Recombinant Dynein, Cytoplasmic 1, Light Intermediate Chain 2 (DYNC1LI2) Protein (His tag). Spezies: Cynomolgus. Quelle: Hefe. Jetzt Produkt ABIN1630642 bestellen.

Redox regulation of nuclear factor κB (NF-κB) has been described, but the molecular mechanism underlying such regulation has remained unclear. We recently showed that a novel disulfide reductase, TRP14, inhibits tumor necrosis factor α (TNFα)-induced NF-κB activation, and we identified the dynein light chain LC8, which interacts with the NF-κB inhibitor IκBα, as a potential substrate of TRP14. We now show the molecular mechanism by which NF-κB activation is redox-dependently regulated through LC8. LC8 inhibited TNF α-induced NF-κB activation in HeLa cells by interacting with IκBα and thereby preventing its phosphorylation by IκB kinase (IKK), without affecting the activity of IKK itself. TNFα induced the production of reactive oxygen species, which oxidized LC8 to a homodimer linked by the reversible formation of a disulfide bond between the Cys2 residues of each subunit and thereby resulted in its dissociation from IκBα. Butylated hydroxyanisol, an antioxidant, and ...

|strong|Mouse anti Human dynein light chain 1 cytoplasmic antibody |/strong|recognizes dynein light chain 1 cytoplasmic, also known as 8 kDa dynein light chain, DLC8 dynein light chain LC8-type 1 and …

Supplementary Materialsrsob170202supp1. centrosome integrity by modulating centrosomal protein localization at the spindle pole. Interestingly, dynein light intermediate chains (LICs) are able to rescue the defects observed in LIMK1-depleted cells. We found that LICs are potential book interacting companions and substrates of LIMK1 which LIMK1 phosphorylation regulates cytoplasmic dynein function in centrosomal proteins transport, which influences mitotic spindle pole integrity. and digital supplementary material, body S3). Open up in another window Body 1. Silencing LIMK1 results in multi-polar spindles. (= 300. The mistake bars represent regular deviation. **** 0.0001, Students = 300. The mistake bars represent regular deviation. **** 0.0001, Students 0.05. (= 300). The test was performed in triplicate. As well as the abnormal amount of centrosomes, cytokinesis failing can result in and multi-nucleated cells aneuploidy. Cells formulated with an abnormal amount of chromosomes are shown in the ...

In this study, we describe the identification of a novel mutation in Dync1h1 in Swl/+ mice, which display an early-onset proprioceptive sensory neuropathy. Detailed comparison of Swl/+ mice with Loa/+ mice, another Dync1h1 mutant, demonstrate that both strains are characterized by a common proprioceptive sensory deficit. Thus, we provide in vivo evidence that dysfunction of cytoplasmic dynein can lead to an early-onset proprioceptive sensory neuropathy in mice.. Cytoplasmic dynein is the major microtubule minus end-directed motor protein, which is composed of two heavy chains (DYNC1H1), two intermediate chains, four light intermediate chains, and several light chains (Karki and Holzbaur, 1999; Hafezparast et al., 2003; Vallee et al., 2004). DYNC1H1 has a C-terminal motor domain head and an N-terminal cargo-binding domain stalk, and homodimerizes at the N-terminal. Most of the accessory subunits of cytoplasmic dynein associate with the N-terminal portion of DYNC1H1. Mediated by dynactin, a ...

Dynein-2 is the motor responsible for retrograde intraflagellar transport. In situ, dynein-2 comprises four subunits: the dynein-2 heavy chain (DYH2); the dynein-2 intermediate chain; the dynein-2 light-intermediate chain (D2LIC); and dynein light chain 8 (Rompolas et al. 2007. Chlamydomonas FAP133 …

DYNC1LI1 antibody [2B6] (dynein, cytoplasmic 1, light intermediate chain 1) for FACS, ICC/IF, WB. Anti-DYNC1LI1 mAb (GTX84599) is tested in Human samples. 100% Ab-Assurance.

