Full Text - The cardiovascular effects of testosterone and dihydrotestosterone are generally attributed to their modulatory action on lipid and glucose metabolism. However, no ex vivo studies suggest that circulating androgen levels influence the activation and reactivity of blood platelets - one of the main components of the haemostasis system directly involved in atherosclerosis. The levels of testosterone, dihydrotestosterone and oestradiol in plasma from men and women aged from 60 to 65 years were measured by LC-MS; the aim was to identify any potential relationships between sex steroid levels and the markers of platelet activation (surface membrane expression of GPII/IIIa complex and P-selectin) and platelet reactivity in response to arachidonate, collagen or ADP, monitored with whole blood aggregometry and flow cytometry. The results of the ex vivo part of the study indicate that the concentrations of testosterone and its reduced form, dihydrotestosterone are significantly negatively
Dihydrotestosterone (DHT), or 5α-dihydrotestosterone (5α-DHT), also known as androstanolone or stanolone, is an endogenous androgen sex steroid and hormone. The enzyme 5α-reductase catalyzes the formation of DHT from testosterone in certain tissues including the prostate gland, seminal vesicles, epididymides, skin, hair follicles, liver, and brain. This enzyme mediates reduction of the C4-5 double bond of testosterone. Relative to testosterone, DHT is considerably more potent as an agonist of the androgen receptor (AR). In addition to its role as a natural hormone, DHT has been used as a medication, for instance in the treatment of low testosterone levels in men; for information on DHT as a medication, see the androstanolone article. DHT is biologically important for sexual differentiation of the male genitalia during embryogenesis, maturation of the penis and scrotum at puberty, growth of facial, body, and pubic hair, and development and maintenance of the prostate gland and seminal ...
TY - JOUR. T1 - Comparative pharmacokinetics of three doses of percutaneous dihydrotestosterone gel in healthy elderly men - A clinical research center study. AU - Wang, C.. AU - Iranmanesh, A.. AU - Berman, N.. AU - Mcdonald, V.. AU - Steiner, B.. AU - Ziel, F.. AU - Faulkner, S. M.. AU - Dudley, R. E.. AU - Veldhuis, J. D.. AU - Swerdloff, R. S.. PY - 1998/11/10. Y1 - 1998/11/10. N2 - Twenty-five men, 60-80 yr old, participated in a pharmacokinetic study to compare three doses (16, 32, and 64 rag/day, n = 8 or 9 in each group) of 5α-dihydrotestosterone (DHT) gel (0.7% hydroalcoholic gel with 2.3 g gel delivering 16 mg DHT) applied daily over one upper arm (16 mg); both arms and shoulders (32 mg); and bilateral arms, shoulders, and upper abdomen (64 mg), respectively. Multiple blood samples for the pharmacokinetic profile for DHT and testosterone (T) were drawn over a 24-h period before application, after first application, and after 14 days of daily application of DHT gel. Additional blood ...
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AIM: Acute exacerbations (AECOPD) of negatively influence the natural history of chronic obstructive pulmonary (COPD) and they are related to muscle dysfunction. In this pathway hypogonadism could play a pivotal role. Our study wants to evaluate possible relationships among prognostic indexes of AECOPD, represented by Acute Physiology and Chronic Health Evaluation (APACHE) II, inflammation (serum amyloid A, SSA) and anabolic hormones, especially less studied steroids, like dihydrotestosterone (DHT) e free-testosterone (f-T ...
Dihydrotestosterone gets a mixed rep. This guide will go over everything you need to know about DHT and whether using DHT blockers is a good idea.
4423 Purpose: To study the mechanism by which an antibiotic brefeldin A (BFA) inhibits proliferation of androgen-responsive prostatic cancer LNCaP cells, focusing on cell cycle and androgen receptor (AR). Materials and Methods: Androgen-mediated cellular events in LNCaP cells were induced using 5α-dihydrotestosterone (DHT) as an androgenic mediator. Effect of BFA on DHT-stimulated cell growth was first assessed, and its regulatory mechanism(s) was further explored by examining cell cycle and AR activity/expression using flow cytometry, AR binding assay, and Western blot analysis. Results: DHT (1 nM) stimulated LNCaP cell growth by ∼37% above control; however, BFA (30 ng/ml) was capable of completely inhibiting such DHT-stimulated proliferation. Cell cycle analysis showed that this growth inhibition was associated with ∼75% reduction in the cell number in the S phase, indicating a blocking of G1-S phase transition. Such a G1 growth arrest was confirmed by a drastic (,80%) down-regulation of ...
