TY - JOUR. T1 - Randomised placebo-controlled cross-over study examining the role of anamorelin in mesothelioma (The ANTHEM study). T2 - Rationale and protocol. AU - Hoon, Siao Nge. AU - Fyfe, Katrina. AU - Peddle-Mcintyre, Carolyn J.. AU - Bowyer, Samantha. AU - Hawkins, Felicity. AU - Jeffery, Emily. AU - Chih, Hui Jun. AU - Creaney, Jenette. AU - Nowak, Anna. AU - Brims, Fraser. PY - 2020/3/25. Y1 - 2020/3/25. N2 - Introduction Cachexia is common in malignant mesothelioma (MM); half of patients have malnutrition and low skeletal muscle mass. Malnourished patients have worse quality of life (QoL). Weight loss is strongly associated with poor survival. Anamorelin is an oral ghrelin receptor agonist that improves appetite, body weight and QoL in advanced cancer. The aim of this study is to examine the efficacy of anamorelin in improving appendicular skeletal muscle mass (ASM) and patient-reported outcomes in patients with MM with cachexia. Methods and analysis A single-centre, phase II, ...
This will be a single-dose, randomized, double-blind, active- and placebo-controlled, double dummy, 6-way crossover study to determine the abuse potential of
There is substantial evidence that the prevalence of sleep disorders is an important occupational health problem, especially among health care professionals on night or on rotating work shifts [1-10]. An important aspect of the work environment of nurses is that they are required to work at any point in the 24 hour day [11]. Night work is associated with disturbed sleep and impaired alertness. The impact of sleep is the result of the circadian interference with sleep during daylight hours and circadian suppression of pineal gland by light at night [12].. The definition of insomnia is a complaint of disturbed sleep, manifested as difficulties in sleep initiation, sleep maintenance, early morning awakenings, or nonrestorative sleep. Many sources also add the presence of associated daytime impairments, such as fatigue, irritability, decreased memory and concentration, and pervasive malaise affecting many aspects of daytime functioning [13]. In a recent study, 32% of night-shift workers reported ...
... MOUNTAIN VIEW Calif. Sept. 24 2013 /PRNew...The trial is a double-blind placebo-controlled crossover study in whi...Those children absent a genetic diagnosis will be recruited through th...The primary endpoints in this study are improvement in disease severit...,Edison,Pharmaceuticals,Announces,Initiation,of,NIH-Sponsored,EPI-743,Clinical,Trial,with,NIH,Undiagnosed,Diseases,Program,Patients,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
An open-label, randomized, two-treatment, two period crossover, single-dose study to determine the relative bioavailability of fixed combination of final market image (FMI) aliskiren/valsartan 150/80 mg tablets and the free combination of aliskiren 150 mg and valsartan 80 mg in healthy subjects ...
The purpose of this study is to evaluate the effect of two doses of bilastine (20 and 100 mg) compared to bilastine 20 mg administered with ketoconazole 400 mg, moxifloxacin 400 mg, and placebo. Subjects will receive each of the five study treatments in a crossover fashion administered once daily for 4 days ...
We used a randomized, double-blind, placebo-controlled cross-over study design in two phases with a drug-free interval between the phases of 4 weeks. Subjects were given ritonavir or placebo orally for 3 days. On the first day, ritonavir 200 mg or placebo was given at 8 A.M., 4 P.M., and 11 P.M. to 12 A.M. On the second day, the dose of ritonavir was increased to 300 mg three times with the same timing, and the last dose of 300 mg of ritonavir or placebo was given on the morning of the third day. On the second day, at approximately 6 P.M., 2 h after the afternoon dose of ritonavir or placebo, fentanyl 5 μg/kg was injected intravenously in 2 min. To prevent the sedative and respiratory depressant effects of fentanyl, 0.1 mg of naloxone was given intravenously 5 min before the fentanyl injection and an additional dose of 0.1 mg with the fentanyl. Additional doses of naloxone were used if needed to counteract the side effects of fentanyl. Peripheral arteriolar oxygen saturation and respiratory ...
