TY - JOUR. T1 - Homophilic Dscam Interactions Control Complex Dendrite Morphogenesis. AU - Hughes, Michael E.. AU - Bortnick, Rachel. AU - Tsubouchi, Asako. AU - Bäumer, Philipp. AU - Kondo, Masahiro. AU - Uemura, Tadashi. AU - Schmucker, Dietmar. PY - 2007/5/3. Y1 - 2007/5/3. N2 - Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic binding. We report that Dscam controls cell-intrinsic aspects of dendrite guidance in all four classes of dendrite arborization (da) neurons. Loss of Dscam in single neurons causes a strong increase in self-crossing. Restriction of dendritic fields of neighboring class III neurons appeared intact in mutant neurons, suggesting that dendritic self-avoidance, but not heteroneuronal tiling, may depend on Dscam. Overexpression of the same Dscam isoforms in two da neurons with overlapping dendritic fields forced a spatial segregation of the two fields, supporting the ...
This function makes a list with oblique branches in addition to // the primary list in apical-tip-list.hoc // written by Yiota Poirazi, July 2001, [email protected] objref apical_tip_list_addendum apical_tip_list_addendum=new SectionList() // SISTER of apical_dendrite[3] is apical_dendrite[2] // SISTER of apical_dendrite[34] is apical_dendrite[33] // SISTER of apical_dendrite[37] is apical_dendrite[36] // SISTER of apical_dendrite[40] is apical_dendrite[39] // SISTER of apical_dendrite[45] is apical_dendrite[44] // SISTER of apical_dendrite[54] is apical_dendrite[53] // SISTER of apical_dendrite[68] is apical_dendrite[67] // SISTER of apical_dendrite[111] is apical_dendrite[110] // SISTER of apical_dendrite[115] is apical_dendrite[114] // SISTER of apical_dendrite[118] is apical_dendrite[117] apical_dendrite[2] apical_tip_list_addendum.append() // 1 degree 69.9821 microns from soma apical_dendrite[33] apical_tip_list_addendum.append() // 2 degrees 177.4831 (vertical distance) ...
Dendrites (from Greek δένδρον déndron, "tree")(also dendron) are the branched projections of a neuron that act to propagate the electrochemical stimulation received from other neural cells to the cell body, or soma, of the neuron from which the dendrites project. Electrical stimulation is transmitted onto dendrites by upstream neurons (usually their axons) via synapses which are located at various points throughout the dendritic tree. Dendrites play a critical role in integrating these synaptic inputs and in determining the extent to which action potentials are produced by the neuron.[1] Long outgrowths on immune system dendritic cells are also called dendrites. These are not to be confused with dendrites on a neuron. Dendritic cells are antigen-presenting cells in the mammalian immune system.[2] Their dendrites do not process electrical signals. Dendrites are one of two types of protoplasmic protrusions that extrude from the cell body of a neuron, the other type being an axon. Axons can ...
APP and its catabolite, Aβ, play critical roles in the etiology of AD (Selkoe and Schenk, 2003). In addition to neuronal death, numerous changes in dendritic architecture have been observed, including decrease of dendrite length and branching and loss of spines in transgenic mice overexpressing APP and in brains of persons dying of AD (Einstein et al., 1994; Masliah et al., 2001). The dendritic atrophy correlates well with the decrease of neurotrophins, such as BDNF (Hu and Russek, 2008; Zuccato and Cattaneo, 2009). In the present study, we found a regulatory role of LLLT for neuroprotection and dendritic morphogenesis. We demonstrated the ability of LLLT to rescue Aβ-induced dendritic atrophy and neuronal death. In Aβ-treated neurons, LLLT attenuated the decrease of both BDNF mRNA and protein levels and p-CREB, a transcriptional regulator of BDNF. Additionally, dendrite growth was improved after LLLT treatment, characterized by upregulation of PSD-95 expression, Rac1 activity, and the ...
