Causes of Sads - Sudden arrhythmic death syndrome - conditions responsible for SADS cause a cardiac arrest by bringing on a disturbance in the hearts rhythm, even though there is no structural heart disease

SADS UK - Preventing loss of life from Sudden Arrhythmic Death Syndrome (SADS) and highlighting cardiac risk in the young through to middle age.

The articles are based on the findings of a large, well-conducted case-control study from the Netherlands (8). This compared 775 cases of sudden cardiac death with 6,297 matched controls, with respect to the use of seven drugs (two antibiotics, two stomach and three antipsychotic medications). This found a significantly increased risk of sudden cardiac death for current users (by three times), particularly those with less than 90 days use (by four times) compared with non-users. * Most newspapers reported the research fairly accurately but three (1,6,7) incorrectly stated that the drugs were responsible for 320 of the 775 sudden cardiac deaths in the study, when the authors report that they may be linked to 320 cases per year in the Netherlands, based on the rate of sudden cardiac death in the study. They all reported that the researchers state that patients taking these drugs should not stop taking them without consulting their GP. Evaluation of the evidence base for the association between the ...

BACKGROUND--Although heart rate variability has already been studied in survivors of sudden cardiac death secondary to coronary artery disease, an assessment of heart rate variability in survivors of sudden cardiac death not associated with coronary artery disease has not been made. METHODS--10 patients with aborted sudden cardiac death not associated with coronary artery disease (seven patients with primary ventricular fibrillation and three with unclassified mild cardiomyopathy) underwent two channel 24 hour Holter monitoring in a drug free state. All subjects were in sinus rhythm and had normal atrioventricular conduction and normal cardiac function. Spectral heart rate variability was analysed on a Holter analysis system and was expressed as total (0.01-1.00 Hz), low (0.04-0.15 Hz) and high (0.15-0.40 Hz) frequency components for each hour. Heart rate variability index was calculated for the 24 hour periods. 10 age and sex matched healthy subjects were taken as a control group. RESULTS--The ...

TY - JOUR. T1 - The association between atrial fibrillation and sudden cardiac death. T2 - The relevance of heart failure. AU - Reinier, Kyndaron. AU - Marijon, Eloi. AU - Uy-Evanado, Audrey. AU - Teodorescu, Carmen. AU - Narayanan, Kumar. AU - Chugh, Harpriya. AU - Gunson, Karen. AU - Jui, Jonathan. AU - Chugh, Sumeet S.. PY - 2014. Y1 - 2014. N2 - Objectives: The purpose of this study was to evaluate the role of congestive heart failure (CHF) in the association between atrial fibrillation (AF) and sudden cardiac death (SCD). Background: Recent studies have reported the possibility of an independent association between AF and SCD. We hypothesized that a history of CHF is a significant confounder of this association. Methods: In a prospective case-control analysis from the community (The Oregon-SUDS [Sudden Unexpected Death Study], 2002 to 2012), SCD cases (n = 652) with clinical records available (including electrocardiography and/or echocardiography) were compared with age- and sex-matched ...

Sudden cardiac death can occur when someone in sudden cardiac arrest is not treated promptly. Sudden cardiac arrest occurs when the hearts electrical system malfunctions and the heart suddenly stops beating ? often without warning. While the terms sudden cardiac arrest and heart attack are often used as if they are synonyms, they arent. Sudden cardiac arrest can occur after a heart attack, or during recovery. Heart attacks increase the risk for sudden cardiac arrest, but most heart attacks do not lead to sudden cardiac arrest. Immediate CPR can double or triple the chances of survival from sudden cardiac arrest. ...

We assessed risk factors for sudden coronary death among persons without a history of coronary heart disease (unexpected sudden coronary death) and persons with a history of coronary heart disease (sudden coronary heart disease death). We analyzed national data to calculate death rates and odds rati …

Title: Regulation of Cardiac Nerves: A New Paradigm in The Management of Sudden Cardiac Death?. VOLUME: 15 ISSUE: 17. Author(s):Masaki Ieda, Kensuke Kimura, Hideaki Kanazawa and Keiichi Fukuda. Affiliation:Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi,Shinjuku-ku, Tokyo 160-8582, Japan.. Keywords:Heart, cardiac nerve, nerve growth factor, Sema3a, arrhythmia, sudden cardiac death. Abstract: The heart is extensively innervated, and its performance is tightly regulated by the autonomic nervous system. To maintain cardiac function, innervation density is stringently controlled, being high in the subepicardium and the central conduction system. In diseased hearts, cardiac innervation density varies, which in turn leads to sudden cardiac death. After myocardial infarction, sympathetic denervation is followed by reinnervation within the heart, leading to unbalanced neural activation and lethal arrhythmia. Diabetic sensory ...

Research Paper Title Sudden Cardiac Death in Athletes. Abstract Sudden cardiac death is defined as an unexpected death, occurring usually within one hour from onset of symptoms in cases where the death is witnessed and in unwitnessed cases within 24 hours of the individual last being seen alive and well. Sudden cardiac death in athletes is the leading…

Heart structural gene causes sudden cardiac death in animal model The presence or absence of the CAP2 gene causes sudden cardiac death in mice. In particular, the absence of the gene interrupts the animals ability to send electrical signals to the heart to tell it to contract, a condition called cardiac conduction disease. Since humans have the same CAP2 gene, what we learn from the mice could advance our understanding of heart disease. ...

The Royal College of Pathologists have published guidelines on autopsy practice as a new set of standardised best practice scenarios. Scenario 1 (sudden death with likely cardiac pathology) was issued in 2005.1 The intention of the College Working Party on the Autopsy was that the scenarios would be periodically reviewed, updated and augmented.2 There is a need to place cannabis, nicotine, non-steroidal anti-inflammatory drugs (NSAIDs) and psychology in the proper context when reporting on cardiac deaths. The rationale follows.. In the list of drugs, both licit and illicit, which may cause sudden cardiac death is marijuana. The sentinel paper on cannabis as a trigger for sudden cardiac death is a case crossover study from Mittleman et al, which reported that the elevated risk of triggering myocardial infarction is limited to about the first 2 h after smoking cannabis.3 The RR of infarction was increased by 3.2 in the first hour if confounders were excluded. In the second hour, the RR was 1.7. ...