This mouse IgG1 monoclonal antibody was generated against human Dynein Light Chain 1 (DYNLT1) and recognizes rat and human homologs ...

View mouse Dynlrb1 Chr2:155236533-155250277 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

DYNLRB1 is essential for dynein mediated transport and neuronal survival: • Depletion of DYNLRB1 impairs neurite outgrowth in sensory neurons. • Complete knocko

There are no specific protocols for Recombinant Human Dynein light chain protein (ab107140). Please download our general protocols booklet

Perform reliable PCR with Bio-Rads Dynlrb2 primer pair, for Mouse. Designed for EvaGreen-based detection with digital PCR (ddPCR).

Human DYNLRB2 (NP_570967, 1 a.a. - 96 a.a.) full-length recombinant protein with His tag expressed in Escherichia coli. (P3426) - Products - Abnova

This sequence change replaces histidine with glutamine at codon 676 of the DYNC1H1 protein (p.His676Gln). The histidine residue is highly conserved and there is a small physicochemical difference between histidine and glutamine. This variant is not present in population databases (ExAC no frequency). This variant has not been reported in the literature in individuals with DYNC1H1-related disease. Algorithms developed to predict the effect of missense changes on protein structure and function do not agree on the potential impact of this missense change (SIFT: Deleterious; PolyPhen-2: Possibly Damaging; Align-GVGD: Class C0). In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance ...

Plasmid 2. p167 Dync1i1.D from Dr. Elizabeth Fishers lab contains the insert cytoplasmic dynein 1 intermediate chain 1 isoform D and is published in PLoS One. 2010 . 5(7):e11682. This plasmid is available through Addgene.

sample_1: Dynein light chain 2A, cytoplasmic, [U-100% 13C; U-100% 15N], 0.6 mM; phosphate buffer 20 mM; NaCl 0.1 mM; EDTA 20 mM; H2O 95%; D2O 5%. sample_2: Dynein light chain 2A, cytoplasmic, [U-100% 13C; U-100% 15N], 0.6 mM; phosphate buffer 20 mM; NaCl 0.1 mM; EDTA 20 mM; D2O 100%. sample_conditions_1: ionic strength: 40 mM; pH: 7.0; pressure: 1 atm; temperature: 298 K ...

View mouse Dync1h1 Chr12:110601452-110666945 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

Abnova DYNC1LI2 293T Cell Transient Overexpression Lysate (Denatured) 100µL Life Sciences:Protein Biology:Proteins:Lysates:Overexpression Lysates D

Fast delivery of DYNC1I1 knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. Includes matched wildtype control.

Fast delivery of DYNC1LI2 knockout Human Cell Lines for the study of gene function. Created by CRISPR/Cas9 genome editing. Includes matched wildtype control.

Use Bio-Rads PrimePCR assays, controls, templates for your target gene. Every primer pair is optimized, experimentally validated, and performance guaranteed.

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.

Plasmid pCB169 from Dr. Iain Cheesemans lab contains the insert dynein light chain TcTex-type 3 and is published in Nat Cell Biol. 2012 Feb 12;14(3):311-7. doi: 10.1038/ncb2440. This plasmid is available through Addgene.

DB-ID: Database ID of variant, grouping multiple observations of the same variant together, starting with the HGNC gene symbol, followed by an underscore (_) and a six digit number (e.g. DMD_012345). _000000 is used for variants where DNA was not analysed (change predicted from RNA analysis), variants seen in animal models or variants not seen in humans but functionally tested in vitro ...

DB-ID: Database ID of variant, grouping multiple observations of the same variant together, starting with the HGNC gene symbol, followed by an underscore (_) and a six digit number (e.g. DMD_012345). _000000 is used for variants where DNA was not analysed (change predicted from RNA analysis), variants seen in animal models or variants not seen in humans but functionally tested in vitro ...

Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.

Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.

