Dents disease (or Dent disease) is a rare X-linked recessive inherited condition that affects the proximal renal tubules of the kidney. It is one cause of Fanconi syndrome, and is characterized by tubular proteinuria, excess calcium in the urine, formation of calcium kidney stones, nephrocalcinosis, and chronic kidney failure. "Dents disease" is often used to describe an entire group of familial disorders, including X-linked recessive nephrolithiasis with kidney failure, X-linked recessive hypophosphatemic rickets, and both Japanese and idiopathic low-molecular-weight proteinuria. About 60% of patients have mutations in the CLCN5 gene (Dent 1), which encodes a kidney-specific chloride/proton antiporter, and 15% of patients have mutations in the OCRL1 gene (Dent 2). Dents disease often produces the following signs and symptoms: Extreme thirst combined with dehydration, which leads to frequent urination Nephrolithiasis (kidney stones) Hypercalciuria (high urine calcium - >300 mg/d or >4 mg/kg ...
Dents disease is an X-linked recessive proximal tubulopathy characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis and progressive renal failure. To the best of our knowledge, this is only the third report on the use of growth hormone therapy in a child with poor growth associated with Dents disease. We report on a 7-year-old Montenegrin boy with proteinuria, hypercalciuria, nephrocalcinosis, rickets and short stature with unimpaired growth hormone secretion. A molecular genetic analysis showed S244L substitution on the CLCN5 gene. After two years of conventional treatment with hydrochlorothiazide, laboratory tests revealed more prominent proteinuria, mild hypophosphatemia, increased values of alkaline phosphatase and features of rickets. Phosphate salts, calcitriol, potassium citrate and growth hormone were included in the therapy. After three years of therapy, his adjusted parental stature was 1.53 standard deviations higher than at the initiation of
BACKGROUND: Dents disease, an X-linked renal tubular disorder, is characterized by low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, and progressive renal failure. Dents disease results from mutations of the voltage-gated chloride channel CLC-5. METHODS: We studied the effect of zero and high citrate diet on renal function of ClC-5 knockout mice and wild-type mice. The mice were placed in metabolic cages from which the urine was collected. Mice were sacrificed to obtain serum and tissues for analysis. RESULTS: ClC-5 knockout mice fed zero or high citrate diet had significantly increased urinary calcium excretion compared with wild-type mice fed the same diets. Nine-month-old ClC-5 knockout mice on a zero citrate diet had significantly decreased glomerular filtration rate (GFR), whereas 9-month-old ClC-5 knockout mice on a high citrate diet had normal renal function. ClC-5 knockout mice fed a zero citrate diet had significantly increased tubular atrophy, ...
Autor: Tanaka, Karo et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 1999; Open Access; Titel: Characterization of novel promoter and enhancer elements of the mouse homologue of the Dent disease gene, CLCN5, implicated in X-linked hereditary nephrolithiasis|br/||br/|
O objetivo da presente tese foi determinar a prevalência, extensão e fatores associados a perdas dentárias em adolescentes. Além disso, buscou avaliar o impacto da saúde bucal na qualidade de vida desses adolescentes. Para tanto, um estudo observacional transversal com 736 estudantes sorteados aleatoriamente, na faixa dos 15- 19 anos foi conduzido. O estudo incluiu 20 escolas públicas e privadas do ensino médio da cidade de Passo Fundo/RS. Exame clínico de contagem de dentes e entrevista com questionário estruturado, que incluiu aspectos sociodemográficos, comportamentais e de saúde bucal, foi aplicado. Qualidade de vida foi aferida pela aplicação do instrumento OHIP-14. No primeiro estudo, as perdas dentárias foram analisadas em dois modelos, um com adolescentes sem extração por motivo ortodôntico, e um segundo, com todos os adolescentes com extração dentária. A prevalência de perda dentária foi de 21,1% e a média foi de 0,42 dentes por indivíduo. O primeiro pré-molar ...
