Approach and Results-SR-BI/LDLR double knockout and control LDLR knockout mice were fed atherogenic diets containing different amounts of fat, cholesterol, and sodium cholate. Double knockout mice fed atherogenic diets high in cholesterol exhibited significantly reduced survival compared with LDLR knockout mice fed the same diets. In addition to increased diet-accelerated aortic sinus atherosclerosis, we observed significant diet-induced CA atherosclerosis in double knockout mice and diet-dependent accumulation of platelets in CA atherosclerotic plaques. This was accompanied by substantial myocardial fibrosis in double knockout mice fed high cholesterol diets. Atherogenic diet fed double knockout mice also exhibited higher circulating cytokine levels, monocytosis with increased proportions of Ly6Chi and Ly6Cint monocytes, and higher adhesion molecule expression in CA endothelial cells compared with control LDLR knockout mice.. ...
Background: We previously reported that immunization of apoE−/− mice with human apoB-100 related peptide P210 (KTTKQ SFDLS VKAQY KKNKH) resulted in a 60% reduction in atherosclerosis by a regulatory T-cell (Treg) response elicited by the vaccine. In this study, we investigated the mechanisms involved in this regulatory response.. Methods and Results: Male apoE−/− mice were immunized at 6, 9 and 11 weeks of age with P210 conjugated to cBSA, and alum as adjuvant, at a dose of 0.1 mg/mouse and euthanized at 13 weeks of age, or fed atherogenic diet until euthanasia at 25 weeks of age. At 13 weeks, FACS analysis of regional LN showed significantly reduced CD11c + CD86 + dendritic cells (DC) in the p210 group (Table⇓), suggesting an immune-regulatory response. Treg profiling showed significantly increased CD8 + CD25 + Treg in the peripheral blood (PBMC) of P210 group (Table⇓) without changes in the CD4+CD25+ and CD8+CD28- Treg. CD11c+ DCs in atherosclerotic lesions at 25 weeks were reduced ...
Social environment as a factor in diet-induced atherosclerosis.: Rabbits on a 2 percent cholesterol diet were individually petted, held, talked to, and played w
Increased oxidative stress in obese diabetes may have causal effects on diabetic complications, including dyslipidemia. Lipopolysccharides (LPS) along with an atherogenic diet have been found to increase oxidative stress and insulin resistance. Cranberry has been recognized as having beneficial effects on diseases related to oxidative stress. Therefore, we employed obese diabetic animals treated with an atherogenic diet and LPS, with the aim of examining the effects of cranberry powder (CP) on diabetic related metabolic conditions, including lipid profiles, serum insulin and glucose, and biomarkers of oxidative stress. Forty C57BL/KsJ-db/db mice were divided into the following five groups: normal diet + saline, atherogenic diet + saline, atherogenic diet + LPS, atherogenic diet + 5% CP + LPS, and atherogenic diet + 10% CP + LPS. Consumption of an atherogenic diet resulted in elevation of serum total cholesterol and atherogenic index (AI) and reduction of high density lipoprotein ...
Inbred mouse strains B6 and C3H have been studied extensively as a model of the genetic control of atherogenesis. In response to an atherogenic diet, B6 mice develop fatty streak lesions in the proximal aorta, whereas C3H mice are totally resistant to fatty streak formation. The present study was undertaken to determine the levels (plasma lipids, monocytes, and arterial wall cells) at which genetic variations affect atherogenesis in these 2 mouse strains.. In wild-type mouse models, atherosclerosis is induced by feeding a high-fat, high-cholesterol diet that contains cholate. In response to this diet, strain B6 mice have reduced levels of HDL compared with C3H mice.15 Moreover, this diet results in a reduction in serum paraoxonase, an HDL-associated enzyme that protects against LDL oxidation, in B6 mice but not in C3H mice.16 The apoE−/− mice represent a mouse model in which spontaneous hyperlipidemia and atherosclerosis occur with a low-fat, low-cholesterol diet.24 25 In the present study, ...
