Pepicelli O, Fedele E, Bonanno G, Raiteri M, Ajmone-Cat MA, Greco A, Levi G, Minghetti L. In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E2 extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms. Journal of neurochemistry 2002;81(5):1028-1034 ...
Effect of Dietary β-1,3/1,6-glucan Supplementation on Growth Performance, Immune Response and Plasma Prostaglandin E2, Growth Hormone and Ghrelin in Weanling Piglets - ${\beta}$-1,3/1,6-glucan;Growth Performance;Immune Response;$PGE_2$;Ghrelin;Weanling Piglets;
Mucosal prostaglandin E2 levels in patients with the gastric ulcer before and after their ulcers were healed. Both the antral and duodenal PG E2 are significant
Dinoprostone - Get up-to-date information on Dinoprostone side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Dinoprostone
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Principal Investigator:SUGIMURA Motoi, Project Period (FY):2007 - 2009, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Obstetrics and gynecology
Dinoprostone: The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Prostin E2 with NDC 0009-0827 is a a human prescription drug product labeled by Pharmacia And Upjohn Company Llc. The generic name of Prostin E2 is dinoprostone.
Dinoprostone is used for several purposes, such as preparing the cervix for delivery or causing an abortion. This eMedTV page examines the various forms of this drug, along with the specific uses for each product. It also covers side effects and dosing.
Cyclooxygenase-2 (COX-2)-dependent prostaglandin E2 (PGE2) synthesis exacerbates occlusive and aneurysmal vascular disease by inducing macrophage proteinase and...
Inside a WBC we have a transcription factor called NFKB. In the cytosol, NFKB is normally inactivated by IKB. When a viral/bacteria protein stimulates an inflammatory response, the IKB is degraded and we have free NFKB. This translocates in the nucleus where is acts as a transcription factor, to increase cytokines, adhesion molecules, and COX-2. -Cytokines: fight pathogens but can also cause tissue damage. -Adhesion molecules: ICAM/VCAM: binds to the endothelial cells, which can then go into the tissue and fight the pathogen. -COX-2: AA is the subtrate for COX-2, which produces PGE. This causes dilation of the vessels, warmth, tenderness. ...
Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2. The synthase generating PGE2 is a membrane-associated protein. Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene: Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proceedings of the National Academy of Sciences. 105 (32): 11110-11115. doi:10.1073/pnas.0802894105. PMC 2516235 . PMID 18682561. Murakami M, Nakatani Y, Tanioka T, Kudo I (August 2002). Prostaglandin E synthase. Prostaglandins Other Lipid Mediat. 68-69: 383-99. doi:10.1016/S0090-6980(02)00043-6. PMID 12432931. Park JY, Pillinger MH, Abramson SB (June 2006). Prostaglandin E2 synthesis and secretion: the role of ...
TY - JOUR. T1 - Diphlorethohydroxycarmalol, isolated from Ishige okamurae, increases prostaglandin E2 through the expression of cyclooxygenase-1 and -2 in HaCaT human keratinocytes. AU - Kang, Gyeoung Jin. AU - Han, Sang Chul. AU - Koh, Young Sang. AU - Kang, Hee Kyoung. AU - Jeon, You Jin. AU - Yoo, Eun Sook. N1 - Copyright: Copyright 2013 Elsevier B.V., All rights reserved.. PY - 2012. Y1 - 2012. N2 - Prostaglandin (PG) E2, the most abundant prostaglandin in the human body, is synthesized from arachidonic acid via the actions of cyclooxygenase (COX) enzymes. PGE2 exerts homeostatic, cytoprotective, inflammatory, and in some cases anti-inflammatory effects. Also, it has been reported that PGE2 is involved in hair growth. Diphlorethohydroxycarmalol (DPHC) is a phlorotannin compound isolated from the brown algae Ishige okamurae, with various biological activities in vitro and in vivo. In this study, the biological effect and mechanism of action of DPHC on prostaglandin synthesis in HaCaT human ...
Animal studies lasting several weeks at high doses have shown that prostaglandins of the E and F series can induce proliferation of bone. Such effects have also been noted in newborn infants who have received prostaglandin E1 during prolonged treatment. There is no evidence that short term administration of PROSTIN E2 Vaginal Suppository can cause similar bone effects.. As in spontaneous abortion, where the process is sometimes incomplete, abortion induced by PROSTIN E2 may sometimes be incomplete. In such cases, other measures should be taken to assure complete abortion.. In patients with a history of asthma, hypo-or hypertension, cardiovascular disease, renal disease, hepatic disease, anemia, jaundice, diabetes or history of epilepsy, dinoprostone should be used with caution.. Dinoprostone administered by the vaginal route should be used with caution in the presence of cervicitis, infected endocervical lesions, or acute vaginitis.. As with any oxytocic agent, dinoprostone should be used with ...
