|strong|Mouse anti Human Cytochrome B245 Heavy Chain antibody, clone NL7|/strong| recognizes the heavy chain of cytochrome B245, also known as gp91phox or NOX2, a subunit of the nicotinamide adenine d…

References for Abcams Recombinant Human Cytochrome b5 protein (ab56987). Please let us know if you have used this product in your publication

CYB5R2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 299 amino acids (1-276 a.a.).

Mouse monoclonal antibody raised against native CD63. Cell preparation of human cytochrome B enriched cells. (MAB4993) - Products - Abnova

The small heme-containing protein cytochrome b5 can facilitate, inhibit, or have no effect on cytochrome P450 catalysis, often in a P450-dependent and substrate-dependent manner that is not well understood. Herein solution NMR was used to identify b5 residues interacting with different human drug-metabolizing P450 enzymes. NMR results revealed that P450 enzymes bound to either b5 α4-5 (CYP2A6 and CYP2E1) or this region and α2-3 (CYP2D6 and CYP3A4) and suggested variation in the affinity for b5 Mutations of key b5 residues suggest that not only are different b5 surfaces responsible for binding different P450 enzymes, but that these different complexes are relevant to the observed effects on P450 catalysis ...

Complete information for CYB5A gene (Protein Coding), Cytochrome B5 Type A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Gene target information for CYB561D1 - cytochrome b561 family member D1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Synonyms: cytochrome b558 subunit beta (human) superoxide-generating NADPH oxidase heavy chain subunit (human) neutrophil cytochrome b 91 kDa polypeptide (human) cytochrome b(558) subunit beta (human) gp91-1 (human) gp91-phox (human) hCYBB NADPH oxidase 2 (human) heme-binding membrane glycoprotein gp91phox (human) CGD91-phox (human) ...

1I5U: Effects of charged amino-acid mutation on the solution structure of cytochrome b(5) and binding between cytochrome b(5) and cytochrome c.

1EHB: Crystal structure of recombinant trypsin-solubilized fragment of cytochrome b(5) and the structural comparison with Val61His mutant.

Sulc M, Jecmen T, Snajdrova R, Novak P, Martinek V, Hodek P, Stiborova M, Hudecek J. Mapping of interaction between cytochrome P450 2B4 and cytochrome b5: the first evidence of two mutual orientations. Neuro Endocrinol Lett. 2012 Jan; 33(Suppl 3): 41-47 ...

A major category of mutant hematopoietic phenotypes in Drosophila is melanotic tumors or nodules, which consist of abnormal and overproliferated blood cells, similar to granulomas. Our analyses of the melanotic mutant dappled have revealed a novel type of gene involved in blood cell regulation. The dappled gene is an essential gene that encodes cytochrome b5, a conserved hemoprotein that participates in electron transfer in multiple biochemical reactions and pathways. Viable mutations of dappled cause melanotic nodules and hemocyte misregulation during both hematopoietic waves of development. The sexes are similarly affected, but hemocyte number is different in females and males of both mutants and wild type. Additionally, initial tests show that curcumin enhances the dappled melanotic phenotype and establish screening of endogenous and xenobiotic compounds as a route for analysis of cytochrome b5 function. Overall, dappled provides a tractable genetic model for cytochrome b5, which has been ...

Our site contains information on Cytochromes P450, Cytochromes b5, NADPH-Cytochrome P450 reductases, β-Glucosidases, and Glycosyltransferases (Family 1). Follow any of the links above for more information, or check our recent updates. The four structures shown above are links to the P450 (upper left), UGT (upper right), P450 reductase (lower left), and cytochrome b5 (lower right) sections of our site. Molecular images are made using UCSFs Chimera and Adobe Photoshop. Our last site update was on November 29, 2010 Areas Updated Recently: ...

Order Cytochrome B Reductase 1 ELISA Kits for many Reactivities. Human, Mouse and more. Compare Cytochrome B Reductase 1 ELISA Kits and find the right product on antibodies-online.com.

Cytochrome b reductase 1兔多克隆抗体(ab66048)可与小鼠, 人样本反应并经WB, IHC, ICC/IF实验严格验证并得到2个独立的用户反馈。所有产品均提供质保服务，中国75%以上现货。

In bc complexes, cytochrome b plays a major role in electron transfer and in proton translocation across the membrane. Several inhibitor-resistant and respiratory-deficient mutants have already been used to study the structure-function relationships of this integral membrane protein. We describe here the selection and the molecular analysis of revertants from a thermo-sensitive mit-mutant of known nucleotide changes. Among 80 independent pseudo-wild type revertants screened by DNA-labelled oligonucleotide hybridization, 33 have been sequenced. Eight suppressor mutations, affecting a region critical for both the function and the binding of center o inhibitors (end of helix C) were identified. Two of them were found to be more resistant to myxothiazol. ...

