Download VENTILATION-PERFUSION RATIO by profisy4CHRIST for physiology students University of Ilorin [Ventilation-perfusion ratio,Physiological Variation,Pathological Variation - 1107]

Looking for online definition of Perfusion lung scan in the Medical Dictionary? Perfusion lung scan explanation free. What is Perfusion lung scan? Meaning of Perfusion lung scan medical term. What does Perfusion lung scan mean?

Retrograde perfusion (retroperfusion) is an artificial method of providing blood supply to an organ by delivering oxygenated blood through the veins. It may be performed during surgery that interrupts the normal arterial supply of blood to that organ. For instance, when performing surgery that interrupts the cerebral arteries, a hose placed into the femoral artery and the superior vena cava can redirect blood up the internal jugular vein to supply the brain. This technique was pioneered by Oscar Langendorff, who perfused mamallian hearts ex vivo for research applications. Thus, it is often called Langendorff perfusion. Langendorff heart Perfusion Levy WJ, Levin SK, Bavaria JE (July 1995). "Cerebral oxygenation during retrograde perfusion". Ann. Thorac. Surg. 60 (1): 184-6. doi:10.1016/s0003-4975(94)01000-5. PMID 7598586. Bell, R., Mocanu, M. & Yellon, D. Retrograde heart perfusion: The Langendorff technique of isolated heart perfusion. Journal of Molecular and Cellular Cardiology 50, 940-950 ...

TY - JOUR. T1 - Intraoperative retrograde perfusion sphinterometry to evaluate efficacy of autologous vas deferens 6-branch suburethral sling to properly restore sphincteric apparatus during robotic assisted radical prostatectomy. AU - Cestari, Andrea. AU - Soranna, Davide. AU - Zanni, Giuseppe. AU - Zambon, Antonella. AU - Zanoni, Matteo. AU - Sangalli, Mattia. AU - Ghezzi, Massimo. AU - Fabbri, Fabio. AU - Sozzi, Francesco. AU - Dell'Acqua, Vincenzo. AU - Rigatti, Patrizio. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Objectives: To describe urodynamically the effect of the use of 6-branch autologous suburethral sling, made with absorbable sutures and vas deferens, to support bladder neck and urethra during Robotic Assisted Radical Prostatectomy (RALP), to improve early urinary continence recovery. Materials & Methods: Retrograde leak point pressure (RLPP) was intraoperatively evaluated, by means of retrograde perfusion sphinterometry (RPS), in 77 patients (mean age ± SD: 65.64±7.23 years, mean BMI ± ...

Cytoreduction followed by hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival in patients with peritoneal carcinomatosis of colorectal origin. Animal models are important in the evaluation of new treatment modalities. The purpose of this study was to devise an experimental setting which can be routinely used for the investigation of HIPEC in peritoneal carcinomatosis. A new peritoneal perfusion system in tumor bearing rats were tested. For this purpose CC531 colon carcinoma cells were implanted intraperitoneally in Wag/Rija rats. After 10 days of tumor growth the animals were randomized into three groups of six animals each: group 1: control (n = 6), group 2: HIPEC with mitomycin C in a concentration of 15 mg/m2 (n = 6), group III: mitomycin C i.p. as monotherapy in a concentration of 10 mg/m2 (n = 6). After 10 days, total tumor weight and the extent of tumor spread, as classified by the modified Peritoneal Cancer Index (PCI), were assessed by autopsy of the animals. No postoperative

Hyperthermic intraperitoneal chemotherapy or HIPEC is a very specialized procedure Fox Chase Cancer Center doctors are using to targeting some rare cancers.

Intravenous almitrine has been used successfully for short-term improvement of PaO2in patients with acute respiratory failure. [4,5] At low doses (,10 [micro sign]g [middle dot] kg-1[middle dot] min-1), intravenous almitrine alone improves intrapulmonary shunt. [1] Such improvement in PaO2has been attributed to an intrapulmonary blood flow redistribution from the poorly ventilated zones toward the normal zones. [5,6] Such redistribution has been related to a preferential pulmonary vascular contraction in hypoxic zones. The recent development of inhaled therapies, such as nitric oxide (NO) and prostacyclin, to manipulate the flow component of the ventilation-perfusion ratio prompted us and others [7-9] to combine these therapies with almitrine to optimize the PaO2of severely hypoxic patients. However, such improvement in the ratio of PaO2to the inspiratory fraction of oxygen (FIO(2)) might be "cosmetic," because most deaths after acute respiratory distress syndrome (ARDS) were related to multiple ...

Chronotropic doses of dobutamine have been shown to increase transmural WT, even in perfusion beds subtended by coronary stenoses that range from 30% to 80% in diameter (8). If the stenosis is more severe or if higher doses of dobutamine are used, WT becomes abnormal (2). Transmural myocardial blood flow responses, however, are different, with decreases in myocardial blood flow observed even in milder non-flow limiting stenoses (2). As the stenosis becomes more severe, a marked decrease in subendocardial blood flow has been observed (9-11), with a marked decrease in endocardial/epicardial flow ratios. In this study, RTMCE detected this decrease in endocardial to epicardial blood flow abnormality in 45 of the 55 patients with LAD stenoses ,50%.. Another pertinent pharmacologic property of dobutamine is its ability to recruit the subepicardial layers to thicken. The subendocardium is responsible for over 40% of WT under resting conditions (12,13), and thus resting WT might be abnormal even when ...

