Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
Gastric antral vascular ectasia (GAVE) is a rare, but serious, cause of upper gastrointestinal bleeding (4% of all gastric hemorrhages). The endoscopic findings are characteristic: linear images, oriented radially and converging on the pylorus (watermelon stomach1,4).. This condition is associated with underlying chronic diseases, mostly with liver cirrhosis. In autoimmune diseases, it is related to the presence of Raynauds phenomenon, and is the form most widely reported of the limited subtype of scleroderma (calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia [CREST syndrome]).5,6 The largest series of patients with GAVE includes 45 individuals, 62% of whom also had a connective tissue disease, predominantly with Raynauds phenomenon (31%) and sclerodactyly (20%).7. The etiology and pathogenesis of GAVE are unknown; one hypothesis is that the histological changes, especially in the lamina propria, are due to a fibromuscular proliferation, vascular ...
We report a case of 62-year-old Tunisian woman with a 10-year history of a CREST syndrome (systemic sclerosis meeting the criteria of the CREST syndrome of the 1980 American College of Rheumatology classification for raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia). Her daughter is treated in neurology for myasthenia gravis. Our patient presents a 5-month history of increasing inflammatory right thumb pain concomitant with the discovery of a subcutaneous hard mass (A). Radiographs of her thumb showed a sub-cutaneous calcification (as another part of the CREST syndrome criteria) (B). X-rays of hands found an acro-osteolysis (C). In the CREST syndrome, the calcific deposits can be subclinical. But, when symptomatic, it becomes painful, tender and an inflammatory reaction can occur facing the calcinosis.
CREST syndrome, also known as the limited cutaneous form of systemic sclerosis (lcSSc) is a multisystem connective tissue disorder. The acronym CREST refers to the five main features: calcinosis, Raynauds phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. It is associated with detectable antibodies against centromeres (a component of the cell nucleus), and usually spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary arterial hypertension. CREST causes thickening and tightening of the skin with deposition of calcific nodules (calcinosis). Raynauds phenomenon is frequently the first manifestation of CREST/lcSSc, preceding other symptoms by years. Stress and cold temperature induce an exaggerated vasoconstriction of the small arteries, arterioles, and thermoregulatory vessels of the skin of the digits. Clinically this manifests as a white-blue-red transitions in skin ...
Crest syndrome is an acronym for Calcinosis; Reynaudssyndrome; Esophagealdysmotility; Sclerodactyly and Telangiectasia. It is also known as Limited
The paper outlines the experience with minimally invasive surgical technologies for esophageal injury in the presence of systemic connective tissue disease. The clinical example clearly demonstrates the importance of timely diagnosis of esophageal stricture in CREST syndrome and suggests that it is necessary to treat these difficult-to-treat patients at large multiprofile hospitals ...
CREST syndrome is related to antibodies that combat centromeres (regions of DNA chromosomes) like ones in the kidneys and lungs. Characterized as an
Tips to help with your thrombocytopenia: Crest Syndrome Thrombocytopenia. My thrombocytopenia, Online resources for thrombocytopenia.
The answer to yesterdays mystery is … limited scleroderma (a.k.a. CREST syndrome)! Great job Priscilla, Kmu, American Girl Mommy, Erin, Rich S, guest, OB1, Phung, Shelly Langlois, mabel, vor120806, Kimberly Helton, CB, Kelly, ColorMaven, Jerry Skrocki, Amanda, Michelle, Tina M., Angelita, ER SEC, Mary, todd dombrowski, JP3, kim labounty, Dazed & Confused, JB, and PJ.. Ill give partial credit to those who named one component of CREST syndrome, Raynauds phenomenon: D2, Patti Ann, Carol, MG, Gracie287, GetAClue, Zach A., Tara Naz, Robert Jones, the other Naomi, Shannon Vincent, Martha, sallad, Michele Liguori, Veronica, Deborah Cote, JP, and GG.. CREST syndrome, or limited cutaneous systemic scleroderma, is an autoimmune disease that causes scarring of different tissues in the body, most notably the skin. The cause of the disease is unknown, but it is likely some combination of genetic factors and environmental triggers. First, inflammatory white blood cells infiltrate the skin and ...