This is a randomized, placebo-controlled study designed to evaluate skin irritation, skin tolerability, and adhesion of the 350 mg DTP-system following 3 consecutive 7-day applications to 3 specific areas of the body (upper back, upper arm, side of torso) of elderly Alzheimers patients. The total exposure time for the DTP-system is 21 days.. All patients receive 1 Donepezil Transdermal Patch (DTP-system) and 1 placebo patch, each applied to opposite sides of the body (e.g., placebo patch to the left side of the upper back, and DTP-system to the right side of the upper back). Patients are randomized to receive the active patch to either the left or the right side of the body according to 1 of 6 treatment sequences listed below. The treatment sequence is repeated for the opposite side of the body for a total of 12 treatment sequences (4 patients in each treatment sequence). The patches are applied to one of 3 body locations for 7 days, for a total exposure period of 21 days, according to one of ...
Throughout human evolution, infectious diseases have been a primary cause of death. Detection of subtle cues indicating sickness and avoidance of sick conspecifics would therefore be an adaptive way of coping with an environment fraught with pathogens. This study determines how humans perceive and integrate early cues of sickness in conspecifics sampled just hours after the induction of immune system activation, and the underlying neural mechanisms for this detection. In a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharide (LPS)]. Facial photographs and body odor samples were taken from the same donors when sick (LPS-injected) and when healthy (saline-injected) and subsequently were presented to a separate group of participants (n = 30) who rated their liking of the presented person during fMRI scanning. Faces were less socially desirable when sick, and sick body odors tended to lower ...
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TY - JOUR. T1 - Arterial visualization by contrast-enhanced moving-table MR angiography. T2 - Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers. AU - Hayashi, Hiromitsu. AU - Yuasa, Yuji. AU - Amano, Yasuo. AU - Tanimoto, Akihiro. AU - Saito, Yoko. AU - Yoshioka, Kunihiro. AU - Kita, Miho. AU - Kumazaki, Tatsuo. AU - Hiramatsu, Kyoichi. PY - 2008/9/1. Y1 - 2008/9/1. N2 - Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 ...
Background and aim: Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena® ELFA®955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements. Method: A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement. Result: Chronic WGOE supplementation did not affect any measures of cognition. Conclusion: It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic
Background: The prevention and treatment of obesity is a public health challenge. Objective: We investigated the effects of dietary composition, insulin sensitivity (SI), and energy balance on predicted changes in body composition. Design: In a randomized crossover design study, 39 normal-weight (n = 23), overweight (n = 8), and obese (n = 8) men and women (aged 25-36 y) each followed a 15-d isocaloric high-fat (HF; 50% fat) and high-carbohydrate [HC; 55% carbohydrate (CHO)] diet with a 4-6-wk washout period during the first year. During each treatment, energy balance was measured while the subjects were inactive by using indirect calorimetry on day 15, and S I was measured by using a euglycemic clamp study (40 mU · m-2· min-1) on day 16. Weight and body composition were then measured annually for 4 y. The outcomes for fat mass, percentage body fat, and weight were measured by using a linear 2-stage mixed model. Results: CHO balance (day 15) and SI (day 16) on the HC diet were highly and ...
This study used a multicenter, randomized, prospective, controlled, open-label, two-period crossover design. Individuals who were routinely treated with intensive, multi-injection insulin therapy using regular human or rapid-acting insulin and insulin glargine were recruited.. The participants entered a 2-week screening period, and if the acceptance criteria were satisfied and written informed consent was given, they were randomly assigned by means of a computer-generated blind random process to one of four cohorts. The first 3-week treatment phase consisted of insulin administration either by SI, a single I-Port device, or two separate I-Port devices (Dual I-Port). Using a two-period crossover design, the participants were reassigned to an alternate treatment regimen for an additional 3 weeks as indicated in Figure 2.. All regimens administered regular human or rapid-acting insulin and insulin glargine, a minimum of two injections daily of either Novolin, Humulin, NovoLog, Humalog, or Apidra ...
