TY - JOUR. T1 - External quality assurance in nongynecologic cytology. T2 - The Australasian experience. AU - Shield, Paul W.. AU - Frost, Felicity. AU - Finnimore, Jo L.. AU - Wright, R. Gordon. AU - Cummings, Margaret C.. PY - 2017/5/1. Y1 - 2017/5/1. N2 - BACKGROUND: The Royal College of Pathologists of Australasia Cytopathology Quality Assurance Program has operated an external quality assurance program in nongynecologic cytopathology since 1993. Glass slide preparations of a wide range of nongynecologic cases were circulated to approximately 200 cytopathology laboratories in 16 countries. METHODS: General nongynecologic cytology cases were manufactured from residual specimens after routine diagnosis. Fine-needle aspiration (FNA) cases were made by sampling fresh tissue and making direct specimens. The majority of cases consisted of both air-dried and fixed preparations. Results returned to laboratories included illustrated case discussions highlighting diagnostic features, key differential ...
Background: The ovaries can be the site for various primary tumors and also the presenting site of metastatic disease. Quick and correct intraoperative diagnosis is crucial for the patients further management. The aim of this study was to demonstrate the advantages of the combined diagnostic method - ovarian frozen sections in conjunction with cytologic smears. Methods: From June 2016 to June 2017, we prospectively prepared additional two cytologic smears with Diff-Quik stain on ovarian frozen sections comprised of two hematoxylin and eosin sections. For quality assurance purposes, we compared the results of frozen section discrepancies and deferrals with those that of the previous year from June 2015 to June 2016. Results: With the introduction of cytologic smears to ovarian frozen sections, the number of discrepancies and deferrals combined decreased from 13.75% to 7.85%. The most benefit of smears was observed in primary ovarian malignancies. Conclusions: In the setting where all the members of the
ThinPrep (TP) and TriPath PREP (TriP) are two liquid-based cytologic preparations that produce a thin layer of cells. This study compares the diagnostic accuracy and different cytomorphologic alterations produced by these preparations in nongynecologic specimens. Samples from 10 urines (3 urothelial carcinomas and 7 negative), 4 positive serous fluids, and 7 fine-needle aspirates (FNAs) were prepared by both techniques. FNAs represented one each of: Hashimotos thyroiditis (HT), hyperplastic colloid nodule (HCN), Hodgkins lymphoma, liposarcoma, chondrosarcoma, squamous-cell carcinoma (SCC) metastatic to the lymph node, and carcinoid tumor. All 5 participants, none of whom had prior knowledge of the clinical history or histologic diagnosis, reviewed and interpreted the slides. Both techniques produced a clean background and were equally accurate in urines, serous fluids, and three FNAs. TriP was slightly more accurate in four FNAs: HCN and HT where colloid and lymphocytes were better represented, SCC
Complementary Examinations. Cancer can only be histologically diagnosed. The treatment of this condition is formulated and initiated only after the histological study has been verified by biopsy, which is a microscopic examination used to confirm or establish this diagnosis. While a direct biopsy can be performed if the tumor is superficial, it may also require limited exploration. This microscopic examination should be completed prior to the initiation of medical treatment or a surgical excision of a large lesion. Once the tissue sample has been attached, histological examination can be performed by experienced histologists. In order to facilitate cytodiagnosis, it is important to obtain tissue samples from palpable tumors. To preserve the structures, the cytodiagnosis requires technical proficiency and proper instrumentation. Although leukemia can be diagnosed by cytology, this examination must be considered as complementary only. While radiographic examinations are used only for orientation ...
Preferred:. Specimen Type: Tissue. Container/Tube: Tissue block. Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block.. Acceptable:. Specimen Type: Tissue. Slides: 1 stained and 10 unstained. Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained, unbaked slides with 5-micron thick sections of the tumor tissue.. Acceptable:. Specimen Type: Cytology. Container/Tube: Cytology slide (Direct smears or ThinPrep). Slides: 1-2 slides (stained and coverslipped) with a minimum of 5,000 total nucleated cells. Collection Instructions: Submit 1-2 slides stained and coverslipped.. Additional Information: Cytology slides will not be returned.. ...
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In this study, sensitivity, specificity, and accuracy of EUS-FNA in the diagnosis of pancreatic and peripancreatic mass lesion was 82%, 89%, and 83%, respectively. This is not substantially different from those of previous studies published abroad reporting sensitivity of 72-94% and specificity of 76-91%.3,7-10 However, inadequacy rate in our study was 12% which is higher than 1.5-4.0% inadequacy rate reported by previous studies. This difference arose because most previous studies unlike ours performed EUS-FNA with the help of on-site cytopathologic evaluation. Inadequacy rate in studies in which on-site cytopathologic evaluation was not available ranged from 9-20% which is similar to our results.5,6 In our study, negative predictive value was low at 46% but negative predictive value has been reported to be low in previous studies also. The low negative predictive value may be reflecting the fact that pancreas cancer comprised for most of lesions. Pancreas cancer when compared with other tumors ...
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
Waiting to hear a possible cancer diagnosis can be very stressful. But a better understanding of the tests doctors use to diagnose and classify cancer may relieve some of your stress. It can also help you work with your doctors to make the best decisions about your treatment.
Imprint is a touch preparation in which the cut surface of the tissue is touched gently on a glass slide which leaves behind its impression in the form of cells. Touch imprint cytology is an important diagnostic tool in surgical oncology. It is reliable and economical providing excellent cellular details. The simplicity, speed and cost effectiveness along with the ability to maximize cell recovery even from a tiny tissue makes imprint cytology a valuable resource in diagnostic medicine. Renal tumors have distinct cytological features that facilitate diagnosis on touch imprint cytology. In the present study, correlation of imprint cytology with histopathological diagnosis was done in three cases of renal tumors. DOI: 10.21276/APALM.1268 ...
