article{c02feb63-0c75-498d-9b63-6043d6df0ab2, abstract = {Background: Phage Display technology is a well established technique for high throughput screening of affinity ligands. Here we describe a new compact chromato-panning procedure for selection of suitable binders from a phage peptide display library. Results: Both phages and E. coli cells pass non-hindered through the interconnected pores of macroporous gel, so called cryogel. After coupling a ligand to a monolithic cryogel column, the phage library was applied on the column and non-bound phages were washed out. The selection of strong phage-binders was achieved already after the first panning cycle due to the efficient separation of phage-binders from phage-non-binders in chromatographic mode rather than in batch mode as in traditional biopanning procedures. E. coli cells were applied on the column for infection with the specifically bound phages. Conclusion: Chromato-panning allows combining several steps of the panning procedure ...

The goal of this thesis is to develop a full dimensional micromechanics-inspired constitutive model for polycrystalline shape-memory alloys. The model is presented in two forms: (1) The one-dimensional framework where we picture the ability of the model in capturing main properties of shape memory alloys such as superelasticity and shape-memory effect; (2) The full dimensional model where micromechanics origins of the model, the concepts emerged from those analysis and their relation to macroscopic properties in both single and polycrystals are presented.. We use this framework to study the effects of the texture and anisotropy in the material behavior. Since phase transformation often competes with plasticity in shape-memory alloys, we incorporate that phenomenon into our model. We also demonstrate the ability of the model to predict the response of the material and track the phase transformation process for multi-axial, proportional and non-proportional loading and unloading experiments. We ...

Shape-memory materials are featured by their ability to recover their original shape from a significant and seemingly plastic deformation when a particular stimulus is applied, which is known as the shape-memory effect.17-20,39-41 Shape-memory materials have been utilized in many fields, from aerospace engineering (e.g., in deployable structures and morphing wings) to medical devices (e.g., in stents and filters). Figure 1.3c and d show an example of a reversible bidirectional shape-memory free-standing copolymer network with two types of crystallizable domains that is capable of a fully reversible bidirectional shape-memory effect.41 This copolymer network is made of a multiphase copolyester urethane and consists of one set of crystallizable domain that determines the shape-shifting geometry, while the other domain of the network provides the thermally controlled actuation capability. This reversible bidirectional shape-memory technology can be inspirational to the design of many smart devices ...

This valve for gases, liquids, or powdery materials has an extremely simple and low-cost structure. Opening and closing functions are generated by using shape-memory wires, which move a diaphragm shutter element. The shape memory can reshape the diaphragm to lift away from the closed position. Then, with the change of temperature or current, it can return back to the closed position. This open/shut movement can be simple for on/off fluid requirements. It can also be rapid to effect displacement of a fluid. Particular positioning of shape-memory elements guarantees deicing functionality as resistance along the alloy can generate heat to prevent freezing.

According to a preferred embodiment of the invention, the window 4 has its bottom edge coupled to a driven member 7, in the form of a horizontal bar, which is controlled by the transmission 6. The bar 7 is provided with a seat in which the window 4 is slidably mounted so as to be able to perform a slight vertical movement with respect to the bar 7. The bar 7 carries a pair of cams 8, which are mounted articulated on the bar 7 and which can be brought from a horizontal, inoperative, position to a vertical, operative, position (in which they raise the window 4 by a small amount) by means of a shape-memory wire 9. Shape-memory alloys are known and have been used for some time. They are characterized by the property of changing state when a threshold temperature is exceeded. In the specific case of a shape-memory wire, the latter can be prearranged for reducing in length when its temperature of transition is exceeded. In the case in point, heating of the shape-memory wire 9 is obtained by causing it ...

A deformation sensor, which has excellent workability and a high degree of freedom in shape design and which can detect deformation and load in a wide area of components and portions, has a main body of sensor, electrodes which are connected to the main body of sensor and can output electric resistances, and a restraining component which restrains elastic deformation of at least a part of the main body of sensor. The main body of sensor has an elastomer, and spherical conductive fillers which are blended into the elastomer at a high filling rate in an approximately single-particle state, and is elastically deformable. In the main body of sensor, as an elastic deformation increases, the electric resistance increases.