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Post hoc analyses were also performed leads to compare directly the behavioral effects of terfenadine and dihydrotestosterone. Last year the northstar rx llc has won a contract payments for packaging of ondansetron. This randomised controlled trial court conducted in bore the primary healthcare departments of three uk prisons shows equal effectiveness between circulating insulin glargine a
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Dutasteride was developed and patented for the first time in the United States of America. It was released into mass production in 2001 as part of the drug under the trade name Avodart, which is still used today. In 2015, the term of the patent for a substance ended and it was used in the production of generic drugs.. Increasing the level of the hormone dihydrotestosterone in men leads to uncontrolled proliferation of prostate tissue, followed by possible degeneration of them into a malignant form.. In addition, the increased background of dihydrotestosterone in men is the cause of alopecia (hair loss on the head) and hirsorutism (body hair in women).. Prostate hyperplasia is considered as a precancerous condition of the body, it requires increased attention and corrective therapeutic and sometimes surgical interventions. One of the substances that selectively reduces the level of dihydrotestosterone is Dutasteride.. The substance inhibits the activity of enzymes 5-alpha-reductase of the 1st and ...
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation (By similarity). Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity).
Trilostane is the chemical name for a medication that effectively treats Canine Cushings Disease. Worldwide, the only licensed veterinary version of trilostane is manufactured in the U.K. by the Dechra Group under the brand name of Vetoryl. Vetoryl is marketed in four dosage strengths: 10 mg., 30 mg., 60 mg., and 120 mg. capsules. Vetoryl is commonly used in the U.K. and Europe, and it is becoming more widely prescribed in the U.S. subsequent to FDA approval beginning in 2009. All dosage
Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy. Clin Cancer Res; 22(13); 1-3. ©2016 AACR.. See related article by Hedayati et al., p. 3310 ...
The most significantly molecular functions enriched by genes activated in DHT-treated ovaries. The direction of the arrow shows the significant level of the gen
AR and SET9 interact in vitro and in vivo. (A) LNCaP cells grown in steroid-depleted media and treated with and without 10 nM DHT for 6 h were subject to IP
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Looking for online definition of dihydrotestosterone in the Medical Dictionary? dihydrotestosterone explanation free. What is dihydrotestosterone? Meaning of dihydrotestosterone medical term. What does dihydrotestosterone mean?
Despite extensive research, the potential costs that keep secondary sexual traits honest and evolutionary stable remain somewhat elusive. Many carotenoid-based signals are regulated by testosterone (T), which has been suggested to impose a cost to the signaller by suppression of the immune system or an increase in oxidative stress. Results are, however, inconsistent, which may be due to the fact that T can be metabolised to both 5 alpha-dihydrotestosterone (DHT, a potent androgen) and oestradiol (E2, a potent oestrogen). To evaluate for the first time the independent effect of these testosterone metabolites on oxidative status, circulating carotenoids and a carotenoid-dependent sexual signal, we administered DHT and E2 to captive non-breeding adult kestrels Falco tinnunculus of both sexes. E2 increased oxidative damage and downregulated the antioxidant barrier without affecting colouration or circulating carotenoids. In contrast, DHT did not affect oxidative status, but increased skin redness, ...
Ingredients include:. Saw Palmetto. Is a popular herbal supplements that contains Beta-Sisterol, a plant sterol. Supplementation with Saw Palmetto has been shown in a number of studies to help improve urinary symptoms in men with prostate enlargement. Saw Palmetto helps by contributing to correct regulation of the androgen dihydrotestosterone (DHT), a compound suggested to play a key role in prostate enlargement.. Gamma Linolenic Acid (GLA). Is a strong inhibitor of 5-alpha reductase acyivity. An enzyme that irreversibly converts testosterone to Dihydrotestosterone (DHT), This conversion may not only result in prostate enlargement but can cause other problems related to low testosterone such as fatigue, reduced virility and male pattern baldness.. Blackcurrant Anthocyanins. Possess powerful antioxidant activity which fight oxidative stress helping prevent disease and reduce premature aging. In addition the unique composition of anthocyanins, rarely found elsewhere in nature, also promotes ...