The effects on coronary blood flow of the endecapeptide Eledoisin have been studied in the anesthetized dog. Eledoisin increases coronary blood flow without increasing myocardial contractility and heart rate. Nitroglycerin and the polypeptide bradykinin increase coronary blood flow in the same way, but are markedly less active than Eledoisin. l-Epinephrine increases coronary blood flow, but at the same time produces a stimulating action on the myocardium.. ...

CASE REPORT: We present a case of low-grade appendiceal mucinous neoplasm with peritoneal dissemination, in which single-port laparoscopic approach of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy was completed through a 5.5-cm incision. A 35-year-old man with no medical illness underwent laparoscopic appendectomy for acute appendicitis 3 months earlier. Postoperative surgical pathology reported a low-grade appendiceal mucinous neoplasm with positive margin. After complete assessment and Tumor Board discussion, the patient was scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. A single gel port access was inserted through a 5.5-cm peri-umbilical incision. The Peritoneal Cancer Index score was 4, and the decision was made to proceed with partial cecectomy, omentectomy, peritonectomy, and hyperthermic intraperitoneal chemotherapy with the Sugarbaker mitomycin C-based regimen. Postoperative care was carried out following the Enhanced Recovery ...

TY - JOUR. T1 - An observational study of Donor Ex Vivo Lung Perfusion in UK lung transplantation: DEVELOP-UK. AU - Fisher, Andrew. AU - Andreasson, Anders. AU - Chrysos, Alexandros. AU - Lally, Joanne. AU - Mamasoula, Chrysovalanto. AU - Exley, Catherine. AU - Wilkinson, Jennifer. AU - Qian, Jessica. AU - Watson, Gillian. AU - Lewington, Oli. AU - Chadwick, Thomas. AU - McColl, Elaine. AU - Pearce, Mark. AU - Mann, Kay. AU - McMeekin, Nicola. AU - Vale, Luke. AU - Tsui, Steven. AU - Yonan, Nizar. AU - Simon, Andre. AU - Marczin, Nandor. AU - Mascaro, Jorge. AU - Dark, John. PY - 2016/11/1. Y1 - 2016/11/1. N2 - Background - Many patients awaiting lung transplantation die before a donor organ becomes available. Ex vivo lung perfusion (EVLP) allows initially unusable donor lungs to be assessed and reconditioned for clinical use. Objective - The objective of the Donor Ex Vivo Lung Perfusion in UK lung transplantation study was to evaluate the clinical effectiveness and cost-effectiveness of EVLP in ...

TY - JOUR. T1 - Pulsatile perfusion improves regional myocardial blood flow during and after hypothermic cardiopulmonary bypass in a neonatal piglet model. AU - Ündar, Akif. AU - Masai, Takafumi. AU - Yang, Shuang Qiang. AU - Eichstaedt, Harald C.. AU - McGarry, Mary Claire. AU - Vaughn, William K.. AU - Fraser, Charles D.. PY - 2002/1/1. Y1 - 2002/1/1. N2 - Pediatric myocardial related morbidity and mortality after cardiopulmonary bypass (CPB) are well documented, but the effects of pulsatile perfusion (PP) versus nonpulsatile perfusion (NPP) on myocardial blood flow during and after hypothermic CPB are unclear. After investigating the effects of PP versus NPP on myocardial flow during and after hypothermic CPB, we quantified PP and NPP pressure and flow waveforms in terms of the energy equivalent pressure (EEP) for direct comparison. Ten piglets underwent PP (n = 5) or NPP (n = 5). After initiation of CPB, all animals underwent 15 minutes of core cooling (25°C), 60 minutes of hypothermic CPB ...

This phase I/II trial studies the safety, best dose and effectiveness of targeted gene therapy combined with isolated limb infusion (ILI) of melphalan and dactinomycin for treating patients with advanced extremity melanoma that cannot be removed by surgery. Adding gene therapy to a standard chemotherapy regimen in the isolated limb may enhance anti-cancer effects by inducing a systemic immune response against the tumor cells ...

TY - JOUR. T1 - Randomized phase II study comparing docetaxel plus cisplatin, docetaxel plus carboplatin, and paclitaxel plus carboplatin in patients with advanced or recurrent endometrial carcinoma. T2 - A Japanese Gynecologic Oncology Group study (JGOG2041). AU - Nomura, H.. AU - Aoki, D.. AU - Takahashi, F.. AU - Katsumata, N.. AU - Watanabe, Y.. AU - Konishi, I.. AU - Jobo, T.. AU - Hatae, M.. AU - Hiura, M.. AU - Yaegashi, N.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/3. Y1 - 2011/3. N2 - Background: The purpose of this study is to assess the efficacy and safety of treatment with taxane plus platinum in combination therapies for advanced or recurrent endometrial carcinoma. Patients and methods: Patients with measurable disease derived from histologically confirmed stage III/IV or recurrent endometrial carcinoma were randomly assigned to receive docetaxel plus cisplatin (DP), docetaxel plus carboplatin (DC), or paclitaxel plus carboplatin (TC) every 3 ...

