TY - JOUR. T1 - Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity. AU - Bae, Jaehoon. AU - Kumazoe, Motofumi. AU - Fujimura, Yoshinori. AU - Tachibana, Hirofumi. PY - 2019/2/1. Y1 - 2019/2/1. N2 - Obesity is a major problem in developed countries and a burden on social health care systems. Several epidemiological studies showed the protective effects of green tea against obesity-related diseases. Cyclic guanosine monophosphate (cGMP) acts as a mediator for the physiological effects of (−)-epigallocatechin-3-O-gallate, the major constituent of green tea. Here, we showed that the level of phosphodiesterase 5, a negative regulator of cGMP, was up-regulated in adipose tissues of high-fat/high-sucrose (HF/HS) diet-fed mice and that this up-regulation was ameliorated by diallyl disulfide (DADS), the major organosulfur in garlic. A green tea extract (GT) and DADS in combination attenuated HF/HS diet-induced adipose increase and triglyceride ...
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Female Gpat1−/− mice have reduced body weight, gonadal fat pad mass, hepatic TAG content, plasma TAG, and secretion of VLDL-TAG (46). GPAT1 deficiency also protects mice against diet-induced hyperlipidemia and hepatic steatosis (87). After high-fat diet feeding for 3 wk, Gpat1−/− mice exhibit 30% lower plasma TAG levels than wild-type mice, and liver TAG and DAG are reduced, with a reciprocal increase in hepatic acyl-CoA content and plasma β-hydroxybutyrate concentration, which is consistent with the role of GPAT1 in hepatic glycerolipid synthesis. Feeding Gpat1−/− mice a high-fat/high-sucrose diet produces similar results, except for the failure to cause reduced plasma TAG levels (47). TAG and acyl-CoA content in skeletal muscle is not altered in Gpat1−/− mice. Hepatic shRNA adenovirus-mediated knockdown of GPAT1 in ob/ob mice also results in reduced hepatic TAG and DAG content (123).. The effect of GPAT1 deficiency in insulin resistance has been studied in two diet-induced ...
Background: Metabolic disorders such as obesity and diabetes can cause dysfunction of endothelial cells (ECs) and vascular rarefaction in adipose tissues. However, the modulatory role of ECs in adipose tissue function is not fully understood. Other than VEGF-VEGFR-mediated angiogenic signaling, little is known about the EC-derived signals in adipose tissue regulation. We previously identified Argonaute 1 (AGO1; a key component of microRNA-induced silencing complex) as a crucial regulator in hypoxia-induced angiogenesis. In this study, we intend to determine the AGO1-mediated EC transcriptome, the functional importance of AGO1-regulated endothelial function in vivo, and the relevance to adipose tissue function and obesity. Methods: We generated and subjected mice with EC-AGO1 deletion (EC-AGO1-KO) and their wild-type littermates (WT) to a fast-food-mimicking, high-fat high-sucrose diet and profiled the metabolic phenotypes. We employed crosslinking immunoprecipitation (iCLIP)- and RNA-sequencing ...
Recent findings suggest the sugar industry has paid high prices over decades to downplay the role of sugar in the obesity epidemic. But lets not sugarcoat the evidence: increasing or decreasing dietary sugar intake corresponds to similar changes in adults body weight. Consumption of sugar-sweetened beverages (SSBs) yields increased weight gain in both children and adults. Still, "targeted marketing" strategies display SSBs as healthy and trendy, and lead to higher consumption by children, minorities, and low-income populations. Public health agencies and officials must combat longstanding industry-spread misinformation to allow communities to navigate healthfully through the food environment.. In September 2016, researchers revealed that the Sugar Association paid scientists in the 1960s to minimize the link between sugar consumption and negative health impacts, alternatively implicating fats and cholesterol. The public health and ethical repercussions of spreading such misinformation are ...