The commensal flora can promote both immunity to pathogens and mucosal inflammation. How commensal-driven inflammation is regulated in the context of infection remains poorly understood. Here, we show that during acute mucosal infection of mice with Toxoplasma gondii, inflammatory monocytes acquire a tissue-specific regulatory phenotype associated with production of the lipid mediator prostaglandin E2 (PGE2). Notably, in response to commensals, inflammatory monocytes can directly inhibit neutrophil activation in a PGE2-dependent manner. Further, in the absence of inflammatory monocytes, mice develop severe neutrophil-mediated pathology in response to pathogen challenge that can be controlled by PGE2 analog treatment. Complementing these findings, inhibition of PGE2 led to enhanced neutrophil activation and host mortality after infection. These data demonstrate a previously unappreciated dual action of inflammatory monocytes in controlling pathogen expansion while limiting commensal-mediated ...
Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term - The Cochrane database of systematic reviews - Vol. 6 - p.CD003101
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In our studies, we showed that inhibition of LPS-stimulated ROS production in BMDM also selectively inhibited the production of PGD2, but not its isomer PGE2. LPS-induced PGD2 production in BMDM was mediated via H-PGDS isomerase, but not L-PGDS. LPS-induced H-PGDS-mediated PGD2 production was sensitive to and dependent on the NOX-generated ROS in BMDM. In contrast, the LPS-induced PGE2 production in BMDM was ROS independent.. To our knowledge, this is the first report of the role of ROS in differential regulation of LPS-induced PGD2 and PGE2 production. The novel finding of our study is that the modulation of intracellular ROS levels in macrophages could selectively regulate LPS-induced production of PGD2, but not PGE2. Therefore, it is impossible that the ROS or any NOX/ROS inhibitors exert their selective effects on PGD2 production via the modification of COX-2 enzyme in BMDM. If there is any modifications of the COX-2 protein expression or its enzyme activity by the above inhibitors or H2O2, ...
The cyclooxygenase (COX) isoforms COX-1 and COX-2 convert arachidonic acid to prostaglandin (PG) precursors and are a limiting step in PG production. Interleukin-1beta (IL-1beta) treatment of type II A549 cells increases PGE2 synthesis via transcription- and translation-dependent induction of COX-2. …
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
Mgt: XALATAN is the first of a new class of glaucoma drugs called prostaglandins. Your body produces prostaglandins naturally for many things. In the eye, one particular prostaglandin has been shown to help the fluid in the eye flow out by opening alternative drainage canals, thus keeping the eye pressure from becoming elevated. Xalatan works similarly to this natural prostaglandin and is believed to increase the fluid outflow through this secondary drainage system ...
Aluminum enhances the stimulatory effect of NaF on prostaglandin E2 synthesis in a clonal osteoblast-like cell line, MOB 3-4, in vitro. (1989 ...
I went to my OB yesterday for my first weekly appointment and they did my GBS test. Ill get those results back on Friday so Ill update you next week. He asked me all the normal questions but, again, added a new shocking on in just to make sure I was paying attention. He asked if I would like to plan to have my membranes stripped to help speed up the end of my pregnancy. Stripping membranes is when a physician uses a finger to basically separate the water bag from the cervix which releases prostaglandins to help induce labor. This method is definitely not a sure way to start labor but if everything is progressing well, it shouldnt harm a pregnancy either. But either way, I freaked out. Im totally not ready for this baby to show up any earlier than we have planned ...
Complete information for PTGES3 gene (Protein Coding), Prostaglandin E Synthase 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Wielgos M, Szymusik I, Kosinska-Kaczynska K, Suchonska B, Kaminski P, Banaszek-Wysoczanska A, Bomba-Opon D, Szpotanska M. The influence of dinoprostone on uterine cervix ripening and the course of labor. Neuro Endocrinol Lett. 2007 Aug; 28(4): 513-517 ...
