TY - JOUR. T1 - Role of glucocorticoid receptor and CCAAT/enhancer-binding protein α in the feed-forward induction of 11β-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts. AU - Yang, Zhen. AU - Guo, Chunming. AU - Zhu, Ping. AU - Li, Wenjiao. AU - Myatt, Leslie. AU - Sun, Kang. PY - 2007/11/1. Y1 - 2007/11/1. N2 - The amount of cortisol available to its receptors is increased by the pre-receptor enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) which converts cortisone to cortisol. We examined the molecular mechanisms of the feedback effect of cortisol on 11β-HSD1 mRNA expression in human amnion fibroblasts. Our data showed that cortisol-induced 11β-HSD1 mRNA expression dose dependently in amnion fibroblasts, which could be completely blocked both by the mRNA transcription inhibitor 5,6-dichlorobenzimidazole riboside and by the glucocorticoid receptor (GR) antagonist RU486, and partially blocked by global inhibition of CCAAT/enhancer-binding ...

We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA polymerase II (Pol II) in conjunction with the transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB). This factor, termed DRB sensitivity-inducing factor (DSIF), is also required for transcription inhibition by H8. DSIF has been purified and is composed of 160-kD (p160) and 14-kD (p14) subunits. Isolation of a cDNA encoding DSIF p160 shows it to be a homolog of the Saccharomyces cerevisiae transcription factor Spt5. Recombinant Supt4h protein, the human homolog of yeast Spt4, is functionally equivalent to DSIF p14, indicating that DSIF is composed of the human homologs of Spt4 and Spt5. In addition to its negative role in elongation, DSIF is able to stimulate the rate of elongation by RNA Pol II in a reaction containing limiting concentrations of ribonucleoside triphosphates. A role for DSIF in transcription elongation is further supported by the ...

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DRB-treated HeLa cells stably expressing BAC-encoded GFP-labeled snRNP protein U1-70K and imaged witb a PicoQuant MicroTime 200 confocal microscope us...

The solvate structure of 3,4-dichloro-1-nitro-benzene with 1,4-dioxane, C6H3Cl2NO2·0.25C4H8N2, is reported. The asymmetric unit comprises two independent 3,4-dichloro-1-nitro-benzene mol-ecules and half of a 1,4-dioxane mol-ecule, the solvent molecule being disposed about a centre of inversion. Double chains of 3,4-dichloro-1-nitro-benzene are linked by ClCl inter-actions and 1,4-dioxane mol-ecules via C - HO hydrogen bonds into a two-dimensional sheet.. ...

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Thymidine, a pyrimidine deoxynucleoside, is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication. - Mechanism of Action & Protocol.

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Name: 2,6-Dichioro-4-nitroaniline CA Name: Benzenamine,2,6-dichloro-4-nitro- Molecular Structure: 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 Molecular Formula:C6H4Cl2N2O2 Molecular Weight: 207.00 CAS Registry Number: 99-30-9

To search by structure, left click in the box below to display the chemdraw toolbar. Then, draw the chemical structure of interest in the box using the toolbar. When your structure is complete, click Search by Name or Search by SMILES to generate the product name or SMILES respectively. This feature will search within the Gelest product database for matching chemical names or SMILES. Note: In cases where Gelest uses alternate chemical names, it may be necessary to search for the product of interest by its CAS#.. ...

Goats Water is a small accessible tarn in the English Lake District, located between Dow Crag and The Old Man of Coniston to the Duddon Valley, near the town of Coniston. UK Ordnance Survey ...

The biochemical processes of DNA repair, replication and recombination compete for the same substrate, the DNA molecule. This competition is natural, as each process requires the same template. In order to resolve possible conflicts between these processes, when they take place on a particular stretch of DNA, certain crosstalk is expected. The complexity is additionally increased by the existence of another DNA dependent process, which occurs in all phases of the cell cycle: transcription.. This thesis aims to investigate the link between transcription inhibition and homologous recombination, especially in the context of UV-induced DNA damage. The results show that the transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) induces homologous recombination. The DNA damage caused by UVC irradiation is repaired mainly via nucleotide excision repair, however, it is also known to trigger recombinational repair. In the presence of UV-induced damage, transcription inhibition by ...

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Bleomycin sulfate is a mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus.

The explosive properties of 1,2-dichloro-1-fluoro-2-trifluoromethoxy-ethene were evaluated according to the procedure described in the REACH Guidance on Information Requirements and Chemical Safety Assessment - Chapter R7a where a set of criteria is described to identify materials being potential explosives. The first step of the screening procedure is to examine the chemical structure and check for the presence of groups associated with explosive properties. 1,2-dichloro-1-fluoro-2-trifluoromethoxy-ethene does not contain functional groups and elements that are known to confer explosive properties. The appraisal of the molecular structure indicates no risk of rapid decomposition. Thus no other steps of the screening procedure are required and it can be concluded beyond a reasonable doubt that the substance 1,2-dichloro-1-fluoro-2-trifluoromethoxy-ethene does not possess explosive properties. ...

