6-methoxy-1,5-dihydrobenzo[cd]indol-4(3H)-one - chemical structural formula, chemical names, chemical properties, synthesis references

Stereoselective metabolism of dibenzo[a,l]pyrene (DB[a,l]P), 2-chlorodibenzo[a,l]pyrene (2-Cl-DB[a,l]P) and 10-chlorodibenzo[a,l]pyrene (10-Cl-DB[a,l]P) by rat liver microsomes was studied and effects of the chloro substituent on the metabolism were determined. All three compounds produced trans-8,9-dihydrodiol, trans-11,12-dihydrodiol, and the 7-hydroxyl derivative as major metabolic products and several other phenolic derivatives as minor metabolites. The trans-8,9- and 11,12-dihydrodiols of DB[a,l]P and 2-Cl-DB[a,l]P preferentially adopted a quasidiequatorial conformation, whereas 10-Cl-DB[a,l]P trans-8,9- and 11,12-dihydrodiols preferentially adopted a quasidiaxial conformation. The yields of the trans-11,12-dihydrodiol metabolites are: DB[a,l]P trans-11,12-dihydrodiol | 2-Cl-DB[a,l]P trans-11,12-dihydrodiol || 10-Cl-DB[a,l]P trans-11,12-dihydrodiol. Circular dichroism (CD) spectral analysis indicates that the trans-8,9-dihydrodiol and trans-11,12-dihydrodiol metabolites from DB[a,l]P, 2-Cl-DB[a,l]P

The effect of ellagic-acid (476664) on in-vitro metabolism of benzo(a)pyrene (50328) (BaP) or trans-7,8-dihydro-7,8- dihydroxybenzo(a)pyrene (trans BaP) by mouse lung explants was investigated. Explants were cultured for 16 hours in the presence or absence of 10 to 100 micromolar (microM) concentrations of the naturally occuring plant phenol. Ellagic-acid was then removed and explants were incubat

This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008 ...

Unless indicated otherwise, all products are For Research Use Only and not for diagnostic or therapeutic use. Not for resale or transfer either as a stand-alone product or as a component of another product without written consent of EXBIO. EXBIO will not be held responsible for patent infringement or other violations that may occur with the use of our products. All orders are accepted subject to EXBIO s term and conditions which are available at www.exbio.cz ...

(Ref. BAP-2017-336) Occupation : Full-time Period : Fixed-term contract extendable Place : Leuven Apply no later than : June 26, 2017 In the past decade, psychology ...

70133-84-5 - JZLWANHLFXZFCU-UHFFFAOYSA-N - 2-Chloro-12-(2-piperidinoethyl)dibenzo(d,g)-1,3,6-dioxazocine - Similar structures search, synonyms, formulas, resource links, and other chemical information.

Structure, properties, spectra, suppliers and links for: (3R)-5,7-Dihydroxy-4H,6H-spiro[chromene-3,5-cyclobuta[f][1,3]benzodioxol]-4-one.

CAS NO:192-97-2; Chemical name:benzo[e]pyrene ; physical and chemical property of 192-97-2, benzo[e]pyrene is provided by ChemNet.com

Clinivex is a high quality reference standard supplier of Benzo[e]pyrene, CAS no - 192-97-2. View more information regarding Benzo[e]pyrene, including solubility, MSDS & more.

C043931000 - Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA - Searchable synonyms, formulas, resource links, and other chemical information.

N,N-Diethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide/ACM53257026 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.

Creative-Proteomics offer cas 192-65-4 DIBENZO[A,E]PYRENE UNLABELED. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.

There are 16 genes that encode full-length UGT proteins (Mackenzie, 1995; Tukey and Strassburg, 2000). Eight are encoded by theUGT1A locus (1A1, 1A3, 1A4, 1A6, 1A7, 1A8, 1A9, 1A10) (Ritter et al., 1992; Gong et al., 2001) and eight are encoded byUGT2 genes (2A1, 2B4, 2B7,2B10, 2B11, 2B15, 2B17, and2B28). Gagne et al. (2002) demonstrate that stable expression of the majority of these gene products in tissue culture confirm that UGT1A1, UGT1A7, and UGT1A9 were the most efficient in glucuronidating SN-38, a finding that supports previous observations (Iyer et al., 1998; Ciotti et al., 1999). What distinguishes the work published by Gagné et al. (2002) in this issue of Molecular Pharmacology from previous reports is the important addition of expression experiments carried out with allelic variants of these UGTs. The authors carefully compare the catalytic efficiencies of expressed UGTs and conclude that selective allelic variants associated withUGT1A1 and UGT1A7 have a significant impact on the ...