TY - JOUR. T1 - Diagnostic value of squamous cell change associated with endometrial carcinoma. T2 - A cytopathologic approach. AU - Toomine, Yukie. AU - Watanabe, Sumiko. AU - Sugishima, Setsuo. AU - Ohishi, Yoshihiro. AU - Tamiya, Sadafumi. AU - Kobayashi, Hiroaki. AU - Sonoda, Kenzo. AU - Oda, Yoshinao. AU - Kato, Kiyoko. AU - Kaku, Tsunehisa. PY - 2016/3/1. Y1 - 2016/3/1. N2 - Background To determine the frequency of squamous cell change associated with endometrial carcinoma, to evaluate the relationship between squamous cell change and clinicopathological features, and to assess cytological findings for squamous cells with and without nuclear atypia in endometrial smears. Methods In 103 cases of endometrioid adenocarcinoma of the endometrium having both histological and cytological specimens, the frequencies and relationships between the presence and absence of squamous cell changes were evaluated, as were the clinicopathological features of such changes. In endometrial smears, squamous ...
Cytodiagnosis is a very complex process, with the final conclusion being dependent on many factors, including: detailed site-specific knowledge; experience of normality; familiarity with the numerous appearances of disease; awareness of mimics and artefacts; clear understanding of the limitations of the technique; and detailed clinical information. 1 Morphology Specimen cellularity provides us with important information about the target organ/tissue. The number and type of cells present give important information about the target tissue. Consequently this represents a prime opportunity to engage in early innovative research in this field. 6 VIRTUAL MICROSCOPY IN EDUCATION 23 we can take these images into the diagnostic arena through the development of automated devices for quantitative assessment. A major consideration in implementing such systems will be the computational challenge in processing these images. The current PC/software framework will simply not provide enough computational power, ...
The Korean Journal of Pathology 2011; 45: 79-86 DOI: 10.4132/KoreanJPathol.2011.45.1.79 Cytologic Features of Prostatic Adenocarcinoma in Urine: Comparison with Urothelial Carcinoma Lucia Kim ∙ Joo Young Song Suk Jin Choi ∙ In Suh Park Jee Young Han ∙ Joon Mee Kim Young Chae Chu Department of Pathology, Inha University School of Medicine, Incheon, Korea Received: March 9, 2010 Accepted: November 19, 2010 Corresponding Author Young Chae Chu, M.D. Department of Pathology, Inha University Hospital, 7-206 Sinheung-dong 3-ga, Jung-gu, Incheon 400-711, Korea Tel: +82-32-890-3984 Fax: +82-32-890-3464 E-mail: [email protected] *This study was supported by Inha University Research Grants. Background: Prostate adenocarcinoma (PACa) cells are rarely identified in urine cytology specimens and might be easily overlooked or misdiagnosed as urothelial neoplasm when clinically unsuspected. Methods: We reviewed 19 urine cytology specimens obtained from 13 patients with PACa and evaluated the characteristic ...
Cytologic examination of the mediastinal lymph nodes was also performed by EBUS-guided aspiration and it was prepared using liquid-based cytology (Thin Prep, Cytyc Corporation, Boxborough, MA, USA) by Papanicolaou stain. The cellularity was relatively low and tumor cells were individually scattered with a few small loosely cohesive clusters on a clean background. A few tumor cells were arranged in vague microacini, linear cords or tight small clusters (Fig. 1F). The nuclear features ranged from a bland nucleus with round borders and fine chromatin to a pleomorphic nucleus with irregular borders and clumped chromatin. The nucleoli were often seen in multiples and appeared small, but distinct. Tumor cells occasionally exhibited binucleation or multinucleation (Fig. 3A) and few Reed-Sternberg cell-like cells with markedly irregular nuclei and prominent nucleoli were identified (Fig. 3B). None of the tumor cells, even pleomorphic cells, exhibited nuclear hyperchromasia. There were no mitotic ...
TY - JOUR. T1 - Identification of human skin from tissue fragments left in various conditions using an enzyme immunoassay for squamous cell carcinoma-related antigen. AU - Kitao, T.. AU - Miyaishi, Satoru. AU - Ishizu, H.. PY - 1997. Y1 - 1997. N2 - We investigated the possibility of identification of human skin left under various conditions using our original enzyme immunoassay (EIA) for squamous cell carcinoma-related (SCC) antigen. The antigen could be detected in specimens under the following conditions: putrefied or dried at room temperature for at least 12 months, immersed in fresh water at room temperature for 3 weeks and heated at 100°C for 72 h.. AB - We investigated the possibility of identification of human skin left under various conditions using our original enzyme immunoassay (EIA) for squamous cell carcinoma-related (SCC) antigen. The antigen could be detected in specimens under the following conditions: putrefied or dried at room temperature for at least 12 months, immersed in ...
Sampling techniques are combined during bronchoscopy to increase the diagnostic yield for endobronchial malignant tumours. Bronchial biopsy provides the definitive histological diagnosis in most cases, but accompanying cytological procedures such as washing, brushing, needle aspiration or imprint cytology can increase diagnostic yield. In this prospective study, a different cytological technique, that could enhance the diagnostic yield of bronchoscopy without increasing its time or cost, was tested. Flexible bronchoscopy was performed in 93 patients suspected of having pulmonary neoplasms. Bronchial biopsies were initially placed in a balanced salt solution. When bronchoscopy was finished, all visible tissue fragments were removed and placed in formalin to undergo histopathological examination and the rinse fluid was sent for cytological examination. Washing was performed routinely but no cytological brushing was employed. Eighty-two patients had final diagnoses of malignant neoplasm. In four ...
