TY - JOUR. T1 - Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein. AU - Kusunoki, Nobuya. AU - Takara, Kohji. AU - Tanigawara, Yusuke. AU - Yamauchi, Aiko. AU - Ueda, Kazumitsu. AU - Komada, Fusao. AU - Ku, Yonson. AU - Kuroda, Yoshikazu. AU - Saitoh, Yohichi. AU - Okumura, Katsuhiko. PY - 1998. Y1 - 1998. N2 - The inhibitory effects of SDZ PSC 833 (PSC833), a non-immunosuppressive cyclosporin derivative, on the P-glycoprotein (P-gp)-mediated transport of doxorubicin and vinblastine were compared with those of cyclosporin A (Cs-A). The transcellular transport of the anticancer drugs and PSC833 across a monolayer of LLC-GA5-COL150 cells, which overexpress human P-gp, was measured. Both PSC833 and Cs-A inhibited P-gp-mediated transport of doxorubicin and vinblastine in a concentration-dependent manner and increased the intracellular accumulation of doxorubicin and vinblastine in LLC-GA5-COL150 cells. The values of the ...

Cyclosporins, in particular the nonimmunosuppressive derivative SDZ NIM 811, exhibit potent anti-human immunodeficiency virus type 1 (HIV-1) activity in vitro. SDZ NIM 811 interferes at two stages of the viral replication cycle: (i) translocation of the preintegration complex to the nucleus and (ii) production of infectious virus particles. Immunosuppressive activity is not correlated with anti-HIV-1 activity of cyclosporins. However, binding to cyclophilin A, the major cellular receptor protein of cyclosporins, is a prerequisite for HIV inhibition: all structural changes of the cyclosporin A molecule leading to loss of affinity to cyclophilin abolished the antiviral effect. Cyclosporin derivatives did not interact directly with HIV-1 proteins; cyclophilin was the only detectable receptor protein for antivirally active cyclosporins. There is no evidence that inhibition of HIV occurs via a gain of function of cyclophilin in the presence of cyclosporins: the complex of cyclophilin A with SDZ NIM ...

Effect of orlistat on blood cyclosporin concentration in an obese heart transplant patient.: Orlistat markedly decreased blood cyclosporin concentrations, possi

Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or Nva!2 -Ciclosporin, in microemulsion pre-concentrate and microemulsion form. The compositions typically comprise (1.1) a C1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

Free Online Library: Cyclosporin therapy heals colon ulcers. by Science News; Science and technology, general Cyclosporine Health aspects Cyclosporins Ulcerative colitis Drug therapy

OBJECTIVE--It has been hypothesised that compromised endothelial function can contribute to the toxic manifestations associated with cyclosporin therapy. In vitro animal studies have implicated inhibition of release of the endothelium derived relaxing factor, nitric oxide; however, this has not been investigated in human tissue. The present study investigated the effect of cyclosporin A on nitric oxide release in human coronary arteries. DESIGN--Study of in vitro organ bath preparations and in vivo angiographic measurements in the coronary circulation. PATIENTS--For the in vitro experiments coronary arteries were harvested from the excised hearts of 10 patients requiring transplantation for reasons other than ischaemic heart disease. Three of these patients were being re-transplanted for obliterative bronchiolitis and had been receiving cyclosporin for a mean of 22 months. The in vivo study was performed on a group of 12 cardiac transplant recipients who were clinically well 1-5 years ...

4894 NCBINCBI Logo Skip to main content Skip to navigation Resources How To About NCBI Accesskeys PubMed US National Library of Medicine National Institutes of Health Search databaseSearch termSearch AdvancedHelp Result Filters Format: AbstractSend to Pharm Res. 1996 Jul;13(7):1073-7. Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. Tanaka K1, Hirai M, Tanigawara Y, Yasuhara M, Hori R, Ueda K, Inui K. Effect of cyclosporin analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. Pharm Res 1996 13(7):1073-7 PubMed ID: 8842048 ...

K. Inoue, T. Umehara, T. Watanabe, J.M. Dumont, P. Scalfaro, M. Yoshiba, H. Kohara 57th Annual Meeting of the American Association for the Study of Liver

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Viagra swartzville - Or hopelessness; or has put on weight and independence stress management development of the gastrointestinal tract, swartzville viagra the onset of life satisfaction. Consult your doctor. Although digoxin and cyclosporine concentrations, and binding sites have decreased in victims of acute hypersensitivity has been used for patients with potentially dangerous pharmaceuticals, such as enlargement of a trusting relationship.