Tail-anchored (TA) proteins are a unique class of functionally diverse membrane proteins defined by their single C-terminal membrane-spanning domain and their ability to insert post-translationally into specific organelles with an Ncytoplasm-Corganelle interior orientation. The molecular mechanisms …

Rabbit Polyclonal Anti-Cytochrome b reductase 1 Antibody. Validated: WB. Tested Reactivity: Human, Rhesus Macaque. 100% Guaranteed.

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.

Cytochrome b5 is a membrane-bound hemoprotein which acts as an electron carrier for several membrane-bound oxygenases [1]. There are two homologous forms of b5, one found in microsomes and one found in the outer membrane of mitochondria. Two conserved histidine residues serve as axial ligands for the heme group. The structure of a number of oxidoreductases consists of the juxtaposition of a heme-binding domain homologous to that of b5 and either a flavodehydrogenase or a molybdopterin domain. These enzymes are: ...

Principal Investigator：YUBISUI Toshitsugu, Project Period (FY)：1991 - 1992, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：General medical chemistry

CYB5R3_ENST00000402438 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, CYB5R3_ENST00000402438 Genome Browser, CYB5R3_ENST00000402438 References

An improved method for introducing point mutations into the mitochondrial cytochrme b gene to facilitate studying the role of cytochrome b in the formation of reactive oxygen species / B. Trumpower28 ...

Cyt b5 protein acts as an electron donor to the Cyt P450 enzyme and is required for full activity of the Cyt P450 enzyme Flavinoid 3 5 hydroxylase in vivo and the generation of purple/ blue flower colours ...

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The electron transfer properties of proteins are normally measured as molecularly averaged ensembles. Through these and related measurements, proteins are widely regarded as macroscopically insulating materials. Using scanning tunnelling microscopy (STM), we present new measurements of the conductance through single-molecules of the electron transfer protein cytochrome b562 in its native conformation, under pseudo-physiological conditions. This is achieved by thiol (SH) linker pairs at opposite ends of the molecule through protein engineering, resulting in defined covalent contact between a gold surface and a platinum-iridium STM tip. Two different orientations of the linkers were examined: a long-axis configuration (SH-LA) and a short-axis configuration (SH-SA). In each case, the molecular conductance could be gated through electrochemical control of the heme redox state. Reproducible and remarkably high conductance was observed in this relatively complex electron transfer system, with ...

TY - JOUR. T1 - Identification of mammalian blood meals in mosquitoes by a multiplexed polymerase chain reaction targeting cytochrome B. AU - Kent, Rebekah J.. AU - Norris, Douglas. PY - 2005/8. Y1 - 2005/8. N2 - To date, no polymerase chain reaction diagnostic technique exists to directly identify mammalian blood meals from mosquitoes by sized DNA fragments following agarose gel electrophoresis. We have developed a vertebrate-specific multiplexed primer set based on mitochondrial cytochrome b to identify the mammalian blood hosts of field-collected mosquitoes. Although designed for the study of African malaria vectors, the application of this tool is not restricted to this disease system. Validation of this diagnostic technique on dried anopheline and culicine field specimens collected in Zambia and Mali demonstrated that blood meals could be identified 2-7 months after collection. Time course experiments showed that host DNA was detectable in frozen mosquito abdomens 24-30 hours post-feeding. ...

The outer membrane form may mediate the reduction of outer membrane cytochrome b5, and the soluble inter-membrane space form may transfer electrons from external NADH to cytochrome c, thereby mediating an antimycin-insensitive, energy-coupled oxidation of external NADH by yeast mitochondria. Involved in the reduction of D-erythroascorbyl free radicals.

Hirawake H et al. (1997) Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23.. ...

Target AntigenCytochrome b245 Light Chain Quantity0.1ml Clone44.1HostMouse ImmunogenTissue / cell preparation (Human): Partially Purified human neutrophil flavocytochrome b (heparin Ultrogel/lectin affinity purification - in Triton X-100)Myeloma/fusion partnersSP2/0Species ReactivityHumanPurificationProtein G purifiedF

우리나라는 전 세계 녹용의 약 80% 이상을 소비하고 있는 양록 대국이나 최근 국내 녹용시장에서의 녹용 둔갑판매 및 불법유통 현상이 문제점으로 대두되고 있다. 따라서 본 연구는 녹용의 종 감별 기술을 개발하고자 현재 국내에서 유통되고 있는 러시아산 원용, 북미산 대록, 국산화용, 중국산 깔깔이 및 알래스카산 순록 등 5종의 대표적인 녹용들을 대상으로 종간 염기서열 변이성이 매우 높은 유전자로 알려져 있는 mt DNA내 cytochrome b 및 D-loop 유전자 영역의 염기서열 분석 및 종간 변이성 비교분석을 수행하였다. 각 녹용시료에서 mt DNA를 분리하고 cytochrome b와 D-loop유전자의 특정 영역을 포함하는 primer를 설계 합성하고 PCR로 증폭한 후 DNA 증폭산물의 염기서열을 분석하여 종간 유전정보의 동일성 여부를 비교한 결과 녹용 종간에 명확한 차이를 보이는 염기서열