An initial stress within a solid can arise to support external loads or from processes such as thermal expansion in inert matter or growth and remodelling in living materials. For this reason, it is useful to develop a mechanical framework of initially stressed solids irrespective of how this stress formed. An ideal way to do this is to write the free energy density psi in terms of initial stress tau and the elastic deformation gradient F, so we write psi = psi(F, tau). In this paper, we present a new constitutive condition for initially stressed materials, which we call the initial stress symmetry (ISS). We focus on two consequences of this condition. First, we examine how ISS restricts the possible choices of free energy densities psi = psi (F, tau) and present two examples of psi that satisfy the ISS. Second, we show that the initial stress can be derived from the Cauchy stress and the elastic deformation gradient. To illustrate, we take an example from biomechanics and calculate the optimal ...

Dec. 23, 2012 ? Scientists at The University of Manchester have identified how cells know which way up they need to be. The discovery could help in the fight against cancer because in the early stages of the disease the cells become disorganised.. Professor Charles Streuli and Dr Nasreen Akhtar of the Wellcome Trust Centre for Cell-Matrix Research have conducted new research that leads to a better understanding of cell polarity. Properly organised tissues are vital to maintaining functional organs and a healthy body. Part of being organised includes cells being in the correct position within the tissue and the right way up, because the top and bottom of cells have different functions.. The extracellular matrix (ECM) is a layer of protein rich material that surrounds tissues and helps to design and shape all of our organs. Previous studies have demonstrated that the ECM sticks to the cells and guides them into the right position. What hadnt been identified is how the ECM communicates that ...

This highly regarded hardcover engineering manual is mainly concerned with three important aspects of elasticity theory: finite elastic deformations, complex va

In some cases when the generated stress is immense, there is a rapid energy transfer through the dense and ordered packing of molecular single crystals and they are self-actuated by elastic deformation and/or by a ballistic event. This self-actuation phenomenon of crystals is termed thermosalient effect (Hüpf-Effekt) and is extremely rare propensity of certain crystalline solids capable of bending, twisting, curling, rolling or locomotion [2]. These systems are a prototype materials for novel, environmentally clean and efficient thermal-to-mechanical energy transformation. The capability of rapid energy transfer through the dense and ordered packing of single crystals evolves as a new platform for efficient dynamic elements, including artificial tissues and microfluidic elements. The fast energy transfer secured by efficient coupling between the thermal energy and mechanical energy stand as their main assets towards the design of fast actuators. The thermosalient effect is often accompanied ...

Zhu, X.L., Zhang, Y., Chandra, D., Cheng, S.C., Kikkawa, J.M. and Yang, S. Two-dimensional photonic crystals with anisotropic unit cells imprinted from poly(dimethylsiloxane) membranes under elastic deformation. Appl. Phys. Lett. 93, doi:10.1063/1.3006061 (2008). * (Selected to November 10, 2008 issue of Virtual J. Nanoscale Sci. & Tech., Am. Inst. Phys. & Am. Phys. Soc ...

Peckar, W, Schnörr, C, Rohr, K, Stiehl, H -S and Spetzger, U (1998). Linear and Incremental Estimation of Elastic Deformations in Medical Registration Using Prescribed Displacements. Machine Graphics & Vision. 7 807-829 ...

CIC energiGUNE researchers have developed a hierarchically graphitized carbon foam that has an interconnected microporous structure.

While officials in the executive branch, members of Congress and senior congressional staffers spin in and out of the private and public sectors, so too does privilege, power, access and, of course, money.

A full selection of Crown Princess images, showing you all the cabins, restaurants, bars and amenities. Including external Crown Princess photos.

A novel minicolumn chromatographic method to monitor the production of inclusion bodies during fermentation and an enzyme-linked immunosorbent assay (ELISA) system allowing direct analysis of the particles with surface-displayed antigens are described. A 33-kDa protein containing 306 amino acids with three sulfur bridges produced as inclusion bodies was labeled with polyclonal antibodies against 15 amino acid (anti-A15) and 17 amino acid (anti-B17) residues at the N- and C-terminal ends of the protein, respectively. Labeled particles were bound to macroporous monolithic protein A-cryogel adsorbents inserted into the open-ended wells of a 96-well plate (referred to as protein A-cryogel minicolumn plate). The concept behind this application is that the binding degree of inclusion bodies from lysed fermentation broth to the cryogel minicolumns increases with an increase in their concentration during fermentation. The technique allowed us to monitor the increase in the production levels of the ...

