Article Metrics] Temporal changes in serum creatine kinase concentration and degree of | NDT
Temporal changes in serum creatine kinase concentration and degree of muscle rigidity in 24 patients with neuroleptic malignant syndrome Koichi Nisijima, Katutoshi ShiodaDepartment of Psychiatry, Jichi Medical University, Tochigi, JapanAbstract: Neuroleptic malignant syndrome (NMS) is a dangerous adverse response to antipsychotic drugs. It is characterized by the four major clinical symptoms of hyperthermia, severe muscle rigidity, autonomic dysfunction, and altered mental state. Serum creatine kinase (CK) elevation occurs in over 90% of NMS cases. In the present study, the detailed temporal changes in serum CK and degree of muscle rigidity, and the relationship between CK concentration and degree of muscle rigidity over the time course from fever onset, were evaluated in 24 affected patients. The results showed that serum CK peaked on day 2 after onset of fever and returned to within normal limits at day 12. Mild muscle rigidity was observed before the onset of fever in 17 of 24 cases (71%). Muscle
Conformationally Restricted Creatine Analogs and Substrate Specificity of Rabbit Muscle Creatine Kinase<...
TY - JOUR. T1 - Conformationally Restricted Creatine Analogs and Substrate Specificity of Rabbit Muscle Creatine Kinase. AU - Dietrich, Robert F.. AU - Miller, Robert B.. AU - Kenyon, George L.. AU - Leyh, Thomas S.. AU - Reed, George H.. PY - 1980/1/1. Y1 - 1980/1/1. N2 - Several conformationally restricted analogues of creatine have been both synthesized and examined as potential substrates or inhibitors of rabbit muscle creatine kinase (EC 2.7.3.2). When an asymmetric center was included in a creatine analogue in the position α to the carboxyl group, the enzyme had a pronounced preference for the R enantiomer. Thus, whereas (R)-N-amidinoazetidine-2-carboxylic acid (7) has been shown to be a good substrate (Ks = 72 mM, Km = 39 mM, and Vmax = 29% relative to that of creatine) for creatine kinase, the corresponding S enantiomer 6 showed only barely detectable reactivity (Fmax(rel) ≪ 1%). When the corresponding ring-opened analogue, N-methyl-N-amidino-alanine, was examined as a substrate, ...
Mitochondrial creatine kinase is critically necessary for normal myocardial high-energy phosphate metabolism. - Radcliffe...
The individual functional significance of the various creatine kinase (CK) isoenzymes for myocardial energy homeostasis is poorly understood. Whereas transgenic hearts lacking the M subunit of CK (M-CK) show unaltered cardiac energetics and left ventricular (LV) performance, deletion of M-CK in combination with loss of sarcomeric mitochondrial CK (ScCKmit) leads to significant alterations in myocardial high-energy phosphate metabolites. To address the question as to whether this alteration is due to a decrease in total CK activity below a critical threshold or due to the specific loss of ScCKmit, we studied isolated perfused hearts with selective loss of ScCKmit (ScCKmit(-/-), remaining total CK activity approximately 70%) using (31)P NMR spectroscopy at two different workloads. LV performance in ScCKmit(-/-) hearts (n = 11) was similar compared with wild-type hearts (n = 9). Phosphocreatine/ATP, however, was significantly reduced in ScCKmit(-/-) compared with wild-type hearts (1.02 +/- 0.05 vs. 1.54 +/
Serum creatine kinase and alkaline phosphatase in experimental small bowel infarction<...
TY - JOUR. T1 - Serum creatine kinase and alkaline phosphatase in experimental small bowel infarction. AU - Graeber, Geoffrey M.. AU - Wolf, Robert E.. AU - Harmon, John W.. PY - 1984/7. Y1 - 1984/7. N2 - Serum creatine phosphokinase (CK) and alkaline phosphatase (ALP) rise after mesenteric infarction; it is not known which one rises earlier or which one has the greater elevation. This experiment compared and contrasted the elevations in both these enzyme systems after acute small bowel infarction. Isoenzymes of both systems were analyzed to determine if any qualitative changes occurred. After baseline blood samples had been drawn, 10 dogs had midline laparotomies under general anesthesia. Each was assigned to one of two groups according to a randomized block design. Controls (CON) were closed after exploration (N = 5). The infarction (INF) group had ligation and division of the arteries to the jejunum and ileum (N = 5). Blood samples were obtained from both groups at 3, 6, 9, 12, 24, and 27 hr ...
Creatine supplementation with specific view to exercise/sports performance: an update | Journal of the International Society of...
Creatine is one of the most popular and widely researched natural supplements. The majority of studies have focused on the effects of creatine monohydrate on performance and health; however, many other forms of creatine exist and are commercially available in the sports nutrition/supplement market. Regardless of the form, supplementation with creatine has regularly shown to increase strength, fat free mass, and muscle morphology with concurrent heavy resistance training more than resistance training alone. Creatine may be of benefit in other modes of exercise such as high-intensity sprints or endurance training. However, it appears that the effects of creatine diminish as the length of time spent exercising increases. Even though not all individuals respond similarly to creatine supplementation, it is generally accepted that its supplementation increases creatine storage and promotes a faster regeneration of adenosine triphosphate between high intensity exercises. These improved outcomes will increase
RPC030Mu01 | Recombinant Creatine Kinase B (CK-BB) | Mus musculus (Mouse) USCN(Wuhan USCN Business Co., Ltd. )
RPC030Mu01, Recombinant Creatine Kinase B (CK-BB), CKB; CKBB; CK-B; CK-1; Creatine Kinase, Brain | Products for research use only!
