6-methoxy-1,5-dihydrobenzo[cd]indol-4(3H)-one - chemical structural formula, chemical names, chemical properties, synthesis references
Stereoselective metabolism of dibenzo[a,l]pyrene (DB[a,l]P), 2-chlorodibenzo[a,l]pyrene (2-Cl-DB[a,l]P) and 10-chlorodibenzo[a,l]pyrene (10-Cl-DB[a,l]P) by rat liver microsomes was studied and effects of the chloro substituent on the metabolism were determined. All three compounds produced trans-8,9-dihydrodiol, trans-11,12-dihydrodiol, and the 7-hydroxyl derivative as major metabolic products and several other phenolic derivatives as minor metabolites. The trans-8,9- and 11,12-dihydrodiols of DB[a,l]P and 2-Cl-DB[a,l]P preferentially adopted a quasidiequatorial conformation, whereas 10-Cl-DB[a,l]P trans-8,9- and 11,12-dihydrodiols preferentially adopted a quasidiaxial conformation. The yields of the trans-11,12-dihydrodiol metabolites are: DB[a,l]P trans-11,12-dihydrodiol | 2-Cl-DB[a,l]P trans-11,12-dihydrodiol || 10-Cl-DB[a,l]P trans-11,12-dihydrodiol. Circular dichroism (CD) spectral analysis indicates that the trans-8,9-dihydrodiol and trans-11,12-dihydrodiol metabolites from DB[a,l]P, 2-Cl-DB[a,l]P
The effect of ellagic-acid (476664) on in-vitro metabolism of benzo(a)pyrene (50328) (BaP) or trans-7,8-dihydro-7,8- dihydroxybenzo(a)pyrene (trans BaP) by mouse lung explants was investigated. Explants were cultured for 16 hours in the presence or absence of 10 to 100 micromolar (microM) concentrations of the naturally occuring plant phenol. Ellagic-acid was then removed and explants were incubat
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008 ...
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(Ref. BAP-2017-336) Occupation : Full-time Period : Fixed-term contract extendable Place : Leuven Apply no later than : June 26, 2017 In the past decade, psychology ...
70133-84-5 - JZLWANHLFXZFCU-UHFFFAOYSA-N - 2-Chloro-12-(2-piperidinoethyl)dibenzo(d,g)-1,3,6-dioxazocine - Similar structures search, synonyms, formulas, resource links, and other chemical information.
CAS NO:192-97-2; Chemical name:benzo[e]pyrene ; physical and chemical property of 192-97-2, benzo[e]pyrene is provided by ChemNet.com
C043931000 - Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA - Searchable synonyms, formulas, resource links, and other chemical information.
N,N-Diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide/ACM53257026 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Creative-Proteomics offer cas 192-65-4 DIBENZO[A,E]PYRENE UNLABELED. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
There are 16 genes that encode full-length UGT proteins (Mackenzie, 1995; Tukey and Strassburg, 2000). Eight are encoded by theUGT1A locus (1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10) (Ritter et al., 1992; Gong et al., 2001) and eight are encoded byUGT2 genes (2A1, 2B4, 2B7,2B10, 2B11, 2B15, 2B17, and2B28). Gagne et al. (2002) demonstrate that stable expression of the majority of these gene products in tissue culture confirm that UGT1A1, UGT1A7, and UGT1A9 were the most efficient in glucuronidating SN-38, a finding that supports previous observations (Iyer et al., 1998; Ciotti et al., 1999). What distinguishes the work published by Gagné et al. (2002) in this issue of Molecular Pharmacology from previous reports is the important addition of expression experiments carried out with allelic variants of these UGTs. The authors carefully compare the catalytic efficiencies of expressed UGTs and conclude that selective allelic variants associated withUGT1A1 and UGT1A7 have a significant impact on the ...
Structure, properties, spectra, suppliers and links for: 2-[4-(4-Chlorophenyl)cyclohexylidene]-3,4-dihydroxy-1(2H)-naphthalenone.