Sudden cardiac death, which occurs when the heart unexpectedly stops, was second only to AIDS as a leading cause of death among HIV patients in a new ...

Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with left ventricular (LV) systolic dysfunction. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of LV ejection fraction (LVEF)≤35% as the main determining factor for patient selection, only a minority of patients actually benefit from ICD therapy (,25% in 5 years). There is an essential need for more robust diagnostic approaches to SCD risk stratification.. This project examines the hypothesis that LV structural abnormalities above and beyond global LV dysfunction are important predictors of SCD risk since they indicate the presence of abnormal pathophysiologic substrate required for the ventricular arrhythmogenicity leading to SCD. This premise is supported by ...

Survival rates of out-of-hospital sudden cardiac arrest doubled with the use of a new resuscitation protocol, reports a study in the May 19 issue of Circulation. Despite resuscitation efforts by emergency medical services (EMS), as many as 450,000 people die of sudden cardiac arrest each year in the United States. The new protocol instructs EMS personnel to raise the compression-to-ventilation ratio from the previously recommended 5:1 to 50:2 and to delay intubation, thereby increasing spontaneous circulation. The survival rate increased from 22% under the old resuscitation method to 44% with the new protocol. Moreover, most patients had a good neurologic outcome. ...

Being overweight or obese throughout adulthood, especially during early adulthood, may lead to an increased risk of sudden cardiac death, according to a study published Nov. 25 in JACC: Clinical Electrophysiology.. Researchers led by Stephanie Chiuve, ScD, an assistant professor of medicine at Harvard Medical School, analyzed data from the Nurses Health study, following 72,484 healthy women from 1980 to 2012. Over the study period, researchers documented 445 cases of sudden cardiac death, 1,286 cases of fatal coronary heart disease, and 2,272 non-fatal myocardial infarction (MI). Results showed women who were overweight (body mass index [BMI] 25-30) and obese (BMI 30 or greater) were 1.5- and 2-times more likely, respectively, to experience sudden cardiac death over the next two years as compared to women with a healthy weight (BMI 21-23).. Further, women who were overweight or obese at the start of the study or obese at age 18 had an elevated risk of sudden cardiac death over the entire course ...

HearTwave II Microvolt T-Wave Alternans System With Analytic Spectral Method,The HearTwave II system is the Cambridge Heart next generation Microvolt T-Wave Alternans (MTWA) testing platform which simplifies hospital and office-based sudden cardiac death risk stratification. This new system offers expanded versatility as it can be configured to perform MTWA and/or standard,medicine,medical supply,medical supplies,medical product

A leading cause of death in western countries is sudden cardiac death, and can be associated with genetic disease. Next-generation sequencing has allowed thorough analysis of genes associated with this entity, including, most recently, titin. We aimed to identify potentially pathogenic genetic variants in titin. A total of 1126 samples were analyzed using a custom sequencing panel including major genes related to sudden cardiac death. Our cohort was divided into three groups: 432 cases from patients with cardiomyopathies, 130 cases from patients with channelopathies, and 564 post-mortem samples from individuals showing anatomical healthy hearts and non-conclusive causes of death after comprehensive autopsy. None of the patients included had definite pathogenic variants in the genes analyzed by our custom cardio-panel. Retrospective analysis comparing the in-house database and available public databases also was performed. We identified 554 rare variants in titin, 282 of which were novel. Seven were

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Physically and psychologically stressful law enforcement duties are associated with large increases in the risk of sudden cardiac death compared with routine/non-emergency policing activities. To our knowledge our study is the first to show an association between specific law enforcement duties and risk of sudden cardiac death-a finding that supports the hypothesis that stressful work related activities can trigger sudden cardiac death and is consistent with our previous studies of on duty acute cardiac deaths among firefighters.14 15 16 In addition, our finding that up to 10% of all on duty deaths during law enforcement are sudden cardiac deaths represents the most accurate estimate to date of the proportionate mortality from sudden cardiac death in this population.. While routine/non-emergency duties constituted about 75% of police work time, 77% of sudden cardiac deaths occurred during non-routine tasks. Physical restraints and altercations comprised about 1-2% of a police officers annual ...

When the heart experiences a disturbance that disrupts its pumping action it ceases blood flow to the rest of the body, which triggers a sudden, unexpected loss of heart function, breathing, and consciousness. This is known as sudden cardiac arrest.. Sudden cardiac arrest differs from a heart attack. Heart attacks occur when blood flow to a portion of the heart is blocked. However, heart attacks can spur a disturbance that leads to sudden cardiac arrest. Sudden cardiac arrest is a dire situation and requires immediate attention. Fast, appropriate care increases survival odds. With it being Sudden Cardiac Arrest Awareness Month, lets delve into what that fast, appropriate care looks like and how to recognize if someone is experiencing this traumatic event.. Symptoms are drastic and immediate. Someone experiencing sudden cardiac arrest collapses, loses a pulse, stops breathing, and is unconscious. Occasionally there are visible symptoms that precede sudden cardiac arrest, such as: fatigue, ...

Bridget McAnallen was speaking at the publication of a report on sudden cardiac death which coincided with the second anniversary of her sons death. She said screening of young people participating in sport was essential as it could alert them of the need to alter or regulate their lifestyle.. However, a special task force on sudden cardiac death has advised the Government that there is insufficient evidence to support the introduction of a mass population screening programme. It is estimated that 5,000 Irish people die from sudden cardiac death each year, including 60 people under the age of 40.. The task force was established in 2004 following public concern about the death of several high-profile young sports stars including Cormac McAnallen. However, the task force claimed that mass population screening programmes could lead to large numbers of normal young people being needlessly excluded from participating in sport and physical activity.. Chairman of the task force, Dr Brian Maurer of the ...