Purification and characteriization of the heterogeneous brain-type creatine kinase in chicken, study of the functional aspects...
Purification and characteriization of the heterogeneous brain-type creatine kinase in chicken, study of the functional aspects of this heterogeneity in different ...
Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium<...
TY - JOUR. T1 - Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. AU - Smith, Craig S.. AU - Bottomley, Paul A.. AU - Schulman, Steven P.. AU - Gerstenblith, Gary. AU - Weiss, Robert G.. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2006/9. Y1 - 2006/9. N2 - BACKGROUND - The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. METHODS AND RESULTS - We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (ATP) synthesis through CK, the primary energy reserve of the heart, to test the hypothesis that ATP flux through CK is impaired in patients with LVH and CHF. Myocardial ATP levels were normal, but creatine phosphate levels were 35% lower in LVH patients (n=10) than in normal subjects (n=14, P,0.006). Left ventricular mass and CK metabolite levels in LVH were not different ...
CREATINE KINASE RESEARCH: Creatine Kinase-Mediated ATP Supply Fuels Actin-Based Events in Phagocytosis
Phagocytosis requires locally coordinated cytoskeletal rearrangements driven by actin polymerization and myosin motor activity. How this actomyosin dynamics is dependent upon systems that provide access to ATP at phagosome microdomains has not been determined. We analyzed the role of brain-type creatine kinase (CK-B), an enzyme involved in high-energy phosphoryl transfer. We demonstrate that endogenous creatine kinase (CK-B), in macrophages is mobilized from the cytosolic pool and coaccumulates with F-actin at nascent phagosomes. Live cell imaging with XFP-tagged CK-B and β-actin revealed the transient and specific nature of this partitioning process. Overexpression of a catalytic dead CK-B or CK-specific cyclocreatine inhibition caused a significant reduction of actin accumulation in the phagocytic cup area, and reduced complement receptor-mediated, but not Fc-γR-mediated, ingestion capacity of macrophages. Finally, we found that inhibition of CK-B affected phagocytosis already at the stage ...
RYR1-related central core myopathy in a Chinese adolescent boy | HKMJ
Central core myopathy is a rare, inherited neuromuscular disorder with a wide spectrum of phenotypic presentations. It is also considered an allelic disease of malignant hyperthermia. We report a case of central core myopathy in a Chinese adolescent boy presenting with atypical clinical features and a moderately elevated serum creatine kinase level. The diagnosis was made from the histopathological findings of central cores on muscle biopsy, and confirmed by the molecular genetic testing for the RYR1 gene mutation. This is the first case of central core myopathy confirmed by molecular study in our locality ...
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial...
AIMS: Increasing energy storage capacity by elevating creatine and phosphocreatine (PCr) levels to increase ATP availability is an attractive concept for protecting against ischaemia and heart failure. However, testing this hypothesis has not been possible since oral creatine supplementation is ineffectual at elevating myocardial creatine levels. We therefore used mice overexpressing creatine transporter in the heart (CrT-OE) to test for the first time whether elevated creatine is beneficial in clinically relevant disease models of heart failure and ischaemia/reperfusion (I/R) injury. METHODS AND RESULTS: CrT-OE mice were selected for left ventricular (LV) creatine 20-100% above wild-type values and subjected to acute and chronic coronary artery ligation. Increasing myocardial creatine up to 100% was not detrimental even in ageing CrT-OE. In chronic heart failure, creatine elevation was neither beneficial nor detrimental, with no effect on survival, LV remodelling or dysfunction. However, CrT-OE hearts
Whole Body Vibration Training Lowers Serum Creatine Kinase Levels in Boys with Duchenne Muscular Dystrophy - Literature for the...
Literature. Novotec Medical and Stratec Medizintechnik: Manufacturer of Galileo training devices and therapy systems, Leonardo mechanography systems and pQCT scanners for the analysis of muscle and bone.
The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression [Abstract]
Background: Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the intermembrane space of mitochondria and catalyzes the reversible exchange of high-energy phosphate between adenosine tri-phosphate (ATP) and phosphocreatine. However, little is known about its expression and function in human prostate cancer progression.. Method: We investigated the expression of uMtCK in 148 prostate carcinoma tissues and matched normal tissue by immunohistochemistry. The expression and localization of uMtCK and hexokinase II, a marker of glycolysis, were examined in prostate carcinoma cell lines using western blot and immunofluorescence.. Results: MtCK expression was significantly lower in high Gleason grade carcinoma compared with normal prostate or low grade ...
Evaluation of an immunoradiometric assay specific for the CK-MB isoenzyme for detection of acute myocardial infarction<...