(13)N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease. (13)N-ammonia PET as a measurement of hindlimb perfusion in a mouse model of peripheral artery occlusive disease

Background: Coronary spastic angina (CSA) is characterized by transient vasoconstriction of epicardial coronary arteries leading to myocardial ischemia. There have been several studies of coronary microvascular function in patients with CSA, but it is not yet clear whether coronary microvascular function is impaired. We investigated this relationship in the present study.. Methods: Thirty-four patients with CSA (28 men, mean age 58 years) were enrolled. CSA was defined as ,90% narrowing of the epicardial coronary arteries on the angiogram during a spasm provocation test with ergotamine maleate, accompanied by characteristic chest pain and/or ST-segment deviation on ECG. Thirty-six patients with a negative spasm provocation test matched for age and gender were enrolled in the control group. Before the spasm provocation test, acetylcholine (ACh) at a low dose (3 μg/min) was infused into the left coronary ostium for 2 min. Coronary blood flow (CBF) was calculated from quantitative angiography and ...

TY - JOUR. T1 - A CLUE for better assessment of donor lungs. T2 - Novel technique in clinical ex vivo lung perfusion. AU - Ayyat, Kamal S.. AU - Okamoto, Toshihiro. AU - Niikawa, Hiromichi. AU - Sakanoue, Ichiro. AU - Dugar, Siddharth. AU - Latifi, Samir Q.. AU - Lebovitz, Daniel J.. AU - Moghekar, Ajit. AU - McCurry, Kenneth R.. N1 - Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2020/11. Y1 - 2020/11. N2 - BACKGROUND: The direCt Lung Ultrasound Evaluation (CLUE) technique was proven to be an accurate method for monitoring extravascular lung water in donor lungs during ex vivo lung perfusion (EVLP) in an experimental model. The aim of this study was to examine the application of CLUE in the clinical setting. METHODS: Lungs were evaluated using acellular EVLP protocol. Ultrasound images were obtained directly from the lung surface. Images were graded according to the percentage of B-lines seen on ultrasound. CLUE scores were calculated at the ...

Serotonin constricts coronary arteries with endothelial dysfunction, a common abnormality in cardiac transplant recipients. To assess whether endothelial dysfunction is associated with myocardial blood flow (MBF) abnormalities, 24 patients were studied 1 to 12 months after transplantation. Serotonin in increasing doses (1, 10, and 20 micrograms/min for 2.5 min each) was infused into the coronary circulation. Diameters were measured by quantitative angiography. Fourteen patients (group A) had a pronounced artery constriction (diameter reduction | 40%), while in 10 other patients (group B), such a constriction was never reached. No patient had evidence of rejection and all had angiographically normal coronary arteries. MBF was measured at rest and after intravenous dipyridamole with dynamic nitrogen-13 ammonia positron emission tomography (PET). The resting MBF was higher in group A than in group B (94 +/- 12 vs 74 +/- 15 ml/min/100 g of tissue; p | 0.05). During dipyridamole, MBF was not significantly

article{aaaf1de4-de34-469a-ad34-52c691970e90, abstract = {BACKGROUND: Treating pulmonary valve stenosis with balloon valvuloplasty (BV) is a good model to study the effect of right ventricular (RV) pressures on coronary flow. METHODS: Transthoracic Doppler echocardiography was used to register coronary flow in 10 age-matched healthy controls and 7 neonates before and 1 day after BV. RESULTS: Left ventricular fractional shortening and cardiac output increased significantly after BV. Right coronary artery diameter decreased from 1.2 +/- 0.2 to 1.1 +/- 0.1 mm (P < .02). Posterior descending coronary artery flow parameters decreased significantly, with blood flow decreasing from 8.4 to 5.7 +/- 1.9 mL/s (P < .003). RV end-diastolic pressure and RV systolic pressure explained almost totally the variation in coronary flow (r(2) = 0.87). CONCLUSIONS: RV end-diastolic pressure and RV systolic pressure determined coronary flow in neonates with critical pulmonary valve stenosis. Cardiac output and ...

NOTOC__ {{Pseudomyxoma peritonei}} {{CMG}}{{AE}}{{Nnasiri}}{{PSD}} {{SK}} PMP; jelly belly; colloid carcinoma; disseminated peritoneal adenomucinosis (DPAM); malignant appendiceal tumor; malignant large bowel cystadenocarcinoma; malignant large bowel peritoneal carcinomatosis; malignant large bowel tumor; mucinous cyst adenocarcinoma; mucinous cystadenoma; peritoneal carcinomatosis; peritoneal mucinous carcinomatosis (PMCA); pseudomyxoma ovarii ==[[Pseudomyxoma peritonei overview,Overview]]== ==[[Pseudomyxoma peritonei historical perspective,Historical Perspective]]== ==[[Pseudomyxoma peritonei pathophysiology,Pathophysiology]]== ==[[Pseudomyxoma peritonei causes,Causes]]== ==[[Pseudomyxoma peritonei differential diagnosis,Differentiating Pseudomyxoma peritonei from other Diseases]]== ==[[Pseudomyxoma peritonei epidemiology and demographics,Epidemiology and Demographics]]== ==[[Pseudomyxoma peritonei risk factors,Risk Factors]]== ==[[Pseudomyxoma peritonei natural history, complications and ...