Objective: To explore the clinical significance of laparoscopic exploration combined with abdominal exfoliative cytology in the diagnosis and treatment of patients with locally advanced gastric cancer. Methods: Inclusion criteria: (1) cancer confirmed by gastroscopy and pathology without preoperative anti-tumor treatment; (2) no distant metastases found in preoperative imaging examinations; (3) patients without surgical contraindications and being tolerant to surgery; (4) patients were willing to undergo laparoscopic exploration and abdominal exfoliative cytology examination, and signed informed consent. A retrospective cohort study method was used to collect and analyze the clinicopathological data of 225 patients with advanced gastric cancer based on the above inclusion criteria from a prospective, multicenter, open, randomized controlled phase III clinical trial (registration No. NCT01516944) conducted between February 2012 and December 2018 in The Fourth Hospital of Hebei Medical University, ...
TY - JOUR. T1 - Papnet-assisted cytological diagnosis intensifies the already marked variability among cytological laboratories. AU - Mudu, P.. AU - Migliore, G.. AU - Alderisio, M.. AU - Morosini, P.. AU - Douglas, G.. AU - Navone, R.. AU - Montanari, G.. AU - Di Bonito, L.. AU - Vitale, A.. AU - Moretti, D.. AU - Giovagnoli, M. R.. AU - Fulciniti, F.. AU - Branca, M.. PY - 2002. Y1 - 2002. N2 - Objective: The main objective was to assess the sensitivity, specificity and reliability of PAPNET-assisted diagnosis in comparison with conventional screening. Setting: Seven Italian and one English University or Research Institutes, and a random sample of an other 20 Italian Laboratories of the Italian National Health Service (INHS) provided the cervical smears. Methods: During the training phase every center examined in rotation four sets of slides for a total of 300 representative slides. Afterwards, 900 "positive" slides were added to the 3,100 slides which were collected consecutively without any ...
5. WELSHINGER Although the ef ekty paragraphs are pг to the workup and management of known adnexal masses, adnexal masses are often found incidentally at the time of laparotomy for emergent or elective nongynecologic procedures.
TY - JOUR. T1 - LE MODIFICAZIONI CITOLOGICHE INDOTTE DAL TRATTAMENTO DEL CANCRO PROSTATICO. AU - Zattoni, F.. AU - Lembo, A.. AU - Graziotti, P.. PY - 1982. Y1 - 1982. N2 - 257 prostatic needle-biopsies according to Franzens technique were performed on 114 patients with prostatic carcinoma with different stages of differentiation and clinical stages, in order to evaluate the effects of the performed treatment. Some signs of regression may in fact appear either in the nucleus or in the cytoplasm. A good correlation was evidenced among the cellular changes, the clinical condition and the evolution of the disease. In the follow-up of patients treated for prostatic cancer, cytology may provide important information concerning the effects and effectiveness of the treatment.. AB - 257 prostatic needle-biopsies according to Franzens technique were performed on 114 patients with prostatic carcinoma with different stages of differentiation and clinical stages, in order to evaluate the effects of the ...
Hello, We have a pathologist that would like to find an alkaline phosphatase stain that indicates osteosarcoma on a cytology slide. She is wanting it to be a special stain and not an immunohistochemistry stain. We would appreciate any help that you could give us. Thank-you, Diane ...
Immediate fixation of LBC samples improves preservation of cellular morphology and reduces air-drying and crush artefacts compared with CP. Cellular components such as cell membranes and chromatin may appear more sharply defined in LBC preparations than in CP as a result of improved cell preservation. Cell sizes appear slightly smaller in LBC preparations than in CP, however overall cellular morphology is unchanged. Tissue architecture in larger cell groups may be better appreciated in CP compared with LBC, however small cellular clusters and tissue fragments are still preserved.. ...
Mutual competition of nearby organizing regions. The induction of new organizing regions by implantation of tissue fragments derived from the endogenous organizing region has been investigated in the chick [1] (Khaner and Eyal-Giladi, 1989) and extensively in hydra [2,3]. In general, implantation of such tissue at a distance from an existing organizer can be successful, while a more proximal implantation may not. Removal of the endogenous organizing region greatly enhances the probability to form a new organizing region. This behavior is a straightforward consequence of the general pattern forming mechanism proposed, as demonstrated by the following simulations: ...
Cell Block Psycho Prisoner Costume features an orange jumpsuit. Handcuffs and a mask that covers your nose and mouth finish this Prisoner Costume.
It has been a almost 2 weeks since my urologist had ordered a cytology with FISH(?). When he called me originally he caught me off guard so I couldnt think of any questions because I was still in a s...
The examination of brush cytology specimens has become an established diagnostic technique in the investigation of patients with suspected pancreatic, bile duct, gallbladder, and ampullary tumours. We have reviewed 448 consecutive brush samples obtained from 406 patients and correlated the findings with pathological and clinical outcomes. To our knowledge, this is the largest series of pancreatico-biliary brush cytology specimens yet reported.. As with previous studies, we found that the brush cytology technique produced cellular samples of good quality in most instances. Only 26 of 489 (5.3%) specimens were considered inadequate for diagnosis. Seven patients with initial unsatisfactory cytology samples underwent repeat endoscopy and an adequate specimen was obtained in six cases. The number of unsatisfactory specimens has not been specifically noted in many previous studies although rates of 0-6% were documented in three series.9, 11, 18 There was no clear correlation between unsatisfactory ...
