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We have followed a population in an area endemic for Brugia malayi for three years after intensive treatment with diethylcarbamazine (DEC). Microfilariae were cleared from the circulation within four months in all eligible study participants (n = 60). There appeared to be a strong correlation between the maximum reduction in specific IgG4 and the number of days drug was taken under supervision (ρ = 0.41, P < 0.001), indicating that high total dosage of DEC is necessary for optimal reduction of active infection. In individuals with good compliance (at least 180 mg/kg of body weight, n = 34), we observed variable IgG4 patterns. All pre-treatment IgG4+ children (9-14 years old) and 40% of the IgG4+ adult population (≥ 15 years old) showed a gradual decrease in anti-filarial IgG4; 53% of these showed complete clearance of worm burden by the end of the study. In contrast, another group of male IgG4+ adults showed IgG4 patterns that started to increase between nine months and two years after treatment,

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Bronchoalveolar lavage studies in 33 patients with acute untreated tropical eosinophilia have demonstrated intense eosinophilic alveolitis. Following treatment with a standard 3-week course of diethylcarbamazine, there was a significant fall in lung eosinophils (p ,0.001). However; a mild alveolitis characterised by hypercellular lavage fluid due to a significant increase in absolute alveolar macrophages (p , 0.001) and due to an increase in both the absolute number (p ,0.01) and percentage of eosinophils (p = 0.02) was persisting at 1 month despite treatment. Long-term follow-up is essential to know the fate of alveolitis.. ...

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Ramaiah, K. D., Das, P. K., Appavoo, N. C., Ramu, K., Augustin, D. J., Vijay Kumar, K. N. and Chandrakala, A. V. (2000), A programme to eliminate lymphatic filariasis in Tamil Nadu state, India: compliance with annual single-dose DEC mass treatment and some related operational aspects. Tropical Medicine & International Health, 5: 842-847. doi: 10.1046/j.1365-3156.2000.00659.x ...

MAIN RESULTS: Twenty-one studies were included; two compared DEC-medicated salt with other forms of DEC, five had some control group, and 14 were before-and-after studies. Five were efficacy and safety studies of individuals who were all microfilaraemic at baseline; the rest studied endemic communities.Percentage reductions in microfilariae prevalence were large (43% to 100%) and consistent in most studies with high levels of coverage. Large reductions in microfilariae density were also observed, though most studies reported changes in microfilariae density only for people with microfilaraemia at baseline. Vector infection and infectivity also declined, but the samples were usually small. Changes in disease prevalence were inconclusive as most studies were not powered for this outcome. Adverse events seemed mild.Only two studies compared DEC-medicated salt with other forms of DEC (such as annual or standard 12-day dose), but in both performance of DEC-medicated salt was better.A few studies ...

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The dose of this medicine will be different for different patients. Follow your doctors orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.. ...

Filariasis is diagnosed by direct demonstration of the microfilariae in the nocturnal blood sample or skin specimen. Diethylcarbamazine (DEC) is the recommended medicine for treating filariasis.

Lymphatic filariasis infects more than 128 million people worldwide in more than 80 endemic countries and continues to be a formidable problem especially in Asian subcontinent and Africa. Around 20% of world population is at risk to lymphatic filarial infection and 44 million populations is affected with various clinical forms of the disease while 76 million carry the parasites in their blood with silent clinical damages of lymphatics and renal systems. Within the last few years, significant achievements have been made in the identification of virulence factors and understanding of pathogenesis due to development of various immunopathological animal models. In addition, better diagnostic and control strategies including single dose and combination therapy, gave new ray of hope for elimination of this morbid disease. However, the presently available drugs, both diethylcarbamazine and albendazole are principally microfilaricidal with little or negligible effect on adult filarial parasites and ...

The purpose of the βDEC treatment systems is to achieve urban wastewater purification up to 10,000 equivalents inhabitants, so that the quality of treated water fully accomplishes with the requirements in the current legislation.