Although hippocampal neurons are well-distinguished by the morphological characteristics of their dendrites and their structural plasticity, the mechanisms involved in regulating their neurite initiation, dendrite growth, network formation and remodeling are still largely unknown, in part because the key molecules involved remain elusive. Identifying new dendrite-active cues could uncover unknown molecular mechanisms that would add significant understanding to the field and possibly lead to the development of novel neuroprotective therapy since these neurons are impaired in many neuropsychiatric disorders. In our previous studies, we deleted the gene coding CRMP3 in mice and identified the protein as a new endogenous signaling molecule that shapes diverse features of the hippocampal pyramidal dendrites without affecting axon morphology. We also found that CRMP3 protects dendrites against dystrophy induced by prion peptide PrP106-126. Here, we report that CRMP3 has a profound influence on neurite ...
The hyperpolarization-activated cation current (Ih) plays an important role in regulating neuronal excitability, yet its native single-channel properties in the brain are essentially unknown. Here we use variance-mean analysis to study the properties of single Ih channels in the apical dendrites of cortical layer 5 pyramidal neurons in vitro. ... In contrast to the uniformly distributed single-channel conductance, Ih channel number increases exponentially with distance, reaching densities as high as approximately 550 channels/microm2 at distal dendritic sites. These high channel densities generate significant membrane voltage noise. By incorporating a stochastic model of Ih single-channel gating into a morphologically realistic model of a layer 5 neuron, we show that this channel noise is higher in distal dendritic compartments and increased threefold with a 10-fold increased single-channel conductance (6.8 pS) but constant Ih current density. ... These data suggest that, in the face of high ...
Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse motor cortex (M1), the main excitatory pathway controlling voluntary movement. In Jnk1-/- mice, basal dendrite branching of L5 pyramidal neurons is increased in M1, as is cell soma size, whereas in L2/3, dendritic arborization is decreased. We show that JNK1 phosphorylates rat HMW-MAP2 on T1619, T1622 and T1625 (Uniprot P15146) corresponding to mouse T1617, T1620, T1623, to create a binding motif, that is critical for MAP2 interaction with and stabilization of microtubules, and dendrite growth control. Targeted expression in M1 of GFP-HMW-MAP2 that is pseudo-phosphorylated on T1619, T1622 and T1625 increases
Pruning, referred to as selective removal of unnecessary neurites without cell death, occurs in both vertebrates and invertebrates. The Drosophila dorsal class IV dendritic arborization neuron (ddaC) can serve as an excellent model to study the mechanisms of dendrite pruning. To identify novel molecules orchestrating this developmental degeneration process, I performed an RNAi screen, from which a previously uncharacterized gene named pruning defect 1(prd1) was isolated. It binds to Adaptor Protein (AP)-2 complex and regulates dendrite pruning in a cell-autonomous manner. Consistently, AP-2 complex dependent endocytic degradation pathway is also important for dendrite pruning. Interestingly, Prd1 also complexes with a Kinesin-3 family member Immaculate connections (Imac), which plays a critical role in regulating dendrite pruning as well. With the help of Prd1, Imac transports AP-2 enriched Clathrin Coated Vesicles (CCVs) or endocytic vesicles from plasma membrane to early endosomes along ...
Although the concept of positional information was first applied to embryonic development (Wolpert, 1969), intracellular positional information governs morphogenesis of individual cells as well. For example, positioning the nucleus at the cell center and growth zones at the cell periphery depends on positional information from the microtubule cytoskeleton in Schizosaccharomyces pombe (Bähler and Pringle, 1998; Castagnetti et al., 2007; Hagan and Yanagida, 1997). Several lines of evidence support the existence of distinct subcompartments in axons and dendrites, but the forms of intracellular positional information and the coordinate systems that guide the development of these subcompartments have not been extensively characterized. Results from our screen and other studies suggest that at least two types of positional information govern C4da dendrite patterning. First, terminal branch distribution along the proximal-distal axis depends on microtubule-based processes; perturbing microtubule-based ...
