The cholinesterase inhibitors reduce synaptic breakdown of the neurotransmitter acetylcholine, enhancing cholinergic transmission. They were originally developed in response to basic research showing a cholinergic deficit in patients with AD dementia. Subsequent work suggests that cerebrovascular injury also damages cholinergic pathways.20 Three cholinesterase inhibitors were tested in phase 3 trials of patients with vascular dementia or mixed dementia-donepezil,21, 22, 23 galantamine,24, 25 and rivastigmine26-and the results have been pooled and analyzed by the Cochrane collaboration.27, 28, 29 All of the phase 3 RCTs were 6 months in duration, and NINDS‐AIREN (National Institute of Neurological Disorders and Stroke and the Association Internationale pour la Recherche et lEnseignement en Neurosciences) criteria30 were used to diagnose vascular dementia. All trials used the Alzheimers Disease Assessment Scale‐Cognitive (ADAS‐Cog), or variants incorporating additional tests of executive ...
Background and Purpose: We sought to assess the efficacy and safety of donepezil in patients with vascular dementia (VaD) fulfilling National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et lEnseignement en Neurosciences criteria.; Methods: This international, multicenter, 24-week trial was conducted from March 2003 to August 2005. Patients (N=974; mean age, 73.0 years) with probable or possible VaD were randomized 2:1 to receive donepezil 5 mg/d or placebo. Coprimary outcome measures were scores on the Vascular-Alzheimer Disease Assessment Scale-Cognitive Subscale and Clinicians Interview-Based Impression of Change, plus carer interview. Analyses were performed for the intent-to-treat population with the last-observation-carried-forward method.; Results: Compared with placebo, donepezil-treated patients showed significant improvement from baseline to end point on the Vascular-Alzheimer Disease Assessment Scale-Cognitive Subscale (least-squares ...
All patients with stroke were classified into the following diagnostic groups: VaD, vascular mild cognitive impairment, aphasia, and strokes with normal cognition. VaD was diagnosed as fulfilling National Institute of Neurological Disorders and Stroke and Association Internationale pour la Recherche et lEnseignement en Neurosciences (NINDS-AIREN) criteria for possible or probable VaD.11 Vascular mild cognitive impairment was diagnosed in subjects with impairment in at least 1 cognitive domain subscore of ACE-R, that is, attention, memory, fluency, language, and visuospatial domains, and absence of dementia on clinical interview or Clinical Dementia Rating scale. Impairment in a cognitive domain was defined if the score on the ACE-R subdomain was ,2.00 SD below the mean level of age and education-matched norms. Patients with vascular mild cognitive impairment and VaD were considered to have poststroke cognitive impairment. Diagnosis of aphasia was made by 2 experienced behavioral neurologists ...
Cette série de livres du Centre de lOCDE pour la recherche et les innovations pédagogiques fournit les résultats des travaux de lOCDE sur
Aim: To compare serum level of matrix metalloproteinase 3 (MMP3) and tissue inhibitor metallo-proteinase 1 (TIMP1) in vascular dementia patients and healthy control subjects. Methods: A case control study was carried out in Ain Shams University hospital, Cairo, Egypt. 32 cases with vascular dementia were collected and classified into 2 subgroups; vascular dementia of multiinfarct type (VDMI) 14 patients, and vascular dementia of subcortical type (VDSC) 18 subjects. 23 cases with normal cognitive functions were collected as control group. Cases were subjected to comprehensive geriatric assessment, neurological examination, neuropsychological testing and brain CT scan. Blood sample was collected to analyze serum level of matrix metalloproteinase 3 (MMP3) and tissue inhibitor metalloproteinase 1 (TIMP1). Results: Mean serum level of TIMP1 (20.85 × 103 picogram/ml) was significantly lower than mean serum level of TIMP1 in control group (27.69 × 103 picogram/ml) (p = 0.018). The same finding was also
Research has shown that mixed dementia is more common than previously believed but little is known of its early stages.To examine if incipient mixed dementia can be differentiated from incipient Alzheimers disease (AD) and subcortical ischemic vascular dementia (SVD) using neuropsychological tests, cerebrospinal fluid (CSF) markers, and magnetic resonance imaging markers.We included 493 patients and controls from the Gothenburg MCI study and used the dementia groups for marker selection (CSF total-tau (T-tau), phospho-tau (P-tau), and amyloid-β42 (Aβ42), 11 neuropsychological tests, and 92 regional brain volumes) and to obtain cut-off values which were then applied to the MCI groups.Incipient mixed dementia was best differentiated from incipient AD by the Word fluency F-A-S test and the Trail making test A. CSF T-tau, P-tau, and Aβ42 differentiated incipient mixed dementia from incipient SVD.Incipient mixed dementia is characterized by an AD-like biomarker profile and an SVD-like cognitive ...
