|strong|Mouse anti Human desmoglein 2 monoclonal antibody, clone 6D8|/strong| recognizes human desmoglein 2, a single pass type 1 membrane glycoprotein with 4 extracellular |a href=https://prosite.ex…
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Risks for Pemphigus foliaceus, Pemphigus foliaceus treatments, recommended products for Pemphigus foliaceus, ways to prevent Pemphigus foliaceus, causes of Pemphigus foliaceus
TY - JOUR. T1 - Epitope analysis of antidesmoglein 1 autoantibodies from patients with pemphigus foliaceus across different activity stages. AU - Kamiya, K.. AU - Aoyama, Y.. AU - Yamasaki, O.. AU - Kamata, A.. AU - Yamagami, Jun. AU - Iwatsuki, K.. AU - Tokura, Y.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Background Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are closely related, but clinically distinct, autoimmune blistering diseases caused by autoantibodies against desmoglein (Dsg)1 and Dsg3, respectively. Using ethylenediaminetetraacetic acid (EDTA)-treated Dsg3 enzyme-linked immunosorbent assay (ELISA) we have shown that the proportion of anti-Dsg3 antibodies against calcium-dependent epitopes decreased upon shifting to the inactive phase in patients with PV. Objectives To analyse the epitope profiles of anti-Dsg1 antibodies across the different activity stages of PF. Methods We evaluated five patients with PF who retained high serum levels of anti-Dsg1 antibodies in the inactive phase. ...
Desmosomes are composed of two major transmembrane proteins, desmoglein (Dsg) and desmocollin (. Plakophilins 2a and 2b. Function. Desmosomes are cell-cell adhesion complexes that provide mechanical integrity to keratinocytes by linking to keratin intermediate filaments. Protection against pemphigus foliaceus by desmoglein 3 in neonates. A, 35 S-labeled wild type human Dsg1 cytoplasmic tail was incubated with control buffer or increasing concentrations of multiple recombinant caspases for 1 h at 37°C. Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family. Fluorescein isothiocyanate-conjugated goat anti-mouse or goat anti-rabbit antibodies (Kirkegaard and Perry Laboratories, Gaithersburg, MD) and rhodamine-conjugated goat anti-rabbit antibody (BioSource, Camarillo, CA) were used. During low-level expression of desmoglein 3ΔEC in transduced HaCaT cells, keratin insertion at cell-cell contact sites was only partially ...
This page includes the following topics and synonyms: Pemphigus Foliaceus, Superficial Pemphigus, Pemphigus erythematosus, Senear-Usher Syndrome, Fogo selvagem, Pemphigus herpetiformis.
Pemphigus foliaceus is one of the most common autoimmune diseases in dogs, leading to autoantibodies to desmoglein I and finally to pustule and crust formation. Immunosuppressive therapy is mandatory in this disease - but does it always have to be given for the rest of the life? An interesting, rarely discussed question!
We evaluated the effectiveness of mizoribine, a newly developed immunosuppressive agent, as an adjuvant therapy in the treatment of both pemphigus vulgaris and pemphigus foliaceus. Eleven pemphigus patients (eight pemphigus vulgaris and three pemphigus foliaceus) received the combination therapy of prednisolone and mizoribine. Complete remission was observed in three of the eight patients with pemphigus vulgaris and in one of the three patients with pemphigus foliaceus. The four patients with complete remission had a rapid clinical response and achieved remission at a median of 11.8 months. Partial remission was achieved in two of the three patients with pemphigus foliaceus. The median time to achieve partial remission was 16.0 months. Six (55.6%) of the 11 patients with pemphigus had complete or partial remission and were able to taper their prednisolone. The cumulative probability of having a complete remission was 64.3% at 19 months of follow-up using Kaplan-Meier analysis. The effectiveness ...