Estimates of parasite density-related contributions to the infectious reservoir show that improving malaria diagnostics 100-fold in mass treatment programs can interrupt transmission in high-endemic ...

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We studied effects of compliance on the impact of mass drug administration (MDA) with diethylcarbamazine and albendazole for lymphatic filariasis (LF) in an Egyptian village. Baseline microfilaremia (mf) and filarial antigenemia rates were 11.5% and 19.0%, respectively. The MDA compliance rates were excellent (> 85%). However, individual compliance was highly variable; 7.4% of those surveyed after five rounds of MDA denied having ever taken the medications and 52.4% reported that they had taken all five doses. The mf and antigenemia rates were 0.2% and 2.7% in those who reported five doses of MDA and 8.3% and 13.8% in those who reported zero doses. There was no significant difference in residual infection rates among those who had taken two or more doses. These results underscore the importance of compliance for LF elimination programs based on MDA and suggest that two ingested doses of MDA are as effective as five doses for reducing filariasis infection rates.

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Tropical (pulmonary) eosinophilia, or TPE, is characterized by coughing, asthmatic attacks, and an enlarged spleen, and is caused by Wuchereria bancrofti, a filarial infection. It occurs most frequently in India and Southeast Asia. Tropical eosinophilia is considered a manifestation of a species of microfilaria. This disease can be confused with tuberculosis, asthma, or coughs related to roundworms. Tropical pulmonary eosinophilia is a rare, but well recognised, syndrome characterised by pulmonary interstitial infiltrates and marked peripheral eosinophilia. This condition is more widely recognised and promptly diagnosed in filariasis-endemic regions, such as the Indian subcontinent, Africa, Asia and South America. In nonendemic countries, patients are commonly thought to have bronchial asthma. Chronic symptoms may delay the diagnosis by up to five years. Early recognition and treatment with the antifilarial drug, diethylcarbamazine, is important, as delay before treatment may lead to progressive ...

Ultrasound examination showed swelling of both epididymis with the outer area appearing irregularly echogenic due to fibrosis (figure 1B). The right cord appeared swollen and measured 8.75 mm, normal being below 5 mm. A colour Doppler study revealed absence of vascular flow on the right side testis (figure 1C). Seminal fluid analysis was done. The total sperm count was 9.4 million/mL having low viscosity with non-motile dead spermatozoa about 40%. The circulating adult filarial antigen test (OG4C3) was positive (512 antigen units). OG4C3 test is a highly sensitive and specific quantitative monoclonal antibody-based ELISA test for the diagnosis of filariasis. A diagnosis of right filarial funiculitis with bilateral chronic epididymitis and secondary infertility was made. The patient was treated with amoxicillin and clavulanic acid 2 g daily, orally for 1 week, along with a course of diethylcarbamazine for 2 weeks as recommended by WHO guidelines. Flavonoid supplements were added for 2 weeks to ...

Considering that the Diropilaria is now endemic to Europe and that it can use almost all blood sucking mosquito species as a vector, no dog is really safe. There are several substances that can be used for prophylactics in the form of tablets for peroral administration, such as Ivermectin, milbemycin oxime, moxidectin, diethylcarbamazine citrate (DEC). A new substance named Selamectin supposedly is as effective as the peroral tablets but is administered directly on the skin.. It is of very high importance to be sure that your dog is Diropilaria-free before you start giving it one of the prophylactic substances. The reason being that should the dog be infected and treated with one of these substances in the prophylactics dose, this will cause a large amount of adult Dirofilaria worms to die at the same time. The dead worm may clog major blood vessels and/or cause severe sepsis once they start to decompose. ...

