Mucinous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. It can occur in the breast as well as in the ovary. Tumors are normally multilocular with various smooth, thin walled cysts. Within the cysts is found a haemorrhagic or cellular debris. Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, Takubo K (August 2003). "Mucinous cystadenocarcinoma of the breast: a case report and review of the literature". Arch. Pathol. Lab. Med. 127 (8): 1031-3. doi:10.1043/1543-2165(2003) ...
The etiology and biological behavior of PRMCs are still unclear; however, some hypotheses have been proposed to explain the genesis of these tumors as follows: (1) heterotopic ovarian tissue [3, 11, 47], (2) monodermal variant of teratomas [22, 48], (3) intestinal duplication [49], and (4) coelomic metaplasia [4, 8, 12, 50]. In our case, ovarian-like stroma was histopathologically found in the tumor, although no definitive evidence of ovarian tissue was observed, which was also supported by the results of an immunohistochemical examination of the estrogen and progesterone receptors. These findings exclude the hypothesis of heterotopic ovarian tissue. In addition, the hypotheses of teratoma and intestinal duplication can also be excluded because of the lack of structures of teratoma or well-developed intestinal mucosa and smooth muscle. The fourth hypothesis, which is most well-described in the previous literature, is that PMRCs occur from invaginations of the peritoneal epithelium during ...
Pancreatic cystadenocarcinoma is an extremely rare neoplasm in pregnancy. To our knowledge, there have been 2 published cases of pancreatic mucinous cystadenocarcinoma (PMC) during pregnancy in the literature; one of which was reported to have ruptur
Pancreatic mucinous cystic neoplasm, also mucinous cystic neoplasm of the pancreas and mucinous cystic tumour, is a grouping of cystic neoplasms that arise from the pancreas. They may be benign, malignant or in between. The prognosis of this set of tumours is highly variable and dependent on the specific sub-classification (benign, borderline, malignant). Mucinous cystic neoplasms of the pancreas are defined by the World Health Organization (WHO) as cystic epithelial neoplasms that occur almost exclusively in women; do not communicate with the pancreatic ductal system and which are composed of columnar, mucin-producing epithelium, supported by ovarian-type stroma. This means that these tumors make mucin (a thick sticky fluid), they do not arise in the larger pancreatic ducts, and they have a peculiar supporting stroma (or support structure). Mucinous cystic neoplasms of the pancreas classified as benign, borderline, or malignant, based on histomorphological features which predict their ...
Effectiveness of 2nd line chemotherapy in the treatment of ovarian cancer using gemcitabine- or ifosfamideand etoposide-based protocols - experience of the Depa
To evaluate the impact on PFS of an anti-hormonal maintenance therapy after 1st line chemotherapy at the discretion of the investigator (e.g. taxanes,
This is my first post and I am hoping someone might be able to help. Can I first just say how helpful it has been over the last few months reading everyones comments and knowing what to expect. I ...
Anderson Cancer Center between January 1992 and December 2004 and who did not meet any of the following exclusion criteria: stage III or IV ovarian cancer, appendectomy as part of a second-look procedure or secondary tumor-reductive surgery, primary appendiceal cancer, primary gastrointestinal malignancy with metastasis to the appendix, incomplete clinicopathologic data, appendicitis as a preoperative diagnosis, primary fallopian tube cancer, primary peritoneal cancer, or documented dual primary tumors ...
Semantic Scholar extracted view of EDUCATION AND IMAGING. Hepatobiliary and Pancreatic: Long-term survival of serous cystadenocarcinoma of the pancreas with synchronous liver metastases after aggressive surgical resection. by Hayato Sasaki et al.
Some authors believe the term microcystic serous adenoma is too limiting and that a macrocystic variant of the same neoplasm exists; the term serous cystadenoma is thus used for both morphologic variants.Nevertheless, the term macrocystic serous tumor is useful; these tumors are often misdiagnosed as either mucinous cystic neoplasms or pseudocysts. In fact, some tumors are misclassified even with intraoperative frozen section. Serum tumor markers with macrocystic serous tumors tend to be normal, although CA 125 and CA 19-9 are elevated in the cyst fluid in some of these tumors. The macrocystic variant of serous adenoma consists of a small uni- or bilocular cyst containing a thin wall without any mural nodules; these are indistinguishable from mucinous cystic tumors ...
