TY - JOUR. T1 - Randomised placebo-controlled cross-over study examining the role of anamorelin in mesothelioma (The ANTHEM study). T2 - Rationale and protocol. AU - Hoon, Siao Nge. AU - Fyfe, Katrina. AU - Peddle-Mcintyre, Carolyn J.. AU - Bowyer, Samantha. AU - Hawkins, Felicity. AU - Jeffery, Emily. AU - Chih, Hui Jun. AU - Creaney, Jenette. AU - Nowak, Anna. AU - Brims, Fraser. PY - 2020/3/25. Y1 - 2020/3/25. N2 - Introduction Cachexia is common in malignant mesothelioma (MM); half of patients have malnutrition and low skeletal muscle mass. Malnourished patients have worse quality of life (QoL). Weight loss is strongly associated with poor survival. Anamorelin is an oral ghrelin receptor agonist that improves appetite, body weight and QoL in advanced cancer. The aim of this study is to examine the efficacy of anamorelin in improving appendicular skeletal muscle mass (ASM) and patient-reported outcomes in patients with MM with cachexia. Methods and analysis A single-centre, phase II, ...
This will be a single-dose, randomized, double-blind, active- and placebo-controlled, double dummy, 6-way crossover study to determine the abuse potential of
Seventy-five patients meeting international diagnostic criteria for narcolepsy enrolled in a 6-week, three-period, randomized, crossover, placebo-controlled trial. Patients received placebo, modafinil 200 mg, or modafinil 400 mg in divided doses (morning and noon). Evaluations occurred at baseline a …
There is substantial evidence that the prevalence of sleep disorders is an important occupational health problem, especially among health care professionals on night or on rotating work shifts [1-10]. An important aspect of the work environment of nurses is that they are required to work at any point in the 24 hour day [11]. Night work is associated with disturbed sleep and impaired alertness. The impact of sleep is the result of the circadian interference with sleep during daylight hours and circadian suppression of pineal gland by light at night [12].. The definition of insomnia is a complaint of disturbed sleep, manifested as difficulties in sleep initiation, sleep maintenance, early morning awakenings, or nonrestorative sleep. Many sources also add the presence of associated daytime impairments, such as fatigue, irritability, decreased memory and concentration, and pervasive malaise affecting many aspects of daytime functioning [13]. In a recent study, 32% of night-shift workers reported ...
... MOUNTAIN VIEW Calif. Sept. 24 2013 /PRNew...The trial is a double-blind placebo-controlled crossover study in whi...Those children absent a genetic diagnosis will be recruited through th...The primary endpoints in this study are improvement in disease severit...,Edison,Pharmaceuticals,Announces,Initiation,of,NIH-Sponsored,EPI-743,Clinical,Trial,with,NIH,Undiagnosed,Diseases,Program,Patients,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
An open-label, randomized, two-treatment, two period crossover, single-dose study to determine the relative bioavailability of fixed combination of final market image (FMI) aliskiren/valsartan 150/80 mg tablets and the free combination of aliskiren 150 mg and valsartan 80 mg in healthy subjects ...
The purpose of this study is to evaluate the effect of two doses of bilastine (20 and 100 mg) compared to bilastine 20 mg administered with ketoconazole 400 mg, moxifloxacin 400 mg, and placebo. Subjects will receive each of the five study treatments in a crossover fashion administered once daily for 4 days ...
We used a randomized, double-blind, placebo-controlled cross-over study design in two phases with a drug-free interval between the phases of 4 weeks. Subjects were given ritonavir or placebo orally for 3 days. On the first day, ritonavir 200 mg or placebo was given at 8 A.M., 4 P.M., and 11 P.M. to 12 A.M. On the second day, the dose of ritonavir was increased to 300 mg three times with the same timing, and the last dose of 300 mg of ritonavir or placebo was given on the morning of the third day. On the second day, at approximately 6 P.M., 2 h after the afternoon dose of ritonavir or placebo, fentanyl 5 μg/kg was injected intravenously in 2 min. To prevent the sedative and respiratory depressant effects of fentanyl, 0.1 mg of naloxone was given intravenously 5 min before the fentanyl injection and an additional dose of 0.1 mg with the fentanyl. Additional doses of naloxone were used if needed to counteract the side effects of fentanyl. Peripheral arteriolar oxygen saturation and respiratory ...