Supplementary Materialsoncotarget-09-7487-s001. via continous infusion would be more convenient for the patient. Here we describe and characterize a TM for retargeting UniCAR T cells to CD19 positive tumor cells. Moreover, we show the TM can efficiently be produced from maker cells housed inside a sponge-like biomimetic cryogel and, therefore, providing as an TM manufacturing plant for a protracted retargeting of UniCAR T cells CD33 to Compact disc19 positive leukemic cells. synthesized TM(A) Schematic watch from the UniCAR program. For retargeting of UniCAR T cells to Compact disc19 positive tumor cells a TM against the Compact disc19 antigen (anti-CD19 TM) needed to be built. In its existence, UniCAR T cells order ABT-869 will end up being cross-linked to Compact disc19 positive tumor cells that will finally result in lysis from the last mentioned. In the lack of the TM, UniCAR T cells will end up being powered down automatically. (B) For both and synthesis the reading body encoding the ...

This Cell Organization Worksheet is suitable for 9th Grade. In this cell organization worksheet, 9th graders conduct an experiment to create a three-dimensional model of a cell. Then they determine what items used from the list provided on cell parts and their various functions.

Multi-component artificial disc replacements (ADRs) facilitate in situ assembly within a disc space. In contrast to single-component ADRs, which use endplates constructed of a single material, assembled ADRs according to the invention allow the use of more than one material, even for the endplates themselves in certain embodiments. As such, materials with good wear characteristics such as chrome cobalt can be combined with materials such as Nitinol exhibiting other desirable characteristics such as the elasticity or shape-memory properties. Devices according to the invention can be used for other joints of the body, such as prosthetic knees and hips.

Effects of silica-gentamicin nanohybrids on osteogenic differentiation of human osteoblast-like SaOS-2 cells Wei He,1 Dina A Mosselhy,2,3 Yudong Zheng,1 Qingling Feng,4 Xiaoning Li,4 Xing Yang,4 Lina Yue,1 Simo-Pekka Hannula2 1School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, Peopleâ s Republic of China; 2Department of Chemistry and Materials Science, School of Chemical Engineering, Aalto University, Espoo, Finland; 3Microbiological Unit, Fish Diseases Department, Animal Health Research Institute, Giza, Egypt; 4State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, Peopleâ s Republic of China Introduction: In recent years, there has been an increasing interest in silica (SiO2) nanoparticles (NPs) as drug delivery systems. This interest is mainly attributed to the ease of their surface functionalization for drug loading. In orthopedic applications, gentamicin-loaded SiO2

Cell polarity is the property of cells to be spacially oriented in a tissue or organ. Loss of cell polarity is a hallmark of cancer and is associated with more aggressive tumours. In this grant, we propose experiments to understand a new family of proteins that act on cell polarity and proliferation to prevent cancer. We will study how the protein hScrib regulates the behaviour of breast cancer cells and assess whether alterations in hScrib are important for cancer development ...

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

Although most materials slightly expand when heated, there is a new class of rubber-like material that not only self-stretches upon cooling; it reverts back to its original shape when heated, all without physical manipulation.

Flexible displays, electronics and even batteries are currently being tested and will be part of our daily lives in a matter of years. The technology also holds tremendous promise for medical research and could contribute to treatment of Alzheimer's disease and a host of other conditions. But first, you need to find appropriate materials.

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In this work we have demonstrated a new approach to generate micropatterns on the sidewalls of polystyrene (PS) microchannels. The PS used is a thermal sha

i would like to optimize over elastic deformation of a body (finding the best deformation in some sens), under the constraint that we never reach the elastic limit. In the optimization procedure, i am wondering if i should go over all points of the body and check if the constraint is verified, or if it is sufficient to check on the surface. This would reduce the computational complexity of the optimization ...