The symptoms involved in CREST syndrome are associated with the generalized form of the disease Systemic sclerosis, scleroderma. CREST is an acronym for the clinical features that are seen in a patient with this disease. The C stands for calcinosis, where calcium deposits form under the skin on the fingers or other areas of the body. The R stands for Raynauds phenomenon, spasm of blood vessels in the fingers or toes in response to cold or stress. The E represents esophageal dysmotility, which can cause difficulty in swallowing. The S is for sclerodactyly, tightening of the skin causing the fingers to bend. Finally, the letter T is for telangiectasia, dilated vessels on the skin of the fingers, face, or inside of the mouth. Usually only 2 of the 5 symptoms of the CREST syndrome is necessary to be diagnosed with the disease. ...
CREST syndrome A less severe form of scleroderma is called CREST.. The CREST syndrome represents symptoms including calcium skin deposits; Raynauds phenomenon (a condition in which the blood vessels of the fingers and toes go into spasm when triggered by factors such as cold, stress, or illness; the result is cold, painful, or numb fingers and toes which in severe cases may become gangrenous); esophageal dysfunction (problems with the esophagus, the tube between the mouth and the stomach); sclerodactyly (skin damage on fingers); and telangiectasia (spider veins), limits skin damage to the fingers.. However, this disease, when coupled with pulmonary hypertension (elevated blood pressures within the lungs), can lead to heart and respiratory failure.. ...
Without Raynauds you cannot diagnose Scleroderma. I think it is completely unprofessional for your doctor to say you have this, or even suspect it - since hes not a rheumatologist. If you dont have Raynauds you dont have this... Something like 98% of those with Scleroderma have very severe Raynauds. Multiple people on this board have Raynauds, but were talking severe Raynauds where your fingers turn mutliple colors and you literally have to put them under warm water to get them back to normal ...
Morphology. Virtually all organs are involved.. 1. Skin. Bundles of the collagen bind the skin to the underlying tissue.. Changes take place in three stages.. Stage I: There is edema which is non-pitting and microscopically there is edema, perivascular lymphocytic infiltrate, capillaries and small arteries are thickened, and there is collagen deposition.. Stage II: Due to an increase in collagen formation, wrinkles disappear. The epidermis becomes thin.. Stage III: This is the atrophic stage where claw-like hand, the face is drawn and mask. Microscopically there is atrophy of the epidermis and increase collagen. Calcification may be seen.. In the late stages due to loss of blood supply ulceration may take place.. Skin involvement may be a part of CREST syndrome. Where:. C = Calcinosis.. R = Raynauds phenomenon.. E = Esophageal involvement.. S = sclerodactyly (localized sclerosis of the finger).. T = Telangiectasia.. 2. Gastrointestinal. Gastrointestinal involvement is seen ,50% of the cases. ...
Main page of ISN Scleroderma Symptom Photo Repository. Pictures include images of amputations, calcinosis, hand contractures, CREST syndrome, gangrene, Raynauds, sclerodactyly, and telangeiectasia.
In this video from Scleroforums, learn more about Scleroderma and Sclerodactyly from Amanda Thorpe for the nonprofit International Scleroderma Network.
The Raynauds phenomenon is named after the French doctor who first wrote about in the 1850. There is Raynauds phenomenon or simply Raynauds is a disorder to the characterized by decreased blood flow usually to the fingers and less frequently to the ears, toes, nipples, knees, or nose. The Raynauds can occur alone or may occur with other diseases. The diseases most frequently by the associated with Raynauds are autoimmune or connective tissue diseases, among others, such as the followings are systemic lupus erythematous and scleroderma and CREST syndrome, Buergers disease, polymyositis, Sjogrens syndrome, occlusive vascular disease, rheumatoid arthritis, cryoglobulinemia. They are one theory links blood disorders to the characterized by increased platelets or red blood cells that may increase the blood thickness. The phenomenon of heart disease will be varying from one person to another person in the real world.. Risk Factor:. The risk of factor is anything that may be increases a persons ...
By: Connie ODonnell How Scleroderma and Paraplegia can have a bright spot in the lives of one couple.. I was not diagnosed with Scleroderma Crest Syndrome until I was into my 50s, but suffered from Raynauds and painful finger ulcers for many years. There isnt a photo of me that I am not sporting bandaids on my fingers. Finally these drove me to a doctor, then a wound care facility. I suffered through much painful debriding until finally I had to have my index fingers amputated. I am an artist and initially this procedure was devastating. However, over the years, my fingers have stiffened and become bent, but I have managed to adapt. I am now almost 65 and still draw and paint, and can diaper a grand child with some difficulty. Six years ago my husband suffered a spinal cord injury and is paralyzed just below his arms. We consider ourselves lucky. He is the hands and I am the legs in our relationship, so together we are a whole.....or somewhat close to one.. ...