Background: 5 alpha-reductase 1 (5alphaR1) and 5alpha-reductase 2 (5alphaR2) convert testosterone into the more potent androgen dihydrotestosterone. 5alphaR2 is the main isoenzyme in normal prostate tissue; however, most ...
TY - JOUR. T1 - Transformation of the androgen receptor to the deoxyribonucleic acid-binding state. T2 - Studies in homogenates and intact cells. AU - Grino, P. B.. AU - Griffin III, Jim. AU - Wilson, J. D.. PY - 1987/5. Y1 - 1987/5. N2 - Transformation of the [3H]dihydrotestosteronereceptor complex to the DNA-binding state was studied in intact monolayers and in homogenates of cultured human fibroblasts and mouse L-cells. When homogenates of either cell type were prepared in low salt buffer, incubated at 0 C with [3H]dihydrotestosterone, chromatographed on DNA-Sepharose, and eluted with a NaCl gradient, the receptor complex was eluted at 25 mM NaCl (peak A). After incubation of the homogenate at 25 C for 20 min, peak A decreased in amplitude. The major peak of the receptor from human fibroblasts eluted at 100 mM NaCl, while that from L-cells eluted at 170 mM NaCl (peak B). Flow-through fractions contained only minimal amounts of transformable dihydrotestosterone-receptor complex under the same ...
This study is being done to determine how much certain hormone levels in the prostate decrease when a patient takes dutasteride 0.5mg daily for 3 months prior to TURP. Male patients at least 50 years old willing to take either dutasteride or a placebo (dummy pill) once daily by mouth for 3 months prior to having a surgery to reduce the size of their prostate. During the surgery, very small pieces of the prostate that are removed will be tested to see how much dihydrotestosterone and testosterone (male hormones) are in the tissue ...
Dihydrotestosterone (DHT) is a hormone linked to hair loss and other health issues. By the age of 50, more than half the men in the U.S. will likely experience hair loss mediated by DHT. Treatments that block this hormone may prevent a receding hairline. Learn more about DHT, treatments, and male pattern baldness here.
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BACKGROUND. Prostasin is downregulated in hormone-refractory prostate cancers (HRPC). The mechanisms by which androgens regulate prostasin expression are unclear. METHODS. LNCaP cells were treated with dihydrotestosterone (DHT), and mRNA expression of prostasin, SREBPs, SNAIL, and SLUG was examined by real-time PCR following reverse transcription. A human prostasin promoter was evaluated in HEK-293 cells cotransfected with transcription factor cDNAs. Regulation of endogenous prostasin expression by transfected SREBP-2 or SLUG was evaluated. Expression of SNAIL and SLUG mRNA in DU-145 cells treated with epidermal growth factor (EGF) was examined. RESULTS. Prostasin mRNA expression in LNCaP cells was not responsive to DHT treatment. DHT marginally upregulated mRNA expression of SREBP-1c, SREBP-2, and SNAIL, but not SREBP-la, while dramatically increased SLUG mRNA expression, in a dose-dependent manner. Co-transfection of prostasin promoter and SREBP cDNA in HEK-293 cells resulted in stimulation of
Buy Dutasterida Online! Dutasterida works by blocking the conversion of the hormone testosterone to the more potent hormone dihydrotestosterone. Dihydrotestosterone is partly responsible for making the prostate enlarge.