DYNC1I1 antibody, N-term (dynein cytoplasmic 1 intermediate chain 1) for WB. Anti-DYNC1I1 pAb (GTX45809) is tested in Human samples. 100% Ab-Assurance.

money : ఇండియాలో పెద్ద బీమా రంగ కంపెనీ గా పేరు తెచ్చుకున్న లైఫ్ ఇన్సూరెన్స్ కార్పొరేషన్ ఆఫ్ ఇండియా LIC జనాలకు ఎన్నో రకాల మంచి మంచి పాలసీలను అందిస్తోంది. ఇక వీటిల్లో పిల్లల దగ్గరి నుంచి సీనియర్ సిటిజన్స్ వరకు కూడా వారికి ఎంతగానో అనువైన చక్కటి పాలసీలు అనేవి ఉన్నాయి.ఇక ఎల్‌ఐసీ మహిళలకు కూడా అదిరిపోయే ఒక ప్రత్యేక పాలసీని అందిస్తోంది. ఇక దీని పేరు ఎల్‌ఐసీ ఆధార్ శిలా.ఈ పాలసీ కేవలం మహిళలకు

To our knowledge, this is the largest WES-related study performed in JATD so far, comprising 71 patients from 57 families. Our data indicate that DYNC2H1 is the most frequent overall cause of JATD, accounting for 33% of the families screened in this study. The high mutation frequency in JATD may be influenced by the size of the DYNC2H1 protein and its central role in ciliary IFT. Since none of the DYNC2H1 patients have many extra-skeletal findings, the frequency could also reflect a higher survival rate of DYNC2H1 patients compared with those carrying mutations in other JATD-related genes.. We identified 34 DYNC2H1 mutations, 30 of which were novel, and found these to occur more frequently in JATD patients of Caucasian and Turkish origin than in patients of African and Asian ethnic background. While DYNC2H1 mutations account for 54% of the Caucasian cases we screened, and 38% of screened Turkish cases, we only detected one case of biallelic DYNC2H1 mutations in other ethnicities (15 cases ...

To our knowledge, this is the largest WES-related study performed in JATD so far, comprising 71 patients from 57 families. Our data indicate that DYNC2H1 is the most frequent overall cause of JATD, accounting for 33% of the families screened in this study. The high mutation frequency in JATD may be influenced by the size of the DYNC2H1 protein and its central role in ciliary IFT. Since none of the DYNC2H1 patients have many extra-skeletal findings, the frequency could also reflect a higher survival rate of DYNC2H1 patients compared with those carrying mutations in other JATD-related genes.. We identified 34 DYNC2H1 mutations, 30 of which were novel, and found these to occur more frequently in JATD patients of Caucasian and Turkish origin than in patients of African and Asian ethnic background. While DYNC2H1 mutations account for 54% of the Caucasian cases we screened, and 38% of screened Turkish cases, we only detected one case of biallelic DYNC2H1 mutations in other ethnicities (15 cases ...

The molecular mechanisms regulating cytoplasmic dynein‐mediated motility are not completely understood, but it is becoming increasingly clear that they involve multiple protein-protein interactions and post‐translational modifications. The dynactin complex, which can be linked to dynein through the interaction of its p150Glued subunit with DIC (Vaughan and Vallee, 1995), might play a role in dynein-cargo binding, e.g. by associating with spectrin (Muresan et al., 2001), and might regulate the processivity of the dynein motor (King and Schroer, 2000). However, dynein itself can also bind to (and transport) various cargoes through its light and light intermediate chains (Tai et al., 1999; Young et al., 2000). We envisage a function for mammalian BICD2 in dynein‐based transport that involves direct binding of BICD2 to the dynamitin subunit of dynactin and association with cytoplasmic dynein. These observations provide a molecular basis for the genetic evidence in D.melanogaster, which ...

Sliding between adjacent microtubules within the axonema gives rise to the motility of cilia and flagella. The driving force is produced by dynein complexes which are mainly composed of the axonemal dynein heavy chains. We used cells of human respiratory epithelium after in vitro ciliogenesis to clone cDNA fragments of nine dynein heavy chain genes, one of which had never been identified before. Dynein heavy chains are highly conserved from protozoa to human and the evolutionary ancestry of these dynein heavy chain cDNA fragments was deduced by phylogenetic analysis. These dynein heavy chain cDNAs are highly transcribed in human tissues containing axonema such as trachea, testis and brain, but not in adult heart or placenta. PAC clones containing dynein heavy chains were obtained and used to determine by FISH their chromosomal position in the human genome. They were mapped to 2p12-p11, 2q33, 3p21.2-p21.1, 13q14, 16p12 and 17p12. The chromosomal assignment of these dynein heavy chain genes which ...