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Although inhibitory inputs were also shown to terminate on the somata of SBC, the poorly understood eponymous bushy dendrite of SBC could play a key role in modulation. Anatomical studies of other labs revealed unexplained complexity: additional auditory nerve synapses, inhibitory synapses of various identities and sources and even non-auditory excitatory inputs are all found on the dendrites. Additionally, anatomical indications of electrical coupling of SBC dendrites were found. Physiological knowledge about all these findings is scarce or non-existent. It is therefore one of the main goals of the Künzel-lab to analyze the SBCs dendritic inputs and better understand their role in SBC signal processing. The main feature of SBC now becomes an experimental advantage: their responses are precisely phase-locked and their output eventually has to suffice for the coding interaural phase differences. Thus we possess an experimentally well-defined functional read-out that will likely reveal even ...
Dendrite formation is one of the most pressing issues in current battery research. Lithium based batteries are prone to forming short-circuit causing dendrites, while magnesium based batteries are not. Recently it was proposed that the tendency towards dendrite growth is related to the height of the self-dif 2018 Energy and Environmental Science HOT Articles
Antibodies and reagents. Mouse anti-MAP2 (AP20; specific for high-molecular-weight MAP2) and mouse anti-β-tubulin (KMX-1) were obtained from Leinco Technologies (St. Louis, MO). Mouse anti-JNK1 (G151-333) was obtained from PharMingen (San Diego, CA), and mouse anti-striatin was obtained from Transduction Laboratories (Lexington, KY). Rabbit anti-P-JNK, mouse anti-P-ERK, and mouse anti-ERK1/2 were obtained from Cell Signaling Technology (Beverly, MA), and anti-phosphorylated threonine flanked by proline (phospho-TP) was a gift from M. Melnick (Cell Signaling Technology). Mouse anti-actin was a gift from B. Jockusch (Technical University of Braunschweig, Braunschweig, Germany). Polyclonal anti-stress-activated protein kinase (SAPK) and anti-dephospho-MAP2 (972) were gifts from J. Kyriakis (Massachusetts General Hospital, Boston, MA) and J. Avila (Universidad Autónoma de Madrid, Madrid, Spain). Purified bovine high-molecular weight (HMW)-MAP2 was obtained from Cytoskeleton (Denver, ...
Protein synthesis in neuronal dendrites underlies long-term memory formation in the brain. Local translation of reporter mRNAs has demonstrated translation in dendrites at focal points called translational hotspots. Various reports have shown that hundreds to thousands of mRNAs are localized to dendrites, yet the dynamics of translation of multiple dendritic mRNAs has remained elusive. Here, we show that the protein translational activities of two dendritically localized mRNAs are spatiotemporally complex but constrained by the translational hotspots in which they are colocalized. Cotransfection of glutamate receptor 2 (GluR2) and GluR4 mRNAs (engineered to encode different fluorescent proteins) into rat hippocampal neurons demonstrates a heterogeneous distribution of translational hotspots for the two mRNAs along dendrites. Stimulation with s-3,5-dihydroxy-phenylglycine modifies the translational dynamics of both of these RNAs in a complex saturable manner. These results suggest that the ...
Huang W., She L., Chang X.Y., Yang R.R., Wang L., Ji H.B., Jiao J.W., Poo M.M.. Adult-born granule cells in the dentate gyrus of the rodent hippocampus are important for memory formation and mood regulation, but the cellular mechanism underlying their polarized development, a process critical for their incorporation into functional circuits, remains unknown. We found that deletion of the serine-threonine protein kinase LKB1 or overexpression of dominant-negative LKB1 reduced the polarized initiation of the primary dendrite from the soma and disrupted its oriented growth toward the molecular layer. This abnormality correlated with the dispersion of Golgi apparatus that normally accumulated at the base and within the initial segment of the primary dendrite, and was mimicked by disrupting Golgi organization via altering the expression of Golgi structural proteins GM130 or GRASP65. Thus, besides its known function in axon formation in embryonic pyramidal neurons, LKB1 plays an additional role in ...