Cleveland, Ohio. Diagnoses of specific nongynecologic cytology samples may be enhanced with knowledge of certain laboratory test results. These include both exfoliative samples (cerebrospinal fluid, pericardial, peritoneal and pleural fluids) as well as fine needle aspirate cytology samples from body sites such as the thyroid, "neck," lymph nodes and metastatic sites. Following an overview of the subject, a case-based approach is used to highlight laboratory tests that aid in rendering more specific cytologic diagnoses. The use of immunocytochemical stains on cytologic samples to help make more specific diagnoses are also covered.. ...
Percutaneous tissue removal apparatus comprises a flexible drill shaft, a cutting tip mounted on the shaft for placement adjacent a tissue mass for cutting the tissue, means for transmitting motion to the shaft to move the cutting tip against the tissue to cut tissue fragments from the tissue, and means for removing the tissue fragments along the shaft by suction to a location outside the tissue mass while cutting. The apparatus may include means for collecting one or more selected components of the harvested tissue fragments for implantation of the fragments preferably into the body of the patient from whom they were removed. Where the tissue to be cut is bone, a cutting tip is preferably made of a polymeric material which is softer than the cortical portion of the bone, although the cutting tip may be made of a ceramic or a composite material. A second flexible shaft may be provided either within or about the flexible drill shaft. The harvested tissue fragments may be implanted in the donor patients
Background- Sputum cytology is noninvasive and is the most easily obtainable of the cytologic techniques available. Spontaneous production of significant amounts of sputum often indicates pulmonary disease, both tuberculosis and other respiratory conditions present with similar symptoms. Objective- To describe cytomorphologic changes in sputum samples submitted by TB suspect patients. Settings and Design- Cross-sectional descriptive study. A total 196 TB suspect patients seen at Ngong Sub-District Hospital and Ongata Rongai Health Centre in Kajiado County between December 2011 and March 2012 were assessed for criteria and enrolled in the study. Materials and Methods- Two pre-fixed sputum (Spot and morning) samples were obtained from 196 consecutive pulmonary TB suspect patients, pooled, centrifuged and processed for H&E, Pap and Concentration ZN techniques. Statistical analysis- The data was presented in percentages and charts. The significance of difference was tested using Chi- square test. ...
BACKGROUND Molecular testing of lung adenocarcinomas (ADCs) is crucial for therapy stratification of patients. Because of the often limited diagnostic material, the authors aimed to explore the suitability of cytology smears for next-generation sequencing (NGS) and compared the results with concurrent histological specimens or cell blocks. METHODS A total of 16 formalin-fixed paraffin-embedded (FFPE) ADCs with known genetic alterations were used as the first cohort for targeted DNA and RNA sequencing. In the second cohort of 8 cases, 8 cytological smears were compared with matching histological specimens or cell blocks for the study. For NGS library amplification, commercially available panels for DNA and RNA sequencing were applied. The Ion Torrent Personal Genome Machine and the Ion Reporter workflow (version 5.0) were used for sequencing. RESULTS All DNA libraries derived from FFPE and non-formalin-fixed cytological smear samples produced acceptable quality metrics, thereby enabling ...
An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and inspection. The system includes a first loading station for receiving the sample vials, a second loading station for receiving consumables such as filter membranes, a slide dispenser, and an unloading area for removing completed specimen slides. To maintain one-to-one correlation between the samples and specimens produced therefrom, the system includes a subsystem for identifying each sample and permanently marking each slide with corresponding indicia prior to transferring the specimen thereto.
Discussion. The FNA smears were moderately cellular and composed of a predominant population of spindle cells arranged in large tissue fragments, loose cohesive groups, and as isolated cells (Figure 1). The tumor cells had varying amounts of delicate and pale cytoplasm and indistinct cell membranes. The nuclei appeared elongated and cigar-shaped with blunted-end (Figure 2). There was mild to moderate nuclear atypia in terms of anisonucleosis and prominent nucleoli (Figure 3). A preliminary cytological diagnosis of spindle cell tumor was made. Immunoperoxidase stains were subsequently performed on the cellblock. The tumor cells exhibited strong c-kit (Figure 4) and vimentin immunoreactivity but negative for S-100 protein, smooth muscle actin (SMA) and cytokeratin. A final cytologic diagnosis of GIST was, therefore, made based on cytological and immunocytochemical findings.. Cytologic Diagnosis: Gastrointestinal Stromal Tumor (GIST). Histologic Features. The patient underwent surgical excision ...
Bronchoendoscopic examination is not necessarily comfortable procedure and limited by its sensitivity, depending on the location and size of the tumor lesion. Patients with a non-diagnostic bronchoendoscopic examination often undergo further invasive examinations. Non-invasive diagnostic tool of lung cancer is desired. A 72-year-old man had a 3.0 cm × 2.5 cm mass lesion in the segment B1 of right lung. Cytological examination of sputum, bronchial washing and curetted samples were all "negative". We could confirm a diagnosis of lung cancer after right upper lung lobe resection pathologically, and also obtained concordant results by genomic analysis using cytological negative samples from airways collected before operation ...
Despite progress in recent years towards the early detection of gastric cancer in the western country and Japan, most patients will already have advanced disease at diagnosis in our country. The majority of patients will die of recurrent disease, even if surgery is thought to be curative at the time.. Recent advances in preoperative diagnosis using ultrasonography or computed tomography provide much more information on peritoneal metastasis before operation. However, it is impossible to obtain information about small peritoneal metastasis preoperatively. Therefore, PWC must be performed in addition to macroscopic observation and palpation in patients with advanced gastric cancer. Therefore, cases positive for PWC are considered as peritoneal metastasis, according to the JCGC [10,11].. The prognostic value of positive cytology findings was recently confirmed also in the West, and a new stage classification for gastric carcinoma, recently published by Japanese Gastric Cancer Association, employs ...