அசிட்டோனைடு என்பது கரிம வேதியியலில், அசிட்டோன் மற்றும் டையால் -ன் வளைய கீட்டைல் அமைப்பு சேர்ந்து உருவான ஒரு வினைசெயல் தொகுதி. இந்த அமைப்பிற்கான திட்டமிடப்பட்ட பெயர் ஐசோபுரபைலிடீன் கீடைல் ஆகும். இது 1,2- மற்றும் 1,3-diols[1] க்கு மிகவும் பொதுவான பாதுகாக்கும் தொகுதி.கீட்டைல் தொகுதியை நீர்த்த அமிலங்களைக் கொண்டு நீராற்பகுக்கும் போது பாதுகாப்பு தொகுதியை[2] நீக்க முடியும்.. ...
2,3-Dihydrobenzo[b]furan-7-carboxylic acid, 97%, Maybridge Amber Glass Bottle; 250mg 2,3-Dihydrobenzo[b]furan-7-carboxylic acid, 97%, Maybridge Dihep to Dihydrow...
1-Methyl-4-[3-[(2-methyltetrazol-5-yl)methyl]-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine | C22H26N6S | CID 49781890 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
879 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants implicated in the causation of human lung cancer. One pathway of metabolic activation that yields reactive oxygen species (ROS) involves the oxidation of PAH trans-dihydrodiols by aldo-keto reductases (AKRs) to yield reactive and redox-active o-quinones, which can cause oxidative DNA damage (e.g. 8-oxo-dGuo). Evidence for this pathway in lung cells has been hampered by the difficulty in detecting 8-oxo-dGuo levels reliably in intact cells. We used the single cell gel electrophoresis (Comet) assay to detect DNA strand breaks in human lung adenocarcinoma (A549) cells (which express AKR1A1 and AKR1C isoforms) following treatment with BP-7,8-diol (AKR substrate), and BP-7,8-dione (AKR-product) and (+)-anti-BPDE. In the presence of DNA synthesis inhibitors (cytosine arabinoside and hydroxyurea) all three PAH metabolites produced significant DNA strand breaks in a concentration-dependent manner. Inclusion of ROS scavengers ...
Benzo[a]pyrene (BP) 7,8-dihydrodiol is metabolized by the rat liver monooxygenase system to diastereomeric benzo[a]pyrene 7,8-diol 9,10-epoxides that are highly reactive, toxic, and mutagenic. One of the isomers of these diol epoxides is highly carcinogenic to newborn mice. Oxidative metabolism of (-)-benzo[a]pyrene 9,10-dihydrodiol has been investigated to see whether 9,10-diol 7,8-epoxides are formed in analogy to the metabolism of BP 7,8-dihydrodiol, and mutagenic activities of synthetic BP 9,10-diol 7,8-epoxides have been evaluated. Unlike BP 7,8-dihydrodiol, the (-)-9,10-dihydrodiol is metabolized primarily to a phenolic derivative rather than a diol epoxide. Chemical and spectral studies established that the phenolic hydroxyl group had been introduced at either position 1 or 3 of the 9,10-dihydrodiol. Weak inherent mutagenic activity of the synthetic 9,10-diol 7,8-epoxides and the very low degree of their metabolic formation explains why metabolic activation of BP 9,10-dihydrodiol in the ...
You are viewing an interactive 3D depiction of the molecule 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-amine (C30H14N5O9P) from the PQR.
Dibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS report, Dibenzo[b,e]Thiepin-11(6H)-One MSDS safety technical specifications search, Dibenzo[b,e]Thiepin-11(6H)-One safety information specifications ect.
Zaleski, J; Bansal, S K.; and Gessner, T, "Formation of glucuronide, sulphate and glutathione conjugates of benzo[a]pyrene metabolites in hepatocytes isolated from inbred strains of mice." (1983). Subject Strain Bibliography 1983. 1888 ...
Ābele E.; Golomba L.; Beresņeva T.; Višņevska J.; Jaschenko E.; Shestakova I.; Gulbe A.; Grinberga S.; Belyakov S.; Abele R. A new pathway for the preparation of biologically active 2-substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines and related compounds by palladium-catalyzed cyclization of amidoximes with o-iodobenzyl bromide or 2-bromo-3-chloromethylpyridine. Arkivoc 2012, 2012(8), 49-61 ...