White matter hyperintensities also occurred often in all groups and differences between demented and non-demented patients largely resulted from variations in the severity and distribution of lesions. The pattern of WMHs in dementia with Lewy bodies was broadly similar to Alzheimers disease, but less extensive than vascular dementia. The prevalence of WMHs in vascular dementia and Alzheimers disease conformed well with previous studies, which have detected WMHs in up to 100% of patients with vascular dementia7 12 and between 60%-100% of patients with Alzheimers disease.2 The pathological correlates of WMHs in dementia with Lewy bodies have not yet been determined. The similar pattern of hyperintensities in dementia with Lewy bodies and Alzheimers disease suggests that they may share a convergence in white matter pathology. White matter lesions in Alzheimers disease have been linked to ischaemic changes46 but histological findings from other studies have identified various abnormalities, ...
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Publications. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimers disease. Nat Genet. 2017 Sep; 49(9):1373-1384. View in: PubMed. Patient and caregiver reactions to clinical amyloid imaging. Alzheimers Dement. 2017 Aug; 13(8):924-932. View in: PubMed. A novel PSEN1 (S230N) mutation causing early-onset Alzheimers Disease associated with prosopagnosia, hoarding, and Parkinsonism. Neurosci Lett. 2017 Jul 29; 657:11-15. View in: PubMed. Presymptomatic atrophy in autosomal dominant Alzheimers disease: A serial MRI study. Alzheimers Dement. 2017 Jul 22. View in: PubMed. A comparison of theoretical and statistically derived indices for predicting cognitive decline. Alzheimers Dement (Amst). 2017; 6:171-181. View in: PubMed. Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort. Dement Geriatr Cogn Disord. 2017; 44(1-2):1-11. View in: PubMed. Two Novel Mutations in the ...
MRI showed white matter changes in all 29 patients with vascular dementia and in eight out of 22 patients with Alzheimers disease. The corresponding figures for CT were 26 and 1, respectively. White matter changes are therefore a useful diagnostic aid in the differential diagnosis between vascular dementia and Alzheimers disease.. ...
Vascular dementia is often diagnosed after a stroke. Learn the vascular dementia symptoms and risk factors to ensure your loved one can receive proper care.
If you are worried about vascular dementia, this guide is for you. It provides information about the signs of vascular dementia, living with the condition, and getting help and support.
Binswangers disease, also known as subcortical leukoencephalopathy, is a form of small vessel vascular dementia caused by damage to the white brain matter. White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. This disease is characterized by loss of memory and intellectual function and by changes in mood. These changes encompass what are known as executive functions of the brain. It usually presents between 54 and 66 years of age, and the first symptoms are usually mental deterioration or stroke. It was described by Otto Binswanger in 1894, and Alois Alzheimer first used the phrase "Binswangers disease" in 1902. However, Olszewski is credited with much of the modern-day investigation of this disease which began in 1962. Symptoms include mental deterioration, language disorder, transient ischemic attack, muscle ataxia, and impaired movements including change of walk, slowness of movements, and change in posture. These symptoms usually ...
Hillary Clinton might actually have 1 year to live based on medical records that were leaked indicating she has a disease called Subcortical Vascular Dementia. While many videos have been made about her health, all of them have missed the severity of her illness. She could die very soon, since Vascular Dementia is progressive and has a 3-5 year life expectancy. Clinton actually has a severe form of the disease that impacts the subcortex region of the brain, which includes the brainstem. This might explain why Clinton is dry-coughing so much. The brainstem controls primitive functions of the body like breathing, heart rate, and blood pressure. When there is ischemia to this region, B/P, HR, and breathing wont function correctly. Hillarys cough is so noticeable because she cant seem to get over it. Most people only need a couple of coughs and they are able to overcome what is in their throat. But not Hillary. Hillary has tried to explain that she has an "allergic cough." This is completely ...