A 71-year-old woman was referred to our institution for further investigation of epigastric pain. The patient had been detected to have a multilocular cyst in the medial segment of the liver measuring 69 mm in diameter at another hospital 2 years ago, and the diameter of the cyst had increased to 90 mm. Although the cyst had gradually increased in size, there was no evidence of mural nodules. As we were concerned about the malignant potential of the lesion, a left hepatic segmentectomy was performed. Pathologically, the cyst was lined by columnar and cuboidal epithelium with low-grade atypia. The epithelium covered an ovarian-like stroma, and the diagnosis was mucinous cystic neoplasm of the liver (MCN-L) with low-grade intraepithelial neoplasia. MCN-L is a rare disease and its characteristics are still poorly understood. MCN-L occurs at a lower frequency as compared to the counterpart of MCN of the pancreas, further investigations are necessary to clarify the biological malignancy of MCN-L.
We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The thing is you may have more than one cysts and though 1 had ruptured, it can cause others to be inflamed or prone to break - like a chain reaction.. It seems that in patients whom follow a treatment against infertility with womanly hormones like FSH the risk of functional cysts to form is very high. Macrophages killed the cysts by phagocytosis, whereas neutrophils wiped out cysts through the secretion of MPO.. Individuals were followed up 24 instances of being pregnant 15 instances of infertility, pregnancy level 62. 5%; 5 instances confirmed recurrence, the recurrence rate was 5. 3%. Conclusions Laparoscopic surgical injury, quicker recovery, pelvic obvious vision, releasable pelvic adhesions in individuals with increased being pregnant rate of infertility, ovarian endometriosis must be used since the preferred way of cyst. ...
Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4-140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCNs related mortality was 0.1% (n=1). ...
MeSH-minor] Adenocarcinoma, Mucinous / drug therapy. Adenocarcinoma, Mucinous / metabolism. Adenocarcinoma, Mucinous / pathology. Benzamides. Carboplatin / administration & dosage. Carcinoma, Papillary / drug therapy. Carcinoma, Papillary / metabolism. Carcinoma, Papillary / pathology. Cystadenocarcinoma, Serous / drug therapy. Cystadenocarcinoma, Serous / metabolism. Cystadenocarcinoma, Serous / pathology. Endometrial Neoplasms / drug therapy. Endometrial Neoplasms / metabolism. Endometrial Neoplasms / pathology. Female. Humans. Imatinib Mesylate. Immunoenzyme Techniques. Paclitaxel / administration & dosage. Piperazines / administration & dosage. Proto-Oncogene Proteins c-abl / genetics. Proto-Oncogene Proteins c-abl / metabolism. Proto-Oncogene Proteins c-kit / genetics. Proto-Oncogene Proteins c-kit / metabolism. Pyrimidines / administration & dosage. RNA, Messenger / genetics. RNA, Messenger / metabolism. RNA, Neoplasm / genetics. RNA, Neoplasm / metabolism. Tissue Array Analysis. Tumor ...
Associations between reproductive factors and risk of ovarian cancer were examined in a prospective study of 60,565 women in Norway. A total of 445 women were diagnosed as having ovarian cancer during follow-up, from 1961 through 1980. The highest risk was observed among nulliparous women, and the risk decreased significantly with increasing parity. The estimated odds ratio for women with 5 or more births compared with one birth was 0.46, after adjustment for age, urban/rural place of residence and occupational class. Neither age at first or last birth, nor age at menarche or menopause, nor marital status, showed significant associations with ovarian cancer risk after adjustment for parity. The apparent protective effect of high parity was observed for epithelial as well as non-epithelial cancers, and for the separate histological types of epithelial cancer except mucinous cystadenocarcinomas.
An ideal diagnostic approach would allow for the resection of only those lesions with present or near-future risk of malignancy, while excluding from surgery those individuals with either benign lesions or a prohibitive operative risk, thus minimizing the potential occurrence of mortality and morbidity associated with the surgical treatment of these cystic lesions. Recent advancements in imaging by CT, MRI, and endoscopic ultrasonography (EUS), linked with refinements in the pathological understanding of cystic neoplasms of the pancreas have furthered this effort. History and clinical criteria, such as age, gender, presence of symptoms, location of the neoplasm within the pancreas, as well as, morphology by cross-sectional imaging and cyst fluid analysis by EUS with fine-needle aspiration (EUS-FNA), all may play a role in the diagnosis of pancreatic cystic neoplasms and assessment of the need for resection. A recent analysis using decision analysis with Markov modeling has indicated that for ...
