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Glyphosate is a widely-used herbicide that is frequently found as a pollutant of soil and water runoffs. Glyphosate toxicity is controversial but a toxic synergy with other molecules could result in deleterious consequences for living organisms and for the human health. Using budding yeast (Saccharomyces cerevisiae) as a eukaryotic model organism, we report here a strong toxic synergy between glyphosate and 2,4-dinitrophenol (DNP), a phenolic compound derived from diesel engine's combustion and industrial pollutant found frequently in surface water and rainfall. Glyphosate concentrations below 600 mg/L did not affect yeast growth but exhibit dose-dependent toxicity in the presence of non-toxic DNP concentrations (below 1 mM). This so-called cocktail effect increases with DNP concentration. Yeast growth is totally abolished in the presence of the highest concentration of both molecules. We explored the implication of oxidative stress in this synergistic effect of glyphosate and DNP, by measuring
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Ubiquinol plays an important role in all energy-dependent processes and is essential for energy production. Coenzyme Q10 is found in every cell in the body ...
The effects of pharmacologically elevated metabolism on respiration and parabronchial gas exchange were studied in the anesthetized, spontaneously breathing duck using 2,4-dinitrophenol (DNP), injected in successive single doses of 1.2-2.5 mg per kg body mass. Oxygen uptake, MO2, increased with the cumulative amount of DNP, reaching a sevenfold resting level at the highest DNP level tolerated, 15 mg/kg. Ventilation increased nearly as much as MO2, mainly by an increase in respiratory frequency, fresp. Cardiac output increased somewhat less than MO2, mediated by increases in both cardiac frequency and stroke volume. Arterial blood-gases showed little change; however, mixed venous PO2 dropped significantly, and PCO2 increased significantly, with stimulated metabolism. Pulmonary diffusing capacity, DO2, showed a significant rise with MO2, beyond that expected from a reduction of functional lung heterogeneity. The results show that pharmacological stimulation of metabolism can evoke responses in the
The energy dependence of fragmentation in a collision cell was measured for 2100 peptide ions derived from the digestion of twenty four common proteins.
The present studies were designed to probe the role(s) of T cells in preventing or altering tolerance induction in hapten-specific B cells. This was accomplished by using hapten conjugates of normally immunogenic heterologous carriers to selectively inhibit 2,4-dinitrophenyl (DNP)-primed B cells in adoptive transfer experiments in vivo. The data provide strong indications that one critical role of T-cell participation in humoral responses to antigens is to circumvent the development of a tolerogenic signal that, in the absence of such T-cell function, might otherwise ensue after binding of the antigenic determinants by specific precursor B lymphocytes.. ...
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Sigma-Aldrich offers abstracts and full-text articles by [Nitasha R Bennett, Daniel B Zwick, Adam H Courtney, Laura L Kiessling].
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Development of a Cooled He*(23S) Beam Source for Measurements of State-Resolved Collision Energy Dependence of Penning Ionization Cross Sections: Evidence for a Stereo Specific Attractive Well Around Methyl Group in CH3CN.[J. Chem. Phys.,123,(2005),194308-1-194308-13]Takuya Horio, Masakazu Yamazaki, Satoshi Maeda, Takuro Hatamoto, Naoki Kishimoto, and Koichi ...
The role of ketosis in health and nutrition has been grossly misrepresented by those who would be well versed in nutrition. Learn why.
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Authors: Juan M. Gonzalez, DNP, APRN, AGACNP-BC, ENP-C, FNP-BC, CEN; Johis Ortega, PhD, APRN, ACNP-BC, ENP-BC, FNP-BC, FAAN, FAANP; Nichole Crenshaw, DNP, APRN, ACNP-BC, ANP-BC, FAANP; Lila de Tantillo, PhD, MS, APRN, FNP-BC ...
Exposure of normal mouse spleen cells in vitro to highly 125I-labeled dinitrophenyl (DNP)-protein carrier conjugates specifically inactivated cells able to mount an immune response to that hapten after in vivo challenge. The deletion was hapten specific and independent of the radioactive carrier to which the hapten was bound. DNP-binding cells were inactivated by radioactivity that was not part of the hapten, but was solely confined to the carrier moiety. The deletion of the anti-DNP response lasted 2-3 wk and could be specifically inhibited.. ...
Adrenaline on inside, at about 1: 100,000 - -.. _ _ _ _ _ -----,--~~ Control. . . . . . \Vhale neurohypophysealextract, on inside . . . . (1 mg. -------~~-- 4,5 3,5 Under atmospheric air. 3 161 158 Figures in individual experiments are for successive one·hour runs. with Na 24 ) proved always to exceed slightly the total current, as shown by the examples in Table VII. The Na+ efflux concurrently determined with Na 22 just about accounted for the difference between the two figures, so that the entire short-circuit current was attributable to active Na+ transport. HIOE 0:-;; 100 ~ 50 10 - b. 1( 0----0 QQ, 10 MOLU COHCEHTR ... TIOH OF IHHIBITOR Fig. 13. Elfect of metabolic inhibitors on K + accumulation and respiration, as in Fig. 12. In alI experiments, acetate was provided at 10 mM. (Courtesy of G. H. 5. AEBI (1953) compared a variety of lilammalian tissue slices in this type of experiment, and found the kidney by far the most active in accumulat- 39 Transport of Inorganic Cations Table VIII. ...
