The dicarboxylate carrier is an important member of the mitochondrial carrier family, which catalyzes an electroneutral exchange across the inner mitochondrial membrane of dicarboxylates for inorganic phosphate and certain sulfur-containing compounds. Screening of the Drosophila melanogaster genome revealed the presence of a mitochondrial carrier subfamily constituted by four potential homologs of mammalian and yeast mitochondrial dicarboxylate carriers designated as DmDic1p, DmDic2p, DmDic3p, and DmDic4p. In this paper, we report that DmDIC1 is broadly expressed at comparable levels in all development stages investigated whereas DmDIC3 and DmDIC4 are expressed only in the pupal stage, no transcripts are detectable for DmDIC2. All expressed proteins are localized in mitochondria. The transport activity of DmDic1-3-4 proteins has been investigated by reconstitution of recombinant purified protein into liposomes. DmDic1p is a typical dicarboxylate carrier showing similar substrate specificity and ...
Slc13a2 (untagged) - Mouse solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 (Slc13a2), (10ug), 10 µg.
Purpose: : Mutations of the pituitary homeobox 2 (PITX2) transcription factor result in Axenfeld-Rieger Syndrome (ARS) and glaucoma. The identification of direct targets of PITX2 is necessary to understand the genetic mechanisms underlying ocular development and disorders including glaucoma. Here, we have identified and characterized the Solute carrier family 13 sodium-dependent dicarboxylate transporter member 3 (SLC13A3) as a potential gene directly regulated by PITX2. Methods: : A hormone-inducible PITX2 expression system was generated to identify genes directly regulated by PITX2. RNA from non-pigmented ciliary epithelial (NPCE) cells transfected with hormone-inducible PITX2, or a negative control, was subjected to microarray analyses using Affymetrix U133A arrays. Data were analyzed using dCHIP algorithms to detect significant differences in expression. Genes with significantly altered expression in multiple microarray experiments in the presence of PITX2 were subjected to in silico and ...
Rhizobium meliloti transports succinate, fumarate, malate, and aspartate by means of the dicarboxylate transport system, which is encoded by dct genes located on the exo megaplasmid. Analysis of these genes using Tn5 insertion mutagenesis revealed three complementation groups within a 5.9-kb HindIII …
Full-length cDNA gene of sodium-dependent dicarboxylate co-transporter protein 1 (SDCT1) is cloned from normal human kidney tissue and inserted into EGFP (enhanced green fluorescent protein)...
2.A.47 The Divalent Anion:Na+ Symporter (DASS) Family. Functionally characterized proteins of the DASS family (also called the SLC13 family) transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. These proteins are found in Gram-negative bacteria, cyanobacteria, archaea, plant chloroplasts, yeast and animals. They vary in size from 432 amino acyl residues (M. jannaschii) to 923 residues (Saccharomyces cerevisiae). The three S. cerevisiae proteins are large (881-923 residues); the animal proteins are substantially smaller (539-616 residues), and the bacterial proteins are still smaller (461-612 residues). They exhibit 11-14 putative transmembrane α-helical spanners (TMSs). An 11 TMS model for the animal NaDC-1 and hNaSi-1 carriers has been proposed (Li and Pajor, 2003; Pajor, 1999). Two serine residues in the human sulfate transporter, hNaSi-1 (Q9BZW2), one in TMS 5 and one in TMS 6, are required for sulfate ...
chemBlink provides information about CAS # 115118-68-8, Diisopropyl 3,3-Dimethoxycyclobutane-1,1-dicarboxylate, Dipropan-2-yl 3,3-dimethoxycyclobutane-1,1-dicarboxylate, molecular formula: C14H24O6.
The fact that four of the nine acid-inducible genes in the gadA region encode transcription factors suggests that the AR genes are subject to complex regulation. We previously identified a conserved 20-bp sequence element upstream of gadA, gadB, and hdeA (25). This 20-bp sequence was recently shown to function in pH control of transcription (8). We and others have suggested that this 20-bp sequence might be the target of binding by the transcription factor YhiX (8, 25). In fact, overexpression of YhiX causes elevated expression of gadA, gadB, and hdeD, suggesting that YhiX is an activator of these genes (20, 23). Future work planned in this laboratory will shed light on regulation by YhiX. However, it is important not to ignore other regulatory genes in the gadA region during studies of acid regulation (e.g., yhiW, yhiF, and yhiE). yhiF is thought to encode a regulator of dctA, a gene involved in dicarboxylate transport (7). The effects of the yhiE mutation and its overexpression, described ...