We provide existence theorems in nonlinear elasticity for minimum problems modeling the deformations of a crystal with a given dislocation. A key technical difficulty is that due to the presence of a the dislocation the elastic deformation gradient cannot be in ...

|p style=text-indent:20px;|We consider the model problem of an elastic beam vibrating between two stops. More precisely the beam is clamped at its left end while its right end may undergo contact and collision events with two stops. We model the interaction between the beam and the stops either with Signorini complementarity conditions when the stops are perfectly rigid or with a normal compliance contact law allowing some penetration within the stops and given by a linear relationship between the shear stress and the penetration at some positive power |inline-formula||tex-math id=M1|\begin{document}$ \beta $\end{document}|/tex-math||/inline-formula| when contact occurs.|/p||p style=text-indent:20px;|Motivated by computational issues we study the evolution of the energy functional defined as the sum of the kinetic energy and the potential energy of elastic deformation of the beam. When contact is modelled with a normal compliance law we prove an energy conservation property. Then we interpret the

Abstract: The open arc welding robots have been used widely nowadays; however, the elastic deformations of every inner link inevitably affect the welding quality. In this paper, it proposes an effective method of service reliability assessment for the rigidity-flexibility coupling open arc welding robot. Firstly, a parametric virtual model of the robot is built in ADAMS/View-AutoFlex module. Secondly, the stochastic errors generated in the working process are simulated by a program created from pseudo-random numbers which have been written by multiplicative congruence method. Lastly, Monte Carlo sampling calculation is implemented for the virtual model, and large sample data of the dynamic characteristics in welding process are obtained and used to calculate the service reliability of the welding robot. This method includes simplicity (no need to solve complex mathematic model) and high accuracy which make it highly promising for application in mechanism design ...

A heart pacemaker system has an electrode line with a proximal end which is introduced into a connector of the pacemaker housing, and a distal end having an electrode head attachable to the heart of a user. One or more of the distal or proximal ends of the electrode line, the connector, or a region of the electrode line are provided with a component consisting of shape-memory metal. These components have a first shape at temperatures different from body temperature, and assume a second shape when at body temperature. The shape-memory metal component, if disposed at the proximal end of the electrode line or at the connector, is arrnaged to provide a firm mechanical and electrical connection of the electrode line with the pacemaker housing upon the change of shape of the component. The shape-memory metal component, if disposed at the distal end, is arranged to assist in providing, either directly or indirectly, a reliable, mechanical and electrical connection of the electrode line to the heart upon the

Today the US Patent & Trademark Office published a pair of patent applications relating to wireless charging devices like an Apple Pencil and an Apple Watch and more importantly a new haptic feedback system for Apple Watch that under consideration that will introduce an actuation member formed from a shape-memory alloy (SMA). The new material will allow iPhone, iPad and Apple Watch teams to reduce some of the bulk of each device due to this next-gen haptic feedback device could be made much smaller.

Experiments of in vitro angiogenesis are important tools for studying both the mechanisms of formation of new blood vessels and the potential development of therapeutic strategies to modulate neovascularisation (e.g., screening of new pharmacological molecules). One of the most frequently used angiogenesis assays is the culture of endothelial cells on a reconstituted basement membrane named Matrigel, since the cells constitute a capillary-like network which can be quantified by image analysis. In this paper, a global, robust and fully automated methodology is proposed to segment and quantify in vitro endothelial cell networks from greyscale images using mathematical morphology operators. After extracting the established cell network by means of a top-hat transformation and separating the tubular structures and the cell aggregates by size and shape an interpolation algorithm yields a reconstituted closed network. Using these image data results different kinds of quantitative parameters are calculated:

Intermediate two-dimensional scanning with a three-dimensional scanner to speed registration | Proximity sensor device | Radar system and method | Device and method for judging likelihood of collision between vehicle and target, vehicle collision avoidance... | Radar device and method of processing signal |

Lipid bilayers form the boundaries of the cell and its organelles. Many physiological processes, such as cell movement and division, involve bending and folding of the bilayer at high curvatures. Currently, bending of the bilayer is treated as an elastic deformation, such that its stress-strain response is i

The analysis of rubber-like materials undergoing large elastic deformations is a key topic in field of active polymers, like ionic polymers, hydrogels and nematic elastomers, as well as in biomechanics, for soft tissues. For biomechanics, the hot issue relays in the development of mathematical-physical models that are able to describe the behaviour of physiological processes involving highly deformable tissues, like the skin or the muscles, or hard tissue as cartilage and bones. Such bio-mechanical models and their validation through experiments in vivo or in vitro can be helpful for better understanding physiological processes, for the planning of surgical interventions, or even for designing advanced prosthetic devices. In our case, we focused on the development of a model that describes the contraction of cardiac tissue based on the notion of active distortions. Then, our model has been implemented in a computational code in order to asses its performance through a series of numerical ...