Breast cancer is the leading cause of cancer in women in China. Preoperative chemotherapy for treatment of locally advanced breast cancer has become a standard therapy. Results from neoadjuvant trials have shown that pathological complete response (pCR) is an independent predictor of outcome. Paclitaxel was introduced into clinical practice in the early 1990s and has demonstrated good activity in the adjuvant and metastatic settings. Platinum complexes, like cisplatin and carboplatin, are active in a wide range of solid tumors. Paclitaxel combined with carboplatin has shown great activity in ovarian and nonsmall- cell lung cancer treatment. In addition, the overall response rate of paclitaxel plus carboplatin was between 53% and 62% in the first-line treatment of metastatic breast cancer. This study will evaluate the pCR rate of weekly paclitaxel plus carboplatin as preoperative treatment for breast cancer patients ...

TY - JOUR. T1 - Semi-quantitative ventilation/perfusion scintigraphy and single-photon emission tomography for evaluation of lung volume reduction surgery candidates. T2 - Description and prediction of clinical outcome. AU - Jamadar, David A.. AU - Kazerooni, Ella A.. AU - Martinez, Fernando J.. AU - Wahl, Richard L.. PY - 1999/7/29. Y1 - 1999/7/29. N2 - Ventilation/perfusion scans with single-photon emission tomography (SPET) were reviewed to determine their usefulness in the evaluation of lung volume reduction surgery (LVRS) candidates, and as a predictor of outcome after surgery. Fifty consecutive planar ventilation (99mTc-DTPA aerosol) and perfusion 99mTc-MAA) scans with perfusion SPET of patients evaluated for LVRS were retrospectively reviewed. Technical quality and the severity and extent of radiotracer defects in the upper and lower halves of the lungs were scored from visual inspection of planar scans and SPET data separately. An emphysema index (EI) (extent x severity) for the upper ...

AIM. To assess the functionality of congenital coronary artery fistulas (CAFs) using adenosine stress N-13-ammonia positron emission tomography computed tomography (PET-CT).. METHODS. Congenital CAFs were incidentally detected during coronary angiography (CAG) procedures in 11 adult patients (six males and five females) with a mean age of 64.3 years (range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas (origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG. Five patients underwent adenosine pharmacologic stress N-13-ammonia PET-CT to assess myocardial perfusion and the functional behavior of the fistula.. RESULTS. Eleven patients with 12 CAFs, 10 unilateral and one bilateral, originating from the left anterior descending coronary artery (n = 8), right coronary artery (n = 2) and circumflex (n = 2). All fistulas were of the vascular type, terminating into either the ...

Myocardial perfusion reserve (hyperemic divided by basal myocardial blood flow) describes vasodilator responsiveness of coronaryresistive vessels. The effect of aging and gender on myocardial perfusion reserve remains controversial. Methods: We studied 56 normal volunteers (21 women, 35 men; aged 50 +/- 20 yr, range 21-86 yr) with O-15-water PET to measure myocardial blood flow during basal and hyperemic stales with intravenous dipyridamole (0.56 mg/kg, n = 46) or adenosine (140 mu g/kg/min, n = 10). For comparative analysis, patients were grouped according to age: ,30 yr (n = 11), 30-49 yr (n = 18), 50-69 yr (n = 15) and greater than or equal to 70 yr (n = 12). Results: Overall, basal flow was 1.00 +/- 0.26 ml/min/g and hyperemic flow was 3.31 +/- 1.38 ml/min/g, resulting in a myocardial perfusion reserve of 3.38 +/- 1.35. There was an increase in basal flow with age (r = 0.45, p , 0.025), although hyperemic flow was only lower in patients greater than or equal to 70 yr, causing a significant ...

The American College of Cardiology/American Heart Association task force (ACC/AHA 2007 guidelines) has assigned Class I recommendation for oxygen use to correct arterial oxygen desaturation (Sao2 ,90%) and Class IIa recommendation for all patients with unstable angina/non-ST-segment elevation myocardial infarction and uncomplicated ST-segment elevation myocardial infarction within the first 6 h after presentation. The rationale for oxygen use is based on 2 assumptions: 1) that increasing arterial oxygen tension decreases the acute ischemic injury and the eventual infarct area (5,6); and 2) the observation that some patients with uncomplicated myocardial infarction have arterial hypoxemia due to fluid retention in the lungs and a ventilation-perfusion mismatch.. However, the evidence supporting these assumptions is limited. Moreover, we are not aware of any studies demonstrating that normoxic subjects undergoing percutaneous coronary intervention for acute myocardial infarction derive any benefit ...