TY - JOUR. T1 - Cytoplasmic dynein function is essential in Drosophila melanogaster. AU - Gepner, Janice. AU - Li, Min Gang. AU - Ludmann, Susan. AU - Kortas, Cynthia. AU - Boylan, Kristin. AU - Iyadurai, Stanley J.P.. AU - McGrail, Maura. AU - Hays, Thomas S.. PY - 1996/3. Y1 - 1996/3. N2 - The microtubule motor cytoplasmic dynein has been implicated in a variety of intracellular transport processes. We previously identified and characterized the Drosophila gene Dhc64C, which encodes a cytoplasmic dynein heavy chain. To investigate the function of the cytoplasmic dynein motor, we initiated a mutational analysis of the Dhc64C dynein gene. A small deletion that removes the chromosomal region containing the heavy chain gene was used to isolate EMS-induced lethal mutations that defined at least eight essential genes in the region. Germline transformation with a Dhc64C transgene rescued 16 mutant alleles in the single complementation group that identifies the dynein heavy chain gene. All 16 alleles ...

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Whole exome sequencing continues to end the diagnostic odyssey for a number of patients and expands our knowledge of phenotypes associated with gene mutations. We describe an 11-year-old female patient with a constellation of symptoms including congenital cataracts, gut dysmotility, sensory neuropathy, and bifrontal polymicrogyria. Whole exome sequencing was performed and identified a de novo heterozygous missense mutation in the ATPase motor domain of cytoplasmic dynein heavy chain 1 (DYNC1H1), which is known to be involved in neuronal migration and retrograde axonal transport. The mutation was found to be highly damaging by multiple prediction programs. The residue is highly conserved, and reported mutations in this gene result in a variety of phenotypes similar to that of our patient. We report only the second case of congenital cataracts and the first of gut dysmotility in a patient with DYNC1H1, thus expanding the spectrum of disease seen in DYNC1H1 dyneinopathies.

The cytoplasmic dynein complex is the major minus-end-directed microtubule motor. Although its directionality is evolutionary well conserved, differences exist among cytoplasmic dyneins from different species in their stepping behaviour, maximum velocity and force production. Recent experiments also suggest differences in processivity regulation. In the present article, we give an overview of dyneins motile properties, with a special emphasis on processivity and its regulation. Furthermore, we summarize recent findings of different pathways for microtubule plus-end loading of dynein. The present review highlights how distinct functions in different cell types or organisms appear to require different mechanochemical dynein properties and localization pathways. ...

The heavy chain 1 of cytoplasmic dynein (DYNC1H1) is responsible for movement of the motor complex along microtubules and recruitment of dynein components. Mutations in DYNC1H1 are associated with spinal muscular atrophy (SMA), hereditary motor and sensory neuropathy (HMSN), cortical malformations, or a combination of these. Combining linkage analysis and whole-exome sequencing, we identified a novel dominant defect in the DYNC1H1 tail domain (c.1792C>T, p.Arg598Cys) causing axonal HMSN. Mutation analysis of the tail region in 355 patients identified a de novo mutation (c.791G>T, p.Arg264Leu) in an isolated SMA patient. Her phenotype was more severe than previously described, characterized by multiple congenital contractures and delayed motor milestones, without brain malformations. The mutations in DYNC1H1 increase the interaction with its adaptor BICD2. This relates to previous studies on BICD2 mutations causing a highly similar phenotype. Our findings broaden the genetic heterogeneity and ...

