TY - JOUR. T1 - Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity. AU - Chien, Ming Hsien. AU - Ying, Tsung Ho. AU - Hsieh, Yih Shou. AU - Chang, Yu Chao. AU - Yeh, Chia Ming. AU - Ko, Jiunn Liang. AU - Lee, Wen Sen. AU - Chang, Jer Hua. AU - Yang, Shun Fa. PY - 2012/3. Y1 - 2012/3. N2 - Oral cancer mortality has increased during the last decade due to the difficulties in treating related metastasis. Dioscorea nipponica Makino, a popular folk medicine, exerts anti-obesity and anti-inflammation properties. However, the effect of this folk medicine on metastasis of oral cancer has yet to be fully elucidated. The present study demonstrates that D. nipponica extracts (DNE), at a range of concentrations (0-50 μg/mL), concentration-dependently inhibited migration/invasion capacities of human oral cancer cells, HSC-3, without cytotoxic effects. The ...
Accatino L, Pizarro M, Solis N, Koenig C. Effects of diosgenin, a plant derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat. Hepatology. 1998;28(1):129-140.. Ali Z, Smillie TJ, Khan IA. Cholestane steroid glycosides from the rhizomes of Dioscorea villosa (wild yam). Carbohydr Res. 2013;370:86-91.. Aumsuwan P, Khan SI, Khan IA, et al. The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro. Arch Biochem Biophys. 2016;591:98-110.. Aumsuwan P, Khan SI, Khan IA, et al. Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells. In Vitro Cell Dev Biol Anim. 2015;51(1):59-71.. Bhandari MR, Kawabata J. Bitterness and toxicity in wild yam (Dioscorea spp.) tubers of Nepal. Plant Foods Hum Nutr. 2005;60(3):129-35.. Boban PT, Nambisan B, Sudhakaran PR. Hypolipidaemic effect of chemically ...
The invention discloses a selenium-enriched Chinese yam cereal solid beverage and a preparation method thereof. The selenium-enriched Chinese yam cereal solid beverage is prepared from selenium-enriched Chinese yam whole flour, selenium-enriched small red beans, selenium-enriched corn, selenium-enriched black soya beans, selenium-enriched black peanuts, selenium-enriched red skin peanuts and konjac powder according to a mass ratio. The method includes the steps that firstly, the raw materials are subjected to preliminary pre-selection treatment, and then rinsing impurity removal and soaking are carried out; secondly, the raw materials are fed into a jacketed kettle to be boiled out; thirdly, clear water is added, thick liquid is continuously ground through a colloid mill, and residues are filtered and removed; fourthly, the konjac powder is added in filtered emulsion serous fluid in proportion; fifthly, feed liquid is homogenized through a high-pressure homogenizer; sixthly, spray drying is conducted;
Dioscin, a typical steroid saponin, is isolated from Dioscorea nipponica Makino and Dioscorea zingiberensis Wright. It has estrogenic activity and many studies have also reported that dioscorea plants have an effect in preventing and treating osteoporosis. However, the molecular mechanisms underlying their effect on osteoporosis treatment are poorly understood. Therefore, the present study aims to investigate the mechanism (s) by which dioscin promotes osteoblastic proliferation and differentiation in mouse pre-osteoblast like MC3T3-E1 cells and human osteoblast-like MG-63 cells. We found that dioscin (0.25 μg/ml, 0.5 μg/ml, and 1.0 μg/ml) promoted MC3T3-E1 cells and MG-63 cells proliferation and differentiation dose dependently. Western blot analysis results showed that estrogen receptor α (ER-α), estrogen receptor β (ER-β), β-catenin and Bcl-2 protein expression increased after MC3T3-E1 cells were treated with dioscin. Quantitative reverse transcription-polymerase chain reaction (RT-PCR)
Wild yam is a plant also known as American Yam, Atlantic Yam, Barbasco, China Root, Chiense Yam, Colic Root, Devils Bones, DHEA Naturelle, Dioscorea, Dioscorea alata, Dioscorea batatas, Dioscorea composita, Dioscorea floribunda, Dioscorea hirticaulis, Dioscorea japonica, Dioscorea mexicana, Igname Sauvage, Igname...
