Prenatal exposure to the synthetic estrogen diethylstilbestrol (DES) causes morphogenetic alterations and neoplasia in the human reproductive tract. In the hamster, neonatal DES exposure alters early uterine morphogenesis and induces endometrial adenocarcinomas in adults. We now demonstrate that the preneoplastic stages of this phenomenon in the hamster reflect an abnormal uterotropic response to estrogen that is characterized by hyperplastic lesions in the endometrial epithelium and includes an immune and/or inflammatory component. Interestingly, biochemical and in situ analysis revealed that the hyperplastic epithelium is also an active site of cell death by apoptosis. To further probe the mechanism of this phenomenon, uteri from 7-day-old control or DES-exposed donors were transplanted into the cheek pouches of control or neonatally DES-exposed adult hosts, and both host groups were treated to provide high circulating levels of estradiol. Among the four ectopic scenarios, histopathological ...
The effects of neonatal diethylstilbestrol (DES) exposure on the volume of the sexually dimorphic nucleus of the preoptic area of the hypothalamus (SDN-POA) and on GnRH-stimulated LH secretion were investigated in castrated female rats of known anogenital distance (AGD) at birth. The AGD was measured in females on the day of birth, and 0.1 microgram DES or corn oil was injected from Days 1 through 10 of life. The volume of the SDN-POA was significantly larger in animals that had received DES than in those that had received corn oil.
Although it is well established that women exposed to diethylstilbestrol in utero have an increased risk of spontaneous abortion, ectopic pregnancy, and preterm delivery, it is not known whether they also have an increased risk of infertility. The authors assessed this question in data from a collaborative follow-up study of the offspring of women who took diethylstilbestrol during pregnancy.. In 1994, 1,753 diethylstilbestrol-exposed and 1,050 unexposed women from an ongoing cohort study (National Cooperative Diethylstilbestrol Adenosis Study and Dieckmann cohorts) provided data on difficulties in conceiving and reasons for the difficulty. Age-adjusted relative risks were computed for the association of diethylstilbestrol exposure with specific types of infertility.. ...
This project screened for altered expression of small RNA species, microRNAs (miRNA), in the hamster uterus following neonatal exposure to the potent synthetic estrogen and established endocrine disruptor diethylstilbestrol (DES). Neonatal DES exposure results in a dysplastic/neoplastic response of the adult hamster uterus to the natural ovarian estrogen, estradiol (E2). In the present study, miRNA profiling was performed with total RNA extracted from the uteri of control and neonatally DES-treated female hamsters. We exploited a highly sensitive, reliable, and accurate microarray profiling technology and used it to screen for the differential expression of miRNA genes during both the initiation and promotion stages of estrogen-dependent endometrial adenocarcinoma in the neonatally DES-treated hamster. MiRNAs that were two-fold or more differentially expressed in DES-treated animals compared with the control animals were validated using a sensitive and highly specific quantitative RT-PCR ...
The effects of neonatal diethylstilbestrol (DES) exposure on the morphology and proliferating patterns of endometrial epithelial cells were investigated at various stages of development in mice. Female CD-1 mice were given daily subcutaneous injectio
Compared with the history of research on the range of health effects of DES daughters, there are relatively few published medical research studies conducted with DES sons. And yet, the finding that prenatal DES exposure also led to detrimental effects for a number of exposed males has existed since the 1970s (Andonian and Kessler, 1979; Bibbo et al., 1977; Gill et al., 1979; Gill, et al., 1988; Laitman et al., 1997). These effects include a variety of structural abnormalities of the reproductive system such as epididymal (benign) cysts, hypoplastic testes or undescended testes (chryptorchidism), microphallus or underdeveloped penis which may be associated with an intersex condition, and hypospadias (opening of the penis is on the underside rather than at the end). Although DES exposure has been suspected as a possible source of male infertility and testicular cancer (Giusti, Iwamato, and Hatch, 1995, it is still uncertain whether prenatal DES exposure has led to increased risk of infertility ...
Lédition 2012 des Comptes nationaux des pays de lOCDE : Volume IV, Comptes des administrations publiques est une publication annuelle de lOCDE, consacrée aux finances publiques et basée sur le Système de Comptabilité Nationale 1993 (SCN 1993) pour tous les pays sauf lAustralie, du Canada, dIsraël, du Mexique et des États-Unis (SCN 2008). La publication comprend des tableaux avec les agrégats et les soldes des administrations publiques pour les comptes de production, de revenu et les comptes financiers. Elle comprend également les recettes détaillées dimpôts et de cotisations sociales ainsi que la ventilation des dépenses des administrations publiques par fonction, selon la classification harmonisée au niveau international CFAP. Ces comptes détaillés sont disponibles pour le secteur des administrations publiques avec, dans la mesure du possible, le détail par sous-secteur : administration centrale, administration détats fédérés, administrations locales, administrations ...