ScienceDaily (Apr. 10, 2009) - After 12 years of searching, UCLA scientists have tracked down the first known gene mutation responsible for a heartbreaking disorder that kills newborn babies. Published in the April 1 online edition of the American Journal of Human Genetics, their findings will allow for earlier testing of embryos at risk for the disease. Many things go awry in short-rib polydactyly syndrome. The fetus develops extra fingers and toes and its skeleton doesnt grow, resulting in stunted ribs that prevent the lungs from maturing in the womb. Unable to breathe on its own, the child dies shortly after birth ...

Mouse dynein light chain 2A, cytoplasmic ELISA Kit;Mouse Dncl2a ELISA Kit;Mouse DNLC2A ELISA Kit;Mouse 2010012N15Rik ELISA Kit;Mouse 2010320M17Rik ELISA Kit;Mouse 9430076K19Rik ELISA Kit;Mouse AV124457 ELISA Kit;Mouse km23-1 ELISA Kit;Mouse dynein light chain roadblock-type 1 ELISA Kit;Mouse dynein, cytoplasmic, light chain 2A ELISA Kit;Mouse dynein, cytoplasmic, light polypeptide 2A ELISA Kit ...

The dynein intermediate chain (IC) is central to the structure of the dynein motor.2 It is composed of two domains. The extended N-terminal domain (N-IC), is indicated by grey solid and dotted lines. The C-terminal domain (C-IC), which interacts with the heavy chain, forms a relatively ordered and compact beta propeller structure indicated by the grey globular shapes in the figure.. Two copies of IC are present in every dynein motor, and the dimer is bridged by the three light chains LC8, LC7, and Tctex-1. In addition to the light chains, N-IC contains interaction motifs for several other proteins known to be integral to the function of dynein. These include p150Glued, the largest subunit of the dynein activator dynactin, and other proteins such as LIS1 and the ZW10 subunit of the Rod RZZ complex.. With its many interactions, N-IC appears to be the key modulator of dynein assembly and attachment to cargoes. With its extended structure, many interactions, and pivotal role in the function of a ...

Expression of DYNC1H1 (CMT2O, DHC1, DNCH1, Dnchc1, DNCL, DNECL, HL-3, p22) in spleen tissue. Antibody staining with HPA003742 and CAB010443 in immunohistochemistry.

Antibody information for antibodies HPA040619, HPA053987 and CAB033836 used in analysis of ENSG00000077380 / DYNC1I2 (DIC74, DNCI2)

heavy chains, 520 kDa in mass, which contain the ATPase activity and are thus responsible for generating movement along the microtubule two 74 kDa intermediate chains ... The force-generating ATPase activity of each dynein heavy chain is located in its large doughnut-shaped head, which is related to other AAA proteins, while two projections from the ... The alternating activity of the paired heavy chains in the complete cytoplasmic dynein motor enables a single dynein molecule to transport its cargo by walking a ...

Abcam provides specific protocols for Anti-Dynein intermediate chain 1 antibody [74.1] (ab23905) : Flow cytometry protocols, Immunoprecipitation protocols…

Gene List: AARS, AIFM1, ATL1, ATP7A, BICD2, BSCL2, DCTN1, DNAJB2, DNM2, DNMT1, DYNC1H1, EGR2, ELP1, FGD4, FIG4, GAN, GARS, GDAP1, GJB1, GNB4, HARS, HINT1, HSPB1…

Sigma-Aldrich offers abstracts and full-text articles by [Christian Thiel, Kristin Kessler, Andreas Giessl, Arno Dimmler, Stavit A Shalev, Sigrun von der Haar, Martin Zenker, Diana Zahnleiter, Hartmut Stöss, Ernst Beinder, Rami Abou Jamra, Arif B Ekici, Nadja Schröder-Kress, Thomas Aigner, Thomas Kirchner, André Reis, Johann H Brandstätter, Anita Rauch].