TY - JOUR. T1 - Evaluation of an immunoradiometric assay specific for the CK-MB isoenzyme for detection of acute myocardial infarction. AU - Al-sheikh, Wajih. AU - Heal, Albert V.. AU - Pefkaros, Kyriacos C.. AU - Pina, Ileana L.. AU - Serafini, Aldo N.. AU - Ihmedian, Ismail H.. AU - Ashkar, Fuad S.. PY - 1984/8/1. Y1 - 1984/8/1. N2 - Clinical evaluation of patients symptoms, electrocardiographic changes and increased serum enzyme levels, specifically creatine kinase (CK)-MB by electrophoresis, are established as the primary diagnostic indicators for myocardial infarction (Ml). Two hundred fifteen patients were evaluated in this study. Of these patients, 102 were admitted to the coronary care unit and 113 were admitted to the emergency room and screened for possible Ml. The immunoradiometric assay used in this study was a double antibody sandwich technique, which utilizes antibody to the M and B monomers of the CK isoenzymes. This assay is specific for the CK-MB isoenzyme, which is present ...
Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane | Biochemical...
We have investigated the role of the protein ubiquitous mitochondrial creatine kinase (uMtCK) in the formation and stabilization of inner and outer membrane contact sites. Using liver mitochondria isolated from transgenic mice, which, unlike control animals, express uMtCK in the liver, we found that the enzyme was associated with the mitochondrial membranes and, in addition, was located in membrane-coated matrix inclusions. In mitochondria isolated from uMtCK transgenic mice, the number of contact sites increased 3-fold compared with that observed in control mitochondria. Furthermore, uMtCK-containing mitochondria were more resistant to detergent-induced lysis than wild-type mitochondria. We conclude that octameric uMtCK induces the formation of mitochondrial contact sites, leading to membrane cross-linking and to an increased stability of the mitochondrial membrane architecture.. ...
Risk factors associated with capture-related death in eastern wild turkey hens
Capture-related mortality has been a notable risk in the handling of eastern wild turkey (Meleagris gallopavo silvestris). Our objective was to evaluate how environmental factors influence risk and identify physiological correlates that could be used to identify susceptible birds. During winter (January-March) 1995-97, 130 eastern wild turkey hens were captured in southeastern Oklahoma and radiocollared. Of those, 20 hens died ??? 14 days of capture. Serum creatine kinase activity (CK; P | 0.01), body temperature (P | 0.01), processing time (P = 0.02), and ambient temperature (P | 0.01) showed a positive relationship with mortality that occurred within 14 days of capture. Plasma corticosterone concentration (P = 0.08) and relative humidity (P | 0.01) showed a negative relationship with mortalities that occurred within 14 days post-capture. Stepwise logistic regression selected CK activity, relative humidity, and ambient temperature as the best predictors of mortality within 14 days post-capture. Our
Identification of cardiolipin as the membrane receptor of mitochondrial creatine kinase and determination of the transverse...
Identification of cardiolipin as the membrane receptor of mitochondrial creatine kinase and determination of the transverse distribution of cardiolipin accross the inner mitochondrial ...
Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19<...
TY - JOUR. T1 - Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19. AU - Yamaoka, L. H.. AU - Pericak-Vance, M. A.. AU - Speer, M. C.. AU - Gaskell, P. C.. AU - Stajich, J.. AU - Haynes, C.. AU - Hung, W. Y.. AU - Laberge, C.. AU - Thibault, M. C.. AU - Mathieu, J.. AU - Walker, A. P.. AU - Bartlett, R. J.. AU - Roses, Allen D.. PY - 1990/2. Y1 - 1990/2. N2 - The myotonic dystrophy (DM) gene is localized to the proximal long arm of chromosome 19. There have been reports of tight linkage to a number of chromosome 19 markers, including APOC2 and creatine kinase muscle type (CKMM), but they did not establish orientation of the 2 markers to DM. We screened several large multi-generational DM families for linkage to a series of chromosome 19 markers including CKMM. CKMM is tightly linked to DM in these data with z(θ̂) = 28.41; θ̂ = 0.01. Analysis of cross-over data indicates CKMM is on the same side and closer to DM than APOC2. Thus, CKMM is a useful probe for carrier ...
Kinetics of creatine uptake in the perfused mouse liver: a 31P-n.m.r. study of transgenic mice expressing creatine kinase (CKBB...
Transport of creatine in the mouse liver has been investigated in vivo and in the perfused organ. Experiments were carried out with transgenic mice expressing creatine kinase in the liver (brain isoenzyme CKBB; EC 7.2.3.2.) [Koretsky, Brosnan, Chen, Chen and Van Dyke (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 3112-3116] and in the corresponding control mice. The animals were fed a regular chow with or without the addition of 10% creatine (w/w) for 5 days. The kinetics of creatine uptake was measured in the perfused liver by 31P-n.m.r. spectroscopy and biochemical analysis following infusion of creatine at concentrations ranging over 0-15 mM and at an extracellular pH of either 7.40 or 6.40. The results suggest that creatine is actively transported by a pH-dependent mechanism obeying a saturable Michaelis-Menten type of kinetics (Km = 0.80 +/- 0.18 and 5.12 +/- 2.40 mM; Vmax. = 0.57 +/- 0.04 and 1.72 +/- 0.32 mumol.g of liver-1.min-1 at pH 7.40 and 6.40 respectively). Creatine export was evaluated ...