Authors: Frank Schwarz, Prof Dr med dent / Kathrin Becker, Dr med dent MSc / Klaus-Dieter Bastendorf, Dr med dent / Daniele Cardaropoli, Dr, DDS / Christina Chatfield, Hygienist / Ian Dunn, Dr, BChD, MFGDP, MSc / Paul Fletcher, DDS / Johannes Einwag, Prof Dr med dent / Anna Louropoulou, DMD, MSc / Andrea Mombelli, Prof Dr med dent / Philip Ower, MSc, BDS, MGDSRCS / Pedja Pavlovic, DDS, MSc / Philipp Sahrmann, Dr med dent, MAS / Giovanni E. Salvi, Prof Dr med dent / Petra Schmage, Prof Dr med dent / Yasuko Takeuchi, DDS / Fridus Van Der Weijden, Prof Dr / Stefan Renvert, Prof, DDS, Odont Dr ...
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CLC-5, the chloride channel mutated in Dents disease, colocalizes with the proton pump in endocytotically active kidney cells ...
Some patients continuously suffer from enlarged turbinates and feel congested. Dr. Dent treats the underlying problem; however, if medical treatment does not improve the swelling there are additional options. Our goal is a clearer passageway that enables our patients to breathe easier. As North Countys leading practitioner, Dr. Dent has acquired a reputation for excellent service. Are you tired of suffering from continuous nasal drip? Why not call us so that we can speak personally? Please contact us at 760-479-2100 or email us at [email protected] ...
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I would just like to say THANK YOU SO MUCH for that post!! How reassuring~~I also, like so many others on this board, have become fixated on a few dents on my body that I am just so sure just recently appeared, and spend too much time comparing sides, and checking in different lighting, etc. I remember the first dent I found, which was on my outer calf, just threw me into a panic. I think my son wanted to have me committed that night. I was SURE at that point it was als. Since then, I have found many other dents. The funny thing is, I now notice other peoples hands, do you guys do this? For instance, I was watching a movie the other night with MIchelle Pfifer (sp?)...and anyway, a scene was showing her hands, and I remember thinking, wow, it looks like she has atrophy! Cause, she had these big dents, and things that I know Id be worried about if I saw on my hands. I know its not like being there, and lighting is a big deal and all of that, but Im just pointing out that with this illness, ...
Veggie Dent CET Chews formally known as C.E.T. Chews, are all natural, all vegetable and highly palatable. The Z shape facilitates prehension and enhances the mechanical cleaning action of the dogs teeth and gums. Regular chewing of Veggie Dent...
Pet Mountain is the online leader in discount Nylabone Nutri Dent pet products. Our online store features the widest selection, lowest prices, coupons and free shipping on many of your favorite Nylabone Nutri Dent products including chew toys, dental treats, dog chews.
Lorsquon parle des dents de lait, on ne peut pas oublier la relation entre lapex de la dent et le germe de la dent permanente qui est en train de se former. Ils peuvent provoquer des malformations, des troubles de léruption et limpact daliments dans les dents adjacentes causant la carie dentaire ou des poches parodontales, et sont souvent accompagnés de blessures des tissus mous, des lèvres et du frein lingual, ce qui peut provoquer des saignements abondants.. Instructions pour le patient ou les parents: Une bonne cicatrisation après une blessure aux dents et aux tissus oraux dépend, en grande partie dune bonne hygiène buccodentaire. Il est important que les parents comprennent limportance dune bonne hygiène pour le bon pronostic de la dent traumatisée.. ...
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Steve Jobs once remarked: "Were here to put a dent in the universe. Otherwise, why even be here?" For me, the desire to make more of a dent in the universe has prompted a professional shift from innovation strategies for business gain to ones aimed at more meaningful societal benefit … [Forbes.com ...
Authors: Michael Rosin, Dr Med Dent Habil / Christian Schwahn, Dr Med / Bernd Kordab, Dr Med Dent Habil / Corinna Konschake, Dr Med Dent / Uwe Greese, Dr Med Dent / Dirk Teichmann, Dr Med Dent / Axel Hartmann, DDS / Georg Meyer, Dr Med Dent Habil ...
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how to fix a dent in car try this awesome trick for removing from your bumper better then spending tons of hard earned money at the body shop with heat gun cost i.. ...