125I brachytherapy of locally advanced non-small-cell lung cancer after one cycle of first-line chemotherapy：a comparison with best supportive care Jingjing Song* Xiaoxi Fan* Zhongwei Zhao* Minjiang Chen* Weiqian Chen, Fazong Wu, Dengke Zhang, Li Chen, Jianfei Tu, Jiansong Ji Department of Interventional Radiology, Zhejiang University Lishui Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, People's Republic of China *These authors have contributed equally to this work Objectives: The objective of this study was to assess the efficacy of computed tomography (CT)-guided 125I brachytherapy alone in improving the survival and quality of life of patients with unresectable locally advanced non-small-cell lung cancer (NSCLC) after one cycle of first-line chemotherapy.Patients and methods: Sixteen patients with locally advanced NSCLC were treated with CT-guided 125I brachytherapy after one cycle of first-line chemotherapy (group A). Sixteen

PURPOSE To evaluate the role of early intensification with high-dose therapy (HDT) and autologous stem-cell transplantation (ASCT) as front-line chemotherapy for patients with high-risk, histologically aggressive non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS We planned a multicenter, randomized trial to compare a conventional chemotherapy regimen of methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B; arm A) with an abbreviated regimen of MACOP-B (8 weeks) followed by HDT and ASCT (arm B) for intermediate-high-risk/high-risk patients (according to the age-adjusted International Prognostic Index). From September 1994 to April 1998, 150 patients with aggressive lymphoma were enrolled onto the trial. Seventy-five patients were randomly assigned to arm A and 75 patients were randomly assigned to arm B. In both arms, involved-field radiation therapy (36 Gy) was delivered to the site of bulky disease. RESULTS The rate of complete

The shortage of donor organs for liver transplantation requires investigations into expanding the donor pool. Non-heart beating donor (NHBD) livers are an untapped source of organs. NHBD organs are those that have had a period of warm ischemia prior to cold preservation. A main concern of NHBD livers is that there is a depletion of energy stores during the warm ischemia and subsequent cold storage. This study is to investigate the use of hypothermic machine perfusion to regenerate energy stores in the liver during 5hr storage and after 1hr rewarming in a rat transplantation model. Results will be compared with control. (no warm ischemia) and simple cold stored tissues.. Copyright © 2003 by ASME ...

TY - JOUR. T1 - Phase 1 Study of Accelerated Hypofractionated Radiation Therapy With Concurrent Chemotherapy for Stage III Non-Small Cell Lung Cancer. T2 - CALGB 31102 (Alliance). AU - Urbanic, James J.. AU - Wang, Xiaofei. AU - Bogart, Jeffrey A.. AU - Stinchcombe, Thomas E.. AU - Hodgson, Lydia. AU - Schild, Steven E.. AU - Bazhenova, Lyudmila. AU - Hahn, Olwen. AU - Salgia, Ravi. AU - Vokes, Everett E.. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Purpose: To investigate the safety of accelerated hypofractionated radiation therapy (AHRT) with concurrent chemotherapy (CT) for inoperable stage III non-small cell lung cancer (NSCLC). Patients and Methods: The primary objectives were to define the maximally tolerable course of accelerated radiation therapy and to describe toxicities of therapy. Total radiation therapy remained at 60 Gy. The number of once-daily fractions in each successive cohort was reduced as follows: cohort 1, 60 Gy in 27 fractions; cohort 2, 60 Gy in 24 fractions; cohort 3, 60 Gy in 22 ...

A study to evaluate the efficacy of lenalidomide as maintenance therapy after completion of first-line combination chemotherapy in patients with mantle cell lymphoma (MCL) who are not candidates for transplantation and have achieved partial response (PR) or complete response (CR).. This study was prematurely terminated by the sponsor in light of new unpublished data that rendered the current design of the study no longer clinically relevant. A study design with the control arm of no active treatment was no longer appropriate. The termination of the trial was not based on any safety concerns in the study. ...

TY - JOUR. T1 - Limited-stage small-cell lung cancer. T2 - Patterns of intrathoracic recurrence and the implications for thoracic radiotherapy. AU - Liengswangwong, V.. AU - Bonner, J. A.. AU - Shaw, E. G.. AU - Foote, R. L.. AU - Frytak, S.. AU - Eagan, R. T.. AU - Jett, J. R.. AU - Richardson, R. L.. AU - Creagan, E. T.. AU - Su, J. Q.. PY - 1994/3. Y1 - 1994/3. N2 - Purpose: This analysis was performed to determine the most appropriate volume that should be encompassed by thoracic radiation treatments (TRTs) for patients with limited-stage small-cell lung cancer (LSSCLC) who have responded to initial chemotherapy. Patients and Methods: A retrospective review of all patients (N = 67) with LSSCLC who were not entered onto a research protocol and were treated at our institution between the years of 1982 and 1990 was performed. Fifty-nine of 67 patients had adequate information regarding the size of the tumor before the start of chemotherapy (computed tomographic [CT] scan of chest or chest ...

Background and Objectives: Extensive surgery is often required for advanced soft tissue sarcoma (STS) of the limb. In the 1980s, a new approach was developed: isolated limb perfusion (ILP). This study aimed to assess incidence and impact on patient survival based on lymph node metastasis with systematic radical lymphadenectomy during ILP.. Methods: Retrospective study of 57 consecutive patients treated by ILP for limb STS with simultaneous radical lymph node dissection in our tertiary referral center between 1992 and 2015.. Results: Median age was 62 years (19-87) and 30 patients were male (53%). Lymph node involvement was observed in 13 patients (N1, 23%), regarded as metastatic spreading in 4 angiosarcomas, 3 epithelioid sarcomas, 2 leiomyosarcomas, 2 undifferentiated sarcomas and 2 synovial sarcomas. For the N0 patient group, median survival was 73.9 months (CI 95% 41.9-105.9) compared to 15.1 months (CI 95% 7.4-22.6) in case of metastatic lymph node (p=0.002). The median disease-free ...