Pemphigus foliaceus, the most common autoimmune skin condition in dogs and cats, is characterized by pustules, erosions, and crusts. In this article, we focus on the diagnosis and treatment of pemphigus foliaceus in dogs and cats.. The signs of an attack on keratinocyte adhesion structures are clinically evident. When the tight bonds between superficial keratinocytes are affected, it manifests as vesicles and pustules. When the tight bonds between basilar keratinocytes and the skins basement membrane are affected, it manifests as bullae (large blisters) and ulcers.. In pemphigus foliaceus in people, the most common target of autoantibodies is the desmoglein 1 (DSG1) glycoprotein in the desmosome. The autoantibody response primarily involves IgG (IgG4 subclass). Initial studies in dogs with pemphigus foliaceus only rarely detected an IgG autoantibody response, but more recent work using different substrates in indirect immunofluorescence testing confirms that IgG autoantibodies are important in ...
Formalin pigment shares many properties with hemozoin. In this case, the authors recommend the use of neutral buffered formalin to prevent the formation of formalin pigment especially after long periods of fixation when taking biopsies under extreme temperature and environmental humidity.
Pemphigus foliaceus is a rare autoimmune disorder that causes people to have skin that blisters easily and develops crusty, scaly...
PepTivator® Desmoglein is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the pemphigus vulgaris antigen Desmoglein-3 (UniProt ID: P32926) . In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. - Deutschland
PepTivator® Desmoglein is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the pemphigus vulgaris antigen Desmoglein-3 (UniProt ID: P32926) . In vitro stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells. - Lëtzebuerg
TY - JOUR. T1 - Detection of autoantibodies against the calcium-dependent epitopes of desmoglein 3 by ethylenediaminetetraacetic acid-treated enzyme-linked immunosorbent assay with mammalian cell expression system. AU - Kamiya, Koji. AU - Aoyama, Yumi. AU - Yamaguchi, Mari. AU - Tokura, Yoshiki. AU - Iwatsuki, Keiji. PY - 2015/8/1. Y1 - 2015/8/1. UR - http://www.scopus.com/inward/record.url?scp=84937979215&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84937979215&partnerID=8YFLogxK. U2 - 10.1111/1346-8138.12906. DO - 10.1111/1346-8138.12906. M3 - Letter. C2 - 25917237. AN - SCOPUS:84937979215. VL - 42. SP - 825. EP - 827. JO - Journal of Dermatology. JF - Journal of Dermatology. SN - 0385-2407. IS - 8. ER - ...
TY - JOUR. T1 - The Role of Desmoglein 1 in Gap Junction Turnover Revealed through the Study of SAM Syndrome. AU - Cohen-Barak, Eran. AU - Godsel, Lisa M.. AU - Koetsier, Jennifer L.. AU - Hegazy, Marihan. AU - Kushnir-Grinbaum, Daniella. AU - Hammad, Helwe. AU - Danial-Farran, Nada. AU - Harmon, Robert. AU - Khayat, Morad. AU - Bochner, Ron. AU - Peled, Alon. AU - Rozenblat, Mati. AU - Krausz, Judit. AU - Sarig, Ofer. AU - Johnson, Jodi L.. AU - Ziv, Michael. AU - Shalev, Stavit A.. AU - Sprecher, Eli. AU - Green, Kathleen J.. N1 - Funding Information: This work was supported by the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases R01 AR041836 and National Institutes of Health R37 AR43380 to KJG, and by a Fulbright postdoctoral fellowship grant to ECB. MH was supported by the National Institutes of Health T32 Training Grant (T32 CA009560). Additional support was provided by the JL Mayberry endowment to KJG. We acknowledge support and materials ...
Desmoglein 3 antibody [3G133] (desmoglein 3) for ICC/IF, IHC-P, IP, WB. Anti-Desmoglein 3 mAb (GTX14416) is tested in Human samples. 100% Ab-Assurance.
Polyclonal antibody for Desmoglein 3/DSG3 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. Desmoglein 3/DSG3 information: Molecular Weight: 107533 MW; Subcellular Localization: Cell membrane ; Single-pass type I
Order monoclonal and polyclonal Desmoglein 3 antibodies for many applications. Selected quality suppliers for anti-Desmoglein 3 antibodies.