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Yams are members of the Dioscoreae family. Depending upon the yam variety, of which there are about 200, its flesh may be of varying colours including white, ivory, yellow or purple while its thick skin may either be white, pink or brownish-black. Their shape is long and cylindrical (oftentimes having offshoots referred to as "toes") while their exterior texture is rough and scaly. Yams have a very starchy and slippery texture and when cooked, will either be creamy or firm, depending upon the variety. Their taste is earthy and hardy, with most varieties having minimal, if any, sweetness. Specific types of yams include Dioscorea alata (Hawaiian yam), Dioscorea batatas (Korean yam) and Dioscorea esculenta (sweet yam). Protection against Cardiovascular Disease Yams are a good source of vitamin B6. Vitamin B6 is needed by the body to break down a substance called homocysteine, which can directly damage blood vessel walls. Individuals who suffer a heart attack despite having normal or even low ...
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Potential of Trichoderma harzianum, Pseudomonas syringae and Pseudomonas chlororaphis for the control of rot in post harvest yams was investigated. Treatments comprising two pathogenic fungi, each paired with three biological antagonists were set up. Degree of rot was evaluated by calculation of percentage reduction by the antagonists. Pathogenicity test showed that Botryodiplodia theobromae and Fusarium solani induced rot in healthy yam tubers after fourteen days of inoculation, B. theobromae being the more virulent with 85.5% rot. Reduction of rot ranged from 53.5 - 84.5% in B. theobromae when paired with the biological antagonists and in F. solani, the rot reduction ranged from 59.6 - 87.1%. Generally, T. harzianum was the most effective in controlling B. theobromae and F. solani. The use of these three biological antagonists, recommends their use in the control of rot in post harvest yam tubers.
BACKGROUND: Dioscorins are the major storage proteins of yam tubers. However, the molecular nature of their heterogeneity in tubers has not been fully elucidated. In this study the authors isolated the dioscorin gene families of Dioscorea japonica and Dioscorea pseudojaponica, performed matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF-MS) and elucidated which dioscorin isoforms are the major constituents in tubers.. RESULTS: The dioscorin gene families of D. japonica (Dj-dioA1-Dj-dioA4, Dj-dioB1 and Dj-dioB2) and D. pseudojaponica (Dp-dioA1-Dp-dioA5 and Dp-dioB1) were cloned from cDNA libraries of yam tubers. The dioscorins isolated from Dioscorea alata (Da-dioscorins), D. japonica (Dj-dioscorins) and D. pseudojaponica (Dp-dioscorins) were mainly monomers, with a few dimers. The monomers contained one intramolecular disulfide bond (Cys28-Cys187) and belonged to Class A dioscorins with two cysteine residues. The dimers consisted of Class B dioscorins with ...
The bulbils of selected cultivars tend to be angular with a flattened shape and a skin-colour which evokes the name turkey liver yam. They may attain as much as 2 kg in weight but an average weight is about 0.5 kg. Races with increased bulbil production tend to show a reduction of the tuber, and in those with the highest bulbil return the tuber is but a woody rootstock ...
Wild yam (Dioscorea villosa) is a versatile herb that might not win any beauty contests. Its rootstocks grow crooked and bear horizontal branches of long, creeping runners with thin reddish-brown stems that grow to a length of over 30 feet.
It is not clear whether blood sugar is lowered by Dioscorea villosa (wild yam). Dioscoretine, a compound found in the related species Dioscorea dumentorum (bitter or African yam), has been shown to lower blood sugar levels, but this has not been shown for Dioscorea villosa. Effects on blood sugar in humans have not been reported. Nonetheless, caution is advised when using medications that may also lower blood sugar. People taking diabetes drugs by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.. Early evidence suggests that wild yam lowers blood levels of indomethacin, a non-steroidal anti-inflammatory drug, and reduces irritation of the intestine caused by indomethacin. Human studies have not been reported in this area and it is not clear if wild yam affects the blood levels of other anti-inflammatory drugs such as ibuprofen (Advil®, Motrin®).. Diosgenin, thought to be the active substance in wild yam, has been found in ...
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Sigma-Aldrich offers abstracts and full-text articles by [Xu Pang, Di Wen, Yang Zhao, Cheng-Qi Xiong, Xiao-Qin Wang, Li-Yan Yu, Bai-Ping Ma].
Wild yam may offer some benefits. It is believed that wild yam can stimulate the ovaries to produce a balance of progesterone and estrogen, making it a popular alternative to synthetic hormones for women. Though wild yams do contain diosgenin, a precursor to progesterone that can be used to synthesize the hormone in a laboratory, there is some doubt about the bodys ability to make the conversion to progesterone naturally. Wild yam is available in tablets, capsules, tinctures, and teas. Pills and tinctures should be taken with food to reduce the risk of stomach irritation and nausea. Since wild yam contains a potentially toxic substance known as dioscorin and can interact with prescription hormones such as estrodiol, consult a knowledgeable healthcare provider before using products that contain wild yam.. ...