Complete nucleotide sequence of dog heart creatine kinase mRNA: Conservation of amino acid sequence within and among species<...
TY - JOUR. T1 - Complete nucleotide sequence of dog heart creatine kinase mRNA. T2 - Conservation of amino acid sequence within and among species. AU - Roman, D.. AU - Billadello, J.. AU - Gordon, J.. AU - Grace, A.. AU - Sobel, B.. AU - Strauss, A.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1985. Y1 - 1985. N2 - Creatine kinase (CK; EC 2.7.3.2) plays an important role in energy metabolism in brain and muscle. Expression of CK isoenzymes is regulated during development and is tissue specific. To define the structures of canine CK isoenzymes and to elucidate the mechanism of regulation in their expression, CK cDNA clones from dog myocardium were isolated. Myocardial CK mRNA is predicted to encode a protein of 381 amino acids. The nontranslated regions of the mRNA comprise at least 38 bases at the 5 end and exactly 345 bases before the poly(A) tail. Partial protein sequences of dog muscle (M) CK and brain (B) CK subunits were determined and compared with the derived ...
Admission Creatine Phosphokinase in Acute Poisoning: Is it a Predictive Factor for the Treatment Outcome?
All subjects were checked for relevant laboratory tests such as complete blood count (CBC), blood urea nitrogen (BUN), serum creatinine (Cr), blood sugar (BS), serum sodium (Na+), serum potassium (K+), urinalysis (U/A) and serum creatine phosphokinase (CPK) based on the standard laboratory methods. They all received the standard and supportive therapy30 by the attending clinical toxicologists of the poisoning emergency department. Patients\ data including age, gender, ingested drug/poison, time elapsed from ingestion to emergency department admission, poisoning severity and result of the laboratory tests were collected with a check list. Patients were followed until any of these situations occurred: recovering without complications, recovering with any complication (acute renal failure, aspiration pneumonitis) and death. The outcome was recorded and then grouped in two major categories: survival without complications group and complications and/or death group. Since seven patients died and all ...
Creatine Kinase MB/Creatine Kinase Ratio
This test measures the amount of creatine kinase (CK), an enzyme, in your blood. The test can help your healthcare provider find out whether youre having a heart attack.
Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis | Read by...
Doxorubicin (DOX) is a widely used, potent chemotherapeutic agent; however, its clinical application is limited because of its dose-dependent cardiotoxicity. DOXs cardiotoxicity involves increased oxidative/nitrative stress, impaired mitochondrial function in cardiomyocytes/endothelial cells and cell death. Cannabidiol (CBD) is a nonpsychotropic constituent of marijuana, which is well tolerated in humans, with antioxidant, antiinflammatory and recently discovered antitumor properties. We aimed to explore the effects of CBD in a well-established mouse model of DOX-induced cardiomyopathy. DOX-induced cardiomyopathy was characterized by increased myocardial injury (elevated serum creatine kinase and lactate dehydrogenase levels), myocardial oxidative and nitrative stress (decreased total glutathione content and glutathione peroxidase 1 activity, increased lipid peroxidation, 3-nitrotyrosine formation and expression of inducible nitric oxide synthase mRNA), myocardial cell death (apoptotic and ...
MB fraction | definition of MB fraction by Medical dictionary
Looking for online definition of MB fraction in the Medical Dictionary? MB fraction explanation free. What is MB fraction? Meaning of MB fraction medical term. What does MB fraction mean?
Intron Length Variation Observed in the Creatine Kinase and Ribosomal Protein Genes of the Swordfish Xiphias gladius<...
TY - JOUR. T1 - Intron Length Variation Observed in the Creatine Kinase and Ribosomal Protein Genes of the Swordfish Xiphias gladius. AU - Chow, Seinen. AU - Takeyama, Haruko. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1998/6. Y1 - 1998/6. N2 - Introns may accumulate much higher genetic variation than exons. Universal primers were designed from the conservative nucleotide sequences of exons to amplify the flanking intron. Length variations in the S7 ribosomal protein (RP) gene intron 1 and mitochondrial creatine kinase (CK) gene intron 6 of the swordfish Xiphias gladius were found. Single or two banded fragment patterns in each individual were observed by agarose gel electrophoresis. Nucleotide sequence analysis revealed that highly polymorphic fragment patterns observed in the RP gene intron 1 were due to different numbers of a TG repeat (microsatellite). The length of the CK gene intron 6 was dimorphic, in which presence or absence of a 24 bp block was responsible ...
Markers of postmatch fatigue in professional rugby league players<...
TY - JOUR. T1 - Markers of postmatch fatigue in professional rugby league players. AU - McLellan, Christopher P.. AU - Lovell, Dale I.. AU - Gass, Gregory C.. PY - 2011/4. Y1 - 2011/4. N2 - McLellan, CP, Lovell, DI, and Gass, GC. Markers of postmatch fatigue in professional rugby league players. J Strength Cond Res 25(4): 1030-1039, 2011-The aim of the present study was to identify neuromuscular, biochemical, and endocrine markers of fatigue after Rugby League match play. Seventeen elite Rugby League players were monitored for a single match. Peak rate of force development (PRFD), peak power (PP), and peak force (PF) were measured during a countermovement jump (CMJ) on a force plate pre and postmatch play. Saliva and blood samples were collected 24 hours prematch, 30 minutes prematch, 30 minutes postmatch, and then at 24-hour intervals for a period of 120 hours to determine plasma creatine kinase concentration ([CK]) and salivary cortisol concentration ([sCort]). There were significant (p , ...
