Product Name: Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops. Common Name: antibacterial prepration for eye and ear. Strength: 0.3% Ofloxacin + 0.1% Dexamethasone Sodium Phosphate. Description: Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.. Dexamethasone Sodium Phosphate, a synthetic adrenocortical steroid, is a white or slightly yellow crystalline powder. It is freely soluble in water and is exceedingly hygroscopic.. Indications and Usage:. Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops is used to treat certain eye conditions due to inflammation or injury. Dexamethasone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.. This medication may also be used to treat swelling, redness, and itching of the outer ear due to inflammatory conditions.. Pack Size: Ofloxacin and Dexamethasone Sodium Phosphate Eye and Ear Drops ...
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Dexamethasone Sodium Phosphate Inj: Dexamethasone belongs to the group of medications known as corticosteroids. It may be used to treat a wide variety of conditions.
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Trade Name: Decadron, Dexasone, Diodex, Hexadrol, Maxidex. For which conditions is this drug approved? Dexamethasone is used in combination with other agents for the treatment of myeloma and lymphomas. Dexamethasone may also be used to help prevent or reduce nausea and vomiting, to reduce swelling and related pressure, or as an anti-inflammatory agent. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Dexamethasone is referred to as a glucocorticoid or corticosteroid. Dexamethasone may produce anti-cancer effects through several speculated mechanisms. One such mechanism may be the inhibition of inflammatory agents in the body, which have been implicated in the development or growth ...
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The objective of this study is to assess the safety and efficacy of Ocular Iontophoresis with Dexamethasone Phosphate 40 mg/mL 7.5 mA-min at 2.5 mA and Ocular Iontophoresis with Dexamethasone Phosphate 40 mg/mL 10.5 mA-min at 3.5 mA compared to placebo for the treatment of the signs and symptoms of dry eye ...
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Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF. ...
Dexamethasone Sodium Phosphate is indicated as a rapid adrenal glucocorticoid and/or anti-inflammatory agent. Each ml contains 4 mg dexamethasone sodium phosphate, equivalent to 3 mg dexamethasone. Dexamethasone is a synthetic corticosteroid and possesses
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This study was planned to determine whether a short period dexamethasone treatment induce alveolar bone loss or not, therefore, twenty six male albino rabbits were divided into three groups as follow: Test groups I (10 rabbits) received 1.56 mg/kg dexamethasone intraperitoneal injection daily for two weeks, test group II (10 rabbits) received 3.12 mg/kg dexamethasone intraperitoneal injection daily, and the control group (6 rabbits) received saline solution for same period. The animals were sacrificed and histological sections were prepared from the alveolar bone of molar areas of mandible, as well as morphometric analysis of osteoclasts number was performed. The results showed a significant increase in the number of osteoclasts, which indicates that bone loss, is quite inevitable secondary to dexamethasone treatment even in a short period of treatment for two weeks.
Acute and sub chronic effects of oral dexamethasone on anxiety and memory in mice were evaluated using the elevated plus maze, Y maze and radial arm maze. Adult male Swiss albino mice assigned to five groups were given vehicle (normal saline), a standard drug (Diazepam or Scopolamine) or one of three selected doses of dexamethasone (0.5, 1.0 and 1.5 mg/kg) daily for a period of 14 days. Behavioral tests were carried out on days 1 and 14 after administration. Results were analysed using a one-way ANOVA followed by a posthoc test (Student-Newman-Keul) and expressed as mean ± S.E.M. Elevated plus maze test showed a significant reduction in the time spent in the open arm and in the number of open arm entries compared to control. Results of radial arm and Y maze tasks showed an improvement in spatial memory following dexamethasone administration. Y maze locomotor activity was significantly increased, although radial arm maze exploration did not increase significantly. The study concluded that oral
CAH is a genetic steroidogenesis disorder. The most common form, 21OHD, leads to cortisol deficiency and, in turn, an excess of androgen, a hormone that promotes the development and maintenance of male sex characteristics. As a result of this androgen excess, prepubescent males and newborn, prepubescent, and grown females exhibit mature masculine characteristics. Prenatal treatment with dexamethasone, a corticosteroid that decreases androgen levels, has been shown to prevent the development of abnormal genitalia in female infants. The long-term effects of this treatment, however, have not been evaluated. This study will determine whether prenatal dexamethasone treatment causes any long-term side effects by examining children and young adults who received dexamethasone as fetuses and their mothers, who were exposed to dexamethasone while pregnant.. This study has three parts. In Part 1 of the study, participants will provide written consent for release of their medical records from their ...