TY - JOUR. T1 - Extremity sarcomas. T2 - An analysis of prognostic factors from the intergroup rhabdomyosarcoma study III. AU - Andrassy, Richard J.. AU - Corpron, Cynthia A.. AU - Hays, Daniel. AU - Raney, R. Beverly. AU - Wiener, Eugene S.. AU - Lawrence, Walter. AU - Lobe, Thom E.. AU - Bagwell, Charles. AU - Maurer, Harold M.. PY - 1996/1. Y1 - 1996/1. N2 - Purpose: Prognostic factors for extremity sarcomas have been reported previously, after analysis of Intergroup Rhabdomyosarcoma Studies (IRS) I and II. This report reviews the experience of IRS III (1984-1992), in light of these reported factors, and the pretreatment factors used in the staging system currently being evaluated in IRS IV. The results of treatment of extremity sarcomas in IRS III are reported. Methods: The charts of all patients entered in IRS III with an extremity-site tumor were reviewed. This group included patients with shoulder girdle and buttock sites. All patients were treated according to IRS III protocols. Survival ...

Splenectomy during cytoreductive surgery in epithelial ovarian cancer Hengzi Sun,1 Xiaoning Bi,1 Dongyan Cao,1 Jiaxin Yang,1 Ming Wu,1 Lingya Pan,1 Huifang Huang,1 Ge Chen,2 Keng Shen1 1Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; 2Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Background: The aim of the study was to analyze the underlying causes and application of splenectomy in patients with epithelial ovarian cancer (EOC) and assess its effect on the surgical satisfaction and prognosis of these patients.Materials and methods: Clinical data of patients with ovarian epithelial cancer treated with cytoreductive surgery were collected from 2000 to 2015 at Peking Union Medical College Hospital.Results: A total of 2,882 patients underwent ovarian cancer cytoreductive surgery at

TY - CHAP. T1 - Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion. AU - Heller, Charles K.. AU - Pingpank, James F.. AU - Libutti, Steven K.. PY - 2009/12/9. Y1 - 2009/12/9. KW - Hepatic arterial infusion (HAI). KW - Inferior vena cava (IVC). KW - Isolated hepatic perfusion and percutaneous hepatic perfusion. KW - Metastatic neuroendocrine tumors (MNET). KW - National institutes of health (NIH). KW - Percutaneous hepatic perfusion. KW - Tumor necrosis factor (TNF). KW - Veno-occlusive disease (VOD). UR - http://www.scopus.com/inward/record.url?scp=84948987546&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84948987546&partnerID=8YFLogxK. U2 - 10.1002/9781444317053.ch15. DO - 10.1002/9781444317053.ch15. M3 - Chapter. AN - SCOPUS:84948987546. SN - 9781444317053. SN - 9781405179768. SP - 164. EP - 172. BT - Malignant Liver Tumors: Current and Emerging Therapies: Third Edition. PB - Wiley Blackwell. ER - ...

Benign peritoneal cystic mesothelioma is a rare disease of the abdominal cavity with grape - like cystic lesions, solitary or disseminated. The etiology is unclear, with a neoplastic or reactive origin being the prominent considerations. Because of its high recurrence rate and occasional malignant transformation, radical surgical approaches with optional hyperthermic intraperitoneal Chemotherapy have increasingly been advocated with mixed results. We present a case report with a new conservative approach using the Cavitron ultrasonic surgical aspirator for the first time in benign cystic mesothelioma of the peritoneum and a review of the literature about the treatment of this condition. A 47-year-old female with a history of abdominal surgery, including endometriosis excision and hysterectomy presented with upper abdominal discomfort. Ultrasound and magnetic resonance imaging showed two peritoneal tumors with multiple thin-layered cysts. Exploratory laparoscopy revealed multiple cystic masses. Biopsies

Looking for online definition of Lung Perfusion Scan in the Medical Dictionary? Lung Perfusion Scan explanation free. What is Lung Perfusion Scan? Meaning of Lung Perfusion Scan medical term. What does Lung Perfusion Scan mean?

Continuous hypothermic pulsatile perfusion (CHPP) may offer improved early function compared with cold static perfusion (CSP) for heart-beating cadaveric donors. With an expanding pool of donors, ie, non-heart-beating donors (NHBD), we present our preliminary results with the use of CHPP compared with CSP to preserve kidney grafts retrieved from NHBD. Eighteen consecutive locally procured cadaveric kidneys from NHBD were preserved using CHPP using UW machine perfusion solution in the Life Port kidney transporter. Perfusion parameters were measured serially during pulsatile perfusion. This group was compared with 18 NHBD cadaveric kidneys preserved with CSP. No organs were lost due to faulty technique of preparation or preparation of pulsatile perfusion. Immediate renal function was observed in 13 cases (72.2%). In CSP in NHBD, we had 16 cases with delayed graft function (88.8%). These early results show that the use of pulsatile perfusion to preserve kidneys from NHBD may be associated with improved

METHODS AND RESULTS Eighteen dogs were instrumented with regional myocardial function sonomicrometers in the ischemic and control zones. The left anterior descending coronary artery just distal to the first diagonal branch was instrumented with a silk snare and Doppler flow probe. Additionally, pressure catheters were placed in the left atrial appendage, left ventricular apex, and ascending aorta for hemodynamic measurements. Regional myocardial blood flow was determined by using 15-microns radioactive microspheres. Measurements were made in the control state, immediately after coronary occlusion, at 1 and 2 hours after coronary occlusion, with reperfusion, and 1 hour after reperfusion. In treated animals, left ventricular assistance was maintained during the entire period of occlusion and reperfusion. The Hemopump was associated with a significant decrease in left ventricular systolic and diastolic pressure, whereas mean arterial pressure was maintained. Intra-aortic balloon counterpulsation ...

