Effect of interleukin-1beta and dehydroepiandrosterone on the expression of lumican and fibromodulin in fibroblast-like synovial cells of the human temporomandibular joint
Dehydroepiandrosterone (DHEA) was found to inhibit experimental cancer development in mouse and rat lung, colon and mammary gland. Since DHEA is a potent inhibitor of mammalian G-6-PD, the hypothesis that the compound could inhibit cell proliferation through an inhibition of the pentose phosphate pathway has been formulated. We studied the effects of DHEA on the proliferation in vitro of human lymphocytes induced by several mitogens (PHA, ConA and PWM), measuring 3H-thymidine uptake. DHEA inhibited 3H-thymidine uptake of mitogen-stimulated cells from both G-6-PD+ and G-6-PD- (mediterranean type deficiency) individuals in a dose-dependent and reversible fashion. The inhibitory effect was found even if DHEA was added to cells in the last hours of culture, simultaneously with the addition of 3H-thymidine. These data suggest that the inhibition of thymidine uptake induced by DHEA on human lymphocytes probably does not depend on the inhibition of G-6-PD.. ...
Type 2 diabetic patients with good glycemic control and no evidence of chronic diabetes complications, such as those enrolled in this study, show a redox imbalance characterized by increased production of highly reactive oxygen species and lower-than-normal antioxidant potential. We show here that DHEA treatment counteracts this oxidative imbalance-after 12 weeks, the concentrations of ROS and HNE were greatly reduced in both plasma and cytosol of PBMCs, whereas levels of the nonenzymatic antioxidants GSH and vitamin E were increased. These results are in agreement with the multi-targeted antioxidant effect of DHEA previously reported by our group (9,10,12). We could not find any correlation between serum DHEA or DHEAS levels and both the oxidative and the antioxidant parameters either before or after DHEA treatment. This result is not surprising, since DHEA is not a scavenger compound acting in a stoichiometric manner and exerts its antioxidants effects in a complex and non-completely defined ...
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TY - JOUR. T1 - Bovine liverslices: A multifunctional in vitro model to study the prohormone dehydroepiandrosterone (DHEA). AU - Rijk, J.C.W.. AU - Bovee, T.F.H.. AU - Peijnenburg, A.A.C.M.. AU - Groot, M.J.. AU - Rietjens, I.M.C.M.. AU - Nielen, M.W.F.. PY - 2012. Y1 - 2012. N2 - Biotransformation of inactive prohormones like dehydroepiandrosterone (DHEA) can lead to the formation of potent androgens and subsequent androgenic responses in target tissues. In the present study, precision-cut bovine liver slices were used to study the effects of DHEA on the metabolite, transcript and androgenic activity level. Bovine liver slices were exposed for 6h to various concentrations of DHEA. Changes in androgenic activity of the DHEA containing cell culture media were measured using a yeast androgen bioassay and metabolites were identified using ultra performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOFMS), while gene expression in the DHEA-treated liver slices was examined using ...
The adrenal steroid dehydroepiandrosterone (DHEA) and its sulphate ester, DHEAS are the most abundant circulating steroid hormones in humans. Uncongugated DHEA predominately exerts its effects via its downstream conversion to active sex steroids in peripheral target tissues. In contrast the conversion of DHEAS to androgens first requires cleavage of the sulfate group, catalysed by the microsomal enzyme steroid sulfatase (STS). Conversely, DHEA is converted to inactive DHEAS by the activity of the cytosolic enzyme DHEA sulphotransferase (SULT2A1). However, in addition, evidence is growing that DHEA and DHEAS can have specific, direct effects. In this thesis, I have demonstrated that abrogation of DHEA metabolism can result in the manifestation of pathophysiological conditions. SULT2A1 requires 3-phosphoadenosine-5-phosphosulfate (PAPS) for catalytic activity. I have identified compound heterozygous mutations in the gene encoding human PAPS synthase 2 (PAPSS2) in a girl with androgen excess and ...
1. van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol. 1998;25:285-289. 2. van Vollenhoven RF, Park JL, Genovese MC, et al. A double-blind, placebo-controlled, clinical trial of dehydroepiandrosterone in severe systemic lupus erythematosus. Lupus. 1999;8:181-187. 3. Mease PJ, Merrill JT, Lahita R, et al. GL701 (prasterone, dehydroepiandrosterone) improves or stabilizes disease activity in systemic lupus erythematosus. Presented at: The Endocrine Societys 82nd Annual Meeting; June 21-24, 2000; Toronto, Canada.. 4. Baulieu EE, Thomas G, Legrain S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue. Proc Natl Acad Sci USA. 2000;97:4279-4284. 5. Labrie F, Diamond P, Cusan L, et al. Effect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina and endometrium in postmenopausal women. J Clin ...