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Peter Horby, Professor of Emerging Infectious Diseases in the Nuffield Department of Medicine, University of Oxford, and one of the Chief Investigators for the trial, said, "Dexamethasone is the first drug to be shown to improve survival in COVID-19".. For patients on ventilators, the risk of death dropped from 40% to 28%, and for those on oxygen it dropped from 25% to 20%.. No treatment for COVID-19 - the disease caused by the new coronavirus and which has killed more than 431,000 people globally - has been shown to reduce the mortality of the disease, although Gilead Sciences Incs remdesivir shortened the recovery time for hospital patients.. For patients on oxygen, it cuts the chances of death from coronavirus by a fifth.. Its understandable that these researchers would want to get the news out as soon as possible, given the possibility that dexamethasone could, based on the results, save lives immediately.. Britain will immediately start giving dexamethasone to coronavirus patients, after ...
Few trials compare oral dexamethasone head-to-head with oral prednisone. In 2001, Qureshi et al14 compared 2 days of dexamethasone (0.6 mg/kg daily; maximum 16 mg/d) to 5 days of prednisone (1 mg/kg daily; maximum 60 mg/d). Dexamethasone had a similar efficacy as measured by relapse rates (7.4% vs 6.9%, P = .84), hospitalization rates (11% vs 12%), and the persistence of symptoms at 10 days (22% vs 21%). The patients treated with dexamethasone had increased compliance (99.6% vs 96%, P = .004) and fewer side effects, such as vomiting (0.3% vs 3%, P = .008). Part of the increased compliance in the dexamethasone group was believed to be owing to patients being discharged from EDs with the medication, whereas prednisone required a prescription to be filled at a pharmacy. Although dispensing medication is feasible in some EDs, it is often not an option in the ambulatory practice setting. Furthermore, dexamethasone is given at a smaller volume and can be mixed with better-tasting syrups to allow for ...
Outcomes at School Age after Postnatal Dexamethasone Therapy for Lung Disease of Prematurity. Yeh, Tsu F.; Lin, Yuh J.; Lin, Hung C.; Huang, Chao C.; Hsieh, Wu S.; Lin, Chyi H.; Tsai, Cheng H. // New England Journal of Medicine;3/25/2004, Vol. 350 Issue 13, p1304 Background: We studied the outcomes at school age in children who had participated in a double-blind, placebo-controlled trial of early postnatal dexamethasone therapy (initiated within 12 hours after birth) for the prevention of chronic lung disease of prematurity. Methods: Of the 262 children... ...
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This medication is used to treat various conditions such as severe allergic reactions, arthritis, blood diseases, breathing problems, certain cancers,...
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Purpose : To examine the distribution of dexamethasone in ocular and plasmic samples following CCSDD of dexamethasone disodium phosphate in rabbit, and to compare that with two traditionally routes: subconjunctival injection and intravenous injection. Methods : New Zealand white rabbits (n=6/time/group) were included in the experiments. There are three groups including controllable continuous sub-tenon drug delivery system (CCSDD) group, intravenous injection (IV) group and subconjunctival injection (SC) group. Under general anesthesia, tube were implanted on the scleral surface in the CCSDD group. After implantation, trickled 0.3 ml initial doses of 5 mg/ml dexamethasone disodium phosphate, and start timing, and then constantly perfused at a rate of 0.1 ml/h for 10 hours using a pump. We administrated 1mg/Kg dexamethasone disodium phosphate intravenously in IV group and 0.3ml of 5mg/ml dexamethasone disodium phosphate into sub-conjunctive in SC group. At different time point within 24h, the ...