Creatine Kinase, Not Creatinine Kinase [4]<...
TY - JOUR. T1 - Creatine Kinase, Not Creatinine Kinase [4]. AU - Jefferson, James W.. AU - Aga, Vimal. PY - 2003/12. Y1 - 2003/12. UR - http://www.scopus.com/inward/record.url?scp=0344851931&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0344851931&partnerID=8YFLogxK. M3 - Article. C2 - 14624200. AN - SCOPUS:0344851931. VL - 23. SP - 668. JO - Journal of Clinical Psychopharmacology. JF - Journal of Clinical Psychopharmacology. SN - 0271-0749. IS - 6. ER - ...
Augmentation of Creatine in the Heart. - Radcliffe Department of Medicine
Creatine is a principle component of the creatine kinase (CK) phosphagen system common to all vertebrates. It is found in excitable cells, such as cardiomyocytes, where it plays an important role in the buffering and transport of chemical energy to ensure that supply meets the dynamic demands of the heart. Multiple components of the CK system, including intracellular creatine levels, are reduced in heart failure, while ischaemia and hypoxia represent acute crises of energy provision. Elevation of myocardial creatine levels has therefore been suggested as potentially beneficial, however, achieving this goal is not trivial. This mini-review outlines the evidence in support of creatine elevation and critically examines the pharmacological approaches that are currently available. In particular, dietary creatine-supplementation does not sufficiently elevate creatine levels in the heart due to subsequent down-regulation of the plasma membrane creatine transporter (CrT). Attempts to increase passive diffusion
Creatine Supplementation - Bernizilla
Creatine is often a nitrogenous amine that was learned in 1832 (5). It is actually located mostly in skeletal muscle mass, with ninety five% of your bodys creatine retailers located within skeletal muscle mass (49,seventy eight). The full level of creatine in your body is equal towards the no cost creatine in addition the phosphocreatine (11), which equals about one hundred twenty g within a 70-kg man or woman (74). The exogenous sources of creatine are animal merchandise like beef and fish. The conventional dietary consumption of creatine within an omnivorous eating plan is close to one g each day (forty nine,seventy eight). The liver, kidney, and pancreas variety endogenous retailers of creatine (forty nine,78). The endogenous creation of creatine is down-controlled all through exogenous creatine supplementation; having said that the endogenous manufacturing returns to baseline just after supplementation is discontinued (14).The first step in endogenous synthesis of creatine occurs during the ...
micronized creatine vs monohydrate
This means that you can take a much smaller dose of creatine HCL to get similar results as creatine monohydrate. The Kre Alkalyn effectively becomes more efficient than Creatine Monohydrate with 1.5 grams of Kre Alkalyn being equivalent to around 10 to 15 grams of ordinary creatine supplements. Wie häufig wird der Creatine monohydrate vs creatine aller Voraussicht nach benutzt werden? It is much more soluble and absorbent, and absorbs 99% as opposed to the 1% of monohydrate! Also, it appears that when one supplements with creatine, the ability for the muscle to hold glycogen is enhanced. It is still the most wide sold creatine product out of all the rest. Creatine (/ ˈ k r iː ə t iː n / or / ˈ k r iː ə t ɪ n /) is an organic compound with the nominal formula (H 2 N)(HN)CN(CH 3)CH 2 CO 2 H. This species exists in various modifications in solution.Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate (ATP), the energy currency of the cell, primarily in ...
creatine hydrochloride hcl
Mar 30, 2012· As its name suggests, creatine HCL is made by attaching a hydrochloride group to creatine, thereby creating a salt. In attaching this hydrochloride group, the solubility of the molecule increases greatly compared to creatine monohydrate (the existing basic form of creatine). This results in some improved qualities over the already great creatine monohydrate. Benefits of Creatine HCL Creatine Monohydrate vs Creatine HCL. Creatine HCL is the most soluble form of creatine ...
Incremental Value of the Leukocyte Differential and the Rapid Creatine Kinase-MB Isoenzyme for the Early Diagnosis of...
Results:. Of 69 patients with myocardial infarction, only 39% had diagnostic electrocardiographic ST-segment elevation. ST-segment elevation had a specificity of 99% and a positive predictive value of 93%. A relative lymphocytopenia (lymphocyte decrease ,20.3%) or elevated rapid creatine kinase-MB level (,4.7 ng/mL) was more sensitive than ST-segment elevation (sensitivities of 58% and 56%, respectively) but less specific (specificities of 91% and 93%, respectively). The presence of both a relative lymphocytopenia and an elevated rapid creatine kinase-MB level had a sensitivity of 44%, a specificity of 99.7%, and a positive predictive value of 97% (95% CI, 80% to 99%). Both a relative lymphocytopenia and an elevated rapid creatine kinase-MB level were independent (P , 0.001) predictors of infarction in patients without ST-segment elevation. If myocardial infarction was suspected by the presence of both abnormal markers or ST-segment elevation, the sensitivity for early diagnosis increased from ...