Low-grade cribriform cystadenocarcinoma of salivary glands Definition : Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described (...)
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patients clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician ...
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have been recently diagnosed at hospital or in private-sector for the following diseases: Local or metastatic cancer diagnosed less than 6 month (breast cancer-hormone sensitive- in first line chemotherapy treatment, hormone-sensitive prostate cancer or in metastatic recurrence after 3 years of remission, considered as a new case, colorectal cancer in first line chemotherapy treatment), a neuro-degenerative disease (Parkinson disease diagnosed less than 7 years, Alzheimer disease and similar diseases diagnosed less than 12 months and /or with a Mini Mental State Examination (MMSE ...
Despite being implicated in multiple types of human epithelia-origin cancer, laminin-binding (LB) integrins (e.g., α3α1 and α6β4) have rarely been investigated for their roles in human ovarian tumors. More recently, we and others have shown that CD151, a member of the tetraspanin family, not only forms tight surface complexes with these adhesion receptors, but also mediates the malignancy of human carcinomas largely in a LB integrin-dependent manner. Here we report our studies on the role of CD151 in human ovarian cancer. Initially, we stained human ovarian tumor tissue microarrays with CD151-specific antibody. Our data showed that the majority of ovarian tumors exhibited a reduced expression of CD151 protein, compared to the fallopian tube, implying a putative suppressing role of this tetraspanin in ovarian cancer. With this hint we next evaluated the impact of CD151 ablation on the behaviors and proliferation of cultured human ovarian cancer cells. While CD151 removal had a minimal impact ...
Metastatic neoplasms are secondary ovarian tumors. The main sources of metastasis are carcinomas of the stomach, intestines, breast and uterus.
From one of the patients included, the original x-ray coronary angiogram could not be traced by the referring cardiologist. Furthermore, the two independent observers reviewing all x-ray coronary angiograms both judged that the coronary angiogram of 1 patient could not be analyzed because it was an incomplete study. Of the remaining 36 films, observer A judged 19 angiograms to show normal coronary anatomy and 17 to show anomalously arising coronary arteries, whereas observer B judged 20 to show normal and 16 to show anomalous anatomy. Interobserver agreement for differentiating anomalous from normal coronary anatomy was 97%. In 5 of the patients, there was difference in opinion about the site of origin of an (anomalous) artery. In 4 of these 5 patients, the disagreement consisted of one of the observers having labeled the origin of an anomalous artery as "unclear," whereas the other had specified an anomalous origin (in 3 patients, an anomalous origin of the RCA from or from above the left sinus ...
TY - JOUR. T1 - Primary pancreatic cystic neoplasms revisited. Part I. T2 - Serous cystic neoplasms. AU - Sakorafas, George H.. AU - Smyrniotis, Vasileios. AU - Reid-Lombardo, Kaye M.. AU - Sarr, Michael G.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Primary pancreatic cystic neoplasms have been recognized increasingly during the two recent decades and include mainly serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. Serous cystic neoplasms represent about 30% of all cystic neoplasms of the pancreas and are characterized by their microcystic appearance (on imaging, macroscopically, and microscopically) and their benign biologic behavior. Modern diagnostic methodology allows the preoperative diagnosis with an acceptable accuracy. Currently, indications for resection of serous cystic neoplasms of the pancreas include the presence of symptoms, size , 4 cm (because these large neoplasms have a more rapid growth rate and probably will soon become symptomatic), ...
A close-up of the smooth appendiceal luminal surface is shown. Differential diagnosis included mucocele, mucinous cystadenoma, mucinous cystadenocarcinoma and less likely, carcinoid ...
The only method you can actually tell how big an ovarian cyst is by going into your physician for an ultrasound. However, kids arent spared of Dermoid cysts - often children get them near to the eyebrows spectrum of ankle aspect and so they feel like rubberized. Many different steps are there in treating Ovarian cyst patients in respect to their person condition. Mucinous cystadenocarcinoma is usually unilateral and involve the existence of irregular dense septa or solid papillary projections which can be usually recognized within cysts ( Fig.. There are generally only a couple of options for treatment; one is surgical removal of the cysts, and the additional is body hormone treatment by means of birth control supplements. She was told the fact that ultrasound search within will be repeated in a few a few months time; in the event the cysts develop larger, they need to be eliminated by medical procedures.. However , a functional cyst may interrupt your menstrual cycle simply by preventing ...