This is a randomized, placebo-controlled study designed to evaluate skin irritation, skin tolerability, and adhesion of the 350 mg DTP-system following 3 consecutive 7-day applications to 3 specific areas of the body (upper back, upper arm, side of torso) of elderly Alzheimers patients. The total exposure time for the DTP-system is 21 days.. All patients receive 1 Donepezil Transdermal Patch (DTP-system) and 1 placebo patch, each applied to opposite sides of the body (e.g., placebo patch to the left side of the upper back, and DTP-system to the right side of the upper back). Patients are randomized to receive the active patch to either the left or the right side of the body according to 1 of 6 treatment sequences listed below. The treatment sequence is repeated for the opposite side of the body for a total of 12 treatment sequences (4 patients in each treatment sequence). The patches are applied to one of 3 body locations for 7 days, for a total exposure period of 21 days, according to one of ...
Throughout human evolution, infectious diseases have been a primary cause of death. Detection of subtle cues indicating sickness and avoidance of sick conspecifics would therefore be an adaptive way of coping with an environment fraught with pathogens. This study determines how humans perceive and integrate early cues of sickness in conspecifics sampled just hours after the induction of immune system activation, and the underlying neural mechanisms for this detection. In a double-blind placebo-controlled crossover design, the immune system in 22 sample donors was transiently activated with an endotoxin injection [lipopolysaccharide (LPS)]. Facial photographs and body odor samples were taken from the same donors when sick (LPS-injected) and when healthy (saline-injected) and subsequently were presented to a separate group of participants (n = 30) who rated their liking of the presented person during fMRI scanning. Faces were less socially desirable when sick, and sick body odors tended to lower ...
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TY - JOUR. T1 - Arterial visualization by contrast-enhanced moving-table MR angiography. T2 - Crossover comparison of 0.1 and 0.2 mmol/kg doses of meglumine gadopentetate in normal volunteers. AU - Hayashi, Hiromitsu. AU - Yuasa, Yuji. AU - Amano, Yasuo. AU - Tanimoto, Akihiro. AU - Saito, Yoko. AU - Yoshioka, Kunihiro. AU - Kita, Miho. AU - Kumazaki, Tatsuo. AU - Hiramatsu, Kyoichi. PY - 2008/9/1. Y1 - 2008/9/1. N2 - Purpose: To determine the appropriate dose of contrast medium for moving-table MR angiography (MT-MRA) from the abdominal aorta to the ankle by comparing visualization with different doses of meglumine gadopentetate (Gd-DTPA) administered in crossover fashion to normal volunteers. Materials and Methods: Twelve healthy adults underwent imaging after crossover administration of 0.1 and 0.2 mmol/kg of Gd-DTPA in random order. Continuous MT-MRA was performed with a fast 3D spoiled gradient echo sequence without parallel imaging technique. Visualization was evaluated in a total of 252 ...
The case-crossover design is suited to medication safety studies but is vulnerable to exposure misclassification. Using the example of tricyclic antidepressants and the risk of hip fracture, we present a data visualisation tool for observing exposure misclassification in case-crossover studies. A case-crossover study was conducted using Australian Government Department of Veterans Affairs claims data. Beneficiaries aged over 65 years who were hospitalised for hip fracture between 2009 and 2012 were included. The case window was defined as 1-50 days pre fracture. Control window one and control window two were defined as 101-150 and 151-200 days pre fracture, respectively. Patients were stratified by whether exposure status changed when control window two was specified instead of control window one. To visualise potential misclassification, each subjects tricyclic antidepressant dispensings were plotted over the 200 days pre fracture. The study population comprised 8828 patients with a median age of 88
Background and aim: Preliminary evaluation of a wild green oat extract (WGOE) (Neuravena® ELFA®955, Frutarom, Switzerland) revealed an acute cognitive benefit of supplementation. This study investigated whether regular daily WGOE supplementation would result in sustained cognitive improvements. Method: A 12-week randomised, double-blind, placebo-controlled cross-over trial of WGOE supplementation (1500 mg/day) versus placebo was undertaken in 37 healthy adults aged 67 ± 0.8 years (mean ± SEM). Cognitive assessments included the Stroop colour-word test, letter cancellation, the rule-shift task, a computerised multi-tasking test battery and the trail-making task. All assessments were conducted in Week 12 and repeated in Week 24 whilst subjects were fasted and at least 18 h after taking the last dose of supplement. Result: Chronic WGOE supplementation did not affect any measures of cognition. Conclusion: It appears that the cognitive benefit of acute WGOE supplementation does not persist with chronic
Background: The prevention and treatment of obesity is a public health challenge. Objective: We investigated the effects of dietary composition, insulin sensitivity (SI), and energy balance on predicted changes in body composition. Design: In a randomized crossover design study, 39 normal-weight (n = 23), overweight (n = 8), and obese (n = 8) men and women (aged 25-36 y) each followed a 15-d isocaloric high-fat (HF; 50% fat) and high-carbohydrate [HC; 55% carbohydrate (CHO)] diet with a 4-6-wk washout period during the first year. During each treatment, energy balance was measured while the subjects were inactive by using indirect calorimetry on day 15, and S I was measured by using a euglycemic clamp study (40 mU · m-2· min-1) on day 16. Weight and body composition were then measured annually for 4 y. The outcomes for fat mass, percentage body fat, and weight were measured by using a linear 2-stage mixed model. Results: CHO balance (day 15) and SI (day 16) on the HC diet were highly and ...
