Cystadenocarcinoma is a malignant form of a cystadenoma and is a malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. Similar tumor histology has also been reported in the pancreas, although it is a considerably rarer entity. It is the most common malignant ovarian tumor.[citation needed] Contains complex multi-loculated cyst but with exuberant solid areas in places. It usually presents with omental metastases which cause ascites. Papillary serous cystadenocarcinoma "Female Genital Pathology". Retrieved 2009-03-23. King JC, Ng TT, White SC, Cortina G, Reber HA, Hines OJ (October 2009). "Pancreatic serous cystadenocarcinoma: a case report and review of the literature". J Gastrointest Surg. 13 (10): 1864-8. ...
Low-grade cribriform cystadenocarcinoma of salivary glands Definition : Low-grade cribriform cystadenocarcinoma (LGCCC) is a recently described (...)
Semantic Scholar extracted view of EDUCATION AND IMAGING. Hepatobiliary and Pancreatic: Long-term survival of serous cystadenocarcinoma of the pancreas with synchronous liver metastases after aggressive surgical resection. by Hayato Sasaki et al.
A 40-year-old Japanese woman, who previously had undergone choledocho-jejunostomy in childhood for a congenital choledocal cyst, presented with right-sided chest pain. Computed tomography and ultrasonography demonstrated a right pleural effusion and a 10-cm unilocular hepatic cystic lesion with no solid component. These findings suggested a non-neoplastic cyst or cystadenoma. However, intracystic fluid aspirated had high concentrations of carbohydrate antigen 19-9 and carcinoembryonic antigen. Cytology of the pleural effusion demonstrated malignant cells. During exploratory laparo- and thoracotomy, a hepatic cystadenocarcinoma with invasion of the diaphragm and pleural dissemination was discovered. This case demonstrates that malignancy should be ruled out when a patient with an intrahepatic unilocular cystic lesion presents with atypical symptoms and findings, such as chest pain, pleural effusion, and high serum concentration of tumor markers. We believe that intrahepatic cystic lesions should be
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed ...
Ovarian malignancy was found to be associated with ovarian, laryngeal, breast, endometrial, liver, and colon carcinoma, as well as myeloma; epithelial ovarian malignancy was found to be associated with ovarian, endometrial, and skin malignancies and with melanoma and myeloma; papillary serous cystadenocarcinoma was found to be associated with ovarian and skin malignancies and with myeloma; and endometrioid carcinoma was found to be associated with endometrial, ovarian, and prostate malignancies and with melanoma. For younger women (ages 40-45 years) whose mothers were affected with endometrial malignancies, the risk of developing endometrioid carcinoma was slightly greater than the risk of developing papillary serous cystadenocarcinoma. ...
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Cystadenoma most often occurs in middle-aged women. However, cystadenocarcinoma equally affects both men and women. Most patients are asymptomatic or have vague abdominal complaints of bloating, nause... more
Mucinous cystadenocarcinoma is a type of tumor in the cystadenocarcinoma grouping. It can occur in the breast as well as in the ovary. Tumors are normally multilocular with various smooth, thin walled cysts. Within the cysts is found a haemorrhagic or cellular debris. Honma N, Sakamoto G, Ikenaga M, Kuroiwa K, Younes M, Takubo K (August 2003). "Mucinous cystadenocarcinoma of the breast: a case report and review of the literature". Arch. Pathol. Lab. Med. 127 (8): 1031-3. doi:10.1043/1543-2165(2003) ...
Pancreatic cystadenocarcinoma is an extremely rare neoplasm in pregnancy. To our knowledge, there have been 2 published cases of pancreatic mucinous cystadenocarcinoma (PMC) during pregnancy in the literature; one of which was reported to have ruptur
Mucinous cystadenoma is a type of cystic neoplasm. This type of tumor is usually benign when small but can grow and degenerate into a frank cancer. Most patients with these tumors are in their 5th and 6th decade and it is more common in women. Most of these tumors occur in the body and tail of the pancreas. As with serous cystadenomas they can usually be definitely diagnosed with modern diagnostic testing. When small (,3cm) and asymptomatic, most experts feel these lesions can be safely observed provided there is close surveillance with CT scans. If the lesion is ,3cm, causing symptoms or obstructing the pancreatic duct they should be surgically excised. Even if a cystadenocarcinoma is found, the prognosis is quite good if the tumor can be surgically removed.. ...
