Cresols can penetrate deeply into tissues that are exposed. After Cresols are absorbed, most of the chemical is metabolized by the liver and either the metabolites or the unchanged chemical are excreted by the kidney with trace amounts excreted via the lungs. In vivo, the Cresol isomers are conjugated and excreted as glucuronides and sulfates. Significant amounts of Cresols are secreted in the bile and undergo enterohepatic recirculation. The kidney is the main route for removing cresols. There are no reports that suggest bio-accumulation of cresol within the living system. ...
CIR Safety Review: The CIR Expert Panel concluded that the toxic effects of cresol and isopropyl cresol ingredients were observed at doses higher than would be available from cosmetics and personal care products. In order to ensure that these ingredients are used at a level that would not cause any adverse effects, the CIR Expert Panel recommended an upper concentration limit. Data were available to demonstrate that m-Cresol and o-Cresol when tested at 0.5% do not cause chemical leukoderma (skin whitening). It may be that Sodium p-Chloro-m-Cresol, p-Chloro-m-Cresol, Chlorothymol, m-Cresol, o-Cresol, Isopropyl Cresols, Thymol, o-Cymen-5-ol and Carvacrol do not cause chemical leukoderma at concentrations higher than 0.5%, but data were not available to support that possibility. Therefore, a concentration limitation of 0.5% was chosen to ensure the absence of a chemical leukoderma effect. p-Cresol was shown to cause depigmentation of hair and possibly the skin. In addition, there was a concern that ...
Read about the chemical and physical properties of 1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (3-trifluoromethyl-phenyl)-amide. Get 1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (3-trifluoromethyl-phenyl)-amide molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
Looking for online definition of 2-Tert-Butyl-4-Methylphenol or what 2-Tert-Butyl-4-Methylphenol stands for? 2-Tert-Butyl-4-Methylphenol is listed in the Worlds largest and most authoritative dictionary database of abbreviations and acronyms
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Genetic evidence that the degradation of para-cresol by Geobacter metallireducens is catalyzed by the periplasmic para-cresol methylhydroxylase: Two pathways fo
3-Amino-4-methylphenol 2836-00-2 NMR spectrum, 3-Amino-4-methylphenol H-NMR spectral analysis, 3-Amino-4-methylphenol C-NMR spectral analysis ect.
151677-97-3 - Acetaldehyde, polymer with 2,5-dimethylphenol, formaldehyde, 3-methylphenol and 4-methylphenol - Searchable synonyms, formulas, resource links, and other chemical information.
Criteria for recommended standard occupational exposure to cresol (93516) have been established and are presented. Criteria and recommendations for cresol apply to the o, m, p, isomers or to any combination of the three isomers in a mixture. In addition, these criteria and recommendations will apply to cresylic-acid (93516) mixtures that contain cresol. Occupational injury from cresol exposure is from skin contact and inhalation. Concentrations of cresol in workplace air on a time weighted average 40 hr week can be no more than 10mg/m3. Procedures for the collection and analysis of environmental samples are given. Methods for medical examination and surveillance of workers including types of clinical tests and the frequency with which they must be administered ar presented. Required labels and warnings and their posting regulations are given. Necessary personal protective equipment include items for eye protection, skin protection and respiratory protection. Regulations for informing employees ...
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2-Cyano-3-(4-methoxy-phenyl)-N-(3-trifluoromethyl-phenyl)-acrylamide | C18H13F3N2O2 | CID 746307 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
A fatality due to the ingestion of solution containing phenol and o-cresol is described. The pathological findings were typical of acute substantial poisoning. Blood, urine and stomach content were obtained during post mortem examinations. Phenol and o-cresol were identified using GC/MS. The extractions from autopsy materials were obtained as follows: by gel permeation with cyclohexane/dichloromethane from stomach content, by solid phase extraction (SPE) from urine and by deproteinization with acetonitrile from blood. The phenol and o-cresol concentrations in the samples were found, respectively, as follows: 115.0 and 5.0 μg/g in the stomach contents, 58.3 and 1.9 μg/ml in the blood, 3.3 and 20.5 μg/ml in the urine. Distributions of phenol in fatal poisonings have been reported [J. Forensic Sci. 27 (1982) 729; Forensic Sci. Int. 19 (1982) 177], but, usually, colorimetry was used as the analytical method and it cannot exclude the interference of other phenolic compounds. ...