1. Pemphigus Foliaceus. Secondly, they can be caused by Pemphigus Foliaceus which is a disorder that results in blisters on the mucous membrane.. 2. Constant trauma. Do not forget also that trauma on the nose has the potential to cause this problem. One example could be blowing it too hard in such a way that there is a rupture in the blood capillaries that can lead to small ulcers.. 3. Infections such as bacteria. Infections like bacterial infection can also this problem. It is important to understand that the nasal passages would normally act as a shield against things like bacteria and dust in the air we breathe. These are well trapped in the mucus on the nose hairs; however, when there is a crack inside the nasal passages, it is possible for the bacteria to cause some infections inside the lining which could cause these nose sores.. Staphylococcus bacteria are known to be one of the most common problems for nasal sores. In fact, the bacteria which are sometimes referred to as staph is ...
The rest of December went well, eye healing up and skin was getting better. After the surgery Otis started to gain weight and muscle. I think the eye was bothering him for much longer than we knew. Somewhere in the back of my mind I crossed my fingers that the tumor had caused all of…
Principal Investigator:ISHIKO Akira, Project Period (FY):2006 - 2007, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Dermatology
The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth.. This mechanism can be contrasted with innate immunity in that pathogen-specific receptors of innate immunity are encoded in the germline, whereas pathogen-specific receptors of acquired immunity are acquired through a somatic expression process during the lifetime of the organism. Both immune systems are adaptive in the physiological and evolutionary sense of allowing the organism to adapt to changing external circumstances. Both can be maladaptive in sense that over-activity can lead to pathological inflammation and/or autoimmunity. The pathogen-receptors of innate and acquired immune mechanisms are both specific, but the specificities of the former have evolved over evolutionary time for highly conserved molecular features of the microbial world, while the specificities ...
Melanoma arises from transformation of melanocytes (MCs) in the basal layer of the epidermis where they are surrounded by keratinocytes (KCs). While research ha...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Rabbit recombinant monoclonal Desmoglein 1 antibody [EPR6766(B)] validated for WB, IHC and tested in Human, Mouse and Rat. Referenced in 1 publication and 4…
Purchase Recombinant Human Desmoglein-1(DSG1),partial. It is produced in in vitro E.coli expression system. High purity. Good price.
Complete information for DSG1 gene (Protein Coding), Desmoglein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Gene target information for Dsg3 - desmoglein 3 (house mouse). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
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Plakoglobin interacts with both classical and desmosomal cadherins. It is closely related to Drosophila aramadillo (arm) gene product; arm acts in the wingless (wg)-signaling pathway to establish segment polarity. In Xenopus, homologs of wg--i.e., wnts, can produce anterior axis duplications by inducing dorsal mesoderm. Studies in Drosophila suggest that wnt acts by increasing the level of cytoplasmic armadillo protein (arm). To test whether simply increasing the level of plakoglobin mimics the effects of exogenous wnts in Xenopus, we injected fertilized eggs with RNA encoding an epitope-tagged form of plakoglobin; this induced both early radial gastrulation and anterior axis duplication. Exogenous plakoglobin accumulates in the nuclei of embryonic cells. Plakoglobin binds to the tail domain of the desmosomal cadherin desmoglein 1. When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA, both the dorsalizing effect and nuclear accumulation of plakoglobin were ...