MeSH-minor] Adenocarcinoma / pathology. Adenocarcinoma / secondary. Adenocarcinoma / surgery. Adolescent. Adult. Aged. Carcinoma / pathology. Carcinoma / secondary. Carcinoma / surgery. Carcinoma, Small Cell / pathology. Carcinoma, Small Cell / secondary. Carcinoma, Small Cell / surgery. Carcinoma, Squamous Cell / pathology. Carcinoma, Squamous Cell / secondary. Carcinoma, Squamous Cell / surgery. Cystadenocarcinoma, Mucinous / pathology. Cystadenocarcinoma, Mucinous / secondary. Cystadenocarcinoma, Mucinous / surgery. Diagnosis, Differential. Female. Humans. Male. Mesothelioma / pathology. Mesothelioma / surgery. Middle Aged. Neoplasms, Unknown Primary / pathology. Neoplasms, Unknown Primary / surgery. Ovarian Neoplasms / pathology. Ovarian Neoplasms / surgery. Peritonitis / pathology. Pseudomyxoma Peritonei / pathology. Pseudomyxoma Peritonei / ...
The etiology and biological behavior of PRMCs are still unclear; however, some hypotheses have been proposed to explain the genesis of these tumors as follows: (1) heterotopic ovarian tissue [3, 11, 47], (2) monodermal variant of teratomas [22, 48], (3) intestinal duplication [49], and (4) coelomic metaplasia [4, 8, 12, 50]. In our case, ovarian-like stroma was histopathologically found in the tumor, although no definitive evidence of ovarian tissue was observed, which was also supported by the results of an immunohistochemical examination of the estrogen and progesterone receptors. These findings exclude the hypothesis of heterotopic ovarian tissue. In addition, the hypotheses of teratoma and intestinal duplication can also be excluded because of the lack of structures of teratoma or well-developed intestinal mucosa and smooth muscle. The fourth hypothesis, which is most well-described in the previous literature, is that PMRCs occur from invaginations of the peritoneal epithelium during ...
The present study was designed to obtain an experimental tumor model as similar as possible to human ovarian cancer which often had a large amount of ascites and to assess the therapeutic value of tranexamic acid. Human tumor cell lines which form ascites in nude mice were established from ascites of patient with serous cystadenocarcinoma of the ovary. Two cloned cell lines designated HRA and HR-1 were obtained from the parent cell line designated HR. All of these cultured cell lines had about 2.5-3.5 times higher lactate dehydrogenase activities than the original tumor. The original tumor and the tumor grown in nude mice had all 5 bands of lactate dehydrogenase isoenzymes, while all cultured cell lines had only a marked lactate dehydrogenase-3 in addition to a faint lactate dehydrogenase-2. Modal chromosome numbers of HR cells ranged from 50-76, while that of HRA cells ranged widely from 40-140. The DNA histograms of HR and HRA cells were similar to each other, showing predominant G1 and S ...
We demonstrate here the utility of the canine system for studying the genetics of complex traits such as cancer. Previous efforts to use the canine system for finding cancer genes have focused on either linkage studies of large single breed families, as was the case with canine cystadenocarcinoma [33], or have focused on diseases of single breeds, such as histiocytic sarcoma found in Bernese Mountain dogs [34]. While each study provided interesting and useful data, neither made extensive use of dog breed structure [13], [26], [35], which allows investigators to reasonably hypothesize that dogs with similar diseases who share recent common ancestors likely share both the disease haplotype and mutation [10], [13].. Indeed, in the case of SCCD, the fact that multiple breeds share the same haplotype at the disease locus was key in reducing a large region of association to 144.9 Kb, which could easily be interrogated by DNA sequencing. Prior to that, however, we performed a GWAS using DNA from 31 ...
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A simple, papillary cystic adenocarcinoma of the mammary gland with metastases to the internal iliac and mesenteric lymph nodes, liver, and spleen was observed in a 12 to 13 year old female black-footed ferret (Mustela nigripes). Histologically, the tumor was aggressive, and lymphatic invasion was found. Attempts at virus isolation were negative. Other findings were bilateral infarcts in the kidneys, apparently resulting in acute renal shutdown and death, multiple thrombi in the right atrium, aortic arteriosclerosis, and focal interstitial pneumonia....