Looking for dehydroepiandrosterone? Find out information about dehydroepiandrosterone. C19H28O2 Dimorphous crystals with a melting point of 140-141°C, or leaflet crystals with a melting point of 152-153°C; soluble in alcohol, benzene, and... Explanation of dehydroepiandrosterone
6. What about other androgens, such as dehydroepiandrosterone (DHEA)? DHEA is a weak male hormone. Although it is true that DHEA levels decline with age, very few research studies show benefit from replacement. Another New England Journal of Medicine study says DHEA treatment improves sexual function in women who have underactive adrenal glands.. In addition, many people are taking DHEA in very large quantities. Excessive amounts of synthetic androgens drive down HDL cholesterol levels, which is considered a cardiovascular risk. People who are ill often have low DHEA or testosterone levels. This appears to be a normal physiological response to illness and not the cause of the illness.. Barbara L. Minton is a school psychologist and a breast cancer survivor using "alternative" treatments. She has also studied the affects of testosterone on women. The last point is taken from her research. 7. Testosterone conveys powerful anti-aging effects. It turns fat into muscle, keeps skin supple, increases ...
Purpose: Abnormalities in both cortisol and dehydroepiandrosterone (DHEA) have been reported in psychiatric disorders. measure which may reflect environmental stress. More work is required to further validate this technique which may prove useful in studies of both healthy individuals and patient groups. = 0.38) or DHEA (U = 131, = 0.88) using the two pilot extraction protocols. Cortisol was significantly correlated with DHEA at both visits (= 0.001 and 0.001, r = 0.510 and 0.583, 11056-06-7 respectively; Figures 1 and ?and2).2). The two women on combined oral hormone contraception were not outliers in any of these analyses. No traceable amounts of cortisol or DHEA were detected in methanol from the additional extraction or in isopropanol (Data not shown). Figure 1 Correlation plots of the cortisol and DHEA concentrations at baseline visit. Cortisol denotes nail cortisol levels to the beginning of the school period and DHEA denotes the nail DHEA levels to the beginning of the school period. Note ...
Dehydroepiandrosterone (DHEA) is a natural steroid hormone produced from cholesterol by the adrenal glands. DHEA is also produced in the gonads, adipose tissue, and the brain. DHEA is structurally similar to and is a precursor of, androstenedione, testosterone, estradiol, estrone, and estrogen. It is the most abundant hormone in the human body. Most of DHEA is sulfated (dehydroepiandrosterone sulfate or DHEA-S) before secretion. DHEA-S is the sulfated version of DHEA; this conversion is reversibly catalyzed by sulfotransferase (SULT2A1) primarily in the adrenals, the liver, and small intestines. In blood, most DHEA is found as DHEA-S with levels that are about 300 times higher than free DHEA. Blood measurements of DHEA-S/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have normal or mildly elevated levels of DHEA-S ...
In a rare case of double-WYHA?, the U.S. Court of Appeals for the Federal Circuit (a/k/a, the CAFC) affirmed the TTABs decision (here) upholding a refusal to register, on the ground of genericness, the terms PRASTERONE.ORG and THE PRASTERONE COMPANY for "providing a website featuring scientific and clinical research information about investigational medical foods, dietary supplements or drugs, namely, prasterone or derivatives or analogs thereof." In Re Health Science Funding, LLC, Appeal No. 1054 (Fed. Cir. September 13, 2013) [not precedential ...
1. Wolf OT, Naumann E, Hellhammer DH, et al. Effects of dehydroepiandrosterone replacement in elderly men on event-related potentials, memory, and well-being. J Gerontol. 1998;53:M385-M390. 2. Wolf OT, Neumann O, Hellhammer DH, et al. Effects of a two-week physiological dehydroepiandrosterone substitution on cognitive performance and well-being in healthy elderly women and men. J Clin Endocrinol Metab. 1997;82:2363-2367. 3. Barnhart KT, Freeman E, Grisso JA, et al. The effect of dehydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J Clin Endocrinol Metab. 1999;84:3896-3902. 4. Flynn MA, Weaver-Osterholtz D, Sharpe-Timms KL, et al. Dehydroepiandrosterone replacement in aging humans. J Clin Endocrinol Metab. 1999;84:1527-1533. 5. van Niekerk JK, Huppert FA, Herbert J. Salivary cortisol and DHEA: association with measures of cognition and well-being in normal older men, and effects of three ...
