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Define dimenhydrinate. dimenhydrinate synonyms, dimenhydrinate pronunciation, dimenhydrinate translation, English dictionary definition of dimenhydrinate. n. A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness. n a white slightly soluble bitter-tasting...
Dimenhydrinate, also known as Dramamine or Gravol, is an over-the-counter drug used to prevent nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate is a combination drug composed of DB01075 and DB14132 in a salt form, with 53%-55.5% of diphenhydramine, and not less than 44%-47% of 8-chlorotheophylline, calculated on the dried basis. The antiemetic properties of dimenhydrinate are primarily thought to be produced by diphenhydramines antagonism of H1 histamine receptors in the vestibular system while the excitatory effects are thought to be produced by 8-chlorotheophyllines adenosine receptor blockade . The addition of 8-chlorotheophylline was initially intended to counteract the sedative effects of diphenhydramine. When used in large doses, dimenhydrinate has been shown to cause a high characterized by hallucinations, excitement, incoordination, and disorientation .
DIMENHYDRINATE (injection, solution) comes in different strengths and amounts. The appearance of Dimenhydrinate can differ based on the dosing.
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Vintage SEARLE Package of DRAMAMINE Tablets from Mexico exp 1952. Vintage 1950s McKesson Pumice Jar Nearly Full by CapricornOneEphemera, $5.00. 523-87-5 Trade Name Manufacturer Country Year Introduced Dramamine Searle US 1949 Dramamine Searle France 1957 Dramocen Central US 1977 Dimate. Albert L. Raymond, 87, a biochemist, was senior vice president and director of research for G.D. Searle & Co. when it developed dramamine. G.D. Searle, LLC is a wholly owned trademark of Pfizer. It is currently used mainly as a It is also known for its release of the first bulk laxative, Metamucil, in 1934; Dramamine, for motion sickness; the COX-2 inhibitors Celebrex and Bextra.. Each 5 mL DRAMAMINE Liquid contains 15,6 mg dimenhydrinate and 5 8.7 mm in diameter, scored on one side and "Searle"above 72 stamped on the other. Originally marketed by G.. D. Searle in 1949, Dramamine was sold to Procter & Gamble in 1985, and was in turn sold to Upjohn in 1991, and to. ...
Dimenhydrinate is generally used to prevent nausea and vomiting caused by motion sickness in dogs and cats. This medication may be used for other conditions as determined by your veterinarian.
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Dramamine affects certain receptors in central nervous system to treat dizziness, nausea, vomiting caused by sea and air sickness.
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noun antihistamine and antiemetic (trade name Dramamine) used to treat motion sickness • Syn: ↑Dramamine • Usage Domain: ↑trade name (for: ↑Dramamine) • Hypernyms: ↑antihistamine, ↑
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Abdominal blockage of iliohypogastric and ilio-inguinal nerves for management of post-caesarean pain: A novel method. Boztosun, Abdullah; Duger, Cevdet; Kosar, Mehmet Ilkay; Salk, Ismail; Gursoy, Sinan; Muderris, Iptisam Ipek; Yanik, Ali // South African Journal of Obstetrics & Gynaecology;Jan2012, Vol. 18 Issue 1, p23 Objective. The aim of this study was to compare pain relief after caesarean section achieved by an intra-abdominal iliohypogastric and ilio-inguinal (IHII) nerve block with levobupivacaine with that in patients given a placebo. Study design. A total of 60 healthy women scheduled for caesarean... ...
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ABSTRACT Objective: Efficacy and tolerability of the fixed combination cinnarizine 20mg/dimenhydrinate 40mg was compared to cinnarizine 50mg and dimenhydrinate 100mg in peripheral, central or mixed peripheral/central vertigo. Methods: 189 patients were randomized to receive 1 tablet of medication, 3 times daily, for 4 weeks. Vertigo (mean vertigo score, MVS) and concomitant symptoms, balance (craniocorpography) and […]. ...
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Finding an increased risk of dementia and Alzheimers with so many common over-the-counter medications such as Benadryl and Chlortrimeton (the first generation allergy drug that so many people took for years) was an unpleasant surprise. Note: they found the link with high doses or heavy use (3 or more years). Some examples of common anticholinergics (from Wikipedia) are: atropine, benztropine (Cogentin), chlorpheniramine (Chlor-Trimeton), dimenhydrinate (Dramamine), diphenhydramine (Benadryl, Sominex, Advil PM, etc.), doxylamine (Unisom), hydroxyzine (Atarax, Vistaril), ipratropium (Atrovent), oxybutynin (Ditropan, Driptane, Lyrinel XL), tolterodine (Detrol, Detrusitol), tiotropium (Spiriva), and bupropion (Zyban, Wellbutrin). The message here: only take medications when absolutely needed and for as little a time as necessary. The study was done on older adults, so now the question is: what about children or young adults who take these drugs for years? Is there a similar increased risk later in ...
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1. Borison HL, Wang SC. Physiology and pharmacology of vomiting. Pharmacol Rev 1953; 5:193-230. 2. Alvarez WC. Reverse peristalsis in the bowel, a precursor of vomiting. JAMA 1925; 85:1051-1054. 3. Borison HL, Wang SC. Further Studies on the Vomiting Center. Federation Proceedings 1950; 9:14-15. 4. Goldberg SL. The afferent paths of nerves involved in the vomiting reflex induced by distension of the isolated pyloric pouch. Am J Physiol 1931; 99:156- 5. Borison HL. Area postrema - chemoreceptor circumventricular organ of the medulla-oblongata. Prog Neurobiol 1989; 32:351-390. 6. Henzi I, Walder B, Tramèr MR. Metoclopramide in the prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized, placebo-controlled studies. Br J Anaesth 1999; 83:761-771. 7. Kranke P, Morin AM, Roewer N, Eberhart LH. Dimenhydrinate for prophylaxis of postoperative nausea and vomiting: a meta-analysis of randomized controlled trials. Acta Anaesthesiol Scand 2002; 46:238-44. 8. ...
ANTIEMETICS are used to prevent vomiting. They are thus related to antinauseant drugs which are used to reduce or prevent the feeling of nausea that very often precedes the physical process of vomiting (emesis). Commonly, the terms are used synonymously, though it is usually an antinauseant action that is being sought. The type of antinauseant drugs used, and the likelihood of success, depends on the mechanism and origin of the nauseous sensation, and there are a number of ways it can be triggered. Motion sickness (travel sickness) can often be prevented by taking antinauseant drugs before travelling, e.g. the antihistamines meclozine and dimenhydrinate, and the anticholinergic hyoscine. Probably all these drugs act as central MUSCARINIC CHOLINOCEPTOR ANTAGONISTS. Similar drugs may be used to treat nausea and some other symptoms of labyrinthine disease (where the vestibular balance mechanisms of the inner ear are disturbed, e.g. in Menieres disease), though other antinauseant drugs may also be ...
Dimenhydrinate belongs to a group of medications called antiemetics. This medication is used to prevent and treat motion sickness as well as nausea and vomiting associated with various conditions such as chemotherapy, radiation, and surgery. It is also used to treat nausea and spinning sensations (vertigo) due to M ni res disease and other conditions that cause these symptoms.
Anti-Nausee: Dimenhydrinate belongs to a group of medications called antiemetics. This medication is used to prevent and treat motion sickness as well as nausea and vomiting associated with various conditions such as chemotherapy, radiation, and surgery. It is also used to treat nausea and spinning sensations (vertigo) due to Ménières disease and other conditions that cause these symptoms.
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