At the California Institute of Technology (F. Cirak, M. Ortiz) and at Rutgers University (A. M. Cuitiño ) further sophisticated computer calculations on the elastic deformations of an ultra-thin foil were undertaken. The resulting pictures were quite realistic. The fact that the foil folds very irregularly (first occurring when the plate holding the foil experiences a temperature difference of only one degree) is caused by the way in which it was manufactured. The thin foil is stretched over an approximately four-millimeter hole in a platinum holder and attaches itself to the platinum through adhesion alone. Although the foil over the hole is self-supporting, it is not stretched in a uniform manner. This tension works, at first, to stabilize the smooth form of the foil, so that with small temperature increases no folds appear. The computer simulations showed that if the samples were perfectly symmetrical, they would begin to bend with the smallest temperature increases. If the temperature ...

A cart for weighing small animals with the cart having a torsional undercarriage mechanism that directs the weight of an animal in a weighing pen through a single tension support member wherein the elastic deformation of the single tension support member is measured with an electrical resistance strain gauge mounted on the tension support member and a conventional digital strain gauge read-out device.

In the project ClothTiles, we present a prototyping platform to fabricate actuators of clothing. ClothTiles leverage flexible 3D-printing and Shape-Memory Alloys (SMAs) alongside new parametric actuation designs. We explore the concept of fabric actuation using a base element and then systematically explore methods of aggregating, scaling, and orienting prospects for extended actuation in clothing.. ...

NEW YORK (Reuters Health) - Women on chemotherapy for breast cancer may have tiny memory and thinking impairments compared with cancer-free women more than 20...

TY - JOUR. T1 - Effect of acquisition parameters on the accuracy of velocity encoded cine magnetic resonance imaging blood flow measurements. AU - Greil, Gerald. AU - Geva, Tal. AU - Maier, Stephan E.. AU - Powell, Andrew J.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2002. Y1 - 2002. N2 - Purpose: To investigate the effect of acquisition parameters on the accuracy of 2D velocity encoded cine magnetic resonance imaging (VEC MRI) flow measurements. Materials and Methods: Using a pulsatile flow phantom, through-plane flow measurements were performed on a flexible vessel made of polyvinyl alcohol cryogel (PVA), a material that mimics the MR signal and biomechanical properties of aortic tissue. Results: Repeated VEC MRI flow measurements (N = 20) under baseline conditions yielded an error of 0.8 ± 1.5%. Slice thickness, angle between flow and velocity encoding directions, spatial resolution, velocity encoding range, and radio frequency (RF) flip angles were varied over ...

4. I asked the wrong question. How do the homologous chromosomes pair up (mate/join)? How do they recognize that chromosome with whom to pair? If there are different genes on different chromosomes, I assume that this pairing would have to have 2 chromosomes with the same set of genes. Is this the 1 and the 2 of the 2n (one from the mother side, one from the father side)? Thus each pair of homologous chromosomes have a total of 4 sister chromatids, 2 on each of the homologous chromosomes. How the chromosomes pair correctly is my biggest stumbling point ...

Introduction. Plastics Plastics are often frowned upon. This is because people often think of them as cheap and not aesthetically pleasing. However they come in many different forms and often look very nice. Obviously there are types that do give the product a bad name. Mainly the cheap toys that are produced in the far east. This is not right and plastics should be seen as a real alternative and be able offer a huge amount of uses for this product. Polymers Polymers such as rubber, plastics and adhesives are organic structures. They can be natural, like amber and shellac, modified natural materials, like cellulose and casein, or synthetic, like nylon and polypropylene. ...read more. Middle. When subjected to pressure, thermoplastics can deform in two ways. Elastic deformation occurs in which the initially curled long chains stretch out and this deformation is recovered when the pressure is removed. At higher temperatures or pressures, viscous or plastic deformation occurs in which the secondary ...

