TY - JOUR. T1 - Collision tumor of the appendix. T2 - mucinous cystadenoma and carcinoid. A case report. AU - Dellaportas, D.. AU - Vlahos, Nf. AU - Polymeneas, G.. AU - Gkiokas, G.. AU - Dastamani, C.. AU - Carvounis, E.. AU - Theodosopoulos, T.. PY - 2014. Y1 - 2014. N2 - INTRODUCTION: Mucinous cystadenoma is the most common of benign neoplasms of the appendix and carcinoid is the most common type of primary malignant lesions of the appendix.We report a rare case of a 57-year-old female with combined mucinous cystadenoma and carcinoid tumor of the appendix.Dual carcinoid and epithelial neoplasia is a rare occurrence in the appendix.CASE REPORT: A 57-year-old Caucasian woman presented after incidentally palpating a mass on her right iliac fossa. Imaging modalities revealed a cystic tumor in the right iliac fossa with a diameter of about 8 cm, originating either from the right ovary or the appendix. She underwent laparoscopic surgical exploration, which revealed appendiceal mucocele and ...
Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate into a frank cancer. Most patients with these tumors are in their 5th and 6th decade and it is more common in women. Most of these tumors occur in the body and tail of the pancreas. As with serous cystadenomas they can usually be definitely diagnosed with modern diagnostic testing. When small (,3cm) and asymptomatic, most experts feel these lesions can be safely observed provided there is close surveillance with CT scans. If the lesion is ,3cm, causing symptoms or obstructing the pancreatic duct they should be surgically excised. Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed.. ...
A close-up of the smooth appendiceal luminal surface is shown. Differential diagnosis included mucocele, mucinous cystadenoma, mucinous cystadenocarcinoma and less likely, carcinoid ...
A mucocele of the appendix is a descriptive term that refers to dilation of a lumen because of accumulation of a large amount of mucin. It is a rare lesion in all resected appendiceal tumors. Schistosomiasis of the appendix is also a rare lesion and is observed in 0.4% of all appendectomies performed [7]. Simultaneous giant mucinous cystadenoma of the appendix and intestinal schistosomiasis is extremely rare. To our knowledge, this is the first case ever to be reported in the world.. The characteristic pathological tissue response of appendiceal schistosomiasis is believed to be a granulomatous inflammatory reaction to the schistosomal ova. There is formation of epithelioid cell granulomas, predominantly in the submucosa and serosa, which ultimately undergo fibrosis. The final pathologic examination of the present case revealed calcified Schistosome eggs within the mucosa, submucosa of the appendix, small intestine, colon, and lymph nodes. Considering that mucoceles are caused by mucus ...
Mucinous cystadenoma is a type of tumor that usually develops in the ovaries, pancreas, or appendix. Its typically benign, but...
TY - JOUR. T1 - Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas. AU - Raimondo, Massimo. AU - Tachibana, Issei. AU - Urrutia, Raul. AU - Burgart, Lawrence J.. AU - DiMagno, Eugene P.. PY - 2002/10/1. Y1 - 2002/10/1. N2 - OBJECTIVES: Intraductal papillary mucinous tumor (IPMT) is frequently associated with pancreatic cancer. We hypothesized that IPMT progresses to invasive cancer with K-ras mutations as an early event, and that invasive cancer affects survival. We compared survival after resection and determined whether K-ras mutations predicted survival in IPMT patients without or with invasive cancer. METHODS: Records of 47 patients with IPMT who were seen between 1983 and 1998 were reviewed retrospectively in 15 cases and prospectively in 32. All histological material was reviewed to confirm the diagnosis of IPMT and to assess invasion. Kaplan-Meier survival curves were analyzed by the log-rank test. The X2 test was used for differences in K-ras between ...
