Biological sex plays a prominent role in the prevalence and severity of a number of important stress-related gastrointestinal and immune-related diseases including IBS and allergy/anaphylaxis. Despite the establishment of sex differences in these diseases, the underlying mechanisms contributing to sex differences remain poorly understood. The objective of this study was to define the role of biological sex on mast cells (MCs), an innate immune cell central to the pathophysiology of many GI and allergic disorders. Twelve-week-old C57BL/6 male and female mice were exposed to immunological stress (2 h of IgE-mediated passive systemic anaphylaxis (PSA)) or psychological stress (1 h of restraint stress (RS)) and temperature, clinical scores, serum histamine, and intestinal permeability (for RS) were measured. Primary bone marrow-derived MCs (BMMCs) were harvested from male and female mice and analyzed for MC degranulation, signaling pathways, mediator content, and RNA transcriptome analysis. Sexually
Background: Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and is one of the leading causes of cancer-related mortality across the globe. Majority of the NSCLC are characterized by the presence of ras mutation thereby rendering the subject relatively insensitive to treatment by known kinase inhibitors. Current treatment regimes for NSCLC are therefore limited to cytotoxic drugs besides surgery and radiation therapy. Herein, we describe the pharmacological profile of RP3035, a novel and potent cytostatic agent that inhibits tumor growth in xenograft models via a Calcium Release Activated Calcium (CRAC) channel pathway.. Methods: Inhibition of thapsigargin induced calcium influx into Fluo-8 loaded NCI-H460 cells was determined fluorometrically. Viability assay (MTT) was conducted to determine the growth inhibitory effect of the compound on NCI-H460, a NSCLC cell line. Lactate dehydrogenase (LDH) release into the medium was determined colorimetrically. In vivo efficacy ...
Glioblastoma (GBM) is the most common and most aggressive malignant primary brain tumor in adults. In spite of multimodal therapy concepts, consisting of surgery, radiotherapy and chemotherapy, the median survival, merely 15-18 months, is still poor. Mechanisms for resistance of GBM to radio(chemo)therapy are not fully understood yet and due to the genetic heterogeneity within the tumor including radiation-resistant tumor stem cells, there are several factors leading to therapy failure. Recent research revealed that, hypoxia during radiation and miRNAs may adversely affect the therapeutic response to radiotherapy. Further molecular alterations and prognostic markers like the DNA-repair protein O6-methylguanine-DNA methyltransferase (MGMT), anti-apoptotic molecular chaperones, and/or the activity of aldehyde dehydrogenase 1 (ALDH1) have also been identified to play a role in the sensitivity to cytostatic agents. Latest approaches in the field of radiotherapy to use particle irradiation or dose escalation
Resistance to cytostatic agents is a major clinical problem. The involvement of multidrug transporters like P-gp and MRP1 in development of resistance is well documented in vitro (1 , 2) . Recently, BCRP/MXR/ABCP, another member of the ABC family of transporter proteins, has been reported to be important in the development of resistance. It was overexpressed in a number of cell lines, which were selected by exposure to the topo II inhibitor MX (6) . The MX3 cell line described in this report was also developed using MX exposure. Cross-resistance to TPT in MX-selected BCRP/MXR/ABCP-overexpressing cell lines has been reported (6 , 9) . However, in this report, we demonstrate that BCRP/MXR/ABCP overexpression and related resistance can also be caused directly by exposure of tumor cells to TPT, as in the TPT-exposed T8 cell line, pronounced overexpression of BCRP/MXR/ABCP was observed.. The T8 and MX3 cell lines display a similar pattern of resistance, i.e., to topo I inhibitors TPT, SN-38, and ...