Ovarian malignancy was found to be associated with ovarian, laryngeal, breast, endometrial, liver, and colon carcinoma, as well as myeloma; epithelial ovarian malignancy was found to be associated with ovarian, endometrial, and skin malignancies and with melanoma and myeloma; papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and endometrioid carcinoma was found to be associated with endometrial, ovarian, and prostate malignancies and with melanoma. For younger women (ages 40-45 years) whose mothers were affected with endometrial malignancies, the risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...
Cystic neoplasms of the pancreas represent about 10% of all cysts of the pancreas and ~1% of all pancreatic neoplasms. Much has been learned about the natural history and management of these tumors in the past decade. We are finding more of these lesions than in years past since so many patients receive ultrasounds or CT scans for other reasons and these tumors are found incidentally. Cystic neoplasms are subdivided into serous, mucinous and intraductal papillary mucinous neoplasms. These lesions are described separately on this website but a few generalities pertain to all. The most important aspect of these lesions is to recognize them. They must be differentiated from benign pancreatic cysts as the treatment is distinctly different. Differentiation of benign cysts from cystic neoplasms of the pancreas can usually be made by a good history and physical exam by a physician familiar with these disorders. If a cystic neoplasm is suspected and the patient is symptomatic (abdominal pain), surgical ...
Answer: Mucinous cystic neoplasm. Histology: This unusual neoplasm is has two distinct components. The stroma has the appearance of ovarian stroma, and indeed the stromal cells immunolabeled for estrogen and progesterone receptors. The second component is composed of epithelial cells. These cells are mostly cuboidal and occasionally have a "hobnail" appearance.. Discussion: Mucinous cystic neoplasms of the pancreas occur in women more frequently than they do in men, and mucinous cystic neoplasms have a distinctive "ovarian-type" of stroma. The neoplasm presented arose in a woman and it has ovarian stroma. One might expect that it is a classical mucinous cystic neoplasm, but two things are peculiar about this case. First, the epithelial cells do not form large cysts. Second, the epithelial cells are not columnar mucin-producing cells. Instead, they are mostly cuboidal and somewhat hob-nailed in appearance. This histologic appearance is almost identical to the mixed epithelial and stromal tumor ...
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed ...
This 4 arm study will assess the optimal starting dose of Mircera in the treatment of anemia in patients with non-small cell lung cancer receiving first
See also pancreatic anomalies simple mucinous cyst Open references A Revised Classification System and Recommendations From the Baltimore (...)
Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate into a frank cancer. Most patients with these tumors are in their 5th and 6th decade and it is more common in women. Most of these tumors occur in the body and tail of the pancreas. As with serous cystadenomas they can usually be definitely diagnosed with modern diagnostic testing. When small (,3cm) and asymptomatic, most experts feel these lesions can be safely observed provided there is close surveillance with CT scans. If the lesion is ,3cm, causing symptoms or obstructing the pancreatic duct they should be surgically excised. Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed.. ...
A 40-year-old Japanese woman, who previously had undergone choledocho-jejunostomy in childhood for a congenital choledocal cyst, presented with right-sided chest pain. Computed tomography and ultrasonography demonstrated a right pleural effusion and a 10-cm unilocular hepatic cystic lesion with no solid component. These findings suggested a non-neoplastic cyst or cystadenoma. However, intracystic fluid aspirated had high concentrations of carbohydrate antigen 19-9 and carcinoembryonic antigen. Cytology of the pleural effusion demonstrated malignant cells. During exploratory laparo- and thoracotomy, a hepatic cystadenocarcinoma with invasion of the diaphragm and pleural dissemination was discovered. This case demonstrates that malignancy should be ruled out when a patient with an intrahepatic unilocular cystic lesion presents with atypical symptoms and findings, such as chest pain, pleural effusion, and high serum concentration of tumor markers. We believe that intrahepatic cystic lesions should be
Eighty five ovarian epithelial and non-epithelial tumours were studied by peroxidase histochemical staining for their reactivity with six monoclonal human milk fat globule (HMFG) antibodies, peanut agglutinin (PNA) lectin, and a monoclonal cytokeratin antibody. HMFG IIIC12 and cytokeratin antibodies distinguished epithelial from non-epithelial tumours. The staining patterns of mucinous and serous tumours were essentially different from each other; poorly differentiated anaplastic carcinomas showed similar antigenic content to that of the serous cystadenocarcinomas. Furthermore, staining with PNA lectin and HMFG antibodies was useful in distinguishing clear cell carcinomas from other malignant epithelial tumours of the ovary.. ...
