) on the cell cycle of simian virus 40-transformed 3T3 fibroblasts, designated SV-3T3 cells, were studied and compared with simultaneous effects on the activity of 3-hydroxy-3-methylglutaryl (HMG) CoA reductase and incorporation of [3H]mevalonic acid into cholesterol, Coenzyme Q, and dolichol. The data confirm our previous finding (O. Larsson and A. Zetterberg, Cancer Res., 46: 1233-1239, 1986) that 25-OH inhibits the cell cycle traverse of SV-3T3 cells specifically in early G1. In contrast, treatment with serum-free medium had no effect on cell cycle progression. The effect of 25-OH on the cell cycle traverse was correlated to a substantial decrease in the activity of HMG CoA reductase, whereas there was no change in the rate of [3H]mevalonic acid incorporated into cholesterol, Coenzyme Q, and dolichol. When the cells were exposed to serum-free medium, there was no depression of activity of HMG CoA reductase, and the ...
Genetic causes for autosomal recessive forms of dilated cardiomyopathy (DCM) are only rarely identified, although they are thought to contribute considerably to sudden cardiac death and heart failure, especially in young children. the N-glycosylation pathway, the causative gene could be identified as dolichol kinase (with a predominantly nonsyndromic presentation of DCM. In addition, we show that the main presenting symptom of DOLK-CDG is usually caused by deficient O-mannosylation of sarcolemmal alpha-dystroglycan. Results Clinical presentation of dilated cardiomyopathy Dilated cardiomyopathy was diagnosed in several children (observe pedigree; Physique 1), without significant muscular weakness or creatine kinase (CK) elevation. Central nervous system involvement, such as cerebellar ataxia, epilepsy or intellectual disability was not present in the patients, except for transient muscular hypotonia and moderate developmental delay with a minor increase of CK in family IV. Decreased coagulation ...
You might not think to look to a urine test to diagnose an eye disease. But a new Duke University study says it can link what is in a patients urine to gene mutations that cause retinitis pigmentosa, or RP, an inherited, degenerative disease that results in severe vision impairment and often blindness. The findings appear online in the Journal of Lipid Research.. My collaborators, Dr. Rong Wen and Dr. Byron Lam at the Bascom Palmer Eye Institute in Florida first sought my expertise in mass spectrometry to analyze cells cultured from a family in which three out of the four siblings suffer from RP, said Ziqiang Guan, an associate research professor of biochemistry in the Duke University Medical School and a contributing author of the study. Guans collaborators had previously sequenced the genome of this family and found that the children with RP carry two copies of a mutation at the dehydrodolichol diphosphate synthase (DHDDS) gene, which makes the enzyme that synthesizes organic compounds ...
McDougall concluded: All statins inhibit HMG-CoA reductase at the rate-limiting step of the mevalonate pathway, an intricate biochemical pathway required for the production of cholesterol, isoprenoids, dolichol, ubiquinone, and isopentenyladine. Laboratory studies have investigated how disrupting the melavonate pathway may lead to carcinogenesis. Our finding of an increased risk only among current long-term statin users suggests that the chronic dysregulation of the mevalonate pathway and/or long-termlowering of serum cholesterol may contribute to breast carcinogenesis. ...
Magnus Bentinger is responsible for synthesis of new compounds with the ability to stimulate the endogenous antioxidant defence, various naturally occurring polyisoprenoids that are chemically modified. These synthetic products are purified, characterized and tested in both in vitro and in vivo systems. He is responsible for studies on drug development with focus on the ability to stimulate endogenous antioxidant defence including mechanistic studies and for the analyses of CoQ10 in different organs of diabetic and control mice.. Forskargrupp Tillväxt och metabolism. Selected publications. Coenzyme Q--biosynthesis and functions. ...
Prosecutor Captain John Atwill said: Put simply, he had very clearly over-consumed a very large amount of the free alcohol and his behaviour descended at the lunch reception to the point where a number of people had to intervene. ...
allergen Dol M I: from hornet (Dolichovvespula maculata); it is a phospholipase A1 with weak lipase activity; contains 300 amino acid residues; amino acid sequence given in first source
The U.S. Department of Labor (DOL) released proposed regulations that would implement President Joe Bidens Executive Order (EO) that would establish…
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New guidance from the Department of Labor helps plan sponsors to offer ESG or environmental social and governance investing strategies to plan participants.
Bulletin on the Department of Labors anoouncement for a Notice of Proposed Rulemaking with regard to the FMLAs definition of spouse.
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