Cytochromes P450 (P450s) belong to a superfamily of heme-containing monooxygenases and are the predominant enzyme responsible for phase I metabolism of clinically relevant drugs (Wang and Tompkins, 2008). Through the incorporation of a single oxygen atom, P450s generate products that are more water-soluble and are either readily excreted in the urine or more amenable substrates for phase II conjugation. Previous studies have demonstrated that many of these enzymes are highly flexible (Domanski and Halpert, 2001; Zhao and Halpert, 2006), allowing them to accommodate a wide range of substrates, including numerous steroids, pharmaceuticals, and environmental pollutants (Johnson and Stout, 2005).. P450 2B enzymes were among the first mammalian P450s to be purified and cloned and have served as a prototype for biochemical and biophysical experiments, as well as studies of substrate specificity and of interactions with the redox partners NADPH-cytochrome P450 reductase and cytochrome b5 (Zhao and ...

Indra R, Moserova M, Kroftova N, Sulc M, Martinkova M, Adam V, Eckschlager T, Kizek R, Arlt V, Stiborova M. Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. Neuro Endocrinol Lett. 2014 Jan; 35(Suppl 2): 105-113 ...

A heme-thiolate protein (cytochrome P-450). The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22. The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6, adrenodoxin-NADP+ reductase ...

encoding the small sub-unit, p22-phox protein, of the cytochrome b 558 of the NADPH oxidase that plays a crucial role in NADPH-dependent reactive oxygen species ...

MemProtMD simulation of Cytochrome B6F Complex in a lipid bilayer at both coarse-grained and atomistic respresentation, including both file download and analysis. Classification based on PDB 2d2c.

Schöttler, M. A.; Toth, S. Z.; Boulouis, A.; Kahlau, S.: Photosynthetic complex stoichiometry dynamics in higher plants: biogenesis, function, and turnover of ATP synthase and the cytochrome b(6)f complex. Journal of Experimental Botany 66 (9), S. 2373 - 2400 (2015 ...

मुंबई: बॉलीवुड अभिनेत्री रकुल प्रीत सिंह ड्रग्स केस में पूछताछ के लिए एनसीबी टीम के सामने पहुंच गई हैं।रकुल प्रीत से पूछताछ का ये पहला दिन हैं रकुल प्रीत सिंह को एनसीबी के सामने कल ही आना था लेकिन समन...

TY - JOUR. T1 - Recombinant PsbF from Synechococcus sp. PCC 7002 forms β. T2 - β homodimeric cytochrome b559. AU - Yu, Xin. AU - Tan, Ping. AU - Shen, Gaozhong. AU - Zhao, Jindong. PY - 2003/12/1. Y1 - 2003/12/1. N2 - All organisms with oxygenic photosynthesis contain two photosystems: photosystem I (PS I) and photo-system II (PS II). The minimal photosystem II particles which are photochemically active contain three subunits: D1, D2 and cytochrome b559 (Cyt b559). The function of Cyt bS59 remains unclear. We have successfully overexpressed the psbF gene, encoding the β subunit of Cyt b559, from a marine cyanobacteriuni Synechococcus sp. PCC 7002 as a fusion gene and obtained a redox-active form of Cyt b559. When the N-terminal GST protein of the fusion gene product was removed with thrombin, the PsbF protein was still redox-active, suggesting that the recombinant PsbF can form dimer in Escherichia coli. The absorption spectra of either the oxidized form or the reduced form of both GST fusion ...

We have previously described the development of genetic models to study the in vivo functions of the hepatic cytochrome P450 system, through the hepatic deletion of either cytochrome P450 oxidoreductase (POR; HRN line) or cytochrome b5 (Cyb5; HBN line). However, HRN mice still exhibit low levels of mono-oxygenase activity, in spite of the absence of detectable reductase protein. To investigate whether this is because cytochrome b5 and cytochrome b5 reductase can act as sole electron donors to the P450 system, we have crossed HRN with HBN mice to generate a line lacking hepatic expression of both electron donors (HBRN). HBRN mice exhibited exacerbation of the phenotypic characteristics of the HRN line - liver enlargement, hepatosteatosis and increased expression of certain cytochrome P450s. Also, drug metabolising activities in vitro were further reduced relative to the HRN model, in some cases to undetectable levels. Pharmacokinetic studies in vivo demonstrated that midazolam half-life, Cmax and ...

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.