Adenosine might provoke bronchospasm in certain susceptible patients such as those with asthma or those on maintenance doses of bronchodilators or steroids. The selectivity of regadenoson was therefore of great interest to study for its safety and efficacy in such patients. The final answer is not yet in, and more studies are needed, but there are some preliminary data.. Prior studies have suggested that with prophylactic pre-treatment with a B-2 agonist, adenosine could be given to patients with mild asthma or chronic obstructive lung disease (COPD). It should be noted the majority of patients with COPD but no bronchospasm could be tested with adenosine without any serious problem (39). Further, tachypnea is common after adenosine infusion and is not due to changes in airway resistance or pulmonary capillary wedge pressure but rather to stimulation of carotid body receptors (40,41).. A randomized double-blind, placebo-controlled cross-over trial assessed the safety of regadenoson in 48 patients ...
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The study design is two-period crossover study (repeated measures design) . Participants will complete two trials of 3-minutes pre-oxygenation via non-rebreather mask (NRM)., One trial will have an oxygen flow rate of 15lpm, The other will have the flow-meter valve turned wide open. The end-tidal oxygen (ETO2) will be measured at the end of each trial. The first trial will be followed by a washout period of 2 minutes. Allocation to the first trial (15lpm or fully open valve) will be randomised. ...
Jaguar has announced it will showcase a new design study based on the F-Type convertible at this weekends Goodwood Festival of Speed. The F-Type show car will be joined at the annual event by Jaguars latest crop of performance vehicles. Jaguar...
Passive Tomography for Spent Fuel Verification: Analysis Framework and Instrument Design Study. Proceedings of 37th ESARDA Symposium on Safeguards and Nuclear Non-Proliferation, Manchester, UK, 19-21 May 2015. pp 949- ...
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40+/-11 vs. 45+/-9%, P=0.02), a smaller ...
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40+/-11 vs. 45+/-9%, P=0.02), a smaller ...
Background: Abediterol is a novel, once-daily LABA under development for the treatment of asthma and COPD. The peak bronchodilator effect of single doses of abediterol delivered via Genuair® vs placebo was assessed against salbutamol 400 µg in patients with persistent stable asthma.. Methods: Adult patients were randomized to receive abediterol (0.313, 0.625, 1.25 or 2.5 μg), salbutamol 400 μg and placebo in a 6-period crossover study. Endpoints included change from baseline to peak (primary endpoint) and trough FEV1 and FVC. Safety was also assessed.. Results: A total of 58/62 randomized patients completed the study. Abediterol (all doses) and salbutamol achieved clinically and statistically significant improvements from baseline in peak FEV1 vs placebo (p,0.0001; Table). Peak FEV1 magnitude of effect with abediterol (all doses except 0.313 μg) was similar to salbutamol. Abediterol had a dose-dependent and significantly greater effect on trough FEV1 vs placebo (p,0.0001) and vs salbutamol ...
Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress responses. Challenge models may thus be a sensitive measure to study the bodys health. The objective of this study was to select a dietary challenge model for the assessment of inflammatory resilience. Meals are a challenge to metabolic homeostasis and are suggested to affect inflammatory pathways, yet data in literature are limited and inconsistent. The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6,
PURPOSE: To examine the effects of static and dynamic stretching routines performed as part of a comprehensive warm-up on flexibility and sprint running, jumping and change of direction tests in team sport athletes. METHODS: A randomized, controlled, cross-over study design with experimenter blinding was conducted. On separate days, 20 male team sport athletes completed a comprehensive warm-up routine. After a low-intensity warm-up a 5-s static stretch (5S), 30-s static stretch (30S; 3×10-s stretches), 5-repetition (per muscle group) dynamic stretch (DYN) or no stretch (NS) protocol was completed; stretches were done on 7 lower body and 2 upper body regions ...
