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We note with interest the further correspondence concerning the systematic review of inhaled sodium cromoglycate as maintenance therapy in children with asthma1 from Professor M Silverman2 and Dr G Laszlo.3. Professor Silverman asked the authors to carry out separate calculations of the size of the treatment effect between inhaled sodium cromoglycate and placebo for school children and pre-school children. The results of these calculations show that the mean difference between inhaled sodium cromoglycate and placebo is greater for school children (cough 0.26, wheeze 0.29) than for pre-school children (cough 0.12, wheeze 0.08). In both age groups these differences are significant and in favour of sodium cromoglycate. In fig 1 we illustrate these differences and the comparison with all children taken from the original review.. These results support our own conclusion4 that the drug is either less effective in pre-school children or the apparent lesser effect is related to the difficulties in ...
TY - JOUR. T1 - Inhibitory effect of nifedipine and cromolyn sodium on skin reactions and 45ca uptake and histamine release in rat mast cells induced by various stimulating agents. AU - Tanizaki, Yoshiro. AU - Akagi, Katsumi. AU - Lee, Kyung Nam. AU - Townley, Robert G.. PY - 1983. Y1 - 1983. N2 - The effect of nifedipine, one of the calcium channel antagonists, was examined in allergic and nonspecific reactions using rat skin and peritoneal mast cells. Rat passive cutaneous anaphylaxis response mediated by IgE antibody was inhibited by nifedipine (100 μg/rat) and also by cromolyn sodium (5 mg/rat). Skin reactions induced by histamine or methacholine were not inhibited, and skin reaction induced by serotonin was slightly inhibited by these drugs. The 45Ca uptake and histamine release in sensitized mast cells stimulated by ovalbumin were suppressed by nifedipine. In actively sensitized cells, nifedipine seems to be more effective on the inhibition of 45Ca uptake, but less effective on histamine ...
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Cromolyn sodium Inh Soln (Cromolyn) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
The overall purpose of this project is to develop and validate a simple, non-invasive method to detect aspiration of gastro-intestinal fluid into the respiratory tract. In the inpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 4 ingestions (at 2h intervals) of a 200 mL of a 1mg/mL solution of cromolyn sodium, by 5 healthy control subjects and 5 patients (3-6 with pulmonary fibrosis; and 3-6 either awaiting or recently undergone lung transplantation) with clinical and laboratory evidence of GER (gastroesophageal reflux) with microaspiration. In the outpatient setting, the investigators will compare the quantity of cromolyn detected in urine collected overnight after 1 ingestions (at 4h intervals) of a 200 mL of a 1mg/mL solution of cromolyn sodium, by 10 patients (3-6 with pulmonary fibrosis; and 3-6 either awaiting or recently undergone lung transplantation) with clinical and laboratory evidence of GER (gastroesophageal reflux) ...
Leflein JG, Szefler SJ, Murphy KR, Fitzpatrick S, Cruz-Rivera M, Miller CJ, Smith JA. Nebulized budesonide inhalation suspension compared with cromolyn sodium nebulizer solution for asthma in young children: results of a randomized outcomes trial. Pediatrics. 2002 May; 109(5):866-72 ...
Mansour, H., Xu, Z., & Hickey, A. (2007). Characterization of dry powder aerosols of albuterol sulfate and cromolyn sodium with various sugar carriers delivered by standardized entrainment tubes. The AAPS Journal, 9(4), W - 5234 ...
Of 3500 titles retrieved from the literature, 24 papers reporting on 23 studies could be included in the review. The studies were published between 1970 and 1997 and together included 1026 participants. Most were cross-over studies. Few studies provided sufficient information to judge the concealment of allocation. Four studies provided results for the percentage of symptom-free days. Pooling the results did not reveal a statistically significant difference between sodium cromoglycate and placebo. For the other pooled outcomes, most of the symptom-related outcomes and bronchodilator use showed statistically significant results, but treatment effects were small. Considering the confidence intervals of the outcome measures, a clinically relevant effect of sodium cromoglycate cannot be excluded. The funnel plot showed an under-representation of small studies with negative results, suggesting publication bias.. ...
