An electrochemical test method is proposed for determination of the susceptibility of materials to internal hydrogen embrittlement IHE. The method is based on the assumption that the relative susceptibility of a material depends both on the specific aqueous environment to which the material is exposed and to the dissimilar materials to which it is coupled. Potentiosatic techniques are employed to impress potential on sustained loaded notched round- bar specimens. The result is a plot of impressed potential versus time-to- failure superpositioning of the resultant curves provides a basis for rating the relative susceptibility of various materials to IHE.
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The technical difficulties associated with measuring coupled and uncoupled 1H spin signals in the human neck are substantial. Artifacts arising from motion and other instabilities, particularly in the presence of high lipid concentrations, can corrupt metabolite intensity measurements. Shimming can be difficult because of local susceptibility differences, and localization may be compromised when using a PRESS-based sequence, which allows for the prescription of only rectangular volumes of interest that, most likely, will not exactly encompass the lesion. Despite these and other difficulties, it seems that several trends have emerged that may provide impetus for further investigations.. The results show that there was a significant increase in Cho:Cr ratios in lymph node metastases of squamous cell carcinoma as compared with normal muscle tissue. The increased ratios resulted more from a decline of the Cr signal than from an elevation of Cho. Of note is that the mean Cho:Cr value of 2.9 was 71% ...
Lets discuss antibiotic resistance, micro biomes, and strain susceptibilities from our injections and what this means for human evolution.
Provides a detailed analysis of the study of genes and environments and their interaction, and how the use of population sciences facilitates translation
Using an accelerated longitudinal design, the development of externalizing problems from age 2 to 5 years was investigated in relation to
Here's a piece of biology news that escaped us, last month, but was brought to our attention by a story in the BBC today: Biologist have found the
TY - CHAP. T1 - Relative susceptibilities of potato genotypes with a single resistant gene for Meloidogyne Chitwoodi. AU - Teklu, M.G.. AU - Been, T.H.. AU - Schomaker, C.H.. PY - 2012. Y1 - 2012. N2 - Four potato genotypes with a single resistant gene against M. chitwoodi were examined for their degree of relative susceptibility compared to the susceptible cv. Désirée. The potato genotypes were grown in 10-liter pots in artificial soil at a range of initial nematode densities (Pi) from 0 (control), 0.125, 0.25, 0.5, 1, 2, 4, 8, 16, 32, 64 to 128 juveniles (gram of dry soil)-1. The pot experiment was carried out in a climate controlled glasshouse. The final population density (Pf) and various plant characteristics such as plant height, fresh and under water weight of tubers, fresh root weight, shoot and root dry weight were measured and related to initial nematode density to model yield. Additionally, the root-knot index (RKI) of the tubers was assessed. Plant height was found to increase with ...
Waggie, K S.; Hansen, C T.; Ganaway, J R.; and Spencer, T S., A study of mouse strain susceptibility to bacillus piliformis (tyzzers disease): the association of b-cell function and resistance. (1981). Subject Strain Bibliography 1981. 2192 ...
Recent dramatic advances in the understanding of inherited susceptibility to several common adult-onset cancers have made possible the identification of individuals who may be at significantly increased risk of developing malignant disease. These advances may translate into some of the first opportunities for cancer prevention.
Abstract Marine invasions have been identified in virtually all regions of the world, yet relatively few introductions have been detected in the Tropics. This has been attributed at least in part to an increase in intrinsic native community resistance at lower latitudes resulting from strongly interacting food webs in high(er) diversity systems. However, recent evidence from surveys in Australia and elsewhere indicate that tropical systems are also susceptible to invasions, though detection ability may be constrained by taxonomic limitations. Preliminary analyses of data from surveys designed to detect introduced species do not support a pattern of decreased invasion success in higher diversity systems but do indicate a strong latitudinal gradient at the mesoscale of Australia. This cannot be attributed to disparities in search effort (controlled for by consistency in survey effort) or taxonomic knowledge. The original hypothesis of a decreased relative susceptibility of tropical versus ...