Learn more about dimethyl-2s-4r-piperidine-2-4-dicarboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
diisopropyl 3-methyl-1H-pyrrole-2,4-dicarboxylate - chemical structural formula, chemical names, chemical properties, synthesis references
Our baby carriers signature padded shoulder straps and waistband ensure the most comfortable ride for parent and baby. Discover the best in baby carriers. | Infant Insert: No Infant Insert Needed, No Infant Insert Needed
The Indy Acetate Earrings by Kitsense are part of the Acetate Collection 0.3. The Indy earrings are available in three colourways and are a delicate hoop style featuring an ombre colour change Details Available in Bubblegum/Mist, Milk/Coffee and Tortoiseshell/Midnight colour ways Acrylic Resin Designed for pierced ear
Transport of dicarboxylates across the plasma membrane is mediated by the Na+/dicarboxylate cotransporters (NaDCs) belonging to the SLC13 gene family. These transporters play important roles in the homeostasis of ...
HEMTEY #JRNL 035,59,2787,1994 #AUTHOR R.Gleiter, B.Treptow, H.Irngartinger, T.Oeser #QUAL at 243 deg.K #PROPS Color: colorless. #SYSCAT sys O cat 3 #CELL a 15.284,2 b 14.882,2 c 7.805,1 z 4 sg Pnma v 1775. cent 1 #DENSITY dx 1.24 fw 330.4 #RFACT R= 0.054 #COMPND Dimethyl hexacyclo(9.5.0.0$1,3!.0$2,10!.0$3,9!.0$9,11!)hexadeca 2,10-dicarboxylate #SYNONM Dimethyl propella(3)prismane dicarboxylate #FORMUL C20 H26 O4 #ATOM O1 0.8519,1 0.4546,1 0.0761,2 O2 0.7778,1 0.3475,1 -0.0662,2 C1 0.8856,1 0.3022,1 0.1253,3 C2 0.9865,1 0.3024,1 0.1573,3 C3 0.9251,1 0.3025,1 0.3078,3 C4 0.9150,1 0.3661,1 0.4540,3 C5 0.9732,2 0.3380,2 0.6058,3 C6 0.9476,3 0.2500 0.6921,5 C7 1.0560,1 0.3662,2 0.1005,3 C8 1.1455,1 0.3382,2 0.1703,4 C9 1.1831,2 0.2500 0.0997,6 C10 0.8376,1 0.3760,1 0.0449,3 C11 0.7316,2 0.4181,2 -0.1575,4 #BOND O1 C10 1.214,3 C2 C3 1.504,3 O2 C10 1.329,3 C2 C7 1.492,3 O2 C11 1.453,3 C3 C3* 1.562,3 C1 C10 1.462,3 C3 C4 1.491,3 C1 C1* 1.554,3 C4 C5 1.539,4 C1 C2 1.562,3 C5 C6 1.525,3 C1 C3 1.548,3 C7 ...
Description. A running, complete example of the fastest Indy Champ cars ever produced. This Lola was raced by Randy Lewis, sponsered by Toshiba/Oracle in the Indy 500, qualifying in 11th place and finishing 16th in 1988. The car comes complete with tons of usable spares, and includes all equipment required to run the car ...
This is tonights best bet for Ducati owners. Its not far from Ducati Indy and the Drury Ducati basecamp hotel. Its supported by the Indy Desmo Ducati Owners Club. | Desmopro News
Best suited for: Know-it-all Yankee visitors who need the theres-no-decent-pie-in-this-burg smirk wiped off their faces, or well-mannered Southerners ready to have their pizza worlds rocked
Laboratory grade Dimethyl 4-(3-chloro-4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate - N/A from Georganics for your specific research needs. Check more product details and SDS.
You are viewing an interactive 3D depiction of the molecule diethyl 8,8-bis{[(methylsulfonyl)oxy]methyl}dispiro[3.1.3.1]decane-1,2-dicarboxylate (C20H20O10S2) from the PQR.
A - Tilt: 4° - Segments: 1( 20- 38), 2( 47- 61), 3( 66- 80), 4( 95- 110), 5( 186- 196), 6( 200- 210), 7( 214- 235), 8( 261- 282), 9( 291- 306), 10( 315- 336), 11( 356- 375), 12( 376- 391), 13( 400- 413), 14( 439- 460 ...
MetabolismTransport and binding proteinsCations and iron carrying compoundstransporter, divalent anion:Na+ symporter (DASS) family (TIGR00785; HMM-score: 432.9) ...
MetabolismTransport and binding proteinsCations and iron carrying compoundstransporter, divalent anion:Na+ symporter (DASS) family (TIGR00785; HMM-score: 293.9) ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
In the dead of winter, Winona, a successful musician looking to relax and find creative inspiration, returns to her hometown to stay in a cabin...
NHRA is hemorrhaging star power. Corporate belt tightening and reduced purses at limited-spectator events is only part of the story.