Cell lines, plasmid constructs, and small interfering RNA duplexes. PC-3, LNCaP, and PzHPV-7 cells were purchased from American Type Culture Collection (Manassas, VA). The highly aggressive LNCaP-derivative LN3 cells were from Curtis Pettaway (The University of Texas M.D. Anderson Cancer Center, Dallas, Houston, TX). CWR22RV-1 cells were kindly provided by Dr. Michael Sramkoski (Case Western Reserve University, Cleveland, OH). PC-3 and CWR22Rv-1 cells were grown in RPMI 1640 supplemented with 10% fetal bovine serum (FBS); LNCaP and LN-3 cells were grown in DMEM supplemented with glutamine in 10% FBS and antibiotics; and PzHPV-7 cells were grown in keratinocyte serum-free medium from Sigma Chemical Co. (St. Louis, MO). In experiments that examined the role of dihydrotestosterone and AR in WA action, the androgen-responsive cells were grown in 10% charcoal stripped-serum containing medium lacking phenol red in the presence of dihydrotestosterone (Sigma Chemical). The small interfering RNA (siRNA) ...
BMB Rep. 2010 Oct;43(10):688-92. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosterone-in
He carried out additional studies demonstrating that estrogen-receptor complexes needed to be constantly present at nuclear acceptor sites in order to maintain the transcriptional activity of estrogen. Specificity of steroid action in target tissues may be increased by biochemically modifying the steroid. For example, in male genital skin, testosterone is converted by 5a-reductase to dihydrotestosterone which is a more potent androgen than testosterone itself. Some analogs of testosterone, however, are maximally active with no further metabolism. One such synthetic analog of testosterone is 7a- methyl-19nor-testosterone. Using rat liver and a prostate microsomal fraction, he showed that this steroid was not metabolized by 5a-reductase and thus it might be useful for treatment of 5-alpha reductase deficient patients. It is currently being evaluated for its androgenic potency in primates.. His work over the past decade has concentrated on the conversion of cortisol (the main glucocorticoid in ...
Buy Finara Online! Finara is a synthetic 4-azasteroid compound. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.
The HSD17B10 gene provides instructions for making a protein called HSD10. This protein is located within mitochondria, the energy-producing centers inside cells, where it has several different functions.. The HSD10 protein is important for the production (synthesis) of proteins in mitochondria. (While most protein synthesis occurs in the fluid surrounding the nucleus, called the cytoplasm, a few proteins are synthesized in the mitochondria.) During protein synthesis, whether in the cytoplasm or in mitochondria, molecules called transfer RNAs (tRNAs) help assemble protein building blocks (amino acids) into the chains that form proteins. The HSD10 protein is involved in making functional mitochondrial tRNA. It forms a complex with an enzyme called TRMT10C to modify tRNAs so that they are more stable and can function properly. In addition, the complex interacts with another enzyme called PRORP to perform an enzymatic function called mitochondrial RNase P (mtRNase P) that cuts precursor RNA ...
Mastabolic is an injectable preparation containing the steroid drostanolone propionate. Drostanolone is a derivative of dihydrotestosterone, most specifically 2alpha-methyldihydrotestosterone. As a result, the structure of this steroid is that of a moderate anabolic/potent androgen which does not aromatize to estrogen. Water retention and gynecomastia are therefore not a concern with this compound; as of course here estrogen is usually the culprit. Mastabolic may in fact exhibit antiestrogenic activity in the body, competing with other substrates for binding to aromatase. This would reduce the conversion rate of other steroids, Mastabolic acting in the same manner as the oral steroid Provirabolic.. Bodybuilders have a strong appreciation for non-aromatizing androgens, and find Mastabolic very useful as a cutting agent. It is likewise generally used a number of weeks prior to a competition, in an effort to bring out an improved look of density and hardness to the muscles. For this purpose ...
Male sex hormone. Polarised light micrograph of crystals of 5-alpha- dihydrotestosterone, also known as DHT. DHT is the most potent of the naturally-occurring androgens, the class of hormones associated with the development of male reproductive organs and secondary sex characteristics. DHT is secreted in the testes, and is made by the action of an enzyme, 5-alpha transcriptase, on testosterone. A deficiency of this enzyme may lead to a variety of syndromes including hermaphroditism. These may be reduced by hormone replacement therapy. Magnification x8 at 35mm size. - Stock Image A618/0303
1LHW: Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
Average Cost Proscar 5 mg Generic Proscar How To Buy Generic Proscar OTC. Proscar (Finasteride) is a type of steroid reductase inhibitor. It works by reducing the amount of the hormone dihydrotestosterone (DHT) in the body. This makes the prostate gland smaller, which helps to relieve urinary problems. Proscar is an effective treatment by Merck ...