We study the influences of thin and general diameter passive dendrites on the dynamics of single neuronal oscillators. For sufficiently thin dendrites and general somatic dynamics, we elucidate the mechanisms by which dendrites modulate the firing frequency of neurons. We find that the average value of the somatic oscillators phase response curve indicates whether or not the dendrite will cause an increase or decrease in firing frequency. For general diameter dendrites and idealized somatic dynamics, we find that the neuron displays bistable behavior between periodic firing and quiescence. In this case, the dendritic properties cause the cell to behave like a neuronal switch. Furthermore, we identify the mechanism that causes this bistability to occur. This mechanism was previously only described in models that contain active dendritic conductances ...
We report the electrodeposition of novel zinc dendrites composed of self-assembled regular hexagonal zinc nanodisks shelled with ZnO layers. The Zn nanodisks range in diameter from about 100 nm to several hundreds of nanometers and are about 20-40 nm thick. The thickness of ZnO layer is about 3-4 nm. In the as-prepared condition, the photoluminescence (PL) spectra of the dendrites are composed of a violet emission band at about 415 nm and a green emission band at about 550 nm at room temperature. The violet and green emissions are attributed to the radiative recombination of a delocalized electron close to the conduction band with a deeply trapped hole in the V Zn - and V O + centers, respectively. The PL of the dendrites can be tuned by heat treatment. With an increase in the heating temperature, the intensity of the green emission increases, while the intensity of the violet emission decreases ...
The formation of dendritic arbors is necessary for the proper establishment of neuronal circuits. The Drosophila transcription factor Spineless has been shown to play an important role in the control of dendritic morphogenesis, although the pathways through which it functions are not completely understood. Here, we show genetic evidence that Spineless interacts with the actin/microtubule cross linking protein Shortstop to control the dendrite arbor development of the dendritic arborization (da) sensory neurons. In addition, we have discovered a novel function for spineless as we show that spineless mutant larvae exhibit an increased sensitivity to specific odorants in the absence of morphological defects of the chemosensory organs. These data show that spineless acts in multiple cell-specific contexts to control the diversification of sensory neuron morphology and function.
Scanning electron micrograph of dendrite. From the Greek dendron or tree, dendrites are bush like projections sprouting from a nerves center, or cell body. Dendrites bring information from outside sources such as other neurons or sensory cells to the neurons cell body. As the dendrites transmit information towards the cell body, a longer projection called the axon will carry information away from the cell body to other neurons. - Stock Image C001/5259
Many central nervous system (CNS) neurons have extensively pocampal pyramidal neurons, markedly reducing AP firing arborized dendrites on which they receive the majority of their when initiated from dendritic depolarization, but minimally synaptic contacts. Recent advances in electrophysiological tech- affecting APs initiated from somatic depolarization. This effect niques have shown that the apical dendrites of hippocampal on dendritic excitability was not due to action on Na+ chan- and neocortical pyramidal neurons have markedly different nels, but rather to an increase in Ih, a voltage-gated current electrical properties from those of their corresponding soma- present in high density in the dendrites. These results show ta, and these differing properties are due to non-uniform dis- that a drug can affect excitability and AP firing regionally with- tributions and kinetics of voltage-gated channels. For example, in a neuron, and provide evidence that Ih is centrally involved in hippocampal ...