Hi - We just lost our 6 year old chocolate lab last night and we are pretty convinced that it was caused by HeartGuard which caused Immune Mediated Hemolytic Anemia. Have you heard of this happening to other labs? Thank you for your response. Im so sorry to hear about your Lab. I know that it must have been quite a shock to have an apparently healthy companion suddenly become so very ill. In regard to the Heartgard causing this condition, there is no indication in the literature that ivermectin induces risk for autoimmune hemolytic disease. In fact, in some clinical studies, ivermectin and diethylcarbamazine citrate, both active components of different types of heartworm preventative, are actually used as treatment for parasite-induced autoimmune hematologic disorders (since parasites may cause secondary AIHA). It is important to keep in mind that many other factors have been implicated in AIHA. Primary or immune-mediated hemolytic anemia (IMHA) occurs when an immune reaction is targeted ...

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EOSINOFILIA PULMONAR TROPICAL PDF - PDF | The authors present a comprehensive review of Tropical Pulmonary Eosinophilia Eosinofilia pulmonar tropical filariótica e o seu diagnóstico

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Lymphatic filariasis elimination programme in Andaman and Nicobar Islands, India: drug coverage and compliance post eight rounds of MDA. Trop Doct. 2013

BACKGROUND: In most countries of sub-Saharan Africa the control of lymphatic filariasis (LF) is based on annual mass drug administration (MDA) with a combination of ivermectin and albendazole, in order to interrupt transmission. Here we present the first detailed study on the effect of 3 repeated MDAs with this drug combination, as implemented by the Tanzanian National Lymphatic Filariasis Elimination Programme (NLFEP).

In a double-blind trial on 37 asymptomatic microfilaraemic subjects (minimum 400 microfilariae [mf] per mL) with Wuchereria bancrofti infection, the safety, tolerability and macrofilaricidal efficacy of 12 fortnightly doses of ivermectin, 400 microg/kg (ivermectin group), was compared with 12 fortnightly doses of diethylcarbamazine (DEC), 10 mg/kg (DEC group), over a period of 129 weeks after treatment. A control group (LDIC group) was treated with low dose ivermectin to clear microfilaraemia, for ethical reasons. Both ivermectin and DEC in high multiple doses were well tolerated and clinically safe. Macrofilaricidal efficacy was assessed by prolonged clearance of microfilaraemia, appearance of local lesions, and reduction of circulating W. bancrofti adult antigen detected by an antigen capture enzyme-linked immunoassay based on the monoclonal antibody AD12. Mf counts fell more rapidly after ivermectin than after DEC, but low residual mf levels were equivalent in these groups after week 4. ...

Efforts to eliminate two mosquito-borne diseases - malaria and lymphatic filariasis - in Haiti and the Dominican Republic are ongoing, with the first of four binational meetings on the issue to take place in 2012, held in Santo Domingo on the 29th and 30th of March of this year, with participants from the technical teams of the National Center for Tropical Disease Control, the Dominican Republics Ministry of Health and the National Malaria Control Program of the Haitian Ministry of Health. Also participating in the strategic meeting are experts from The Carter Center, The Panamerican Health Organization (OPS) and the U.S. Centers for Disease Control and Prevention (CDC). Learn More ...

Efforts to eliminate two mosquito-borne diseases - malaria and lymphatic filariasis - in Haiti and the Dominican Republic are ongoing, with the first of four binational meetings on the issue to take place in 2012, held in Santo Domingo on the 29th and 30th of March of this year, with participants from the technical teams of the National Center for Tropical Disease Control, the Dominican Republics Ministry of Health and the National Malaria Control Program of the Haitian Ministry of Health. Also participating in the strategic meeting are experts from The Carter Center, The Panamerican Health Organization (OPS) and the U.S. Centers for Disease Control and Prevention (CDC). Learn More ...

PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.

Malaria Consortium - One of the worlds leading non-profit organisations specialising in the prevention, control and treatment of malaria and other communicable diseases among vulnerable populations. - The impact of mass drug administration and long lasting insecticidal net distribution on wuchereria bancrofti infection in humans and mosquitoes an observational study in northern uganda

Wuchereria bancrofti vespid, Immune response, Serum immune complexes diagnosis, Diethylcarbamazine (DEC), Wolbachia in filarial parasites, Interdigital skin lesions, Urban Filariasis, Doxycycline, mass drug administration program, Filarial Lymphedema Care, Detection of filarial parasites, Albendazole, research ...