METHODS: In a double-blind placebo-controlled cross-over design postmenopausal women (60 +/- 5 years, n = 14) were randomized to either start with placebo or E2 (Estrofem, Novo Nordisk, Copenhagen, Denmark) 2 mg/d given orally over 3 months and to switch thereafter for another 3 months of therapy. At baseline, a stress echocardiography was performed to exclude CAD. CFR was determined by coronary sinus CMR flow measurements (with motion-adapted gating and interactive acquisition window control; spatial/temporal resolution of 0.8 x 0.9 mm2/25-30 ms) which were performed at rest and during vasodilation (dipyridamole 0.56 mg/kg over 4 minutes IV) at baseline, and after 3 and 6 months of therapy, respectively ...
Theres some interesting stuff. Never mind the shifts in cholesterol levels (it was a cross over study with a low-fat high-carb period), these are exactly what you would expect. The study was careful not to check the LDL particle sizes and numbers otherwise they might have found the small dense LDL which would probably have predominated on the HC period. That is along side the lower HDL figure they did report on the HC phase. They were also careful not to look at glycosylation levels (HbA1c would be useless in a short study like this, but fructosamine looks at two weeks of glycosylation and would have been interesting) to see what was happening in the "eating" world, rather than during a glucose tolerance test. You dont put this sort of control in to nutrition studies because it might not get you the answers you want. High fat diets DO tend to produce higher fasting glucose levels and can even produce higher fasting insulin levels, as here, but 24h AUC for insulin and glucose would be lower. ...
Actor Laurence Fishburne of CBSs hit show CSI spoke to Harry Smith about his character Dr. Ray Langstons cross-over into the two other CSI shows, Miami and New York.
Nowadays, life has become so busy that people do not get enough time to take care of themselves. Some of them want to keep themselves fit and in shape but that becomes quite difficult because of their busy lifestyle. Going out to the GYM requires a lot of time and after being busy all day long people feel so tired that they do not have enough energy for performing exercises. Such people want to get more results in lesser time and effort which can only be possible by using Cable cross over the machine. If a person is using a high-quality cable crossover machine then he would get his desired results. The quality of the product plays an important role in body transformation. The following are some of the benefits of cable cross overs that will change the lives of people.. Prevention from diseases:. People are suffering from different diseases because of their busy lifestyle. They remain stuck in one place and slowly all the physical activities are reducing from our daily life whether it is off work ...
FIRST DIVISION - THE SIMULAR CHROMOSOMES LINE UP IN THE CENTER OF THE CELL IN PAIRS. THE PAIRS ARE THEN PULLED APART SO EACH NEW CELL HAS ONE COPY OF EACH CHROMOSOMES. SOME OF THE FATHERS CHROMOSOMES AND SOME OF THE MOTHERS CHROMOSOMES GO INTO EACH CELL. SECOND DIVISION - THE CHROMOSOMES LINE UP IN THE CENTER OF THE EACH CELL. THE SPINDLE FIBRES PULL THE CHROMATIDS APART AND SOME CROSS OVER OCOURS. THE CYTOPLASM DIVIDES AND 4 GAMETES FORM EACH GAMETE IS GENETICALLY DIFFERENT DUE TO CROSS OVER. MITOSIS CONTINUES TO DUPLICATE THE CELLS.. ...
The University of Gloucestershire has a vibrant academic community where creative research and cutting-edge scholarship are conducted at a high level. Our learning-led environment enables research to thrive, providing the best support for students.