I have tried to collect a number of links to local media outlets, found here on our website. There are a shocking number of them, and they vary widely in quality. Corrections and comments welcome (did I miss any?). There are a number of upcoming county meetings, click here. Sample: SJC Council (Mar 20, 21) Solid Waste Advisory committee (Mar 23), Building Advisory council mtg (Mar 23), Veterans Advisory board meeting (Mar 31), etc.. Seattle flounders in dealing with its housing crisis with a number of measures that only discourage investment in housing: here and here. (Seattle Times). Locally in SJC we are struggling with this issue, and liberals have proposed vacation rental permit changes.. Tuesday, March 29th Bill Watson is holding a public hearing, including a comprehensive plan update. Journal reports.. Jill Meyer wrote a thoughtful letter to the editor, here. She has received some pushback. Those who share her concerns should consider speaking up. I do not mean to target Ms. OClair for ...
p,Hyperproduced prostaglandin E,sub,2,/sub, by cyclooxygenase-2 and microsomal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that ,i,Dioscorea japonica,/i, extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and induced apoptosis in lung carcinoma A549 cells. In the present study, we investigated the effects of ,i,Dioscorea japonica,/i, on squamous cell carcinoma of mouse skin. ,i,Dioscorea japonica,/i, feeding and ,i,Dioscorea japonica,/i, extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1β and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration. Immunohistochemical analyses showed the immunoreactivities of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in tumor keratinocytes and stronger immunoreactivities of cyclooxygenase-2 ...
hypothetical protein, gbf1, Anapl_04335, AS27_01565, AS28_01193, C79137, C9orf15, CB1_000576027, D623_10025025, gamma-interferon-activated transcriptional element-binding factor 1, GATE-binding factor 1, GBF-1, H920_19196, I79_014770, M91_12705, M959_12051, MDA_GLEAN10019304, membrane-associated prostaglandin E synthase 2, membrane-associated prostaglandin E synthase-2, microsomal prostaglandin E synthase 2, microsomal prostaglandin E synthase-2, Mpges2, MPGES-2, mPGE synthase-2, N300_09271, N301_12743, N302_13172, N303_06092, N305_09010, N306_14810, N307_02442, N308_10508, N311_11677, N312_00533, N320_07005, N321_11509, N322_00413, N324_09565, N325_00199, N326_00389, N327_11175, N328_09700, N329_10988, N330_00570, N331_03110, N332_07603, N333_00239, N334_00603, N335_09322, N336_03658, N339_06101, N340_07113, N341_11017, PAL_GLEAN10012478, PANDA_003194, pges2, prostaglandin E receptor 2, prostaglandin E synthase 2-like protein, prostaglandin-H(2) E-isomerase, TREES_T100004307, UY3_04702, ...
Microsomal prostaglandin E synthase-1 (mPGES-1) or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53-induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. Prostaglandin E synthase GRCh38: Ensembl release 89: ENSG00000148344 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000050737 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Jakobsson PJ, Thorén S, Morgenstern R, et al. (1989). Identification of human prostaglandin E synthase: a microsomal glutathione-dependent, inducible enzyme, constituting a potential ...
Jegerschold, C.; Pawelzik, S. -C.; Purhonen, P.; Bhakat, P.; Gheorghe, K. R.; Gyobu, N.; Mitsuoka, K.; Morgenstern, R.; Jakobsson, P. -J.; Hebert, H. (2008). Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proceedings of the National Academy of Sciences. 105 (32): 11110-11115. doi:10.1073/pnas.0802894105. PMC 2516235. PMID 18682561 ...
Prostaglandin E synthase (PGES) including isoenzymes of membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES) is the recently identified terminal enzyme of the arachidonic acid cascade. PGES converts prostaglandin (PG)H2 to PGE2 downstream of cyclooxygenase (COX). We investigated the expression of PGES isoenzyme in articular chondrocytes from patients with osteoarthritis (OA). Chondrocytes were treated with various cytokines and the expression of PGES isoenzyme mRNA was analyzed by the reverse transcription-polymerase chain reaction and Northern blotting, whereas Western blotting was performed for protein expression. The subcellular localization of mPGES-1 was determined by immunofluorescent microscopy. Conversion of arachidonic acid or PGH2 to PGE2 was measured by enzyme-linked immunosorbent assay. Finally, the expression of mPGES-1 protein in OA articular cartilage was assessed by immunohistochemistry. Expression of mPGES-1 mRNA in chondrocytes was significantly induced by
Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor α3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin ...
Many human cancers express elevated levels of cyclooxygenase-2 (COX-2), an enzyme responsible for the biosynthesis of prostaglandins. Available clinical data establish the protective effect of COX-2 inhibition on human cancer progression. According to the study by Medical College of Georgia, showed that the COX-2 product prostaglandin E(2) (PGE(2)) acts on cognate receptor EP4 to promote the migration of A549 lung cancer cells. Treatment with PGE(2) enhances tyrosine kinase c-Src activation, and blockade of c-Src activity represses the PGE(2)-mediated lung cancer cell migration. PGE(2) affects target cells by activating four receptors named EP1 to EP4. Use of EP subtype-selective ligand agonists suggested that EP4 mediates prostaglandin-induced A549 lung cancer cellmigration, and this conclusion was confirmed using a short hairpin RNA approach to specifically knock down EP4 expression(7 ...