Anatomical pathology is the study of organs and tissues to determine the causes and effects of particular diseases. An anatomical pathologists findings are fundamental to medical diagnosis, patient management and research. Anatomical pathology involves macroscopic pathology, histopathology (the combination of these two usually being referred to as "surgical" pathology), cytopathology and morbid anatomy. Histopathology is concerned with the microscopic examination of tissues, taken either as biopsy samples or resection specimens. Tissues are assessed macroscopically, and material is taken for microscopic examination for the purpose of diagnosis, prognosis and directing appropriate treatment. Cytopathology is the study of individual cells aspirated or obtained from body fluids or tissues, including exfoliative cytology, to detect abnormalities. Morbid anatomy is the use of the autopsy to determine cause of death and investigate both the associated and "incidental" (unrelated to cause of death) ...
You have been locked up and on death row for a crime you were wrongfully convicted of 22 years ago. The guards are off the Cell Block attending to an unexpected emergency which caused the lights to go out. You and the other Cell Block 4 inmates are left alone on a honor system that you all will continue to follow protocol. You are set to be executed in a week, so what do you have to lose? You have 60 minutes until the lights are restored back on to escape or you will die trying. Cell Block 4 starts off with your group being divided in 4 separate locked cells.. Duration: 60 minutes. Price: $31 per person, up to 12 people in a game. Minimum Participants: The minimum number of participants to play this game is at least 4 persons. Note: Participants 13 years and younger must be booked with an adult in a private room booking so no other groups join the game. ...
This is a temporary file and hence do not link it from a website, instead link the URL of this page if you wish to link the PDF file ...
Background: EBUS-TBNA is performed to harvest cytologic and core-biopsy specimens in patients with mediastinal lesions. Rapid cytologic examinations of the sample are expected to increase the diagnostic rates. We studied the value of USB microscope as Rapid On-site Microscopic Evaluation (ROME) of core-biopsy specimens.. Methods: We performed ROME in 20 core-biopsy specimens sampled by EBUS-TBNA. The specimens were divided into five groups according to the microscopic findings. The group I was classified when whitish tumor islets were not found. The group II has one or several tiny suspicious tumor islets. The group III has less than 5 visible tumor islets, the group IV 5 - 10, and the group V more than 10 tumor islets. The ROME was compared with the final pathologic examination. Results: Among 20 specimens, 3 (15%) were in group I, 2 (10%) in group II, 5 (25%) in group III, 7 (35%) in group IV, and 3 (15%) in group V, respectively. When compared with the pathologic examination, clinical ...
Collection and cytological analysis of gynaecological smears, gastrointestinal, respiratory, and urinary tract cytology, fine needle aspiration cytology. Theory and application of transmission and scanning electron microscopy. Diagnostic electron microscopy. Procedures for the preparation of muscle, nerve and bone for histopathological assessment. Principles and uses of immunohistochemistry. Pathology of urinary system, neuro-muscular pathology. Principles of image analysis and morphometry.. ...
Immunocytochemistry/immunofluorescence (ICC/IF) is a technique that uses fluorescent antibodies or dyes to detect target antigens within cells. ​This protocol describes the procedure for ICC/IF of suspension cells using ...
Speciman preparation for microscope slide EAnimals plants etc. MeCan provide best online selection of quality specimens for microscope observation.
野口 和美 , 森山 正敏 , 三浦 猛 , 木下 裕三 , 窪田 吉信 , 穂坂 正彦 Eighty-six cases of cytological diagnosis of the prostate by fine needle aspiration performed between January, 1986 and December, 1987 were reviewed. Twenty patients were diagnosed as positive cytolog … 泌尿器科紀要 35(3), 399-401, 1989-03 IR Ichushi Web ...
Titles in this series - The subspecialty of Cytopathology is 60 years old and has become established as a solid and reliable discipline in medicine. As expected, cytopathology literature has expanded in a remarkably short period of ...
There are many methods to detect thyroid cancer, besides the main examinations like X-ray, ultrasound examination and cytological examination, a patient can check it himself.
About 50% of the general population presents nodules in the thyroid gland. Although 90% of such nodules are benign, the cytological examination of
Cerebrospinal fluid has a very important role in diagnosing various neurologic diseases. Since there are no official protocols concerning the turnaround time (TAT) for emergency tests of CSF and also no information on pre-analytical influence on test results, the main objective of this Thesis was to evaluate the influence of CSF time sampling on cytological results combined with influence of cell elements on biochemistry test results.The cell numbers were analyzed according to three different time intervals. After a 60-minute interval, the cells were counted in the Fuchs-Rosenthal counting chamber and with Sysmex XE 5000 Analyser, whereas only the Fuchs-Rosenthal counting chamber was used for measurements after 61-90 and after 91-120 minute time intervals. The biochemistry tests were conducted immediately upon the receipt of the samples and within the time interval of 91-120 minutes, both in a native sample without performing a centrifugation and in the supernatant without the cells after ...
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Cytopathology is the use of specialist diagnostic techniques to examine individual cells extracted from tissues to determine the cause and nature of a disease.
The lymph nodes were being grossly abnormal, reliable, nodular masses (Figure 1C), from which a touch preparing confirmed tiny, atypical cells with scant cytoplasm and distinguished nucleoli (Determine 1D). Histologic assessment showed effacement of typical architecture by irregular, crowded nests of smaller, atypical cells (Determine 1E). Syncytia containing atypical nuclei ended up present within the periphery from the nests (Determine 1F). The individual cells had scant cytoplasm and measured five to six μm in diameter (a bit scaled-down than the usual human pink mobile), with nuclei that were about 2 to 3 μm in diameter. Occasional cells ended up markedly enlarged, with pleomorphic nuclei containing multiple nucleoli (Figure 1G ...
