... , Yuji Asai, Hiroyuki Morimoto, Yoshio Mabuchi1, Eisuke Sakuma, Nobuyuki Sh
Uncoupling Endothelial Nitric Oxide Synthase Is Ameliorated by Green Tea in Experimental Diabetes Mellitus by Re-Establishing Tetrahydrobiopterin ...
This study is an attempt to elucidate of agmatine effects upon leukocyte apoptosis in experimental diabetes mellitus (EDM). We demonstrated the increase in numbers of the leukocytes with both early and late signs of apoptosis at diabetes. Further changes in the morphofunctional state of the leukocyt …
In the present study, we found that tramadol has the ability to lower the plasma glucose levels of STZ-induced diabetic rats. This is consistent with our previous report that activation of opioid μ-receptors could decrease the plasma glucose concentration in STZ-induced diabetic rats (7).. Naloxone has been used in studying the relation between β-endorphin and glucose homeostasis (21). Pharmacologically, naloxone is a nonselective antagonist of opioid receptors (21), and naloxonazine is a selective antagonist of opioid μ-receptors (22). We found that naloxone and naloxonazine, at doses sufficient to block opioid μ-receptors, inhibited the plasma glucose-lowering action of tramadol in STZ-induced diabetic rats. It can thus be considered that opioid μ-receptor activation is involved in the plasma glucose-lowering action of tramadol in STZ-induced diabetic rats. Actually, either naloxone or naloxonazine given alone was ineffective in altering plasma glucose, indicating that opioid receptors ...
TY - JOUR. T1 - Proteome analysis of altered proteins in streptozotocin-induced diabetic rat kidney using the fluorogenic derivatization-liquid chromatography-tandem mass spectrometry method. AU - Tsai, Pei Yun. AU - Chen, Shih Ming. AU - Chen, Hsiang Yin. AU - Li, Yi Chieh. AU - Imai, Kazuhiro. AU - Hsu, Kuang Yang. AU - Lee, Jen Ai. PY - 2013/3. Y1 - 2013/3. N2 - To find new molecular markers for early diagnosis of diabetic nephropathy, we applied fluorogenic derivatization-liquid chromatography-tandem mass spectrometry to identify the differentially expressed proteins in the kidney of control and streptozotocin-induced diabetic rats. The Sprague-Dawley rats were injected with the sodium citrate buffer or streptozotocin and then killed after 1, 4, 12 and 24 weeks. The results showed that seven proteins were significantly changed after 1 week of injection. Only one protein had significantly changed after 4 weeks of injection. However, after 12 weeks of injection, the number of altered proteins ...
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Abstract: Participation of renal prostanoids in development of diabetes-induced nephropathy was studied in rats with streptozotocin diabetes. Development of diabetic nephropathy occurred with simultaneous decreases in production of intrarenal natriuretic, depressor prostaglandin and prostacyclin as well as with increases in content of antinatriuretic, pressor, prothrombogenic TxA2. The imbalance observed in the production of renal prostanoids contributed slightly to impairments of hemodynamics, osmo- and ion regulating functions of kidney, i.e. to formation of diabetic nephropathy in the experimental ...
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A large number of studies have documented the evidence that progression of diabetes leads to various secondary diabetic complications among which nephropathy is a serious complication with an increasing prevalence worldwide [22]. The nephropathy disease is characterized by morphological and ultra structural changes in the kidney including expansion of the molecular matrix. Even though, the pathogenesis of diabetic nephropathy is complex and still not fully elucidated, few biochemical changes such as increase in polyol pathway flux, increased AGEs formation, have been actively studied for their role in the development of diabetic nephropathy. Increased matrix proteins leading to decreased GFR is considered as a marker for the progression of the Diabetic nephropathy disease. Elevation of serum creatinine levels and BUN in diabetic rats is used as an index of altered GFR in diabetic nephropathy [23].. Results of the present study have corroborated with the previous reports in which administration ...