This study used a multicenter, randomized, prospective, controlled, open-label, two-period crossover design. Individuals who were routinely treated with intensive, multi-injection insulin therapy using regular human or rapid-acting insulin and insulin glargine were recruited.. The participants entered a 2-week screening period, and if the acceptance criteria were satisfied and written informed consent was given, they were randomly assigned by means of a computer-generated blind random process to one of four cohorts. The first 3-week treatment phase consisted of insulin administration either by SI, a single I-Port device, or two separate I-Port devices (Dual I-Port). Using a two-period crossover design, the participants were reassigned to an alternate treatment regimen for an additional 3 weeks as indicated in Figure 2.. All regimens administered regular human or rapid-acting insulin and insulin glargine, a minimum of two injections daily of either Novolin, Humulin, NovoLog, Humalog, or Apidra ...
Adenosine might provoke bronchospasm in certain susceptible patients such as those with asthma or those on maintenance doses of bronchodilators or steroids. The selectivity of regadenoson was therefore of great interest to study for its safety and efficacy in such patients. The final answer is not yet in, and more studies are needed, but there are some preliminary data.. Prior studies have suggested that with prophylactic pre-treatment with a B-2 agonist, adenosine could be given to patients with mild asthma or chronic obstructive lung disease (COPD). It should be noted the majority of patients with COPD but no bronchospasm could be tested with adenosine without any serious problem (39). Further, tachypnea is common after adenosine infusion and is not due to changes in airway resistance or pulmonary capillary wedge pressure but rather to stimulation of carotid body receptors (40,41).. A randomized double-blind, placebo-controlled cross-over trial assessed the safety of regadenoson in 48 patients ...
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The study design is two-period crossover study (repeated measures design) . Participants will complete two trials of 3-minutes pre-oxygenation via non-rebreather mask (NRM)., One trial will have an oxygen flow rate of 15lpm, The other will have the flow-meter valve turned wide open. The end-tidal oxygen (ETO2) will be measured at the end of each trial. The first trial will be followed by a washout period of 2 minutes. Allocation to the first trial (15lpm or fully open valve) will be randomised. ...
Jaguar has announced it will showcase a new design study based on the F-Type convertible at this weekends Goodwood Festival of Speed. The F-Type show car will be joined at the annual event by Jaguars latest crop of performance vehicles. Jaguar...
Passive Tomography for Spent Fuel Verification: Analysis Framework and Instrument Design Study. Proceedings of 37th ESARDA Symposium on Safeguards and Nuclear Non-Proliferation, Manchester, UK, 19-21 May 2015. pp 949- ...
Fingerprint Dive into the research topics of A phase II randomised (calibrated design) study on the activity of the single-agent trabectedin in metastatic or locally relapsed uterine leiomyosarcoma. Together they form a unique fingerprint. ...
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40+/-11 vs. 45+/-9%, P=0.02), a smaller ...
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40+/-11 vs. 45+/-9%, P=0.02), a smaller ...
Background: Abediterol is a novel, once-daily LABA under development for the treatment of asthma and COPD. The peak bronchodilator effect of single doses of abediterol delivered via Genuair® vs placebo was assessed against salbutamol 400 µg in patients with persistent stable asthma.. Methods: Adult patients were randomized to receive abediterol (0.313, 0.625, 1.25 or 2.5 μg), salbutamol 400 μg and placebo in a 6-period crossover study. Endpoints included change from baseline to peak (primary endpoint) and trough FEV1 and FVC. Safety was also assessed.. Results: A total of 58/62 randomized patients completed the study. Abediterol (all doses) and salbutamol achieved clinically and statistically significant improvements from baseline in peak FEV1 vs placebo (p,0.0001; Table). Peak FEV1 magnitude of effect with abediterol (all doses except 0.313 μg) was similar to salbutamol. Abediterol had a dose-dependent and significantly greater effect on trough FEV1 vs placebo (p,0.0001) and vs salbutamol ...