The lymph nodes were grossly irregular, stable, nodular masses (Determine 1C), from which a touch preparing showed little, atypical cells with scant cytoplasm and outstanding nucleoli (Determine 1D). Histologic assessment confirmed effacement of typical architecture by irregular, crowded nests of small, atypical cells (Determine 1E). Syncytia made up of my response atypical nuclei ended up existing with the periphery on the nests (Determine 1F). The person cells had scant cytoplasm and measured 5 to 6 μm in diameter (slightly lesser than the usual human crimson cell), with nuclei that were approximately 2 to 3 μm in diameter. Occasional cells were markedly enlarged, with pleomorphic nuclei get more made up of several nucleoli (Determine 1G ...
The lymph nodes have been grossly abnormal, sound, nodular masses (Figure 1C), from which a contact preparing confirmed little, atypical cells with scant cytoplasm and outstanding nucleoli (Determine 1D). Histologic assessment confirmed effacement of ordinary architecture by irregular, crowded nests of compact, atypical cells (Determine 1E). Syncytia containing atypical nuclei had been existing within the periphery of your nests (Determine 1F). The person cells had scant cytoplasm and calculated 5 to 6 μm in diameter (marginally more compact than the usual human purple cell), with nuclei that were roughly two to three μm in diameter. Occasional cells ended up markedly enlarged, with pleomorphic nuclei that contains multiple nucleoli (Determine 1G ...
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চিকিত্সা ব্যয় এবং চিকিত্সা ভ্রমণ ব্যয় জড়িত ভারতের সেরা হাসপাতালগুলি থেকে Fnac পদ্ধতি সম্পর্কে পরামর্শ নিন। শীর্ষ হাসপাতালের পর্যালোচনা পড়ুন।
A total of 113 fine needle aspirates of the breast masses were evaluated in which the subsequent biopsy or mastectomy specimen were also available for histological examination. The age ranged from 16 to 80 years with a mean of 42 years. In benign conditions the mean age was 34.7 years while in malignant cases it was 48 years. The cytological diagnoses were compared with the histological results which revealed that the specificity and sensitivity of fine needle aspiration cytology in the palpable breast lesions was 86.1% and 89.2% respectively with a positive predictive value of 93% and efficiency of 88.2%. Similar statistics from other series in which the cytological results of breast lesions were compared with histological results, revealed almost same results which suggest that fine needle aspiration cytology is an effective and accurate technique for the diagnosis and management of palpable breast lumps.
Fine needle aspiration cytology (FNAC) and open biopsy of same enlarged lymph nodes were performed in 59 patients with lymphadenopathy. When histopathological and cytological examinations were compared, an accuracy of 91.5% was achieved with FNAC in the cases of lymphadenopathy of various etiologies. Thus, fine needle aspiration cytology being reliable, safe, rapid and economical procedure, is useful as an outdoor diagnostic procedure for diagnosing lymphadenopathy of various etiologies.
Purpose To study cytomorphology and cytologic diagnostic criteria of bone malignant lymphoma(MLB) by fine needle aspiration cytology(FNAC). Methods To use multiform stainings to observe the cytologic samples and compared with histologic results of same patients to analyse the morphologic appearances. Results Of eight cases of bone non Hodgkins lymphoma, seven were accurately diagnosed by FNAC, they showed monotypic immatare lymphocytes in cytomorphology. Conclusion The cytologic result to diagnose MLB by FNAC is dependable. The diagnostic basis of cytomorphology is consistent with cytologic diagnostic criteria of lymphoma.
HTGFN : An adjunct to cytologic examination of fine-needle aspiration specimens in athyrotic individuals treated for differentiated thyroid cancer, to confirm or exclude metastases in enlarged or ultrasonographically suspicious lymph nodes   This test is not useful for screening asymptomatic individuals for neoplastic disease.
An automated screening system and method for cytological specimen classification in which a neural network is utilized in performance of the classification function. Also included is an automated microscope and associated image processing circuitry.
Dr. Shyam Prasad Reddy .D. Reader. Awards & Honors:. 1. Awarded best poster award for "Confocal Microscopy and exfoliative cytology: Opening doors to the new era" at the National IAOMP Conference, New Delhi, November 2009.. 2. Topped in the university exams in the deparartment of Oral Pathology in Part I (72.5%) December 2008 and in Part II (68%) September 2009.. 3. Honored by "Channagiri Virupakshappa Dharmashala trust" for scoring highest marks in the final year B.D.S for the academic year 2003-2004. 4. Received merit scholarship from Ministry of Human Resources and Development, Department of Education, Government of India under National Scholarships Scheme in 1998-99.. Scientific Publications Published. 1. Reddy DS, Sherlin HJ, Ramani P, Prakash PA. Determination of sex by exfoliative cytology using acridine orange confocal microscopy: A short study. J Forensic Dent Sci. 2012; 4(2):66-9. doi: 10.4103/0975-1475.109887. PMID: 23741144 [PubMed] PMCID: PMC3669479.. 2. Pasupula AP, Dorankula SP, ...