Susceptibility weighted imaging (SWI), originally called BOLD venographic imaging, is an MRI sequence that is exquisitely sensitive to venous blood, hemorrhage and iron storage. SWI uses a fully flow compensated, long echo, gradient recalled echo (GRE) pulse sequence to acquire images. This method exploits the susceptibility differences between tissues and uses the phase image to detect these differences. The magnitude and phase data are combined to produce an enhanced contrast magnitude image. The imaging of venous blood with SWI is a blood-oxygen-level dependent (BOLD) technique which is why it was (and is sometimes still) referred to as BOLD venography. Due to its sensitivity to venous blood SWI is commonly used in traumatic brain injuries (TBI) and for high resolution brain venographies but has many other clinical applications. SWI is offered as a clinical package by Philips and Siemens but can be run on any manufacturers machine at field strengths of 1.0 T, 1.5 T, 3.0 T and higher. SWI ...
Although the recent evidence for individual differences in plasticity is quite compelling, the authors are very tentative and cautious in their papers, which I suppose is necessary when youre proposing something new. You dont want to scare anyone off. So they are keen to point out that the evidence is not quite solid as yet, and there is more work to be done.. This line of work is only beginning, and there are many unknowns. Much the same as in priming research, the evidence of the effect is running a little ahead of the understanding of the mechanisms involved, and researchers are unclear on whether differential susceptibility stems mostly from nature or nurture, or on the breadth of the phenomena that it applies to. Having said that, the idea that that the people most susceptible to negative symptoms and experiences might be the people most susceptible to positive symptoms and experiences, is quite a cheerful thought.. References:. (1) Belsky, J., & Pluess, M. (2009). Beyond diathesis ...
Cancer incidence varies markedly by ethnicity and geographic location. Ethnic variation in cancer occurrence has traditionally been ascribed to differences in social, cultural, economic, and physical environments. However, this interpretation of the epidemiologic evidence may need to be revised as a result of new biological evidence and theories of carcinogenesis. Carcinogenesis is now recognized
A proton located at the edge of the FOV in the readout direction precesses at the Nyquist frequency ????NQ above or below the transmitter frequency ????TR . Changing the FOV of the image changes the spatial resolution (millimeters per pixel) but not the frequency resolution (hertz per pixel). 2)). 4) where Δ????RO is the total range of frequencies in the image. 6). 7). 7 For a given range (bandwidth) of frequencies that are measured in the signal, the desired FOV is determined by the readout gradient amplitude. This inhomogeneity is transient during the measurement. The contributions of the imaging gradients may be eliminated as a source of dephasing through proper design of the measurement process, as described in Chapter 4. 2) where T2M is the dephasing time due to the main field inhomogeneity and T2MS is the dephasing time due to the magnetic susceptibility differences. 3) where MXY max is the transverse magnetization MXY immediately following the excitation pulse. For most tissues or ...
The discovery of inherited gene mutations that increase the risk of certain cancers could greatly expand the use of predictive genetic testing in healthy individuals. In families with hereditary forms of cancer, the use of genetic tests to determine whether family members have inherited suseptibility mutations (ISMs} may improve out come. 1
Genetic testing and counseling is available for patients at risk for breast, ovarian and colon cancer. BRCA1 and BRCA2 testing is available.
A young patient with severe disease whose plaque control is good would be regarded as having a high susceptibility whilst an elderly patient with poor plaque control and little evidence of disease would be regarded as having a low susceptibility. Susceptibility is thus a very individual concept relating to each patient. It must be appreciated that a patients innate susceptibility cannot be changed as this is partly genetically determined. Recognition of this has led to the realization that risk recognition and control forms an essential part of periodontal management, particularly in patients with higher susceptibility.. ...
Effects of Efflux Transporter Genes on Susceptibility of Escherichia coli to Tigecycline (GAR-936): The activity of tigecycline, 9-(t-butylglycylamido)-minocycl
Sato, K; Bloom, E T.; and Makinodan, T, Effect of age and radiation on susceptibility to plasmacytoma induction. Abstr. (1982). Subject Strain Bibliography 1982. 2046 ...
Sjogren syndrome likely results from a combination of genetic and environmental factors (multifactorial). Several different genes appear to affect the risk of developing the condition, however, specific genes have yet to be confirmed. Simply having one of these genes does not cause a person to develop the disease; some sort of trigger is also needed. That trigger may be a viral or bacterial infection. The genetic variations that increase susceptibility may reduce the bodys ability to turn off the immune response when it is no longer needed. The possibility that the endocrine and nervous systems may play a role in the disease is also under investigation.. ...