Scleroderma is a group of autoimmune diseases that may result in changes to the skin, blood vessels, muscles, and internal organs.[2][6][8] The disease can be either localized to the skin or involve other organs, as well.[2] Symptoms may include areas of thickened skin, stiffness, feeling tired, and poor blood flow to the fingers or toes with cold exposure.[1] One form of the condition, known as CREST syndrome, classically results in calcium deposits, Raynauds syndrome, esophageal problems, thickening of the skin of the fingers and toes, and areas of small, dilated blood vessels.[1] The cause is unknown, but it may be due to an abnormal immune response.[2] Risk factors include family history, certain genetic factors, and exposure to silica.[3][4][5] The underlying mechanism involves the abnormal growth of connective tissue, which is believed to be the result of the immune system attacking healthy tissues.[6] Diagnosis is based on symptoms, supported by a skin biopsy or blood tests.[6] While no ...
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Learn all about sclerodactyly, a condition that can cause the hands to take on a claw shape. This article looks at the symptoms, causes, and treatment.
Gene Information Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation targeting and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al. 2001 [PubMed 11495908]).[supplied by OMIM Mar 2008]. ...
With local nerve compression, calcinosis cutis may cause neuropathic pain, and the presence of adjacent nerves should be a consideration in any excision of a deposition. Valenzuela, A, Chung L., Calcinosis. pathophysiology and management. Curr Opin Rheumatol. vol. 27. 2015 Nov. pp. 542-8. (The authors present an overview of recent studies regarding the epidemiology, pathophysiology, diagnosis, and treatment of calcinosis cutis in patients with systemic sclerosis.) Dima, A, Balanescu, P, Baicus, C. Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases. Rom J Intern Med. vol. 52. 2014. pp. 55-67. (A review of pharmacological treatment options for calcinosis in patients with ACTD.) Del Barrio-Díaz, P, Moll-Manzur, C, Álvarez-Veliz, S, Vera-Kellet, C. Topical sodium metabisulfite for the treatment of calcinosis cutis: A promising new therapy. Br J Dermatol. 2016 Jan 22. (Case series of four patients with calcinosis cutis, secondary to dermatomyositis, ...
Raynaud phenomenon is known to occur in around 10% of the healthy female population and in around 5% of men. In the vast majority of cases, the blood vessels show no evidence of damage. In this case - so called Primary Raynaud phenomenon - the issue appears to be exaggerated spasm of healthy blood vessels.. Raynaud phenomenon is also the most common first symptom of scleroderma and is an important feature in other rheumatologic illnesses such as lupus. In this situation, the blood vessels are damaged and the opening for blood flow is much reduced. Raynaud episodes in scleroderma may reflect normal blood vessel constriction in response to cold superimposed on the narrow plumbing.. Blood flow to the fingers in normal health is around 40 times as much as is needed for oxygen supply and tissue nutrition. When the body is hot, blood flow increases to the hands so as to dissipate heat. This is much like a dog panting on a hot day. Conversely, when the body is cold, it is normal to reduce blood flow to ...
The symptoms of Raynauds phenomenon, arthralgia, and dysphagia point toward the diagnosis of scleroderma. Scleroderma, or systemic sclerosis, is characterized by a systemic vasculopathy of small and medium-sized vessels, excessive collagen deposition in tissues, and an abnormal immune system. It is an uncommon multisystem disease affecting women more often than men. There are two variants of scleroderma ;a relatively benign type called the CREST syndrome C-calcinosis.R- raynaud phen. E- esophagal dysmotility.S-sclerodactyly.T-talangiectasia and a more severe, diffuse disease ...
CALCINOSIS CUTIS TREATMENT PDF - BACKGROUND: Dystrophic calcinosis cutis is a common manifestation in connective tissue diseases, but theres still no consensus on treatment. OBJECTIVES.
Calcinosis cutis is a descriptive term for the deposition of insoluble calcium salts in the cutaneous and subcutaneous tissue. Based upon the etiology of calcium deposition, there are five subtypes of calcinosis cutis: dystrophic, metastatic, idiopat
Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogrens syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE.
The Waardenburg syndromes (WS) are rare genetic disorders described classically as neural crest syndromes and characterized by deafness and pigmentation abnormalities. WS type IV (WS4) is attributed to mutations in the SOX10 gene, which regulates pigment cell development. Here, Kirsten Dutton and colleagues study otic vesicle development using a zebrafish model of WS4, the colourless/sox10 mutant. WS4 patients and mutant fish display a similar spectrum of abnormalities in the ear, pigment cells and enteric neurons. Additionally, the researchers found that only a few neural crest cells contribute to the developing zebrafish ear, and therefore are unlikely to be wholly responsible for the resulting auditory deficits. Their work helps explain the origin of inner ear deficits that lead to hearing loss and vestibular problems in WS4 patients.. Page 68. ...