Intracellular mRNA transport and local translation play a key role in neuronal physiology. Translationally repressed mRNAs are transported as a part of ribonucleoprotein (RNP) particles to distant dendritic sites, but the properties of different RNP particles and mechanisms of their repression and transport remain largely unknown. Here, we describe a new class of RNP-particles, the dendritic P-body-like structures (dlPbodies), which are present in the soma and dendrites of mammalian neurons and have both similarities and differences to P-bodies of non-neuronal cells. These structures stain positively for a number of P-body and microRNP components, a microRNA-repressed mRNA and some translational repressors. They appear more heterogeneous than P-bodies of HeLa cells, and they rarely contain the exonuclease Xrn1 but are positive for rRNA. These particles show motorized movements along dendrites and relocalize to distant sites in response to synaptic activation. Furthermore, Dcp1a is stably ...
Kv4.2 is abundant in the dendrites of CA1 pyramidal neurons of the hippocampus.[293]. Kv4.2 and Kv4.3 are expressed in membranes of somata, dendrites, and spines of pyramidal cells and GABAergic neurons. [319]. KChIP2 co-localizes with Kv4.2 in the dendrites of granule cells in the dentate gyrus (Fig. 3d-f), in the apical and basal dendrites of hippocampal and neocortical pyramidal cells, and in several subcortical structures including the striatum and thalamus [1195]. Immunocytochemical studies have shown that the subcellular distribution of neuronal rat Kv4.2 channels is restricted to the somatodendritic area, and the high abundance of Kv4.2 in the soma and dendrites led to the hypothesis that these channels may have an important influence on postsynaptic neuronal signal transduction [1686]. Immunohistochemical analysis shows that Kv4.2 has a somatodendritic distribution, and in adult hippocampus, Kv4.2 is expressed on distal dendrites and neuropils of CA1-3 neurons. The somatodendritic ...
Each neuron has a hair-like structure surrounding it - these are the dendrites. Dendrites are some tens of microns in length. The branch out into a tree-like form around the cell body. The dendrites are like electrical cables which serve to conduct incoming signals to the cell. The axon or nerve fiber is the outgoing connection for signals emitted by the neuron. It differs from the dendrites in its shape and by the properties of its external membrane. It is usually much longer than the dendrites, varying from a millimeter (one thousandth of a meter) to one meter. At its end it branches into smaller structures which communicate with other neurons. The branching of the dendrites, in contrast, takes place much closer to the cell body. Neurons are connected together at these extremities in a complex spatial arrangement. Typically a given neuron is connected to about ten thousand other neurons. The specific point of contact between the axon of one cell and a dendrite of another is called a synapse. ...
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the establishment of the neuromuscular junction. Here, we show that LRP4 is also expressed by embryonic cortical and hippocampal neurons, and that downregulation of LRP4 in these neurons causes a reduction in density of synapses and number of primary dendrites. Accordingly, overexpression of LRP4 in cultured neurons had the opposite effect inducing more but shorter primary dendrites with an increased number of spines. Transsynaptic tracing mediated by rabies virus revealed a reduced number of neurons presynaptic to the cortical neurons in which LRP4 was knocked down. Moreover, neuron-specific knockdown of LRP4 by in utero electroporation of LRP4 miRNA in vivo also resulted in neurons with fewer primary dendrites and a lower density of spines in the developing cortex and hippocampus. Collectively, our results demonstrate an essential and novel role of neuronal LRP4 in dendritic development and ...
Down regulation of GGTβ decreases dendrite growth and branching of PCs. A) HEK293 cells were co-transfected with Myc-GGTα and HA-GGTβ, together with pSUPER-G
July 14th, 2017 , by April Gocha. New research from MIT shows that firmness isnt the most important parameter for developing a solid electrolyte that is effective against dendrite formation-instead, a defect-free surface, which doesnt provide a place for dendrites to form, is key to a better battery. ...
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Researchers have proposed that a malfunction during brain development when neurons are growing and forming connections with other nerve cells is an underlying cause of autism. In particular, there appears to be impairments in the growth of dendrites-branch-like protrusions the neurons use to form connections with other nerve cells.