TY - JOUR. T1 - High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters. AU - Sugio, Kenji. AU - Gazdar, Adi F.. AU - Albores-Saavedra, Jorge. AU - Kokkinakis, Demetrius M.. PY - 1996. Y1 - 1996. N2 - Ductal adenocarcinoma, the most common form of pancreatic cancer in humans, is associated with activation of the K-ras oncogene in ~90% of cases. In contrast, K-ras mutations are found in ,50% of the relatively rare intraductal papillary mucinous tumor (IPMT), which arises in the main pancreatic ducts. Since both adenocarcinomas and IPMTs are believed to arise from ductal cells and progress through similar sequences of morphological changes (i.e. flat hyperplasia, papillary hyperplasia, atypia and carcinoma in situ), it is clear that such progression may not always necessitate activation of the ras oncogene. Experimentally ductal adenocarcinomas of the ...
TY - JOUR. T1 - Cystadenomas of the pancreas. T2 - Is enucleation an adequate operation?. AU - Talamini, Mark Adams. AU - Moesinger, Robert. AU - Yeo, Charles J.. AU - Poulose, Benjamin. AU - Hruban, Ralph H.. AU - Cameron, John L.. AU - Pitt, Henry A.. PY - 1998/6/1. Y1 - 1998/6/1. N2 - Objective: The objective was to determine whether surgical enucleation of mucinous cystadenoma of the pancreas is a safe and adequate operation. Summary Background Data: Mucinous cystadenomas of the pancreas are premalignant cystic lesions. Resection is the preferred treatment but often requires a pancreatoduodenectomy or a distal pancreatectomy with or without a splenectomy. Although these procedures can now be performed with a low mortality rate, substantial morbidity still occurs, especially in patients who have an otherwise normal pancreas. Methods: Between January 1990 and June 1997, 36 mucinous cystadenomas of the pancreas were resected at The Johns Hopkins Hospital. Most of these patients underwent ...
SPEN(Solid and papillary epithelial neoplasm of pancreas) 10-20대 여성(흑인)에서 주로 발생, low malignant potential * CT : large cystic tumor of pancreas * Gross : solitary, large(8-10cm), pseudocapsule cross-section: solid & cystic component 내부에 hemorrhage & necrosis동반 * Micro : uniform eosinophilic granular cytoplasm round to oval nuclei with indistinct nucleoli mitotic rate↓ IPMT(Intraductal papillary mucinous tumor) = mucinous ductal ectasia pancreas head에 주로 생기고 남자에 많다. pancreatitis를 잘 일으키며 ERCP상 duct dilatation내에 filling defect(mucin)으로 나타난다. ERCP에서 ampulla of Vater로 mucin이 흘러내리는 것을 관찰할수 있다. premalignant lesion으로 수술적 절제가 필요하다. mucin fluid에 CA 19-9가 증가해 있다. Cystic neoplasm serous & mucinous cystic neoplasm의 두 종류가 있으며 serous neoplasm은 benign, mucinous neoplasm은 premalignant lesion이다. 둘다 중년 여성에 많고, ...
Answer: Mucinous cystadenoma. Histology: none provided. Discussion: This cystic mass is partially denuded and partially lined by benign mucinous epithelium. The wall is thick and fibrotic with chronic inflammation. Focal areas with aggregates of foamy histiocytes and granulation tissue are also noted in the cyst lumen. No extravasated mucin or ovarian type stroma is identified. The tumor is adherent to the serosal surface/deep aspect of muscularis propria of the colon. The appendix and ascending colon were unremarkable. Immunostains demonstrate that the mucinous epithelium is CK7+, CK20-, and MUC2- but MUC5+ and beta-catenin negative. This staining pattern is most consistent with an ovarian type mucinous neoplasm. Since no ovarian tissue was submitted and as per the surgeon the tumor was away from the ovaries these findings may represent a mucinous cystadenoma arising in ectopic ovarian tissue.. ...
Case presentation: A 68-year-old Italian man was admitted to our unit complaining of macrohematuria, rectorrhagia, and rectal tenesmus for about 2 months. A colonoscopy showed the presence of a rectal lesion at 11cm from the anal margin; multiple biopsies were performed and a diagnosis of moderately differentiated adenocarcinoma was made. Abdominal ultrasonography and total body computed tomography performed subsequently to stage the rectal cancer showed the presence of two round nodules, interpreted as swollen lymph nodes of neoplastic origin, at the anterior aspect of the iliopsoas muscle and a budding lesion affecting the bladder. The patient underwent transurethral biopsy of the lesion in the right retrotrigonal region; the diagnosis was grade II urothelial carcinoma. The patient underwent an open anterior rectal resection with loco-regional lymphadenectomy. An enlarged appendix and a voluminous whitish soft-tissue lesion requiring an appendicectomy were detected perioperatively. ...