Background: Increasing sugars intakes has been linked to an increased risk of cardiovascular disease such as diabetes, insulin resistance and obesity. When sugars are consumed in excess of energy requirements and glycogen storage capacity they are converted to lipids in the liver and stored as fat. This also results in an increase in circulating lipid concentrations in the blood. The aim of this thesis was to determine whether there is a relationship between consumption of dietary sugars and blood lipids as a biomarker of cardiovascular risk. Design: Systematic review and meta-analysis of randomised controlled trials (RCTs) following the Cochrane Collaboration guidelines including and using Cochrane meta-analysis software Revman 5.0. Data sources: Four article databases (OVID Medline, Scopus, Embase and CINAHL) were searched for randomised controlled trials published before April 2012. Grey literature sources and references lists of review articles were also searched. Study selection: We ...
A mouse study by researchers at Washington University School of Medicine in St. Louis suggests that a pregnant womans high-fat, high-sugar diet may have consequences for later generations. The study indicates that a womans obesity can cause genetic abnormalities that are passed through the female bloodline to at least three subsequent generations, increasing the risk of obesity-related conditions.
How do you know when your blood sugar too high, and what should you do about this situation? The first step that you may want to take is to switch to a low blood sugar diet. This diet helps to keep your blood sugar at a stable level which is more normal, and can prevent many complications associated with elevated blood sugar. If you are prescribed insulin you may be advised to give yourself a shot, but if you are not diabetic there are other things you can do to get these numbers down.. ...
The Best Low Sodium No Sugar Diet Recipes on Yummly | Honey Mustard Salad Dressing, Persian Style Baked Herb Omelet, Mikes Diet Chicken A La Hg
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To prevent chronic diseases such as heart disease, WHO suggests limiting your sugar intake to a maximum of five percent of your daily calories.
An epidemiological study of breast cancer mortality in relation to food consumption, found there is a strong correlation in older women, between breast cancer mortality and sugar consumption. According to this study, the possible link between sugar consumption and breast cancer is insulin. Our bodies supply insulin production in response to our blood glucose level. When this regulatory mechanism is overloaded by large dietary sugar intake, the levels can become excessive. This imbalance may explain the increased risk of mammary cancer in diabetics.. The cells in our bodies need glucose for energy. When healthy cells complete their life cycle, they die off and are replaced with healthy cells. Cancer is developed when old cells continue to grow and divide in one place, creating a tumor.. In 1924, a publication of Dr. Otto Warburgs paper, "On metabolism of tumors." said, "Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a ...
The Food and Drug Administration has finally decided to put a cap on daily sugar intake for Americans. The recommendation will be for a maximum of 10 percent of calories, meaning no more than 12.5 teaspoons of sugar per day.
Ive noticed that this is the time of year (really, it can start around Halloween) that people let their sugar consumption really fly. Ive even been known to eat a bit more of the sweet stuff in various forms simply because its there, too. The problem is that, as a country, we get much more sugar than we need on a regular basis, anyway. The 2010 Dietary Guidelines for Americans recommends that total intake of discretionary calories (that includes added sugars and solid fats) be between 5% and 15%. According to data from the 2005-2010 National Health and Nutrition Examination Survey, about 13% of adults total calories come from added sugar; the 2005-2008 survey reported that about 16% of children and adolescents total calories come from added sugar. At this levels, sugar intake takes up all of our discretionary calories ...
NEW research linking a diet high in sugar and processed foods to brain shrinkage has prompted a rethink on safe blood sugar levels.
If worms are any indication, all the sugar in your diet could spell much more than obesity and type 2 diabetes. Researchers reporting in the November issue of Cell Metabolism, a Cell Press publication, say it might also be taking years off your life. By adding just a small amount of glucose to C. elegans usual fare of straight bacteria, they found the worms lose about 20 percent of their usual life span. They trace the effect to insulin signals, which can block other life-extending molecular players.. Although the findings are in worms, Cynthia Kenyon of the University of California, San Francisco, says there are known to be many similarities between worms and people in the insulin signaling pathways. (As an aside, Kenyon says she read up on low-carb diets and changed her eating habits immediately -- cutting out essentially all starches and desserts -- after making the initial discovery in worms. The discovery was made several years ago, but had not been reported in a peer-reviewed journal until ...