Resilience or the ability of our body to cope with daily-life challenges has been proposed as a new definition of health, with restoration of homeostasis as target resultant of various physiological stress responses. Challenge models may thus be a sensitive measure to study the bodys health. The objective of this study was to select a dietary challenge model for the assessment of inflammatory resilience. Meals are a challenge to metabolic homeostasis and are suggested to affect inflammatory pathways, yet data in literature are limited and inconsistent. The kinetic responses of three different dietary challenges and a water control challenge were assessed on various metabolic and inflammatory markers in 14 healthy males and females using a full cross-over study design. The dietary challenges included glucose (75 g glucose in 300 ml water), lipids (200 ml whipping cream) and a mix of glucose and lipids (same amounts as above), respectively. Blood samples were collected at baseline and at 0.5, 1, 2, 4, 6,
PURPOSE: To examine the effects of static and dynamic stretching routines performed as part of a comprehensive warm-up on flexibility and sprint running, jumping and change of direction tests in team sport athletes. METHODS: A randomized, controlled, cross-over study design with experimenter blinding was conducted. On separate days, 20 male team sport athletes completed a comprehensive warm-up routine. After a low-intensity warm-up a 5-s static stretch (5S), 30-s static stretch (30S; 3×10-s stretches), 5-repetition (per muscle group) dynamic stretch (DYN) or no stretch (NS) protocol was completed; stretches were done on 7 lower body and 2 upper body regions ...
CARGO study (Copeptin after arginine infusion in the diagnosis of polyuria polydipsia syndrome): observational study evaluating the value of arginine infusion and copeptin measurements in the differential diagnosis of polyuria polydipsia syndrome CARGOx study (Copeptin after arginine infusion compared to copeptin after hypertonic saline infusion for the differential diagnosis of diabetes insipidus) GOLD study (Effects of GLP-1 analogues on fluid intake in patients with primary polydipsia): randomized placebo-controlled cross-over study evaluating the effect of GLP-1 analogs on fluid intake in patients with primary polydipsia GATE study (Effects of GLP-1 and analogues on fluid intake in healthy volunteers): randomized placebo-controlled cross-over study evaluating the effect of GLP-1 analogs on fluid intake in healthy volunteers SAND study (SGLT-2 inhibitors for treatment of SIADH, a placebo-controlled randomised study) HIT study (Hyponatremia Intervention study) COMEN study (Copeptin in ...
OSU6162 caused a remarkable improvement in mental stamina, as evaluated by a self-assessment scale on mental fatigue. Statistical significance was reached on the primary endpoint (Mental Fatigue Scale). There was a trend towards improvement in the secondary endpoints processing speed and attention. Principal component analysis showed an overall positive treatment effect in 7 of 12 patients. Beneficial responses were seen already during the first few days of active drug treatment. Increasing dosage caused no further improvement. Adverse reactions consisted of short-lasting mild nausea and attenuated appetite. These side effects disappeared upon dose reduction. ...
TY - JOUR. T1 - A double-blind evaluation of skin test suppression produced by two doses of terfenadine. AU - Bantz, Eric W.. AU - Dolen, William K.. AU - Nelson, Harold S.. PY - 1987/1/1. Y1 - 1987/1/1. N2 - For some patients, terfenadine, in the currently recommended dose of 60 mg twice daily (bid), may be only modestly effective in the treatment of allergic rhinitis. In a double-blind placebo-controlled crossover study of 12 patients, a larger dose (300 mg bid) was evaluated for its suppression of titrated skin tests to histamine and compound 48/80 to determine whether this regimen might result in greater suppression while it maintained the freedom from side effects of the presently recommended dose. In seven patients, skin test suppression by these two doses of terfenadine, each administered for 3 days, was compared to that produced in an earlier study by 3 days of treatment with chlorpheniramine (8 mg three times a day). The 300 mg bid terfenadine regimen produced significantly greater skin ...