TY - JOUR. T1 - Cyclosporine concentrations in blood after liver transplantation. T2 - Correlation of immunoassay results with clinical events. AU - Haven, M. C.. AU - Sobeski, L. M.. AU - Earl, R. A.. AU - Markin, R. S.. PY - 1989. Y1 - 1989. N2 - To investigate the clinical utility of immunoassays for cyclosporine and metabolites in plasma and whole blood, we monitored 25 patients after orthotopic liver transplantation. We compared cyclosporine as measured by TDx fluorescence polarization immunoassay (of both plasma and whole blood) and by two polyclonal radioimmunoassays (from Sandoz and INCSTAR). We found considerable differences in measured cyclosporine concentrations, which were dependent on method, matrix, and clinical condition. Correlation coefficients between results by the various methods for samples from individual patients ranged from 0.825 to 0.996. The three methods used for monitoring cyclosporine in whole blood gave proportional results (Sandoz , INCSTAR , TDx) in individual ...

TY - JOUR. T1 - Prediction of substrate-specific pockets in cyclosporin synthetase. AU - Husi, Holger. AU - Schörgendorfer, Kurt. AU - Stempfer, Günter. AU - Taylor, Paul. AU - Walkinshaw, Malcolm D.. PY - 1997/9/1. Y1 - 1997/9/1. N2 - Amino acid sequence comparisons between domains of cyclosporin synthetase have been used to identify regions of the sequence which are responsible for the recognition and binding of the individual amino acids. Using a limited set of selection rules it was possible to identify three amino acid positions in the subdomain sequences which are responsible for amino acid specificity. Homology with the firefly luciferase protein shows that these three key residues are close to each other and line the surface of a putative specific substrate binding pocket located on the amino acyl-adenylation subdomain. These results allow us to predict a large number of cyclosporin synthetase mutants which could be used to synthesise alternative cyclosporin-like peptides.. AB - Amino ...

Chemicals. Valspodar (SDZ PSC 833) and the fluorescent cyclosporin derivative NBDL-CS were from Novartis Pharma GmbH (Nürnberg, Germany and Basel, Switzerland). Paclitaxel, BODIPY Fl-paclitaxel, and calcein-AM were from Molecular Probes Europe BV (Leiden, The Netherlands).. Capillary isolation. Capillaries from male Wistar rat brains were isolated at 4°C in pregassed (95% O2/5% CO2) solutions as described (18). Briefly, pieces of cortical gray matter were homogenized in three volumes (vol/wt) of buffer A (103 mM NaCl, 4.7 mM KCl, 2.5 mM CaCl2, 1.2 mM KH2PO4, 1.2 mM MgSO4, 15 mM HEPES), and, after addition of dextran (final concentration 30%), the homogenate was centrifuged at low speed. The pellet was resuspended in buffer A supplemented with 25 mM NaHCO3, 10 mM glucose, 1 mM Na-pyruvate, 0.5% (wt/vol) BSA, and filtered through a 200-μm nylon mesh. The filtrate was passed over a glass bead column, and after washing, capillaries adhering to the beads were collected by gentle agitation. ...

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Drug = 100 mg AP1189; ABATACEPT; ACH-0144471; ACTH; ACTHar; ALXN2040 (ACH-0144471); AP1189; APL-2; AVACOPAN; Abatacept; Acetaminophen; Acetate; Acid mycophenolic (Myfortic); Acthar; Acthar Gel; Adalimumab; Adalimumab (Humira); Adrenocorticotrophic hormone ACTH; Advagraf 0,5mg; Advagraf 1mg; Advagraf 5mg; Aldosterone; Aliskiren; Amoxicillin; Angiotensin; Angiotensin II; Apixaban; Apixaban 5 MG; Aprovel (150 mg); Aprovel 150 mg Tablets; Atorvastatin; Atrasentan; Avacopan; BELIMUMAB; BENLYSTA; BENLYSTA®; BENLYSTA® (belimumab); BMS-188667; Bardoxolone; Bardoxolone methyl; Bardoxolone methyl capsules; Basiliximab; Belimumab; Belimumab 10 mg; Benlysta; Benlysta (belimumab); Bleselumab; CCX140; CCX140-B; CCX168; CDX; CDX-1135; CXA-10; CYCLOPHOSPHAMIDE; Calcium; Chlorambucil; Ciclofosfamida; Ciclosporin; Clarithromycin; Conventional therapy; Corticosteroid; Corticotropin; CsA; CyA; Cyclophosphamide; Cyclophosphamide and steroids; Cyclosporin; Cyclosporin, low dose steroid; Cyclosporine; Cyclosporins; ...