The BBC program Truth about sugar was on the tele this week. Fiona Phillips presented the documentary and delved into where we find sugar and what it does to our bodies.. They followed 4 people who ate high sugar diets, 23-39 tsp of sugar per day. If we calculate how much this is as a percentage of their calorie intake (presuming ladies eat 2000kcals and men 2500kcals - although I would expect these people ate more that this!) then this would be between 20-25% of their calories as sugar, much more than recommended intake. They were told to cut sugar out of their diet, they managed to do this by cutting out sugary drinks and foods and cooking from scratch. They got their sugar intake down to between ¼ - 7 tsp per day. Unsurprisingly 3 out of 4 managed to lose weight and reduced their risk of developing diabetes and non alcohol fatty liver disease, but one man, although cutting his sugar intake down from 29 - 7 tsp per day didnt manage to lose any weight. It turned out that although he had ...
Ive never had blood sugar issues before but I went on a Paleo diet three months ago. Ive lost some weight which is a good thing, but my blood glucose...
How much weight you lose on a particular diet depends in part on the total calories consumed. If you eat large quantities of food, consuming a diet low in...
Researchers at the University of Toronto investigating the amount of free sugar in Canadian prepackaged foods and beverages are calling for new guidelines and better food labeling to help consumers make better choices.
We have been talking about fats and cholesterol and we have pointed to the detrimental effects of sugar consumption. Sugar and fats might not appear to be connected but according to nutrition expert Udo Erasmus, refined dietary sugars and starches almost always turn into fats in the body. In this fat and cholesterol phobia driven…
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The team wrote that sugar is generally perceived as nothing more than empty calories that, when consumed in excess, can lead to obesity. However, the effects of sugar may be far more sinister than this, as studies have shown that it can disrupt hormone signaling and lead to liver damage ...
Most stored body fat is in the form of triglycerides (triacylglycerols), which represent a highly concentrated form of energy. Most dietary fat is also triglycerides. But the body also makes triglycerides in the liver from carbohydrates. And the fastest, surest way … Continue reading →. ...
Sugar is present in almost every food and drink item. It is far from a bad ingredient, but it can be harmful to your health when consumed excessively.
The alarming truth is that Australians are now consuming more sugar than before. Unfortunately, the problem is more prevalent amongst teenagers.
Excess sugar consumption should be considered a form of addiction, an animal study revealed. A team of researchers at the Queensland ...
Last week we discussed the importance of reducing salt intake for a better health and nutrition. This weeks post is about reducing sugar intake. The World Health Organization has recently updated the recommendations on the amount of sugar adults and children should consume every day. The intake of free sugars should be less than 10%…
How much sugar should you eat in a day? Turns out, your daily sugar intake is probably higher than you think-and it could be time to cut back.
Here are some tips that will help you cut sugar intake, which should help improve your overall health, while also aiding your weight loss efforts.
A University of Sydney study has found an alarming three-quarters of one age group exceeding the guidelines for daily sugar intake.
So you are looking for tips on how to reduce sugar intake. Here are a few secrets the health food companies dont want you to know about!
A ground-breaking study from the University of Surrey found that a subject group of otherwise healthy men after they had consumed a high sugar diet had...
It is very important be proactive in terms of our private health and the health of our family. Rigorously detailing the medical history of every member of the family is becoming a more frequent development in households in every single place. In response to some health consultants, sugar not only makes you achieve fats but could cause melancholy and lack of concentration too and that the average person is three.5 stone heavier now than they had been back within the sixties as a result of will increase in sugar intake. It destroys collagen within the pores and skin which means you age quicker. Its highly addictive which means you will crave extra, the more you eat. Sugar is definitely was fats in the body due to the velocity at which it enters the blood stream giving us little chance to burn it off. A direct link exists between sugar consumption, weight gain and weight problems. Thats the reason some governments have thought of placing a tax on foods with excessive sugar content material ...
Dr. Scott Olsons 30-Day Sugar Free Challenge - why high-sugar diets contribute to illness, and details of the program hes devised to help in overcom
high-sugar diet actually reprogrammed how genes function - genes that are closely related to those that help determine the human life span. If thats the
Sugar is everywhere, occurring naturally in food and added to it, too. Get your sugar intake under control by educating yourself about its various names and where youre most likely to find it.