Another accepted theory is that BPD may be a result of biological and genetic factors.. According to research, there is evidence to suggest a genetic component. Parents with BPD have an increased likelihood of having children who are prone to BPD and other psychiatric disorders. Genetic factors may cause a slight susceptibility to a person developing BPD. This susceptibility may only result in a disorder when nurtured in a triggering environment i.e. that of abuse or neglect.. Some medical professionals also believe that physical problems in the brain may be a contributing factor or cause of BPD. It has been suggested that BPD can be attributed to brain damage caused to a baby in the womb or during or after birth. There is also some evidence of organic lesions in the brains of people with BPD. Brain imaging has reportedly seen abnormalities in the brains of BPD sufferers.. Other than physical damage to the brain, it has been theorised that there may be a chemical dysfunction in the brains of BPD ...
rs8034191 increases susceptibility to Lung cancer 1.27 times for heterozygotes (CT) and 1.80 times for homozygotes (CC) [PMID 18385738] rs8034191 increases susceptibility to Lung cancer 1.28 times for heterozygotes (CT) and 1.81 times for homozygotes (CC) [PMID 18385676 ...
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Researchers funded by the NIH Genotype-Tissue Expression project have created a data resource to help establish how differences in individual genomic make-up can affect gene activity and contribute to disease. It will enable scientists to examine the genomics of different human tissues and cells. Investigators reported findings from a pilot study, providing insights into how genomic variants control when and how much genes are turned on and off in tissues, and predispose people to disease.
When you focus on the now, you lower barriers that inhibit your susceptibility to spontaneously arising thoughts. You become aware of your own presence
Symptoms of Malignant hyperthermia susceptibility type 2 including 7 medical symptoms and signs of Malignant hyperthermia susceptibility type 2, alternative diagnoses, misdiagnosis, and correct diagnosis for Malignant hyperthermia susceptibility type 2 signs or Malignant hyperthermia susceptibility type 2 symptoms.
Soil-agar blocks infested with chlamydospores of Phytophthora parasitica were an effective inoculum source for screening citrus rootstocks for relative susceptibility to foot rot. Mean percentage of stem girdling, lesion area, and relative lesion area were similar on stems inoculated with soil-agar blocks containing seven to 100 chlamydospores or inoculated with 1,000 zoospores. Foot rot severity ratings were significantly higher when inoculum consisted of 0.5-cm-diameter mycelial agar disks compared with chlamydospores or zoospores. Commercial rootstocks known to be moderately resistant to or with field tolerance to foot rot were rated as susceptible when mycelial agar disks were used as an inoculum source. The use of quantifiable inoculum sources such as chlamydospores or zoospores may allow evaluation of rootstocks with intermediate levels of resistance to foot rot.. ...
Relief is when you and the right researcher find each other Finding the right clinical trial for Malignant hyperthermia susceptibility type 3 can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
Relief is when you and the right researcher find each other Finding the right clinical trial for Malignant hyperthermia susceptibility type 1 can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity. ...
A stress corrosion test procedure that employs electrochemical potentiostatic polarization techniques has been presented. A potentiostatic stress corrosion life curve PSCLC was developed for various materials. The PSCLC can be used to show the effect of galvanic coupling on stress corrosion cracking. The best material for resistance to stress corrosion cracking can be determined by superimposing the PSCLC for each specific material and then partitioning the specific potential range. Also, the orders of magnitude scatter band that are observed in time-to-failure data are explained by this test procedure. The time to failure has been shown to be dependent on the electrochemical potential that exists between the environment and the material. This potential dependency on SCC has not been accounted for in stress corrosion testing. Author
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
R. C. Levitt, N. Nouri, A. E. Jedlicka, V. A. McKusick, A. R. Marks, J. G. Shutack, J. E. Fletcher, H. Rosenberg, D. A. Meyers ...