China Creatine: Creatine Anhydrous; Creatine Preparation; N-Amidinosarcosine; 5-Chloro-2-Maino Benzotrifluoride; N...
China Creatine: Creatine Anhydrous; Creatine Preparation; N-Amidinosarcosine; 5-Chloro-2-Maino Benzotrifluoride; N-Carbamimidoyl-N-Methylglycine, Find details about China Creatine Anhydrous, Creatine Preparation from Creatine: Creatine Anhydrous; Creatine Preparation; N-Amidinosarcosine; 5-Chloro-2-Maino Benzotrifluoride; N-Carbamimidoyl-N-Methylglycine - Hubei Yuancheng Saichuang Technology Co., Ltd.
Evolution of infarct size during the early use of nifedipine in patients with acute myocardial infarction: the Norwegian...
In a multicenter double-blind study, 227 patients with suspected acute myocardial infarction (AMI) were randomized within 12 hr from onset of symptoms to treatment with nifedipine (112 patients) or placebo (115 patients). AMI was confirmed in 74 patients on nifedipine and in 83 on placebo. Patients with AMI received nifedipine 5.5 +/- 2.9 hr (mean +/- SD) after onset of symptoms. Infarct size was assessed by the release of creatine kinase isoenzyme MB (CK-MB). Infarct size index (CK-MB geq/m2) was 25 +/- 16 (n = 71) in the nifedipine group and 23 +/- 13 (n = 77) in the placebo group (NS). After the first 10 mg of nifedipine systolic blood pressure fell from 147 +/- 30 to 135 +/- 28 mm Hg (p less than .01) and heart rate rose from 75 +/- 18 to 79 +/- 19 beats/min (p less than .01). No change was observed after the first placebo dose. The treatment was continued for 6 weeks. Over this period there were 10 deaths in each group. Early treatment with nifedipine in patients with AMI does not seem to ...
High energy transport gas and method to transport same - DALTON ROBERT C.
A high energy transport gas and a method to transport the high energy transport gas are used to increase the energy content of a pipeline and other vessels that are designed to carry natural gas under
Creatine Monohydrate 1000g - NB | Precise Fitness
What is Creatine Monohydrate?Creatine is a precursor to the bio-energetic fuel creatine phosphate, which replenishes cellular ATP (adenosine triphosphate) levels during maximum intensity contractions. Supplementing with creatine can increase levels of creatine phosphate in the muscle improving work output capacity, power, recovery and muscle hydration. When muscles are hydrated, muscle catabolism (breakdown) is minimized. Creatine Boosts Muscle Strength, Size, and Endurance:Creatine is one of the most researched and important sports supplements today. It has become a must for athletes wanting to increase workout intensity while delaying the onset of fatigue. Research has shown that supplementing with creatine can boost muscle size, strength and endurance, improve athletic performance, and speed muscle recovery. Saturating your muscles with creatine improves your bodys ability to quickly replenish and recycle ATP, which increases muscle energy and delays muscle fatigue. Studies show that when athletes
Creatine: The FAQ - Uristocrat
Not all nutritional supplements are created equal. In fact, most of the stuff being peddled as magical muscle and strength builders are a complete waste of money.. But one supplement has been studied heavily for the past 35 years and consistently been shown to be safe and effective: creatine.. Creatine is in fact one of the most well-researched nutritional supplements on the market. Below are some of the benefits studies have proven come from this supplement:. Creatine can help make you stronger. Several studies have shown that creatine supplementation results in strength gains. In a meta-analysis of 22 studies on creatine, researchers found that individuals who use it show an 8% increase in strength compared to those who dont.. Creatine can help your muscles grow bigger. Creatine makes your muscles look bigger, while actually making them bigger as well. First, creatine causes your muscle cells to store more water which causes your muscles to appear fuller and larger. You may notice the size ...
Creatine Monohydrate - Learn About Creatine - Buy Creatine Supplements - Nutrition Express
Low prices on Creatine! Creatine helps build muscle fast. Creatine (creatine monohydrate) is natural substance and creatine supplementation is an effective way to build muscle and get stronger. In one study, athletes added 19 pounds to their single-rep bench press within just one month of taking creatine. Another study showed an average muscle mass increase of 3.5
Creatine Monohydrate - Learn About Creatine - Buy Creatine Supplements - Nutrition Express
Low prices on Creatine! Creatine helps build muscle fast. Ready to get big? Creatine (creatine monohydrate) is natural substance and creatine supplementation is an effective way to build muscle and get stronger. In one study, athletes added 19 pounds to their single-rep bench press within just one month of taking creatine!
Differential mortality risk of postprocedural creatine kinase-MB elevation following successful versus unsuccessful stent...