The profile of hepatic microsomal cytochrome P450 expressed in the male and female rat was dramatically altered by streptozotocin-induced diabetes. In the diabetic male, P450 forms IIC11, IIC13, IIA2, and IIIA2 were suppressed and forms IIA1 and IIC12 were induced to the levels observed in the immature male rat. A 6- to 8-fold induction of P450 IIE1 was detected in both male and female diabetic rats. A member of the P450 IIIA family was also induced in the diabetic female rat. Accompanying the change in P450 profile in the diabetic male rat was reduction in circulating testosterone and tetraiodothyronine concentrations and a sharp diminution of the normally pulsatile pattern of growth hormone secretion. In contrast to the male rat, the growth hormone secretion pattern in the diabetic female rat was unchanged from control. The hormone and P450 profiles detected in the diabetic male rat suggest a reversion to an immature physiological state. Testosterone replacement treatments carried out for 2 ...
OBJECTIVE To investigate whether ageing and diabetes alter the expression of the gap junction protein connexin43 (Cx43) and of particular purinoceptor (P2R) subtypes in the corpus cavernosum and urinary bladder, and determine whether changes in expression of these proteins correlate with development of erectile and bladder dysfunction in diabetic and ageing rats. MATERIALS AND METHODS Erectile and bladder function of streptozotocin (STZ)-induced diabetic, insulin-treated and age-matched control Fischer-344 rats were evaluated 2, 4 and 8 months after diabetes induction by in vivo cystometry and cavernosometry. Corporal and bladder tissue were then isolated at each of these sample times and protein expression levels of Cx43 and of various P2R subtypes were determined by Western blotting. RESULTS In the corpora of control rats ageing was accompanied by a significant decrease in Cx43 and P2X(1)R, and increase in P2X(7)R expression. There was decreased Cx43 and increased P2Y(4)R expression in the ageing
Title:Goto-kakizaki Rats: Its Suitability as Non-obese Diabetic Animal Model for Spontaneous Type 2 Diabetes Mellitus. VOLUME: 9 ISSUE: 5. Author(s):Muhammad Sajid Hamid Akash, Kanwal Rehman and Shuqing Chen. Affiliation:Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University Hangzhou, China.. Keywords:None Obese Animal Model, GK Rats, Islet Inflammation, Insulin Resistance, Hyperglycemia, Diabetic Nephropathy, Diabetes Mellitus, Glucose Tolerance.. Abstract:β-cell dysfunction and apoptosis are recognized as a major cause of insufficient insulin secretion in response to high blood glucose and metabolic demand. As a consequence, type 2 diabetes mellitus (T2DM) is known to occur. Taking into account the etiology of T2DM, to conduct investigational studies directly on human diabetic patients seems to be unsuitable; thereby, various animal models have been established to investigate the pathogenesis of T2DM. Among these models, ...
BioAssay record AID 185258 submitted by ChEMBL: Percent inhibition of sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)- induced diabetic rats at peroral dose of 30 mg/kg (preventive effect).
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The aim of the present study was to investigate the relationship between speed during maximum exercise test (ET) and oxygen consumption (VO2) in control and STZ-diabetic rats, in order to provide a useful method to determine exercise capacity and prescription in researches involving STZ-diabetic rats. Male Wistar rats were divided into two groups: control (CG, n = 10) and diabetic (DG, n = 8). The animals were submitted to ET on treadmill with simultaneous gas analysis through open respirometry system. ET and VO2 were assessed 60 days after diabetes induction (STZ, 50 mg/Kg). VO2 maximum was reduced in STZ-diabetic rats (72.5 ± 1 mL/Kg/min-1) compared to CG rats (81.1 ± 1 mL/Kg/min-1). There were positive correlations between ET speed and VO2 (r = 0.87 for CG and r = 0.8 for DG), as well as between ET speed and VO2 reserve (r = 0.77 for CG and r = 0.7 for DG). Positive correlations were also obtained between measured VO2 and VO2 predicted values (r = 0.81 for CG and r = 0.75 for DG) by linear
TY - JOUR. T1 - Proteomics analysis identifies molecular targets related to diabetes mellitus-associated bladder dysfunction. AU - Yohannes, Elizabeth. AU - Chang, Jinsook. AU - Christ, George J.. AU - Davies, Kevin P.. AU - Chance, Mark R.. PY - 2008/7. Y1 - 2008/7. N2 - Protein expression profiles in rat bladder smooth muscle were compared between animal models of streptozotocin-induced diabetes mellitus (STZ-DM) and age-matched controls at 1 week and 2 months after induction of hyper-glycemia with STZ treatment. At each time point, protein samples from four STZ-DM and four age-matched control rat bladder tissues were prepared independently and analyzed together across multiple DIGE gels using a pooled internal standard sample to quantify expression changes with statistical confidence. A total of 100 spots were determined to be significantly changing among the four experimental groups. A subsequent mass spectrometry analysis of the 100 spots identified a total of 56 unique proteins. Of the ...