Scientific American has published many articles that describe the link between the gut biome and overall health. Fiber-Famished Gut Microbes Linked to Poor Health and Mental Health May Depend on Creatures in the Gut. The collective genome of our inhabitant commensals is at least 150 times greater than our own genetic material--and most live in our gut. That alone speaks to the power of understanding the interplay between our immune systems and the resident microbes. Data about the prevelance of antibiotics in our food, healthcare systems, as well as high-sugar diets have resulted in a shift in our microbial communities--and not for the better ...
Since this here is going to be a big year regarding my weight which I am very happy about. I thought I would post here. Right now I am on a No carb/No sugar diet. I thought it was going to be hard, it has and it hasnt. I am a chocolate person during that time of the month and not having any, well its amazing my kids are still alive. On Dec. 4th me and my parents went down to Indy for an appt with the doc. She was really nice and we talked over my options. Because I live so far away and have over 150 lbs to live it was decided that I would have the Gastric instead of the Lap-Band. With the Lap-Band I would have to go down to at least once a month for a year. I dont mind going down there but I even thats a little much. So we came home and on Saturday My mom and I took out all the bad stuff that I couldnt eat and the kids wouldnt eat. I gave 4 bags to church and my mom took 3. Yes 7 bags of crap. Then we went right over to to the store and got what I could. In the first week of doing it I ...
How to Identify Added Sugar in Your Food - High sugar intake is associated with obesity, diabetes and cardiovascular disease, among other ailments, and its impact...
Are you a sweet tooth like me? If so, you should be aware that too much sugar consumption can lead to several health problems especially since this substance can be addictive. To ensure your health is not compromised, here are some ways to overcome your sugar addiction.
Sugar consumption has gone up exponentially since the early 1900s and the average American consumes over 160 lbs of added sugars per year.
The data regarding sugar consumption and the increased risk of cancer are not consistent, making it difficult to draw definitive conclusions.
The sugar fructose such as in soda has been linked to a rise in metabolic disease due to a triggering factor that increases glucose production.
Sugar is one of the worst things that you can put in your diet. It can affect both your hormones and your weight. Heres a few reasons why you shouldnt.
On June 21-22, 2017, the Food and Nutrition Board convened A Workshop on Strategies to Limit Sugar-Sweetened Beverage Consumption in Young Children: Evaluation of Federal, State, and Local Policies and Programs, in Washington, DC.
This review evaluates whether there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and its related diseases.
We investigated the consumption of sugar-sweetened beverage (SSB) and its association with obesity and hypertension in a national sample of children and adolescents in China, where many low- and middle-income families live. Data were obtained from a 2014 national intervention program against obesity in Chinese children and adolescents aged 6-17 years. Height, weight, waist circumference, and blood pressure were measured. Information of SSB consumption, socioeconomic status, dietary intake, screen time, and physical activity were self-reported. Multivariate logistic regression was used to assess the association of SSB consumption with obesity and hypertension. A total of 66.6% of the 53,151 participants reported consuming SSB. The per capita and per consumer SSB intake were 2.84 ± 5.26 servings/week and 4.26 ± 5.96 servings/week, respectively. Boys, older children, and adolescents, and individuals with long screen time or high physical activity or low parental education level were more likely to
Background and aims: The prevalence of obesity among children and adolescents is increasing worldwide. One of the key lifestyle behaviors that helps prevent obesity and being overweight among children and adolescents is to avoid drinking sugar-sweetened beverages (SSBs) or to take, at most, one serving per day. The present study intended to evaluate knowledge and perceptions of high school girl students in Shahrekord on reducing SSBs consumption based on the health belief model (HBM). Methods: The present descriptive-analytical study, conducted in 2013-2014, randomly recruited 308 female students aged 13-14 years. The data were collected using a researcher-made questionnaire based on HBM and a food frequency questionnaire (FFQ). The validity and reliability of the questionnaire were evaluated using face validity, content validity, and inter-rater reliability. The Chi-square test, Pearsons correlation, and Spearmans correlation tests were used in SPSS software to analyze the data. The participants