Adnexa masses occur in one out of two hundred pregnancies(1). Many are benign ovarian cysts diagnosed in womenduring antenatal care and managed conservatively with success.Occasionally, ovarian accidents occur that necessitateemergency surgeries. However, in women, unbooked duringpregnancy, presentation to hospital may occur for the firsttime in the puerperium and it may pose
A 71-year-old woman was referred to our institution for further investigation of epigastric pain. The patient had been detected to have a multilocular cyst in the medial segment of the liver measuring 69 mm in diameter at another hospital 2 years ago, and the diameter of the cyst had increased to 90 mm. Although the cyst had gradually increased in size, there was no evidence of mural nodules. As we were concerned about the malignant potential of the lesion, a left hepatic segmentectomy was performed. Pathologically, the cyst was lined by columnar and cuboidal epithelium with low-grade atypia. The epithelium covered an ovarian-like stroma, and the diagnosis was mucinous cystic neoplasm of the liver (MCN-L) with low-grade intraepithelial neoplasia. MCN-L is a rare disease and its characteristics are still poorly understood. MCN-L occurs at a lower frequency as compared to the counterpart of MCN of the pancreas, further investigations are necessary to clarify the biological malignancy of MCN-L.
Kayla Rahn couldnt lose weight and started experiencing a lot of pain. A 50-pound cyst was to blame. Doctors had not seen a such a large mucinous cystadenoma.
Answer: Mucinous cystic neoplasm. Histology: This unusual neoplasm is has two distinct components. The stroma has the appearance of ovarian stroma, and indeed the stromal cells immunolabeled for estrogen and progesterone receptors. The second component is composed of epithelial cells. These cells are mostly cuboidal and occasionally have a "hobnail" appearance.. Discussion: Mucinous cystic neoplasms of the pancreas occur in women more frequently than they do in men, and mucinous cystic neoplasms have a distinctive "ovarian-type" of stroma. The neoplasm presented arose in a woman and it has ovarian stroma. One might expect that it is a classical mucinous cystic neoplasm, but two things are peculiar about this case. First, the epithelial cells do not form large cysts. Second, the epithelial cells are not columnar mucin-producing cells. Instead, they are mostly cuboidal and somewhat hob-nailed in appearance. This histologic appearance is almost identical to the mixed epithelial and stromal tumor ...
TY - JOUR. T1 - Clinical presentation of mucin-secreting tumors of the pancreas. AU - Tibayan, Frederick (Fred). AU - Vierra, Mark. AU - Mindelzun, Bob. AU - Tsang, Don. AU - McClenathan, James. AU - Young, Harvey. AU - Trueblood, H. Ward. PY - 2000/5/15. Y1 - 2000/5/15. N2 - Background: Pancreatitis and jaundice secondary to ductal obstruction are common in intraductal papillary mucinous tumors (IPMT) of the pancreas. However, the incidence and severity of the complications of obstruction are not well documented. The aim of the study was to investigate the clinical presentation and outcome of 10 patients with IPMT. Methods: All cases of IPMT diagnosed between 1994 and 1999 were reviewed. Results: Four of the 10 patients developed severe acute illness with systemic complications resulting from ductal obstruction. Three suffered acute cholangitis with sepsis, and 1 developed necrotizing pancreatitis and ARDS. There was 1 postoperative death in a patient with adenocarcinoma. All other patients are ...
Age over 70 (p = 0.031) and CA 19-9 over 300 U/mL (p = 0.015) were shown as significant predictors of malignancy. BMPCN with mural nodule (p = 0.002) and abrupt change of the bile duct (p = 0.027) was more likely in malignancy. Age over 70 (OR: 6.37, 95% CI: 1.15-35.2, p = 0.034), CA19-9 over 300 U/mL (OR: 3.97, 95% CI: 1.12-14.0, p = 0.032) and mural nodule over 20mm (OR: 10.32, 95% CI: 1.54-68.7, p = 0.016) were independent predictors of malignancy. The lesion that had more than 2 of 4 points (age over 70, CA19-9 over 300 U/mL, mural nodule over 20mm and abrupt change of the bile duct) had high accuracy for predicting malignancy (sensitivity: 84.2%, specificity: 83.3%, AUC = 0.867). ...