In patients with pemphigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3) cause loss of cell-cell adhesion of keratinocytes in the basal and immediate suprabasal layers of stratified squamous epithelia. The pathology, at least partially, may depend on protease release from keratinocytes, but might also result from antibodies interfering with an adhesion function of Dsg3. However, a direct role of desmogleins in cell adhesion has not been shown. To test whether Dsg3 mediates adhesion, we genetically engineered mice with a targeted disruption of the DSG3 gene. DSG3 -/- mice had no DSG3 mRNA by RNase protection assay and no Dsg3 protein by immunofluorescence (IF) and immunoblots. These mice were normal at birth, but by 8-10 d weighed less than DSG3 +/- or +/+ littermates, and at around day 18 were grossly runted. We speculated that oral lesions (typical in PV patients) might be inhibiting food intake, causing this runting. Indeed, oropharyngeal biopsies showed erosions with histology
Desmoglein 2 (Dsg2) is a Ca(2+)-dependent adhesion molecule of desmosomes and is synthesized in all desmosome-bearing tissues from their earliest appearance onward. To examine the function of Dsg2, its gene was inactivated by homologous recombination in embryonal stem (ES) cells for the generation of knockout mice. DSG2 -/- mice and a considerable number of DSG2 +/- mice died at or shortly after implantation. On the other hand, DSG2 -/- blastocysts developed an apparently normal trophectoderm layer, the first tissue known to produce desmosomes, and hatched properly. Immunofluorescence analyses of these blastocysts showed, however, that the distribution of the desmosomal plaque protein desmoplakin was disturbed, whereas the adherens junction proteins E-cadherin and beta-catenin appeared to be unaffected. Unexpectedly, we found that Dsg2 seems to be essential for the inner cell mass and the ES cell population derived there from. We present evidence that Dsg2, which is located in desmoplakin-negative wild
Indication: adult patients with pemphigus vulgaris and pemphigus foliaceus.. SAMEP recommendation: To list rituximab on the statewide high cost medicines formulary for adult patients with pemphigus vulgaris and pemphigus foliaceus who are refractory to conventional immunosuppression or who are steroid-dependent.. Rationale: Rituximab, in combination with short term prednisone, can induce remission in newly diagnosed pemphigus patients with a lower total prednisone dose than if relying on prednisone alone. The majority of patients treated with rituximab experienced at least one episode of complete remission off therapy (89%) at two years as compared to approximately a third (34%) of patients only receiving prednisone.. The rate of relapse at 24 months also favoured rituximab treated patients (24% versus 45%) and fewer patients in the rituximab arm had active lesions at 24 months or had no lesions but remained on significant prednisone doses (11% versus 64%). Rituximab has a steroid sparing effect ...
Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result
Tong, J.C.,Tan, T.W.,Ranganathan, S.,Sinha, A.A. (2006). Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris. BMC Bioinformatics 7 (SUPPL.5). ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2105-7-S5-S7 ...
尋常性天疱瘡に検出されるデスモグレイン3のカルシウム非依存性構造に対する抗体とその病因性への関 ...
The cryo-electron microscopy (cryo-EM) structure of the complex between the trimeric human adenovirus B serotype 3 fibre knob and human desmoglein 2 fragments containing cadherin domains EC2 and EC3 has been published, showing 3:1 and 3:2 complexes. Here, the crystal structure determined at 4.5 Å resolution is presented with one EC2-EC3 desmoglein fragment bound per fibre knob monomer in...
Authors: Scarsella L, Pollmann R, Amber KT Abstract Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against epidermal cadherins, such as desmoglein (Dsg)1 and Dsg3, lead to the development of blisters and erosions on the skin and the mucous membranes. Autoreactive CD4+ T cells are essential for the induction and perpetuation of the disease by interaction with B cells producing autoantibodies. PV has a strong genetic association with certain human leucocyte antigen (HLA) alleles with being HLA-DRB1*04:02 and DQB1*05:03 the most prevalent in patients. Recently, genome-wide associa ...
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Pemphigus foliaceus, calcinosis cutis and hepatocutaneous syndrome are the 3 strange and unusual skin diseases that can plague pets.
Are You Confident of the Diagnosis? What you should be alert for in the history Characteristic findings on physical examination Expected results of diagnostic studies [histopathology, serologic tests, genetic tests, imaging studies] Diagnosis confirmation [Describe those conditions in the differential diagnosis that may reasonably mimic the diagnosis and explain their distinction] Pemphigus foliaceus (PF) and…. ...
In the current study, we found that the function of AH associated DE gene DSG1 (up-regulated in cows fed AH, compared with those fed CS and RS) was enriched under the ion-binding function as well as was associated with tight junctions. This gene encodes a member of the desmoglein protein subfamily which has been reported to be involved in epithelial cell proliferation in bovine epidermis and tongue papillae [36]. It has been speculated that ion binding in the rumen may be attributed to the Na+-K--ATPase transport system for nutrient absorption [37]. Na+-K- pumps are predominately localized to the innermost living cell layers of the stratum spinosum and the stratum germinativum [38]. Increased VFAs absorption by greater Na+-K--ATPase activity could prevent possible disturbance of epithelial functions (transport and barrier functions) [39]. The higher amount of VFAs and the greater expression of DSG1 in cows fed AH diet indicates likely more nutrient transport through RE when animals fed AH ...