The apical dendrites of cortical pyramidal cells are aligned ,perpendicular to the cortical surface -- this allows the PSPs in ,the apical dendrites of many (millions?) cortical pyramidal ,cells to summate spatially, and thus be detectable on the ,cortical or scalp surface. The dendrites of other cell types ,are generally aligned in random directions, so that the PSPs in ,these dendrites cancel each other (when observed from an ,electrode that is far away). ,clip, ,Kevin Kevin, thanks for replying to my post and to the one above. Since the brain has many folds & invaginations, many of the apical dendrites would not be at right angles to the surface of the brain. Why isnt this a problem in assuming the valididty of EEG recordings ? Would local field potentials recorded from one laminellar layer be a more suitable means for determining the activity of a brain area and perhaps for investigating the relationship between say, midbrain structures and the cortex ? Thanks for your attention. Mark ...
TY - JOUR. T1 - A pair of descending neurons with dendrites in the optic lobes projecting directly to thoracic ganglia of dipterous insects. AU - Nässei, D. R.. AU - Strausfeld, Nicholas J. PY - 1982/9. Y1 - 1982/9. N2 - The lobula descending neuron (LDN) of dipterous insects is a unique nerve cell (one on each side of the brain) that projects directly from the lobula complex of the optic lobes to neuropil in thoracic ganglia. In the supraoesophageal ganglia the LDN has two prominent groups of branches of which at least one is dendritic in nature. Postsynaptic branches are distributed in the lobula and some branches, the synaptic relations of which are not yet known, extend to the lobula plate. A second group of branches is found among dendrites of the descending neurons proper, in the lateral midbrain. The arborizations of LDN in the lobula (and lobula plate) map onto a retinotopic neuropil region subserving a posterior strip of the visual field of the compound eye. The arborizations in the ...
Figure 1. Schematic illustration of the signaling pathway of mitochondria-mediated dendritic loss. Mitochondria are impaired in dendritic terminals under stress conditions. Mitochondrial malfunction induces eIF2α phosphorylation that subsequently results into protein translational inhibition in the dendrites of class IV neurons. As a result, the activation of glycolysis is enhanced, which alters growth and stability of class IV dendritic arbors, leading to dendritic loss. ...
Purpose: Chronic cerebral ischemia is a common pathological state, which can lead to cognitive disorder and neurological dysfunction. Aminoguanidine i..
Cracked Dendrite font is a fancy, eroded font designed by Spork Thug Typography. Cracked Dendrite font is free for both personel and commercial usages.
Effect of VGCC blockers on uncaging-evoked Ca2+ responses in an FS-PV IN. A) Maximum intensity z projection image of a distal dendritic segment. Average uncaging-evoked Ca2+ responses in control conditions (middle) and in the presence of a cocktail of VGCC blockers (bottom). White points are active input locations used for DNI-Glu,TFA uncaging (top). B) Spatial distribution of the peak dendritic Ca2+ response measured along the white line in (A) under control conditions (black) and in the presence of VGCC blockers (red). Inset: mean Ca2+ transients derived from the hot spot (green) and lateral dendritic (magenta) regions before (solid line) and after (dashed line) application of the VGCC cocktail. ...
How has such a wealth of computational power previously escaped scientists watchful eyes?. Part of it is mainstream neuroscience theory. According to standard teachings, dendrites are passive cables that shuttle electrical signals to the neuronal body, where all the computation occurs. If the integrated signals reach a certain threshold, the cell body generates a sharp electrical current-a spike-that can be measured by sophisticated electronics and amplifiers. These cell body spikes are believed to be the basis of our cognitive abilities, so of course, neuroscientists have turned their focus to deciphering their meanings.. But recent studies in brain slices suggest that the storys more complicated. When recording from dendrites on neurons in a dish, scientists noticed telltale signs that they may also generate spikes, independent of the cell body. Its like suddenly discovering that cables leading to your computers CPU can also process information-utterly bizarre, and somewhat ...