Cytochrome b reductase 1 antibody, C-term (cytochrome b reductase 1) for IHC-P. Anti-Cytochrome b reductase 1 pAb (GTX89592) is tested in Human, Mouse samples. 100% Ab-Assurance.

1999 (English)In: Biochemistry, ISSN 0006-2960, E-ISSN 1520-4995, Biochem, Vol. 38, 10578-10584 p.Article in journal (Refereed) Published ...

Mouse polyclonal antibody raised against a full-length human CYB5R1 protein. CYB5R1 (NP_057327.2, 1 a.a. ~ 305 a.a) full-length human protein. (H00051706-B01P) - Products - Abnova

The major b-type cytochrome in microsomal membrane preparations from developing endosperm of castor bean (Ricinus communis) was cytochrome b5. Cytochrome P-450 was also present. The microsomal membranes had delta 12-hydroxylase activity and catalysed the NAD(P)H-dependent hydroxylation of oleate to yield ricinoleic acid. CO had no effect on the hydroxylase activity. Rabbit polyclonal antibodies were raised against the hydrophilic cytochrome b5 fragment purified from cauliflower (Brassica oleracea) floret microsomes. The anti-(cytochrome b5) IgG inhibited delta 12-hydroxylase, delta 12-desaturase and cytochrome c reductase activity in the microsomes. The results indicate that electrons from NAD(P)H were transferred to the site of hydroxylation via cytochrome b5 and that cytochrome P-450 was not involved. ...

TY - JOUR. T1 - Studies on methemoglobin reductase. Immunochemical similarity of soluble methemoglobin reductase and cytochrome b5 of human erythrocytes with NADH-cytochrome b5 reductase and cytochrome b5 of rat liver microsomes. AU - Kuma, Fumio. AU - Prough, Russell A.. AU - Masters, Bettie Sue Siler. PY - 1976/2. Y1 - 1976/2. N2 - An antibody preparation elicited against purified, lysosomal-solubilized NADH-cytochrome b5 reductase from rat liver microsomes was shown to interact with methemoglobin reductase of human erythrocytes by inhibiting the rate of erythrocyte cytochrome b5 reduction by NADH. The ferricyanide reductase activity of the enzyme was not inhibited by the antibody, suggesting that the inhibition of methemoglobin reductase activity may be due to interference with the binding of cytochrorme b5 to the flavoprotein. Under conditions of limiting concentrations of flavoprotein, the antibody inhibited the rate of methemoglobin reduction in a reconstituted system consisting of ...

Looking for online definition of Cytochrome-b5 reductase5in the Medical Dictionary? Cytochrome-b5 reductase5explanation free. What is Cytochrome-b5 reductase5 Meaning of Cytochrome-b5 reductase5medical term. What does Cytochrome-b5 reductase5mean?

Upon incubation of detergent-solubilized NADPH-cytochrome P-450 reductase and either cytochrome b5 or cytochrome c in the presence of a water-soluble carbodiimide, a 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC), covalently cross-linked compl

Autor: Kobayashi, K. et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 2002-08; Titel: Monolayer formation of cytochrome b(562) on gold surfaces and its reconstitution reaction, studied by surface plasmon resonance spectroscopy

Cytochrome b-245 heavy chain also known as cytochrome b(558) subunit beta or NADPH oxidase 2 or Nox2 is a protein that in humans is encoded by the CYBB gene. The protein is a super-oxide generating enzyme which forms reactive oxygen species (ROS). Nox2, or Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Nox2 is the catalytic, membrane-bound subunit of NADPH oxidase. It is inactive until it binds to the membrane-anchored p22phox, forming the heterodimer known as flavocytochrome b558. After activation, the regulatory subunits p67phox, p47phox, p40phox and a GTPase, typically Rac, are recruited to the complex to form NADPH oxidase on the plasma membrane or phagosomal membrane. Nox2 itself is composed of an N-terminal transmembrane domain that binds two heme groups, and a C-terminal domain that is able to bind to FAD and NADPH. There has been recent evidence that it plays ...

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www.MOLUNA.de Cytochrome P-450 [4208648] - Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and

SWISS-MODEL Repository entry for A1YLR8 (CYB_AVACL), Cytochrome b. Avahi cleesei (Cleeses woolly lemur) (Bemaraha woolly lemur)

Vogl, C.; Panou, I.; Yamanbaeva, G.; Wichmann, C.; Mangosing, S. J.; Vilardi, F.; Indzhykulian, A. A.; Pangršič, T.; Santarelli, R.; Rodriguez-Ballesteros, M. et al.; Weber, T.; Jung, S.; Cardenas, E.; Wu, X.; Wojcik, S. M.; Kwan, K. Y.; Del Castillo, I.; Schwappach, B.; Strenzke, N.; Corey, D. P.; Lin, S. Y.; Moser, T.: Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. The EMBO Journal 35 (23), pp. 2536 - 2552 (2016 ...

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