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2,4-dichlorotrifluoromethylbenzene; 2,4-dichlorbenzotrifluorid; 2,4,5-trimethylthieno[2,3-d]pyrimidine-6-carboxylic acid; 2,4-dcbtf; 2,4-dichloro-1-(trifluoromethyl)benzene; 2,4-dichlorobenzotri; 2,4-dichloro-trifluoromethyl; 1,3-dichloro-4-trifluoromethylbenzene; 2,4-dichloro-1-trifluoromethyl-benzene; 1,3-dichloro-4-(trifluoromethyl)benzene; 2,4-dichloro-α,α,α-trifluorotoluene; 4-dichlorobenzotrifluoride ...

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Benzene, [(1E)-3,3-dichloro-1-propenyl]- | C9H8Cl2 | CID 575540 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

This page contains information on the chemical 1,2-Dichloro-1,1,2,3,3-Pentafluoropropane(Hcfc-225bb) including: 2 synonyms/identifiers.

(1-methylindol-5-yl)(2,3-dichloro-4-(((4-carboxypiperidin-1-yl)carbonyl)ethenyl)phenyl)sulfide: an LFA-1 and ICAM-1 antagonist; structure in first source

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The Positive Transcription Elongation Factor b (P-TEFb) is a complex of Cyclin Dependent Kinase 9 (CDK9) with either cyclins T1, T2 or K. The complex phosphorylates the C-Terminal Domain of RNA polymerase II (RNAPII) and negative elongation factors, stimulating productive elongation by RNAPII, which is paused after initiation. P-TEFb is recruited downstream of the promoters of many genes, including primary response genes, upon certain stimuli. Flavopiridol (FVP) is a potent pharmacological inhibitor of CDK9 and has been used extensively in cells as a means to inhibit CDK9 activity. Inhibition of P-TEFb complexes has potential therapeutic applications. It has been shown that Lipopolysaccharide (LPS) stimulates the recruitment of P-TEFb to Primary Response Genes (PRGs) and proposed that P-TEFb activity is required for their expression, as the CDK9 inhibitor DRB prevents localization of RNAPII in the body of these genes. We have previously determined the effects of FVP in global gene expression in a

Actinomycin G (ActD), a good known transcription inhibitors, offers been widely reported to induce cell apoptosis in several types of growth cells by inhibiting the anti-apoptotic gene transcriptions. cell routine police arrest and apoptosis consequently. The present research possess exposed a book system by which ActD prevents osteosarcoma cell proliferations and induce apoptosis, and will offer an useful idea to chemotherapy in long term treatment of osteosarcoma. s using ANOVA testing for evaluations. The worth 0.05 (*), 0.01 (**) and 0.001 (***) was assumed as the level of significance for the figure testing carried out. Outcomes Actinomycin G prevents expansion of MG63 human being osteosarcoma cells Actinomycin G (ActD) can be reported to create anti-cancer activity by joining to guanine residues and suppressing DNA-dependent RNA polymerase [23]. Nevertheless, the toxic effects of ActD on osteosarcoma cells are not elucidated fully. To define the anti-cancer activity of ActD on osteosarcoma ...

11. A process for producing 2,3,3,3-tetrafluoropropene, which comprises: a hydrogenation step of reacting 1,1-dichloro-2,3,3,3-tetrafluoropropene with hydrogen in the presence of a catalyst to produce 2,3,3,3-tetrafluoropropene, which is separated from the reaction product, and to obtain a mixture-comprising unreacted 1,1-dichloro-2,3,3,3-tetrafluoropropene, 1-chloro-2,3,3,3-tetrafluoropropene as an intermediate product and 1-chloro-2,3,3,3-tetrafluoropropane as a by-product; a mixing step of mixing dichloropentafluoropropane including 1,1-dichloro-2,2,3,3,3-pentafluoropropane and at least one of its-isomers, and the mixture obtained in the above hydrogenation step to obtain a raw material composition comprising 1,1-dichloro-2,2,3,3,3-pentafluoropropane and 1-chloro-2,3,3,3-tetrafluoropropane, and a dehydrohalogenation step of contacting the raw material composition with an alkali aqueous solution in the presence of a phase-transfer catalyst to produce 1,1-dichloro-2,3,3,3-tetrafluoropropene ...

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The report generally describes 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole, examines its uses, production methods, patents. 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

Complete information for NELFA gene (Protein Coding), Negative Elongation Factor Complex Member A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

You are viewing an interactive 3D depiction of the molecule 4,6-dichloro-3-[(e)-(2-oxo-1-phenyl-3-pyrrolidinylidene)methyl]-1h-indole-2-carboxylic acid (C20H14Cl2N2O3) from the PQR.

Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.

Expression of RAPGEF3 (bcm910, cAMP-GEFI, EPAC) in breast tissue. Antibody staining with HPA040365, HPA043518 and CAB004386 in immunohistochemistry.

The existence of two waxy alleles, wx a associated with no detectable granule bound starch synthase (GBSS) and wx b associated… Expand ...

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