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Diol Die stationäre Phase Eurospher 100 Diol kann vielseitig für unterschiedliche polare Modi (NP, RP und IC) eingesetzt werden. Das Eurospher Kieselgel ist durch ein Dihydroxypropylreagenz modifiziert. Im Vergleich zum Packungsmaterial Eurospher Si ist es unpolarer und weist geringere Equilibrierungszeiten auf Die Stärke von Eurospher 100 Diol ist durch Bestimmungen von Tetracyclinen oder nichtionischen Tensiden bewiesen ...
5,20-dihydroxy-6,7-epoxy-1-oxo-5-witha-2,24-dienolide: has immunomodulating properties; RN given refers to (5alpha,6alpha,7alpha,22R)-isomer
هدف: اسینتوباکتر بومانی یکی از پاتوژن‏های اصلی بیمارستانی است و ظرفیت بالایی برای مقاومت به انواع مواد ضد میکروبی موجود دارد. اسینتوباکتر بومانی انواع متفاوتی از عفونت‏ها شامل پنومونی، مننژیت و عفونت‏های مرتبط با خون را ایجاد می‏کند. پروتئین‏های مربوط به بیوفیلم (Bap) پروتئینی اختصاصی در سطح سلول است که مستقیماً در تشکیل بیوفیلم در اسینتوباکتر بومانی مورد نیاز است و نقش اصلی را در عفونت‏زایی باکتری بازی می‏کند. در مطالعه قبلی محققان حاضر نواحی متعددی از این پروتئین بررسی شد و با در نظر گرفتن معیارهای مختلف، چند ناحیه به عنوان نواحی حفاظت شده و ایمنی
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TY - JOUR. T1 - Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin. AU - Kootstra, A.. AU - Slaga, T. J.. PY - 1980/4/14. Y1 - 1980/4/14. N2 - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. AB - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. UR - ...
1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4-piperidine]-2-one 89419-40-9 NMR spectrum, 1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4-piperidine]-2-one H-NMR spectral analysis, 1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4-piperidine]-2-one C-NMR spectral analysis ect.
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).
Phosphorus › (R)-3-(tert-Butyl)-4-(3,5-diisopropyl-2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole, 97% (,99% ee) ...
Phosphorus › (R)-3-(tert-Butyl)-4-(4,6-dimethoxy-[1,1:3,1-terphenyl]-5-yl)-2,3-dihydrobenzo[d][1,3]oxaphosphole, 97% (,99% ee) ...
J Med Chem. 2010 Sep 9;53(17):6386-97.Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 21248-00-0(6-BROMOBENZO(a)PYRENE),please inquire us for 21248-00-0(6-BROMOBENZO(a)PYRENE).
3beta,5-dihydroxy-1-N-methyl-indoline-2beta-carbonyl amino-D-alanyl-erythro-beta-hydoxyisoleucinyl-glycine: indolinepeptide from Paecilomyces sp. J300; structure in first source
A series of 2,3-dihydrobenzo[b]selenophene-5-ol antioxidants was prepared by subjecting suitably substituted allyl 4-methoxyphenyl selenides to microwave-induced seleno-Claisen rearrangement/intramolecular Markovnikov hydroselenation followed by boron tribromide-induced O-demethylation. The novel antioxidants were assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system containing N-acetylcysteine as a thiol reducing agent in the aqueous phase. Antioxidant efficiency as determined by the inhibited rate of peroxidation, Rinh, increased with increasing methyl substitution (Rinh = 46−26 μM/h), but none of the compounds could match α-tocopherol (Rinh = 22 μM/h). Regenerability as determined by the inhibition time, Tinh, in the presence of the thiol regenerating agent decreased with increasing methyl substitution. Thus, under conditions where the unsubstituted compound 5a inhibited peroxidation for more than 320 min, ...
An enzyme immunoassay for the detection of benzo[a]pyrene covalently conjugated to macromolecules has been developed. The monoclonal antibody, raised through in vitro immunization reacted with benzo[a]pyrene metabolites bound to DNA, RNA and proteins. The lower detection limit for the assay was 1 pmol for benzo[a]pyrene bound to DNA or RNA, and 5 pmol when bound to protein.