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
Diabetes mellitus (DM) is metabolic diseases characterized by chronic hyperglycemia due to reducing in insulin secretion, insulin function, or both. Ezetimibe is a drug that lowers plasma cholesterol levels. A total of 18 male adult albino rats were used in this study. The animals randomized into 3 groups (of 6 rats each). Rats in first group were injected with citrate buffer only and used as healthy control group. While the rats in other two groups were injected with streptozotocin (STZ) at a dose of 60 mg/kg I.P. and treated as following (for 12 weeks), diabetic control group rats received no treatment. Ezetimibe treated group rats received Ezetimibe 6 mg/kg orally once daily. Every 2 weeks, blood glucose level is measured. At the end of 12th weeks, blood samples were collected to measure the blood glucose level and superoxide dismutase activity, and then the animals were sacrificed. The pancreas was removed for histopathology assessment for the degree of islets damage. In result, Ezetimibe was
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
A balanced meal according to the Atkins Diet. How Diabetes Affects Your Diet Quotes Being hIGHLIGHTS OF PRESCRIBING INFORMATION disposable prelled pen (3) before stopping IV insulin. A meta-analysis of rectal NSAIDs in the prevention of post-ERCP pancreatitis. Tags: Diseases & Conditions Diabetes Healthy food Type 2 diabetes Curd Yoghurt. In Type 1 diabetes the disease is caused by the destruction of beta cells in the pancreas. Guidelines developed by the American Geriatrics Association reflect some of the unique diabetes care needs of older adults. a flexible meal plan has been proposed in adolescents with type 1 diabetes where insulin.. We also offer a large selection of accessories for your special day. Optimum HealthCare Inc. Stress is a potential contributor to chronic hyperglycemia in diabetes.. My husband loves this casserole but it Diabetic Exchanges: 3 lean Originally published as Enchilada Casser-Ole! in Healthy Cooking Feuary/March atherosclerosis in mice with liver-specific ablation ...
In this study, the diabetic model was generated by a single large-dose injection of STZ. Under such conditions, STZ destroys β-cells via DNA alkylation (Lenzen, 2008). The model differs from the autoimmune diabetic model of non-obese diabetes (NOD) or multiple low-dose STZ-induced diabetes, where islet inflammation is the salient pathological feature (Bassi et al., 2012; Ezquer et al., 2012; George et al., 2002; Leiter, 1982; Paik et al., 1980). The non-inflammatory diabetic model used here, which was confirmed by the lack of inflammatory cell infiltrates in the islet of untransplanted but STZ-treated rats (Fig. 2B), allows us to better examine the direct trophic effect of uMSCs on β-cell survival with fewer complications from their immunomodulatory activities. In this study, uSMC transplantation retarded the hyperglycemic progression 6 days after the treatment, yet the treatment only modestly reversed hyperglycemia despite the extended 42-day treatment. Multiple factors might influence the ...
by David M. Reutter. A $1 million settlement was reached in May 2019 in a lawsuit alleging the Atlanta City Detention Center (ACDC) left a pretrial detainee in an unlit confinement cell to die from untreated diabetes.. When Wickie Yvonne Bryant, 55, was booked into ACDC on September 14, 2015, it was noted that she suffered from schizophrenia, bipolar disorder, diabetes, and hypertension. She said that she was taking medication for all three diagnoses. An intake test revealed an "extremely elevated blood-glucose level" of 353 mg/dl, but she refused to take insulin, saying it made her sick.. She was subsequently prescribed Metformin, an oral diabetic medication. Yet, from her intake until October 5, 2015, Bryant refused her "diabetic treatment," which meant blood testing and medication. She submitted a request on September 20 advising officials about her medical and mental health treatment at several medical facilities.. Despite laying out her history of care regimen, ADCDs medical staff never ...