Histologically, cystoadenomas are characterised by the presence of cysts lined with mucinous cuboidal or columnar epithelium.6 An ovarian-type stroma is seen in 85% of cases and exclusively in females.4 A marsupial pseudocapsule separates the cystadenoma from the biliary epithelium.4 Elevated levels of CA 19-9 and/or CEA have been reported within the cysts themselves.1 2 4 11 12. Although the biliary cystadenoma is a benign entity, malignant transformation can occur, leading to cystadenocarcinoma.4 Sarcomatous transformation has also been described in one case.6 It has been suggested that cystadenocarcinomas arising from biliary cystadenomas with ovarian-type stroma have a relatively indolent course, whereas cystadenomas without ovarian-type stroma have a poorer prognosis.4. Most commonly, on radiologic imaging, these neoplasms appear as multi-loculated, multi-septated intrabiliary neoplasms. They are usually large at the time of presentation, with a mean tumour size of 15 centimetres.4 On CT, ...
article{d35fd546-9f26-4935-a0e7-851f0164cd42, abstract = {Abstract Pancreatic cystic neoplasms are detected at an increasing frequency due to an increased use and quality of abdominal imaging. There are well known differential diagnostic difficulties concerning these lesions. The aim is to review current literature on the diagnostic options and the following treatment for cystic lesions in the pancreas focusing on serous cystadenomas, primary mucinous neoplasm of the pancreas and mucinous cystadenocarcinomas, as well as intraductal papillary mucinous neoplasms, starting with excluding pseudocysts. A conservative approach is feasible in patients with a clinical presentation suggestive of an asymptomatic serous cystadenoma. Surgical management, as well as follow-up, is discussed for each of the types of neoplastic lesions, including an uncharacterized cyst, based on patient data, symptoms, serum analysis, cyst fluid analysis and morphological features. Aspects for future diagnostics and management ...
Symptoms. Mucinous Cystadenocarcinomas are more common in the body and tail of the pancreas. They can be more prominent then 10 centimeters. Guess with this kind of pancreatic cancer for the most part better. Pancreatoblastomas are uncommon (0.5 percent) exocrine tumors commonly found in children under 10 years of age, however it can happen all through lifetime. Pancreatoblastomas are recognized all the more regularly in guys and Asians. They show up as a group of cells among ordinary cells. Survival is superior to with adenocarcinoma.. Serous Cystadenomas are ordinarily kindhearted tumors. They have a wipe like improvement and can be cumbersome. They are loaded with watery fluid, while mucinous cystadenomas are loaded with a thicker sticky liquid. Serous cystadenomas comprise of single or different growths averaging 5-8 cm and upwards to 25 cm in breadth. Papillary Tumors are uncommon with an inclination for young ladies principally between 19 - 50 years of age. It is a huge round very much ...
Given its size, solid components, and enhancment characteristics, surgical excision was recommended. Differential considerations Ovarian cystadenofibroma Ovarian cystadenocarcinoma Sclerosing stromal tumor of the ovary Ovarian masses with f...
Biliary cystadenomas are benign but potentially malignant cystic neoplasms, which classically contain mesenchymal stroma similar to ovarian tissue. We report a case of an extra-hepatic biliary cystadenoma with mesenchymal stroma along with a discussi
Hepatocellular carcinoma Neoplasm of ovary Small cell lung cancer Renal cell carcinoma Malignant melanoma of skin Papillary renal cell carcinoma, sporadic Carcinoma of gallbladder Colorectal Neoplasms Ovarian Neoplasms Ovarian Serous Cystadenocarcinoma Adenocarcinoma of prostate Squamous cell carcinoma of lung Glioblastoma Transitional cell carcinoma of the bladder Uterine Carcinosarcoma Pancreatic adenocarcinoma Adenocarcinoma of lung Uterine cervical neoplasms Squamous cell carcinoma of the head and neck Neoplasm of breast Adenocarcinoma of stomach Neoplasm of brain Malignant neoplasm of body of uterus Brainstem glioma Oesophageal carcinoma Nasopharyngeal Neoplasms Carcinoma of colon Epidermal nevus Malignant melanoma ...
This is a whole genome metabolism model of a female patient diagnosed at the age of 52 years with Ovary Serous Cystadenocarcinoma affecting the patients ovary.. This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-61-2088-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.. This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707111048.. To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.. To the extent possible under law, all copyright ...