Indy Backpackers has some of the best guides and leaders in the Midwest and Near South. Our club serves as a forum for them to find some of the best backpacking adventures and for our members to at
SAO PAULO, Apr. 27, 2012: Will Power gave Team Penske its fourth consecutive pole of the season, and the driver of the No. 12 Verizon car set an event qualifying record in the process. Power posted a lap of 1 minute, 21.4045 seconds with about 3 minutes left in the Firestone Fast Six shootout to claim his second consecutive pole start for the Itaipava São Paulo Indy 300 presented by Nestle. It was the 26th pole of his Indy car career, tying Dario Franchitti for ninth overall.
Once upon a time, when a famous and successful moviemaker was discovered working in TV, it meant only one thing: a career on the rocks.That is no longer the case. Witness the increasing number of
Oh, Jen. Hes so photogenic. I just love all of them. Somehow I had missed the update until this morning. He is going to be as spoiled as Trouble (or maybe he already is). Its so easy to go overboard when they arent well ...
Hi, just want ant to get some thoughts/opinions on these names??? yes, no, maybe... :) Girl: Indi / Indy (I really like but lots of people say no!) - page 2
1-Benzyl 2-methyl piperazine-1,2-dicarboxylate 126937-43-7 safety info, 1-Benzyl 2-methyl piperazine-1,2-dicarboxylate chemical safety search, Chemical 1-Benzyl 2-methyl piperazine-1,2-dicarboxylate safety technical specifications ect.
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V. We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
The theory that trade-offs exist between longevity and performance is a pervasive paradigm in analyses of life-history evolution. However, in the case of the naturally occurring indy mutant Drosophila, lifespan has been doubled without decreases in fitness; these flies are both healthy and fertile during their entire lives. The name indy is short for mutations in a gene named Im not dead yet, which encodes a protein that transports Krebs cycle intermediates needed for intermediary metabolism. The performance trade-offs in long-lived indy flies will only be present in the flies when food is scarce, as a reduction of INDY protein expression levels reduces the efficiency by which the insect utilises calories from food.. Marden and co-authors hypothesized that performance trade-offs in indy flies may be conditional and may depend on levels of environmental stress, including the quality and quantity of food available. To test this hypothesis, the authors measured mortality rates, metabolic rates, ...
Kraemer, J.; Fischer, J. D.; Zientz, E.; Vijayan, V.; Griesinger, C.; Lupas, A.; Unden, G.: Citrate sensing by the C4-dicarboxylate/citrate sensor kinase DcuS of Escherichia coli: Binding site and conversion of DcuS to a C4-dicarboxylate- or citrate-specific sensor. Journal of Bacteriology 189 (11), S. 4290 - 4298 (2007 ...
Bromination and Subsequent Ozonisation of Ethyl 2,6-Dimethylbenzo[1.2-b, 4.5-b] difuran-3,7-dicarboxylate.. Bernatek, Erling; Ledaal, Tore; Steinsvik, Sigurd ...
Participating items for the Mega Sale, including coupons available to use and save more. Mix and Match participating items, just make sure to buy in increments of Six to get the $3 instant savings at Checkout. ...
Looking for another Goodwill location outside of Central Indiana? Visit Goodwill to find other locations.. 1.) By Phone: 1-855-GWRewards (1-855-497-3927). 2.) By Email: [email protected] 3.) Visit your local Goodwill store ...
PASC 20: Platform for Advanced Scientific Computing ConferenceProceedings of the Platform for Advanced Scientific Computing Conference ...
Ashley Sutton set an absolutely scintillating pace to top the times in second Renault UK Clio Cup testing around Brands Hatchs Indy circuit this afternoon.
Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate 843-59-4 route of synthesis, Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate chemical synthesis methods, Diethyl 2,5-dioxobicyclo[2.2.2]octane-1,4-dicarboxylate synthetic routes ect.
Eur J Hum Genet 23 (6):753-60.. 34. Schlessinger A, Sun NN, Colas C, Pajor AM (2014) Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter, NaDC3. J Biol Chem 289 (24):16998-17008.. 33. Yachdav G, Kloppmann E, Kajan L, Hecht M, Goldberg T, Hamp T, Schafferhans A, Roos M, Bernhofer M, Richter L, Ashkenazy H, Punta M, Schlessinger A, Bromberg Y, Schneider R, Vriend G, Sander C, Ben-Tal N, Rost B (2014) PredictProtein - open online prediction of protein structure and function. Nucleic Acids Res 42 (Web Server issue):W337-43.. 32. Feiglin A, Ashkenazi S, Schlessinger A, Rost B, Ofran Y (2014) Co-expression and co-localization of hub proteins and their partners are encoded in protein sequence. Mol Biosyst 210 (4):787-94.. 31. Schlessinger A. (2014) Characterizing the structure, function, and evolution of human Solute Carrier (SLC) transporters using computational approaches. In: Membrane Transport Mechanism: 3D Structure and Beyond (Springer Series in ...