Cross Over Ministries and the Hillsboro Presbyterian Church are collaborating to bring DivorceCare for Kids (DC4K) to Hillsboro. The 13-week program will be held each Monday from 6:30 to 8:30 p.m., Monday, Sept. 9, through Monday, Dec. 2. While held in Hillsboro, the program is open to any child age five through 12 years old, and their parents, who are in need of the ministry-based service.. Spearheaded by Cross Over Ministries volunteer Lynette Weiss, the program organizers hope to bring much needed healing to area children and parents affected by divorce. Weiss, a child of divorce herself, had gone through a similar program alongside her son, following her own divorce. The closest DC4K program was in Springfield and Weiss made the weekly commutes to attend knowing the benefits it would have for her family. While titled divorce care, the program is for children going through any kind of family fragmentation whether the upheaval is due to divorce, incarceration, addiction or other factors. The ...
Background In the context of personalized cancer care, patients (pts) should receive the therapy that best meets their needs while optimizing the use of healthcare resources. A budget impact model was developed to compare each of the most commonly used mCRC treatment sequences - from 1st line to 3rd line in a Canadian context.. Methods This Excel based model considers the price of each agent, the number of cycles per treatment course, the relative dose intensity of the regimens to determine the cost of the most commonly used mCRC therapies and calculates the costs per overall sequence from 1st line to 3rd line. It takes into account the percentage of pts who benefit from a R0 resection post 1st line chemotherapy and who forego subsequent treatments. Factors such as different percentage use of 1st line FOLFOX vs FOLFIRI and pts volumes per line of therapy are considered in this model. Users can choose the scenarios they would like to examine. Key variables can be extracted through expert ...
Take Part in the Simulation Driven Design Study NAFEMS invites you to participate in the Simulation Driven Design study, being conducted by Lifecycle Insights by completing a short survey. For more than a decade now, engineering organizations have been pushing to use simulation to help make design decisions, not just validate them. But how far have we come? How far do we have left to go? The study aims to answer that exact question. It includes questions on the setup, solve, review and management of s
Background: We investigated vascular and metabolic responses to ramipril and candesartan therapies either alone or in combination in hypertensive patients.. Methods: This was a randomized, double-blind, placebo-controlled cross-over trial with three treatment arms (each 2 months) and two washout periods (each 2 months). Thirty-four patients were given ramipril 10 mg and placebo, ramipril 10 mg and candesartan 16 mg, or candesartan 16 mg and placebo daily during each 2 month treatment period.. Results: Ramipril, combined therapy, or candesartan significantly reduced blood pressure after 2 months administration compared with baseline. All three treatment arms did not significantly change the lipoprotein profile. All three treatment arms significantly improved flow-mediated dilator response to hyperemia. However, combined therapy significantly reduced blood pressure and improved flow-mediated dilation to a greater extent than ramipril or candesartan alone (all P,0.001 by ANOVA). Interestingly, only ...
The aim of this study was to investigate postprandial effects of two Chinese liquors on s elected cardiovascular disease risk factors in humans. Sixteen healthy men were randomized into three groups in a three-way crossover study: tea-flavor liquor (TFL), traditional Chinese liquor (TCL) and water control (WC). Every subject consumed 60 mL of either liquor (45% (v/v) ethanol) or water together with a high-fat meal, respectively. Compared with baseline, serum uric acid was significantly increased in TFL group (0.5-hour: P = 0.012; 1-hour: P = 0.001; 2-hour: P = 0.008) and it was significantly decreased in WC group (1-hour: P = 0.001; 2-hour: P = 0.001; 4-hour: P | 0.001), while uric acid was non-significantly increased in the TCL group. High-sensitive C-reactive protein (hs-CRP) was significantly increased in the TCL (P = 0.014) and WC (P = 0.008) groups at postprandial 4 hours compared with baseline. There was no significant difference between groups during the postprandial period for these two
Abstract Background. Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain. Specificity of relief is unclear because different neural pathways may account for different components of clinical dyspnoea. Our objective was to evaluate if inhaled furosemide relieves the air hunger component (uncomfortable urge to breathe) but not the sense of breathing work/effort of dyspnoea. Methods. A randomised, double blind, placebo-controlled crossover trial in 16 healthy volunteers studied in a university research laboratory. Each participant received 3 mist inhalations (either 40 mg furosemide or 4 ml saline) separated by 30-60 min on 2 test days. Each participant was randomised to mist order furosemide-saline-furosemide (n- = 8) or saline-furosemide-saline (n = 8) on both days. One day involved hypercapnic air hunger tests (mean ± SD PCO2 = 50 ± 3.7 mmHg; constrained ventilation = 9 ± 1.5 L/min), the ...