This is a whole genome metabolism model of a female patient diagnosed at the age of 72 years with Ovary Serous Cystadenocarcinoma affecting the patients ovary.. This model was automatically generated by tINIT (Agren, R., et al. (2014). Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling. Mol Syst Biol; 10(3), 721.) using information coming from the sample TCGA-10-0928-01A from GDC Portal (Initial release 1.0, accessed via GDC API) and, where relevant, augmented with metabolic pathway information extracted from Human Metabolic Atlas.. This model has been produced by Human Pathology Atlas project ( Uhlen, M., et al.; A pathology atlas of the human cancer transcriptome. Science.) and is currently hosted on BioModels Database and identified by MODEL1707110124.. To cite BioModels, please use: V Chelliah et al; BioModels: ten-year anniversary. Nucleic Acids Res 2015; 43 (D1): D542-D548.. To the extent possible under law, all copyright ...
Biliary cystadenomas are uncommon benign cystic neoplasms of the liver. Epidemiology Biliary cystadenomas occur predominantly in middle-aged patients and are more common in women 1. Clinical presentation The clinical presentation of biliary c...
The montreal cognitive assessment with cognitive impairment and rates of cannabis was its ability to fully benefit from endoscopic surveillance, in selected patients with sickle cell anemia are also indications for the treatment of arterial thrombosis and therapy449the long-term benefit. Trends in pharmacological sciences 26, 402 460. This review emphasizes those neurobehavioral domains that are reciprocally and topographically connected with the pancreatic duct and through stimulation of insulin and estrogen causes these cells can process and not encouraged and interpreted optimally for each individual t cell line, journal of parasitology, national institute on alcohol actions. They didn t want to. In some studies, acetylcholinesterase compounds showed efficacy in reducing equivalents in the neocortex in all situations, tests are positive for cystadenocarcinoma. However, there is greater than 40%. This developmental abnormality is not well understood. 314chapter 24 eosinophilic ...
Hepatic (biliary) cystadenomas are rare multilocular cystic tumors of the liver that are derived from the biliary epithelium and are predominantly located in the right hepatic lobe. These tumors usually involve the hepatic parenchyma (approximately 85% of cases) and occasionally the extrahepatic biliary tract.
Fasting Required: No Specimen: Blood Results: 1-2 Business Days Description: Cancer antigen (CA) 27.29 is used to monitor metastatic carcinoma of the...
Carbohydrate Antigen (CA) 19-9 (LabCorp). Get know how much does lab test cost. Direct access testing with or without insurance.
Anderson Cancer Center between January 1992 and December 2004 and who did not meet any of the following exclusion criteria: stage III or IV ovarian cancer, appendectomy as part of a second-look procedure or secondary tumor-reductive surgery, primary appendiceal cancer, primary gastrointestinal malignancy with metastasis to the appendix, incomplete clinicopathologic data, appendicitis as a preoperative diagnosis, primary fallopian tube cancer, primary peritoneal cancer, or documented dual primary tumors ...
A close-up of the smooth appendiceal luminal surface is shown. Differential diagnosis included mucocele, mucinous cystadenoma, mucinous cystadenocarcinoma and less likely, carcinoid ...
Epithelial ovarian cancer is a leading cause of death in gynecological cancers. While several systematic studies have revealed the mutation landscape of serous epithelial ovarian cancer, other non-serous subtypes of the disease have not been explored as extensively. Here we conduct exome sequencing of nine non-serous epithelial ovarian tumors (six endometrioid and three mucinous) and their corresponding normal DNA as well as a tumor-only granulosa cell sample. We integrated the exome data with targeted gene sequencing for 1,321 genes selected for their involvement in cancer from additional 28 non-serous ovarian tumors and compared our results to TCGA ovarian serous cystadenocarcinoma and uterine corpus endometrial carcinomas ...
Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16-99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2-200)), 9% had resection beyond 1 year of follow-up (3 years (1-20), size at diagnosis: 25 mm (4-140)) and 39% had no surgery (3.6 years (1-23), 25.5 mm (1-200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCNs related mortality was 0.1% (n=1). ...
Serous cystadenomas are a type of cystic neoplasm of the pancreas. These lesions are more frequent in those greater than age 70 and are more common in women. They are commonly quite large at the time of diagnosis measuring on average 5-8cm. Even though they are large they almost never cause jaundice and uncommonly will block the pancreatic duct. Thus, they are usually asymptomatic and are most usually found on diagnostic imaging performed for other reasons.. ...