Previous studies on the clinical significance of elevated cardiac markers after PCI have produced a spectrum of results (2,3,6,9). Few question the importance of large periprocedural MI, but the inconsistency of data for an association of mortality with lower level CK-MB elevation has nurtured an ongoing debate whether enzyme elevation after otherwise successful PCI actually affects survival.. At least part of the confusion arises from inadequate definition of unsuccessful procedures and thus inability to appropriately adjust outcome data. For example, a recent meta-analysis of seven studies suggested a significant progressive dose-response relationship between CK-MB elevations and subsequent mortality (10). Unfortunately, three of the studies used for this analysis did not adjust for procedure success and two others excluded only patients who died or required emergency bypass surgery. Moreover, one of these studies included patients with abrupt closure or large spontaneous preprocedure MI among ...
Muscletech, Performance Series, CREACTOR, Creatine HCI, Blue Raspberry Blast, 9.31 oz (264 g) - iHerb
Clinically Proven, Max Potency Creatine HCI Formula. Creactor® is a scientifically advanced creatine formula that delivers a powerful micro-dose of creatine. Each serving delivers 750 mg of 100% ultra-pure, laboratory-tested creatine hydrochloride (creatine HCI) plus 750 mg of free-acid creatine - the purest form of creatine, free of acids and salts. This powerful, never-before-seen ratio of creatine molecules delivers an enhanced product. In fact, the amount of creatine in just two micro-sized daily servings of Creactor® is scientifically proven to deliver real results.. Amplified ATP Synthesis. Creactor® rapidly enhances your muscle cells ability to regenerate adenosine triphosphate (ATP), their primary source of anaerobic energy, so you can recover faster between sets.. Enhanced Size, Strength & Recovery. Creactor® will jack up your muscle strength, increase your performance and enhance your muscle size with just two super-concentrated scoops a day.. Zero Fillers or Sugar. Creactor® ...
Universal Nutrition Creatine,
Whats the difference between Universal Creatine Powder and other creatine supplements? The great manufacturing quality and superior form of the Universal Creatine Powder, makes it a global favourite among health conscious bodybuilders. It is methodically prepared from Creatine Monohydrate Powder which is considered the most pure and concentrated form of creatine. Studies have routinely shown an increase in lean body mass with creatine supplementation although this is likely to represent increased water retention in the short-term, activating your muscle tissue fibers to grow bigger in size. Universal Creatine supplement ensures your muscles are well hydrated, giving them a healthy and bulky look.. Buying Guide. You must have heard about Creatine from the guys in gym, but do you know why it is such a big deal? Creatine is a natural substance that is used as an athletic aid for increasing the high intensity athletic performance. You will be amazed to know that since the researchers found out ...
how to use universal creatine
Rest assured, Creatine is 100% natural, produced by the human body, and found in foods like Steak. Having said that, you still should follow all the guidelines on taking it correctly and safely. Universalâ s Creatine Powderâ ¢ provides the purest, most readily absorbed creatine monohydrate available. Two recent studies compared pre versus post-workout creatine ingestion. Creatine will increase your strength and the amount of work your muscles can do, but of course its no magic pill and it should only be a SUPPLEMENT to an already solid base of basics. Which Creatine Supplement Should You Buy? Optimum Nutrition Micronized Creatine Monohydrate Powder took the top spot on our list of the best creatine powders and contains 5g of pure creatine per serving. And you can get 2 for the price of one right now! (see that post for my before and after pics) along with whey protein supplements only. You, as a reader of this website, are totally and completely responsible for your own health and ...
Creatine / Creatine Monohydrate / German Creatine
Creatine is an amino acid produced by the liver and kidneys, and can be derived from a diet that consists of meat and animal products. Unfortunately you would need to eat about ten pounds of meat to have the same amount of creatine, as you would get by taking twenty grams of Creatine monohydrate. In the body, Creatine is changed into a molecule called phosphocreatine, which is an organic compound found in muscle tissue and capable of storing and providing energy for muscular contraction. Also called Creatine phosphate. Phosphocreatine is especially important in tissues such as the voluntary muscles and the nervous system, which periodically require large amounts of energy. Creatine plays an essential role in the energy metabolism of a muscle by helping replace the energy burned during exercise so you can train harder ...
Comparison between cardiac troponin T and creatinine kinase MB mass in the diagnosis of myocardial infarction | Heart
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Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer...
TY - JOUR. T1 - Catalysis of creatine kinase refolding by protein disulfide isomerase involves disulfide cross-link and dimer to tetramer switch. AU - Zhao, Tong Jin. AU - Ou, Wen Bin. AU - Xie, Qiang. AU - Liu, Yang. AU - Yan, Yong Bin. AU - Zhou, Hai Meng. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2005/4/8. Y1 - 2005/4/8. N2 - Protein disulfide isomerase (PDI) functions as an isomerase to catalyze thiol:disulfide exchange, as a chaperone to assist protein folding, and as a subunit of prolyl-4-hydroxylase and microsomal triglyceride transfer protein. At a lower concentration of 0.2 μM, PDI facilitated the aggregation of unfolded rabbit muscle creatine kinase (CK) and exhibited anti-chaperone activity, which was shown to be mainly due to the hydrophobic interactions between PDI and CK and was independent of the cross-linking of disulfide bonds. At concentrations above 1 μM, PDI acted as a protector against aggregation but an inhibitor of reactivation during CK ...
Creatine kinase BB isoenzyme in rugby football players. | Journal of Neurology, Neurosurgery & Psychiatry
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Rhabdomyolysis after performing blood flow restriction training: A case report<...