Diethylstilbestrol (DES) is a synthetic compound and considered as an endocrine disruptor that interferes with the normal development of human organs and even immune tissues. DES has been investigated for its immunosuppressive effects, thymic atrophy, and various types of cancer including breast cancer, ovarian cancer, uterine cancer, etc. In this study, we investigated DES regulated mechanisms in T cells and examined whether DES exposure of T cells leads immune suppression and affects immune functions. To this end, we investigated the effect of DES on T cells in vitro and specifically examined DES-induced apoptosis in T cells, expression of genes involved in apoptosis, and differentiation of T helper cells in vitro. We observed significant increase in apoptosis in activated T cells in dose-dependent manner in vitro. Upon examination of FasL expression in activated T cells, there was a significant increase in FasL expression in activated T cells post DES treatment. Furthermore, upon examination of
Lédition 2014 des Comptes nationaux des pays de lOCDE : Volume IV, Comptes des administrations publiques est une publication annuelle de lOCDE, consacrée aux finances publiques et basée sur le Système de Comptabilité Nationale 2008 (SCN 2008) pour tous les pays sauf le Chili, la Corée, le Japon, et la Turquie (SCN 1993). La publication comprend des tableaux avec les agrégats et les soldes des administrations publiques pour les comptes de production, de revenu et les comptes financiers. Elle comprend également les recettes détaillées dimpôts et de cotisations sociales ainsi que la ventilation des dépenses des administrations publiques par fonction, selon la classification harmonisée au niveau international CFAP. Ces comptes détaillés sont disponibles pour le secteur des administrations publiques avec, dans la mesure du possible, le détail par sous-secteur : administration centrale,. ...
Potential trans-generational influence of diethylstilbestrol (DES) exposure emerged with reports of effects in grandchildren of DES-treated pregnant women and of reproductive tract tumors in offspring of mice exposed in utero to DES. Accordingly, we examined the trans-generational influence of DES on development of external genitalia (ExG) and compared effects of in utero DES exposure in CD-1 and C57BL/6 mice injected with oil or DES every other day from gestational days 12 to 18.Mice were examined at birth, and on 5-120 days postnatal to evaluate ExG malformations.. Of 23 adult (,60 days) prenatally DES-exposed males, features indicative of urethral meatal hypospadias ranged from 18% to 100% in prenatally DES-exposed CD-1 males and 31% to 100% in prenatally DES-exposed C57BL/6 males. Thus, the strains differed only slightly in the incidence of male urethral hypospadias. Ninety-one percent of DES-exposed CD-1 females and 100% of DES-exposed C57BL/6 females had urethral-vaginal fistula. All ...
The synthetic estrogen diethylstilbestrol (DES) was widely prescribed in the 1940s, 50s, and 60s to prevent miscarriage and premature delivery. Its…
DES is of particular interest in the study of prenatal hormones effects on human behavior because it may be a good tool for assessing the influence of…" ...
Introduction. Stilbestrol is a synthetic non-steroidal estrogen substance, which can produce all pharmacological and therapeutic effects as the same natural estradiol does. It is mainly used for functional bleeding and amenorrhoea caused by estrogen low disease and hormone imbalance. It can also be used for stillbirth before induction of labor, in order to improve the muscular layer of uterine sensitivity to oxytocin. Pregnant women taking the drug, the female offspring in adolescence of cervical and vaginal adenosis and cancer incidence will rise and the male offspring reproductive tract abnormalities and abnormal sperm rate also will increase. Diethylstilbestrol can cause nausea, vomiting, loss of appetite, headache and other symptoms and long term using can make endometrial hyperplasia that may result in uterine bleeding and hypertrophy. The international standard provides stilbestrol residues detection limit is 1 μ g/kg in liver and muscle tissue in cattle and pigs.. Experimental. Sample ...