BACKGROUND AND PURPOSE Antiviral hyper-activation-limiting therapeutic agents (AV-HALTs) are a novel experimental drug class designed to both decrease viral replication and down-regulate excessive immune system activation for the treatment of chronic infections, including human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome. VS411, a first-in-class AV-HALT, is a single-dosage form combining didanosine (ddI, 400 mg), an antiviral (AV), and hydroxyurea (HU, 600 mg), a cytostatic agent, designed to provide a slow release of ddI to reduce its maximal plasma concentration (C(max)) to potentially reduce toxicity while maintaining total daily exposure (AUC) and the AV activity. EXPERIMENTAL APPROACH This was a pilot phase I, open-label, randomized, single-dose, four-way crossover trial to investigate the fasted and non-fasted residual variance of AUC, C(max) and the oral bioavailability of ddI and HU, co-formulated as VS411, and administered as two different fixed-dose combination
Literature References: Oxazaphosphine cytostatic agent; supresses B-cell activity and antibody formation. Prepn: H. Arnold, F. Bourseaux, Angew. Chem. 70, 539 (1958). Optical resolution study: T. Kawashima et al., J. Org. Chem. 43, 1111 (1978). Toxicology: A. G. Wheeler et al., Toxicol. Appl. Pharmacol. 4, 324 (1962). Book: D. L. Hill, A Review of Cyclophosphamide (Charles C Thomas, Springfield, 1975) 340 pp. Reviews of carcinogenicity studies: IARC Monographs 9, 135-156 (1975); of field trials as defleecing agent for sheep: M. H. Fahmy, Y. Moride, Anim. Breed. Abstr. 52, 7-19 (1984); of clinical toxicology: L. H. Fraiser et al., Drugs 42, 781-795 (1991); of mechanism of action and clinical use: O. M. Colvin, Curr. Pharmaceut. Design 5, 555-560 (1999); of analytical methods: M. Malet-Martino et al., ibid. 561-586; and metabolism: F. Baumann, R. Preiss, J. Chromatogr. B 764, 173-192 (2001). ...
Determining the antiplasmodial activity of candidate antimalarial drugs in vitro identifies new therapies for drug‐resistant malaria
Enzymatic conversion of most xenobiotic compounds is accomplished by hepatocytes in the liver, which are also an important target for the manifestation of the toxic effects of foreign compounds. Most cell lines derived from hepatocytes lack important toxifying or detoxifying enzymes or are defective in signaling pathways which regulate expression and activity of these enzymes. On the other hand, the use of primary human hepatocytes is complicated by scarce availability of cells and high inter-donor variability. Thus, analyses of drug metabolism and hepatotoxicity in vitro are a difficult task. The cell line HC-AFW1 was isolated from a pediatric hepatocellular carcinoma and so far has been used for tumorigenicity and chemotherapy resistance studies. Here, a comprehensive characterization of xenobiotic metabolism in HC-AFW1 cells is presented along with studies on the functionality of the most important transcriptional regulators of drug-metabolizing enzymes. Results from HC-AFW1 cells were ...
In comparison with the control group, the patients showed minimal overall cognitive decline and demonstrated less accuracy on one of several tests of attention before the start of treatment and one year later.. All these deficits were associated with symptoms of post-traumatic stress disorder (PTSD), and the effect of having breast cancer on attention lost statistical significance if the effect of post-traumatic stress was taken into account.. In contrast, only patients who had received chemotherapy showed longer reaction times than other participants on a test of alertness at one year. The test required pressing a mouse button whenever a cross appeared on a monitor, and the results were unrelated to PTSD symptoms.. "The difference in performance was minimal - 19 milliseconds, on average - and it may at least partly be due to peripheral neuropathy, damage to the nerves of the fingers caused by certain cytostatic agents," Hermelink explains.. The findings of the Cognicares study suggest that ...
After clinical trials have shown that the new agent is safe and effective, there is reason to make the agent generally available to patients and physicians. The formal process in the U.S. by which this occurs is the approval by FDA of a marketing application (New Drug Application for cytotoxic/cytostatic agents or a Biologic License Application for biological agents) submitted by a private firm; as noted previously, NCI does not submit NDAs or BLAs since it does not market products. The applicant seeks approval from FDA for one or more specific indication(s). Review and approval of an NDA or BLA are based on the demonstration of safety and efficacy assessed from detailed reports of the clinical trials; particularly randomized controlled studies. The contribution of a new agent in the treatment of a disease is demonstrated unambiguously if the agent is the only variable between the treatments ...