Humans excrete between 50 to 100 mg of volatile phenols per day, predominantly in the form of 4-cresol and phenol (mainly as glucuronide and sulfate conjugates) with lower amounts of 4-ethylphenol (20). The production of cresols from tyrosine in mammals has been attributed to various species of Clostridium, Bifidobacterium, and Bacteroides fragilis. Other bacteria such as E. coli are associated with phenol production. Altered levels of 4-cresol metabolites in human urine have been associated with diverse physiological and pathological conditions from weight loss to inflammatory bowel disease. These conditions are also associated with altered microbiota composition, namely a reduction in the diversity of the microbiota because of loss of Lactobacillus and Bacteroides species in the case of inflammatory bowel disease (21) and differences in the ratio of the Firmicutes to Bacteroidetes species in the case of weight loss (22).. Dietary fiber (complex carbohydrates) can be digested and subsequently ...
YAO, Haiyan; REN, Yuan; WEI, Chaohai y YUE, Siyang. Biodegradation characterisation and kinetics of m-cresol by Lysinibacillus cresolivorans. Water SA [online]. 2011, vol.37, n.1, pp.15-20. ISSN 1816-7950.. A novel strain of m-cresol-degrading bacterium, named as Lysinibacillus cresolivorans, was isolated from aerobic sludge from a coking wastewater treatment plant. This bacterium is able to utilise m-cresol as its sole source of carbon and energy. The optimal pH for growth is 6.8 ~ 7.3 and the optimal temperature is 35ºC. Compared to organic nitrogen sources, inorganic nitrogen sources were easily utilised for the m-cresol biodegradation. The degradation rate of m-cresol at different starting concentrations was analysed with zero-order kinetic characteristics. When the initial concentration of m-cresol was 224.2 mg·ℓ-1, the reaction rate reached a maximum at 46.80 mg·(ℓ·h)-1.The cell growth kinetics was also investigated with initial m-cresol concentrations varying from 0 to 1 200 ...
The biocide 4-chloro-3-methylphenol (CMP, CAS number 59-50-7) is a common additive to metal-working fluids (MWF) and building materials. National Institute for Occupational Safety and Health (NIOSH) researchers previously identified and quantified CMP in a commercial water-soluble MWF, TRIM VX, and demonstrated irritancy and sensitization potential of both TRIM VX and CMP alone after dermal exposu
CAS 69-44-3 o-Cresol,4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-,dihydrochloride * Amodiaquin dihydrochloride * Camoquin hydrochloride * 4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol dihydrochloride * Phenol, 4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-, dihydrochloride msds toxicity property
CAS 49649-27-6 o-Cresol, 4-chloro-alpha-(methylimino)- * 5-Chlor-2-hydroxybenzylidenmethylamin * 4-Chloro-alpha-(methylimino)-o-cresol msds toxicity property
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Sigma-Aldrich offers abstracts and full-text articles by [A Torremans, R DHooge, G Van de Vijver, B Marescau, R Vanholder, N Lameire, P P De Deyn, P P Van Bogaert].
Tolerance to p-cresol. Strains R20291 and 630 were tested for their in-vitro tolerance to 0.1% p-cresol. * indicates a significant difference p | 0.01 Studen
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The invention provides a process for preparing a .beta.-lactam derivative represented by the formula ##STR1## the process comprising reacting a .beta.-lactam derivative represented by the following formula (II) and having a protected carboxyl group with a cresol; ##STR2## wherein R represents a benzyl group having an electron-donating group as a substituent on the phenyl ring, a diphenylmethyl group which may have an electron-donating group as a substituent on the phenyl ring or a tert-butyl group.