Dehydroepiandrosterone (DHEA) is a natural steroid prohormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue, brain and in the skin (by an autocrine mechanism). DHEA is the precursor of androstenedione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol. DHEA is also a potent sigma-1 agonist. DHEA is produced from cholesterol through two cytochrome P450 enzymes. Cholesterol is converted to pregnenolone by the enzyme P450 scc (side chain cleavage); then another enzyme, CYP17A1, converts pregnenolone to 17α-Hydroxypregnenolone and then to DHEA. In humans, DHEA is the dominant steroid hormone and precursor of all sex steroids. DHEA can be understood as a prohormone for the sex steroids. DHEAS may be viewed as buffer and reservoir. As most DHEA is produced by the zona reticularis of the adrenal, it is argued that there is a role in the immune and stress response. Studies have shown that DHEA is useful in ...
TY - JOUR. T1 - Gradient HPLC separation of dehydroepiandrosterone (DHEA) from its metabolites and biological congeners. T2 - Role of tetrahydrofuran in the chromatographic mechanism. AU - Gergely, András. AU - Horváth, Péter. AU - Szász, György. AU - Veress, Gábor. PY - 2009/8/1. Y1 - 2009/8/1. N2 - A three-step gradient reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed for the separation of dehydroepiandrosterone (DHEA), its sulfate ester (DHEA-S), its three C7-oxidized metabolites (7αOH-DHEA, 7βOH-DHEA, 7-keto-DHEA), and its biosynthetic congeners (androstenedione, testosterone, estradiol, pregnenolone). This new method allows the quantitative characterization of DHEA metabolism and biosynthetic transformation under given physiological, pathological, or therapeutically influenced circumstances. Tetrahydrofuran probably acts as a proton acceptor coadsorbent, while isopropanol behaves as a proton donor during the separation of testosterone, estradiol, ...
Biotransformation of inactive prohormones like dehydroepiandrosterone (DHEA) can lead to the formation of potent androgens and subsequent androgenic responses in target tissues. In the present study, precision-cut bovine liver slices were used to study the effects of DHEA on the metabolite, transcript and androgenic activity level. Bovine liver slices were exposed for 6h to various concentrations of DHEA. Changes in androgenic activity of the DHEA containing cell culture media were measured using a yeast androgen bioassay and metabolites were identified using ultra performance liquid chromatography time-of-flight mass spectrometry (UPLC-TOFMS), while gene expression in the DHEA-treated liver slices was examined using bovine microarrays and compared with the profile as obtained with 17ß-testosterone (17ß-T ...
Dehydroepiandrosterone(DHEA) is a 19-carbon endogenous natural steroid hormone. Find all the information about Dehydroepiandrosterone(DHEA) for cell signaling research.
New research by Dr. Mark Jacobson and colleagues at the University of California at San Francisco now indicates that low blood levels of the steroid hormone dehydroepiandrosterone (DHEA) appear to precede the progression of asymptomatic HIV infection to full-blown AIDS. Their study, based on blood samples taken from 108 participants of the San Francisco Mens Study, showed that low levels of DHEA were associated with a doubled chance of progressing into full-blown AIDS within a 3-year period compared to those with normal DHEA levels. This observation was noted after taking into account the influence of such factors as CD4 counts and whether or not antiviral drugs such as AZT had been used.. DHEA is an abundant steroid hormone that is produced by the adrenal glands. It is a vital steroid precursor to both male and female steroid hormones. Despite three decades of research into DHEA, its importance and function beyond that of steroid precursor remains something of a mystery. DHEA undergoes the ...
Dehydroepiandrosterone (DHEA) administered at a dose of 25 mg tid po. DHEA is a weak androgen produced naturally by the adrenal in men and women. DHEA production is diminished with increasing age. Peak levels of DHEA occur in the late teenage years ...
Context: The age-related decline in dehydroepiandrosterone (DHEA) levels is thought to be of importance for general and vascular aging. However, data on the association between DHEA and mortality are conflicting. Objectives: We tested the hypothesis that low serum DHEA and DHEA sulfate (DHEA-S) levels predict all-cause and cardiovascular disease (CVD) death in elderly men. Design, Setting, and Participants: We used gas/liquid chromatography-mass spectrometry to analyze baseline levels of DHEA and DHEA-S in the prospective population-based MrOS Sweden study (2644 men, aged 69-81 yr). Mortality data were obtained from central registers and analyzed using Cox proportional hazards regressions. Main Outcome Measures: All-cause and CVD mortality by serum DHEA(-S) levels. Results: During a mean 4.5-yr follow-up, 328 deaths occurred. Low levels of DHEA-S (quartile 1 vs. quartiles 2-4), predicted death from all causes [hazard ratio (HR) 1.54, 95% confidence interval (CI) 1.21-1.96; adjusted for ...