Note: Borderline cystadenomas M-8442, 8451, 8462, 8472, 8473, of the ovaries moved from behavior /3 (malignant) to /1 (borderline malignancy) in ICD-O-3. SEER registries are not required to collect these cases for diagnoses made 1/1/2001 and after. However, cases diagnosed prior to 1/1/2001 should still be abstracted and reported to SEER. ...
Note: Borderline cystadenomas M-8442, 8451, 8462, 8472, 8473, of the ovaries moved from behavior /3 (malignant) to /1 (borderline malignancy) in ICD-O-3. SEER registries are not required to collect these cases for diagnoses made 1/1/2001 and after. However, cases diagnosed prior to 1/1/2001 should still be abstracted and reported to SEER. ...
Compagno J, Oertel JE. Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases. Am J Clin Pathol. 1978 Mar; 69(3):289-98.. ...
Pancreatic mucinous cystic neoplasm, also mucinous cystic neoplasm of the pancreas and mucinous cystic tumour, is a grouping of cystic neoplasms that arise from the pancreas. They may be benign, malignant or in between. The prognosis of this set of tumours is highly variable and dependent on the specific sub-classification (benign, borderline, malignant). Mucinous cystic neoplasms of the pancreas are defined by the World Health Organization (WHO) as cystic epithelial neoplasms that occur almost exclusively in women; do not communicate with the pancreatic ductal system and which are composed of columnar, mucin-producing epithelium, supported by ovarian-type stroma. This means that these tumors make mucin (a thick sticky fluid), they do not arise in the larger pancreatic ducts, and they have a peculiar supporting stroma (or support structure). Mucinous cystic neoplasms of the pancreas classified as benign, borderline, or malignant, based on histomorphological features which predict their ...
Biliary cystadenomas are benign but potentially malignant cystic neoplasms, which classically contain mesenchymal stroma similar to ovarian tissue. We report a case of an extra-hepatic biliary cystadenoma with mesenchymal stroma along with a discussi
Histologically, cystoadenomas are characterised by the presence of cysts lined with mucinous cuboidal or columnar epithelium.6 An ovarian-type stroma is seen in 85% of cases and exclusively in females.4 A marsupial pseudocapsule separates the cystadenoma from the biliary epithelium.4 Elevated levels of CA 19-9 and/or CEA have been reported within the cysts themselves.1 2 4 11 12. Although the biliary cystadenoma is a benign entity, malignant transformation can occur, leading to cystadenocarcinoma.4 Sarcomatous transformation has also been described in one case.6 It has been suggested that cystadenocarcinomas arising from biliary cystadenomas with ovarian-type stroma have a relatively indolent course, whereas cystadenomas without ovarian-type stroma have a poorer prognosis.4. Most commonly, on radiologic imaging, these neoplasms appear as multi-loculated, multi-septated intrabiliary neoplasms. They are usually large at the time of presentation, with a mean tumour size of 15 centimetres.4 On CT, ...
A 53-yr-old woman with a history of hepatic cystadenoma 25 yr before presented with a simple hepatic cyst, which evolved over 9 yr into a complex cystadenoma with septations and internal bleeding. She was treated with a left hepatectomy. Review of the literature shows that hepatic cystadenomas, although rare, frequently can recur years later and have potential for malignant transformation. Histologic similarities of one variant with ovarian stroma raises interesting possibilities regarding the origin of these lesions. The best treatment results are obtained with radical excision ...