Structure, properties, spectra, suppliers and links for: 2-[4-(4-Chlorophenyl)cyclohexylidene]-3,4-dihydroxy-1(2H)-naphthalenone.

அசிட்டோனைடு என்பது கரிம வேதியியலில், அசிட்டோன் மற்றும் டையால் -ன் வளைய கீட்டைல் அமைப்பு சேர்ந்து உருவான ஒரு வினைசெயல் தொகுதி. இந்த அமைப்பிற்கான திட்டமிடப்பட்ட பெயர் ஐசோபுரபைலிடீன் கீடைல் ஆகும். இது 1,2- மற்றும் 1,3-diols[1] க்கு மிகவும் பொதுவான பாதுகாக்கும் தொகுதி.கீட்டைல் தொகுதியை நீர்த்த அமிலங்களைக் கொண்டு நீராற்பகுக்கும் போது பாதுகாப்பு தொகுதியை[2] நீக்க முடியும்.. ...

2,3-Dihydrobenzo[b]furan-7-carboxylic acid, 97%, Maybridge Amber Glass Bottle; 250mg 2,3-Dihydrobenzo[b]furan-7-carboxylic acid, 97%, Maybridge Dihep to Dihydrow...

1-Methyl-4-[3-[(2-methyltetrazol-5-yl)methyl]-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine | C22H26N6S | CID 49781890 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

879 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants implicated in the causation of human lung cancer. One pathway of metabolic activation that yields reactive oxygen species (ROS) involves the oxidation of PAH trans-dihydrodiols by aldo-keto reductases (AKRs) to yield reactive and redox-active o-quinones, which can cause oxidative DNA damage (e.g. 8-oxo-dGuo). Evidence for this pathway in lung cells has been hampered by the difficulty in detecting 8-oxo-dGuo levels reliably in intact cells. We used the single cell gel electrophoresis (Comet) assay to detect DNA strand breaks in human lung adenocarcinoma (A549) cells (which express AKR1A1 and AKR1C isoforms) following treatment with BP-7,8-diol (AKR substrate), and BP-7,8-dione (AKR-product) and (+)-anti-BPDE. In the presence of DNA synthesis inhibitors (cytosine arabinoside and hydroxyurea) all three PAH metabolites produced significant DNA strand breaks in a concentration-dependent manner. Inclusion of ROS scavengers ...

Benzo[a]pyrene (BP) 7,8-dihydrodiol is metabolized by the rat liver monooxygenase system to diastereomeric benzo[a]pyrene 7,8-diol 9,10-epoxides that are highly reactive, toxic, and mutagenic. One of the isomers of these diol epoxides is highly carcinogenic to newborn mice. Oxidative metabolism of (-)-benzo[a]pyrene 9,10-dihydrodiol has been investigated to see whether 9,10-diol 7,8-epoxides are formed in analogy to the metabolism of BP 7,8-dihydrodiol, and mutagenic activities of synthetic BP 9,10-diol 7,8-epoxides have been evaluated. Unlike BP 7,8-dihydrodiol, the (-)-9,10-dihydrodiol is metabolized primarily to a phenolic derivative rather than a diol epoxide. Chemical and spectral studies established that the phenolic hydroxyl group had been introduced at either position 1 or 3 of the 9,10-dihydrodiol. Weak inherent mutagenic activity of the synthetic 9,10-diol 7,8-epoxides and the very low degree of their metabolic formation explains why metabolic activation of BP 9,10-dihydrodiol in the ...

You are viewing an interactive 3D depiction of the molecule 9-(2-deoxy-5-o-phosphonopentofuranosyl)-n-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo[pqr]tetraphen-10-yl)-9h-purin-6-amine (C30H14N5O9P) from the PQR.