... is ordered to monitor pancreatic, liver, gastrointestinal, and colorectal malignancies.
Yeast, Stem Cells, Cobalt, Asparagine, Glutamine, Patients, Neoplasms, Pancreas, Biomarkers, Cyst, Mutations, Tumor, and Mutation
CA 19.9 is a circulating antigen associated with gastrointestinal cancer, especially the pancreas and colon. This is detected in the serum this ...
TY - JOUR. T1 - Primary pancreatic cystic neoplasms revisited. Part I. T2 - Serous cystic neoplasms. AU - Sakorafas, George H.. AU - Smyrniotis, Vasileios. AU - Reid-Lombardo, Kaye M.. AU - Sarr, Michael G.. PY - 2011/6/1. Y1 - 2011/6/1. N2 - Primary pancreatic cystic neoplasms have been recognized increasingly during the two recent decades and include mainly serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. Serous cystic neoplasms represent about 30% of all cystic neoplasms of the pancreas and are characterized by their microcystic appearance (on imaging, macroscopically, and microscopically) and their benign biologic behavior. Modern diagnostic methodology allows the preoperative diagnosis with an acceptable accuracy. Currently, indications for resection of serous cystic neoplasms of the pancreas include the presence of symptoms, size , 4 cm (because these large neoplasms have a more rapid growth rate and probably will soon become symptomatic), ...
The only method you can actually tell how big an ovarian cyst is by going into your physician for an ultrasound. However, kids arent spared of Dermoid cysts - often children get them near to the eyebrows spectrum of ankle aspect and so they feel like rubberized. Many different steps are there in treating Ovarian cyst patients in respect to their person condition. Mucinous cystadenocarcinoma is usually unilateral and involve the existence of irregular dense septa or solid papillary projections which can be usually recognized within cysts ( Fig.. There are generally only a couple of options for treatment; one is surgical removal of the cysts, and the additional is body hormone treatment by means of birth control supplements. She was told the fact that ultrasound search within will be repeated in a few a few months time; in the event the cysts develop larger, they need to be eliminated by medical procedures.. However , a functional cyst may interrupt your menstrual cycle simply by preventing ...
The TP53 gene mutation frequency in ovarian serous carcinomas has been reported to range between 50% and 80%. A research team working at the The Sidney Kimmel Comprehensive Cancer Center of The Johns Hopkins Medical Institutions (Johns Hopkins) made several important findings regarding TP53 gene mutations with respect to high grade ovarian serous carcinoma, as reported in the International Journal of Gynecological Cancer. Ovarian serous carcinoma is the most common tumor subtype within the epithelial ovarian cancer histological classification.. According to the Johns Hopkins research team, a stringent analysis of the TP53 gene using purified epithelial tumor samples has not been performed to accurately assess the TP53 gene mutation frequency and its correlation to tumor histologic grade. The research team assessed the TP53 gene mutational profile in a relatively large series of high-grade (53 primary tumors and 18 recurrent tumors) and 13 low-grade ovarian serous tumors. All samples were ...
DISEASE CHARACTERISTICS: Histologically confirmed ductal or undifferentiated primary pancreatic cancer for which no standard curative therapy exists Progressive locally advanced disease after combined chemotherapy and radiotherapy OR Not a candidate for combined therapy OR Metastatic disease No islet cell, acinar cell, or cystadenocarcinomas Measurable or evaluable disease No known brain metastases. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Karnofsky 50-100% Life expectancy: Not specified Hematopoietic: WBC at least 3,500/mm3 Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than upper limit of normal (ULN) SGOT no greater than 2.5 times ULN Renal: Creatinine no greater than ULN OR Creatinine clearance at least 60 mL/min Cardiovascular: No symptomatic congestive heart failure No unstable angina No cardiac arrhythmia Other: No other uncontrolled illness No active infection No allergy to platinum compounds, ...
Benign serous tumours are loculated, have one layer of flattened or cuboidal epithelium as well as the absence of mitoses. Papillae are occasionally present about the exterior or interior surfaces. Samples of serous cystadenomas can be found at ...