METHODS: Proton density and T2 weighted images were obtained on a 1.0 Tesla MRI scanner in patients with dementia with Lewy bodies (consensus criteria; n=27, mean age=75.9 years), Alzheimers disease (NINCDS/ADRDA; n=28, mean age=77.4 years), vascular dementia (NINDS/AIREN; n=25, mean age=76.8 years), and normal controls (n=26, mean age=76.2 years). Cognitive function, depressive symptoms, and psychotic features were assessed using a standardised protocol. Periventricular hyperintensities (PVHs), white matter hyperintensities (WMHs) and basal ganglia hyperintensities (BGHs) were visually rated blind to diagnosis using a semiquantitative scale ...
Binswangers disease. Coloured axial computed tomography (CT) scan of a brain with Binswangers disease. The front of the brain is at top in this view from below. The progression of this degenerative disease has caused atrophy in both halves of the brain, seen as the abnormal gaps appearing in the brain tissue. The ventricles (centre, orange) have also been affected and are dilated from their normal size. The disease, also called Binswangers dementia, involves disruption of the brains blood supply, which starves areas of the brain of oxygen, resulting in the death of nerve cells. Symptoms include depression, muscle rigidity, difficulties walking and urinary incontinence. There is no cure for the condition. - Stock Image C001/7913
(title:mixed dementia AND body:mixed dementia) OR title:mixed dementia, prevent mixed dementia, impact of mixed dementia, symptoms of mixed dementia
(title:mixed dementia AND body:mixed dementia) OR title:mixed dementia, prevent mixed dementia, impact of mixed dementia, symptoms of mixed dementia
Korean ADNI (K-ADNI) is working to comply with international standards of world-wide ADNI for development of new drugs for Alzheimers Disease dementia patients; to evaluate the effects of vascular risk factors on Alzheimers disease progression and Subcortical Vascular Dementia (SVaD), which comprises relatively large proportion of Asian dementia patients; and to establish the efficacy approval system for new dementia drugs. They are recruiting and collecting data comparable to that gathered through other WW-ADNI centers and data collected throughout this study are available to the research community. Recently, Korea ADNI was approved for government funding.. View more information about Korean ADNI. ...
Alzheimers disease (AD) is the most common form of dementia found in all human populations worldwide, while vascular dementia (VaD) is the second most common form of dementia. New biomarkers for early and specific diagnosis of AD and VaD are needed to achieve greater insight into changes occurring in the brain and direct therapeutic strategies. The objective of this explorative study was to discover candidate protein biomarkers for the differential diagnosis between VaD and AD. Surface-enhanced laser desorption/ionization (SELDI) TOF-MS was used to differentially profile proteins and peptides in CSF samples from 28 AD patients and 21 patients with VaD. A combination of univariate (Kruskal-Wallis) and multivariate (independent component analysis) statistical approaches produced a list of 27 proteins and peptides that could differentiate between VaD and AD. These markers represent various physiological processes, such as protein degradation (ubiquitin), protease inhibition (cystatin C and alpha-1
The clinical diagnosis of vascular dementia (VaD) is based on imaging criteria, and specific biochemical markers are not available. Here, we investigated the potential of cerebrospinal fluid (CSF) lipocalin 2 (LCN2), a secreted glycoprotein that has been suggested as mediating neuronal damage in vascular brain injuries. The study included four independent cohorts with a total n = 472 samples. LCN2 was significantly elevated in VaD compared to controls, Alzheimers disease (AD), other neurodegenerative dementias, and cognitively unimpaired patients with cerebrovascular disease. LCN2 discriminated VaD from AD without coexisting VaD with high accuracy. The main findings were consistent over all cohorts. Neuropathology disclosed a high percentage of macrophages linked to subacute infarcts, reactive astrocytes, and damaged blood vessels in multi-infarct dementia when compared to AD. We conclude that CSF LCN2 is a promising candidate biochemical marker in the differential diagnosis of VaD and ...
Stroke and dementia are the two leading causes of neurological disability in the UK and are the most costly in terms of health and social care. Stroke and dementia share risk factors and often co-exist, each increasing the risk and severity of the other. The aim of our theme is to improve the prevention of diseases of the blood vessels which can lead to stroke and vascular dementia and identify better ways to treat them.. We use a variety of strategies and methodology for our research projects, including population-based cohort studies, state of the art brain and blood vessel imaging, biobanks and collaborative analyses of multiple randomised clinical trials. We also have a large collection of brains donated by people for research after their death, which are used to better understand the changes that occur with these conditions. Our projects aim to:. ...