INTRODUCTION:Cancer is one of the non-communicable diseases and a public health problem in the world. Cancer is a second major cause of death in the world.. More than 70% of all death due to cancer occurred in developing countries. One of main types of cancer is breast cancer in the world 1.. The role of interactions between genes and environment in carcinogenesis is clearly demonstrated by phase I and II enzymes that constitute the central armamentarium against toxic chemicals and carcinogens. Several environmental carcinogens that are not chemically active undergo metabolic activation.. Cytochrome P450, a family of phase I hemoproteins, represents a major adaptive response against chemical challenge from the environment and catalyzes the activation of various procarcinogens to ultimate carcinogens. The ultimate carcinogens in turn interact with DNA, resulting in chromosomal abnormalities and mutation 1 is in key growth regulatory genes that eventually culminate in neoplastic transformation. ...

Dibenzo[b,e]Thiepin-11(6H)-One 1531-77-7 MSDS report, Dibenzo[b,e]Thiepin-11(6H)-One MSDS safety technical specifications search, Dibenzo[b,e]Thiepin-11(6H)-One safety information specifications ect.

Zaleski, J; Bansal, S K.; and Gessner, T, Formation of glucuronide, sulphate and glutathione conjugates of benzo[a]pyrene metabolites in hepatocytes isolated from inbred strains of mice. (1983). Subject Strain Bibliography 1983. 1888 ...

Ābele E.; Golomba L.; Beresņeva T.; Višņevska J.; Jaschenko E.; Shestakova I.; Gulbe A.; Grinberga S.; Belyakov S.; Abele R. A new pathway for the preparation of biologically active 2-substituted 1,5-dihydrobenzo[e][1,2,4]oxadiazepines and related compounds by palladium-catalyzed cyclization of amidoximes with o-iodobenzyl bromide or 2-bromo-3-chloromethylpyridine. Arkivoc 2012, 2012(8), 49-61 ...

EPL has expertise in the evaluation of respiratory tract tissues in animals exposed to chemicals and compounds via inhalation & other routes of exposure.

Diol Die stationäre Phase Eurospher 100 Diol kann vielseitig für unterschiedliche polare Modi (NP, RP und IC) eingesetzt werden. Das Eurospher Kieselgel ist durch ein Dihydroxypropylreagenz modifiziert. Im Vergleich zum Packungsmaterial Eurospher Si ist es unpolarer und weist geringere Equilibrierungszeiten auf Die Stärke von Eurospher 100 Diol ist durch Bestimmungen von Tetracyclinen oder nichtionischen Tensiden bewiesen ...

5,20-dihydroxy-6,7-epoxy-1-oxo-5-witha-2,24-dienolide: has immunomodulating properties; RN given refers to (5alpha,6alpha,7alpha,22R)-isomer

هدف: اسینتوباکتر بومانی یکی از پاتوژن‏های اصلی بیمارستانی است و ظرفیت بالایی برای مقاومت به انواع مواد ضد میکروبی موجود دارد. اسینتوباکتر بومانی انواع متفاوتی از عفونت‏ها شامل پنومونی، مننژیت و عفونت‏های مرتبط با خون را ایجاد می‏کند. پروتئین‏های مربوط به بیوفیلم (Bap) پروتئینی اختصاصی در سطح سلول است که مستقیماً در تشکیل بیوفیلم در اسینتوباکتر بومانی مورد نیاز است و نقش اصلی را در عفونت‏زایی باکتری بازی می‏کند. در مطالعه قبلی محققان حاضر نواحی متعددی از این پروتئین بررسی شد و با در نظر گرفتن معیارهای مختلف، چند ناحیه به عنوان نواحی حفاظت شده و ایمنی

Learn about Nashua CC RN program. You can enter nursing with either an associates degree or BSN. As a licensed vocational nurse (LVN), you may provide patient care under the supervision of a registered nurse (RN).

TY - JOUR. T1 - Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin. AU - Kootstra, A.. AU - Slaga, T. J.. PY - 1980/4/14. Y1 - 1980/4/14. N2 - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. AB - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.. UR - ...

1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4-piperidine]-2-one 89419-40-9 NMR spectrum, 1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4-piperidine]-2-one H-NMR spectral analysis, 1-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4-piperidine]-2-one C-NMR spectral analysis ect.

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).

The role of prostaglandin H synthase (PHS) in the metabolism of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP-7,8-diol) has been… Expand ...

Phosphorus › (R)-3-(tert-Butyl)-4-(3,5-diisopropyl-2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole, 97% (,99% ee) ...

Phosphorus › (R)-3-(tert-Butyl)-4-(4,6-dimethoxy-[1,1:3,1-terphenyl]-5-yl)-2,3-dihydrobenzo[d][1,3]oxaphosphole, 97% (,99% ee) ...