117414-71-8 - XNUBAOJRQSJYRM-XNIJJKJLSA-N - 3-O-(5-Fluoro-2,4-dinitrophenyl)ATP ether - Similar structures search, synonyms, formulas, resource links, and other chemical information.
S-(2,4-Dinitrophenyl)-Glutathione is a substrate for Glutathione-S-Transferase, that has a kinetically determined dissociation constant of 7μM.
We provide an alternative to dinitrophenols: green retarders and improved polymerization control technology for the styrene industry. | Ecolab
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In this paper the results of the influence of various metabolic inhibitors on dif- ferent periods of the vernalization process in winter wheat are provided. It was found that the initial period of vernalization is very sensitive to respiratory inhibitors such as azide and 2, 4-nitrophenol. In the middle period, the inhibitor of nucleo-acid metabolism such as 2-thiouracil significantly prolongated the process of vernalization. At the third period the protein metabolic inhibitor such as chloromycetin strongly inhibited the vernalization process. Our experiments demonstrated that a remarkable replacement of metabolic patterns is existed in the course of vernalization of winter wheat. The relative metabolic processes during the time of vernalization not only car- ried on different in rate and in action model of inhibitors but also alternatively. There- fore, we assumed that vernalization process of winter wheat may be divided into several periods (sub-processes) with different metabolic patterns. On the
The trends in the energy dependence of strong interaction characteristics that reveal themselves when an attempt is made to bring about a closer agreement between experimentally observed size dependence of several properties of high energy hadrons in air showers and the corresponding Monte Carlo simulations are discussed. The discussion shows the need for an increase in the inelasticity and interaction cross section of both pions and nucleons at ultra-high energies, as also an increase in the cross section for the production of nucleon-antinucleon pairs and also the need for postulating a process similar to the gammaization process of Nikolsky according to which a considerable fraction of energy is transferred to the soft component by-passing the normal pionization. ...
at Oregon State University Revised June 1996 Dinoseb Trade and Other Names: Product names for pesticides containing dinoseb include Basanite, Caldon, Chemox, Chemsect DNBP, Dinitro, Dynamyte, ... dinoseb exposure. This pesticide is not commercially available in the U.S. Dinoseb is a highly toxic compound. Prior to its ban, it was a Restricted Use Pesticide (RUP), and products containing dinoseb ...
Jeejeebhoy, H, Inactication of thymus and marrow-derived lymphocytes by heterologous antilymphocyte serum (als). (1971). Subject Strain Bibliography 1971. 1407 ...
Dinitrophenyl acetate | C8H6N2O6 | CID 90688786 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
1-Cyclooctylidene-2-(2,4-dinitrophenyl)hydrazine | C14H18N4O4 | CID 273883 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
(2,4-dinitrophenyl)-seryl-threonyl-alanyl-threonyl-lysyl-leucyl-seryl-tryptophan: substrate for lysine-specific metalloendopeptidases
What doesnt kill you makes you stronger, they say. But 2,4-Dinitrophenol, or DNP, might be the exception to the rule: it is apt to do both.. A spate of deaths in Britain in recent years has highlighted the dangers of a chemical used not just by bodybuilders but by slimmers too.. Continue reading…. This post was syndicated from Health , The Guardian. Click here to read the full text on the original website.. ...
VIII. Extensions: (these questions were borrowed from a cell biology text whose author I have forgotten - sorry). 1. Normally, oxidative phosphorylation is tightly coupled to electron transport. Or in other words, no electron flow through the ETC will occur unless ATP can be made. However, there are certain uncoupling agents that allow electron flow while preventing ATP synthesis. One such agent is 2,4-dinitrophenol (DNP) which is toxic to humans causing a marked increase in metabolism and temperature, sweating, collapse and death. For a brief period in the 1940�s, sublethal doses of DNP were actually prescribed as a means of weight reduction in humans ...
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1. In 33 obese patients, the arm-to-tongue circulation time was measured by the intravenous saccharin method. The average of the group was 13.3 seconds, essentially normal figures.. 2. In 14 of the group, dinitrophenol (1-2-4) was given, and further determinations of the circulation time made. In 7 patients an increase in blood velocity was noted, the average acceleration being 3.3 seconds per patient.. 3. Further studies are indicated to determine the manner in which such speeding up of the blood flow is brought about.. ...