The first murine model to support the concept that hyperglycemia accelerated atherosclerosis tested the hypothesis that induction of diabetes using multiple low-dose streptozotocin would result in enhanced atherosclerosis in mice fed Western-type diet.25 In these first studies, wild-type BALB/c and C57BL/6 mice were used. In these animals, genetic manipulation was not used as a means to trigger/enhance the development of atherosclerosis. Rather, dietary modification induced hyperlipidemia. In this study, Kunjathoor et al showed that BALB/c mice fed an atherogenic diet and rendered diabetic with streptozotocin displayed a 17-fold increase in atherosclerotic lesion area compared with citrate-treated (nondiabetic) mice fed the same atherogenic diet. Although the lesions were limited to fatty streaks, histological studies nevertheless revealed the presence of both excess mononuclear phagocytes and smooth muscle cells in the plaques.25 Interestingly, these investigators found that there were no ...
Ten inbred strains of mice were fed an atherogenic diet containing 1.25% cholesterol, 0.5% cholic acid and 15% fat. The strains were examined for plasma cholesterol and triglyceride levels and for formation of lipid-containing lesions in the aortic wall. The strains differed considerably in the frequency of lesion formation after 14 weeks on the atherogenic diet with a range of 0-1.8 lesions/mouse. The order of susceptibility to lesion formation from the least susceptible to the most susceptible was BALB/cJ, C3H/J, A/J, SWR/J, NZB/J, less than 129/J, AKR/J, DBA/2J, less than C57L/J less than C57BL/6J. Total plasma cholesterol after 5 weeks on the diet varied from 131 mg/dl to 328 mg/dl among strains; however, there was little correlation between total cholesterol levels and susceptibility to lesion formation (r = 0.29). Plasma triglycerides after 5 weeks on the diet varied less than cholesterol with a range of 137-220 mg/dl. An analysis of the genetic differences among inbred strains of mice
CYP7A1 encodes the rate limiting enzyme for the conversion of cholesterol to bile acids. Several studies have demonstrated that elevated expression of CYP7A1 confers protection from hypercholesterolemia. CYP7A1 expression is regulated by two nuclear receptors, farnesoid X receptor (FXR) and small heterodimer (SHP). Here we demonstrate that although FXR−/ − and SHP−/ − mice have similarly elevated levels of CYP7A1, FXR−/ − mice have elevated serum cholesterol and triglyceride levels and serum markers of hepatic inflammation whereas the SHP−/ − mice do not. This suggestion of a beneficial lipid effect of the loss of SHP was confirmed in a cholesterol/cholic acid diet model, in which SHP−/ − mice were strongly protected form diet-induced hypercholesterolemia and hepatic inflammation. To examine the effects of the loss of SHP in a model relevant to human dyslipidemia, we generated LDLR−/ −SHP−/ − mice. The LDLR−/ −SHP−/ − mice were highly resistant to Western ...
MyJournals.org - Science - [ASAP] Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells (Journal of Agricultural and Food Chemistry)
Semantic Scholar extracted view of [Effect of pancreatic lipase on the development of experimental atherosclerosis]. by I. P. Bondarenko
Rabbits on a 2 percent cholesterol diet were individually petted, held, talked to, and played with on a regular basis. Measurements of aortic affinity for a Sudan stain, serum cholesterol levels, heart rate, and blood pressure were made at the end of the experimental period. Compared to control groups, which were given the same diet and normal laboratory animal care, the experimental groups showed more than a 60 percent reduction in the percentage of aortic surface area exhibiting sudanophilic lesions, even though serum cholesterol levels, heart rate, and blood pressure were comparable. ...
Cardiovascular diseases are the main cause of death in the United States. Most of treatments that are currently used are low-fat diet (LFD) and statins. However, alternatives have been proposed such as low-carbohydrate diets (LCD) and other drug treatments such as the use of inhibitors of secretory phospholipase A2 (i-sPLA2). Thus, in order to test whether they are an adequate alternative, two guinea pig studies were conducted. ^ The first study evaluated the effect of an i-sPLA2 on the prevention of atherosclerosis. The association of elevated levels of sPLA 2 in patients with cardiovascular diseases and their presence in atherosclerotic lesions suggest the participation of sPLA2 in this disease. Twenty-four guinea pigs were fed an atherogenic diet for twelve weeks. Half of them were treated with A-002, the i-sPLA2. The other animals were used as control. There was no difference on plasma lipids between groups, however, there was less inflammation (p|0.05) in aorta from the i-sPLA2 group. This group
Serum A FABP was reported to JNJ-7706621 443797-96-4 become reduced with statin treatment, but improved with the therapy of thiazolidinedione. Regardless of va
One of the best ways to treat or prevent atherosclerosis is through changes to what you eat. We take a look at some of the best tips for creating a heart-healthy diet plan.