Pediatric Subjects Aged 4 to 11 Years: The efficacy of Ventolin HFA was evaluated in one 2-week, randomized, double-blind, placebo-controlled trial in 135 pediatric subjects aged 4 to 11 years with mild to moderate asthma. In this trial, subjects
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TY - JOUR. T1 - Lack of therapeutic improvement of liver fibrosis in rats by dexamethasone in spite of ascites amelioration. AU - Ki, Sung Hwan. AU - Choi, DalWoong. AU - Kim, Choon Won. AU - Kim, Sang Geon. PY - 2005/2/28. Y1 - 2005/2/28. N2 - Pathophysiology of liver fibrosis (LF) includes hepatic parenchymal cell destruction and connective tissue formation. Although dexamethasone has been used in the liver diseases, there is controversy over the beneficial effects of dexamethasone on LF. Previous studies showed that CCAAT/enhancer binding protein-β (C/EBPβ) activation contributes to hepatocyte regeneration and dissolution of fibrosis and that dexamethasone activates C/EBPβ whereas C/EBPβ-mediated gene induction by dexamethasone is antagonized by a corepressor. The present study investigated the possible therapeutic effect of dexamethasone for the treatment of LF in rats. We injected rats with multiple doses of dimethylnitrosamine (DMN) for 4 weeks and then used the LF rats to determine ...
Dexamethasone for Uveitis on PBS. The Royal Australian and New Zealand College of Ophthalmologists is pleased with the announced introduction of dexamethasone (Ozurdex®) as a Pharmaceutical Benefits Scheme (PBS) authority prescription for non-infectious uveitis affecting the posterior segment.. The inclusion of the medication on the PBS means that approved patients will not have to pay the full price for the medication. Before 1 April 2018, patients living with uveitis who are prescribed dexamethasone may have needed to pay over $2,700 per course for the treatment and management of the condition. From 1 April 2018, approved patients are able to purchase the medication with access to the PBS maximum patient co-payment rate of $39.50 per course of treatment, or at $6.40 concession.. RANZCO advocated for the inclusion of dexamethasone onto the PBS, in order to allow uveitis patients access to a potentially vision-saving medication. In the decision of the Pharmaceutical Benefits Advisory Committee, ...
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Chemicals and drugs were purchased from Sigma-Aldrich (St. Louis, MO) unless otherwise stated. Dexamethasone was prepared in 1% ethanol vehicle for intragastric administration. PGE2 was dissolved in 0.01 M phosphate-buffered saline for intraperitoneal injection.. Part I: Dexamethasone Treatment and Mucosal Damage. To determine the non-ulcerogenic dose of dexamethasone, rats were given dexamethasone intragastrically at the maximal dose of 0.2 mg/kg once daily for a period of 9 days. They were sacrificed on day 10 and the gastric mucosa damage was assessed by morphological observation under magnifying glass and histological examination with a microscope. The specimens with hematoxylin-eosin stain were assessed according to the criteria of Whittle et al. (1990) with modification. The microscopic scoring was defined as follows: 1) epithelial cell damage and glandular disruption; 2) hemorrhagic damage in the mucosa; and 3) deep necrosis and ulceration. For further comparisons in this part with the ...
Trade Name: Decadron, Dexasone, Diodex, Hexadrol, Maxidex. For which conditions is this drug approved? Dexamethasone is used in combination with other agents for the treatment of myeloma and lymphomas. Dexamethasone may also be used to help prevent or reduce nausea and vomiting, to reduce swelling and related pressure, or as an anti-inflammatory agent. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Dexamethasone is referred to as a glucocorticoid or corticosteroid. Dexamethasone may produce anti-cancer effects through several speculated mechanisms. One such mechanism may be the inhibition of inflammatory agents in the body, which have been implicated in the development or growth ...
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