DHEADehydroepiandrosterone (pronounced dee-hi-dro-epp-ee-ann-dro-stehr-own), or DHEA as it is more often called, is a steroid hormone produced in the adrenal gland. It is the most abundant steroid in the bloodstream and is present at even higher levels in brain tissue. Dehydroepiandrosterone levels are known to fall precipitously with age, falling 90% from age 20 to age 90. DHEA is known to be a precursor to
Chemicals. Radiolabeled [4-14C]fluasterone (lot 9676-29-07 from Midwest Research Institute, Kansas, MO) had a radiochemical purity of approximately 97% and specific activity of 58.3 mCi/mmol. Fluasterone (lot 99973-1/91) was supplied by Proquina (Orizaba, Mexico). Standards of 16α-fluoro-5-androsten-17β-ol (17β-OH fluasterone) and 16α-fluoro-5-androsten-17α-ol (17α-OH fluasterone) were supplied by Dr. Marvin L. Lewbart (Department of Medicine, Jefferson Medical College, Philadelphia, PA). Sulfatase-free β-glucuronidase, bacterial from Escherichia coli, was supplied with phosphate buffer Sigma G8396 (Sigma-Aldrich, St. Louis, MO). β-Glucuronidase-free sulfatase, type VI, from Aerobacter aerogenes was supplied with 0.01 M Tris, pH 7.5, Sigma S1629 (Sigma-Aldrich). Soluene-350 tissue solubilizer and Ultima Gold scintillation mixture were purchased from PerkinElmer Life and Analytical Sciences (Waltham, MA).. Dosing and Collection of Biological Samples. Groups of male beagle dogs received ...
Abstract Background: DHEA stimulates endothelial nitric oxide (NO) production in vitro and its prolonged use in humans improves vascular function. It is believed that this effect is mediated by metabolism of DHEA to
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DHEA supplement benefit side effects, dosage 5 mg 10 mg 25 mg, 50 mg memory, libido, hair loss, prostate. Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone. It is one of the most abundant circulating steroids in.. Sep 24, 2012. 7-Keto DHEA vs DHEA. "DHEA" stands for "dehydroepiandosterone." It is a hormone synthesized in the human body naturally. 7-Keto DHEA is a metabolite product which is derived from the hormone DHEA. They are similar in structure but have many different functions and properties. DHEA. DHEA is a.. The adrenal glands produce dehydroepiandrosterone, or DHEA, the most plentiful hormone in your bloodstream. Your body produces sufficient amounts until.. Gain 7 pounds in 7 days! Walk into any vitamin store and youll. The first two supplements in the slideshow below -.. Keto DHEA, also known as 7-Keto, is a metabolite of DHEA. But because Keto DHEA does not break down into the sex hormones estrogen or testosterone, many of the side ...
Low prices on DHEA! DHEA may help prevent the onset of symptoms related to the aging process*. DHEA (dehydroepiandrosterone) is a hormone produced in the body and secreted by the adrenal glands. DHEA levels can decline as we age. DHEA can be converted to testosterone and estrogen as needed depending on your gender, age, or health status.*
The polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder with pathological mechanisms remain unclear. The following study investigates the ovarian hyperfibrosis forming via transforming growth factor-β (TGF-β) signaling pathway in Dehydroepiandrosterone (DHEA)- induced polycystic ovary syndrome (PCOS) rat model. We furthermore explored whether TGF-βRI inhibitor (SB431542) decreases ovarian fibrosis by counterbalancing the expression of fibrotic biomarkers. Thirty female Sprague-Dawley rats were randomly divided into Blank group (n = 6), Oil group (n = 6), and Oil + DHEA-induced model group (n = 6 + 12). The model groups were established by subcutaneous injection of DHEA for 35 consecutive days. The 12 successful model rats were additionally divided in vehicle group (n = 6) and SB431542-treated group (n = 6). Vehicle group and SB431542-treated group, served as administration group and were intraperitoneally injected with DMSO and SB431542 for additional 14 consecutive days.
Delta-isomerase 2 (HSD3B2) which catalyzes the conversion of Dehydroepiandrosterone (DHEA) to androstenedione, a critical step in producing DHT from adrenal androgens, is also overexpressed at high levels [201]. Taken together, these data suggest a mechanism for how MCRPCa cells can continue to upregulate genes that require AR transactivation. The most obvious argument against this model is that t
The hormone dehydroepiandrosterone (DHEA) plays a role in sexual function, and also acts as precursor to other hormones like estrogen and testosterone. Symptoms of low DHEA levels may include low libido, fatigue, and depression. DHEA hormone replacement therapy is available in Canton, GA.