Raynaud Syndrome Symptom Checker: Possible causes include Raynaud Disease. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Qué es el fenómeno de Raynaud? El fenómeno de Raynaud es una enfermedad que afecta los vasos sanguíneos. Si usted tiene el fenómeno de Raynaud, tiene periodos llamados episodios cuando el cuerpo no envía suficiente sangre a las manos y los pies. Los episodios generalmente ocurren cuando la persona tiene frío o se siente estresada. Durante un episodio, los dedos de las manos y los pies pueden sentirse muy fríos o entumecidos. El fenómeno de Raynaud también se conoce como la enfermedad de Raynaud o el síndrome de Raynaud ...
Qué es el fenómeno de Raynaud? El fenómeno de Raynaud es una enfermedad que afecta los vasos sanguíneos. Si usted tiene el fenómeno de Raynaud, tiene periodos llamados episodios cuando el cuerpo no envía suficiente sangre a las manos y los pies. Los episodios generalmente ocurren cuando la persona tiene frío o se siente estresada. Durante un episodio, los dedos de las manos y los pies pueden sentirse muy fríos o entumecidos. El fenómeno de Raynaud también se conoce como la enfermedad de Raynaud o el síndrome de Raynaud ...
Metastatic calcinosis cutis information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Diagnosis and conservative treatment of raynauds syndrome (Raynaud disease ) (costs for program #151501) ✔ University Hospital Münster ✔ Department of Gerneral Internal Medicine, Nephrology, Hypertension Diseases and Rheumatology (Medical Department D) ✔ BookingHealth.com
Diagnosis of raynauds syndrome (Raynaud disease ) (costs for program #269063) ✔ Klinik Im Park ✔ Department of Vascular Surgery ✔ BookingHealth.com
Definition of Raynaud's disease in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Raynaud's disease? Meaning of Raynaud's disease as a legal term. What does Raynaud's disease mean in law?
Raynaud and Seiver Disease affect the feet, but in different ways. Raynauds Disease causes spasms, while Seivers Disease can mimic Achilles tendonitis.
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
Q: While waiting at the bus stop, my 13-year-old daughters fingers got cold and turned blue, with a clear line between the blue and normal parts. I am going to take her to the pediatrician next week to have her checked, but I wanted to know what this could be.A: The description you give sounds a lot like pediatric Raynaud phenomenon (RP), a transient constriction of the small arteries that can compromise the blood flow to the fingers (less commonly the toes or even the ears), typically
This page includes the following topics and synonyms: Raynauds Phenomenon, Raynauds Syndrome, Raynaud Disease, Raynaud Phenomenon, Raynaud Syndrome.
A 6-month-old boy was referred to our department for the presence of diffuse multiple whitish, pseudomilia-like papules on the skin of the extremities since birth. The patient was well-appearing, and afebrile, with normal vital signs. The examination revealed multiple, yellow-white, firm, small, subcutaneous nodules and papules (Figure 1, A-C). The lesions were present only on the extremities, arms and legs. The lesions were in different stages, with a precise evolution process toward extrusion of a whitish material, erosion and healing (Figure 1, A ...
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Mr. Raynaud, a recent immigrant from France, finds employment as a high school literature teacher in the U.S. One day, a female student bursts into tears in the middle of class. Raynaud walks over
Raynaud's phenomenon, a disorder that affects the blood vessels in the fingers, toes, ears, and nose, can occur as a primary or secondary condition.
Berry, T., Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei D, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE. The ALK(F1174L) Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma. Cancer Cell. 2012 Jul 10;22(1):117-30. ...
Laborator Synevo. Informaţii generale şi recomandari pentru determinarea profilului miozita. Miopatiile inflamatorii idiopatice reprezinta un grup de afectiuni caracterizate prin slabiciunea musculaturii proximale a membrelor, atrofie musculara, semne biochimice şi electromiografice de leziune musculara, anomalii histologice, modificari cutanate caracteristice. Apar cu o incidenta de 0,1-1/100 000 locuitori/an şi sunt mai frecvente la femei. Din acest grup fac parte: polimiozita, dermatomiozita, miozita cu corpi de incluziune, miozita asociată cu neoplazie (sindrom paraneoplazic) şi miozita asociată cu alte boli ale tesutului conjunctiv6;7.. Din punct de vedere histologic miozita poate fi diferenţiata in miozita interstitiala fara distructia fibrei musculare, miozita focala cu infiltrat inflamator si leziuni ale fibrei musculare si miozita difuza.. Polimiozita (PM) se caracterizează clinic prin febra, slabiciune musculara, artralgii, posibil sindrom Raynaud.. In dermatomiozita (DM) ...