Are the causes of schizophrenia organic (biochemical/physiological) or functional (resulting from experience)? At the moment, perhaps because of the wide array of newly developed brain-scanning techniques, the organic explanations are far more prominent. However, the best answer may lie in a synthesis of the two points of view. The main theory in practice today is the diathesis-stress model, which merges two different areas of research.. First, some definitions. A diathesis is a predisposition to a particular disease. Stress can be defined as any number of psychological and social factors. So, the diathesis-stress model holds that schizophrenia is the consequence of a stress-activated diathesis or predisposition.. Proposed biological diathesis for schizophrenia includes problems with brain chemistry and/or development. Researchers have found malformed parts of the brain in people with schizophrenia. These biological abnormalities can lead to problems with thinking, speech, behavior, and staying ...
Immune cell activation and differentiation occurs concurrently with metabolic reprogramming. This ensures that activated cells generate the energy and substrates necessary to perform their specified function. Likewise, the metabolic programs among different cells of the immune system vary. By targeting different metabolic pathways, these differences allow for selective regulation of immune responses. Further, the relative susceptibility of cells to a metabolic inhibitor is dictated by their metabolic demands; cellular selectivity is based on demand. Therefore, where differences exist in metabolic pathways between healthy and pathogenic cells, there is opportunity for selective regulation with agents lacking intrinsic specificity. There are now a host of studies demonstrating how inhibitors of metabolism (e.g., glycolysis, glutamine metabolism, and fatty acid oxidation) can regulate immune responses and treat immune-mediated pathogenesis. In this brief review we detail how inhibitors of ...
A high percentage of African American women with breast cancer who were evaluated at a university cancer-risk clinic were found to carry inherited genetic mutations that increase their risk for breast cancer.
Eggerthella lenta ATCC ® 43055™ Designation: MSMC 77-67 TypeStrain=False Application: Quality control strain Susceptibility testing
Eggerthella lenta ATCC ® 43055™ Designation: MSMC 77-67 TypeStrain=False Application: Quality control strain Susceptibility testing
This study has demonstrated that deficiency of BMPR-II increases susceptibility to PAH induced by serotonin in mice. Although the pulmonary vascular phenotype of BMPR2+/− and wild-type littermates was similar under normoxic or chronic hypoxic conditions, infusion of serotonin increased RVSP, RVH, and pulmonary vascular remodeling in BMPR2+/− mice compared with controls. These data provide the first evidence for cross-talk between the BMP and serotonin pathways, both key systems implicated in the pathogenesis of pulmonary hypertension. Serotonin infusion was associated with a reduction in lung Smad1/5 activation in hypoxic mice. Serotonin inhibited BMP signaling in PASMCs, as evidenced by inhibition of Smad1/5 phosphorylation and inhibition of Id3 transcription. Furthermore, PASMCs isolated from BMPR2+/− mice exhibited a heightened DNA synthesis to serotonin and increased activation of ERK1/2 via O·−2. Moreover, we found that pulmonary, but not systemic, arteries from BMPR2+/− mice ...
Complete information for MHS4 gene (Genetic Locus), Malignant Hyperthermia Susceptibility 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Dealing with adolescence and teenage has always remained a problem for parents because of the vulnerability to habit formation, the curiosity to experiment and susceptibility to get easily influenced by peers.
To start with, these PKC inhibitors confirmed time-dependent alterations in their potencies after activation of PKC. The time-dependent alterations for equally BIS I and BIS IV have been very best equipped by single exponential features, which implies a solitary phase transition to a new equilibrium. Curiously, even though BIS I and BIS IV are structurally quite equivalent to each and every other, the alterations in efficiency following activation of PKC ended up opposite BIS I showed an improve in efficiency although BIS IV exhibited a lessen in potency. These outcomes recommend that BIS compounds have unique affinities for both quiescent or activated PKC. Secondly, BIS I preferentially inhibited preactivated PKC. This is evidenced by greater susceptibility to inhibition of preactivated PKC and a considerably faster time training course to attain the plateau inhibition in preactivated PKC. In contrast, BIS IV did not demonstrate preference for activated PKC. The key structural variation between ...