Nitric oxide-releasing non steroidal anti-inflammatory drugs (NO-NSAIDs) are a promising class of compounds that cause cell cycle perturbations and induce apoptosis in cell lines from different tumors. We investigated the activity of a recently developed NO-NSAID (NCX 4040) in bladder cancer cell lines (HT1376 and MCR). Cells were treated with different drug concentrations for different exposure times. Cytostatic and cytocidal activity was tested by SRB assay and apoptosis was evaluated by TUNEL analysis, ANNEXIN V assay and fluorescence microscopy. To further investigate the cell death-inducing mechanisms of NCX 4040, we analyzed gp-170, caspase expression and mitochondrial membrane potential (Delta Psi) depolarization. NCX 4040 showed a striking cytocidal activity in both cell lines, reaching LC(50) at a 10-mu M and 50-mu M concentrations in HT1376 and in MCR cells, respectively, after an exposure of only 6 h followed by an 18-h washout. Apoptosis was triggered in up to 90% of cells and was ...
La revue de médecine interne - Vol. 35 - N° 10 - p. 656-663 - Maladies auto-immunes et cancers. Deuxième partie : maladies auto-immunes au cours des cancers et de leur traitement - EM|consulte
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The cytocidal activity of arabinosyl-5-azacytosine (araAC) and its effect on the synthesis and methylation of DNA in the human colon carcinoma cell line HT-29 was examined and compared with three other cytidine analogues. Treatment for 2 hr with 10(-6)M arabinosylcytosine (araC), araAC, 5-azacytidine (AZC), or 2-deoxy-5-azacytidine (dAZC) produced a 7-30% reduction in cell viability. Prolongation of drug exposure to 24 hr significantly enhanced the cytotoxicity of all analogues, and particularly dAZC. AZC and dAZC were potent inhibitors of DNA methylation in the absence of inhibition of DNA synthesis, whereas araC and araAC primarily affected DNA synthesis. RNA synthesis was not affected by any of the analogues. dAZC and AZC were incorporated into DNA to a greater extent than were araC or araAC upon short- and long-term drug exposure, whereas only AZC was incorporated into RNA. These data indicate that araAC appears to behave more as an analogue of araC rather than of dAZC or AZC, wherein it ...
CARDIOVASCULAR DISEASES : Years of life lost from cardiovascular disease = MALADIES CARDIO-VASCULAIRES : Années de vie perdues du fait des maladies cardio- ...
75 years of tradition. The MediClin Robert Janker Clinic is a renowned clinic offering diagnostic radiology and neuroradiology as well as radiotherapy, and in particular high-precision radiotherapy, for the treatment of benign and malignant tumours. We use the latest medical procedures such as stereotactic radiotherapy and brachytherapy, providing our patients with the full spectrum of radiooncological treatment methods using ultramodern equipment.. Centre for high-precision radiotherapy. At the heart of the Radio-Oncological Department is a high-precision radiotherapy system that is available in only a handful of clinics in Germany. This pinpoint-precision machine represents the optimum solution for destroying the actual tumour whilst protecting as much of the surrounding tissue as possible. It even compensates for the tiniest of movements made by the patient during the treatment.. Stereotactic radio surgery (single high-dose radiotherapy) originates from the field of neurosurgery and is now ...
Cytostasis (cyto - cell; stasis - stoppage) is the inhibition of cell growth and multiplication. Cytostatic refers to a cellular component or medicine that inhibits cell growth. Cytostasis is an important prerequisite for structured multicellular organisms. Without regulation of cell growth and division only unorganized heaps of cells would be possible. Chemotherapy of cancer, treatment of skin diseases and treatment of infections are common use cases of cytostatic drugs. Active hygienic products generally contain cytostatic substances. Cytostatic mechanisms and drugs generally occur together with cytotoxic ones. Nitric oxide - activated macrophages produce large amounts of nitric oxide (NO), which induces both cytostasis and cytotoxicity to tumor cells both in vitro and in vivo. Nitric oxide-induced cytostasis targets ribonucleotide reductase by rapid and reversible inhibition. However, other studies show there could be other targets that are responsible for producing long-lasting cytostasis in ...