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Atherosclerosis was produced in dogs by feeding them thiouracil and cholesterol. The increments in cholesterol concentration at sites along the length of the aortas of these dogs Avere determined by subtracting from the value for each site the corresponding value obtained from normal dogs. After about 1 month on the experimental regimen the cholesterol increments along the length of the aorta formed a gradient. The increment was greatest in the proximal aorta and progressively less down the length of the aorta. After about 5 months on the regimen, the gradient no longer existed. Instead, the cholesterol increment in the abdominal aorta exceeded that in the thoracic aorta. Albumin is known to enter aortic wall with a gradient of rates that is similar to the gradient of cholesterol increments early in the course of experimental atherosclerosis.. The foregoing facts are consistent with the following theory: In the development of atherosclerosis, intact low-density lipoproteins containing ...
Result: Data of this study have showed that atherogenic diet caused an increase in serum level of TC, LDL, VLDL and TG and a decrease in serum level of HDL. Treatment of rabbits with irbesartan caused substantial decrease in serum lipid profile compared with untreated rabbit receiving atherogenic diet. No significant difference was seen between irbesartan- and rosuvastatin-treated rabbits in all lipid parameters measured with the exception that the HDL level in rosuvastatin-treated rabbits was significantly higher than that of irbesartan-treated rabbits. Rabbit treated with irbesartan showed a significant decrease in the serum level of high sensitive C-reactive protein, ICAM1, VCAM1 and aortic total antioxidant capacity when compared with untreated group. No significant difference was seen between irbesartan- and rosuvastatin-treated rabbits in all these inflammatory parameters measured. Histopathological examination showed that irbesartan decreased atherogenic lesion significantly when compared ...
WOMEN -- Health & hygiene. Abstract:Discusses research being done on the association between fish intake and the progression of coronary artery atherosclerosis in women with coronary artery disease. Reference to a study by A. T. Erkkila, A. H. Lichtenstein, D. Mozaffarian, D. M. Herrington, published in a 2004 issue of the "American Journal of Clinical Nutrition"; Method used to evaluate changes in the mean minimum coronary artery diameter, the mean percentage of stenosis and the development of new coronary lesions; Food servings with which smaller increases in the percentage of stenosis was associated.. ...
Causes and diagnosis of medical symptom Abdominal aortic atherosclerosis with references to diagnosis, testing, and other symptoms.
eview article describes the imaging modalities contributing to the diagnosis of aortic atherosclerosis. All imaging modalities do contribute to diagnostic imaging; however only echo provides realtime imaging during the different phases of treatment. If conventional TEE imaging quality is insufficient, additional screening with modified TEE or epiaortic ultrasound is advised. Modified TEE with A-View has the advantage to be performed before surigcal incision, when changes in surgical management or a crossover to a nonsurgical management can still be considered.. Click on the picture to read the article.. ...
Atherosclerosis can affect the heart, kidneys, and virtually any other organ. Learn more about atherosclerosis in this article from Discovery Health.
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human homocysteine-thiolactonase: detoxifies homocysteine-thiolactone in blood and could thus delay the development of atherosclerosis
The natural variation among inbred strains of mice was used to elucidate the genetic factors underlying the responsiveness to high-fat and high-cholesterol diets. The nine strains examined are the progenitors of recombinant inbred strain sets: C57BL/6J, C57L/J, SWR/J, SJL/J, SM/J, A/J, AKR/J, C3H/HeJ, and DBA/2J. Plasma lipids, liver lipids, the prevalence of cholesterol gallstones, and the size of aortic fatty streak lesions were examined after 18 wk of consumption of the diet containing 15% fat and 1% cholesterol. The variation in aortic lesions found among inbred strains provided the basis for several additional studies that demonstrated the existence of eight genes affecting atherosclerosis. These genes, named Ath1 to Ath8, are briefly described. The genetic analysis of variation in gallstone formation demonstrated that more than one gene affects this phenotype.