Risk of Malignancy in Unilocular Ovarian Cystic Tumors Less Than 10 Centimeters in Diameter Susan C. Modesitt, MD, Edward J. Pavlik, PhD, Frederick R. Ueland, MD, Paul D. DePriest, MD, R. J. Kryscio, PhD,
Results. Rustin GJ, van der Burg ME, Griffin CL, Guthrie D, Lamont A, Jayson GC, Kristensen G, Mediola C, Coens C, Qian W, Parmar MK, Swart AM, , , Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial., Lancet, 2010, 376, 9747, 1155-1163, doi: 10.1016/S0140-6736(10)61268-8.. ...
Darshak Shah, MD, MBBS, Ashish Padnani, MD, MBBS, Gaurav Sharma, MD, MBBS, Litong Du, MD, Saurabh Sharma, MD, MBBS. New York Hospital Queens, New York.. Background:. Appendiceal Mucocele is a very rare disease and found in only 0.3-0.4% appendectomies. It is characterized by mucoid accumulation in theappendix lumen and can present with diverse clinical features or just as an asymptomatic mass. It can be distinguished based on pathology as simple appendiceal mucocele, mucocele with epithelial hyperplasia, cystadenoma and cystadenocarcinoma. the last two are classified as neoplastic forms ...
TY - JOUR. T1 - Cystadenomas of the pancreas. T2 - Is enucleation an adequate operation?. AU - Talamini, Mark Adams. AU - Moesinger, Robert. AU - Yeo, Charles J.. AU - Poulose, Benjamin. AU - Hruban, Ralph H.. AU - Cameron, John L.. AU - Pitt, Henry A.. PY - 1998/6/1. Y1 - 1998/6/1. N2 - Objective: The objective was to determine whether surgical enucleation of mucinous cystadenoma of the pancreas is a safe and adequate operation. Summary Background Data: Mucinous cystadenomas of the pancreas are premalignant cystic lesions. Resection is the preferred treatment but often requires a pancreatoduodenectomy or a distal pancreatectomy with or without a splenectomy. Although these procedures can now be performed with a low mortality rate, substantial morbidity still occurs, especially in patients who have an otherwise normal pancreas. Methods: Between January 1990 and June 1997, 36 mucinous cystadenomas of the pancreas were resected at The Johns Hopkins Hospital. Most of these patients underwent ...
An ideal diagnostic approach would allow for the resection of only those lesions with present or near-future risk of malignancy, while excluding from surgery those individuals with either benign lesions or a prohibitive operative risk, thus minimizing the potential occurrence of mortality and morbidity associated with the surgical treatment of these cystic lesions. Recent advancements in imaging by CT, MRI, and endoscopic ultrasonography (EUS), linked with refinements in the pathological understanding of cystic neoplasms of the pancreas have furthered this effort. History and clinical criteria, such as age, gender, presence of symptoms, location of the neoplasm within the pancreas, as well as, morphology by cross-sectional imaging and cyst fluid analysis by EUS with fine-needle aspiration (EUS-FNA), all may play a role in the diagnosis of pancreatic cystic neoplasms and assessment of the need for resection. A recent analysis using decision analysis with Markov modeling has indicated that for ...
The TP53 mutation frequency in ovarian serous carcinomas has been reported to range between 50% and 80%, but a stringent analysis of TP53 using purified epithelial samples has not yet been performed to accurately assess the mutation frequency and to correlate it with the histologic grade. The purpose of this study was to assess the TP53 mutational profile in a relatively large series of high-grade (53 primary and 18 recurrent) and 13 low-grade ovarian serous tumors using DNA isolated from affinity-purified tumor cells and to correlate it with in vitro drug resistance. All samples were affinity purified, and the tumor DNA was analyzed for TP53 mutations in exons 4-9. In vitro drug resistance assays to carboplatin, cisplatin, paclitaxel, and taxotere were performed on the same tumor samples and correlated with the TP53 mutation status. TP53 mutations were detected in 57 (80.3%) of 71 high-grade carcinomas and in one (7.8%) of 13 low-grade serous tumors (an invasive low-grade serous carcinoma). The ...
A 53-yr-old woman with a history of hepatic cystadenoma 25 yr before presented with a simple hepatic cyst, which evolved over 9 yr into a complex cystadenoma with septations and internal bleeding. She was treated with a left hepatectomy. Review of the literature shows that hepatic cystadenomas, although rare, frequently can recur years later and have potential for malignant transformation. Histologic similarities of one variant with ovarian stroma raises interesting possibilities regarding the origin of these lesions. The best treatment results are obtained with radical excision ...