TY - JOUR. T1 - Exposing primary rat retina cell cultures to γ-rays. T2 - An in vitro model for evaluating radiation responses. AU - Gaddini, Lucia. AU - Balduzzi, Maria. AU - Campa, Alessandro. AU - Esposito, Giuseppe. AU - Malchiodi-Albedi, Fiorella. AU - Patrono, Clarice. AU - Matteucci, Andrea. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Retinal tissue can receive incidental γ-rays exposure during radiotherapy either of tumors of the eye and optic nerve or of head-and-neck tumors, and during medical diagnostic procedures. Healthy retina is therefore at risk of suffering radiation-related side effects and the knowledge of pathophysiological response of retinal cells to ionizing radiations could be useful to design possible strategies of prevention and management of radiotoxicity. In this study, we have exploited an in vitro model (primary rat retinal cell culture) to study an array of biological effects induced on retinal neurons by γ-rays. Most of the different cell types present in retinal tissue ...
Antineoplastic and some other drugs have carcinogenic, mutagenic and/or reproduction toxic effects and effective safety measures are required to protect the employees. In an ongoing research, project founded by the German Berufsgenossenschaft für Gesundheitsdienst und Wohlfahrtspflege (BGW), a repeated ambient monitoring is applied to determine the contamination of the work environment with cytostatic drugs. Main objective of the study is to find out, whether participation in such a regular monitoring programm reduces the contamination level in the long-term. In addition, correlation between factors, such as intensity of preparation activity, work practise, spatial conditions etc. and the drug amounts detected are investigated.. Methods : ...
Les Filières de Santé Maladies Rares FSMR ont été créées suite à lappel à projet du Ministère de la Santé lancé durant lété 2013 (deuxième plan
%DESC. Générique Inspra (Eplerenone 25/50mg) € 1.25 comprimé - Maladies Cardio-vasculaires, Hypertension Artérielle @ Pillstodays. http://pillstodays.com/
Cyto-Set Safer cytostatic preparation and application IV Administration Always a closed system Protect yourself and your environment The number of cytostatic infusions that have to be prepared is growing
The study, published in PNAS, discovered that damaged mitochondria in fruit flies produce a signal which stops nerve cells from working. A gene called HIFalpha was found to regulate the nerve signals from damaged mitochondria and, when this gene was switched off by the research team, nerve function in flies with Parkinsons disease was restored. By deactivating the HIFalpha gene, the early failure of nerve cells caused by mitochondrial damage was prevented ...
Social imbalance in affluent nations is rising while in parts of the emerging world many diseases are waning, Margaret Chan, head of the World Health Organization said on Monday.
There are an astonishing number of individuals with neurological maladies who are relying on scientists to discover new treatments and opportunities for recovery. The prevalence of these conditions is what motivates scientists within Mission Connect, and worldwide, to push the boundaries of our knowledge forward.. ...
Normally, this is on account of one patient with the malady is basically not disconnected from whatever remains of the healing facilitys populace. In different cases, this is on the grounds that the patient just didnt know that they experienced TB at the season of their admission to the office. Most types of TB can be dealt with and limited, however especially forceful strains of the ailment have demonstrated a lot of struggle to anti-toxins that are commonly used to treat the condition.. ...
Yesterday, we learned that Jacoby Ellsbury was dealing with a mild abdomen strain. It wasnt supposed to be a big deal, just a day-to-day sort of malady. Today, an MRI confirmed Ellsburys injury. Although it verified the initial diagnosis, the Yankees … Continue reading →. ...
Doctoral project GA ČR 301/09/H004 "Molecular and structural biology of selected cytostatics. From mechanistic studies to cancer chemotherapy" (2009-2012), J. Koča (PřF MU) co- ...
INTRODUCTION: Cancer and its treatment with cytostatic drugs entails a number of negative experiences, emotions and side effects. Taking care of a oncological patient reveals a strong dependence between the quality of life and the patient's abilities and capabilities to meet their individual needs. OBJECTIVE: Evaluation of the quality of life and assessment of the influence of cancer treatment with cytostatic drugs on the quality of life of patients with blood cancers. MATERIAL AND METHODS: The study was conducted among 50 patients from the Department of Hematology, Blood Cancer and Bone Marrow Transplantation. In order to examine the quality of life of people in the course of treatment with cytostatic drugs in hematological cancers, a diagnostic survey method was implemented with the use of the authors self-designed questionnaire and the EORTIC QLQ-C30 questionnaire in the Polish version. RESULTS: Analysis of the results of the study material reveals that:  almost all the respondents ...