Issuu is a digital publishing platform that makes it simple to publish magazines, catalogs, newspapers, books, and more online. Easily share your publications and get them in front of Issuus millions of monthly readers. Title: What Are The Best Ingredients In High Cholesterol Diet Recipes.txt, Author: Carl Peterson, Name: What Are The Best Ingredients In High Cholesterol Diet Recipes.txt, Length: 2 pages, Page: 1, Published: 2012-05-31
L-arginine is the substrate of nitric oxide production which is involved in the regulation of apoptosis and inflammatory processes. The effect of L-arginine after the formation of fatty streaks (FS) is not fully understood in the hypercholesterolemic model and therefore the main objective of this study was to investigate the effect of L-arginine after fatty streaks were developed in the rabbit aorta. Eighteen male rabbits were fed a 1% cholesterol diet for four weeks. One third of the animals were sacrificed randomly to verify fatty streak formation in the aorta (phase I). Then the high cholesterol diet was replaced with a normal diet, and the remaining animals (n=12) were divided into two groups (phase II); group 1 (n=6): normal diet and group 2 (n=6): normal diet plus L-arginine (3% in drinking water). The experiment was continued for a further four weeks. The serum levels of lipids and lipoproteins were increased significantly in phase I ( ...
The endothelial permeability of aorta (EPA) is influenced by atherosclerosis. Whether the physiological difference in EPA is a sex-dependent phenomenon remains to be determined. The objective of this study was to determine the EPA difference between male and female rabbits. An experimental model was designed to obtain 4 groups of animals. The ovariectomized rabbits were fed with normal (group I) and 1% cholesterol-rich diets (group III). The male rabbits also received normal (group II) and cholesterol-rich diets (group IV). After 5 wks, the EPA was measured by Evan Blue (EB) dye uptake method. The EB uptake was significantly (p|0.05) lower in females, regardless of the diet they used. In groups I to IV, the mean±SD EB uptake was 4.83±2.06, 15.15±2.91, 7.01±2.40, and 20.58±3.62 mg/g weight of aorta, respectively. The lower EPA in females may play a role in reducing the risk of development of atherosclerosis.
Original paper-INFLUENCE VARIATION OF TEMPE GEMBUS (AN INDONESIAN FERMENTED FOOD) ON HOMOCYSTEINE AND MALONDIALDEHYDE OF RATS FED AN ATHEROGENIC DIET
Starting a high cholesterol diet may seem incredibly easy. After all, it is just adding in a bowl of oatmeal and a handful of nuts a day, right? Wrong.
Foods to avoid if a person is on a no cholesterol diet are animal products such as meat, dairy, poultry and some fish, according to WebMD. Therefore, a no cholesterol diet is basically a vegetarian...
I would like to note] that back in [August] 2000, we published a paper in Neurobiology of Disease (Refolo et al., 2000) demonstrating for the first time that cholesterol metabolism accelerates β-amyloid accumulation in a transgenic mouse model of AD. We show that diet-induced hypercholesterolemia alters APP processing in a manner giving rise to more A-β. What Beyreuther did was in cell lines. Our work used one of the best animals models for AD available.. ...
This webinar is Part 2 of the Webinar hosted by Dr. Walker III. Dr. Walker continues the discussion on a novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis.
Cholesterol in food doesnt necessarily raise cholesterol levels in your blood. Translation: High-cholesterol foods like eggs can be healthy.
Diet for high colestorol - High Cholesterol Diet Plan, Meal Plans & High Cholesterol .... Dietrine Carb Blocker is an exclusive formulation of research-supported botanical ingredients designed to Block Carbohydrates, Control Carb Cravings, Boost Energy levels and Block Fats from your body.
Bayer and Johnson &Johnsons blockbuster clot prevention drug Xarelto wasshown to cut the risk of potentially deadly strokes and heartattacks in patients with severe atherosclerosis by 24 percent,raising the prospects of billions more in sales.