Vujaklija Brajković, Ana and Zlopaša, Ozrenka and Brida, Vojtjeh and Gašparović, Vladimir (2015) Resolution of polyserositis after removal of appendix mucinous cystadenoma. Tohoku Journal of Experimental Medicine, 235 (1). pp. 25-8. ISSN 0040-8727 Gašparović, Hrvoje and Petričević, Mate and Đurić, Željko and Brida, Vojtjeh and Jelašić, Dražen and Biočina, Bojan (2014) Amyloidosis of the aortic root in a patient with polyarteritis nodosa. Collegium Antropologicum, 38 (3). pp. 1051-3. ISSN 0350-6134 Gašparović, Hrvoje and Zupančić-Salek, Silva and Brida, Vojtjeh and Dulić, Grgur and Jelić, Ivan (2007) Aortic valve replacement in a patient with severe hemophilia. Collegium antropologicum, 31 (1). pp. 355-357. ISSN 0350-6134 (Print) ...
Symptoms. Mucinous Cystadenocarcinomas are more common in the body and tail of the pancreas. They can be more prominent then 10 centimeters. Guess with this kind of pancreatic cancer for the most part better. Pancreatoblastomas are uncommon (0.5 percent) exocrine tumors commonly found in children under 10 years of age, however it can happen all through lifetime. Pancreatoblastomas are recognized all the more regularly in guys and Asians. They show up as a group of cells among ordinary cells. Survival is superior to with adenocarcinoma.. Serous Cystadenomas are ordinarily kindhearted tumors. They have a wipe like improvement and can be cumbersome. They are loaded with watery fluid, while mucinous cystadenomas are loaded with a thicker sticky liquid. Serous cystadenomas comprise of single or different growths averaging 5-8 cm and upwards to 25 cm in breadth. Papillary Tumors are uncommon with an inclination for young ladies principally between 19 - 50 years of age. It is a huge round very much ...
Struma ovarii is a rare ovarian tumor defined by the presence of thyroid tissue comprising more than 50% of the overall mass. It most commonly occurs as part of a teratoma, but may occasionally be encountered with serous or mucinous cystadenomas.
Struma ovarii is a rare ovarian tumor defined by the presence of thyroid tissue comprising more than 50% of the overall mass. It most commonly occurs as part of a teratoma, but may occasionally be encountered with serous or mucinous cystadenomas.
There are many different types of ovarian cysts. The most common are physiological cysts, also known as "simple" or "functional" cysts, because they form as part of normal ovarian processes. There are two types of simple cysts: follicular cysts, which form when an ovarian follicle (egg sac) doesnt release its ovum (egg) and fills up with clear fluid; and luteal cysts, which form in ruptured follicles and are more likely to cause spotting, heavy bleeding or early/late periods. Both follicular and luteal cysts usually disppear on their own. With polycystic ovarian syndrome, lots of little cysts form all over the ovarys surface. The first signs of the condition include heavy bleeding and irregular periods and, over time, these cysts can affect fertility. This condition is generally treated hormonally. Other benign cysts include hormone-producing cysts, serous and mucinous cystadenomas, fibromas and Brenner tumours. Most of these should be surgically removed once discovered. In all cases, ...
Kosmahl M, Wagner J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 2004 Mar;28(3):339-46 ...
Cystic neoplasms of the pancreas represent about 10% of all cysts of the pancreas and ~1% of all pancreatic neoplasms. Much has been learned about the natural history and management of these tumors in the past decade. We are finding more of these lesions than in years past since so many patients receive ultrasounds or CT scans for other reasons and these tumors are found incidentally. Cystic neoplasms are subdivided into serous, mucinous and intraductal papillary mucinous neoplasms. These lesions are described separately on this website but a few generalities pertain to all. The most important aspect of these lesions is to recognize them. They must be differentiated from benign pancreatic cysts as the treatment is distinctly different. Differentiation of benign cysts from cystic neoplasms of the pancreas can usually be made by a good history and physical exam by a physician familiar with these disorders. If a cystic neoplasm is suspected and the patient is symptomatic (abdominal pain), surgical ...
Robot-Assisted Laparoscopic Vesiculectomy for Large Seminal Vesicle Cystadenoma: A Case Report and Review of the Literature. ( 25862321 ) ...
Biliary cystadenomas are uncommon benign cystic neoplasms of the liver. Epidemiology Biliary cystadenomas occur predominantly in middle-aged patients and are more common in women 1. Clinical presentation The clinical presentation of biliary c...