EINECS (European INventory of Existing Commercial chemical Substances) as published in O.J. C 146A, 15.6.1990. EINECS is an inventory of substances that were deemed to be on the European Community market between 1 January 1971 and 18 September 1981. EINECS was drawn up by the European Commission in the application of Article 13 of Directive 67/548/EEC, as amended by Directive 79/831/EEC, and in accordance with the detailed provisions of Commission Decision 81/437/EEC. Substances listed in EINECS are considered phase-in substances under the REACH Regulation ...
... Systematic (IUPAC) name 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine Identifiers CAS number 50-49-7 ATC code
Synonyms for Geminal diol in Free Thesaurus. Antonyms for Geminal diol. 2 synonyms for diol: dihydric alcohol, glycol. What are synonyms for Geminal diol?
Quetiapine EP Impurity C ;. 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl 2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)acetate ;. CAS # 1798840-31-9 ;. C40H42N6O3S2 ;. MW: 718.93. ...
LiChrosorb Diol LiChrosorb ist eine der erfolgreichsten und zuverlässigsten Packungsmaterialien der letzten 25 Jahre, was in der Literatur in Form von tausenden Applikationen gut dokumentiert ist. Die total porösen irregulären Partikel werden letztendlich in 5-, 7- und 10 µm - Fraktionen klassifiziert. Die Familie der LiChrosorb-Packungsmaterialien umfasst den Bereich der nichtpolaren (RP2, RP8, RP18, RP select B), polaren (Si 60, Si 100) und mittelpolaren Derivate (NH2 , CN, Diol ...
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Two diol-epoxide metabolites of benzo[c]phenanthrene and benzo[a]pyrene, polynuclear aromatic hydrocarbons which occur in the environment, were tested for carcinogenicity by direct injection into the mammary fat pads of female CD rats. The compounds anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene (BcPDE), a fjord region diol-epoxide, and anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a bay region diol-epoxide, were applied at total doses of 12.2 µmol. 6-Nitrochrysene was applied at the same dose as a positive control (K. El-Bayoumy, A. Rivenson, P. Upadhyaya, Y-H. Chae, and S. S. Hecht, Cancer Res. 53: 3719-3722, 1993). The sterically hindered fjord region diol-epoxide BcPDE was a powerful mammary tumorigen and carcinogen, rapidly inducing significantly more fibroadenoma and adenocarcinoma than either of the other compounds. Anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene was a weaker mammary tumorigen than BcPDE and 6-nitrochrysene. The ...
PAHs are the reactive toxic chemical compounds which are present as environmental pollutants. These reactive compounds not only diffuse through the membranes of the cell but also partition into the membranes. They react with the DNA of the cell giving rise to toxicity and may cause cancer. To understand the cellular behavior of these foreign compounds, a mathematical model including the reaction-diffusion system and partitioning phenomenon has been developed. In order to reduce the complex structure of the cytoplasm due to the presence of many thin membranes, and to make the model less computationally expensive and numerically treatable, homogenization techniques have been used. The resulting complex system of PDEs generated from the model is implemented in Comsol Multiphysics. The numerical results obtained from the model show a nice agreement with the in vitro cell experimental results. Then the model was reduced to a system of ODEs, a compartment model (CM). The quantitative analysis of the ...
The environmental procarcinogen which are responcible for carcinogenesis, to form the proximate carcinogen, they require metabolic activation by drug metabolizing enzymes. The CYP3A subfamily enzymes play an important role in elimination of drugs. The substrates for CYP3A4 enzyme include drugs, and endogenous substances. Therefore, allelic changes in the coding regions ...
In vitro benzo[a]pyrene diol epoxide (BPDE)-induced DNA adducts in cultured peripheral lymphocytes have been shown to be a phenotypic biomarker of individuals DNA repair phenotype that is associated with cancer risk. In ...
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dibenzo[b,d]furan-2-carbaldehyde | C13H8O2 | CID 220843 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.