Sudden cardiac arrest is not a heart attack (myocardial infarction). Learn more about sudden cardiac death, symptoms, causes, risk factors, treatment and prevention measures - Cleveland Clinics Heart and Vascular Institute specializes in heart care for patients facing all manner of valvular and vascular heart issues as well as other heart disorders.

For general clinical purposes, the term sudden cardiac death is usually reserved for those deaths in which the patient had stable cardiac function until the terminal event, with death occurring within a short time (often defined as less than 1 hour) of the onset of symptoms. Some experts prefer the term instantaneous death, namely, death with immediate collapse without preceding symptoms. Instantaneous death is usually assumed to be due to a primary arrhythmia, but other catastrophic events, such as a massive pulmonary embolism, the rupture of an aortic aneurysm, or a stroke, can also cause instantaneous death. It is also important to note that not all arrhythmic deaths are sudden. For example, a patient who is resuscitated from a cardiac arrest may die days or weeks later from complications of the arrest. This death would be due to an arrhythmia but would not meet the standard time-based definition for instantaneous or sudden death. ...

Serious ventricular arrhythmias account for the majority of sudden cardiac death after acute myocardial infarction (MI), and identification and treatment of patients at risk of sudden cardiac death remains a major focus of clinical practice (4). Implantable cardioverter defibrillators (ICD) have been the mainstay of therapy for this condition and are currently indicated in patients with reduced cardiac systolic function, based on a left ventricular ejection fraction (LVEF) ,35%. Although ICD is effective in reducing the occurrence of sudden cardiac death the device never delivers therapy in a large proportion of recipients of an ICD based on reduced LVEF. Also, the majority of patients who die suddenly would not have qualified for ICD under current LVEF-based guidelines (5).. While a depressed LVEF portends a poor outcome, the accuracy of prediction of sudden cardiac death with LVEF alone is moderate to low. In the post-infarct setting, several studies have additionally focused on the electrical ...

Introduction: Association between early repolarization (ER) on ECG and sudden cardiac arrest (SCA) risk has been suggested by epidemiologic studies with variable prognostic results. This association has not been investigated in autopsy-proven sudden cardiac deaths (SCDs).. Methods: All pre-arrest ECGs performed as part of medical care were obtained and reviewed for ER on all resuscitated SCAs and all out-of-hospital (OOH) SCDs in San Francisco (SF) between 2/1/2011 and 3/1/2014 captured through active surveillance of all deaths reported to the Office of the Chief Medical Examiner as part of the SF Postmortem Systematic Investigation of Sudden Cardiac Death (POST SCD) study. All contemporaneous citywide resuscitated SCAs were identified via responding SF Fire Department paramedic records and cause of death was adjudicated after review of autopsy, toxicology, histology, and medical records. ER was defined as elevation of QRS-ST junction ≥ 0.1mV in ≥ 2 contiguous inferior or lateral leads, ...

Sudden cardiac death (SCD) is an important public-health problem with multiple etiologies, risk factors, and changing temporal trends. Substantial progress has been made over the past few decades in identifying markers that confer increased SCD risk at the population level. However, the quest for pr …

Some[who?] say that the Hmong who died were killed by their own beliefs in the spiritual world, otherwise known as, Nocturnal Pressing Spirit Attacks. In Indonesia it is called digeuton, which translates to pressed on in English.[8] In China it is called bèi guǐ yā (traditional Chinese: 被鬼壓; simplified Chinese: 被鬼压) which translates to crushed by a ghost in English.[8] The Dutch call the presence a nachtmerrie, the night-mare.[8] The merrie comes from the Middle Dutch mare, an incubus who lies on peoples chests, suffocating them. This phenomenon is well known among the Hmong people of Laos,[16] who ascribe these deaths to a malign spirit, dab tsuam (pronounced da cho), said to take the form of a jealous woman. Hmong men may even go to sleep dressed as women so as to avoid the attentions of this spirit.[citation needed]. During the 1970s and 1980s, when an outbreak of this syndrome began, many of the Southeast Asians were not able to worship properly due to the ...

Studies of some children with a rare developmental problem, called 6p22 syndrome, hint that this gene is associated with similar cardiac issues in people. These children have deep-set eyes and cardiac problems that are not well defined. Almost all of these children are born with a deletion of one of their copies of the CAP2 gene, Field noted.. Knowing this connection, the researchers generated mice that would exhibit only cardiac conduction disease (CCD). They reinstated the gene but this time engineered it so they could knock it out again, but this time only in the hearts of the mice. It took close to five years to perfect this mouse model that exhibited only the heart knockout, Field said. The researchers could then conduct experiments targeting only the heart problem, because all the other symptoms, such as the eye problems, were out of the picture.. The mice once again developed CCD, leading to sudden cardiac death from complete heart block, but there was an extra surprise this time. The ...

Research has suggested that heart and kidney disease play greater roles as risk factors for sudden cardiac death in patients with diabetes. Originally, diabetic autonomic neuropathy was always believed the main risk factor. The study involved 462 patients with diabetes who were followed for 15 years. Of the patients, the researchers documented 21 cases of sudden cardiac death. Reporting in the Journal of Neurology, Neurosurgery, and Psychiatry (February 2005), the researchers found that heart disease, including plaques in the blood vessels feeding the heart and heart attacks, was the biggest risk for sudden cardiac death. The researchers noted that all of the participants who died had some amount of plaque buildup. Kidney disease was also found as a key risk factor for the sudden cardiac death. ...

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Suzanne Lowrys son, Max, died suddenly on the eve of his wedding. A year on, his mother shares her sense of loss - and her hope that others may be spared the same fate

Cambridge Heart develops and commercializes non-invasive diagnostic tests for cardiac disease, with a focus on identifying those at risk for sudden cardiac arrest (SCA). The Company?s products incorporate proprietary Microvolt T-Wave Alternans measurement technologies including the patented Analytic Spectral Method? and ultrasensitive disposable electrode sensors. Medicare reimburses the Analytic Spectral Method? under its National Coverage Policy. Cambridge Heart, founded in 1990, is based in Tewksbury, MA. The company?s Microvolt T-Wave Alternans? (MTWA) test, developed by Cambridge Heart (OTCBB: CAMH), is based on research originally conducted at the Massachusetts Institute of Technology. http://www.cambridgeheart.com,http://www.cambridgeheart.com/, .. Statements contained in this press release are forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. In some cases, we use words such as ?believes?, ?expects?, ...

Cardiologist Dr Christian Wolpert, from the University Hospital Mannheim, Germany, (along with Drs Auricchio and Vardas) has researched the current status of cardiac electrophysiology in member countries of the European Society of Cardiology (ESC).. Overall in the emerging economies of ESC member countries, says Dr Wolpert, we have found great disparity in access to anti-arrhythmic therapy, for a variety of reasons. The implant rates and number of treating centres and physicians certainly correlate with the economic status of their countries and budget restrictions. However, even in countries with a higher GDP and where device therapy could be implemented, we have found low awareness, a lack of information and few treating specialist, all of which leads to severe under-treatment. A higher uptake of device therapy could save many sudden cardiac deaths.. An analysis of ICD use in ESC member countries (published by the EHRA in the 2010 White Book)(2) shows a great difference in the number of ...

Sudden cardiac death in young athletes is very rare. The estimated yearly rate varies from one country to another, however. In the United States, it i

Introduction: Sudden cardiac death in young adults is rare and since existing studies have few subjects, there is a lack of detailed information. We hypothesized that analysis from a large community-based investigation would provide novel mechanistic information.. Methods: In an ongoing, community-based study of prospectively-identified SCD cases in the Northwest US (2002 - 2011), cases aged 18 - 34 were compared with patients aged 35 - 59, and 60 or older. All cases were adjudicated by review of arrest circumstances and physician records. Cases with non-cardiac causes of SCD and terminal illnesses were excluded. Clinical history prior to arrest across the three age groups was compared using χ2 tests.. Results: Patients aged 18-34 (n=134, 59% male) made up 5% of the total 2740 cases ascertained, while patients aged 35-59 made up 36% (n=996, 75% male) and patients 60 or older made up 59% (n=1610, 62% male). Young patients were less likely to have physician records available for review (51% vs. ...

AD-arrhythmogenic dysplasia, N-normal, CMC-cardiomyocyte, DD-diastolic dysfunction, IC-inflammatory changes, LVOTO-left ventricular outflow tract obstruction, MF-myocardial fibrosis, SD-systolic dysfunction, VA-vagotonic adaptation, Myocardial fatigue refers to moderately expressed systolic and/or diastolic dysfunction. Sudden cardiac death associated with cardiac hypertrophy, exercises and other factors. Sports-related SCD is usually defined as sudden and unexpected death occurred during, or shortly after, exercise (with varying time intervals up to 24 hours) (13, 44, 45]. In fact, SCD is not a newly discovered condition in sports cardiology. Beside the creating a challenge for sports physicians and mass media, SCD influences the career of competitor and whole sports politics.. According to recent data, SCD incidence fluctuates from 0.75 in 100 000 to 1 in 40 000 and 1 in 80 000 athletic populations (46, 47]. It can be explained by variety of sports discipline, and overall health status of an ...

Sudden cardiac death (SCD) remains a major cause of mortality in the US. While the prophylactic implantable defibrillator has significantly reduced the incidenc...

Sudden cardiac death is the most common mode of death in this country with more than 300,000 deaths per year, a third of which occur during physical activity. It is estimated that approximately 1,000 children die of sudden death each year.

Aims: This study sought to confirm the efficacy of resting 12-lead ECG alongside personal symptom and family history questionnaire and physical examination when screening for diseases that have the potential of causing sudden cardiac death in the young. Methods and Results: One thousand and seventy four National and International junior athletes (15.8 ± 0.7 years, range 10-27) and 1646 physically active school children (16.1 ± 2.1 years, range 14-20) were screened using personal and family history questionnaires, physical examination and resting 12-Lead ECG. Nine participants with a positive diagnosis of a disease associated with sudden cardiac death were identified. None of the participants diagnosed with a disease associated with sudden cardiac death were symptomatic or had family history of note. Conclusion: Family history and personal symptom questionnaires alone are inadequate in the identification of individuals with diseases associated with sudden cardiac death. Utilisation of 12-lead ...

Urgency. Sudden cardiac death (SCD) still remains a leading cause of death in patients after MI. Because of the fluminant nature of SCD prediction of this event has acquired high priority. Aim. This study was focused on assessing the predictive significance of LV EF and other prognostic factors for SCD in patients after IM. Materials and methods. 420 patients after IM were evaluated; mean follow-up period was 2.6 years. Using multifactor regression analysis predictive effects of 194 factors on risk of SCD were evaluated. Results. Reduced LV EF was an important risk factor for SCD as it reflected not only the impaired LV contractility but also the arrhythmogenic substrate, processes of postinfarction remodeling and to a certain extent triggers of malignant arrhythmias. The LV EF predictive value increased when this parameter was used in combination with other echoCG parameters and also with such prognostic factors as ventricular arrhythmias, heart rhythm variability and data of an active ...

TY - JOUR. T1 - Genetic determinants of sudden cardiac death. AU - Noseworthy, Peter. AU - Newton-Cheh, Christopher. PY - 2008/10/28. Y1 - 2008/10/28. KW - Death, sudden. KW - Epidemiology. KW - Genetics. KW - Heart arrest. KW - Tachyarrhythmias. UR - http://www.scopus.com/inward/record.url?scp=56549109039&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=56549109039&partnerID=8YFLogxK. U2 - 10.1161/CIRCULATIONAHA.108.783654. DO - 10.1161/CIRCULATIONAHA.108.783654. M3 - Review article. C2 - 18955676. AN - SCOPUS:56549109039. VL - 118. SP - 1854. EP - 1863. JO - Circulation. JF - Circulation. SN - 0009-7322. IS - 18. ER - ...

As many as 450,000 Americans die every year from a sudden, fatal heart condition, and in slightly more than 1 in 10 cases the cause remains unexplained even after an autopsy. Researchers from the University of Maryland School of Medicine (UMSOM) and their colleagues found that nearly 1 in 5 patients with unexplained sudden cardiac death -most of whom were under age 50.

Young athletes should all be screened for sudden cardiac death prior to participation in sports. Heres what parents need to know.

The American College of Preventive Medicine (ACPM) supports an evaluation prior to participating in high school and collegiate sports using a standardized history and physical (H&P) (i.e., using standardized items as developed by the American Heart Association [AHA] to ensure uniformity and consistency in risk factor assessment [see the table below]). ACPM recommends against routine screening for potential sudden cardiac death (SCD) with electrocardiogram (ECG), echocardiography, and genetic testing in individuals without personal risk factors. The recommendations by ACPM address only mass screening approaches to detecting SCD and are not targeted toward individuals who may be identified by their healthcare provider as above average risk who may benefit from additional testing with the modalities mentioned above. ACPM supports the adoption of the National Heart, Lung, and Blood Institute (NHLBI) Working Group research agenda to evaluate the effectiveness of any screening program in reducing ...

Although epidemiological risk factors for sudden cardiac death (SCD) such as age, prior myocardial infarction and low ejection fraction are well established, the syndrome also has a strong genetic component. Identifying high-risk candidates and subsequent referral can significantly reduce the incidence of SCD among first-degree relatives.. ...

The incidence of sudden cardiac death in users of atypical anti-psychotics like clozapine, risperidone, quetiapine and olanzapine is almost twice that of individuals who do not take these drugs. Sudden cardiac death is a sudden pulseless condition that is fatal, precipitated by ventricular tachyarrhythmia in the absence of known non-cardiac cause. This risk of sudden cardiac death increases with increased dose of the anti-psychotic medications.. Of late atypical anti-psychotics are being increasingly prescribed and are replacing the older anti-psychotic drugs. The results were obtained from a retrospective cohort trail that involved 93,300 users of anti-psychotic medications and 18300 matched controls. It is useful to note that typical anti-psychotics like haloperidol and thioridazine can also cause increased incidence of sudden cardiac death. One of the explanations provided is that anti-psychotics through blockade of potassium channels increase the prolongation of the cardiac repolarization, ...

More than 80 percent of all cases of sudden cardiac death occur in people who have significant coronary artery disease, but we currently do not have a medical test that consistently identifies patients at risk, said Sumeet S. Chugh, M.D., associate director of the Cedars-Sinai Heart Institute and director of Clinical Electrophysiology. Chugh is first author of an article in Circulation, now appearing online ahead of print. This research was conducted with colleagues in the Emergency Medicine and Pathology Departments at Oregon Health and Science University in Portland, as part of the ongoing Oregon Sudden Unexpected Death Study. Abnormal QT prolongation has significant potential for evaluating risk and developing prevention strategies, but there are many factors - some known and some not known - that contribute to QT prolongation. Diabetes and the use of certain medications were significant predictors of QT interval prolongation and sudden cardiac death risk in our study. However, the most ...

Sudden Cardiac Death Aspartame MSG Heart disease. Sudden Cardiac Death and Food Excitotoxin Additives by Russell L. Blaylock, MD. 2009. http://web.mac.com. Over 460,000 people per year are now dying of a disorder called of sudden cardiac death according to CDC statistics. This is a condition striking otherwise healthy people, who have experienced no obvious symptoms of heart disease prior to their deaths. An alarming number of these deaths are occurring in young athletes, both in high schools, colleges, as well as among professional athletes.. While cardiologists have found coronary disease and suspect previous scars from silent heart attacks in a number of these individuals, one mechanism is getting no attention at all, and that is excitotoxic damage caused by food additives and the artificial sweetener aspartame. This is despite growing evidence that the excitotoxic mechanism plays a major role in cardiac disease.. Previously, it was thought that excitotoxin food additives, such as monosodium ...

This study included 267 SCA cases and 445 control subjects whose serum calcium levels were measured during routine medical care. All SCA cases had had serum calcium levels measured in the 90 days prior to their cardiac arrest.. The Oregon SUDS collaborates with emergency responders and hospitals in the Portland, OR metro area to identify all cases of sudden cardiac arrest. This enabled researchers to collect comprehensive patient medical history from the time prior to their cardiac arrest.. Each patient`s total serum calcium was corrected by their serum albumin level to estimate a more physiologically relevant corrected calcium level.SCA cases had a significantly higher percentage of African Americans and patients with diabetes mellitus, chronic obstructive pulmonary disease, and chronic kidney disease compared to the control group.. Cases were also more likely than controls to be on hemodialysis.In addition, diuretics, especially loop diuretics, were prescribed more for cases than for controls ...

TY - JOUR. T1 - Occupation and risk of sudden death in a United States community. T2 - A case-control analysis. AU - Zhang, Lin. AU - Narayanan, Kumar. AU - Suryadevara, Vallabh. AU - Teodorescu, Carmen. AU - Reinier, Kyndaron. AU - Uy-Evanado, Audrey. AU - Chugh, Harpriya. AU - Zheng, Zhi Jie. AU - Gunson, Karen. AU - Jui, Jonathan. AU - Chugh, Sumeet S.. PY - 2015. Y1 - 2015. N2 - Objective: Work environment is said to influence cardiovascular risk. We assessed whether nature of occupation affects risk of sudden cardiac death (SCD) in the general population. Methods: In the ongoing, prospective Oregon Sudden Unexpected Death Study (catchment population 1 million), working-age SCD cases (18-65 years) were compared with controls who died from any cause. Usual occupation obtained from death certificates was classified using the US Census Bureau standard occupational classification descriptions and categorised as white collar, blue collar or homemaker. Odds ratio (OR) for SCD by occupation ...