Adipose tissue engineering holds promise to address the unmet need in plastic and reconstructive surgery for strategies that promote the stable and predictable regeneration of adipose tissue for volume augmentation applications. Previous studies have demonstrated that decellularized adipose tissue (DAT) scaffolds can provide a pro-adipogenic microenvironment, and that seeding with adipose-derived stromal cells (ASCs) can enhance in vivo angiogenesis and adipogenesis within DAT implants. Recognizing that bioreactor systems can promote cell expansion and infiltration on tissue-engineered scaffolds, this study evaluated the effects of culturing human ASCs on DAT scaffolds within a perfusion bioreactor. Using this system, the impact of both shear stress stimulation and hypoxic preconditioning were explored in vitro and in vivo. Initial studies compared the effects of 14 days of culture within the perfusion bioreactor under 2% O2 or ~20% O2 on human ASC expansion and hypoxic inducible factor 1 alpha ...

Background: Endoscopic lung volume reduction (ELVR) therapy using one-way valves is used to treat chronic obstructive pulmonary disease patients with severe heterogeneous emphysema. A successful treatment results in atelectasis of the treated pulmonary lobe with subsequent reduction of ventilation (V) and perfusion (Q). Objective: We evaluated the effects of ELVR on the targeted lobe using a new 3-dimensional ventilation and perfusion (V/Q) single-photon emission computed tomography (SPECT)/computed tomography (CT) analysis, which allows for simultaneous semi-automatic lobar pulmonary quantification of volume, ventilation and perfusion, on the first consecutive patients treated with ELVR at Rigshospitalet, Denmark. V/Q planar scintigraphy and V/Q SPECT/CT and lung function measurements were performed before and 6 months after intervention. Results: We included 24 subjects (60 years, range 46-74 years; 37.5% men) with a baseline FEV1 of 25% predicted and RV of 257% predicted. V/Q ...

An inert gas is a gas which does not undergo chemical reactions under a set of given conditions. The noble gases often do not react with many substances, and were historically referred to as the inert gases. Inert gases are used generally to avoid unwanted chemical reactions degrading a sample. These undesirable chemical reactions are often oxidation and hydrolysis reactions with the oxygen and moisture in air. The term inert gas is context-dependent because several of the noble gases can be made to react under certain conditions. Purified argon and nitrogen gases are most commonly used as inert gases due to their high natural abundance (78% N2, 1% Ar in air) and low relative cost. Unlike noble gases, an inert gas is not necessarily elemental and is often a compound gas. Like the noble gases the tendency for non-reactivity is due to the valence, the outermost electron shell, being complete in all the inert gases. This is a tendency, not a rule, as noble gases and other "inert" gases can react to ...

TY - JOUR. T1 - Noninvasive quantification of airway inflammation following segmental allergen challenge with functional MR imaging. T2 - A proof of concept study. AU - Renne, Julius. AU - Hinrichs, Jan. AU - Schönfeld, Christian. AU - Gutberlet, Marcel. AU - Winkler, Carla. AU - Faulenbach, Cornelia. AU - Jakob, Peter. AU - Schaumann, Frank. AU - Krug, Norbert. AU - Wacker, Frank. AU - Hohlfeld, Jens M.. AU - Vogel-Claussen, Jens. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Purpose: To evaluate oxygen-enhanced T1-mapping magnetic resonance (MR) imaging as a noninvasive method for visualization and quantification of regional inflammation after segmental allergen challenge in asthmatic patients compared with control subjects.Materials and After institutional review board approval, nine asthmatic Methods: and four healthy individuals gave written informed consent. MR imaging (1.5 T) was performed by using an inversion-recovery snapshot fast low-angle shot sequence before (0 hours) and 6 hours and 24 hours ...

article{Mateo:2014ch, author = {Mateo, J and Izquierdo-Garcia, D and Badimon, J J and Fayad, Z A and Fuster, V}, title = {{Noninvasive Assessment of Hypoxia in Rabbit Advanced Atherosclerosis Using 18F-fluoromisonidazole Positron Emission Tomographic Imaging}}, journal = {Circulation: Cardiovascular Imaging}, year = {2014}, volume = {7}, number = {2}, pages = {312--320}, month = mar, doi = {10.1161/CIRCIMAGING.113.001084}, pmid = {24508668}, pmcid = {PMC4083834}, language = {English}, read = {Yes}, rating = {0}, date-added = {2014-03-04T14:28:54GMT}, date-modified = {2020-09-17T14:01:10GMT}, abstract = {BACKGROUND: -Hypoxia is an important microenvironmental factor influencing atherosclerosis progression by inducing foam-cell formation, metabolic adaptation of infiltrated macrophages and plaque neovascularization. Therefore, imaging plaque hypoxia could serve as a marker of lesions at risk. METHODS AND RESULTS: -Advanced aortic atherosclerosis was induced in 18 rabbits by atherogenic diet and ...