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Diethylstilbestrol (DES), also known formerly (and inappropriately) as stilboestrol, is a synthetic nonsteroidal estrogen of the stilbestrol group which was first synthesized in 1938. It is also classified as an endocrine disruptor. Human exposure to DES occurred through diverse sources, such as dietary ingestion from supplemented cattle feed and medical treatment for certain conditions, including breast and prostate cancers. From about 1940 to 1971, DES was given to pregnant women in the mistaken belief it would reduce the risk of pregnancy complications and losses. In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this drug in utero. The United States Food and Drug Administration subsequently withdrew approval of DES as a treatment for pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed. The ...
BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen that was used in pregnancy, is a prototype endocrine-disrupting chemical. Although prenatal exposure to DES is known to increase risks of vaginal/cervical adenocarcinoma and adverse reproductive outcomes in women, and urogenital anomalies in men, data on nonreproductive medical conditions are lacking. METHODS: We estimated hazard ratios and their associated 95% confidence intervals for the associations between prenatal DES exposure and the occurrence of cardiovascular disease, diabetes, osteoporosis, and related conditions among 5590 female and 2657 male offspring followed from 1994 through 2006, adjusted for birth year, cohort, sex, body mass index, smoking status, alcohol use, education, and number of general physical examinations in the past 5 years ...
For ,20 years, research in our laboratory has focused on the effects of estrogenic compounds on development and differentiation. Our working premise has been that the developing organism is extremely sensitive to perturbation by chemicals with estrogenic or endocrine disrupting activity and that exposure to these chemicals during critical stages of differentiation may have permanent long-lasting consequences, some of which may not be expressed or detected until later in life. Diethylstilbestrol (DES) is a well-known example of such a chemical; thus, we have used DES as a model chemical to study environmental estrogens.. DES, a synthetic estrogen, was widely prescribed from the 1940s through the 1970s for the prevention of threatened miscarriage. A range of 2-8 million treated pregnancies worldwide has been estimated. Today it is well recognized that prenatal DES treatment results in a low incidence of neoplasia in the female offspring and a high incidence of benign abnormalities in both the male ...
During the 1970s and 1980s an increased amount of public and scientific attention was paid to the health and medical problems of individuals whose mothers were prescribed diethylstilbestrol (DES). A potent synthetic nonsteroidal estrogen, DES was first developed in 1938 and initially became available in the U.S. for treating a range of gynecologic conditions in 1941 (Apfel and Fisher, 1984). A few years later its approval by the FDA was broadened to include treatment of pregnant women for the purpose of preventing miscarriages. Though its efficacy had long been questioned by some in the medical community (Bambigboye and Morris, 2003; Dieckmann, 1953), DES remained popular with doctors until discovery in the early 1970s of an apparent association between prenatal exposure to DES and a rare form of vaginal cancer in females whose mothers used DES (Heinonen, 1973; Herbst and Bern, 1981). Subsequent research confirmed the transplacental mechanism of DES transmission (Maydl, et al., 1983) and ...
DES was the first synthetic estrogen and was given to pregnant women from 1938-1971 to prevent miscarriages. It was found to cause health issues for the women who took DES and for the children born of these pregnancies (called DES daughters, DES sons).
Benzestrol (INN, BAN) (brand names Chemestrogen, Ocestrol, Octestrol, Octoestrol, Octofollin) is a synthetic nonsteroidal estrogen of the stilbestrol group which was formerly used medically but has since been discontinued. The stilbestrol estrogens, the most well-known of which is diethylstilbestrol (DES) were used extensively in the mid-1900s and were finally banned by the FDA due to them causing tumors in the children of women who used them. Benzestrol and other stilbestrol were used as synthetic estrogens in order to prevent premature births. Based on the idea that premature births happened because the mother did not produce enough estrogen on her own, doctors prescribed benzestrol to mothers in order to increase their estrogen levels. Studies have been done in the past on normal, mature and castrate female rats. Benzestrol produced the same type of estrus in the castrate rat when injected at 0.8 to 1.0 micrograms as when the rat was injected with 2.0 to 2.5 micrograms of estrone. This is ...
When young female A × C rats were given 9.6 rads of 0.43-MeV neutrons, 32 of 33 survived a 50-week follow-up period, 2 rats developed a total of 3 mammary adenocarcinomas, and 3 rats developed a total of 4 mammary fibroadenomas. For 25 rats implanted with a 20-mg pellet containing 5 mg diethylstilbestrol and 15 mg cholesterol, average survival was 284 days; 22 rats developed a total of 182 mammary adenocarcinomas, and 21 rats developed a pituitary tumor. When diethylstilbestrol was given 2 days before neutron radiation to 35 rats, the average survival was 239 days; 32 rats developed a total of 842 mammary adenocarcinomas, 1 rat developed a single mammary fibroadenoma, and 34 rats developed a pituitary tumor. All of the 31 control rats survived the 50-week study period, and none developed tumors. Twenty-one of the rats that received both diethylstilbestrol and neutron radiation and 1 rat that received only diethylstilbestrol exhibited a multiple mammary adenocarcinoma response with a range of 18 ...