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Cytologic Findings: The smears were cellular and revealed cohesive sheets of tumor cells, some forming papillary groupings with tumor cells surrounding capillaries. In addition, a necrotic background with tumor diathesis was appreciated (Figure2, nodified Giemsa stain). The tumor cells were round to polygonal in shape with increased nuclear to cytoplasmic ratios, moderately pleomorphic nuclei and a moderate amount of basophilic cytoplasm (Figure 3, modified Giemsa stain). Intranuclear and intracytoplasmic vacuoles were seen. An Ultra-Fast Papanicolaou (UFP) stain revealed enlarged nuclei with multiple prominent nucleoli (Figure 4). A helpful cytologic feature was the presence of abundant metachromatic basement membrane-like material in the background (Figure 5, arrow, modified Giemsa stain).. Diagnosis: NONSEMINOMATOUS GERM CELL TUMOR-YOLK SAC TUMOR Histologic Findings: A cell block preparation of the aspiration biopsy revealed predominantly microcystic areas (Figure 6, hematoxylin and eosin ...
Cytologist definition, the study of the microscopic appearance of cells, especially for the diagnosis of abnormalities and malignancies. See more.
Define gastric smear. gastric smear synonyms, gastric smear pronunciation, gastric smear translation, English dictionary definition of gastric smear. Noun 1. gastric smear - alimentary tract smear of material obtained from the stomach alimentary tract smear - any of several cytologic smears obtained from...
The principal findings of this study are the following: (a) the results of FISH/CISH analysis done on small-sized specimens represent a successful method for establishing the EGFR/HER2 gene content in NSCLC; (b) as reported in the literature, gain of EGFR and HER2 genes is more frequently a consequence of Chr7 and Chr17 polysomy, respectively, rather than gene amplification; and (c) concurrent polysomy and, less specifically, concurrent trisomy of EGFR and HER2 may be considered as positive markers for selecting NSCLC patients eligible for TKI treatment.. The first aim of our study was to validate the EGFR/HER2 gene study by FISH or CISH in very small tissue samples of lung cancers. In our series, in 68% of cases, the first diagnosis of NSCLC was obtained from small biopsies or cytologic samples. This limited the possibility of characterizing the histotype of tumors in 7% of cases. Several studies have reported successful use of FISH and CISH in alcohol-fixed fine-needle aspiration cytology or ...
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of biocompatible, bioresorbable granules and at least one tissue fragment in association with the granules. The tissue fragment contains one or more viable cells that can migrate from the tissue and populate the tissue carrier matrix. Also provided is a method for injectably delivering the tissue implant.
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Serial pancreatic juice aspiration cytologic examination (SPACE) by nasopancreatic tube placement can give us an opportunity to diagnose early-stage pancreatic cancer with higher sensitivity and...
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Neurosurgery . Östergötlands Läns Landsting, Reconstruction Centre, Department of Neurosurgery UHL. ...
Please follow the policy for the processing of specimens for Cytopathology as outlined in the Specimen Submission Manual document "Processing of Specimens for Cytopathology" (PDF attached for download).. Download PDF: Processing of Specimens for Cytopathology 2011. Safety: Universal precautions are followed.. Contact: ...
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The Cytopathology department of The Johns Hopkins University School of Medicine and The Office of Medical Informatics have created this site to enhance the teaching program at the School of Medicine in regards to the Cytopathology course.
The Cytopathology department of The Johns Hopkins University School of Medicine and The Office of Medical Informatics have created this site to enhance the teaching program at the School of Medicine in regards to the Cytopathology course.
pregnancy accounting , control and prenatal process running according to modern requirements (including priority registration for pregnant women), health assessment (Sonography, Doppler examination, laboratory tests, cervical cytological examination), hereditary disease screening (by instruction also: Amniocentesis), fetal assessment (biophysical profile, KTG-research), professional advice on diet and lifestyle for the mother, and maternal and fetal health monitoring and evaluation. The department documents the whole period of pregnancy and proves final documentation. ...
As this eMedTV page explains, lung cancer screening is used to detect cancer before symptoms develop. This article explains the benefits and risks associated with screening, which is normally done with chest x-rays or a procedure known as sputum cytology.
As this eMedTV page explains, lung cancer screening is used to detect cancer before symptoms develop. This article explains the benefits and risks associated with screening, which is normally done with chest x-rays or a procedure known as sputum cytology.
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Diagnostic fiberoptic endoscopic examination of lower respiratory tract with biopsy lavage and brush cytology of lesion of lower respiratory tract (procedure ...
Pris: 633,-. E-bok, 2012. Leveres direkte via nedlastning . Kjøp boken Serous Cavity Fluid and Cerebrospinal Fluid Cytopathology av Syed Z. Ali, Edmund S. Cibas (ISBN 9781461417767) hos Adlibris.com. Fri frakt.
The lymph nodes ended up grossly irregular, reliable, nodular masses (Determine 1C), from which a touch preparation confirmed modest, atypical cells with scant cytoplasm and notable nucleoli (Figure 1D). Histologic assessment showed effacement of typical architecture by irregular, crowded nests of little, atypical cells (Determine 1E). Syncytia that contains atypical nuclei had been present for the periphery of the nests (Figure 1F). The person cells had scant cytoplasm and calculated five to six μm in diameter (marginally smaller than the usual human purple mobile), with nuclei that were somewhere around two to three μm in diameter. Occasional cells were markedly enlarged, with pleomorphic nuclei containing many nucleoli (Determine 1G ...
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When preparing a slide for morphologic examination, what is the reason for adding a drop of albumin to the cerebrospinal fluid (CSF) sample prior to cytocentrifugation?. Please select the single best answer ...