BACKGROUND: This is an update of a review last published by Cochrane in June 2012 entitled "Cromolyn sodium for the prevention of chronic lung disease in preterm infants", which included two studies. This 2016 update identified no further studies.Chronic lung disease (CLD) frequently occurs in preterm infants and has a multifactorial aetiology including inflammation. Cromolyn sodium is a mast cell stabiliser that inhibits neutrophil activation and neutrophil chemotaxis and therefore may have a role in the prevention of CLD. OBJECTIVES: To determine the effect of prophylactic administration of cromolyn sodium on the incidence of CLD at 28 days or 36 weeks postmenstrual age (PMA), mortality, or the combined outcome of mortality and CLD at 28 days or 36 weeks PMA in preterm infants. SEARCH METHODS: We used the standard search strategy of Cochrane Neonatal to search the Cochrane Central Register of Controlled Trials (CENTRAL 2016, Issue 4), MEDLINE via PubMed (1966 to 12 May 2016), Embase (1980 to ...
Cromoglicic acid (INN) (also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate) is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium. This drug prevents the release of inflammatory chemicals such as histamine from mast cells. Because of their convenience (and perceived safety), leukotriene receptor antagonists have largely replaced it as the non-corticosteroid treatment of choice in the treatment of asthma. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids. Cromolyn sodium was discovered by Roger Altounyan who was himself a lifelong asthma sufferer. It is considered a breakthrough drug in management of asthma, as the patients can be freed from steroids in many cases; however, it is mainly effective as a prophylaxis for allergic and exercise-induced asthma, not as a treatment for acute attacks. ...
Cromone therapy is thought to inhibit IgE-dependent histamine release from mast cells, although the effects of sodium cromoglycate on human lung mast cells are weak. Both agents have weak effects on eosinophils and on macrophage activity but do not affect airway smooth muscle tone.
Other. Regions Wise Cromoglycate Sodium Market Analysis:. - North America (United States, Canada, Mexico). - South America (Brazil, Argentina, Peru, Chile). - Southeast Asia (Japan, Korea, India, China). - Middle East & Africa (Egypt, Saudi Arabia, Turkey, South Africa). - Europe (Germany, France, United Kingdom, Italy, Russia). Inquire for Any Queries or Information Related About Report (Use Corporate email ID to Get Higher Priority): https://market.us/report/cromoglycate-sodium-market/inquiry. Salient Features of the Global Cromoglycate Sodium Market Report:. Comprehension of contemporary and potential Cromoglycate Sodium market trends, dynamics, and growth drivers.. Extensive delineation of Cromoglycate Sodium market scope, potential, limitations, and restraints.. Thorough insights into leading Cromoglycate Sodium market competitors alongside detailed corporate profiles.. Investigation of rivalry landscape to gain substantial competitive advantages.. Precise vision to manage upcoming ...
The review of placebo controlled trials of sodium cromoglycate (SCG) in childhood asthma by Tasche et al 1 concludes that "there is insufficient evidence that SCG has a beneficial effect as maintenance treatment in children with asthma".. We do not believe this conclusion is justified. The principal criteria for assessing the efficacy of inhaled SCG are the mean differences in the effect on the symptoms of cough and wheeze between SCG and placebo across all trials included in the review. The 95% confidence intervals for these differences are 0.12 to 0.27 for cough and 0.11 to 0.26 for wheeze. As the differences are in favour of SCG and the confidence intervals do not include zero, the only conclusion that can be drawn is that there is strong statistical evidence for a beneficial effect of SCG in children with asthma-the reverse conclusion to that presented.. The review identified 24 randomised controlled trials and is claimed to include "all published randomised, placebo controlled trials". Two ...
Learn more about Allergan Opticrom Sodium Cromoglycate Ophthalmic Solution 2% W/V 10mL in Eye Care, Everyday Medicines & First Aid with Pharmaprix
This is a special ordered item. This product must be paid for upon ordering. It cannot be returned. It is non-refundable and non-returnable. Mast cell stabilizer indicated n the treatment f vernal keratoconjunctivitis, vernal conjunctivitis and vernal keratitis. (Compare to Crolom).
Description of the drug Cromolyn Nebulizer Solution. - patient information, description, dosage and directions. What is Cromolyn Nebulizer Solution!