Semantic Scholar extracted view of [Morphological changes in the small intestine mucosa during cytostatic drug treatment]. by Guntram B. Wolff
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La session de formation sur les maladies rares de la peau aura lieu le 22 septembre 2016 à Zagreb, Croatie. Le contenu de cette rubrique est disponible en anglais uniquement, langue officielle de la réunion.
Une étude parue dans The Lancet, menée à linitiative du DNDi (Drugs for Neglected Diseases Initiative) montre que seulement 4% des médicaments et des vaccins enregistrés entre 2000 et 2011 étaient destinés à lutter contre le paludisme, la tuberculose et les autres maladies négligées.
A novel series of (3-diethoxyphosphoryl)isoxazolidines substituted at C5 with various quinazolinones have been synthesized by the 1,3-dipolar cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone with N3-substitued 2-vinyl-3H-quinazolin-4-ones. All isoxazolidines were assessed for antiviral activity against a broad range of DNA and RNA viruses. Isoxazolidines trans-11f/cis-11f (90:10), trans-11h and trans-11i/cis-11i (97:3) showed weak activity (EC50 = 6.84, 15.29 and 9.44 μM) toward VZV (TK+ strain) which was only one order of magnitude lower than that of acyclovir used as a reference drug. Phosphonates trans-11b/cis-11b (90:10), trans-11c, trans-11e/cis-11e (90:10) and trans-11g appeared slightly active toward cytomegalovirus (EC50 = 27-45 μM). Compounds containing benzyl substituents at N3 in the quinazolinone skeleton exhibited slight antiproliferative activity towards the tested immortalized cells with IC50 in the 21-102 μM range.
Aim. The aim of the study was to review the literature on the combination of cytostatics with flavonoids as a promising way to improve the cancer therapy. Material and methods. A review of Polish and foreign literature was performed. The following databases were searched: PubMed, Scopus, Science Direct, and Polish Medical Bibliography. Literature analysis. Effective strategies to inhibit the progression of cancer are needed. Compounds of natural origin, including plant polyphenols, are a part of our diet. Due to their availability, and antioxidant properties, they may serve as efficacious adjuvants in cancer therapy, enhancing the effectiveness of chemotherapeutics. Epidemiological studies have shown an inverse relationship between diets rich in fruits, vegetables, and supplements, and the risk of all causes of death from cancer. Based on their diverse biological activity, flavonoids may be potential adjuvant therapeutic agents that act synergistically with cytostatics for treatment of many ...
Angiogenesis is the formation of new blood vessels from existing vasculature critical for embryonic development and vascular remodeling. trusted to relieve a variety of symptoms including exhaustion and malaria, and it is further thought in Malagasy traditional medication to obtain anticancer and antiviral properties [14, 15]. Preliminary research of isolated derivatives determined capsicodendrin (CPCD) being a lead substance that was extremely soluble and steady in aqueous environment, and with the capacity of exerting cytostatic activity against a wide spectrum of tumor cell types including murine Leukemia cells (L1210/0), individual T-lymphocyte cells (Molt4/C8 and CEM/0), HeLa and HT29 cells at sub-micromolar runs [16]. Many chemotherapeutic agencies have anti-angiogenic properties because they generate cytotoxic or cytostatic results by targeting mobile pathways that promote apoptosis or autophagy [17, 18]. The last mentioned process has very clear roles in a variety of mobile and ...
Angiogenesis is the formation of new blood vessels from existing vasculature critical for embryonic development and vascular remodeling. trusted to relieve a variety of symptoms including exhaustion and malaria, and it is further thought in Malagasy traditional medication to obtain anticancer and antiviral properties [14, 15]. Preliminary research of isolated derivatives determined capsicodendrin (CPCD) being a lead substance that was extremely soluble and steady in aqueous environment, and with the capacity of exerting cytostatic activity against a wide spectrum of tumor cell types including murine Leukemia cells (L1210/0), individual T-lymphocyte cells (Molt4/C8 and CEM/0), HeLa and HT29 cells at sub-micromolar runs [16]. Many chemotherapeutic agencies have anti-angiogenic properties because they generate cytotoxic or cytostatic results by targeting mobile pathways that promote apoptosis or autophagy [17, 18]. The last mentioned process has very clear roles in a variety of mobile and ...