Fifteen out of 18 pink and puffing patients completed a double-blind, placebo-controlled cross-over trial of diazepam and promethazine for breathlessness and reduced exercise tolerance. Dosages were 25 mg and 125 mg daily, respectively, and each co
Purpose: This study investigated the effect of dual bronchodilation with the long-acting β-receptor agonist/long-acting muscarinic antagonist combination, indacaterol/glycopyrronium (IND/GLY), on nighttime oxygenation, lung function, sleep quality, and symptoms in patients with moderate-to-severe COPD. Patients and methods: This was a 4-week, double-blind, multicenter, placebo-controlled, two-period crossover study. Patients were randomized in a 1:1 ratio to receive IND/GLY 110/50 µg once daily or matching placebo. The primary objective was to evaluate the effect of treatment with IND/GLY on mean nighttime oxygenation, compared with placebo. The secondary objective was to determine the time spent ,90% in blood oxygen saturation (SpO2) compared with placebo. Exploratory objectives were to assess the effect of IND/GLY, compared with placebo, on sleep quality measured by the Medical Outcomes Study (MOS) Sleep Scale and the COPD and Asthma Sleep Impact Scale (CASIS) questionnaires and on symptoms ...
Background: The positive effect of carbohydrates from commercial beverages on soccer-specific exercise has been clearly demonstrated. However, no study is available that uses a home-mixed beverage in a test where technical skills were required. Methods: Nine subjects participated vol-untarily in this double-blind, randomized, placebo-controlled crossover study. On three testing days, the subjects performed six Hoff tests with a 3-min active break as a preload and then the Yo-Yo Intermittent Running Test Level 1 (Yo-Yo IR1) until exhaustion. On test days 2 and 3, the subjects received either a 69 g carbohydrate-containing drink (syrup-water mixture) or a carbo-hydrate-free drink (aromatic water). Beverages were given in several doses of 250 mL each: 30 min before and immediately before the exercise and after 18 and 39 min of exercise. The primary target parameters were the running performance in the Hoff test and Yo-Yo IR1, body mass and heart rate. Statistical differences between the variables of both
TY - JOUR. T1 - Endovascular crossing of Chronic Total Occlusions using an impulse. T2 - An explorative design study. AU - Sakes, Aimée. AU - van der Wiel, Marleen. AU - Dodou, Dimitra. AU - Breedveld, Paul. PY - 2017. Y1 - 2017. N2 - In this study we investigated whether exerting an impulse on a Chronic Total Occlusion (CTO) improves the success rate of CTO crossing as compared to the currently used method of statically pushing the guidewire against the CTO. A prototype (Ø2 mm) was developed that generates translational momentum using a spring-loaded indenter and converts it to an impulse during impact. Mechanical performance was evaluated by measuring the peak force and momentum for different spring compressions and strike distances in air and blood-mimicking fluid. Puncture performance, in terms of number of punctures, number of strikes to puncture, and energy transfer from the indenter to the CTO, was assessed for six tip shapes (stamp, wedge, spherical, pointed, hollow spherical, and ...
The purpose of this study was to determine the effect of stand-biased desks on the physical activity and sedentary behavior of third, fourth and sixth grade students across the school year. Methods: This within classroom crossover design study used teacher-determined allocation for seating within each classroom. Half of the students used a stand-biased desk and half used a sitting desk. Five-day hip-worn accelerometer assessments were completed at baseline and at the end of each nine-week intervention period. A mixed effects model was used to determine the differences in the percentage of time spent active and sedentary. Results: A total of 22, 36 and 41 students in 3rd, 4th and 6th grades, respectively, completed this study (57.1% male, 79.3% White). Regardless of the desk type, students became more sedentary (p < 0.001) and less active (p < 0.001) in the classroom as the school year progressed. After controlling for baseline activity, there was a significant interaction between the type of desk
To examine the clinical role of BAYm 1099, 15 diettreatednon-insulin-dependent diabetic (NIDDM) subjects were randomized to start drug (50 mg 3 times/ day) or placebo after a 4-wk run-in period in a doubleblind crossover study. Treatment periods (4 wk) were separated by a 2-wk washout period. During the last week of each treatment period, three test meals (TMs) were administered: 60 g starch (TM1), 25 g sucrose (TM2), and combined 60 g starch and 25 g sucrose (TM3). Twelve subjects completed the study. The peak postprandial blood glucose, lactate, and pyruvate levels (means ± SE) were significantly lower with active drug after all test meals, particularly TM2 (11.3 ±1.0 vs. 14.3 ± 1.4 mM, P ,.001; 1.53 ± 0.20 vs. 2.48 ± 0.17 mM, P , .001; and 105.1 ± 17.6 vs. 147.6 ± 11.1 μM, P , .05, respectively. Peak blood glucose levels were significantly delayed. However, fasting blood glucose, HbA1, fructosamine, and cholesterol did not change during active treatment (10.0 ±1.0 vs. 9.9 ±1.0 mM, ...