Endoscopic ultrasound will be used to locate and assess the pancreatic cyst. The fluid contents will be aspirated using a fine needle and sent for tumor marker analysis and cytology. With the needle maintained in the same position, 99% ethanol will be injected into the cyst. After 3-5 minutes of lavage, the entire volume of fluid will be removed from the cyst. The same volume of paclitaxel minus 1 mL [3mg/ml diluted in normal saline from original concentration of 6mg/mL] will be injected and left in the cyst. The needle is then retracted and the procedure completed. Patients will receive oral prophylactic antibiotics for 5 days after the procedure. Clinical follow up with MRI imaging with be done at 6, 12, 18, and 24 months. For those with a persistent cyst at 12 months, a repeat EUS FNI procedure will be done ...
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Cytological examination of breast lesions is frequently used in Portugal, but its diagnostic and prognostic values are controversial. The objective of this study was to evaluate the accuracy of cytological exam in the diagnosis of mammary lesions, compared to the histopathologic exam. We consulted 30 aspiration cytologies of canine mammary lesions and 15 of feline mammary lesions, which were gathered between the years 2011 and 2017 from the archives of the CEDIVET laboratory. Cytology diagnosed 12 benign lesions, 26 of border-line malignancy and 7 malignant. The histopathologic exam diagnosed 25 benign lesions and 20 malignant. The specific value, sensibility value, VPP and VPN were calculated for all cases. These parameters were then calculated exclluding the borderline malignancy diagnostics. Thus, sensivity increased from 39% to 71% in canine females and from 14% to 50% in female cats. The specificity was always 100% in the canine specie and in the feline it suffered a drop from 88% to 67%. ...
Cytological examination of breast lesions is frequently used in Portugal, but its diagnostic and prognostic values are controversial. The objective of this study was to evaluate the accuracy of cytological exam in the diagnosis of mammary lesions, compared to the histopathologic exam. We consulted 30 aspiration cytologies of canine mammary lesions and 15 of feline mammary lesions, which were gathered between the years 2011 and 2017 from the archives of the CEDIVET laboratory. Cytology diagnosed 12 benign lesions, 26 of border-line malignancy and 7 malignant. The histopathologic exam diagnosed 25 benign lesions and 20 malignant. The specific value, sensibility value, VPP and VPN were calculated for all cases. These parameters were then calculated exclluding the borderline malignancy diagnostics. Thus, sensivity increased from 39% to 71% in canine females and from 14% to 50% in female cats. The specificity was always 100% in the canine specie and in the feline it suffered a drop from 88% to 67%. ...
The objective of this project is the development of a 3D biodegradable matrix allowing the graft of autologous ovarian tissue or isolated follicles in patients with impaired fertility following a gonadotoxic treatment. This biofunctional fibrin-based matrix will limit the follicular loss due to post-transplant ischemic stress and will help to induce the formation of an extracellular ovarian-like matrix by promoting cell migration, cell proliferation and vascularization. In addition, a biodegradable textile pocket will also be developed to contain the tissue scaffold and to efficiently suture the graft at the implantation site.. ...
Pancreatic serous cystadenoma, also known as serous cystadenoma of the pancreas and serous microcystic adenoma, a benign tumour of pancreas. It is usually found in the head of the pancreas, and may be associated with von Hippel-Lindau syndrome. In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm), serous cystic neoplasms are almost always entirely benign. There are some exceptions; rare case reports have described isolated malignant serous cystadenocarcinomas. In addition, serous cystic neoplasms slowly grow, and if they grow large enough they can press on adjacent organs and cause symptoms. Pathologists classify serous cystic neoplasms into two broad groups. Those that are benign, that have not spread to other organs, are designated "serous cystadenoma". Serous cystadenomas can be further sub-typed into microcystic, oligocystic (or macrocystic), solid, mixed serous-endocrine neoplasm, and ...
Causes of ovarian serous cystadenoma - What causes an ovarian serous cystadenoma to rupture do I need surgery if rupture? Pressure. The increased pressure and weak wall of the ovary can cause it to rupture - you do not need surgery if it does. You might consider getting it removed before it does though.