As the organism ages, it exhibits a degree of correlated, recognizable, and predictable changes to its physiology over time. These changes can occur synchronously across multiple tissues and organs. The phenotypic changes of aging occur in a type of concert, rather than in isolation, suggesting the residual participation of the endocrine system in the onset of age-related phenotypes. The demise of the cell thus most often occurs within the context of the simultaneous demise of the whole organism.. Organelles and cellular subtypes also exhibit a differential susceptibility to stress during aging. This preference can result in the consistent advent and spreading of disease across particular subsets and even subcompartments of the cells. Thus age-onset diseases often begin in one distinct tissue before signs of dysfunction spread infectiously along reproducible networks, affecting the physiology of distal tissues in distinct but foreseable patterns. We are trying to understand how the small and ...
ICD-9 code V84.02 for Genetic susceptibility to malignant neoplasm of ovary is a medical classification as listed by WHO under the range - GENETICS (V
A study of smoking susceptibility among adolescents who had never smoked has found that Hispanics are more susceptible to smoking.
Does Noonan Syndrome Increase Malignant Hyperthermia Susceptibility : Topic Does Noonan Syndrome Increase Malignant Hyperthermia Susceptibility Robert Shaw (medical student), Ari Weintraub, MD, Ronald Litman, DO
Fitzpatrick Skin Type I | Characteristics, Best Skin Care Practices & Suitable Treatments for type 1 skins available at Body Renewal Clinics in South Africa
Fitzpatrick Skin Type IV | Characteristics, Best Skin Care Practices & Suitable Treatments for type 4 skins available at Body Renewal Clinics in South Africa
One of the more interesting aspects of C. neoformans interactions with the host is the large discrepancy in the incidence of infections in male and female patients, with males having a higher incidence of C. neoformans infection and disease than females. This gender-related difference has been observed in dozens of studies and suggests underlying differences in the interactions of the immune response to C. neoformans infection and differential expression of microbial factors between males and females. We have found differences in the immune response of ex vivo male or female macrophages to C. neoformans, PLoS One, 2013. Currently, we are characterizing gender-specific and microbial factors in clinical isolates to determine which factors are involved in the gender susceptibility difference to C. neoformans.. 2. Determine how C. neoformans modulates cell signaling in macrophages Another key aspect of the C. neoformans host-pathogen interaction is with host macrophages. I am collaborating with Dr. ...
We found that this phenomenon was associated with the different susceptibility of human and mouse NK cells to autologous tumour cell-induced NK cell abnormalities (NKCA). The latter includes CD16 down-regulation and NK cell depletion. Induction of NKCA by leukaemia and solid tumour cells was influenced neither by IL2 treatment nor by HLA class I antigen expression, but was abrogated by a 10 day culture. Following a 10 day of PBMCs culture, NK cells became resistant to leukaemia and solid tumor cell induced NKCA but maintained their cytotoxic activity. Actinomycin D restored the susceptibility of long term NK (LTNK) cells to NKCA suggesting that the generation of resistance to NKCA required RNA transcription. TAPI-0, a functional analogue of the tissue inhibitor of metalloproteinases (TIMP) 3 inhibited cancer cell induced NKCA underlying a role for a restricted number of metalloproteinases in the generation of this phenomenon. Finally, we found an association of TIMP3 gene and protein ...
Diets deficient in amino acids -- chemicals that make up proteins -- can significantly increase susceptibility to epileptic seizures in rats, according to a study by researchers at the University of California, Davis. The findings may lead to a betterunderstanding of some of the mechanisms involved with epilepsy in humans.
New Approaches for Chagas Disease Chemotherapy. By Guadalupe García Liñares. The latest advances concerning drug design and chemotherapy development to combat the Chagas disease are discussed. This chapter is based on the metabolic differences between the pathogenic parasite and mammal hosts that led to the progress in the search for novel metabolic pathways in parasites that may be essential for parasites survival but with no counterpart in the host. There is a considerable amount of work in the search of more promising molecular targets for drug design. However, the chemotherapy for this disease remains unsolved. It is based on old and fairly not specific drugs associated with long-term treatments, severe side effects, drug resistance, and different strains susceptibility. Herein, a thorough analysis of selected molecular targets is described in terms of their potential usefulness for drug design. Therefore, rational approaches to the chemotherapeutic control of American trypanosomiasis ...