100 Way - Campaign For Musical Destruction (1) 14 BIS (1) 1853 (1) 1990 Projeto com músicos das bandas LEVIAETHAN (1) 1999) (1) 2010) (1) 2012) (1) 215DB (1) 3 (1) 365 (1) 6SICKS6 (1) 7 DIAS DE MASSACRE (1) A BARCA DO SOL (1) A BOLHA (1) A CASA CAIU (2) A CHAVE (1) A CHAVE DO SOL (2) A FALANGE (1) A FERRO E FOGO VOLUME 7 (1) A RED NIGHTMARE (1) A SEASON IN HELL (1) A SORROWFUL DREAM (1) A TRIBO (1) A TRIBO (PSICODELIA) (1) A Tribute to the Plague (1) A TRIGGER TO FORGET (1) AAMON HAMMER (1) ABADOM (1) abasbaron (1) ABATE (1) ABATE MACABRO (1) ABHOR (1) ABHORRENCE (3) ABHORRENT (1) ABIOSI (1) Abluesados (1) ABOMINADOR (1) Abomination (1) ABOMINATTION (1) ABOMINATUS (2) ABOMYDOGS (1) ABRASION (1) ABRAVANEL (1) ABRUPTOR (1) ABSKE FIDES (1) Abske Fides - Abske Fides (2012) (1) ABSOLUTE DISGRACE (2) ABUSO SONORO (1) ABUSO VERBAL (1) ABUTRE (1) ABYSINTHO (1) ABYSMAL FOREST (VÍDEO) (1) AÇÃO DIRETA (2) AÇÃO LIBERTÁRIA (1) Acceptus Noctifer - Amores De Ofício (2009) (1) ACE 4 TRAYS (1) Acesso ...
100 Way - Campaign For Musical Destruction (1) 14 BIS (1) 1853 (1) 1990 Projeto com músicos das bandas LEVIAETHAN (1) 1999) (1) 2010) (1) 2012) (1) 215DB (1) 3 (1) 365 (1) 6SICKS6 (1) 7 DIAS DE MASSACRE (1) A BARCA DO SOL (1) A BOLHA (1) A CASA CAIU (2) A CHAVE (1) A CHAVE DO SOL (2) A FALANGE (1) A FERRO E FOGO VOLUME 7 (1) A RED NIGHTMARE (1) A SEASON IN HELL (1) A SORROWFUL DREAM (1) A TRIBO (1) A TRIBO (PSICODELIA) (1) A Tribute to the Plague (1) A TRIGGER TO FORGET (1) AAMON HAMMER (1) ABADOM (1) abasbaron (1) ABATE (1) ABATE MACABRO (1) ABHOR (1) ABHORRENCE (3) ABHORRENT (1) ABIOSI (1) Abluesados (1) ABOMINADOR (1) Abomination (1) ABOMINATTION (1) ABOMINATUS (2) ABOMYDOGS (1) ABRASION (1) ABRAVANEL (1) ABRUPTOR (1) ABSKE FIDES (1) Abske Fides - Abske Fides (2012) (1) ABSOLUTE DISGRACE (2) ABUSO SONORO (1) ABUSO VERBAL (1) ABUTRE (1) ABYSINTHO (1) ABYSMAL FOREST (VÍDEO) (1) AÇÃO DIRETA (2) AÇÃO LIBERTÁRIA (1) Acceptus Noctifer - Amores De Ofício (2009) (1) ACE 4 TRAYS (1) Acesso ...
TY - JOUR. T1 - Neonatal pemphigus vulgaris. T2 - IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. AU - Parlowsky, Thomas. AU - Welzel, Julia. AU - Amagai, Masayuki. AU - Zillikens, Detlef. AU - Wygold, Thorsten. PY - 2003/4/1. Y1 - 2003/4/1. N2 - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.. AB - We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy ...