Transverse intensity patterns imaged at the input or output surfaces, demonstrating the giant and isotropic self-defocusing effect in the m-cresol/nylon solution. (a) The focused Gaussian beam (12μm FWHM) at the input of the sample. (b) The output (33μm FWHM) due to normal diffraction after propagating 2mm in our sample at a power less than 1mW. (c) The output (219μm FWHM) due to strong defocusing nonlinearity at a power of 30mW. (d) The input dark cross (38 μm stripe width) created by using an amplitude mask of two thin wires. (e) Linear diffraction output after 5mm propagation in the sample at a power less than 1mW. (f) At a power of 100mW, the output profile shows that Y-junctions of diverging solitons are created with little variation between the horizontal and vertical directions ...
2,6-Bis(hydroxymethyl)-p-cresol 91-04-3 NMR spectrum, 2,6-Bis(hydroxymethyl)-p-cresol H-NMR spectral analysis, 2,6-Bis(hydroxymethyl)-p-cresol C-NMR spectral analysis ect.
Absorption: In a study with 14C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, at least 77% of the radiolabeled dose was absorbed. Cmax and area under the concentration-time curve (AUC) determined after dosage of tolterodine immediate release are dose-proportional over the range of 1 to 4 mg. Based on the sum of unbound serum concentrations of tolterodine and 5-HMT ("active moiety"), the AUC of tolterodine extended release 4 mg daily is equivalent to tolterodine immediate release 4 mg (2 mg bid). Cmax and Cmin levels of tolterodine extended release are about 75% and 150% of tolterodine immediate release, respectively. Maximum serum concentrations of tolterodine extended release are observed 2 to 6 hours after dose administration.. Effect of Food: There is no effect of food on the pharmacokinetics of tolterodine extended release.. Distribution: Tolterodine is highly bound to plasma proteins, primarily α1-acid glycoprotein. Unbound concentrations of tolterodine average ...
Absorption: In a study with 14C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, at least 77% of the radiolabeled dose was absorbed. Cmax and area under the concentration-time curve (AUC) determined after dosage of tolterodine immediate release are dose-proportional over the range of 1 to 4 mg. Based on the sum of unbound serum concentrations of tolterodine and 5-HMT ("active moiety"), the AUC of tolterodine extended release 4 mg daily is equivalent to tolterodine immediate release 4 mg (2 mg bid). Cmax and Cmin levels of tolterodine extended release are about 75% and 150% of tolterodine immediate release, respectively. Maximum serum concentrations of tolterodine extended release are observed 2 to 6 hours after dose administration. Effect of Food: There is no effect of food on the pharmacokinetics of tolterodine extended release. Distribution: Tolterodine is highly bound to plasma proteins, primarily α1-acid glycoprotein. Unbound concentrations of tolterodine average ...
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Cresol is a methyl substituted, hydroxylated aromatic hydrocarbon that occurs in three isomeric forms. Cresols are refined from coal tar or petroleum; they can also be synthesized. Cresols are toxic to both fauna and flora. Poisoning of humans has resulted from inhalation, ingestion, and absorption of cresol through skin and mucous membranes. Cresol affects the central nervous system, the kidneys, liver, lungs, heart, and stomach. Some fatalities and also carcinogenicity have been attributed to cresol. The principal sources of cresol emissions to the atmosphere are the production of cresols and the production of coke. Adsorption onto activated carbon is the best method for controlling the emission of cresol vapors into the atmosphere ...
Cresol is a methyl substituted, hydroxylated aromatic hydrocarbon that occurs in three isomeric forms. Cresols are refined from coal tar or petroleum; they can also be synthesized. Cresols are toxic to both fauna and flora. Poisoning of humans has resulted from inhalation, ingestion, and absorption of cresol through skin and mucous membranes. Cresol affects the central nervous system, the kidneys, liver, lungs, heart, and stomach. Some fatalities and also carcinogenicity have been attributed to cresol. The principal sources of cresol emissions to the atmosphere are the production of cresols and the production of coke. Adsorption onto activated carbon is the best method for controlling the emission of cresol vapors into the atmosphere ...