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Original articles. Pfalzgraff A, Heinbockel L, Su Q, Brandenburg K, Weindl G (2017) Synthetic anti-endotoxin peptides inhibit cytoplasmic LPS-mediated responses. Biochem Pharmacol. DOI: 10.1016/j.bcp.2017.05.015. Su Q, Pfalzgraff A, Weindl G (2017) Cell type-specific regulatory effects of glucocorticoids on cutaneous TLR2 expression and signalling. J Steroid Biochem Mol Biol. DOI: 10.1016/j.jsbmb.2017.03.023. Su Q, Grabowski M, Weindl G (2017) Recognition of Propionibacterium acnes by human TLR2 heterodimers. Int J Med Microbiol 307: 108-12. DOI: 10.1016/j.ijmm.2016.12.002. Pfalzgraff A, Heinbockel L, Su Q, Gutsmann T, Brandenburg K, Weindl G (2016) Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune responses in skin cells and promote keratinocyte migration. Sci Rep 6: 31577. DOI: 10.1038/srep31577. Zhang X, Ito Y, Liang J, Su Q, Zhang Y, Liu J, Sun W (2013) Preparative isolation and purification of five steroid saponins from Dioscorea zingiberensis C.H.Wright ...
COMMON NAMES: Wild yam, Colic-root, Rheumatism-root.. Botanical Source.-Dioscorea villosa, Linné. This is an herbaceous, slender vine, found throughout the United States, but more common in the central and southern portions. The stem is a smooth green twiner, about the size of a goose-quill, twining from the right to the left, over fences, bushes, etc. The leaves are symmetrical and heart-shaped, gradually tapering to a sharp, acuminate point, and are borne on leaf stalks from 2 to 4 inches long. The lower leaves are in whorls of 4 or 5, with intervals of from 6 inches to a foot between, while those on the upper part of the vine are irregularly alternate. The margins of the leaves are entire and wavy in the larger leaves. The veins are generally 9, quite prominent, and gradually diverge from the top of the leaf-stalk. The under side of the leaves is clothed with a thick pubescence. The flowers appear in June or July, are dioecious, very small, and greenish-yellow. The male flowers are in ...
Dong quai, wild yams, licorice, and Macefen are herbs which help regulate the levels of estrogen and progesterone. These are not the hormones themselves, but only regulate the hormonal balance between the two hormones.. Dong Quai: Dong quai has been called the "female ginseng" because of its use in gynecology. Dong quai is a powerful Chinese tonic herb made from the Angelica Sinesis plant which nourishes the blood and supports the menstrual cycle. It is used to treat amenorrhea or the cessation of menstrual bleeding which is the hallmark of menopause. Although it is a natural remedy, it is a powerful herb and should not be given to individuals prone to excessive bleeding.. Wild Yams: Human estrogen itself has been synthesized from the Mexican wild yam. Some of the replacement hormones for estrogen are made from wild yams. The body can synthesize estrogen from wild yams the same way it is synthesized industrially. In one study with rats, wild yams were shown to be effective whereas the extract of ...
Learn more about Wild Yam uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Wild Yam
Organika Wild Yam & Soy Isoflavone Cream is derived from Wild Yam which provides natural progesterone support for women experiencing female hormonal imbalances.
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... | Herbal Products | Silverton, Pretoria | Possesses Anti Oxidant Properties. Lowers Elevated Serum Triglycerides Levels. Alleviates The Nausea Associated With Morning Sickness That Often Occurs During Pregnancy. Relaxes Muscle Spasms. Reduces Inflammation. Promotes Perspiration. Contains Compounds Similar To The Hormone Progesterone. Good For Colic, Gallbladder Disorders, Hypoglycaemia, Irritable Bowel Syndrome, Kidney Stones, Neuralgia, Rheumatism And Female Disorders. Including Premenstrual Syndrome And Menopause-related Symptoms. Ingredients: Wild Yum (Dioscorea Villosa).
... Dioscorea villosa Part to full shade; moderately wet to medium moisture level; prefers light rich soil but will also grow in sandy, rocky or clay soils; pH tolerant. 5-15 feet height, blooms spring into summer; greenish yellow flowers. Growth Rate: ? Maintenance: Easy to grow Propagation: Seed germination code C(60) Native…
Wild yam (Dioscorea villosa) is a herbal remedy used for centuries to treat menstrual cramps, PMS, rheumatism, and digestive problems. Does it work?
The Plant Profiler provides detailed information and bioactive compounds for numerous different plant species. The high quality, evidence-based information on each Plant Profiler page is gathered by Natural Standard, the authority on integrative medicine.