What percent of patients with type 2 diabetes have already developed one or more microvascular complications by the time of their diabetes diagnosis, according to the American Diabetes Association (ADA)? ...
The present study is aimed to evaluate the hypoglycaemic effect of glibenclamide monotherapy on streptozotocin-induced diabetic rats and therapeutic i..
Learn how Diabetes leads to Anemia and what Anemia is, learn about the connection between the damage of your Kidneys and Diabetes.
Axonal swellings in neurons from STZ-diabetic rats exposed to high glucose represent accumulations of mitochondria and phosphorylated NFH, which are eliminated
The present study is aimed to evaluate the hypoglycaemic effect of glibenclamide monotherapy on streptozotocin-induced diabetic rats and therapeutic impact of this agent on various..
Diabetic nephropathy (DN) is a major complication of diabetes and is caused by an imbalance in the expression of certain genes that activate or inhibit vital cellular functions of kidney. Despite several recent advances, the pathogenesis of DN remains far from clear, suggesting the need to carry out studies identifying molecular aspects, such as gene expression, that could play a key role in the development of DN. There are several techniques to analyze transcriptome in living organisms. In this study, the suppression subtractive hybridization (SSH) method was used to generate up- and down-regulated subtracted cDNA libraries in the kidney of streptozotocin (STZ)-induced diabetic rats. Northern-blot analysis was used to confirm differential expression ratios from the obtained SSH clones to identify genes related to DN. 400 unique SSH clones were randomly chosen from the two subtraction libraries (200 of each) and verified as differentially expressed. According to blast screening and functional annotation
Objective: It is increasingly recognized that vascular cognitive impairment may be a new complication of the disease in both type 1 and type 2 diabetes. We have shown that diabetic Goto-Kakizaki rats present with cognitive deficits and vascular dysfunction, especially impaired relaxation that can be ameliorated by Toll-like receptor-2 (TLR2) inhibition. Since brain function heavily depends on constant perfusion, and decreased cerebral blood flow (CBF) precedes development of inflammation and cognitive deficits, we hypothesized that TLR2 knockout would confer a protection from diabetes mediated cognitive decline.. Methods and Results: Wild-type (WT) and TLR2 knockout (KO) control and diabetic mice were used. Diabetes was induced by streptozotocin (STZ) injection. 14 weeks after, cerebral perfusion was measured by MRI and cognitive function was assessed by a battery of tests including Y-maze and fear conditioning. There was no difference in cerebral perfusion in WT and TLR2 KO mice (CBF ...
How Diabetes affects your Feet: pain, pain relief, tingling, pins and needles sensations, complications, symptoms of complications, how to prevent complications
We previously prepared ophthalmic formulations containing cilostazol (CLZ) nanoparticles by bead mill methods (CLZnano), and found that instillation of CLZnano into rat eyes supplies CLZ into the retina. In this study, we investigated changes in the electroretinograms (ERG) of streptozotocin-induced diabetic rats (STZ rats), a model of diabetes mellitus. In addition, we demonstrated that dispersions containing CLZ nanoparticles attenuate changes in the ERG of STZ rats. The instillation of CLZnano had no effect on body weight or plasma glucose and insulin levels. Furthermore, no corneal toxicity was observed in the in vivo study using STZ rats. The a-wave and b-wave levels in addition to oscillatory potentials (OP) amplitude decreased in STZ rats two weeks after the injection of streptozotocin, with the instillation of CLZnano attenuating these decreases. In addition, the level of vascular endothelial growth factor (VEGF) in the retinas of STZ rats was 9.26-fold higher than in in normal rats, with this
Diabetes-induced visual dysfunction is associated with significant neuroretinal cell death. The current study was designed to investigate the role of the Protein Regulated in Development and DNA Damage Response 1 (REDD1) in diabetes-induced retinal cell death and visual dysfunction. We recently demonstrated that REDD1 protein expression was elevated in response to hyperglycemia in the retina of diabetic rodents. REDD1 is an important regulator of Akt and mammalian target of rapamycin and as such plays a key role in neuronal function and survival. In R28 retinal cells in culture, hyperglycemic conditions enhanced REDD1 protein expression concomitant with caspase activation and cell death. By contrast, in REDD1-deficient R28 cells, neither hyperglycemic conditions nor the absence of insulin in culture medium were sufficient to promote cell death. In the retinas of streptozotocin-induced diabetic mice, retinal apoptosis was dramatically elevated compared with nondiabetic controls, whereas no ...