Overview over study procedure. The study was conducted among all MG patients in Norway and the contiguous regions of South- and North Holland in the Netherlands
Study design: An open-label, randomized cross-over study. Group 1 represents patients starting with rosuvastatin plus omega-3 PUFAs, Group 2 represents patients
In a crossover trial, participants receive more than 1 of the treatments under investigation, usually in a randomly determined sequence, and with a prespecified amount of time (a ) between sequential treatments. The participants and the investigators are generally to the treatment assignment (double-blinded). This experimental design is often used for evaluating drug treatments. Each participant serves as his or her own control, thereby eliminating variability when comparing treatment effects and reducing the sample size needed to detect a effect. Most considerations of parallel-design randomized trials apply. Rather than indicating which participants were assigned to which condition, the CONSORT flow
In a crossover trial, participants receive more than 1 of the treatments under investigation, usually in a randomly determined sequence, and with a prespecified amount of time (a ) between sequential treatments. The participants and the investigators are generally to the treatment assignment (double-blinded). This experimental design is often used for evaluating drug treatments. Each participant serves as his or her own control, thereby eliminating variability when comparing treatment effects and reducing the sample size needed to detect a effect. Most considerations of parallel-design randomized trials apply. Rather than indicating which participants were assigned to which condition, the CONSORT flow
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WOH! Do not fear Crossing over into your promised Land? What is there to fear for me? I was afraid because I still do not know what my promised land looks like, what it is that God has for me, I was afraid of the unknown. I was afraid that I would not hear God and that I would be being still, waiting for a long time. I was afraid that I would not hear God and that I would step out without hearing Him, because I wanted to DO. I was afraid of what people might think, both if I waited much longer and when I cross over into the promised land. I was afraid, and this is one that just echoes Beth Moore from the week 5 video... I was afraid that I WOULD FAIL GOD, that I would not be ENOUGH ...
NO LOADS OVER 12 WIDE ALLOWED. For loads over 12 there is a county road, Sandridge Rd., that parallels 103 that can be used. It has numerous cross over streets to 103 and intersects US 101 at MP 13.9. For County approval call Pacific Co (360) 875-9368. *WSDOT Does Not Guarantee Height Clearances ...
I dont think we, in this reality, can possibly know. Not with, like you said, our limited perception. The computer in front of you is basically empty space, yet you and I perceive such things as solid. We know darn well that its only a very tiny bit of solid and even that isnt solid. I think we know reality once we cross over to our spiritual base of existence. We simply cant see the smallest of small with our scientific equipment, yet ...
Slash Cut Turn Outs need to be added to the ends, and I have asked if possible the cross over on the right pipe be changed slightly. Between the front down tubes modified from straight to more of an S bend, which will also increase the small tight bend around the engine to a sweeping curve also. Waiting to see if these mods are possible ...
There are many tools that cells could use to separate DNA strands that cross over during meiosis. UC Davis researchers have identified the right tools for the job.
How can I communicate with loved ones who have crossed over, you ask? The loss of a loved one is always difficult. Its only natural to want to contact them and continue communication. We believe loved ones who cross over do check...
The most detailed carbon parameter results are for DIC, as this parameter was measured on all of the cruises (Table 3). The next most frequently measured parameter was fCO2, followed by TAlk and pH (Table 4, Table 5, and Table 6), respectively. DIC CRMs were available to the investigators for almost every cruise during the survey. In general, there is excellent agreement between DIC data sets at the crossover locations. At the beginning of the program, the goal was to obtain agreements between cruises that were less than 4.0 µmol/kg. On 31 of 41 crossover comparisons the uncorrected DIC differences were less than this value, and on 24 of the comparisons the differences were less than 2.0 µmol/kg.. Most of the cruises that did not meet this criteria occurred at the beginning of the program when methods were still being developed, and one comparison was during a strong El Niño event where the upper water column hydrography was significantly different from normal (Feely et al. 1995). When the ...