TY - JOUR. T1 - The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C. AU - Denning, Mitchell F.. AU - Guy, Sandra G.. AU - Ellerbroek, Shawn M.. AU - Norvell, Suzanne M.. AU - Kowalczyk, Andrew P.. AU - Green, Kathleen J.. PY - 1998/2/25. Y1 - 1998/2/25. N2 - Three desmoglein (Dsg) isoforms are expressed in a differentiation- specific fashion in the epidermis, with Dsg2 being basal, Dsg3 (pemphigus vulgaris antigen) basal and spinous, and Dsg1 (pemphigus foliaceus antigen) predominately granular. To better understand the mechanism(s) regulating Dsg isoform expression, we examined the expression pattern of Dsg1, Dsg2, and Dsg3 in normal human epidermal keratinocytes (NHEKs), the immortalized, nontumorigenic HaCaT cell line, and several squamous cell carcinoma cell lines (SCC-9, SCC-12F, SCC-13, and SCC-25). In all cells, the accumulation of high Dsg protein levels required calcium and was not observed in low calcium (0.050.07 ...
Background: The use of saliva for the diagnosis of pemphigus vulgaris (PV) by enzyme-linked immunosorbent assay (ELISA) using desmoglein (Dsg)3 antigen has not been extensively documented, nor has the detection of serum IgA antibodies to Dsg3. Objectives: (i) To establish whether whole saliva might provide a suitable alternative to serum for diagnosing and monitoring PV; (ii) to investigate whether anti-Dsg3 IgA antibodies can be detected in serum and saliva and (iii) to establish whether there is an association between serum or saliva anti-Dsg3 antibodies and disease severity. Methods: Precoated Dsg3 ELISA plates were used to test serum and/or saliva for IgG and IgA antibodies. Matched serum and whole saliva samples were collected from 23 patients with PV, 17 healthy subjects and 19 disease controls. All patients with PV, disease controls and six healthy controls provided matched parotid saliva. Results: Whole saliva IgG antibodies to Dsg3 were detected in 14 of 23 patients (61%) and serum IgG ...
Define pemphigus vulgaris. pemphigus vulgaris synonyms, pemphigus vulgaris pronunciation, pemphigus vulgaris translation, English dictionary definition of pemphigus vulgaris. n. Any of several acute or chronic skin diseases characterized by groups of itching blisters. pem′phi·gous adj. n pathol any of a group of blistering skin...
Background:Pemphigus is a life-threatening, autoimmune blistering disease, mediated by IgG autoantibodies. The aim of our study was to assess the usefulness of a new enzyme-linked immunosorbent assay (ELISA) in detecting circulating pemphigus autoantibodies, and to compare its sensitivity and specificity with the indirect immunofluorescence (IIF) test. We also established the frequency of occurrence of pemphigus autoantibodies in relatives of our patients.Material/Methods:IIF and ELISA tests were performed in 24 patients with pemphigus vulgaris, 13 with pemphigus foliaceus, 56 healthy relatives, and 50 controls, selected according to sex and age.Results:The obtained results revealed high specificity and sensitivity of ELISA, comparable to the IIF test, especially in patients who were in the active stage of the disease. We also showed that the profile of anti-Dsg 1 and/or anti-Dsg 3 autoantibodies is associated with the clinical variant of pemphigus. The frequency of occurrence of pemphigus ...
Desmosomes are molecular complexes of cell adhesion proteins and linking proteins that attach the cell surface adhesion proteins to intracellularkeratin cytoskeletal filaments.. The cell adhesion proteins of the desmosome, desmoglein and desmocollin, are members of the cadherin family of cell adhesion molecules. They aretransmembrane proteins that bridge the space between adjacent epithelial cellsby way of homophilic binding of their extracellular domains to other desmosomal cadherins on the adjacent cell. Both have five extracellular domains, and have calcium-binding motifs.. The extracellular domain of the desmosome is called the Extracellular Core Domain (ECD) or the Desmoglea, and is bisected by an electron-dense midline where the desmoglein and desmocollin proteins bind to each other. These proteins can bind in a W, S, or λ manner.. On the cytoplasmic side of the plasma membrane, there are two dense structures called the Outer Dense Plaque (ODP) and the Inner Dense Plaque (IDP). These are ...