Inflammation comprises the reaction of the body to injury, in which a series of changes of the terminal vascular bed, blood, and connective tissue tends to eliminate the injurious agent and to repair the damaged tissue. It is a complex process, which involves the release of diverse regulatory mediators. The current anti-inflammatory agents are challenged by multiple side effects and thus, new effective therapies are highly needed. The aim of this review is to summarize the described microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors or transcriptional suppressors from medicinal plants, which could be an ideal approach in the management of inflammatory disorders, but need further clinical trials in order to be ultimately validated ...
Fungsi hormon prostaglandin dalam vesikula seminalis, prostaglandin e2 receptor antagonist, prostaglandin analogues mechanism of action, prostaglandin pill to induce labor, prostaglandin e1, prostaglandin f2 alpha side effects, prostaglandin action on kidney
N-(3,4-dichlorobiphenyl-4-yl)-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide: a microsomal prostaglandin E synthase-1 inhibitor; structure in first source
Ovulation is essential for successful reproduction. The ovulatory luteinizing hormone (LH) surge stimulates periovulatory follicles to produce prostaglandin E2...
Several lines of evidence show that production of PGE2 is enhanced during inflammation, and this lipid mediator can dramatically modulate the immune response (43). Given these observations and because myeloid-derived cells produce large amounts of proinflammatory lipid mediators, we investigated COX expression, PGE2 synthesis, and cytokine production by BM-DC. We reported that production of AA-derived metabolites did not require the addition of exogenous substrate, because BM-DC are able to produce PGE2 and LTB4 under the two experimental conditions, and these APC express cytosolic PLA2, which catalyzes the release of endogenous AA from the cell membrane. The expression of cPLA2 is up-regulated by LPS in a dose-dependent fashion, and an important liberation of AA was observed in LPS-treated BM-DC compared with control cells. These data are consistent with previous studies, which reported induction of cPLA2 by LPS in human leukocytes (44, 45). Analysis of COX expression shows that resting BM-DC ...
Welcome to the Prostaglandin E{1} Liposomal, PGE{1} information hub. Featuring active ingredients, dosages, related medications, and Prostaglandin E{1} Liposomal, PGE{1} forums.
CBR1_HUMAN RecName: Full=Carbonyl reductase [NADPH] 1; AltName: Full=15-hydroxyprostaglandin dehydrogenase [NADP(+)]; AltName: Full=NADPH-dependent carbonyl reductase 1; AltName: Full=Prostaglandin 9-ketoreductase; AltName: Full=Prostaglandin-E(2) 9-reductase ...
Serono was developing dual agonists of the prostaglandin E2 and E4 (EP2 and EP4) receptors for the treatment of asthma. The compounds are analogues of
SR GROUP - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of Hydroxy Prostaglandin E1 Chemical based in Delhi, India
[118 Pages Report] Check for Discount on Global Prostaglandin E2 Market Professional Survey Report 2017 report by QYResearch Group. Notes: Production, means the output of Prostaglandin E2 Revenue, means...
PTGES2 - PTGES2 (untagged)-Human prostaglandin E synthase 2 (PTGES2), transcript variant 1 available for purchase from OriGene - Your Gene Company.
deCODE genetics (a subsidiary of Amgen) was researching the potential for inhibitors of the EP3 receptor for prostaglandins E2 as novel, safer, non-opiate-based
We investigated the mechanisms by which inhibitors of prostaglandin G/H synthase-2 (PGHS-2; known colloquially as COX-2) increase… Expand ...
PROSTAGLANDIN-E2 LEVELS IN THE MEMBRANE SURROUNDING BULK AND PARTICULATE POLYMETHYLMETHACRYLATE IN THE RABBIT TIBIA - A PRELIMINARY-STUDY
BACKGROUND: Microsomal prostaglandin (PG) E(2) synthase-1 (mPGES-1) catalyzes isomerization of the cyclooxygenase product PGH(2) into PGE(2). Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis. The role of mPGES-1 in abdominal aortic aneurysm is unknown. METHODS AND RESULTS: The impact of mPGES-1 deletion on formation of angiotensin ...
PGE2, 1 ml. Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis.