Gemin 4兔多克隆抗体(ab70750)可与人样本反应并经WB, IP, IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Search for mouse SNPs represented in dbSNP by gene or genome region. Results include selected strains. Filter by dbSNP function class.
While conducting research for my current novel DEAD BURN, I realized that there are some very interesting forensic facts that may or may not be widely known to most people. I have physical notebooks and online file folders filled with information that I might use in upcoming stories. Basically, I like to have more information…
While conducting research for my current novel DEAD BURN, I realized that there are some very interesting forensic facts that may or may not be widely known to most people. I have physical notebooks and online file folders filled with information that I might use in upcoming stories. Basically, I like to have more information…
Gemin6 - mouse gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN306406G1|/strong|, Gemin6 gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.
Complete information for GEMIN5 gene (Protein Coding), Gem Nuclear Organelle Associated Protein 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for GEMIN8 gene (Protein Coding), Gem Nuclear Organelle Associated Protein 8, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Gemin3 may link the varied proteins with known connection to ALS, suggesting a common pathway in this disease and, possibly, a treatment for many patients.
Probable ATP Dependent RNA Helicase DDX58 (DEAD Box Protein 58 or RIG I Like Receptor 1 or Retinoic Acid Inducible Gene 1 Protein or DDX58 or EC 3.6.4.13) - Pipeline
Fingerprint Dive into the research topics of Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. Together they form a unique fingerprint. ...
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene ...
RefSeq Summary (NM_001164239): DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. This gene is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009 ...
2001 by the National Academy of Sciences. Contributed by John N. Abelson, December 4, 2000. We thank members of the Rees and Bjorkman labs at California Institute of Technology for their assistance, advice, and use of their equipment, as well as Thomas Earnest and coworkers at the advanced light source synchrotron of Lawrence Berkeley National Laboratory. This work was supported by National Institutes of Health Grant GM32637 (to J.N.A.). Data deposition: The atomic coordinates have been deposited in the Protein Data Bank, www.rcsb.org (PDB ID code 1HV8). The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact ...
Failure of the pancreatic β-cells to compensate for high insulin needs is central to the pathogenesis of T2D, and several studies have reported a significant decrease in β-cell mass in T2D (2,26). Chronic exposure to FFAs causes loss of functional β-cell mass (34,35) and may contribute to T2D. Saturated lipids are harmful to β-cells, and pronounced ER stress signaling (especially in the PERK pathway) has been proposed to mediate lipotoxic apoptosis (7-10,15). Execution of FFA-induced apoptosis occurs through the mitochondrial pathway, as indicated by cytochrome c release from the mitochondria after palmitate treatment (13,36,37), but it remained to be clarified how palmitate-induced ER stress crosstalks with the mitochondria to culminate in β-cell death. We have now answered this question, showing that palmitate transcriptionally induces the BH3-only proteins DP5 and PUMA through PERK-dependent ATF3 expression (Fig. 6G).. In the hierarchical model for Bax/Bak activation, the BH3-only ...
DDX58, 0.1 ml. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative R helicases which are implicated in a number of cellular processes involving R binding and alteration of R secondary structure.
Xenopus XVLG1 protein: a Xenopus DEAD box protein; homologous to Drosophila vasa; MW 78,238 Da; pI 5.54; amino acid sequence given in first source
Expression of GEMIN8 (FAM51A1, FLJ20514) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
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DDX49兔多克隆抗体(ab103465)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Gemin4 is a ubiquitously expressed multifunctional protein that is involved in U snRNP assembly, apoptosis, nuclear/cytoplasmic transportation, transcription, and RNAi pathways. Gemin4 is one of the core components of the Gemin-complex, which also contains survival motor neuron (SMN), the seven Gemin proteins (Gemin2-8), and Unrip. Mutations in the SMN1 gene cause the autosomal recessive disorder spinal muscular atrophy (SMA). Although the functions assigned to Gemin4 predominantly occur in the nucleus, the mechanisms that mediate the nuclear import of Gemin4 remain unclear. Here, using a novel panel of Gemin4 constructs we identify a canonical nuclear import sequence (NLS) in the N-terminus of Gemin4. The Gemin4 NLS is necessary and independently sufficient to mediate nuclear import of Gemin4. This is the first functional NLS identified within the SMN-Gemin complex.. ...
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of…
ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene. This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. GRCh38: Ensembl release 89: ENSG00000123136 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000005481 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes ...
Looking for online definition of DEAH box protein 15 in the Medical Dictionary? DEAH box protein 15 explanation free. What is DEAH box protein 15? Meaning of DEAH box protein 15 medical term. What does DEAH box protein 15 mean?
ATP-dependent RNA helicase p54, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD), DEAD box protein 6, EC 3.6.4.13, EC 3.6.1, FLJ36338, HLR2DEAD box-6, Oncogene RCK, probable ATP-dependent RNA helicase DDX6, ...
IMPAKT 2014 is designed for breast cancer researchers and clinicians who have a specific interest in translational research, new agents, molecular and functional diagnostics, biomarkers and cutting-edge research applications in the clinical setting.
The programme can also benefit scientists, medical oncologists, breast surgeons, pathologists, imaging specialists, radiation oncologists, and other professionals involved in breast cancer research.


Main themes
Patient-derived xenografts: dissecting the mechanisms of resistance to systemic therapiesLiquid biopsy: Monitoring tumour-derived cell-free DNA, miRNA,CTCs and exosomes in patients with breast cancerNanotechnology approaches for the treatment and diagnosis of breast cancerPathways for drug discovery and development: from next generation genomics to next generation therapiesNUMB3RS and mathematical modeling to map the subway of biological networksMetastatic dormancy: investigating early dissemination and tumour cell quiescence |
Interferon induced with helicase C domain 1 (IFIH1) protein is a member of a group of RNA helicases, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), known as DEAD box proteins. IFIH1 is also known as melanoma differentiation-associated protein 5 (MDA5), clinically amyopathic dermatomyositis autoantigen 140 kDa, helicase with 2 CARD domains (HLCD), helicard, murabutide down-regulated protein, RIG-I-like receptor 2 (RLR-2), CADM-140 autoantigen, RNA helicase-DEAD box protein 116 (RH116), DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, and IDDM19. IFIH1/MDA5 plays a major role in sensing viral infection and in the activation of a cascade of antiviral and inflammatory responses. IFIH1 gene expression is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Treatment with both these agents causes irreversible reprogramming of melanomas, while treatment with either agent alone only achieves reversible differentiation. Mutations in ...
Interferon induced with helicase C domain 1 (IFIH1) protein is a member of a group of RNA helicases, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), known as DEAD box proteins. IFIH1 is also known as melanoma differentiation-associated protein 5 (MDA5), clinically amyopathic dermatomyositis autoantigen 140 kDa, helicase with 2 CARD domains (HLCD), helicard, murabutide down-regulated protein, RIG-I-like receptor 2 (RLR-2), CADM-140 autoantigen, RNA helicase-DEAD box protein 116 (RH116), DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, and IDDM19. IFIH1/MDA5 plays a major role in sensing viral infection and in the activation of a cascade of antiviral and inflammatory responses. IFIH1 gene expression is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Treatment with both these agents causes irreversible reprogramming of melanomas, while treatment with either agent alone only achieves reversible differentiation. Mutations in ...
Dead Girls is the début novel by British science fiction author Richard Calder, and was first published in the UK in 1992 (HarperCollins) and 1995 in the US (St Martins Press). The novel is the first in Calders Dead trilogy, and is followed by the novels Dead Boys (novel) and Dead Things. The novel was written in 1990, soon after Richard Calder had taken up residence in Thailand. He was living in Nongkhai, a small town on the Mekong River, overlooking Laos. He was also making frequent trips to Bangkok. Nongkhai, Bangkok and London are the storys most important locales. Dead Girls is a science fiction novel set in the year 2071 telling the tale of a virus that turns pubescent girls into vampiric gynoid dolls called Lilim, and the doomed love affair between 15-year-old Ignatz Zwakh and a Lilim assassin called Primavera. The idea for the quantum clockwork Cartier dolls comes from the story of Coppellia, a mechanical doll in one of the Tales from Hoffmann. Richard Calder cites Jacques ...
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by ...
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Reaktivität: Rind (Kuh), Hund, Meerschweinchen and more. 54 verschiedene GEMIN4 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
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