Background:Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns of recurrence and treatment variations in a large population of patients, treated at reference centers.Methods:All consecutive patients with primary RPS treated at 6 European and 2 North American institutions between January 2002 and December 2011 were included. Five, 8, and 10-year overall survival (OS) and crude cumulative incidence (CCI) of local recurrence (LR) and distant metastasis (DM) were calculated. Multivariate analyses for OS, CCI of LR, and DM were performed.Results:In all, 1007 patients were included. Median follow-up was 58 months (first and third quartile range 36-90). The 5, 8, and 10-year OS were 67% [95% confidence interval (CI), 63, 70), 56% (95% CI, 52, 61), and 46% (95% CI, 40, 53). The 5, 8, and 10-year CCI of LR and DM were 25.9 (95% CI, 23.1, 29.1), 31.3 (95% CI, 27.8, 35.1), 35% (95% CI, 30.5, 40.1), and 21% (95% ...
In the current study we provide quantitative interrogation of MC and MBOTs using amplicon-based hotspot sequencing. Our re-sequencing efforts confirmed KRAS mutations to be the most frequent molecular alteration amongst mucinous tumors, appearing more common in borderline malignancies over carcinomas (92.3 % versus 64.9 %, respectively; Fisher exact p = 0.0157). These values reflect what was previously reported [13]; however, improved sensitivity through the use of next generation sequencing identified KRAS mutations in three cases previously believed to be wild type (one MBOT and two MC). We further added to the complement of known RAS-activating mutations in observing mutations in BRAF (two MC), as well as previously unreported potentially RAS-activating alterations in FGFR2, ERBB2, and STK11, each affecting a single carcinoma. As noted above, inactivating mutation of STK11 could be considered an alternative mechanism to RAS-activation outside of typical KRAS/BRAF mutations [36, 37], an ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
Cystic tumors of the pancreas today are diagnosed more frequently in clinical practice, mainly due to an increased use of the modern advanced imaging modalities.. Bland cysts of the pancreas most often develop after chronic or acute inflammation of the pancreas. However, the current knowledge concerning the development of cystic neoplasias of the pancreas is still rudimentary.. Histopathologically, 90% of pancreatic cystic neoplasias are represented by four types: serous microcystic (SCN), mucinous cystic (MCN), intraductal papillary mucinous (IPMN) and solid pseudopapillary (SPN) neoplasias. Surgical treatment of these lesions can be highly challenging and occasionally demands complex surgical approaches that should be put in the hands of skilled pancreatic surgeons in experienced high-volume centers.. While some of the described cystic tumors are harmless, such as SCNs of the pancreas, others such as IPMN and MCN harbor relevant malignant potential. The differential diagnosis of these lesions ...
A cystic tumor of the ovary either nonneoplastic (follicle, lutein, germinal inclusion, or endometrial) or neoplastic; either benign (pseudomucinous or serous cystadenoma, or dermid) or malignant (carcinoma ...
Cystadenoma most often occurs in middle-aged women. However, cystadenocarcinoma equally affects both men and women. Most patients are asymptomatic or have vague abdominal complaints of bloating, nause... more
Histologic assessment of the excised cyst wall should be routinely undertaken to identify the presence of an unsuspected neoplasm, such as cystadenoma. In simple cysts, histology of the cyst wall gene... more
In the pelvis there is a large sepated cystic mass lesion seen occupying most of the pelvis and lower abdomen. This measures 14 x 9.3 x 11.1cm in size and demonstrates septation and predominantly fluid density. At its right posterolateral wall therte is also a slightly denser and minimal contrast enhancing mural nodule present. This measures approximately 17mm in size. I note the history of possible hydrosalpinx but I feel this lesion is too rounded and septated in appearance and likely represents a cystic tumour of the ovary ? right ovarian origin rather than hydrosalpinx. Suggest correlation with clinical history. I note there was a question raised previously with possible oophorectomy in the CT report in 2008. In understand the patient is to have a second gynaecological opinion tomorrow. ...
Yeast, Stem Cells, Cobalt, Asparagine, Glutamine, Patients, Neoplasms, Pancreas, Biomarkers, Cyst, Mutations, Tumor, and Mutation
Like OCIAD1, OCIAD2 is a cancer-related protein and its expression level increases during the course of malignant progression and is thought to be a very useful marker for evaluating the malignancy of ovarian mucinous tumors ...