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We expressed and purified a recombinant P. pyralis luciferase with N-terminal His-tags. The silanized Ni or Cu-loaded magnetic particles were prepared and used to assemble the His-tagged P. pyralis luciferase. This enzyme immobilized on functionalized magnetic nanoparticles (MNPs) via electrostatic interactions of His-tag with Ni2+/Cu2+ ions on the surface of MNPs using simple one step method. These particles were also used for purification of recombinant luciferase from crude extract of cell lysate. Effect of incubation time and amount of MNPs in bioluminescent activity were investigated to determine optimum condition for immobilization. Several properties of immobilized luciferase were studied and compared with free enzyme. Immobilization has shown different effects on Km for ATP and luciferin. In both immobilized form, Km(ATP) was increased while Km(luciferin) was shown decreases. Optimal temperature of both immobilized luciferase increased to 30 ºC while thermal stabilities have not shown
The House of Representatives wednesday passed a motion mandating its Committees on Agricultural Production and Services and Customs and Excise to investigate the Minister of Agriculture and Rural Development, Chief Audu Ogbeh on why the law prohibiting the exportation of yam tubers was flagrantly disregarded, thereby causing immense embarrassment to the country.
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Chinese yam can improve high blood glucose effectively, Composition of bond-slip is formed by mucoprotein. Mucoprotein can wrap up other foods in intestinal tract, making it be absorbed gradually. This function can restrain dramatic elevation after meal and avoid over secretion of insulin, and make blood glucose get better control. Chinese yam contains effective element for insulin secretion. And vitaminB1, vitaminB2, these elements impost the metabolism of glucose in the blood. Whats more, chinese yam also contains amylase, it is a kind of amylase that can digestive glucose, and make no glucose deposit in the blood ...
Yams of African species must be cooked to be safely eaten, because various natural substances in yams can cause illness if consumed raw. The most common cooking methods in Western and Central Africa are by boiling, frying or roasting.[30]. Among the Akan of Ghana, boiled yam can be mashed with palm oil into eto in a similar manner to the plantain dish matoke, and is served with eggs. The boiled yam can also be pounded with a traditional mortar and pestle to create a thick, starchy paste known as iyan (pounded yam) or fufu which is eaten with traditional sauces such as egusi and palm nut soup. Another method of consumption is to leave the raw yam pieces to dry in the sun. When dry, the pieces turn a dark brown color. These are then milled to create a brown powder known in Nigeria as elubo. The powder can be mixed with boiling water to create a thick starchy paste, a kind of pudding known as amala, which is then eaten with local soups and sauces. Yams are a primary agricultural and culturally ...
Doctors can prescribe natural progesterone for people with low levels, such as Crinone and Prometrium. The manufacturer produces these in a lab from a natural compound called diosgenin. Crinone and Prometrium are available in gel and capsule form.. However, many products are also available that serve as natural forms of progesterone. These products are made from soybeans or a wild and inedible Mexican yam called Diascorea villosa.. These wild yam products are available over the counter as a topical or vaginal cream or as capsules.. Even though some people consider wild yam products to be a natural form of progesterone, they do not contain any progesterone. They contain a chemical that can a series of chemical reactions that occur in a laboratory can convert to progesterone. Therefore, taking a product that contains only wild yam will not provide any progesterone.. People using progesterone supplements should also note that wild yam products are not sources of progesterone and the United States ...
Doctors can prescribe natural progesterone for people with low levels, such as Crinone and Prometrium. These are produced in a lab and made from a natural compound called diosgenin. Crinone and Prometrium are available in gel and capsule form.. However, there are also many products marketed as natural forms of progesterone. These products are made from soybeans or a wild and inedible Mexican yam called Diascorea villosa.. These wild yam products are available over the counter as a topical or vaginal cream or as capsules.. Even though some people consider wild yam products as a natural form of progesterone, they do not contain any progesterone. They contain a chemical that can be converted to progesterone, but only through a series of chemical reactions that occur in a laboratory. Therefore, taking a product that contains just wild yam will not provide any progesterone.. Users should also note that wild yam products are not sources of progesterone and the United States Food and Drug and ...
Wild Yam Cream has be publicized as a treatment for menopause, hot flashes, night sweats, PMS, headache cerebral pains, state of mind swings, richness, bigger bosoms, coronary illness, and osteoporosis. The general population who offer these items guarantee they contain "regular hormones" and "hormone like mixes." To many individuals, experiencing these conditions, this appears like the ideal "medication" to help them. Much of the time these creams are not viable on the grounds that the item publicized does not contain the hormone guaranteed. The truth of the matter is, there is no progesterone in the wild yams, nor can your body influence progesterone from the hormone to like compound, diosgenin, in the wild yam. Things being what they are, the reason is there such disarray about this? Monografias Prontas. The reason this deception exists is on the grounds that a couple of decades prior, wild yams were reaped and filtered to create the middle of the road concoction, diosgenin, for progesterone ...