Code modified from example provied by plot.ly #include ,SPI.h, #include ,Ethernet.h, #include "plotly_ethernet.h" #include "DHT.h" // DHT Sensor Setup #define DHTPIN 2 // We have connected the DHT to Digital Pin 2 #define DHTTYPE DHT22 // This is the type of DHT Sensor (Change it to DHT11 if youre using that model) DHT dht(DHTPIN, DHTTYPE); // Initialize DHT object plotly plotly; // initialize a plotly object, named plotly //initialize plotly global variables char layout[]="{}"; char filename[] = "Office Weather and Light"; // name of the plot that will be saved in your plotly account -- resaving to the same filename will simply extend the existing traces with new data float h, t, ll; int lightLevel; // Ethernet Setup byte mac[] = { 0xDE, 0xAD, 0xBE, 0xEF, 0xFE, 0xED }; // doesnt really matter byte my_ip[] = { 192, 168, 1, 77 }; // google will tell you: "public ip address" void startEthernet(){ Serial.println("Initializing ethernet"); if(Ethernet.begin(mac) == 0){ Serial.println("Failed to ...
Stanolone (Steroids) Synonyms: Dihydrotestosterone;androstanolone Chemical Name: 5a-androstan-17?-ol-3-one CAS: 521-18-6 EINECS: 208-307-3 Assay: 99% min. Molecular Formula:C19H30O2 Molecular Structure: Packing: foil bag or tin. Delivery: Express...
I have SOS v998 and AE v74. I emailed him today after being reminded of it due to this thread. There is a new SOS due out soon, and there is a fair bit to be added to AE as well, but that one wont be for a while.. The DHT cycling for PE is a good theory, but we have lots of good theories that dont stand up when tested for one reason or another. I believe he got the effects he claimed, but I for one can say that not everyone reacts the same in this instance. I didnt add DHT at the time, because I was unaware of this protocol and was cycling off for other reasons (a rest from it).. I know of no link that shows normal or abnormal levels of DHT being the cause of hairloss. Imho (though plenty will disagree), linking hairloss to DHT is as tenuous a link as excess calories is to obesity; there is certainly a correlation, but it isnt absolutely true either. Hairloss is (as far as we know), an immune response in genetically susceptible follicles rather than a DHT level issue. Thats why Fin, Dut, ...
The IUPHAR/BPS Guide to Pharmacology. trilostane ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
going to get on the shakes but really want to avoid anything with creatine as the stuff is reported to boost dht levels among other things. can someone recommend a shake thats not as artificial, one that youve found does not mess with you mpb?
DHT is one of the strongest hormones in the body, and as a result having too much of it in your body can lead to adverse effects.
Propecia® is produced by Merck S&D. Propecia® treats the most common type of hair loss in mencalled MPHL or MPB (male pattern baldness). It is also known as androgenetic alopecia (AGA). It affects about 50% of men over the age of 50. It is a condition, where hair follicles are being destroyed by the high levels of sex hormone dihydrotestosterone (DHT).. DHT binds to androgen receptors in susceptible hair follicles and activates genes responsible for follicular miniaturization. The active ingredient Finasteride is a type II 5-alpha reductase inhibitor and has a trichogenic activity (hair growth-promoting). It hinders the action of 5-alpha reductase enzyme, responsible for the conversion of testosterone to dihydrotestosterone (DHT). Due to inhibiting of this enzyme, Propecia® lowers scalp and serum DHT concentrations (up to 60%) and slows down the complete hair loss process.. Finasteride in higher doses (Finast®, Fincar®, Proscar®, Prosteride®) is used for the treatment and maintenance of ...