The report firstly introduced the Diethylstilbestrol Dipropionate basics: definitions, classifications, applications and industry chain overview; industry policies and plans; product specifications; manufacturing processes; cost structures and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, capacity utilization, supply, demand and industry growth rate etc. In the end, the report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis ...
Learn about Stilbestrol (Canada) for animal usage including: active ingredients, directions for use, precautions, and storage information.
The teratogenic effects of diethylstilbestrol have continued to exact a heavy toll throughout the lifetime of women who were exposed to the drug in utero, investigators reported.
DES is extremely important because it provides us with a historical lesson of how a synthetic estrogen, when given during pregnancy, caused a significant increase in breast cancer 20-30 years after its first use.
We evaluated the utility of whole embryo culture for the screening technique of the potency of endocrine active chemicals in rat embryos. Rat embryos on embryonic day 11 (ED11) were exposed to two estrogenic chemicals, estradiol benzoate (EB) and diethylstilbestrol (DES), for 42 hr in culture. The treated embryos showed some morphological defects in the cardiovascular system, such as edema around umbilical vessels (EB- and DES-treated groups), enlargement of the heart (EB) and hemorrhage of the head (DES) at high doses. To determine the mediation of estrogen receptors to these morphological defects, we also studied the expression of estrogen receptor a (ER-a) in embryos both by immunohistochemistry and by Western blotting. Immunohistochemistry revealed positive grains stained with anti-ER- a antibody in both the cytoplasm and nucleus of heart and yolk sac in EDs 12 and 13 rat embryos. The staining pattern of anti-ER-a antibody in embryos was different from the positive control, the uterus of ...
Diethylstilbestrol (DES) is a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed).
Factors associated with RR 1.1-2.0 for breast cancer are as follows{ref6}{ref7}{ref8}: Alcohol consumption Age 30-35 at first full-term pregnancy Diethylstilbestrol exposure in utero Early menarch... more
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Mesenchymal stem cells (MSC) produced from bone tissue marrow stem cells (BMSC) and adipose tissue stem cells (ASC) of individuals and rhesus macaques were evaluated because of their cell cycle properties during protracted culture around 50 cumulative population doublings, and the cultures stop dividing (7). recommended that individual MSCs produced from the marrow might become […]. Read More ». ...
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
The present study, the largest to date examining DES outcomes according to the presence of DM, demonstrates that DM remains an independent predictor of clinical restenosis (i.e., both TLR and TVR), as well as adverse safety events, including cardiac death or MI, in the DES era. However, a strong interaction was present such that rates of TLR and TVR were increased in patients with versus those without DM with complex lesions (ACC/AHA class B2/C), but not in patients with more simple lesions (A/B1). No interaction was present between lesion complexity and the presence of diabetes on safety outcomes, although patients with DM had higher rates of cardiac death, MI, and stent thrombosis than those without DM.. Our analysis, with 6,334 propensity-matched patients, was adequately powered to study the impact of DM after DES treatment for both safety and efficacy endpoints. Although it is well accepted that DM is a risk factor for adverse outcomes after PCI, in the present analysis, the presence of ...
To treat young healthy prepubescent girls with a known carcinogen to stunt their adult height sounds like a bizarre science fiction experiment, but it is unfortunately true. From 1959 through the 1970s physicians and researchers from the Royal Childrens Hospital and the University of Melbourne, gave adolescent girls of tall stature a powerful estrogenic hormone with a growing list of known side effects called diethylstilbestrol (stilboestrol) or DES.. DES had been used in obstetrics to prevent miscarriage, in farm animals to bulk up livestock before slaughter and to caponise (castrate) chickens from the 1940s through 1970s. Early on, the drug was found to be ineffective in preventing miscarriage and serious side effects including cancer were noted. Indeed, cancer in farm hands caring for animals treated with DES and concern about the effect DES infused meat might have on human health caused the FDA to ban its use in poultry farming in 1958, well before banning its use in human women. Despite ...
In 1938, DES (diethylstilbestrol) was the first synthetic estrogen to be created. DES was prescribed to millions of pregnant women, primarily from 1938 - 1971, but certainly not limited to those years. In some cases DES prescriptions were written into the 1980s in the U.S.