A prospective study of laboratory findings in dapsone treated patients with Pemphigus vulgaris and foliaceus, Mona Afrasiabi, Shabnam Esmaeilinejad, Vahid Asgary, Reza Ahangari Coh
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Kirov State Medical University. The article describes modern views on predisposing factors, characteristics of the immunological changes and link with the histocompatibility antigens HLA, the role of circulating autoantibodies in the pathogenesis of the disease in patients with pemphigus vulgaris. Described 2 cases of clinical observations and vulgar pemphigus, foliaceous pemphigus, accompanied by concomitant pathology of internal organs in the form of cardiovascular system pathology, chronic iron deficiency anemia, diffuse and knotty changes of the thyroid gland. The good effect of etiotropic, pathogenetic and symptomatic therapy in accordance with the standards of specialized medical care in moderate-to-severe pemphigus. ...
Pemphigus describes a group of autoimmune blistering diseases that involve the epidermal surfaces of the skin, mucosa, or both. There are 3 broad categories: pemphigus vulgaris (PV), pemphigus foliaceus (PF), and paraneoplastic pemphigus (PNP). Pemphigus is mediated by an autoantibody that binds a specific component of the desmosomal plaque. The desmosomal plaque holds the keratinocytes of the skin and mucosa together. ...
Azathioprin; Cyclophosphamid; Pemphigus; Pulstherapie Summary Background: Pemphigus is a potentially life-threatening autoimmune blistering skin disease usually treated with high-dose corticosteroids in combination with immunosuppressive drugs. In a multicenter, prospectively randomized study we compared efficacy and side effects of a dexamethasone-cyclophosphamide (D/C) pulse therapy with a methylprednisolone-azathioprine (M/A) therapy in 22,patients with newly diagnosed pemphigus vulgaris and pemphigus foliaceus. Patients and methods: The 11,patients of the M/A group were treated with daily doses of methylprednisolone (initially 2,mg/kg body weight) and azathioprine (2,,,2,5,mg/kg body weight) which were subsequently tapered. D/C pulse therapy in 11,patients consisted of intravenous administration of 100,mg dexamethasone/d on 3 consecutive days along with cyclophosphamide (500,mg) on day one. Pulses were initially repeated every 2,,,4 weeks and then at increasing intervals. In between the ...
ACANTHOLYSIS: Review the definition, meaning, pronunciation, explanation, synonyms, and antonyms of the term ACANTHOLYSIS in the Online Dictionary. What is a 12 letter word that starts with A?
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
The purpose of this study is to explore a new medication for the skin disease termed pemphigus. Our specific aim is to determine whether the use of sirolimus will allow for a decrease in the dosage or possibly eliminate the need for corticosteroids, which so far is the only type of drug that can control this disease.. Pemphigus is an autoimmune disease characterized by blistering, caused by autoantibodies against certain cells in the skin. This disease most commonly occurs in individuals ages 50 and older, and it presents as painful shallow erosions and/or blisters in the mouth and/or skin. Pemphigus is very painful and uncomfortable, associated with impaired quality of life and significant morbidity. Severe or untreated cases of pemphigus can become fatal if the involved surface area becomes large enough to cause dehydration and/or infection. The first line of therapy, and the standard of care, for pemphigus remain to be systemic corticosteroids. However, corticosteroids have many known side ...
Fig1: Western blot analysis of DSG3 on human DSG3 recombinant protein using anti-DSG3 antibody at 1/1,000 dilution. Fig2: Western blot analysis of DSG3 on HEK293 (1) and DSG3-hIgGFc transfected HEK293 (2) cell lysate using anti-DSG3 antibody at 1/1,000 dilution. Fig3: Western blot analysis of DSG3 on A431 cell lysate using anti-DSG3 antibody at 1/1,000 dilution. Bon Opus Cat. #BA112704
Cancer Therapy Advisor provides dermatologists with the latest dermatology conditions, procedures and guides for different surgical and non surgical conditions. Visit often for updates and new information.