There is described a method of treatment of asthma which comprises administration to an asthmatic patient of an effective amount of an inhalation composition consisting essentially of a dispersion or suspension of from 0.2 to 2.0% disodium cromoglycate of mass median diameter 0.01 to 10 microns, from 0.15 to 2.0% by weight of a sorbitan or sorbitol ester surfactant and a propellant mixture comprising dichlorodifluoromethane and 1,2-dichloro-1,1,2,2-tetrafluoroethane, the ratio of dichlorodifluoromethane to 1,2-dichloro-1,1,2,2-tetrafluoroethane, in said mixture being in the range from 2:1 to 1:1 by weight, the disodium cromoglycate used in the formulation containing from 0.05 to 1% w/w of water and the total formulation containing less than 0.1% w/w of water and having a vapor pressure in the range 35 to 70 pounds per square inch gauge. There is also described disodium cromoglycate having a mass median diameter of less than 20 microns, more preferably in the range 0.01 to 10 microns, and most preferably
Another category of anti-allergic drugs are cromones . It is a Mediterranean plant-derived products (Amni Visnaga) for local application that are administered as eye drops or nasal spray or aerosol sprays for the bronchi. Their action is to prevent the release of histamine and other irritants that would be released from special cells ( mast cells ) during allergic stimuli. The cromones are cromolyn sodium and the most recent sodium nedocromil . These also act when administered before contact with the allergen, and that is why their main use is in the prophylactic treatment of bronchial asthma , and only the sodium cromoglycate in the food allergies ...
Nebulisers are machines that turn the liquid form of your short-acting bronchodilator medicines into a fine mist, like an aerosol. You breathe this in with a face mask or a mouthpiece. Nebulisers are no more effective than normal inhalers. However, they
Visit your doctor or health care professional for regular check ups as directed. Tell your doctor or health care professional if your symptoms do not start to get better within 1 to 2 weeks or if they get worse.. You may use other allergy medicines with this medicine, if needed. Ask your doctor or health care professional for advice.. Do not share this bottle with anyone else as this may spread germs.. ...
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The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE ...
English-language studies were selected if they were randomized, double-blind, placebo-controlled trials of inhaled DSCG in the maintenance treatment of asthma in children up to 18 years of age. Studies of exercise-induced asthma were excluded ...
Ryo, U.Y.; Kang, B.; Townley, R.G., 1976: Cromolyn therapy in patients with bronchial asthma. Effect on inhalation challenge with allergen, histamine, and methacholine
It is used for relieving the eye symptoms of allergies such as hay fever (allergic conjunctivitis). Before using these eyedrops, tell yoir doctor wether you have ever had any allergic reaction towards any eye drops. Before useing these drops, one should first wash his hands first. Never share a bottle of eye drops with another person because it can lead to eyeinfections. Mild eye irritation such as burning or stinging, blurred vision may occuras side effects. Try as smuch as possible to keep medicine out of childrens reach.
Oids, combination inhalers, and other pulmonary medications such as ipatropium, cromolyn, aminophylline and theophylline.Identification of Sepsis EventsWe
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children- Although there is no specific information comparing the use of cromolyn in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. The inhalation solution form of this medicine should not be used in children younger than 2 years of age, and the inhalation aerosol should not be used in children younger than 5 years of age. Older adults- Many medicines have ...
This eMedTV resource explains how you can help ensure the effectiveness of cromolyn inhalation by telling your doctor about any other drugs you are taking and any other medical conditions you have. This page also describes how this drug works.
Easy to read patient leaflet for Cromolyn Capsules. Includes indications, proper use, special instructions, precautions, and possible side effects.
select /*+ index(customs_tariff_heading,description_of_goods,port_of_destination,country_code,indian_Port,unit_quantity_code,file_date) */ SQL_CALC_FOUND_ROWS id,port_of_destination as port_of_destination,description_of_goods,customs_tariff_heading,quantity,unit_quantity_code,country_code,value_of_goods_in_rupees,indian_Port,unit_value,date_format(file_date,%d-%b-%y) as date_time from eximpuls_export.export_master where 1=1 and match(description_of_goods)Against(+Cromolyn +Sodium IN BOOLEAN MODE) order by sort_date desc limit 50 offset ...