CtrlS is making a dent in Indias IT universe by providing world-class IT infrastructure through their Tier 4 data centers around India
Informacije o podjetju AMBULANTA ZA ORALNO KIRURGIJO DENIS HASANAGIĆ, DR.DENT.MED.SPEC. na zemljevidu najdi.si. Preverite podrobnosti ter...
Dent Doctor ========== Hey!Are you looking for a new innovative and multi specialist surgery game? Then your wait is over. We come up with a new idea, a...
I am from Houston TX and got the Kenalog shot for seasonal allergies around 7 months ago on my left arm. 2 weeks later I had a nasty dent on that s...
Stomatologia zachowawcza. Ortodoncja. Implanty i chirurgia. Protetyka. Endodoncja. Rentgenodiagnostyka. Wybielanie. Profilaktyka. Stomatologia dziecięca. Medica Dent - centrum stomatologii Wrocław
Matthew Dent is the author of this article in the Journal of Visualized Experiments: Efficient Agroinfiltration of Plants for High-level Transient Expression of Recombinant Proteins
The Pressure by Tory Dent. .Too many times have I with the sun on my back flamboyant heinously direct rocked wrung hands my shaking head refuged in a nowwet Bounty paper towel or. Page
p > dentínu tvoria väčšinu zuba . Je to ťažké , minerálna látka , ktorá sa spolieha na vlákniny , aby zostali zdravé . Ak vlákniny je vyradený zubára alebo inak umrie , dentín sa stáva krehký . Je to ťažšie , ako kosti alebo cementu , ale nie je tak ťažké , ako tenkou vrstvou smaltu , ktorá ju pokrýva . Dentín pokračuje v raste po celú dobu životnosti zuba , a opraví do určitej miery , ak zranenie . Dentín je viac žltkastý ako biela ...
¿Quiere conservar su sonrisa sin dañar el esmalte de sus uñas? Power Smile es un dentífrico súper blanqueador sin ningún producto químico ni abrasivo. Tres a
So today I just found a dent on the top of my head and I have no idea where it came from and I dont ever remember it being there before. Is it something I should be worried about? It is about an inc...
Can you pick the Drug mechanisms 4 Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by Dent2017
The Burstyn group is happy to welcome Matt Dent, a first year inorganic student, to the heme team! He comes to us from James Madison University in Virginia. Stay tuned to learn more about him on his profile page.. ...
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Can you match the common word patterns for drugs? Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by Dent2017
Visit Healthgrades for information on Dr. Robert Dent, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Stop putting stuff on it.New skin will grow in the "dent", and the skin surrounding it will blend in the the normal process of skin growth.
Affiliation:北里大学,医学部,准教授, Research Field:Kidney internal medicine,Kidney internal medicine,内科学一般, Keywords:H^+-ATPase,クロライドチャネル,Dents disease,ClC-5クロライドチャネル,sorting,ET,細胞内小胞,エンドサイトーシス,ClC-5チャネル,endocytosis, # of Research Projects:7, # of Research Products:7
AUTOMOTIVE BODY REPAIRERS repair the body sections of vehicles that have been damaged in accidents. They straighten bent bodies, remove dents, and replace crumpled parts that are beyond repair. They align damaged frames and other parts. They remove damaged sections of body panels and weld in replacement sections. They push out the less serious dents with hydraulic jacks or knock them out with hand-tools. They use plastic or solder to fill small dents, grind the hardened filler to the original shape, and then sand before painting.. ...
Aluna: Juliana Pelinsari Lana. Orientador: Prof. Dr. Martinho Campolina Rebello Horta. Programa de Pós-graduação em Odontologia da PUC Minas. RESUMO. O desenvolvimento dos implantes dentários ao longo dos últimos anos desencadeou um aumento na demanda por serviços de radiologia oral e maxilofacial. A tomografia computadorizada de feixes cônicos (TCFC) é atualmente o método de imagem mais utilizado para planejamento de implantes dentários. Os seios maxilares são estruturas anatômicas de grande importância na prática odontológica, sendo essencial o reconhecimento de suas variações anatômicas e processos patológicos em exames de imagem. O objetivo do presente estudo foi avaliar a presença de variações anatômicas e processos patológicos nos seios maxilares em tomografias computadorizadas de feixes cônicos da maxila, solicitadas para planejamento de implantes dentários. O estudo, do tipo transversal de prevalência, utilizou uma amostra de conveniência de 500 exames de TCFC ...