Abstract. Mass-spring systems are of special interest for soft tissue modeling in surgical simulation due to their ease of implementation and real-time behavior. However, the parameter identification (masses, spring constants, mesh topology) still remains a challenge. In previous work, we proposed an approach based on the training of mass-spring systems according to known reference models. Our initial focus was the determination of mesh topology in 2D. In this paper, we extend the method to 3D. Furthermore, we introduce a new approach to simultaneously identify mesh topology and spring sti ness values. Linear elastic FEM deformation computations are used as reference. Additionally, our results show that uniform distributions of spring sti ness constants fails to simulate linear elastic deformations. ...

A nut is a type of fastener with a threaded hole. Nuts are almost always used in conjunction with a mating bolt to fasten multiple parts together. The two partners are kept together by a combination of their threads friction (with slight elastic deformation), a slight stretching of the bolt, and compression of the parts to be held together.. In applications where vibration or rotation may work a nut loose, various locking mechanisms may be employed: lock washers, jam nuts, specialist adhesive thread-locking fluid such as Loctite, safety pins (split pins) or lockwire in conjunction with castellated nuts, nylon inserts (nyloc nut), or slightly oval-shaped threads.. Square nuts, as well as bolt heads, were the first shape made and used to be the most common largely because they were much easier to manufacture, especially by hand. While rare today due to the reasons stated below for the preference of hexagonal nuts, they are occasionally used in some situations when a maximum amount of torque and ...

which is not very helpful if not misleading. They explain what happens to two of the values of that gas while the third stays the same. The act of ruling; administration of law; government; empire; authority; control. a legal code or complete body or system of laws. He was attacked while going about his lawful business. the advocacy of revision, especially in relation to court decisions. ... Hookes law - … To solve this equation for the function kV(V), first separate the variables, V on the left and P on the right. In terms of elastic deformation of materials, the methods of calculating the stresses from the measured strains are based on Hookes Law, explained here. a system of government based on a legal code. Whether or not they produce a disease, or a prosecution, is a function of the body politic -Anon quote. Define law. Therefore, one can write. In Garretts historical novel, Death of the Fox, this simile is voiced by Sir Francis Bacon. See Note at, a signature of a proxy, one who is not ...

The DEPARTMENT OF CELLULAR AND MOLECULAR BIOLOGY focuses on understanding the cell, the basic unit of Life. This Department gathers laboratories whose research interests span fundamental processes at the core of cell organization and function: the arrangement, replication and stability of genomes, epigenetics in gene expression, intracellular traffic, cell division, differentiation and evolution, and cellular recycling through programmed death. These studies converge with bottom-up endeavours, such as exploring the interactions between cells and biomaterials or the reconstruction and engineering of macromolecular assemblies. The model systems used to study these processes range from unicellular microorganisms, both bacteria and fungi, to mammalian cells and animal models. Our approaches are interdisciplinary, a watermark of CIB Margarita Salas, and bridge methodologies ranging from advanced optical and electron microscopies to functional genomics, with strong inputs from molecular biology, ...

This course is designed for students who seek to take bioinformatics courses but lack prerequisites in the biological sciences. The course covers essential aspects of biochemistry, cell biology, and molecular biology. Topics include the chemical foundations of life; cell organization and function; the structure and function of macromolecules; gene expression- transcription,

In this Dialog we wish to open the way for another political orientation, one that relies neither on the idea of globalization nor on those of sovereignty, identity and individuality. Our assumption is that most of the ideas about the Body Politic come from ideas about the biological body, and vice versa. There has always been a two-way stream of exchanges between biology, law, religion and social theory to the point that it is very difficult when people talk about ecosystems, identity, genetics, organism or globalization to decide if they speak about human or non-human entities. Biologists dont seem to worry that they import social theory to talk about organs and tissues, sociologists dont hesitate to use a legal conception coming from Church history to define the individual, while economists happily mobilize what they take as a naturalistic notion of competition to render the optimum calculable, while organization theorists borrow offhandedly the DNA metaphor of cell organization, and so ...

The invention concerns a device comprising a support (11) in the thickness of which is produced a supply chamber (12) with an inlet duct (13) for nutrient liquid and a discharge duct (14) for said liquid. A capsule (22) capable of receiving organic cells is provided on the support (11). The supply chamber (12) and the support (11) are separated by a porous membrane (16) comprising an array of electrodes (17) arranged so as to be in contact with different zones of the group of cells, thereby enabling their electrophysiological activity to be analyzed. The device enables to increase the life span of cells and to carry out analyses simply and without affecting the cell organization.