Inert gas is produced on board crude oil carriers (above 8,000 tonnes)(from Jan 1, 2016) by using either a flue gas system or by burning kerosene in a dedicated inert gas generator. The inert gas system is used to prevent the atmosphere in cargo tanks or bunkers from coming into the explosive range.[6] Inert gases keep the oxygen content of the tank atmosphere below 5% (on crude carriers, less for product carriers and gas tankers), thus making any air/hydrocarbon gas mixture in the tank too rich (too high a fuel to oxygen ratio) to ignite. Inert gases are most important during discharging and during the ballast voyage when more hydrocarbon vapor is likely to be present in the tank atmosphere. Inert gas can also be used to purge the tank of the volatile atmosphere in preparation for gas freeing - replacing the atmosphere with breathable air - or vice versa. The flue gas system uses the boiler exhaust as its source, so it is important that the fuel/air ratio in the boiler burners is properly ...

The Cove Point Foundation Congenital Heart Resource Center is the world's largest resource for information on pediatric and adult congenital heart disease. Cove Point contains comprehensive information on all congenital heart defects, including Atrial Septal Defect (ASD), Ventricular Septal Defect (VSD), Hypoplastic Left Heart Syndrome (HLHS), and Tetralogy of Fallot (ToF). Cove Point also includes adult congenital heart disease information on exercise and pregnancy concerns as well as pediatric information on general nutritional and health issues for patients with congenital heart disease.

We discuss the case of a patient with PAH of multiple etiologies, and report to the best of our knowledge the first case of APS and factor V deficiency associated with MMM.. The etiology of PAH in this case was not that of emphysema or interstitial lung disease as evidenced by minimal parenchymal involvement on imaging studies. However, negative perfusion lung scan and doppler ultrasound of lower extremities could not exclude the possibility of pulmonary microthrombosis (6,8). Thrombotic microangiopathy has been associated with APS (10,26), and MPD (8,18). In fact, recurrent pulmonary embolism is assumed to be the major cause of PAH in APS (5,10); and, thromboembolism secondary to thrombophilia (in MMM) is well described (7,8,18).. Although titers of aPL were not available in our patient, the diagnosis of APS was satisfied by other major criteria. These major criteria were past episodes of vascular thrombosis (microangiopathic hemolytic anemia, myocardial infarction, and stroke), laboratory ...

Adenosine cardiovascular magnetic resonance (CMR) can accurately quantify myocardial perfusion reserve. While regadenoson is increasingly employed due to ease of use, imaging protocols have not been standardized. We sought to determine the optimal regadenoson CMR protocol for quantifying myocardial perfusion reserve index (MPRi) - more specifically, whether regadenoson stress imaging should be performed before or after rest imaging. Twenty healthy subjects underwent CMR perfusion imaging during resting conditions, during regadenoson-induced hyperemia (0.4 mg), and after 15 min of recovery. In 10/20 subjects, recovery was facilitated with aminophylline (125 mg). Myocardial time-intensity curves were used to obtain left ventricular cavity-normalized myocardial up-slopes. MPRi was calculated in two different ways: as the up-slope ratio of stress to rest (MPRi-rest), and the up-slope ratio of stress to recovery (MPRi-recov). In all 20 subjects, MPRi-rest was 1.78 ± 0.60. Recovery up-slope did not return to

The procedure of diagnosing peritoneal mesothelioma is like that of different sorts. It begins with a careful examination of your medicinal history, word related history, and general physical condition, trailed by a progression of tests including imaging sweeps and biopsies.. Make sure to say any history of asbestos presentation, regardless of the fact that your specialists neglect to inquire. It's essential to share everything about can incorporated, the dates the episodes happened and the length and span of the exposures. This data will caution your specialists about the likelihood of an asbestos-related sickness and offer them some assistance with determining the suitable next steps.. Since this growth is so uncommon, specialists who need involvement with the ailment frequently misdiagnose mesothelioma patients with more regular diseases who have comparative side effects - a genuine error that defers legitimate treatment. Peritoneal mesothelioma manifestations like stomach swelling, weight ...

The heart failure (HF) epidemic continues to rise with coronary artery disease (CAD) as one of its main causes. Novel concepts for risk stratification to guide the referring cardiologist towards revascularization procedures are of significant value. Myocardial perfusion imaging (MPI) using single-photon emission computed tomography (SPECT) agents has demonstrated high accuracy for the detection of clinically relevant stenoses. With positron emission tomography (PET) becoming more widely available, mainly due to its diagnostic performance in oncology, perfusion imaging with that modality is more practical than in the past and overcomes existing limitations of SPECT MPI. Advantages of PET include more reliable quantification of absolute myocardial blood flow, the routine use of computed tomography for attenuation correction, a higher spatiotemporal resolution and a higher count sensitivity. Current PET radiotracers such as rubidium-82 (half-life, 76 sec), oxygen-15 water (2 min) or nitrogen-13 ammonia (10