Prednášky pre 6.ročník „Zubné lekárstvo" zimný semester ak. Rok 2016/2017 Prednášky: 1. - 7., 9. - 13. týždeň „Maxilofaciálna chirurgia", poslucháreň Heydukova (utorok 16.30 - 18.20 hod.) 1. Dentoalveolárna chirurgia - opakovanie (anatómia dutiny ústnej, lokálna anestézia, indikácie, komplikácie lokálne, celkové, Extrakcie zubov, indikácie, technika, komplikácie lokálne, endodonticko- chirurgické ošetrenie devitálnych zubov, indikácie, technika, rtg) 2. Dentoalveolárna chirurgia - opakovanie (tretie moláre, vyšetrenie, indikácie extrakcie, asymptomatický tretí molár, technika extrakcie, chirurgická extrakcia, komplikácie, pooperačná starostlivosť) 3. Dentálna implantológia (princípy, základné typy dentálnych implantátov, chirurgická technika, indikácie, protetická sanácia defektov na dentálnych implantátoch) 4. Pacient na antiagregačnej a antikoagulačnej liečbe ( princípy a typy antiagregačnej a antikoagulačnej liečby, ...
In a 2005 Cell paper, Dent and colleagues reported that a methyl group-transferring protein called Set1 methylates the protein Dam1, which is part of a structure that assists in the orderly separation of chromosomes during cell division.. Set1 is part of a protein complex that works along with multiple regulatory factors to facilitate transcription by attaching methyl groups to a specific histone, H3, which was the only previously known target of Set1.. Dents team set out to discover the exact mechanism by which Set1 methylates Dam1. To their surprise, they found that Dam1 methylation does not depend on gene transcription, revealing news roles for proteins formerly thought to be involved only in that process.. Rather, the crucial step is the attachment of a single signaling molecule called ubiquitin to a histone protein called H2B. This event was known to direct addition of methyl groups to histone H3, but Dents work indicates it is also required for methylation of Dam1.. Communication between ...
points are only given for road traffic offences so if you claim on the rsa insurance you will have to pay the excess mine is £100 you will get the car back all shiny and as new you will not incur any points on your licence at all,hopefully you will then get the the £250 bonus.. you do NOT need to tell rsa about the points that have on your licence as they have now expired and do not count against you they have to stay on your licence for 4 years but are only active against you for 3,you should have informed rsa about them when they were active because if you had a crash you might have found yourself uninsured but the past is the past as they say ,I hope all works out for you.. y. ...
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REMARQUE : Seules les séances auxquelles étaient présentés des diapositives ou des documents (en anglais) figurent ci-dessous. Pour parcourir le programme complet, téléchargez-le ci-dessus.. ...
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Samuel Quesada raised it up to 2,200 from the hijack and Angelo Tarallo called from the big blind. The flop came :::qc:::8c:::6d and Tarallo check-called a bet of 2,200 from Quesada.. The turn brought the :::7c and Tarallo checked again. Quesada fired out another 4,500 and Tarallo still called to see the :::9s on the river. Tarallo checked for the third time and Quesada was relentless with another bet of 11,000. Tarallo thought for a minute and then made the call.. Quesada turned over :::5c:::4c for a flush and Tarallo was unable to beat it. ...
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Originally Posted by philip1 most likely you have several things against you... the worn out tie rods and poor alignment that will inevitably result will have your tires trying to go down the road
A new generation of art lovers and buyers is emerging as having faced down economic meltdown, political insecurity, a super competitive jobs market, and the hardship of getting onto the housing ladder, the offspring of the baby boomer generation are finally settling down, and thinking about what to hang on [...]
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