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Cardiovascular disease, the leading cause of mortality in hemodialysis patients, is not fully explained by traditional risk factors. To help define non-traditional risk factors, we determined the association of predialysis total p-cresol sulfate, indoxyl sulfate, phenylacetylglutamine, and hippurate with cardiac death, sudden cardiac death, and first cardiovascular event in the 1,273 participants of the HEMO Study. The results were adjusted for potential demographic, clinical, and laboratory confounders. The mean age of the patients was 58 years, 63% were Black and 42% were male. Overall, there was no association between the solutes and outcomes. However, in sub-group analyses, among patients with lower serum albumin (under 3.6 g/dl), a twofold higher p-cresol sulfate was significantly associated with a 12% higher risk of cardiac death (hazard ratio 1.12; 95% confidence interval, 0.98-1.27) and 22% higher risk of sudden cardiac death (1.22, 1.06-1.41). Similar trends were also noted with indoxyl ...
Part I: placebo to tolterodine tartrate 4 mg capsule once a day (qd) for 7 days. Part IIa: placebo to tolterodine tartrate 4 mg capsule qd for 7 days. Part IIb: single dose placebo to tolterodine tartrate 4 mg capsule ...
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Nominated Substances: 2-Acetylamino-4-methylphenol, N-Acetyl-m-aminophenol, 5-(4-Aminobenzamido)-2,3-cresotic acid, 2-Amino-4-chloro-5-nitrophenol, 2-Amino-4-chloro-6-nitrophenol, 2-Amino-6-chloro-4-nitrophenol, 2-Amino-4-chlorophenol, 6-Amino-4-chloro-1-phenol-2-sulfonic acid, 5-Amino-o-cresol, 2-Amino-4,6-dichlorophenol, 2-Amino-4,6-dinitrophenol, 4-Amino-4-hydroxy-3-methyl-diphenylamine, 2-Amino-4-methylphenol, 3-Amino-4-methylphenol, 2-Amino-4-(methylsulfonyl)phenol, 2-Amino-3-nitro-4-methylphenol, 2-Amino-5-nitro-4-methylphenol, 4-Amino-2-nitrophenol, 2-Amino-6-nitro-1-phenol-4-sulfonic acid, 6-Amino-4-nitro-1-phenol-2-sulfonic acid, 3-Aminophenol, p-Aminophenol, 2-Amino-1-phenol-4-sulfonic acid, 3-Amino-5-sulfosalicylic acid, 5-Amino-3-sulfosalicylic acid, 2-Amino-3,4,6-trichlorophenol, 4-(3-Carbazoylamino)phenol, 4-Chloro-2-(2,4-dinitroanilino)phenol, 5-Diethylamino-2-nitroso-4-methylphenol, 5-Diethylamino-2-nitrosophenol, 3-Diethylaminophenol, 3-Dimethylamino-4-methylphenol, ...
Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) increased DNA methyltransferase (DNMT)1, 3a, and 3b expression in vitro. (a) Compared with HK2 cells without IS/
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An attempt was made to isolate and identify those organisms associated with cresol metabolism in the industrial waste waters of Kelly Air Force Base. Results of this work are presented in addition to preliminary studies on the metabolism of cresol oxidation by these organisms. (Author)*Industries
Does being in the sun at the beach or playing sports in the sun in the , heat affect insulin ? Ginny who Has to stay out of the sun. ----- Yes, the sun will affect insulin. First there is the heat from the sun which will affect its viability. Then there is the effect of the sunlight on the cresol preservative, not on the insulin crystals. The sunlight tends to turn the cresol a not-lovely shade of brown. I guess Lilly Co. figures no one wants to inject a brown insulin, so they warn us to avoid sunlight on insulin. George ---------------------------------------------------------- for HELP or to subscribe/unsubscribe, contact: [email protected] send a DONATION http://www.Insulin-Pumpers.org/donate.shtml ...