Evidence-based recommendations on subcutaneous implantable cardioverter defibrillator insertion for preventing sudden cardiac death

TY - CHAP. T1 - Non-steroidal anti-inflammatory drugs and increased risk of sudden cardiac death. AU - Hwang, Soyun M.. AU - Gilda, Jennifer E.. AU - Cui, Ziyou. AU - Gomes, Aldrin V. PY - 2013. Y1 - 2013. UR - http://www.scopus.com/inward/record.url?scp=84892089153&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84892089153&partnerID=8YFLogxK. M3 - Chapter. AN - SCOPUS:84892089153. SN - 9781626187863. SP - 123. EP - 167. BT - Sudden Cardiac Death: Epidemiology, Genetics and Predictive/Prevention Strategies. PB - Nova Science Publishers, Inc.. ER - ...

ABSTRACT: BACKGROUND: A variety of mutations in HERG, the major subunit of the rapidly activating component of the cardiac delayed rectifier I(Kr), have been found to underlie the congenital Long-QT syndrome, LQT2. LQT2 may give rise to severe arrhythmogenic phenotypes leading to sudden cardiac death. OBJECTIVE: We attempt to elucidate the mechanisms by which heterogeneous LQT2 genotypes can lead to prolongation of the action potential duration (APD) and consequently the QT interval on the ECG. METHODS: We develop Markovian models of wild-type (WT) and mutant I(Kr) channels and incorporate these models into a comprehensive model of the cardiac ventricular cell. RESULTS: Using this virtual transgenic cell model, we describe the effects of HERG mutations on the cardiac ventricular action potential (AP) and provide insight into the mechanism by which each defect results in a net loss of repolarizing current and prolongation of APD. CONCLUSIONS: This study demonstrates which mutations can prolong ...

While some published research has hinted at the connection between the sickle cell trait and sudden cardiac death among young, athletic African-American males, which was initially observed in black military recruits 25 years ...

The studies were analysed by the researchers from China, who compared patients treated with macrolides to similar patients treated with other antibiotic therapy, or with no antibiotics at all. The collected studies were conducted between 1966 and 2015.. The researchers found an average of 80 cases of ventricular tachyarrhythmias-rapid heartbeat that can lead to sudden cardiac death-per million treatment courses in patients who were not taking macrolides. The current use of macrolides accounted for an additional 118 ventricular tachyarrhythmias or related sudden cardiac deaths per million treatment courses; 36 additional sudden cardiac deaths from causes other than ventricular tachyarrhythmia; and 38 additional cardiovascular deaths per million treatment courses.. Past use of macrolides and use of other antibiotics were not associated with increased cardiovascular risk in the study. In addition, the use of macrolides was not associated with increased all-cause death, possibly because of the ...

There are few data regarding the incidence of ventricular arrhythmias beyond the immediate post-procedural period after ASA. In one series of 39 patients, programmed ventricular stimulation was performed before and 2 weeks after ASA; 60% of these patients had a repeat electrophysiology study at 7 months post-procedure as well (21). These investigators showed that there was actually a nonsignificant decrease in inducibility of VT/VF after the procedure. Additionally, the event-free survival in this group was 100% over a 15-month follow-up period. In a series of 50 patients who underwent ASA (21), 2 patients developed VF in the immediate post-procedure setting, but no patients developed sustained ventricular arrhythmias after 48 h out from their procedure. In another study, 9 patients who underwent ASA were followed up with serial Holter monitors at 3, 7, and 90 days after their intervention (23), and no ventricular arrhythmias were found with the exception of isolated premature ventricular ...

Hypertrophic Cardiomyopathy, Sudden Death, and Endocarditis. A small number of people with HCM have an increased risk of sudden cardiac death. People at risk include.: Those who have family members who have had sudden cardiac death. Young people with HCM who have had several episodes of fainting. Those who have an abnormal blood pressure response with exercise. Adults who have a history of arrhythmia with a fast heart rate. Those with severe symptoms and poor heart function. If you have two or more risk factors for sudden cardiac death, your doctor will treat you with medications to prevent arrhythmias or with an ICD. Most people with HCM are at low risk for sudden cardiac death. Talk to your doctor about any concerns you may have. How Can I Prevent Endocarditis? People with obstructive HCM may be at increased risk for infective endocarditis, a potentially life-threatening condition ...

Background: Renin-angiotensin system inhibition (RASI) is frequently avoided in aortic stenosis (AS) patients because of fear of hypotension. We evaluated if RASI with angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) increased mortality in patients with mild to moderate AS. Methods: All patients (n = 1873) from the Simvastatin and Ezetimibe in Aortic Stenosis study: asymptomatic patients with AS and preserved left ventricular (LV) ejection fraction were included. Risks of sudden cardiac death (SCD), cardiovascular death and all-cause mortality according to RASI treatment were analyzed by multivariable time-varying Cox models and propensity score matched analyses. Results: 769 (41%) patients received RASI. During a median follow-up of 4.3 +/- 0.9 years, 678 patients were categorized as having severe AS, 545 underwent aortic valve replacement, 40 SCDs, 103 cardiovascular and 205 all-cause deaths occurred. RASI was not associated with SCD (HR: 1.19 [95% CI: ...

Unfortunately, of all patients experiencing acute myocardial infarction (MI), usually in the form of ST-elevation MI, 25-35% will die of sudden cardiac death (SCD) before receiving medical attention, most often from ventricular fibrillation. For pati

Background- Sudden cardiac death among orthotopic heart transplant recipients is an important mechanism of death after cardiac transplantation. The role for implantable cardioverter-defibrillators (ICDs) in this population is not well established. This study sought to determine whether ICDs are effective in preventing Sudden cardiac death in high-risk heart transplant recipients.. Methods and Results- We retrospectively analyzed the records of all orthotopic heart transplant patients who had ICD implantation between January 1995 and December 2005 at 5 heart transplant centers. Thirty-six patients were considered high risk for sudden cardiac death. The mean age at orthotopic heart transplant was 44±14 years, the majority being male (n=29). The mean age at ICD implantation was 52±14 years, whereas the average time from orthotopic heart transplant to ICD implant was 8 years ±6 years. The main indications for ICD implantation were severe allograft vasculopathy (n=12), unexplained syncope (n=9), ...