Dementia is a gradual and permanent loss of brain function. This occurs with certain diseases. It affects memory, thinking, language, judgment, and behavior. Vascular dementia (VaD) is caused by a series of small strokes over a long period.
My mother who is 70, has been diagnosed with a Vascular Dementia Condition. This is further complicated by depression. She is on treatment for depression, asprin and a statin. I always thought Demen...
Mum is 92 and was diagnosed with vascular dementia 12 years ago. It has been a gentle, slow decline although getting noticeably worse over the past two...
Background: Physical exercise has several beneficial effects, including reduced risk for Alzheimers disease. Although several studies of potential risk factors for vascular dementia (VaD) exist, including physical activity, the studies have usually included few participants and there are no meta-analyses addressing this key topic. Methods: The MEDLINE database was searched using the key words physical exercise activity or walking in combination with dementia and vascular dementia. Potentially relevant studies were assessed and summarised by two of the authors, and longitudinal studies with operationalised definition of physical activity providing risk for VaD in both groups were included in the meta-analysis using pooled estimates from a random effects model. Results: A total of 24 longitudinal studies, including 1378 patients with VaD, were included in the review. The majority of individual studies did not report significant associations. Five studies fulfilled criteria for ...
Vascular dementia (VaD) is caused by the reduction of blood supply by vessel occlusion and is characterized by progressive cognitive decline. VaD incidence has been growing due to the aging population
DNAnexus, Inc., le chef en informatique biomédicale et gestion des données, a aujourdhui annoncé lajout dun navigateur novateur pour les cohortes clinico-génomiques à sa plate-forme de
Learn more about Vascular Dementia at Doctors Hospital of Augusta DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Learn more about Vascular Dementia at Memorial Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Information on these pages aims to give an introduction to vascular dementia. We hope you will find it helpful.. This information was updated in January 2016 and is due for review in January 2018. Please contact us if you would like a version with references.. ...
Delta DNA Inc. hopes to develop a kit to recover fetal DNA in maternal blood. By recovering fetal DNA, the fetus genetic issues, if any, can be detected more quickly and more reliably than with an invasive method such as amniocentesis. La Cité supported the business through the proof-of-concept phase of the project and contributed to recruiting pregnant women. The business developed a blood collection and conservation device that must be validated. The projects main challenge is to find ways to stabilize and efficiently recover the fetal DNA that is present in minuscule quantities in the mothers blood. ...
Fabula, actualités et ressources pour la recherche et les études littéraires : revue, annonces de colloques et dappels à contribution, parutions, comptes rendus critiques et débats
Fabula, actualités et ressources pour la recherche et les études littéraires : revue, annonces de colloques et dappels à contribution, parutions, comptes rendus critiques et débats
ILMAC: Salon pour la recherche et développement, technologie environnementale, technique des procédés dans la pharmacie, la chimie et la biotechnologie.
This years Princeton conference featured a session on vascular cognitive impairment (VCI), signaling recognition, a long time in coming, of this important consequence of cerebrovascular disease. The emphasis was on cerebrovascular dysregulation and small vessel white matter disease, drawing from animal models, human pathology, neuroimaging, epidemiology, and the recent clinical trial in CADASIL, as summarized below.. Cerebrovascular oxidative stress from reactive oxygen species mediated by NADPH oxidase present in cerebral vessels may be the final common pathway of the cerebrovascular dysregulation induced by aging, Alzheimer disease (AD), and hypertension, according to Iadecola and colleagues.1 Cerebral energy demands are serviced through control mechanisms such as functional hyperemia and cerebrovascular autoregulation, which tailor the blood supply to tissue needs and maintain perfusion over a wide range of blood pressures. Aging changes the structure and vasodilatory capacity of vessels, ...
MacKnight C, Rockwood K, Awalt E, McDowell I. Diabetes mellitus and the Risk of Dementia, Alzheimers Disease and Vascular Cognitive Impairment in the Canadian Study of Health and Aging. Dement Geriatr Cogn Disord. 2002; 14(2): 77-83 ...