AIMS/HYPOTHESIS: Glitazones are powerful insulin sensitisers prescribed for the treatment of type 2 diabetes. Their use is, however, associated with fluid retention and an increased risk of congestive heart failure. We previously demonstrated that pioglitazone increases proximal sodium reabsorption in healthy volunteers. This study examines the effects of pioglitazone on renal sodium handling in individuals prone to insulin resistance, i.e. those with diabetes and/or hypertension. METHODS: In this double-blind randomised placebo-controlled four-way crossover study, we examined the effects of pioglitazone (45 mg daily during 6 weeks) or placebo on renal, systemic and hormonal responses to changes in sodium intake in 16 individuals, eight with type 2 diabetes and eight with hypertension ...
We are only 10 minutes walk from Leeds train station. Exit the station and follow the way out to City Square. Cross over two sets of pedestrian crossings and proceed forward across City Square. After City Square turn left onto Infirmary Street, at the end of this road, cross over the pedestrian crossing to the right and then cross over the pedestrian crossing to the immediate left. This will bring you to St Pauls Street. Continue along St Pauls Street for approximately 150 yards and then turn right at Park Square East. This will bring you onto Park Square and the clinic is situated on the far side of the park. The main shopping district is only 10 minutes walk from the clinic. ...
An implantable arrhythmia treatment system includes a sensor which generates an electrical signal corresponding to a physiological characteristic of a patient, the physiological characteristics and thus the electrical signal exhibit a change given the onset of an arrhythmia. The electrical signal is supplied to a fibrillation detector in an implantable housing, which initiates an appropriate treatment sequence upon the detection of the onset of the arrhythmia. Simultaneously with initiating the treatment sequence, the fibrillation detector causes, either by direct connection or by telemetry communication, the generation of an alarm signal which informs the patient that the sequence has been initiated, so that the patient knows that a treatment pulse is about to be released. The implantable unit includes circuitry responsive to a signal externally generated by the patient which prevents the release of the defibrillating pulse. If the patient feels no need for such a pulse, i.e. if the onset of the
23 March 2018. Australian researchers have greater clarity on the best course of treatment for patients with advanced melanoma which has spread to the brain.. Results from a clinical trial, developed and run by investigators at Melanoma Institute Australia and published today in the Lancet Oncology, demonstrate that a combination of immunotherapies are most active in patients with asymptomatic brain metastases who have not previously been treated.. The Phase II trial known as the Anti-PD1 Brain Collaboration (ABC) trial involved advanced melanoma patients being given either a combination of two immunotherapy drugs (nivolumab [Opdivo®] and ipilimumab [Yervoy®]) or single therapy (nivolumab alone).. The results from the trial suggest that patients with asymptomatic brain metastases who have not received any prior targeted therapy (e.g. MEK or BRAF inhibitors) have a high chance of long-term response to treatment. Response rates were less effective in patients who had already been treated with ...
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Caffeine (CAF) supplementation could have a positive impact on physical performance and sport abilities. Nevertheless, the CAF-induced, dose-dependent influence on discipline-specific performance and combat activity in combat sports have not been sufficiently investigated. The aim of this study was to examine the effect of single ingestion of 3, 6, or 9 mg/kg body weight of CAF and placebo (PLA) on judo-specific performance and sparring combat activities. In a randomised double-blind placebo-controlled cross-over design, acute pre-exercise supplementation with CAF (3, 6, or 9 mg/kg body weight) and placebo PLA in 22 male highly-trained judoists was examined. The study protocol involved five separate testing sessions using the Special Judo Fitness Test (SJFT) with heart rate monitoring, three judo sparring combats and evaluation of the rate of perceived exertion (RPE) using the Borg scale. Six and 9 mg/kg CAF improved SJFT performance, while 9 mg/kg increased combat activity. Three mg/kg CAF lacked any
An Open-label, Randomized, 2-period Crossover Study to Compare the Pharmacokinetic Bioequivalence of a Single 210 mg Dose of Brodalumab Administered to Healthy Subjects by Subcutaneous Injection Using a Prefilled Syringe and an Autoinjector ...