WASHINGTON - Dey Inc., Dey Pharma L.P. (formerly known as Dey, L.P.) and Dey L.P. Inc. have agreed to pay $280 million to settle False Claims Act allegations, the Department of Justice announced today. This settlement resolves claims by the United States that the defendants engaged in a scheme to report false and inflated prices for numerous pharmaceutical products, knowing that federal health care programs relied on those reported prices to set payment rates. The actual sales prices for the Dey products were far less than what Dey reported. The United States alleged that Dey reported false prices for the following drugs: Albuterol Sulfate, Albuterol MDI, Cromolyn Sodium and Ipratropium Bromide. The difference between the resulting inflated government payments and the actual price paid by health care providers for a drug is referred to as the "spread." The larger the spread on a drug, the larger the profit for the health care provider or pharmacist who is reimbursed by the government. The ...
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The drug brand named Ufocollyre contains generic salt - Cromolyn Sodium and is manufactured by PROEL Pharmaceuticals.Ufocollyre is mainly associated with symptoms and indications - The International Classification of Diseases (ICD) - A07EB01 - Cromoglicic Acid ...
Cromolyn is another nonprescrip-tion medication for allergic rhinitis. This drug stabilizes mast cells, reducing the release of histamine and other mediators. It is effective for immunologic triggers and non?immune-mediated triggers, such as chemicals, cold air, or exercise.(2,6) Cromolyn is administered topically; the recommended dose is 1 spray in each nostril 3 to 6 times daily at regular intervals. It may take 3 to 7 days to initially see benefit and up to 2 to 4 weeks of continued therapy before maximal benefit is observed.(2) Because ,7% of the drug is absorbed systemically, side effects are rare. The most common include sneezing, nasal stinging, and burning. The usefulness of cromolyn is often limited because of the need for frequent dosing. It may be most beneficial when used as a pro-phylactic treatment before an anticipated allergen exposure or in patients whose medical conditions do not allow the use of other medications, eg, pregnancy.. Nasal Wetting Agents ...
The first step in treating VKC, as well as all other allergic conditions of the eye, is to identify the allergen. Once the allergen is identified, the patient can then learn to eliminate or avoid the antigen. The aid of an allergist may be very helpful in this regard. Topical therapy may include brief courses of steroids (up to several weeks) to quiet the disease, followed by rapid tapering. Mast cell stabilizers including cromolyn and lodoxamide should be started while the patient is receiving steroids for acute flares since these agents require time for their clinical effects to occur. Once the acute situation is controlled some patients are able to be successfully treated with mast cell stabilizers alone. Other drugs that are being tried include cyclosporine and levocabastine. As was noted above, VKC often spontaneously remits after the late teens ...
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Deaths from asthma greatly increased in Britain between 1961 and 1967. Over the same period the use of pressurised aerosols containing β-stimulants (usually isoprenaline) also increased greatly and it was suggested that the use of such aerosols contributed to the increase in mortality.1 2 Then in 1967 the Committee on Safety of Drugs issued a warning notice and in 1968 the supply of aerosols, previously available over the counter, was restricted to prescription only. From 1967 the death rate fell rapidly, although the use of β-stimulant aerosols showed only a modest decrease.3 This decline in mortality began to occur before the widespread use of bronchodilator aerosols such as isoetharine, salbutamol and terbutaline, which are relatively selective for the β-adrenoceptors of the lungs, before the development of aerosols of locally active corticosteroids, and before disodium cromoglycate was widely used. Moreover in younger patients mortality is still a little higher than it was before the ...
If you have allergies or asthma, your healthcare provider may recommend a drug called cromolyn. This eMedTV selection provides an overview of the drug and includes a link to more detailed information. Cromaline is a common misspelling of cromolyn.
Provides information on usage, precautions, side effects and brand names when available. Data provided by various government agencies and health-related organizations. ...
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Based on the various predicted data for the target chemical and experimental data for structurally and functionally similar read across chemicals study have been reviewed to determine the toxic nature of target chemical disodium [μ-[[7,7-iminobis[4-hydroxy-3-[[2-hydroxy-5-sulphamoylphenyl]azo] naphthalene-2-sulphonato]](6-)]]dicuprate(2-) (6798-03-4) on the growth of aquatic algae and cyanobacteria. The studies are as mentioned below: In the first prediction for the target chemical disodium [μ-[[7,7-iminobis[4-hydroxy-3-[[2-hydroxy-5-sulphamoylphenyl]azo] naphthalene-2-sulphonato]](6-)]]dicuprate(2-) (6798-03-4) using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the eight closest read across substances, toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for disodium [μ-[[7,7-iminobis[4-hydroxy-3-[[2-hydroxy-5-sulphamoylphenyl]azo] ...
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