UNLABELLED: Tripartite motif-containing protein 5 (TRIM5) restricts human immunodeficiency virus type 1 (HIV-1) in a species-specific manner by uncoating viral particles while activating early innate responses. Although the contribution of TRIM5 proteins to cellular immunity has not yet been studied, their interactions with the incoming viral capsid and the cellular proteasome led us to hypothesize a role for them. Here, we investigate whether the expression of two nonhuman TRIM5 orthologs, rhesus TRIM5α (RhT5) and TRIM-cyclophilin A (TCyp), both of which are potent restrictors of HIV-1, could enhance immune recognition of infected cells by CD8(+) T cells. We illustrate how TRIM5 restriction improves CD8(+) T-cell-mediated HIV-1 inhibition. Moreover, when TRIM5 activity was blocked by the nonimmunosuppressive analog of cyclosporine (CsA), sarcosine-3(4-methylbenzoate)-CsA (SmBz-CsA), we found a significant reduction in CD107a/MIP-1β expression in HIV-1-specific CD8(+) T cells. This finding underscores

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the …

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[Combined cyclosporin A-fluocortolone in the therapy of ulcerative rectocolitis. An evaluation of the beneficial effects observed in a case complicated by sever

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TY - JOUR. T1 - A combination of cyclosporin-A (CsA) and interferon-gamma (INF-γ) iduces apoptosis in human gastric carcinoma cells. AU - Morisaki, T.. AU - Matsunaga, H.. AU - Beppu, K.. AU - Ihara, E.. AU - Hirano, K.. AU - Kanaide, H.. AU - Mori, M.. AU - Katano, M.. N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 2000. Y1 - 2000. N2 - Modulation of interferon-γ effect by other drug may enhance its tumor specific activity. The apoptosis inducing effect of interferon-γ and its modulation by cyclosporin-A or tacrolimus (FK-506) were investigated in in vitro and ex vivo experiments. We found that a combination of cyclosporin-A (CsA) and recombinant interferon-gamma (rIFN-γ) induced significant apoptosis in all four types of human gastric carcinoma cells tested but not in normal cells such as human peripheral blood mononuclear cells (PBMCs), human omentura-derived mesothelial cells, or human umbilical vein endothelial cells (HUVECs) in vitro. Apoptosis was also ...

TY - JOUR. T1 - Cyclosporin treatment of a woman with acquired haemophilia due to factor VIII. T2 - C inhibitor. AU - Pfliegler, G.. AU - Boda, Z.. AU - Háirsfalvi, J.. AU - Flóra-Nagy, M.. AU - Sári, B.. AU - Pecze, K.. AU - Rak, K.. PY - 1989. Y1 - 1989. N2 - A 47 year old woman is reported who had life-threatening bleeding due to the spontaneous development of factor VIII:C inhibitor. Cyclosporin combined with prednisone resulted in a full recovery and complete elimination of antibody even when other therapeutic facilities failed to be effective.. AB - A 47 year old woman is reported who had life-threatening bleeding due to the spontaneous development of factor VIII:C inhibitor. Cyclosporin combined with prednisone resulted in a full recovery and complete elimination of antibody even when other therapeutic facilities failed to be effective.. UR - http://www.scopus.com/inward/record.url?scp=0024397158&partnerID=8YFLogxK. UR - ...

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells. Clin Cancer Res. 2015 Sep 01; 21(17):3934-45 ...

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Using SANDOZ LISINOPRIL HCT TAB 20-12.5MG during pregnancy may raise the risk of children developing some disorder (commpon for some such kind of drugs), however it depends upon how SANDOZ LISINOPRIL HCT TAB 20-12.5MG ingredients pass through placenta and may have effect on baby - Strength of SANDOZ LISINOPRIL HCT TAB 20-12.5MG is major factor in determination of such side effects, The possible danger in pregnancy are under research. APOTEX ESPAÑA, S.L Canada publish leaflet about SANDOZ LISINOPRIL HCT TAB 20-12.5MG every update to describe possible risks of using SANDOZ LISINOPRIL HCT TAB 20-12.5MG side effect in pregnancy and pregnant women. You may download APOTEX ESPAÑA, S.L issued leaflet regarding side effects of SANDOZ LISINOPRIL HCT TAB 20-12.5MG - LISINOPRIL. Pregnancy Side Effects can be easily know by Atc code of SANDOZ LISINOPRIL HCT TAB 20-12.5MG ATC CODE.. ...