Vascular Cognitive Impairment Stroke Strategies SLP Network September 25, 2010 Angela South University of Western Ontario Health and Rehabilitation Sciences Disclosures Funding from Parkinsons Society Canada CIHR, NSERC, Parkinsons Society Canada and Alzheimers Society funded laboratories A man does not consist of memory alone. He has feeling, will, sensibilities, moral being --- matters of which neuropsychology cannot speak. And it is here, beyond the realm of an impersonal psychology, that you may find ways to touch him, and change him. Luria AR From a personal letter to Oliver Sacks quoted in his 1985 book The Man Who Mistook His Wife For a Hat London: Picador (p.32) Objectives  Review the incidence and prevalence of dementia and vascular cognitive impairment  Define vascular cognitive impairment and subtypes  Define the risk factors for vascular cognitive impairment  Discuss the impact of post-stroke cognitive impairment  Review a historical perspective of VCI  Discuss ...
Loption médecine cellulaire et moléculaire à lIRCM offre une formation en recherche translationnelle, soit larrimage de la recherche fondamentale en laboratoire aux besoins de la pratique en clinique.
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The study found the top one-third of participants who exerted the most energy walking were 27 percent less likely to develop vascular dementia than those people in the bottom one-third of the group. Participants who scored in the top one-third for the most energy exerted in moderate activities lowered their risk of vascular dementia by 29 percent and people who scored in the top one-third for total physical activity lowered their risk by 24 percent compared to those in the bottom one-third.. "Our findings show moderate physical activity, such as walking, and all physical activities combined lowered the risk of vascular dementia in the elderly independent of several sociodemographic, genetic and medical factors," said study author Giovanni Ravaglia, MD, with University Hospital S. Orsola Malpighi, in Bologna, Italy. "Its important to note that an easy-to-perform moderate activity like walking provided the same cognitive benefits as other, more demanding activities.". Ravaglia says its possible ...
By developing native and glycosylated forms of the angiotensin-(1-7) peptide for vascular cognitive impairment, ProNeurogen hopes to plug a treatment gap that repurposed Alzheimers disease drugs have failed to fill.
Contents: Preface; Part I. Vascular Cognitive Impairment: 1. Introduction: what is vascular cognitive impairment? José G. Merino and Vladimir Hachinski; 2. Vascular cognitive impairment in the memory clinic Paige Moorhouse and Kenneth Rockwood; 3. Vascular cognitive impairment in the stroke unit and after the acute stage Olivier Godefroy, Claire Leclercq and Martine Roussel; Part II. Analytic Approach: The Behavioral and Cognitive Neurology of Stroke: 4. Cognitive and behavioral disorders according to stroke site and side Isabel P. Martins, Lara Caeiro and José M. Ferro; Section 1. Motor and Gestural Disorders: 5. Movement and gestural disorders: abnormal movement and motor behavior Luc Defebvre and Pierre Krystkowiak; 6. Limb apraxia: a disorder of gesturing and object use Tim Vanbellingen and Stephan Bohlhalter; Section 2. Aphasic, Arthric, Calculation, and Auditory Disorders: 7. Vascular aphasias Alexandre Croquelois and Olivier Godefroy; 8. Dysarthria Pascal Auzou; 9. Alexia and agraphia ...
Various forms of cerebrovascular disorders may lead to cognitive impairment and dementia in the elderly [17]. While pure VaD - most frequently caused by infarctions - is rare, it is generally assumed that cerebrovascular pathology contributes to the development of cognitive impairment in other neurodegenerative diseases, in particular in mixed AD/VaD. Such mixed disorders are frequently observed in the brains of elderly individuals and their prevalence and severity increase with advancing age [37]. In aged individuals, lacunes, microbleeds, WMLs and microinfarcts have been associated with cognitive decline, including reduced mental speed and impaired executive functions [38]. Cerebral SVD may interact with pathophysiological processes in AD either independently of each other or through additive or synergistic effects on cognitive decline [39, 40]. There are several clinical classification criteria for VaD/VCI, such as the NINDS-AIREN criteria, the State of California Disease Diagnostic and ...