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Chordomas are rare tumors that are usually located in the sacrococcygeal and sphenooccipital region. Their cytologic diagnosis is rather straightforward when sampled by fine-needle aspiration (FNA) from these characteristic locations, especially when physalipherous cells are present. However, chordomas may pose difficult diagnostic challenges when encountered in unusual locations, such as the parapharyngeal region. We report the cytologic findings of a recurrent chordoma sampled through transoral FNA from the parapharyngeal space of a 66-year-old woman. As the prior history of chordoma was not available during the rapid onsite evaluation, the presence of bland epithelioid nonvacuolated cells and spindle cells intimately admixed with a fibrillary, intensely metachromatic material led to an initial diagnosis of pleomorphic adenoma. Review of the patients prior pathology specimen and of the Papanicolaou-stained smears and cellblock sections showing rare multivacuolated (physalipherous) cells led ...
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Fine-needle aspiration biopsy of lymph nodes. Fine-needle aspiration biopsy (FNAB), when performed by trained operators, and for the correct indications, is a safe and minimally invasive procedure, with an excellent diagnostic ...
TY - JOUR. T1 - Cytologic features of infarcted thyroid papillary carcinoma induced by fine needle aspiration. AU - Jang, Se Min. AU - Jun, Young Jin. AU - Na, Woong. AU - Jang, Ki Seok. AU - Paik, Seung Sam. PY - 2010/1/1. Y1 - 2010/1/1. KW - Aspiration biopsy, fine-needle. KW - Carcinoma, papillary. KW - Infarction. KW - Thyroid neoplasms. UR - http://www.scopus.com/inward/record.url?scp=78650508591&partnerID=8YFLogxK. M3 - Letter. C2 - 21053614. AN - SCOPUS:78650508591. VL - 54. SP - 1082. EP - 1083. JO - Acta Cytologica. JF - Acta Cytologica. SN - 0001-5547. IS - 5. ER - ...
SUMMARY: The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. There were 14 patients with a history of thyroid cancer, 7 with mucosal squamous cell carcinoma, 1 with renal cell carcinoma, 1 with parotid acinic cell cancer, 1 with metastatic colon adenocarcinoma, and 2 with no history of cancer. Intraoperative transoral sonography was performed using a commercially available endovaginal transducer. A transoral sonography-guided fine-needle aspiration was performed with a 25-cm-long 20-ga Chiba needle through a needle guide attached to the transducer shaft. Cytopathologic results were categorized as malignant, benign, or nondiagnostic. Transoral sonography ...
By Dr Rishu Agarwal, MD (Pathology)Fine needle aspiration cytology (FNAC) is a diagnostic procedure where a needle is inserted into your body, and a small amount of tissue is sucked out for examin
This book discusses a broad selection of interesting cases of fine needle aspiration cytology (FNAC), which offer valuable insights into the diagnosis of cytology cases in routine practice. It provide
Background: More than half of women present nipple discharge during reproductive age. Case: This case is about a 36 years old woman with unilateral spontaneous hyaline nipple discharge associated with breast pain. The study of scintimammography was compatible with multifocal proliferative lesion in situ. It was performed cytological smear of nipple discharge. It was paucicellular smear represented by cluster of ductal cells in three-dimensional design with hyperchromatic nuclei in the presence of myoepithelial cells. Red cells and signs of necrosis were not observed. The diagnosis of in situ ductal carcinoma was confirmed in biopsy and mastectomy specimen through the expression of calponin in myoepithelial cells at immunohistochemistry. It is known that the cytological examination of nipple discharge has low sensitivity and specificity. However, it is an easy and inexpensive procedure. Suspicious or positive results, may be important for guidance workup of patients in order to perform earlier ...
The present study evaluated the prevalence of important HPV types in a local cohort of participants from Southern Bavaria, and analyzed the HPV type distribution in participants with abnormal cytological diagnostic findings, who were separated by various age groups. It is well known that the distribution of HPV types varies around the world (14), and it is hypothesized, based on a pooled analysis from women with normal cytological findings in various studies, that the prevalence of HPV16 is more prominent in Europe and North America, compared with other regions of the world (12,14,33,34). In the current study, HPV infection was detected in 76.42% of participants with an abnormal cytological finding. In total, 89.15% of participants were infected with ≥1 HR-HPV, which is significantly higher than the incidence previously reported in a similar study conducted in Italy (68.90%) (35). However, it taken into consideration the fact that the present study classified more HPV types as HR-HPV than the ...
1. The finding of a false‐negative sample is not necessarily evidence of practice below the standard of care. The decision as to whether a false‐negative GYN cytology sample is the result of negligence should be made not only on the basis of evaluation of a single sample but should also include an evaluation of the patients past clinical history and previous GYN cytology results. The test results should also be viewed in the context of the accredited laboratorys overall performance on GYN cytology samples.. 2. Atypical cells of undetermined significance represent an equivocal interpretive category with poor inter‐ and intra‐observer reproducibility. Therefore, most cases of ASCUS (atypical squamous cells of undetermined significance) and AGUS (atypical glandular cells of undetermined significance) do not represent consistently identifiable abnormalities and a reasonable basis for allegations of practice below a reasonable prudent practitioner standard of care.. 3. Pap test slides being ...
DNA from archival Papanicolaou stained smears was successfully amplified using the polymerase chain reaction (PCR) to see if it could be used for retrospective genome studies such as detection of the presence of human papilloma virus (HPV) and changes in p53 gene expression. DNA was isolated and purified by treatment with proteinase K, phenol/chloroform, and isoamyl alcohol. Segments of the human beta actin and TGF beta 1 gene were amplified by PCR. Of all stains used in the preparation of Papanicolaou smears, only eosin was detectable as a greenish band in ethidium bromide treated DNA gels under ultraviolet illumination.. ...
Optimizing the development of targeted agents in pancreatic cancer: Tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays Academic Article ...