This study investigated whether D,L-cis-2,3-Pyrrolidine dicarboxylate (D,L-cis-2,3-PDC), a new glutamate analogue, alters glutamate binding to cerebral plasma membranes and whether N-methyl-D-aspartate (NMDA) receptors are involved in the convulsant effect of this compound. D,L-cis-2,3-PDC reduced sodium-independent [3H]-L-glutamate binding to lysed membrane preparations from adult rat cortex and had no effect on sodium-dependent glutamate binding. Intracerebroventricular administration of D,L-cis-2,3-PDC (7.5-25 nmol/5 microl) induced generalized tonic-clonic convulsions in mice in a dose-dependent manner. The coadministration of MK-801 (7 nmol/2.5 microl), with D,L-cis-2,3-PDC (16.5 nmol/2.5 microl), fully protected the animals against D,L-cis-2,3-PDC-induced convulsions, while the coadministration of DNQX (10 nmol/2.5 microl) increased the latency to convulsions but did not alter the percentage of animals that had convulsions. These results suggest that D,L-cis-2,3-PDC-induced effects are mediated
Learn more about Dimethyl-cis-4-cyclohexene-1,2-dicarboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
diethyl 6-(trichloromethyl)-1,3,5-triazine-2,4-dicarboxylate | C10H10Cl3N3O4 | CID 35555 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
octyl N-(4-piperidin-1-ylsulfonylphenyl)carbamate,octyl N-[4-(cyclohexylsulfamoyl)phenyl]carbamate,octyl N-[4-(dimethylsulfamoyl)phenyl]carbamate,octyl N-[4-(dipropylsulfamoyl)phenyl]carbamate,O-ethyl 2-ethylpentylsulfanylmethanethioate,O-ethyl 4-methylhexylsulfanylmethanethioate,O3-tert-butyl O1-methyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-naphthalene-1,3-dicarboxylate,O-ethyl 2-ethoxycarbothioylsulfanylethylsulfanylmethanethioate,O3-methyl O1-phenyl 1,2,2-trimethylcyclopentane-1,3-dicarboxylate,O-ethyl (7-nitro-9-oxidanylidene-fluoren-4-yl)sulfanylmethanethioate,O1-ethyl O4-methyl 3-(methoxymethyl)-2-propanoyl-butanedioate,O3-ethyl O1-methyl 4-oxidanylidenequinolizine-1,3-dicarboxylate,oxolan-2-yl(diphenyl)methanol,O4-methyl O1-(4-nitrophenyl) 2-(phenylmethoxycarbonylamino)butanedioate,O4-methyl O1-(4-nitrophenyl) 2-[2-(phenylmethoxycarbonylamino)ethanoylamino]butanedioate,O4-methyl O1-(4-nitrophenyl) 2-[[3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]butanedioate,O3-ethyl O1-methyl 4,6
The 2016 schedule was released on October 27, 2015.[20] Phoenix and Road America returned to the calendar. Long Beach was removed from the schedule, and with the IndyCar Series not returning to the Milwaukee Mile, Indy Lights will not return either. The Grand Prix of Boston was announced in late May 2015. The race was scheduled to be run on Labor Day Weekend on September 4, 2016. The proposed street circuit was based in the Boston Seaport District. On April 29, 2016, Boston newspapers reported that the race weekend, which was to include an Indy Lights support race, had been canceled.[21] The race was replaced by a race at Watkins Glen International, on the same weekend.[22] The season will expand to 18 races, two more than the previous season. All races on road courses and street circuits will be double headers with the exception of Watkins Glen, which, like the oval tracks, will have only one race. All races will be run in support of IndyCar races except the final weekend at Mazda Raceway ...
Now, the annoying stuff: The huge waiting room was empty when I arrived today, so I brought Indy inside and went over to the far corner and sat down -- he was on the bench with his head in my lap and I was sitting between him and the rest of the room. Everything was fine for about 10 minutes, until a lady with an old dog walked in. She walked her dog (on a flexi of course!) DIRECTLY towards me and Indy. When she got within 15 feet and I realized she wasnt going to stop, I said to her Im sorry, but Indy doesnt play well with others. She took another couple of steps and Indy lit up at her and the dog. The woman got pissed and pulled her dog back, giving me major attitude. I got Indy under control -- he never left the bench and never got by me at all. I made him sit right back where he was originally and I sat next to him. All this took about 30 seconds before he was calm and back by my side and pretty much ignoring her dog ...
Race Face Sulphur Indy Short Sleeved MTB Jersey, available now at Americas leading action sports store, FreestyleXtreme | United States
Fans heading to the Indy 500 to see Foreigner play Carb Day will be fine in shorts, but race fans may want to pack a poncho for Sunday.