RESULTS: Thirty-five patients were included. Clinical phenotypes were: mucosal in 17 patients; mucous-cutaneous in 11; and cutaneous in 7. The status of anti-Dsg1 autoantibodies was significantly related to the cutaneous and mucous-cutaneous phenotypes both at diagnosis and after 6 months. The status of anti-Dsg3 autoantibodies was significantly related to the mucosal and mucous-cutaneous phenotypes only at first evaluation. No significant correlations were found between disease activity and the status of autoantibodies. No significant variations of autoantibody levels (between first and second sample) were found with regard to different therapies, except for the variation of anti-Dsg1 autoantibodies in one patient treated with systemic steroids and methotrexate ...
Chlorambucil is a very popular drug in feline medicine, especially used in the treatment of autoimmune diseases like pemphigus foliaceus or in neoplastic conditions like lymphoma. Neurotoxicity as a common side effect like in human medicine has never been described - until this cat was treated with chlorambucil.
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Download Pemphigus Disease. Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The name is derived from the Greek root pemphix meaning...
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ESSE BLOG É UMA EXTENSÃO DO A FERRO E FOGO E DO ATITUDE UNDERGROUND BEBEDOURO.POR ISSO PARECE ABANDONADO. AOS POUCOS CUIDAREI MELHORD ...
ESSE BLOG É UMA EXTENSÃO DO A FERRO E FOGO E DO ATITUDE UNDERGROUND BEBEDOURO.POR ISSO PARECE ABANDONADO. AOS POUCOS CUIDAREI MELHORD ...
Segundo a resolu o WHA41.28,da Assembleia Mundial da Sa de realizada em 1988, iniciou-se o programa global de erradica o da poliomielite. V rios progressos t m sido alcan ados como a inexist ncia de casos pelo poliov rus selvagem tipo 2 desde 1999 e pelo poliov rus selvagem tipo3 desde 11 de novembro de 20121. Outro momento marcante para a erradica o global da poliomielite foi 68 Assembleia Mundial da Sa de realizada no per odo de 18 a 26 de maio de 2015 em Genebra, que reuniu autoridades sanit rias de 194 pa ses. Neste evento, foi definida a Resolu o WHA68.3, na qual constam novos acordos sobre a erradica o global da poliomielite, refor ando que a erradica o s poder ser alcan ada por meio do compromisso global, que foi endossado pelos pa ses membros2. Os acordos definidos na Resolu o WHA68.3s o frutos das conclus es da reuni o do Grupo Consultor Estrat gico de Especialistas (SAGE) da Organiza o Mundial da Sa de (OMS), realizada no per odo 21 a 23 de outubro de 2014. Destacaram que os ...
What is pemphigus? It is a disease where the immune system attacks healthy cells resulting in blisters. Learn the phemigus types, treatment & more.
RESUMO Retardantes de fogo são eficazes em combater incêndios florestais, contudo, suas implicações ambientais, principalmente quanto à vegetação, precisam ser melhor esclarecidas. Neste trabalho, objetivouse avaliar os efeitos de retardantes de fogo sobre o crescimento inicial de Schizolobium amazonicum. Os tratamentos consistiram em aplicações via substrato e foliar de concentrações dos retardantes de fogo: Phos-Chek WD-881® (0; 3,00; 6,00; 8,00 e 10,00 mL L-1); Hold Fire® (0; 7,00; 9,00; 12,00; e 15,00 mL L-1 ) e do polímero hidroretentor Nutrigel® usado como retardante alternativo (0; 0,25; 0,50; 0,75 e 1,00 g L-1). Para avaliação dos efeitos realizaram-se análises de crescimento, com 10 repetições por tratamento. Compararamse as médias pelo Teste de Tukey (p,0,05) conforme significância da análise de variância A concentração de 10,00 mL L-1 de Phos-Chek WD881 via foliar proporcionou incrementos na área foliar (71%) e altura (18%) das mudas. No decorrer do tempo, a ...
AUTOOL 7 Speed DSG Clutch Installer Remover Dual-clutch Transmission Tool Kit for VAG VW Audi DSG T10373 T10376 T10323 1. [Widely Use]: AUTOOL DSG gearbox dual-clutch disassembly toolset for VAG, required for repairing the clutch unit, for the quick, uncomplicated repair of the clutch unit on DSG gearboxes. 2. [Suitabl
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