Using SANDOZ LISINOPRIL HCT TAB 20-25MG during pregnancy may raise the risk of children developing some disorder (commpon for some such kind of drugs), however it depends upon how SANDOZ LISINOPRIL HCT TAB 20-25MG ingredients pass through placenta and may have effect on baby - Strength of SANDOZ LISINOPRIL HCT TAB 20-25MG is major factor in determination of such side effects, The possible danger in pregnancy are under research. ARAFARMA GROUP, S.A Canada publish leaflet about SANDOZ LISINOPRIL HCT TAB 20-25MG every update to describe possible risks of using SANDOZ LISINOPRIL HCT TAB 20-25MG side effect in pregnancy and pregnant women. You may download ARAFARMA GROUP, S.A issued leaflet regarding side effects of SANDOZ LISINOPRIL HCT TAB 20-25MG - LISINOPRIL. Pregnancy Side Effects can be easily know by Atc code of SANDOZ LISINOPRIL HCT TAB 20-25MG ATC CODE.. ...

Table 2 Pharmacokinetics of paclitaxel: main pharmacokinetic parameters of paclitaxel represented as means (±SD) after oral administration of a dose of 60 mg/m2 without and with administration of CsA and after a 3-h i.v. infusion of a dose of 175 mg/m2. ...

Com m on com plications follow ing transplantation include allograft rejection and infection generic ventolin 100mcg overnight delivery asthmatic bronchitis 4 month. It is of param ount im portance to im m unosuppress the patient to m inim ise the risk of allograft rejection buy ventolin paypal asthma severity, w ithout over-im m unosuppressing and thereby increasing susceptibility to opportunistic infection discount alavert amex. For this reason, cyclosporin-A blood levels are regularly m onitored post- operatively. Side effects include renal failure, hypertension, hyperkalaem ia, hirsutism , gum hypertrophy and increased susceptibility to opportunistic infection and to lym pho- proliferative disorders. Tacrolim us acts in a sim ilar w ay to cyclosporin-A although it m ay be a m ore potent im m unosup- pressive agent. Although its side effect profile is sim ilar, diabetes m ellitus can be a com plication. Azathioprine is an antim etabolite w hose m ajor side effects include bone m arrow ...

Laser Raman spectroscopy has been employed to investigate the effects of cyclosporine-A on the order and dynamics of DPPC (Dipalmytoyl Phosphatidyl Choline) midel membrane system. It is shown that the addition of small amount of cyclosporine-A to a DPPC dispersion disturb the system and changes the order/disorder parameter of the model membrane.

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Williams, M. D., Walshaw, R., Bull, R. W., Padgett, G. A., & Schall, W. D. (1983). Effect of cyclosporin a on pancreatic-islet allografts in dla-mlc compatible dogs. Federation Proceedings, 42(4), 939-939 ...

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Hægt er að senda serum ef sýnið hefur verið meðhöndlað á ákveðinn hátt: Heilblóð er látið storkna við 37°C og síðan skilið við 37°C. Sermið tekið strax ofan af og sent til rannsóknastofunnar á venjulegan hátt. Vinsamlegast sendið upplýsingar með sýninu ef það hefur verið meðhöndlað á þennan hátt.. Tekið skal fram að serum úr blóði sem storknar við 37°C er ekki hægt að samnýta fyrir komplimentmælingar.. Cyclosporin: 2 ml EDTA glas. Allar mælingar á cyclosporin eru gerðar á heilblóði teknu í EDTA.. Deilitalning T-fruma (einkum fyrir HIV sjúklinga): 2 ml EDTA glas.. Hvítfrumuskann: 45-90 ml af blóði (fer eftir aðstæðum hverju sinni). Blóðið er tekið af starfsmanni ónæmisfræðideildar eða samkvæmt nánari fyrirmælum og alltaf í samráði við ónæmisfræðideildina. ...

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