(diethylstilbestrol), a nonsteroidal synthetic estrogen; once prescribed for some women during pregnancy to prevent miscarriages; banned for such use when discovered that…
A non-steroidal synthetic estrogen similar to diethylstilbestrol. Since the last update we have not found published data about its excretion in breast milk. It has been used orally to inhibit postpartum lactation (Oladapo 2012, Niebyl 1979, Yuen 1977, Utian 1975) and to treat menopausal symptoms, female hypogonadism and prostate carcinoma. Very long acting due to accumulation in adipose tissue. Not currently commercially available.
In one of our email conversations on our independent childbirth educators Yahoo group, we began discussing Diethylstilbestrol (DES), which is a synthetic hormone that was used to reduce miscarriages or help with other pregnancy problems from the 1930s through the 1970s. The woman who brought it up said that she discovered when looking at her…
Background Sex differences in occurrence of coronary disease may reflect age-associated intravascular mobile activation leading to dropping of cell membrane-derived bioactive microvesicles (MV or microparticles) in to the bloodstream. individuals in the Mayo Center Biobank was gathered into tubes including protease inhibitors as the anticoagulant. MV had been isolated by standardized differential centrifugation and seen as a digital movement cytometer. Each cellular origin of MV was verified by two different antibodies with strong correlation between the two distinct antibodies (e.g. for platelet-derived MV exposure to diethylstilbestrol (DES; maternal treatment); current smoking more than ten cigarettes/day; body mass index >35 (kg/m2); history of clinical cardiovascular disease including myocardial infarction angina or congestive heart failure; history of cerebrovascular disease including stroke or transient ischemic attack; history of thromboembolic disease (deep vein thrombosis or pulmonary ...
... No insurer, agent or broker authorized to issue policies on the lives of persons in the commonwealth shall cancel, refuse to issue or renew, charge any excessive rates or restrict any length of coverage or in any way practice discrimination against persons primarily because the insured person has had a suspected, alleged or confirmed exposure to the potential hazards and afflictions of diethylstilbestrol or compounds commonly referred to as DES. The practices prohibited under this section shall include not only those overtly discriminatory but also practices and devices which are fair in form but discriminatory in practice. ...
1TZ8: The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors
Hi all, I think this may well be my first question in this section...here goes. I have read much discussion about the use of depo-medrol and other treatments for Lumbosacral Stenosis. My question is for our 13 year old Maggie. A bit of history first (sorry, please bear with me). About 18 months ago, Maggie was x-rayed for a combined Pennsylvania Uni / Australian Greyhound Vet Association study into the prevalence of hip arthritis in greys. Maggie didnt have any hip arthritis, but the vet who took the x-ray commented that she appeared to have the beginnings of LS - at the time the only symptom I could match to this diagnosis was occasional stiffness in the lower lumbar area over the years - resolved with manipulation and occasionally a short course of anti-inflams. Fast forward to about three weeks ago, and Maggie suddenly developed quite serious urinary incontinence (while lying down and/or sleeping, not while standing). She was put on Stilboestrol and remains on a high dose. This hasnt ...
Ved behandling kan der - baseret på prækliniske data fra dyreforsøg - være risiko for reproduktionstoksicitet. Kvinder skal tilrådes at anvende sikker kontraception under behandlingen og i mindst 30 dage herefter. For mandlige patienter kan der være risiko for suppression af spermatogenesen. Mænd skal tilrådes at anvende kondom under behandlingen og i mindst 90 dage herefter. ...
Pam Katsoufis has had six miscarriages and spent thousands of dollars trying to conceive a child, but still she is childless.Doctors kept giving her different excuses for every miscarriage and she
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For over 40 years the U.S. federal government has approved various natural and synthetic estrogen and androgen hormones in beef cattle to improve the growth …. ...
Les interventions de lésion des tissus mous buccaux se manifestent par des taches ou des excroissances de taille, of various shapes and color.
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Die Sedimentationskonstante S20.w° des Kartoffelvirus M (KVM) beträgt 167±1 S. Die Konzentrationsabhängigkeit ergibt sich aus der Beziehung s20.wc=(167−33×c) S. Die Schwebedichte des KVM in...
Facteurs de pronostic visuel des endophtalmies aiguës bactériennes post-chirurgie de cataracte Aurélie Combey-De-Lambert To cite this version: Aurélie Combey-De-Lambert. Facteurs de pronostic visuel des
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