Chinese Wild Yam or Cinnamon Vine grows in the US, Caribbean, Central America, South America, and Asia, and other countries in moist loamy soils that produces
In herbal medicine Wild Yam is a remedy that can be used to relieve intestinal colic, to soothe diverticulitis, ease dysmenorrhoea and ovarian and uterine pains.
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Boxshall, G.; Walter, T. Chad (2011). Canuella bulbifera Chislenko, 1971. In: Walter, T.C. & Boxshall, G. (2017). World of Copepods database. Accessed through: World Register of Marine Species at http://www.marinespecies.org/aphia.php?p=taxdetails&id=349946 on 2017-12- ...
(Dioscorea spp.) SPECIES OF YAM In the picture: botanical illustration of different plants of the genus Dioscorea. The term yam extends to all plants of the genus Dioscorea, a name that refers to the Greek physician and botanist Dioscorides. There are over 600 species of yam, of which only 12
Gracillin is a kind of steroidal saponin isolated from the root bark of wild yam Dioscorea nipponica with antitumor agent. - Mechanism of Action & Protocol.
Dasbak M.A., Manggoel W. and Dawang C.N. Evaluation of nursery sprouting media for the minisetts of some Dioscorea rotundata yam cultivars and the field establishment of sprouted minisetts in Garkawa, Plateau State, Nigeria [View Abstract] [Full Article - PDF] [Download Full Text] pp. 481-484 (51 KB) Int. Res. J. Agric. Sci. Soil Sci. 2011 Vol.1,No.11 ...
Results indicated that the HFD group had significantly accelerated weight gain and higher final body weight compared to the ND group. However, subjects fed the DB supplement had a significant decrease in body weight compared to the HFG, with no discernible difference between the DB dosage groups. Additionally the test groups with DB supplementation displayed significantly reduced visceral fat accumulation.. Examination of adipose gene expression showed that regulators of adipogenic factors were significantly reduced in DB extract fed mice. Likewise the expression of proinflammatory cytokines in adipose tissue was decreased significantly. These findings are of particular interest as proinflammatory cytokines in adipose tissue have been linked to cardiovascular disease in obese patients. Leptin levels were also investigated as an indicator for obesity; levels were shown to be greatly increased in the HFD test group resulting in suppression of cytokine signalling. Supplementation with DB at the ...
Kacang soya dalam Bio~Ever Nano Cream mengandungi zat-zat semula jadi dan bahan-bahan antioksidan yang serupa dengan hormon wanita yang amat berkesan dalam mengatasi proses penuaan. Diosgenin yang terdapat dalam Bio~Ever Nano Cream pula dapat mengaktifkan hormon-hormon badan seperti progesteron, testosteron, kortisol dan sebagainya. Hormon-hormon ini dapat menyelaraskan sistem badan termasuklah fungsi metabolisme dan sistem saraf, di samping melambatkan penuaan organ-organ badan dan memelihara fungsi fisiologi badan. Selain itu, rumusan yang terkandung dalam Wild Yam (Dioscorea Villosa) dapat memelihara kelenjar tiroid, kelenjar adrenal, ovari dan testis serta kelenjar-kelenjar endokrin yang lain dan membolehkan kelenjar-kelenjar ini berfungsi secara lancar, seterusnya menggalakkan sistem hormon berfungsi dengan baik dan memperoleh badan yang sihat. ...
Many women are being encouraged to purchase and use Wild Yam Cream said to offer relief from premenstrual and menopausal symptoms. The preparation is made by a company called NATURAL efx and is promoted with materials that include testimonials, the recommendation of a Dr. Betty Kamen, and citations of medical literature purported to support the claims being made.. According to this promotional literature, Hormonal Imbalance!!! and Estrogen Dominance cause Cramps, Migraines, Bloat, Breast Tenderness, Hot Flashes, Cant Lose Weight, Lack of Energy, Depression -- Mood Swings, Fibroid Tumors, Endometriosis -- Infertility, Family History Female -- Related Cancer, Foggy Thinking, Perimenopause, [and] Losing Height. These conditions are said to be effectively treated by the application of the product twice daily. Also claimed is that the cream Enhances libido, Improves energy, stamina and endurance, Stimulates the bodys own production of estrogen, progesterone, testosterone, [and] other ...