Lets consider the picture. The large yellow and green sphere is a brain cell called a neuron. From it you see branches stretching out called dendrites. Signals pass between neurons by electrochemicals that pass between the dendrites at junctions called synapses. So what are the small bright spots? They are the synapses that excite as electrochemical signals pass between the dendrites. What Drs. Arnold and Roberts observe is the change of those spots that indicate how "synaptic structures in the brain have been altered by the new data," according to author Robert Perkins ...
The 2018 Gordon Research Conference on Dendrites: Molecules, Structure and Function will be held in Lucca (Barga), Italy. Apply today to reserve your spot.
The 2018 Gordon Research Seminar on Dendrites: Molecules, Structure and Function (GRS) will be held in Lucca (Barga), Italy. Apply today to reserve your spot.
Not all proteins that accumulate in a specific subcellular compartment undergo processes of selective sorting and transport. Some proteins seem to be localized by a mechanism known as selective retention, which describes that cargoes are transported nonselectively to both axons and dendrites, but are eliminated at one side by selective endocytosis and retained at the other, where endocytosis is prevented. Prominent examples for this process are the proteins VAMP2 and NgCAM. NgCAM is sorted into carriers that preferentially deliver their cargo proteins to the axonal membrane. In contrast, VAMP2 is delivered to the surface of both axons and dendrites; however it is preferentially endocytosed from the dendritic membrane, a process, which also results in an axonal enrichment31. Indeed, VAMP2 harbors an endocytosis signal in its cytoplasmic domain, and mutation of this sequence consistently results in an evenly distribution of VAMP2 to cell body, dendrites, and axon. Although such process initially ...
van den Burg, E.H., Engelmann, J., Bacelo, J., Gómez, L., Grant, K.: Etomidate reduces initiation of backpropagating dendritic action potentials: implications for sensory processing and synaptic plasticity during anesthesia. Journal of neurophysiology. 97, 2373-2384 (2007 ...
van den Burg, E. H., Engelmann, J., Bacelo, J., Gómez, L., & Grant, K. (2007). Etomidate reduces initiation of backpropagating dendritic action potentials: implications for sensory processing and synaptic plasticity during anesthesia. Journal of neurophysiology, 97(3), 2373-2384. doi:10.1152/jn. ...
Other Toh-IR dendrites in the tissue were studied but did not necessarily get traced to the Toh-IR cell body. In the 15 um thick slab of tissue studied by EM, the Toh-IR cell and related processes received mostly amacrine synapses (red) in all strata of the IPL, and a few bipolar ribbon synapses (green) to the main tiers of dendrites in stratum 1, strata 2/3 and 4/5 borders. Toh-IR stained profiles were presynaptic to amacrine and ganglion cell processes (blue, yellow). Postsynaptic ganglion cell dendrites costratified in the three main dendritic tiers of the Toh-IR cell.. ...
Fourteen detailed 3D somato-dendritic morphologies of cat spinal alpha-motoneuron imported from NeuroMorpho.org (Ascoli et al., 2007). The vertical upward neuri
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Dendrite refers to the Trees in Greek, so these are the branched small extension of the nerve cell.Axon refers to the axis in Greek, so axon is the long slender like protrusion of the neuron or nerve cell.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Vulnerable Dendrites and Synapses in Aging and Alzheimers Disease (R01) PA-09-061. NIA
Answers to the question, Has Anyone Had Their Dendrites Checked For Abnormalities. Answers to Questions from People Who Know at Ask Experience Project.
This week, were going back to our basic science roots and discussing dendrite repair in the fly brain. Also the dark side of genius and kids editing science.
Sigma-Aldrich offers abstracts and full-text articles by [Takahiro Kanamori, Makoto I Kanai, Yusuke Dairyo, Kei-ichiro Yasunaga, Rei K Morikawa, Kazuo Emoto].
Type-specific dendritic arborization patterns dictate synaptic connectivity and are fundamental determinants of neuronal function. We exploit the morpholog