BERLIN, GERMANY. Dr. Emanuel Severus of the Berlin University points out that major depression is characterized by a deficiency of omega-3 fatty acids and that these acids possess powerful antiarrhythmic properties. He suggests that the missing link in the recently established association between major depression and sudden cardiac death may be the omega-3 fatty acid deficiency which characterizes both conditions ...

Sudden death in a young person is a devastating event for any family. Unfortunately, in many cases this can be the first presentation of an underlying heart condition in an otherwise healthy person. A range of inherited heart conditions can cause sudden death and therefore it is important to investigate family members following such an event. Inherited heart conditions can be broadly grouped into causing one of two types of problems in the heart - electrical or structural. Electrical problems include long QT and Brugada syndromes, while structural problems include hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy.. When a person dies suddenly, a post-mortem (also known as an autopsy) is often performed to determine why they died. Some heart conditions are more easily diagnosed at post-mortem than others. In particular, structural causes of sudden death can be determined at post-mortem since the heart may be thickened, enlarged or structures within the heart, such as ...

Indiana University School of Medicine researchers have found that Omega-3 fatty acids may protect dialysis patients from sudden cardiac death.

CORRESPONDENCE. Sudden cardiac arrest in the young - a call to action. To the Editor: Sudden cardiac arrest (SCA) in athletes has once again been brought into the spotlight as a result of the recent widely publicised collapse and resuscitation of Fabrice Muambo during a FA Cup soccer match in the United Kingdom. The efforts of the trained medical responders in his successful resuscitation must be applauded. This incident resulted in the South African Premier Soccer League announcing more rigorous screening of players as a primary prevention measure. Sadly, Muambos case was followed by the sudden cardiac death of Olympic swimmer Alexander Dale Oen.. Electrocardiographic screening of athletes for cardiac abnormalities forms part of a sound primary prevention strategy.1 A major remaining challenge is the unpredictability of SCA in unscreened athletes, as only a minority will be screened. Another cause of SCA, commotion cordis, can occur when young athletes with structurally normal hearts sustain a ...

Bryan Heart is first in the region to treat patients who suffer from sudden cardiac arrest with an implantable cardioverter defibrillator (ICD).

Many people live for years with symptoms of heart failure. However, heart failure is a serious, progressive disease that can eventually cause or contribute to death. The symptoms of heart failure occur because the heart muscle has suffered damage and cant keep up with the bodys needs. The hearts enlargement and inability to pump tend to increase with time.. Also, heart failure patients can be more prone to abnormal heart rhythms, which increase the risk of sudden death. From 1993-2003, deaths from heart failure increased 20.5%3. People with heart failure usually die of either pump failure or sudden cardiac death.. Many heart failure deaths occur suddenly. You may have heard this problem described as cardiac arrest or sudden cardiac death (SCD).. What happens when someone has a sudden death event? The electrical impulses telling the heart to contract are sent too quickly through the heart muscle. The heartbeat becomes so rapid and chaotic that blood cannot move through the hearts chambers. ...

Routinely implanting pager-size defibrillators in heart attack survivors to stop cardiac arrest reduces their chance of dying by a surprising one-third and could benefit millions of Americans, a major study found.

Lets start with an analogy from the athletic pre-participation physical: Cardiovascular Screening. In order to reduce sudden cardiac death in athletes, current guidelines recommend that an athlete undergo 12 tests including: targeted questions of personal and family history, heart murmur, femoral pulses to exclude aortic coarctation, physical stigmata of Marfans syndrome, and brachial artery blood pressure (standard blood pressure reading).1 This screening protocol has a low sensitivity for detecting conditions related to sudden cardiac death, so there has been extensive discussion in the literature about adding 12 lead EKG to the screening protocol. The use of 12 lead EKG is under great debate because of its high false positive rate (between 15 and 40%), the associated medical costs, and the lack of qualified personnel to interpret the results. Whats interesting about this is that even with the addition of EKG, every cardiac condition predisposing young athletes to sudden cardiac death is ...

PMCMP : Sudden cardiac death (SCD) is estimated to occur at an incidence of between 50 to 100 per 100,000 individuals in North America and Europe each year, claiming between 250,000 and 450,000 lives in the United States annually. In younger individuals (ages 15-35), the incidence of SCD is between 1 to 2 per 100,000 young individuals. Sudden cardiac death, particularly in young individuals, may suggest an inherited form of heart disease. In some cases of sudden cardiac death, autopsy may identify a structural abnormality such as a form of cardiomyopathy. Postmortem diagnosis of a hereditary cardiomyopathy may assist in confirmation of the cause and manner of death, as well as risk assessment in living family members.   The cardiomyopathies are a group of disorders characterized by disease of the heart muscle. Cardiomyopathies are often caused by inherited, genetic, factors. When the identified structural or functional abnormality observed in a patient cannot be explained by acquired causes,

WEDNESDAY, June 20, 2018 (HealthDay News) -- Hidden drug overdoses account for nearly 1 in 7 sudden cardiac deaths, a new study contends.. Researchers looked at more than 900 people in San Francisco who died of an apparent out-of-hospital cardiac arrest.. Through autopsies and lab tests, they found that only 541 of those people (59 percent) actually met the criteria set by the World Health Organization for sudden cardiac death.. Of those cases, 13.5 percent (nearly 1 in 7) were due to a hidden overdose, with lethal levels of opioids found in 61 percent of them.. The study also found significant racial and gender differences. This highlights the importance of investigating apparent sudden cardiac death in women and different groups of people, according to the researchers from the University of California, San Francisco, and the City and County of San Francisco Office of the Chief Medical Examiner.. Our findings demonstrate the poor accuracy of our current, widely adopted definitions for sudden ...