Treatment of male Sprague-Dawley rats with streptozotocin resulted in a blood glucose level of over 400 mg/dL within one week (| 350 is considered diabetic). Subsequent treatment with the insulin-mimetic agents vanadate and selenate affected how much food the rats consumed as well as their growth rate when compared to controls. Diabetic controls consumed more food and gained weight more quickly than their treated counterparts. Non-diabetic controls (which were not injected with streptozotocin) consumed less food than the diabetic animals but gained more weight. Regulation of G6PDH and FAS at the level of gene expression is well documented, and preliminary studies show that diabetic rats treated with vanadate or selenate exhibit a stimulation in the enzyme activities of (G6PDH) and (FAS) above diabetic control levels. Thus, it seems that both vanadate and selenium have some regulatory influence that is similar to insulin over the enzyme activities of G6PDH and FAS.
Results-After stroke, mice with diabetes mellitus exhibited significantly increased lesion volume and brain hemorrhagic and neurological deficits compared to mice without diabetes mellitus. Bielshowsky silver, luxol fast blue, amyloid precursor protein, and NG2 expression were significantly decreased, indicating WM damage, and matrix metalloproteinase (MMP)-9 activity was significantly increased in the ischemic brain of mice with diabetes mellitus. Subanalysis of similar lesions in mice with and without diabetes mellitus demonstrated mice with diabetes mellitus had significantly increased WM damage than in mice without diabetes mellitus (P,0.05). To investigate the mechanism underlying diabetes mellitus-induced WM damage, oxygen-glucose deprivation-stressed premature oligodendrocyte and primary cortical neuron cultures were used. High glucose increased MMP-2, MMP-9, cleaved caspase-3 levels, and apoptosis, as well as decreased cell survival and dendrite outgrowth in cultured primary cortical ...
DESCRIPTION (provided by applicant): Acute stroke is one of the most under-treated serious diseases in the United States. A major challenge in the study of stroke is that most treatments effective in experimental animals have failed in humans. One possible explanation is that targets for protection have been identified in otherwise healthy animals upon which focal cerebral ischemia has been imposed. Type 2 diabetes that is often accompanied by hypertension is the most rapidly increasing risk factor for stroke and also increases the risk of hemorrhage and poor outcome of stroke. While it is known that the integrity of cerebral blood vessels is critical in the pathophysiology of stroke, targets to protect the vasculature from ischemic injury in the presence of preexisting vascular disease are yet to be identified. The objective of this application is to conduct feasibility studies to test our global hypothesis that diabetes-induced changes in the cerebral microvessel wall increase the risk of ...
I guess it just feels like the low after a week of highs, but I feel so sad and lonely today, and only yesterday I met my first goal. Married to the same guy...
INTRODUCTION It has been shown that diabetes predisposes the patient for neuropsychiatric deficits as stroke, cerebrovascular diseases, diabetic encephalopathy, depression and anxiety (Kuhad & Chopra, 2007). Diabetic encephalopathy, characterized by impaired cognitive functions and neurochemical and structural abnormalities, involves direct neuronal damage caused by intracellular glucose (Kuhad & Chopra). Primary diabetic encephalopathy may cause by hyperglycemia and impaired insulin action diabetes. In contrast, secondary diabetic encephalopathy appears to arise from hypoxic-ischemic insults due to underlying microvascular disease or as a consequence of hypoglycemia (Sima et al., 2004). The hippocampal formation plays an important role in spatial navigation and the formation of certain types of memories (Sneider et al., 2006). Subregional models of hippocampal function suggest that CA1 function is critical in correctly identifying novel relationships among objects within a particular spatial ...