To a greater and greater degree we are now influenced by social realities rather than older physical realities which still require significant muscular activity. Some people rarely go outside in winter because they no longer need to. Yet this avoidance of physical stimuli and muscular activity is comparatively recent, even more so in Strindbergs time.. Unfortunately we may not have evolved a corresponding ability to sit around thinking up useful abstractions. Presumably this is why we arent much good at it. In which case, if we base our society and economy on the intellectual fruits of sitting around we are not likely to build a saner and more rationally reflective world. ...
There is not a doubt now that the fever, which is the prevailing malady among these immigrants, is highly contagious. Mr. Yarwoods (the immigration agent for Montreal) death has already been mentioned, and we are sorry to add that two or three of the doctors here are ill, including Dr. Liddell, the chief emigrant physician. Nineteen of the nuns are said to be more or less sufferers from the prevailing malady, and many of the other nurses have been laid down by fever. The disease is also spreading through the city. ...
The idea is as simple as it is radical: Chronic inflammation, spurred by an immune system run amok, appears to play a role in medical evils from arthritis to Alzheimers, from diabetes to heart
Bryan, I ripped my left rotator throwing square bales about 7-8 years ago (early to mid 50s) and lived with it for a few years. Shots stopped working...
Université de Liège - ULg , Département des maladies infectieuses et parasitaires , Bactériologie et pathologie des maladies bactériennes ,] ...
Saviez-vous que votre bien- tre mental, motionnel et psychologique influence votre vie sexuelle de diverses fa ons ? Ce canal vous fournira tous les renseignements dont vous avez besoin sur la sant sexuelle.
Researchers have developed a low-cost diagnostic platform that is able to detect Zika, dengue and chikungunya within 30 minutes, making it suitable for low-resource clinics in developing countries.
médecine/sciences (M/S), revue internationale dans le domaine de la recherche biologique, médicale et en santé
2006-12-01 Resumen en español Se presenta el caso de una paciente atendida por primera vez a la edad de 37 años, con larga supervivencia superior a los 20 años, a pesar de tener un tumor maligno de la granulosa del ovario tratado de forma combinada con cirugía y tratamiento neoadyuvante y adyuvante de poliquimioterapia. Destaca en el seguimiento de este caso la participación inicial y continuada del Profesor Titular de Ginecología y Obstetricia Dr. Silvano Reyes Fuentes, ejemplo de consagración (mas) y amor a la especialidad, a quien dedicamos el presente trabajo con el respeto y admiración que le guardamos en vida. La operación inicial fue una histerectomía total abdominal con doble anexectomia, a pesar del tratamiento combinado con citostatico presentó varios episodios de recidivas tumorales en la pared abdominal, cúpula vaginal, sigmoides, vejiga e hígado, requirió de 5 reintervenciones con resecciones quirúrgicas, la primera realizada por el Profesor Reyes Fuentes y el resto ...
Ventolin 100 mcg En Ligne France Générique Ventolin Ou Commander A Prix Reduit Ventolin 100 mcg. Ventolin (sulfate dalbutérol) est un médicament mondialement acclamé utilisé pour prévenir et traiter la respiration sifflante, les difficultés respiratoires et loppression thoracique causées par des maladies pulmonaires
INTRODUCTION: Il existe peu dévidences sur lassociation entre le taux de chômage dans le milieu résidentiel (CR) et le risque de maladies cardiovasculaires parmi les résidents de milieux urbains. De plus, on ne sait pas si ce lien diffère entre les ...
This prevention and curing protocol is for people who are ready to take the full responsibility for their own health and are looking for holistic alternatives. It incorporates lifestyle change, and implements healthy diet, body cleansing, exercises and different traditional and natural therapies that may help you overcome this malady. Our aim is to educate you, not medicate you. ...
Vos dons nous permettent de progresser dans la lutte et la guérison de maladies qui figurent encore parmi les premières causes de mortalité dans le monde entier !