The overall aim of this review was to assemble the evidence that will help unravel the genetic components underlying differences in response to TB. Research in livestock host variability in response to BTB could deliver genetic markers such as SNPs associated with resistance. Implementation could be by the use of genetic markers associated with TB resistance/susceptibility in existing breeding programmes or even the identification of genetically susceptible sires to avoid their use in high BTB prevalence regions. The latter approach could help to achieve the goal set by Cox et al. (2005) who argued that even modest reduction in the reproduction number of M. bovis in cattle could bring the current epidemic under control.. It is possible that M. bovis and cattle may have reached an evolutionary stalemate, as has been proposed for humans (Muse Davis & Ramakrishnan 2009). While this proposed tolerance of host for pathogen and pathogen for host may well be an example of coevolution to maximize the ...
Vlutations in either type 1 ryanodine receptor (RyR1) or the dihydropyridine receptor subunit Cav1.1 cause malignant hyperthermia susceptibility (MHS) in humans...
A hereditary disease can be transmitted through genetic material, like a father to one of his sons. For some hereditary diseases, as a type of breast cancer, doctors know exactly which gene causes the problem, and therefore, what is the probability of being passed along.. The genes are not known exactly related to bipolar disorder, which makes it difficult to explain the exact mechanisms of how the condition is genetically transmitted. The main theory is that many different genes, each from a small part, lead to bipolar disorder.. The primary hypothesis is that several different genes relate in a limited way to bipolar disorder. As said by Aimee Daramus PsyD, a clinical psychologist licensed and author of Bipolar Understanding Disorder: The Essential Family Guide[5]. Bipolar disorder is a type of diathesis-stress process, which means that an individual may inherit a greater probability of disruption, but that others may inherit a greater probability of disruption rather than physical harm or ...
If mice surviving a lethal dose of mouse typhoid bacilli are inbred consecutively for a number of generations, the resulting offspring become progressively more resistant to mouse typhoid infection and to mercury bichloride intoxication than similar control mice not so selected.. ...
rs1667394 increases susceptibility to Blond rather than brown hair 4.94 times for carriers of the A allele [PMID 17952075] rs1667394 increases susceptibility to Blue rather than brown eyes 29.43 times for carriers of the A allele [PMID 17952075] rs1667394 increases susceptibility to Blue rather than green eyes 6.74 times for carriers of the A allele [PMID 17952075] For green versus blue eye color rs12913832 in OCA2/HERC2 has a score of 51.5 and an estimated allelic OR of 8.43 . The SNP rs1667394 in this same region has an estimated OR of (4.85-10.06). 10.1371/journal.pgen.1000993 ...
In this study, we aimed to characterise rapid progressors to type 1 diabetes among children recruited from the general population, on the basis of HLA-conferred disease susceptibility. We monitored 74
Parkinson disease susceptibility to MT-TT related (NGS Sequencing: MT-TT) Test Cost INR 30000.00 Surat Pune Jaipur Lucknow Kanpur Nagpur Visakhapatnam Indore Thane Bhopal Patna Vadodara Ghaziabad Ludhiana Coimbatore Madurai Meerut Ranchi Allahabad Trivandrum Pondicherry Mysore Aligarh best offer discount price
In a randomized controlled trial we tested the role of genetic differences in explaining variability in intervention effects on child externalizing behavior. One hundred fifty-seven families with 1- to 3-year-old children screened for their relatively high levels of externalizing behavior participat …
Signs of Glioma Susceptibility 5 including medical signs and symptoms of Glioma Susceptibility 5, symptoms, misdiagnosis, tests, common medical issues, duration, and the correct diagnosis for Glioma Susceptibility 5 signs or Glioma Susceptibility 5 symptoms.
Multiple Sclerosis (MS) is a chronic inflammatory disease of the brain and spinal cord that leads to various degrees of disability. The cause of MS is not yet known, however, there is strong evidence indicating that both an inherited susceptibility and environmental factors play an important role in its aetiology. ...
