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ATC code R02 Throat preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the WHO for the classification of drugs and other medical products. Subgroup R02 is part of the anatomical group R Respiratory system. Codes for veterinary use (ATCvet codes) can be created by placing the letter Q in front of the human ATC code: for example, QR02. National issues of the ATC classification may include additional codes not present in this list, which follows the WHO version. R02AA01 Ambazone R02AA02 Dequalinium R02AA03 Dichlorobenzyl alcohol R02AA05 Chlorhexidine R02AA06 Cetylpyridinium R02AA09 Benzethonium R02AA10 Myristyl-benzalkonium R02AA11 Chlorquinaldol R02AA12 Hexylresorcinol R02AA13 Acriflavinium chloride R02AA14 Oxyquinoline R02AA15 Povidone-iodine R02AA16 Benzalkonium R02AA17 Cetrimonium R02AA18 Hexamidine R02AA19 Phenol R02AA20 Various R02AA21 Octenidine R02AB01 Neomycin R02AB02 Tyrothricin R02AB03 ...

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TY - JOUR. T1 - Reliability and Validity of the Devereux Early Childhood Assessment (DECA) as a Function of Parent and Teacher Ratings. AU - Barbu, Otilia C.. AU - Levine-Donnerstein, Deborah. AU - Marx, Ronald W.. AU - Yaden, David B.. PY - 2013/10/1. Y1 - 2013/10/1. N2 - This study examined reliability and validity of the Devereux Early Childhood Assessment (DECA), based on samples of parents and teachers ratings of 1,145 entering kindergartners in the Southwest. Confirmatory factor analysis showed that DECA presented good reliability and validity for manifest variables, corroborating previous findings. Three latent variables (initiative, self-control, and attachment) substantiated reliability estimates but showed insufficient discriminant validity because of multicollinearity among latent variables. We recommended caution in interpreting and applying results of DECA assessments in practice because of a lack of discriminant validity. Thus, these findings addressed the need for researchers, ...

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TY - JOUR. T1 - Enhanced ADCC and NK cell activation of an anticarcinoma bispecific antibody by genetic insertion of a modified IL-15 cross-linker. AU - Schmohl, Joerg U.. AU - Felices, Martin. AU - Taras, Elizabeth. AU - Miller, Jeff S.. AU - Vallera, Daniel A.. N1 - Funding Information: We acknowledge the excellent technical assistance of Deborah Todhunter, Andy Sicheneder, Sami Chu, and Seunguk Oh. This work was supported in part by the US Public Health Service Grants R01-CA36725, R01-CA72669, P01-CA65493, P01-CA111412 and R35 CA197292 awarded by the NCI and the NIAID, DHHS. It was also supported by an NIH Research Evaluation and Commercialization Hub (REACH) Award (U01), the Mayo Partnership Award, the Lion Fund, William Lawrence and Blanche Hughes Fund, the Randy Shaver Foundation, the Atwater Cancer Drug Development Award, a CETI translational award from the University of Minnesota Masonic Cancer Center (D.A.V.) and the Deutsche Krebshilfe (111548) (J.U.S.). D.A.V. and J.S.M. are members ...

Understanding of interactions among molecules is essential to elucidate the binding of pharmaceuticals on receptors, the mechanism of protein folding and self-assembling of organic molecules. While interactions between two aromatic molecules have been examined extensively, little is known about the interactions between two antiaromatic molecules. Theoretical investigations have predicted that antiaromatic molecules should be stabilized when they stack with each other by attractive intermolecular interactions. Here, we report the synthesis of a cyclophane, in which two antiaromatic porphyrin moieties adopt a stacked face-to-face geometry with a distance shorter than the sum of the van der Waals radii of the atoms involved. The aromaticity in this cyclophane has been examined experimentally and theoretically. This cyclophane exhibits three-dimensional spatial current channels between the two subunits, which corroborates the existence of attractive interactions between two antiaromatic π-systems. Little

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Our previous studies demonstrate that PKC-β, but not PKC-α, is associated with the outer surface of melanosomes (Park et al., 1999), consistent with the known location of this cytoplasmic enzyme (Nishizuka, 1992). Brief trypsinization of melanosomes removed PKC-β (Park et al., 1999). However, the mechanism by which activated PKC-β associates with melanosomes and phosphorylates tyrosinase remained to be elucidated. Our present results demonstrate that RACK-I on melanosomes anchors activated PKC-β, allowing the kinase to phosphorylate tyrosinase. The localization of RACK-I to melanosomes is strongly suggested by its co-localization, as demonstrated by confocal microscopy, with tyrosinase, a transmembrane protein known to be detected at the melanosome surface (Jimbow and Fitzpatrick, 1973; Maul and Brumbaugh, 1971). However, further support for this localization is provided by the readily detectable level of RACK-I in the purified melanosome preparation, as demonstrated by immunoblotting. The ...

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Rolf Gleiter is professor of chemistry at the Universität Heidelberg. He studied chemistry and finished his doctoral thesis under the supervision of F. Effenberger in Stuttgart in 1964. From 1965 - 1968 he did postdoctoral work in the US, one year with P. v. R. Schleyer at Princeton and two years with R. Hoffmann at Cornell. He completed his habilitation with E. Heilbronner in Basel in 1972. In 1973 he moved as full professor to TU Darmstadt. In 1979 he took his present position. R. Gleiter is interested in intra- and intermolecular bonding properties by synthesizing model systems and investigation of their interactions by physical measurements supported by quantum chemical calculations ...

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