مجله علمی دانشگاه علوم پزشکی و خدمات درمانی بیرجند . داراي رتبه علمي- پژوهشي از كميسيون نشريات علوم پزشكي كشور Journal of Birjand University of Medical Sciencesfrom iran
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To the Editor:. We read with great interest the article by Hsueh et al in a recent edition of Circulation Research.1 We concur with the efforts of the Animal Models of Diabetic Complications Consortium (AMDCC) to attempt to create clinically relevant models of diabetes induced cardiovascular disease. Like the AMDCC, our own group has studied extensively diabetic complications in the retina,2 kidney,3 and heart in the diabetic Ren-2 rat, a model of enhanced tissue based renin-angiotensin system. After induction of diabetes with streptozotocin, the diabetic Ren-2 rat develops many of the criteria suggested by Hsueh et al for the validation of diabetic cardiomyopathy, such as invasive evidence of systolic and diastolic dysfunction, altered gene expression, and evidence of oxidative stress, activation of profibrotic signaling pathways, and changes in myocardial calcium handling.4 Furthermore, the clinical relevance of any rodent model must be based on the predictive power for both negative and ...
In the study of "Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway" by Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P., posted in US National Library of Medicine National Institutes of Health, researcher concluded that BFT (benfotiamine) protects from diabetes mellitus-induced cardiac dysfunction through pleiotropic mechanisms, culminating in the activation of prosurvival signaling pathway. Thus, BFT merits attention for application in clinical practice ...
This study determined if muscarinic receptors could mediate the cold stress-induced detrusor overactivity induced in type 2 diabetes mellitus rats. Ten-week-old female Goto-Kakizaki diabetic rats (n = 12) and Wister Kyoto non-diabetic rats (n = 12) were maintained on a high-fat diet for 4 weeks. Cystometric investigations of the unanesthetized rats were carried out at room ...
The purpose of this study was to assess the in vivo ability of glucosaminic acid-cobalt (II) chelate to reduce glycemia. Different concentrations of chelate solution were administrated to mice with diabetes induced by streptozotocin. Dail
Diabetes can reduce the production of cholesterol in the brain, which is vital to communication between cells involved in memory, pain and motor control
Latinos are more likely to get diabetes than people in other ethnic groups, and one in four Latinas has diabetes. Find out whether youre at risk, and how to...
Diabetes: Treating even mild diabetes that develops during pregnancy helps keep moms and babies from gaining too much weight and makes for easier deliveries, research shows.
Patient: It was one week ago when my grandfather was admitted in the hospital because he was gasping for air. He has ulcer and diabetes (he has only a small thumb-size wound at his feet) but hes still strong. That night in the hospital ward, he was injected and was given a medicine to monitor his bp, sugar, and etc. At the second night, he was almost ready to go home and he still has his own presence of mind. After some time, he starts hallucinating, and uttering words we can no longer understand. He suddenly fell then goes in convulsion and sweats too much thats why he was brought to the ICU and was put into cardiac arrest. After some hours (morning, 3rd day), his eyes dilated, can no longer speak, gasps for air so the doctor decided to use a ventilator and there were some tube inserted in his mouth. He still can hear us but the machine now was his only life. The doctor cant diagnosed easily what was going on. They gave him many medicines and found out that he has many implications (sepsis, ...
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Diabetes Mellitus is a metabolic disease characterized by increase levels of glucose in the blood, termed as (hyperglycemia) which means "hyper" (elevated) "glyco" or "glucose" (sugar) and "emia" (blood) elevated sugar in the blood. It results from defects in insulin secretion, insulin action or both. Normally a certain amount of sugar circulates in the blood, around 70-120 mg/dl. The major sources of this glucose are absorption of ingested food in the gastrointestinal tract and formation glucose by the liver from the food substances termed as (gluconeogenesis) "gluco" (sugar) "neo" (new) and "genesis" (formation ...