Author Summary The environment humans inhabit has changed many times in the last 100,000 years. Migration and dynamic local environments can lead to genetic adaptations favoring beneficial traits. Many genes responsible for these adaptations can alter disease susceptibility. Genes can also affect disease susceptibility by varying randomly across different populations. We have studied genetic variants that are known to modify disease susceptibility in the context of worldwide migration. We found that variants associated with 11 diseases have been affected to an extent that is not explained by random variation. We also found that the genetic risk of type 2 diabetes has steadily decreased along the worldwide human migration trajectory from Africa to America.
TY - JOUR. T1 - Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. AU - liu, Xia. PY - 2016/1/26. Y1 - 2016/1/26. M3 - Article. JO - 2016. JF - 2016. ER - ...
In this study, women who reported moderate susceptibility to breast cancer were most likely to adhere to mammography screening guidelines. High perceived susceptibility adversely influenced adherence in the total sample, but its influence was stronger among women ages ≥50 years. In contrast, the adverse effect of low perceived susceptibility was found only in women ages 40 to 49 years. These effects of perceived susceptibility were found in relation to time to first screening as well as to nonadherence.. Miller (27) proposed that health beliefs, such as perceived disease susceptibility, have less influence on a health behavior once that behavior is habitually practiced. One reason for the stronger effect of low perceived susceptibility on women ages 40 to 49 years than on women ages ≥50 years may be that mammography screening was a relatively new behavior and may not yet have become a habit for many of the younger women. In addition, during the data collection period of this study, ...
The reversible polymerization of proteins is a process necessary for life. In neurodegeneration, the abnormal and seemingly irreversible polymerization of several different abundant proteins in the brain pathologically defines disease into predictable stages. Linkage analyses and genome-wide associations prove that these proteins that form fibrils, oligomers, and other conformations are not mere bystanders in disease susceptibility but can drive neurodegeneration. Yet, inclusion abundance often poorly predicts clinical phenotypes, and mixed pathologies common in patients that involve several different proteins challenge therapeutics that directly target protein aggregation. Recent studies have nominated critical modulators of disease susceptibility and progression that include inflammation, microbiome, and the cell-to-cell propagation of abnormal proteins. Biomarkers that unravel disease heterogeneity to identify patients that might benefit most from targeting these critical modifiers promise to ...
Researchers in Australias Centre for Innate Immunity and Infectious Diseases at the Monash Institute of Medical Research have identified a new protein, ...
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and
New University of British Columbia research found that receiving antibiotic treatments early in life can increase susceptibility to specific diseases later on. Most bacteria living in the gut play a positive role in promoting a healthy immune system, but antibiotic treatments often do not discriminate between good and bad bacteria. The study published today in…
Thus, this genome-wide scan implicates, in addition to the MHC, regions outside the MHC in AS susceptibility, especially on chromosomes 6q and 11q.
The Research platform iRiSC - Inflammatory Response and Infection Susceptibility Centre is a collaborative network of researchers at Örebro University and
Traditional and New Diagnostic Identification Methods and Susceptibility Testing for Clinically Significant Fungi (by CACMLE) (Online CE Course) ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
Biomarkers are used to detect, predict disease susceptibility and monitor disease progression for infectious diseases, cancer, metabolic diseases, central
Vähäkangas K. & Länsimies E. (2004). Suostumuskäytäntö ja henkilöllisyyden suoja geenipankkitutkimuksissa. Suomen Lääkärilehti 14/2004. pp. 1552-1554. Vähäkangas K: (2008). Molecular Epidemiology and Ethics: Biomarkers for Disease Susceptibility. Kirjassa: Molecular Epidemiology of Chronic Diseases, Chris Wild,Paolo Vineis,Seymour Garte (eds.). ...
A new study at Southwest Foundation for Biomedical Research is looking for genetic factors that increase our susceptibility to some of this countrys most common chronic infections, and ultimately, how that susceptibility might be linked to our risk for cardiovascular disease.
Many scientists now suspect that a vast majority of Parkinsons cases are caused by interplay between an inherited genetic susceptibility and environm
Bill Dinger goes over the 2017 OWASP Top 10 vulnerabilities and how they apply to ASP.NET, including a demo of each vulnerability, the risk it poses, how to detect the attack, and how to mitigate it.
CVE-2009-1141 Vulnerability Information. Learn everything about CVE-2009-1141. Vulnerability Detection, Vulnerability scanning and available solutions.