ANDRADE, Silviane Pinheiro Campos de; BRUCKI, Sônia Maria Dozzi; BUENO, Orlando Francisco Amodeo and SIQUEIRA NETO, José Ibiapina. Neuropsychological performance in patients with subcortical stroke. Arq. Neuro-Psiquiatr. [online]. 2012, vol.70, n.5, pp.341-347. Epub Feb 24, 2012. ISSN 0004-282X. http://dx.doi.org/10.1590/S0004-282X2012005000012.. Vascular cognitive impairment (VCI) is characterized by cognitive compromise predominantly of executive dysfunction. OBJECTIVES: To assess cognitive functions in VCI, focusing on executive functions, to observe functional losses in relation to activities of daily living (ADLs) and to detect early symptoms prior to the onset of dementia. METHODS: We evaluated healthy subjects matched for gender, education and age to patients with diagnosis of subcortical vascular disease who had a stroke classified into three groups: 1) vascular lesions and no impairment; 2) vascular cognitive impairment with no dementia (VCIND); 3) vascular dementia (VaD). RESULTS AND ...
médecine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, médicale et en santé
Results A total of 23 ACMIs were found in 16 of the 783 patients (2.0%). Patients with ACMIs did not differ in vascular risk or cognitive profile, but were more often diagnosed with vascular dementia (odds ratio [OR] 5.1; 95% confidence interval [CI] 1.4-18.9, p = 0.014). ACMI presence was associated with lower levels of β-amyloid (p , 0.004) and with vascular imaging markers (lacunar infarcts: OR 3.5, CI 1.3-9.6, p = 0.015; nonlacunar infarcts: OR 4.1, CI 1.4-12.5, p = 0.012; severe white matter hyperintensities: OR 4.8, CI 1.7-13.8, p = 0.004; microbleeds: OR 18.9, CI 2.5-144.0, p = 0.0001). After a median follow-up of 2.1 years, the risk of poor clinical outcome (composite of marked cognitive decline, major vascular event, death, and institutionalization) was increased among patients with ACMIs (hazard ratio 3.0; 1.4-6.0, p = 0.005). ...
Neuroimaging evidence from older stroke survivors in Nigeria and Northeast England showed medial temporal lobe atrophy (MTLA) to be independently associated with post-stroke cognitive impairment and dementia. Given the hypothesis ascribing MTLA to neurodegenerative processes, we assessed Alzheimer pathology in the hippocampal formation and entorhinal cortex of autopsied brains from of post-stroke demented and non-demented subjects in comparison with controls and other dementias. We quantified markers of amyloid β (total Aβ, Aβ-40, Aβ-42, and soluble Aβ) and hyperphosphorylated tau in the hippocampal formation and entorhinal cortex of 94 subjects consisting of normal controls (n = 12), vascular dementia, VaD (17), post-stroke demented, PSD (n = 15), and post-stroke non-demented, PSND (n = 23), Alzheimers disease, AD (n = 14), and mixed AD and vascular dementia, AD_VAD (n = 13) using immunohistochemical techniques ...
TY - JOUR. T1 - Two stage successive carotid artery occlusion surgeries in wistar rat reduce its mortality and depicts as a better model for vascular dementia. AU - Siva Kumar, G.. AU - Vidyadhar, D. J.. AU - Punja, Dhiren. AU - Rajesh, T.. AU - Reddy, Ashok P.M.. AU - Huban Thomas, R.. AU - Ramesh Babu, M. G.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Chronic cerebral hypoperfusion induced vascular dementia (VD) constitutes a major cause for dementia in the geriatric population. Permanent-bilateral common carotid artery occlusion (P-BCCAO) in Wistar rat models are considered as accepted models for preclinical research on VD. It has been documented that the P-BCCAO rats undergo a brief period of acute severe ischemia immediately following P-BCCAO surgery. This offers a significant disadvantage in using this model to study chronic cerebral hypoperfusion induced VD in human beings. Moreover, the survival rate of this rat model is relatively low compared to other animal models being used for similar ...
Shouwu is a traditional Chinese medicine (TCM) with neuroprotective effect. Shouwu Yizhi decoction (SYD) was designed based on TCM theory. However, little is known about the roles of SYD in Vascular dementia (VaD). The present study aimed to evaluate the potential effects of SYD on the vascular cognitive impairment and explore the underlying mechanism by establishing focal cerebral ischemia/reperfusion (I/R) rat model to induce VaD. SYD administration (54 mg·kg-1) for 40 days obviously improved the vascular cognitive impairment in the middle cerebral artery occlusion (MCAO) rats as evidenced by the declined neurological deficit score and shortened escape latency via neurological deficit assessment and Morris water maze test ...