The hormone dehydroepiandrosterone (DHEA) helps maintain several bodily functions like metabolism, the reproductive process, and mood. Low DHEA levels may cause symptoms like obesity, depression, and memory loss. DHEA hormone replacement is available in Austell, GA.
Sodium Prasterone Sulfate Hydrate is a medicine available in a number of countries worldwide. A list of US medications equivalent to Sodium Prasterone Sulfate Hydrate is available on the Drugs.com website.
Read this manual carefully, for example in food interaction section provided you will find the information about economic interaction of furosemide and increase potassium intake ; add a banana or without orange juice ; unless otherwise instructed me otherwise. Available data are insufficient to show love that rocuronium hydrochloride and the furosemide tablets USP do see not have a similar risk. I have chemists been taking prasterone, now furosemide. One of the most famous as manufacturers association of the furosemide is sanofi aventis us llc. H and h laboratories is a reputed company offering furosemide. Major reasons contributing columnist to the low plasma and tissue prostaglandin levels have of g17dt and prasterone appear to be retired due to poor absorption, rapid liver metabolism, and rapid and systemic elimination. In the dosage may range for which Lasix special tablets 500mg is sufficiently approved, furosemide produces typical opioid agonist effects. The key ingredient in the ...
Prasterone is a medicine available in a number of countries worldwide. A list of US medications equivalent to Prasterone is available on the Drugs.com website.
Increased lipid utilization in weight losing and weight stable cancer patients with normal body weight. Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year
Synonyms for 4-dehydroepiandrosterone are: 3β-Hydroxy-4-androsten-17-one, 3β-hydroxyandrost-4-en-17-one, 3β-hydroxy-D4-androsten-17-one, 3β-hydroxyandrost-4-en-17-one, 3β-hydroxy-etioallocholan-4-en-17-one, and 4-androsten-3β-ol-17-one. ...
History With infertility populations in the developed world rapidly aging treatment of diminished ovarian reserve TGX-221 (DOR) assumes increasing clinical importance. publications were further explored for additional relevant citations. Since only one randomized study has been published publications impartial of evidence levels and quality assessment were examined. Results Current best available evidence suggests that DHEA enhances ovarian function raises pregnancy probabilities and by reducing aneuploidy lowers miscarriage rates. DHEA over time also appears to objectively improve ovarian reserve. Recent Rabbit Polyclonal to NMBR. animal data support androgens in promoting preantral follicle growth and reduction in follicle atresia. Conversation Improvement of oocyte/embryo quality with DHEA supplementation potentially suggests a new concept of ovarian ageing where ovarian environments but not oocytes themselves age. DHEA may therefore represent a first agent beneficially influencing ageing ...
This topic has 37 study abstracts on DHEA (Dehydroepiandrosterone) indicating that it may have therapeutic value in the treatment of Lupus Erythematosus: Systemic, Systemic Lupus Erythematosus, and Adrenal Insufficiency
Dehydroepiandrosterone, or DHEA, is a naturally occurring hormone that may promote brain health, muscle growth, and energy. It is secreted by the adrenal gland and serves as a precursor to testosterone and estrogen.. ...
Dehydroepiandrosterone, or DHEA, is a naturally occurring hormone that may promote brain health, muscle growth, and energy. It is secreted by the adrenal gland and serves as a precursor to testosterone and estrogen.. ...
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Dehydroepiandrosterone (DHEA) is synthesized in the adrenals and the brain. Additionally, DHEA is produced at high concentrations in the human embryo enhancing neuronal development. Its production...
Dehydroepiandrosterone (DHEA) is a steroid produced in the adrenal glands. It is converted in the body to testosterone and estrogen and acts similarly to ...
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The IUPHAR/BPS Guide to Pharmacology. dehydroepiandrosterone ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
Administering the hormone dehydroepiandrosterone (DHEA) to diabetics helps prevent oxidative stress and advanced glycation end product (AGE) formation.
A review of the published scientific literature reveals that DHEA (dehydroepiandrosterone) may be the best-validated anti-aging supplement currently available.
Prasterone is a naturally occurring steroid hormone secreted by the adrenal cortex and is an androgen precursor. Jenapharm (Schering AG) has conducted clinical
Effect of acute DHEA administration on free testosterone in middle-aged and young men following high-intensity interval training. Authors Liu TC, et...
A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion. . ...