Doctors Ask: Compliance with a strict diet in atherosclerosis is a major component of treatment. Atherosclerosis is one of the diseases in which observance of a particular diet is a key point in the treatment process. The goal of such a balanced diet is to minimize the amount of products that contain a huge amount of cholesterol and fats of animal origin.
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Smoking Causes Atherosclerosis on Stop Smoking Tips | Smoking is one of the major causes of atherosclerosis which is a disease where plaque builds up inside…
Definícia pre hľadané cudzie slovo atherosclerosis - ateroskleróza, kôrnatenie tepien, hromadenie tukových a väzivových plátov v cievnej stene s následným zúžením priesvitu artérie... Definícia pre hľadané cudzie slovo atherosclerosis - pozri...
Our site will help you find more information about the main causes of atherosclerosis. The list of such causes is pretty long and includes smoking, obesity, etc.
If you want to know more about the heart disease called atherosclerosis, then visit this website. Here you can find detailed information about this condition
Free Online Library: Chlamydialike organisms and atherosclerosis.(Letter to the editor) by Emerging Infectious Diseases; Health, general
Roman C, Gooch A, Maranhao V. Far-advanced coronary artery atherosclerosis in a 25-year-old man. J Am Osteopath Assoc 1986;86(8):496. doi: https://doi.org/10.7556/jaoa.1986.86.8.496.. Download citation file:. ...
The theory that iron may play a significant role in atherogenesis by promoting the formation of free radicals is controversial. Previous results using the new technique of nuclear microscopy showed a seven-fold increase in iron concentrations within newly formed atherosclerotic lesions in hypercholesterolemic rabbits compared to healthy artery tissue. In a follow- up time sequence study described here, we show that iron accumulation occurs at the onset of lesion formation. In addition, weekly bleeding decreases the iron uptake into the artery wall and delays the onset of atherogenesis. These results provide direct evidence for a key role of iron in initiating atherogenesis ...
Our study shows that (1) CD8+ T‐cell activation and memory generation occurs in response to atherogenic diet feeding in apoE−/− mice; (2) A small fraction of these activated CD8+ T cells in apoE−/− mice are antigen‐specific that are reactive to the p210 peptide fragment of apoB‐100, supporting the notion that p210 is a self‐antigen; and (3) Immunization of apoE−/− mice with the p210 peptide fragment altered the immune‐dominant epitopes, concurrent with reduced atherosclerosis. This has significant implications in our efforts to characterize immune functions in atherosclerosis and develop potential apoB‐100 peptide‐based vaccine candidates.4, 22. T‐cell activation is a hallmark feature of adaptive immunity. Naïve T cells undergo activation and clonal expansion of antigen‐specific T cells when encountering antigen presented by antigen‐presenting cells in the context of costimulatory signaling. Such antigen‐specific T cells further differentiate into effector and ...
The official name of this trial was "Testosterones Effects on Atherosclerosis Progression in Aging Men," TEAAM for short. The researchers first recruited 308 male subjects from across the United States aged 60 or older. Then they were split into two groups, and over the course of three years, TEAAM closely followed half of the male subjects who had unknowingly received placebos, and the other half who had received testosterone gel treatment. The careful design of the research combined with the length of time and the scope of the project make this trail more authoritative than previous studies. To the knowledge of the researchers, this was the largest "randomized trial investigating testosterones effects on atherosclerosis progression in older men to date." The trial was "significantly long to determine clinically meaningful effects" of the treatment on the build-up of plaque on the artery walls. ...
In this community-based study of middle-aged white men, heavy consumption of alcoholic beverages was significantly associated with a higher aortic cal...
DAMASCENO, Nágila Raquel Teixeira; APOLINÁRIO, Elaine; FLAUZINO, Fabiana D.; FERNANDES, Irene; ABDALLA, Dulcinéia Saes Parra. Soy isoflavones reduce electronegative low-density lipoprotein (LDL-) and anti-LDL- autoantibodies in experimental atherosclerosis. European Journal of Nutrition, Darmstadt, v. 46, n. 3, p. 125-132, 2007. DOI: 10.1007/s00394-006-0640-9 ...
A finding from the University of Virginia overturning assumptions about the biology of atherosclerotic plaques could prompt companies to rethink their therapeutic strategies for the disease.