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3β-Androstanediol, also known as 5α-androstane-3β,17β-diol, and often shortened to 3β-diol, is an endogenous steroid hormone. It is a 5α-reduced and 17β-hydroxylated metabolite of dehydroepiandrosterone (DHEA) as well as a 3β-hydroxylated metabolite of dihydrotestosterone (DHT). 3β-Diol is a selective, potent, high-affinity full agonist of the ERβ, and hence, an estrogen.[2] It has higher affinity for this receptor than estradiol.[2][contradictory] In contrast to ERβ, 3β-diol does not bind to the androgen receptor (AR).[3] 3β-Diol has been reported to also bind to ERα with low nanomolar affinity, with several-fold lower affinity relative to ERβ.[4][5] It has approximately 3% and 7% of the affinity of estradiol at the ERα and ERβ, respectively.[6][contradictory] Unlike its 3α-isomer, 3α-androstanediol (3α-diol), 3β-diol does not bind to the GABAA receptor.[7] ...
The purpose of this study was to determine the effects of an alleged aromatase and 5-α reductase inhibitor (AI) on strength, body composition, and hormonal profiles in resistance-trained men. Thirty resistance-trained men were randomly assigned in a double-blind manner to ingest 500 mg of either a placebo (PL) or AI once per day for 8 wk. Participants participated in a 4-d/wk resistance-training program for 8 wk. At Weeks 0, 4, and 8, body composition, 1-repetition-maximum (1RM) bench press and leg press, muscle endurance, anaerobic power, and hormonal profiles were assessed. Statistical analyses used a 2-way ANOVA with repeated measures for all criterion variables (p ≤ .05). Significant Group × Time interaction effects occurred over the 8-wk period for percent body fat (AI: -1.77% ± 1.52%, PL: -0.55% ± 1.72%; p = .048), total testosterone (AI: 0.97 ± 2.67 ng/ml, PL: -2.10 ± 3.75 ng/ml; p = .018), and bioavailable testosterone (AI: 1.32 ± 3.45 ng/ml, PL: -1.69 ± 3.94 ng/ml; p = .049). ...
Here is a bit more interesting information regarding the bodys absorption of topical finasteride... In 2014, the Intl Jour of Clinical Pharmacology published findings from their investigation of this specific topic. 1) SERUM FINASTERIDE Levels with TOPICAL versus PILL form. The finasteride levels found in the serum (blood) of patient who used 0.25% topical finasteride once daily were well below the assays ability to detect and quantify at nearly every point. The spike in serum finasteride levels of patients taking the pill can be seen below. 2) SERUM DHT levels with TOPICAL versus PILL form. Once-a-day use of the 0.25% topical finasteride resulted in much a less severe decrease in DHT plasma levels (19%) that those seen in patients using the pill once a day (70%) or twice daily use of either topical or pill form. Our blend uses a lower percentage of finasteride than that used in this study and our patients only use the blend once (not twice) daily. 3) No significant change in serum ...
Early morning erections improved transiently in the DHT group at 3 months of treatment (P , 0.003), and the ability to maintain erection improved in the DHT group compared with the placebo group (P , 0.04). No significant changes were observed in general well-being between the placebo and the DHT group. Serum concentrations of LH, FSH, E2, T, and SHBG decreased significantly during DHT treatment. Treatment with DHT did not affect liver function or the lipid profile. Hemoglobin concentrations increased from 146.0 ± 8.2 to 154.8 ± 11.4 g/liter, and hematocrit from 43.5 ± 2.5% to 45.8 ± 3.4% (P , 0.001). Prostate weight and prostate-specific antigen levels did not change during the treatment. No major adverse events were observed ...
Consider an XY fetus. For the androgens (testosterone and dihydrotestosterone) to do their work in its brain, they must bind to special receptors tailored specially for androgens. The androgens fit into the receptors like a key into a lock. The receptors are actually proteins, made by genes. Even small variations in the gene (SRY) involved in making androgen receptors can lead to a hitch. And small variations in that gene are not uncommon. In some genetic variants, the receptor lacks the right shape to allow the androgens to bind to it. This prevents the process of masculinizing the gonads and the brain. In other genetic variants, no receptor proteins are produced at all, so the androgen has nothing to bind to. In these conditions, the androgens cannot masculinize the brain or the body, despite the XY genetic makeup. In consequence, the baby, though a genetic male, will probably have a small vagina and will be believed to be female when born. This baby will grow breasts at puberty, though she/he ...
Proscar (finasteride) averts the transformation of testosterone to DHT (dihydrotestosterone) in mens body. DHT is involved in the development of BPH (Benign Prostatic Hyperplasia).