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Molecular imprinted polymers (MIP) are considered one of the most promising selective and novel separation methods for removal phenolic compound in wastewater treatment. MIP are crosslinked polymeric materials that exhibit high binding capacity and selectivity towards a target molecule (template), purposely present during the synthesis process. In this work MIP were prepared in a bulk polymerization method in acetonitrile using 2,4-dinitrophenol, acrylamide, ethylene glycol dimethacrylate, and benzoyl peroxide as template, functional monomer, cross-linker and initiator, respectively. An adsorption process for removal of nitrophenol using the fabricated MIP was evaluated under various pH and time conditions. The parameters studied for 2,4-dinitrophenol includes adsorption kinetics, adsorption isotherm, and selectivity. The maximum adsorption of nitrophenol by the fabricated MIP was 3.50 mg/g. The adsorption of 2,4-dinitrophenol by the fabricated MIP was found effective at pH 6.0. A kinetics study showed
Mesenteric lymph node cells were obtained from rabbits that were primed with dinitrophenylated ragweed antigen (DNP-Rag) and supplemented with free Ascaris antigen (Asc); in vitro anti-hapten antibody response of the primed cells was studied. It was found that stimulation of Rag-sensitized cells with free Rag enhanced anti-DNP antibody response to DNP-unrelated carrier conjugate (DNP-KLH) but suppressed the response of the same cell suspension to DNP-Asc. It was also found that both IgG and IgE antibody responses to DNP-Rag were suppressed by the addition of free Asc with the homologous antigen. Mechanisms involved in the enhancement and suppression of antibody response by free carrier were explored with cell-free supernatant (CFS) obtained from the culture of primed lymph node cells with free carrier. The results showed that essentially all CFS preparations studied enhanced antibody response when they were added to primed lymph node cells which had been treated with a hapten-protein conjugate. ...
TY - JOUR. T1 - The energy dependence of proton-induced degradation in AlGaN/GaN high electron mobility transistors. AU - Hu, Xinwen. AU - Choi, Bo K.. AU - Barnaby, Hugh J.. AU - Fleetwood, Daniel M.. AU - Schrimpf, Ronald D.. AU - Lee, Sungchul. AU - Shojah-Ardalan, S.. AU - Wilkins, R.. AU - Mishra, Umesh K.. AU - Dettmer, Ross W.. PY - 2004/4/1. Y1 - 2004/4/1. N2 - The effects of proton irradiation at various energies are reported for AlGaN/GaN high electron mobility transistors (HEMTs). The devices exhibit little degradation when irradiated with 15-, 40-, and 105-MeV protons at fluences up to 1013 cm-2, and the damage completely recovers after annealing at room temperature. For 1.8-MeV proton irradiation, the drain saturation current decreases 10.6% and the maximum transconductance decreases 6.1% at a fluence of 1012 cm-2. The greater degradation measured at the lowest proton energy considered here is caused by the much larger nonionizing energy loss of the 1.8-MeV protons.. AB - The ...
King, D W.; Bock, F G.; and Moore, G E., Dinitrophenol inhibition of pituitary adenoma formation in mice fed propylthiouracil. (1963). Subject Strain Bibliography 1963. 586 ...
Multiple antibody components of rabbit antisera against p-azobenzenearsonate (Rp) were studied with respect to their globulin nature and skin-sensitizing activi
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The initial studies reporting on the fat-loss potential of DNP were all short-term, with none lasting more than three months. Those early researchers noted that they couldnt predict toxic effects with extended use. Sure enough, other studies began appearing that showed that DNP was hardly innocuous. A 1933 issue of the Journal of the American Medical Association told of a severe skin reaction in a woman who took DNP for two weeks. A 50-year-old Viennese doctor in San Francisco took an overdose of it for weight-loss purposes and cooked himself from the inside. After using a prior, lower dose of DNP without incident, he had opted for a dose that was beyond the suggested safe range. When told by another physician that he should avoid being so reckless again, the Viennese doctor said that he would take a higher dose, and if it killed him, he would just be another martyr to science. While he didnt exactly become a medical martyr, he did die an agonizing death ...
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Hapten: A small molecule that acts antigenic once it has been combined with carrier molecules (to form a hapten-carrier conjugate ...
Or, How I Learned to Stop Worrying and Love Sodium Azide. Never eat anything you cant pronounce. - Some sperg on an anti-vaccination, anti-...