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Although AIDS remained the leading cause of mortality, SCD was disproportionately represented in this urban HIV-infected cohort, accounting for 13% of all deaths and 86% of cardiac deaths, at a rate 4.5-fold higher than expected. Compared with AIDS deaths, SCDs occurred in older patients with better control of their HIV disease, as measured by CD4 count and viral load.. In the general population, most SCD is due to coronary artery disease (15). SCDs in this cohort reflect the age (mean 49 years) and sex distribution (93% male) of patients with HIV presenting with acute coronary syndromes (5), and prior MI was strongly associated with SCD. This study also replicates in the HIV population other risk factors associated with SCD: cardiomyopathy (16), heart failure (17), arrhythmias (18), hypertension (19), and hyperlipidemia (19).. Patients with SCD had modest immunodeficiency, with similar CD4 counts (median 312 cells/mm3) and viral loads (median 3.8 log copies/ml) as the full cohort (353 cells/mm3 ...

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially fatal cardiac arrhythmia in individuals with a structurally normal heart. The disorder is characterized by syncope, typically beginning in the first decade of life, which may be triggered by physical activity or intense emotion. In patients with CPVT, stress- induced release of catecholamines causes a dysfunction of calcium-ion channel in myocytes. The ion channel dysfunction induces ventricular arrhythmias, which can lead to syncope or sudden cardiac death. Spontaneous recovery from the arrhythmia is possible, but the ventricular tachycardia can progress to ventricular fibrillation and sudden death. The incidence of CPVT within the population is not precisely known, but is estimated to be 1:10,000. Symptoms include syncope, dizziness, arrhythmia, and sudden cardiac death. Diagnosis may prove difficult, due to normal echocardiogram and electrocardiogram at a resting state. Testing must be performed under ...

Sudden Cardiac Arrest is the condition in which the heart unexpectedly ceases to function. Often, this is because of irregular and rapid quivering of the hearts lower pumping chambers (ventricles) called ventricular fibrillation. When this occurs, blood stops flowing to the brain and other vital organs, causing loss of consciousness or seizure-like activity in seconds.. If not treated within minutes, SCA results in death. The normal rhythm of the heart can only be restored with defibrillation, an electrical shock that is safely delivered to the chest by an automated external defibrillator (AED).. Sudden Cardiac Arrest is frequently the outcome of an underlying heart condition. It can also occur secondary to other conditions such as impact to the chest, heat stroke, asthma, drowning, electrocution, allergic reaction, or medication.. Sudden Cardiac Arrest is indiscriminate as to age, race or gender and kills over 300,000 Americans each year. Victims of SCA may never experience any warning ...

INDIANAPOLIS -- An electrocardiogram with severe abnormalities may predict the risk of sudden death for patients with the most common form of adult muscular dystrophy, according to a multicenter study

Background- Pharmacological interventions for prevention of sudden arrhythmic death in patients with chronic heart failure remain limited. Accumulating evidence suggests increased ventricular expression of T-type Ca2+ channels contributes to the progression of heart failure. The ability of T-type Ca2+ channel blockade to prevent lethal arrhythmias associated with heart failure has never been tested, however.. Methods and Results- We compared the effects of efonidipine and mibefradil, dual T- and L-type Ca2+ channel blockers, with those of nitrendipine, a selective L-type Ca2+ channel blocker, on survival and arrhythmogenicity in a cardiac-specific, dominant-negative form of neuron-restrictive silencer factor transgenic mice (dnNRSF-Tg), which is a useful mouse model of dilated cardiomyopathy leading to sudden death. Efonidipine, but not nitrendipine, substantially improved survival among dnNRSF-Tg mice. Arrhythmogenicity was dramatically reduced in dnNRSF-Tg mice treated with efonidipine or ...

Dundalk FC leant support to Cardiac Risk in the Young (CRY) by wearing t-shirts highlighting the charity to help raise awareness of Sudden Cardiac...

The Sudden Cardiac Arrest Foundation is a Non-Profit organization dedicated toward increasing awareness about sudden cardiac arrest. Join the SCA Community for SCA News, participate in the discussion forum, community blogs, share advice and gain insight.

The Sudden Cardiac Arrest Foundation is a Non-Profit organization dedicated toward increasing awareness about sudden cardiac arrest. Join the SCA Community for SCA News, participate in the discussion forum, community blogs, share advice and gain insight.

What is sudden cardiac arrest? Though a heart attack occurs when circulation of blood is blocked, cardiac arrest is the result of electrical disturbances that cause the heart to suddenly stop beating. Sudden cardiac Protect: Add Any Anti-oxidant Serum To Your Skin And Allow To Soak In May Be Combined With Your Moisturizer. , More Aiden Jackson death is an electrical problem, where your hearts rhythm is rapid and irregular and your heart cant pump effectively, so you suddenly collapse, Goldberg said. As you might expect, a sudden, unexpected loss of heart function results in an equally sudden loss of breathing and consciousness. Survival is possible after sudden cardiac arrest, with treatment. Once again, CPR, a defibrillator or chest compressions could save someones life until emergency personnel arrive. One cause of sudden cardiac arrest is a heart attack. Sometimes, people who are having heart attack have a complication of sudden cardiac death if they dont get to the hospital soon enough, ...

Aim. Studying the effect of β-blocker bisoprolol (Concor, «Nycomed») on remodeling, diastolic filling of both ventricles, myocardial ectopic activity, and heart rhythm variability in patients with AH. Materials and methods. Forty-six patients with degree 1-2 AH were evaluated. EchoCG, Holter ECG monitoring and 24-hour BP monitoring were conducted. Results. In patients with AH, bisoprolol slowed progression of cardiovascular remodeling, normalized structural and geometric parameters of the heart and ventricular diastolic filling, reduced autonomic sympathetic tone and ectopic activity of the myocardium, and thereby reduced the risk of sudden arrhythmic death ...