Annual Mass Drug Administration (MDA) is one of the strategies used to combat Neglected Tropical Diseases (NTDs) such as trachoma, onchocerciasis, lymphatic filariasis, schistosomiasis, soil-transmitted helminthiasis (STH). NTDs affect more than a billion people around the world, mainly in developing countries, including Ethiopia.. The Supervisors Coverage Tool (SCT) is a rapid, simple, and inexpensive monitoring and supervising tool recently endorsed by the World Health Organization (WHO). The tool is generally implemented by a district or sub-district level supervisor prior to the end of an MDA round. The SCT can help detect issues related to poor compliance, the drug distribution strategy, and the performance of community drug distributors. The tool can also be used to identify districts in need of additional (mop-up) treatments.. The SCT was included and implemented nationally in Ethiopia in the 2017-2018 annual MDA rounds. The MDA in Benishangul-Gumuz, which was one of the regions where ...

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Many people with the disease develop elephantiasis or lymphoedema, causing pain and profound disfigurement - such as large swelling of the arms, legs or genitals - and leading to permanent disability. These patients are not only physically disabled, but suffer mental, social and financial losses contributing to stigma and poverty.. A large proportion of the billion people living with the threat of transmission are in India, Indonesia and Myanmar where the triple drug combination could be used. Currently, people with Lymphatic filariasis require multiple rounds of treatment - but if the drugs ivermectin, diethylcarbamazine, and albendazole are used together recent clinical studies have shown that the drugs are more effective at killing the worms.. The new modelling work shows that this meant that the number of rounds of mass drug administration needed to treat the disease may fall from many rounds to only two or three. The World Health Organisation (WHO) has targeted the disease for elimination ...

The administration of drugs to whole populations irrespective of disease status is referred to as mass drug administration (MDA). This article describes the administration of antimalarial drugs to whole populations an intervention which has been used as a malaria-control measure for more than 70 years. Recent proposals to eliminate or even to eradicate malaria have led to a renewed interest in mass drug administrations in areas with very high malaria endemicity. Drugs have been administered either directly as a full therapeutic course of treatment or indirectly through the fortification of salt. Mass drug administrations were generally unsuccessful in interrupting transmission but, in some cases, had a marked effect on parasite prevalence and on the incidence of clinical malaria. MDAs are likely to encourage the spread of drug-resistant parasites and so have only a limited role in malaria control. They may have a part to play in the management of epidemics and in the control of malaria in areas ...

Cautions. Use with caution in sick, debilitated or underweight animals and dogs weighing less than 10 lbs. Certain dogs of the collie breed are more sensitive to the effects of ivermectin.Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, and a drug interaction may be anticipated. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. The following drugs can potentially interact with pyrantel pamoate: levamisole, organophosphates, diethylcarbamazine, and piperazine. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.. ...

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Our data reveal a pharmacological drug synergy between registered classes of antibiotics when combined with the standard antifilarial drug ABZ in targeting the filarial symbiont Wolbachia. The impact of this synergy is to reduce treatment time to as little as 1 wk to substantially deplete symbionts with concomitant long-term embryostatic activities, total inhibition of mf production, and accelerated killing of female worms.. Wolbachia populate two major tissues within female filariae, the hypodermal chord syncytium and the germline (47). The latter population is thought to become stably infected via transfer of hypodermal Wolbachia into germline stem cells during development of female gonads within fourth-stage larvae, at 8-11 d postinfection (48). Wolbachia then rapidly divide during oogenesis (35-50 bacteria per egg) (49). Following fertilization of female worms, Wolbachia further divide and spread in zygotes, by asymmetric mitotic segregation, into the embryonic stem cell precursor of the ...

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