TY - JOUR. T1 - Plasmodium falciparum dynein light chain 1 interacts with actin/myosin during blood stage development. AU - Daher, W. AU - Pierrot, C. AU - Kalamou, H. AU - Pinder, J C. AU - Margos, Gabriele. AU - Dive, D. AU - Franke-Fayard, B. AU - Janse, C J. AU - Khalife, J. PY - 2010/6/25. Y1 - 2010/6/25. N2 - Dynein light chain 1 (LC1), a member of the leucine-rich repeat protein family, has been shown to be engaged in controlling flagellar motility in Chlamydomonas reinhardtii and Trypanosoma brucei via its interaction with the dynein γ heavy chain. In Plasmodium falciparum, we have identified the LC1 ortholog, designated Pfdlc1. Negative attempts to disrupt the dlc1 gene by reverse genetic approaches in both P. falciparum and P. berghei suggest either its essentiality for parasite survival or the inaccessibility of its locus. Expression studies revealed high levels of DLC1 protein in late trophozoites and schizonts, pointing to an unexpected role of this protein in blood-stage parasites ...

The correct formation of primary cilia is central to the development and function of nearly all cells and tissues. Cilia grow from the mother centriole by extension of a microtubule core, the axoneme, which is then surrounded with a specialized ciliary membrane that is continuous with the plasma membrane. Intraflagellar transport moves particles along the length of the axoneme to direct assembly of the cilium and is also required for proper cilia function. The microtubule motor, cytoplasmic dynein-2 mediates retrograde transport along the axoneme from the tip to the base; dynein-2 is also required for some aspects of cilia formation. In most cells, the Golgi lies adjacent to the centrioles and key components of the cilia machinery localize to this organelle. Golgi-localized proteins have also been implicated in ciliogenesis and in intraflagellar transport. Here, we show that the transmembrane Golgi matrix protein giantin (GOLGB1) is required for ciliogenesis. We show that giantin is not required ...

Supplementary Figure 1: The level of dynein light chain rp3 is unaffected by the overexpression of WT and mutant Tctex-1. Lysates of MDCK cells inducibly expressing Flag-rp3 and Tctex-1 (WT, S82A, S82E), either harvested from the uninduced (Dox+) or the induced (Dox-) condition, were separated by SDS-PAGE and immunoblotted with anti-rp3 antibody. rp3 was only detected in Flag-rp3-expressing lines cultured under the induced condition. Supplementary Figure 2: High-speed supernatants prepared from homogenates of induced MDCK cell lines were separated by velocity sedimentation on 5-20% sucrose gradients. Aliquots from all fractions were separated on SDS-PAGE and immunoblotted with the indicated Abs. For the endogenous Tctex-1 detection, protein blots were trimmed so that the regions containing Flag-Tctex-1 were removed to avoid antibody sequestration. Low levels of endogenous Tctex-1 were detected in the 19-20S dynein-containing fractions upon prolonged development. LC8 in MDCK cells was primarily ...

Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth | Where is john sutcliffe from article link|cytoplasmic dynein|growth cone|remodeling Best UK Spinal Clinic Surgeons Revolutionary treatments

Mouse Monoclonal Anti-Dynein intermediate chain 2 Antibody (1C8) [DyLight 350]. Validated: WB, ELISA, ICC/IF. Tested Reactivity: Human, Canine. 100% Guaranteed.

This work establishes Lis1 as a dynein regulatory protein and links its function to dynein enzymatic activity. The simplest interpretation of our data is that Lis1 acts specifically and directly on dynein. Although the increase in ATPase activity is modest at first glance, our determination that only one-third of the dynein molecules interacted with Lis1 suggests that there were two populations of motors present in the ATPase assay. The major population did not stably bind Lis1 and is not expected to have had any change in ATPase activity, whereas a smaller population binds Lis1, resulting in a boost in ATPase activity. In this scenario, the enzymatic activity of the dynein as a whole would have increased by only 40%, but the activity of Lis1-associated motors may have increased by ∼100%.. The finding that Lis1 can stimulate dynein in vitro supports our model that Lis1 has an activating influence on dynein in cells (Smith et al., 2000). In our previous work, we found that raising Lis1 ...

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BICD2兔多克隆抗体(ab73286)可与小鼠, 大鼠, 人样本反应并经WB实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。

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