Looking for online definition of Raynaud syndrome in the Medical Dictionary? Raynaud syndrome explanation free. What is Raynaud syndrome? Meaning of Raynaud syndrome medical term. What does Raynaud syndrome mean?
Looking for online definition of Raynaud in the Medical Dictionary? Raynaud explanation free. What is Raynaud? Meaning of Raynaud medical term. What does Raynaud mean?
Considering a prevalence of 5-10% in the general population, there is still a place and probably a need for the development of new treatment concepts. Ginkgo biloba has shown to have anti-oxidative and anti-platelet activities. In a small placebo controlled trial in patients with the Raynaud´s phenomenon promising results for the Ginkgo biloba extract were shown. EGb 761® is known to be safe and well tolerated. Based on the above considerations, EGb 761® may be an effective treatment for Raynaud´s phenomenon.. Aim: To determine the efficacy and safety of EGb 761® in patients with Raynaud´s phenomenon on the frequency, duration, and severity of vasospastic attacks compared to placebo. ...
Scleroderma is a disease of the connective tissue featuring prominent skin thickening. Scleroderma can lead to scarring, blood vessel problems, varying degrees of inflammation, and is apparently a manifestation of an overactive immune system. Scleroderma is classified into localized scleroderma and systemic sclerosis. CREST syndrome is a limited form of systemic sclerosis. Patients with scleroderma can have specific antibodies (ANA, anticentromere or antitopoisomerase) in their blood, which strongly suggests an autoimmune etiology ...
CREST Syndrome (Limited Scleroderma) Systemic scleroderma, or systemic sclerosis, is the term for the disease that is characterized by diffuse thickening of the
Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematous (SLE), mixed connective tissue disease, Sjogrens syndrome, scleroderma, polymyositis, CREST syndrome, and neurologic SLE. ...
Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs.. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand.. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma.. Increasing of therapy with phosphate binders and cinacalcet only, was not effective to solve cutaneous masses, that were biopsied. Histological exam revealed deposition of amorphic material with calcific component, consistent with cutaneous dystrophic calcinosis.. We further increased dialysis and therapy and we observed complete regression of masses in 2 months.. Key words: dystrophic ...
Not everyone with scleroderma develops this degree of skin hardening. However, it is this symptom that has earned scleroderma the nickname of the disease that turns people to stone.. Systemic scleroderma often affects the hands. The initial stage is swelling (edema), which can last for weeks, months, or years. Often the swelling is intermittent and worse in the morning. It can cause the fingers to look like sausages, with far fewer wrinkles. Skin tightness in the hands can make it impossible to pinch the skin on the fingers ...
No absolute contraindications exist.. Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM. ...
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This is a photo of a calcium deposit (calcinosis) on a dime. The calcinosis was removed from a patient who has had systemic sclerosis (scleroderma) for a year. ISN Photo Repository.
Generation of a ninein polyclonal antibody. (A) Ninein is a 2096-chain amino acid protein. The 381-689 fragment of ninein (solid bar) was used to generate the n
1. How Can Follow-Up of Patients with Raynaud Phenomenon be Optimized?. Med Sci Monit Basic Res, 2015, 21 p. 47. DOI: 10.12659/MSMBR.893998. Citations as recorded by: ...
Let X be an algebraic curve of genus g⩾2 embedded in its Jacobian variety J. The Manin-Mumford conjecture (proved by Raynaud) asserts that X contains only finitely many points of finite order. When X is defined over a number field, Bogomolov conjectured a refinement of this statement, namely that except for those finitely many points of finite order, the Néron-Tate heights of the algebraic points of X admit a strictly positive lower bound. This conjecture has been proved by Ullmo, and an extension to all subvarieties of Abelian varieties has been proved by Zhang soon after. These proofs use an equidistribution theorem in Arakelov geometry due to Szpiro, Ullmo, and Zhang. Using more classical techniques of diophantine geometry, David and Philippon have given another proof which, moreover, provides an effective lower bound. In the talk, I will present the equidistribution statement, and his powerful generalization due to Yuan. I will then give the proof of the Bogomolov