Endoscopic ultrasound will be used to locate and assess the pancreatic cyst. The fluid contents will be aspirated using a fine needle and sent for tumor marker analysis and cytology. With the needle maintained in the same position, 99% ethanol will be injected into the cyst. After 3-5 minutes of lavage, the entire volume of fluid will be removed from the cyst. The same volume of paclitaxel minus 1 mL [3mg/ml diluted in normal saline from original concentration of 6mg/mL] will be injected and left in the cyst. The needle is then retracted and the procedure completed. Patients will receive oral prophylactic antibiotics for 5 days after the procedure. Clinical follow up with MRI imaging with be done at 6, 12, 18, and 24 months. For those with a persistent cyst at 12 months, a repeat EUS FNI procedure will be done ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
This trial will evaluate the efficacy and safety of oral vinorelbine-cisplatin (OV-P) in first line advanced triple negative breast cancer (ATNBC).
Patients were administered FOLFIRI every 2 weeks in one course. FOLFIRI:CPT-11 150 mg per square meter on day1 with l-LV 200 mg per square meter administered as a 2-hour infusion before 5-FU 400 mg per square meter administered as an intravenous bolus injection, and 5-FU 2400 mg per square meter as a 46-hour infusion immediately after 5-FU bolus injection on day1 in 2 weeks ...
Purpose: Pancreatic cysts are common and pose diagnostic and management challenges. Pancreatic cyst fluid markers have the potential to aid in the management of cysts with concerning imaging findings. Our aim was to evaluate cyst fluid methylated DNA markers for their accuracy for predicting the histologic grade of neoplastic pancreatic cysts. Experimental Design: Pancreatic cyst fluid samples from 183 patients (29 discovery, 154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4 and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP). Methylated DNA levels were evaluated for their accuracy at predicting the grade of dysplasia of the pancreatic cyst. Results: All six markers evaluated in the validation set could accurately distinguish high-risk cystic neoplasms (with high-grade dysplasia and/or associated invasive cancer) from low-risk cysts (lower grades of dysplasia) with accuracies from 79.8 ...
An Unusual Association of Lung and Ovarian Malignancy in a Young Nonsmoker Female: 10.4018/ijudh.2012100104: Lung cancer in a 25-year-old nonsmoker female is extremely rare. Ovarian malignancy in this age group is also infrequent and if occurs, is usually of germ
Cystadenoma most often occurs in middle-aged women. However, cystadenocarcinoma equally affects both men and women. Most patients are asymptomatic or have vague abdominal complaints of bloating, nause... more
If you have a pancreatic cyst, it is important that you get a timely and accurate diagnosis to confirm whether or not your cyst contains cancer cells so that prompt treatment can occur.
Pancreatic cysts are small, fluid-filled growths in the pancreas that can be cancerous or noncancerous. They sometimes grow as a result of pancreatitis, but most develop for no apparent reason. Learn about your options for having pancreatic cysts treated or watched for signs of change over time.
Anne Marie Lennon, MD, PhD, director of the Pancreatic Cyst Clinic discusses the prevalence and optimal management of pancreatic cysts.
Specific preoperative diagnosis of pancreatic cystic neoplasms by CT alone is substantially inaccurate. Complementary tests such as EUS-FNA with fluid analysis and ERCP should be recommended to improve diagnosis especially if nonoperative treatment is planned.
TAPUR stands for Targeted Agent and Profiling Utilization Registry - it is a beacon of hope for cancer patients seeking treatment when first line chemotherapy...
Cysts are responsible for secreting fluid into the cysts, that can be harmful. The Treatment For Pancreatic Cysts In Delhi available for the sufferer.
When it comes to pancreatic cysts, expert evaluation is vital to accurately diagnose the nature of the cyst, and then determine the best course of treatment.