OPTICAL DESIGN STUDIES WILL BE CARRIED OUT TO DEVISE AN OPTICS MODULE FOR FLOW CYTOMETRY SUCH THAT THE FLOW CHAMBER BECOMES AN INTEGRAL PART OF THE OPTICAL SYSTEM AND FLUOR- ESCENCE IS COLLECTED FOR ALMOST A FULL 4 STERIDIANS (DUAL- HEMISPHERICAL SPACE). AN IMPROVEMENT OF AT LEAST A FACTOR OF FOUR IN THE EFFICIENCY OF LIGHT COLLECTION OVER EXISTING DESIGNS AND BY MORE THAN AN ORDER OF MAGNITUDE OV .... ...
Hello and thanks for posting. Sounds like you could very well have those pesky efavirenz side effects; those the swelling in the chest doesnt. A switch to an alternate treatment could help-...
You can also start on SWAMI, but consider the "black dots" to be neutral for now. This will greatly broaden your food options. Then you can do the official wash-out period in January and February. No, this is not the way Dr D intends the SWAMI to be used, but it is a valid way of using it. Remember that the "black dot" foods are not quite as bad for you as the outright avoids. Some of them may act as neutrals in your body, while others you may not be able to tolerate at all, and most of them are probably fine if you eat them a couple times a year but avoid the rest of the time. Still, including the black dots for now, as a way to ease into SWAMI, just means that healing might be a bit slower than if you avoided them carefully ...
This is a single blinded, randomized, cross-over design. Up to 12 patients will be randomly administered a single 10.0 mCi dose of 123I-MIP-1072 or 123
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CARGO study (Copeptin after arginine infusion in the diagnosis of polyuria polydipsia syndrome): observational study evaluating the value of arginine infusion and copeptin measurements in the differential diagnosis of polyuria polydipsia syndrome CARGOx study (Copeptin after arginine infusion compared to copeptin after hypertonic saline infusion for the differential diagnosis of diabetes insipidus) GOLD study (Effects of GLP-1 analogues on fluid intake in patients with primary polydipsia): randomized placebo-controlled cross-over study evaluating the effect of GLP-1 analogs on fluid intake in patients with primary polydipsia GATE study (Effects of GLP-1 and analogues on fluid intake in healthy volunteers): randomized placebo-controlled cross-over study evaluating the effect of GLP-1 analogs on fluid intake in healthy volunteers SAND study (SGLT-2 inhibitors for treatment of SIADH, a placebo-controlled randomised study) HIT study (Hyponatremia Intervention study) COMEN study (Copeptin in ...
OSU6162 caused a remarkable improvement in mental stamina, as evaluated by a self-assessment scale on mental fatigue. Statistical significance was reached on the primary endpoint (Mental Fatigue Scale). There was a trend towards improvement in the secondary endpoints processing speed and attention. Principal component analysis showed an overall positive treatment effect in 7 of 12 patients. Beneficial responses were seen already during the first few days of active drug treatment. Increasing dosage caused no further improvement. Adverse reactions consisted of short-lasting mild nausea and attenuated appetite. These side effects disappeared upon dose reduction. ...
TY - JOUR. T1 - A double-blind evaluation of skin test suppression produced by two doses of terfenadine. AU - Bantz, Eric W.. AU - Dolen, William K.. AU - Nelson, Harold S.. PY - 1987/1/1. Y1 - 1987/1/1. N2 - For some patients, terfenadine, in the currently recommended dose of 60 mg twice daily (bid), may be only modestly effective in the treatment of allergic rhinitis. In a double-blind placebo-controlled crossover study of 12 patients, a larger dose (300 mg bid) was evaluated for its suppression of titrated skin tests to histamine and compound 48/80 to determine whether this regimen might result in greater suppression while it maintained the freedom from side effects of the presently recommended dose. In seven patients, skin test suppression by these two doses of terfenadine, each administered for 3 days, was compared to that produced in an earlier study by 3 days of treatment with chlorpheniramine (8 mg three times a day). The 300 mg bid terfenadine regimen produced significantly greater skin ...