J Med Chem. 2010 Sep 9;53(17):6386-97.Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. ...

Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 21248-00-0(6-BROMOBENZO(a)PYRENE),please inquire us for 21248-00-0(6-BROMOBENZO(a)PYRENE).

3beta,5-dihydroxy-1-N-methyl-indoline-2beta-carbonyl amino-D-alanyl-erythro-beta-hydoxyisoleucinyl-glycine: indolinepeptide from Paecilomyces sp. J300; structure in first source

Ultimate 柱芯填料採用超高純全多孔球形矽膠爲基質，採用月旭公司獨有的固定鍵合相技術和矽膠表面處理技術進行生產，與Ultimate系列分析柱同種填料配合使用，攔截樣品中的一些強極性、強酸性和強鹼性物質，防止它們對分析柱內填料的汙染和損壞，延長分析柱壽命。Ultimate 柱芯填料鍵合相包括C18、C8、C4等。. ...

A series of 2,3-dihydrobenzo[b]selenophene-5-ol antioxidants was prepared by subjecting suitably substituted allyl 4-methoxyphenyl selenides to microwave-induced seleno-Claisen rearrangement/intramolecular Markovnikov hydroselenation followed by boron tribromide-induced O-demethylation. The novel antioxidants were assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system containing N-acetylcysteine as a thiol reducing agent in the aqueous phase. Antioxidant efficiency as determined by the inhibited rate of peroxidation, Rinh, increased with increasing methyl substitution (Rinh = 46−26 μM/h), but none of the compounds could match α-tocopherol (Rinh = 22 μM/h). Regenerability as determined by the inhibition time, Tinh, in the presence of the thiol regenerating agent decreased with increasing methyl substitution. Thus, under conditions where the unsubstituted compound 5a inhibited peroxidation for more than 320 min, ...

An enzyme immunoassay for the detection of benzo[a]pyrene covalently conjugated to macromolecules has been developed. The monoclonal antibody, raised through in vitro immunization reacted with benzo[a]pyrene metabolites bound to DNA, RNA and proteins. The lower detection limit for the assay was 1 pmol for benzo[a]pyrene bound to DNA or RNA, and 5 pmol when bound to protein.

EINECS (European INventory of Existing Commercial chemical Substances) as published in O.J. C 146A, 15.6.1990. EINECS is an inventory of substances that were deemed to be on the European Community market between 1 January 1971 and 18 September 1981. EINECS was drawn up by the European Commission in the application of Article 13 of Directive 67/548/EEC, as amended by Directive 79/831/EEC, and in accordance with the detailed provisions of Commission Decision 81/437/EEC. Substances listed in EINECS are considered phase-in substances under the REACH Regulation ...

Imipramine Imipramine Systematic (IUPAC) name 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine Identifiers CAS number 50-49-7 ATC code

Synonyms for Geminal diol in Free Thesaurus. Antonyms for Geminal diol. 2 synonyms for diol: dihydric alcohol, glycol. What are synonyms for Geminal diol?

Quetiapine EP Impurity C ;. 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl 2-(4-(dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)acetate ;. CAS # 1798840-31-9 ;. C40H42N6O3S2 ;. MW: 718.93. ...

LiChrosorb Diol LiChrosorb ist eine der erfolgreichsten und zuverlässigsten Packungsmaterialien der letzten 25 Jahre, was in der Literatur in Form von tausenden Applikationen gut dokumentiert ist. Die total porösen irregulären Partikel werden letztendlich in 5-, 7- und 10 µm - Fraktionen klassifiziert. Die Familie der LiChrosorb-Packungsmaterialien umfasst den Bereich der nichtpolaren (RP2, RP8, RP18, RP select B), polaren (Si 60, Si 100) und mittelpolaren Derivate (NH2 , CN, Diol ...

You are viewing an interactive 3D depiction of the molecule [[(2R,3S,4R,5R)-5-[2-amino-6-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(phosphonooxymethyl)tetrahydrofuran-2-yl]oxy-purine-1,3,7-triium-9-yl]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate (C15H25N5O21P4) from the PQR.

Hvad siger du til et forst rkers t, der spiller bukserne af pigerne, har 20 rs garanti og ikke der hele magnetbel gningen p dit Dankort ? Hils p Bryston !!

DUI Probable Cause - What are the police looking for? Features discussion of the law and real examples from DUI arrests by police and reasons for DUI arrest