Competitive immunoassay-validated anti-Hapten antibody against hapten [Salbutamol(SAL)] and hapten-carrier conjugates [BSA-Salbutamol(SAL)] competitive antigens(Carrier-coupled antigen, immunogen, hapten-carrier conjugates, BSA-conjugated, OVA-conjugated). The anti-Hapten antibody against hapten [Salbutamol(SAL)] had been validated with our hapten-carrier conjugates [BSA-Salbutamol(SAL)]via competitive ELISA test. GeneMedi offers paired anti-small molecules (Chemicals, Antibiotics, Mycotoxins, Hormones, Drugs of Abuse , etc.) antibodies (monoclonal antibody, mab)and small molecules competitive antigens (Carrier-coupled antigen, immunogen, hapten-carrier conjugates, BSA-conjugated , OVA-conjugated) for the rapid test and diagnostics kit of Growth Promoters, Toxic Heavy Metal, Myotoxins, Nutritions, Food Safety, Pesticides, Drugs of Abuse, Allergen, Antibiotics, Agricultural, Water Contamination and so on. All our anti-chemicals antibodies and small molecules hapten-carrier conjugates antigens (BSA
2,4-Dinitrophenol (2,4-DNP or simply DNP) is a natural compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline strong that has a sweet, moldy odor. It sublimes, is unpredictable with steam, and is soluble in a lot of natural solvents in addition to liquid alkaline services. When in a dry type, it is a high explosive and has an immediate rise threat. It is a precursor to other chemicals and is biochemically active, preventing adenosine triphosphate (ATP) production in cells with mitochondria.. Commercially, DNP is utilized as an antibacterial and as a non-selective bioaccumulating pesticide.. DNP is particularly advantageous as a herbicide together with other carefully associated dinitrophenol herbicides like 2,4-dinitro-o-cresol (DNOC), dinoseb and dinoterb. Given that 1998 DNP was withdrawn from agricultural usage. Currently, there are no actively registered pesticides including DNP in United States or Europe.. It is a chemical intermediate in the production of sulfur dyes, wood ...
Chicken 7S anti-DNP antibodies requiring a high concentration of salt for precipitation with antigen were purified by immunoadsorption. Difference spectra between free and antibody-bound ligand (ε-DNP-L-lysine) showed maxima at 392 and 470 nm. These maxima and the Δεm at 470 nm were essentially the same as encountered with mammalian and shark antibodies. Chicken anti-DNP antibody of the 7S class has two combining sites (180,000 daltons) as measured in equilibrium dialysis. The average intrinsic association constant (1.6 × 106 M-1 at 5°C) was not altered by wide variation in salt concentration. The 5S bivalent fragment obtained by pepsin digestion also required the anomalous high salt concentration for immune precipitation.. ...
In order to reduce annoying reflection of ambient light, anti-glare film has been developed and applied to electronic displays, such as PCs and smartphones.. However, as a side-effect of applying anti-glare film, sparkle pattern becomes obvious as fine and irregular luminance distribution caused by the combination of uneven surface-structure of anti-glare film and display matrix structure.. In the past, the degree of sparkle was evaluated visually by skilled personnel based on professional experience, but individual differences affected the reproducibility of the results. Furthermore, there was another problem regarding how to quantify the measurement results.. This led to a series of developments in the market of quantitative sparkle measurement methods, i.e. measurement of display sparkle contrast.. However, even with the same sample, it has been difficult to get reliable and quantitatively comparable data from different parties. This is largely because the measurement parameters from each ...
Please contact us for quicker reply: Skype: liu.sarah6 & Whatsapp: 008613809892441 Product Name: DNP (2,4-Dinitrophenylhydrazine) CAS No.: 119-26-6 MF: C6H6N4O4 Synonyms: (2
Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2- ...
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Positronium (Ps)-He scattering presents one of the few opportunities for both theory and experiment to tackle the fundamental interactions of Ps with ordinary matter. Below the dissociation energy of 6.8 eV, experimental and theoretical work has struggled to find agreement on the strength of this interaction as measured by the momentum-transfer cross section (Ïm). Here, we present work utilizing the Doppler broadening technique with an age-momentum correlation apparatus. This work demonstrates a strong energy dependence for this cross section at energies below 1 eV and is consistent with previous experimental results.
73296-91-0 - Phenol, 4-((2,4-dinitrophenyl)amino)-, reaction products with sodium sulfide (Na2(Sx)), oxidized - Searchable synonyms, formulas, resource links, and other chemical information.
One of the first anti-obesity therapies to be introduced and marketed as a pharmaceutical was 2-4-Dinitrophenol, which entered the market around 1934.
The TOP Server DNP 3.0 Protocol OPC Server from Software Toolbox talks to intelligent pump controllers scattered across a large site that deploys the Distributed Network Protocol (DNP) for wireless, exception-based communication.
Nma-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DNP)-D-Arg-D-Arg-NH2 3229-v 1 mg | 135.00 EUR[2- (Methylamino)benzoyl]- L- isoleucyl- L- ...
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DNP-β-alanine; CAS Number: 3185-97-5; Synonym: N-(2,4-Dinitrophenyl)-β-alanine; Linear Formula: C9H9N3O6; find Sigma-Aldrich-D7129 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.