Strenuous aerobic exercise is known to weaken the immune system, and while many nutritional supplements have been proposed to boost post-exercise immunity, few are known to be effective. The purpose of the present study was to evaluate whether 10 d of supplementation with a defined source of bakers yeast β-glucan (BG, Wellmune WGP®) could minimise post-exercise immunosuppression. Recreationally active men and women (n 60) completed two 10 d trial conditions using a cross-over design with a 7 d washout period: placebo (rice flour) and bakers yeast BG (250 mg/d of β-1,3/1,6-glucans derived from Saccharomyces cerevisiae) before a bout of cycling (49 ± 6 min) in a hot (38 ± 2°C), humid (45 ± 2 % relative humidity) environment. Blood was collected at baseline (before supplement), pre- (PRE), post- (POST) and 2 h (2H) post-exercise. Total and subset monocyte concentration was measured by four-colour flow cytometry. Plasma cytokine levels and lipopolysaccharide (LPS)-stimulated cytokine ...
The authors report 4 experiments that examined color grouping and negative carryover effects in preview search via a probe detection task (J. J. Braithwaite, G. W. Humphreys, & J. Hodsoll, 2003). In Experiment 1, there was evidence of a negative color carryover from the preview to new items, using both search and probe detection measures. There was also a negative bias against probes on old items that carried the majority color in the preview. With a short preview duration (150 ms) carryover effects to new items were greatly reduced, but probe detection remained biased against the majority color in the old items. Experiments 2 and 4 showed that the color bias effects on old items could be reduced when these items had to be prioritized relative to being ignored. Experiment 3 tested and rejected the idea that variations in the probability of whether minority or majority colors were probed were crucial. These results show that the time course of color carryover effects can be separated from effects of
A double-blind, three way randomized cross-over clinical trial was conducted in which each participant served as his/her own control. After fasting overnight for at least 10 hours, participants were randomly given 300ml servings of three beverages containing 50g glucose, sucrose and lacritose. Blood samples were collected before and afterwards every 30 minutes for up to 2 hours ...
We failed to prove our hypothesis that administration of psyllium in the morning would have a greater cholesterol-lowering effect than it would in the evening. Not only was there no observable difference in lipid levels between the crossover periods but the daily ingestion of a greater daily dose than the 10.2 g of psyllium for which the FDA allows health claims to be made [6] had no effect on lipid levels in our study group. No change in any lipid parameter, including total and LDL cholesterol was observed. No difference was found when subgroup analysis was undertaken for the sex of the patients, the time of day they took their psyllium, or whether they were recruited from the gastroenterology clinic or the lipid clinic.. We used a crossover design since this was the most appropriate one for the primary question being addressed; accordingly, our study did not include a control group. However, the nature of the study should not have provided any motivation for study subjects to adopt any new ...
PubMed journal article Postprandial platelet aggregation: effects of different meals and glycemic inde were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
TY - JOUR. T1 - Enhancement of abdominal structures on MRI at 1.5 and 3 T. T2 - European Radiology. AU - AlObaidy,Mamdoh. AU - Ramalho,Miguel. AU - Velloni,Fernanda. AU - Matos,António P.. AU - Herman,Kevin. AU - Semelka,Richard C.. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Objective: To quantitatively compare the extent of enhancement of abdominal structures on MRI in an intraindividual fashion at 1.5 and 3 T. Methods: HIPAA-compliant, retrospective, longitudinal, intraindividual, crossover study, with waived informed consent, of consecutive individuals scanned at both 1.5 and 3 T closed-bore magnets using gadobenate dimeglumine during different phases of enhancement at tightly controlled arterial phase timing. Quantitative ROI measurements and qualitative sub-phase arterial phase assignments were independently performed by two radiologists. Qualitative discrepancies were resolved by a senior radiologist. Results: Final population included 60 patients [41 female and 19 male; age, 49.35 ± 18.31 years ...
On the other hand, in molecularly selected populations for whom targeted therapies are tested, our ability to detect an OS advantage is severely attenuated by the effects of crossover. In the EURTAC clinical trial, patients with activating mutations in EGFR were treated with targeted therapy with erlotinib (23). This was associated with a 4-month prolongation in PFS, but no benefit in OS (Fig. 3). Seventy-seven percent of patients on the chemotherapy arms of these trials went on to receive EGFR-targeted therapy at the time of progression. Four points are underscored by this clinical trial: (i) crossover is a critical component of clinical trial design both as an ethical necessity and a tool for investigators to maximize accrual; (ii) not every patient in a clinical trial has the opportunity to cross over to the targeted agent (in this trial 23% patients did not cross over), as is the case with patients who have rapid progression of their disease whose performance status might preclude further ...