TY - JOUR. T1 - Rhabdomyolysis after performing blood flow restriction training. T2 - A case report. AU - Tabata, Shogo. AU - Suzuki, Yukio. AU - Azuma, Koichiro. AU - Matsumoto, Hideo. PY - 2016/7/1. Y1 - 2016/7/1. N2 - Rhabdomyolysis is a serious and potentially life-threatening condition related to resistance training. Despite numerous reports of low-intensity blood flow restriction (BFR) training inducing muscle hypertrophy and increasing strength, few reports of rhabdomyolysis related to BFR training have been published. Here, we report a 30-year-old obese Japanese man admitted to our hospital the day after his first BFR training session with complaints of severe muscle pain in his upper and lower extremities, high fever, and pharyngeal pain. He was diagnosed with acute rhabdomyolysis based on a serum creatine phosphokinase level of 56,475 U·L -1 and a urine myoglobin level of ,3,000 ng·ml -1, and with acute tonsillitis based on a white blood cell count of 17,390 and C-reactive protein ...
Fatty-acid-binding protein as a plasma marker for the estimation of myocardial infarct size in humans. | Heart
BACKGROUND--There are substantial amounts of cytoplasmic heart-type fatty-acid-binding protein (FABP) (15 kDa) in myocardial tissue. The rapid release of FABP into plasma during ischaemia indicates the possibility of using this protein as a biochemical marker for ischaemic myocardial injury. OBJECTIVE--To study the completeness of the release of FABP from damaged tissue in patients with acute myocardial infarction (AMI) and the suitability of serial plasma FABP concentrations for estimation of myocardial infarct size. METHODS--Immunochemically assayed FABP and enzymatically assayed creatine kinase isoenzyme MB (CK-MB) and alpha-hydroxybutyrate dehydrogenase (HBDH) were determined serially in plasma samples from 49 patients with AMI who had been treated with thrombolytic agents within six hours after the onset of AMI. Previously validated circulatory models and a value of 2.6 h-1 for the fractional clearance rate of FABP from plasma were used to calculate cumulative protein release into plasma. ...
Browse In Pioglitazone, Female, Greece | EDM Case Reports
Proteinuric renal disease is prevalent in congenital or acquired forms of generalized lipodystrophy. In contrast, an association between familial partial lipodystrophy (FPLD) and renal disease has been documented in very few cases. A 22-year-old female patient presented with impaired glucose tolerance, hyperinsulinemia, hirsutism and oligomenorrhea. On examination, there was partial loss of subcutaneous adipose tissue in the face, upper and lower limbs, bird-like facies with micrognathia and low set ears and mild acanthosis nigricans. Laboratory investigations revealed hyperandrogenism, hyperlipidemia, elevated serum creatine kinase and mild proteinuria. A clinical diagnosis of FPLD of the non-Dunnigan variety was made; genetic testing revealed a heterozygous c.1045C , T mutation in exon 6 of the LMNA gene, predicted to result in an abnormal LMNA protein (p.R349W). Electromyography and muscle biopsy were suggestive of non-specific myopathy. Treatment with metformin and later with pioglitazone ...
Creatine kinase and endocrine responses of elite players pre, during, and post rugby league match play<...
TY - JOUR. T1 - Creatine kinase and endocrine responses of elite players pre, during, and post rugby league match play. AU - McLellan, Christopher P.. AU - Lovell, Dale I.. AU - Gass, Gregory C.. PY - 2010/11. Y1 - 2010/11. N2 - The purpose of the present study was to (a) examine player-movement patterns to determine total distance covered during competitive Rugby League match play using global positioning systems (GPSs) and (b) examine pre, during, and postmatch creatine kinase (CK) and endocrine responses to competitive Rugby League match play. Seventeen elite rugby league players were monitored for a single game. Player movement patterns were recorded using portable GPS units (SPI-Pro, GPSports, Canberra, Australia). Saliva and blood samples were collected 24 hours prematch, 30 minutes prematch, 30 minutes postmatch, and then at 24-hour intervals for a period of 5 days postmatch to determine plasma CK and salivary testosterone, cortisol, and testosterone:cortisol ratio (T:C). The change in ...
Search | The Journal of the American Osteopathic Association
TOPICS: myocardial infarction, acute, myocardial infarction, unstable angina, creatine kinase mb, cardiac markers, cardiac troponin i, traumatic injury of skeletal muscle, cardiac troponin measurement, creatine kinase mb isoenzyme The Journal of the American Osteopathic Association, April 2004, Vol. 104, 165-176. doi: 10.7556/jaoa.2004.104.4.165 ...
Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models
Humans and mice with deficiency of the alpha2 subunit of the basement membrane protein laminin-2/merosin suffer from merosin-deficient congenital muscular dystrophy (MCMD). We have expressed a human laminin alpha2 chain transgene under the regulation of a muscle-specific creatine kinase promoter in …
Creatine Monohydrate - Pros and Cons of Creatine Monohydrate - Side Effects and Dosage Info
What exactly is Creatine?. Creatine (Cr) is a naturally occurring amino acid found in muscle tissue of humans and animals. It plays an important role in fueling muscles. The human body has 100 to 115 grams of creatine stored in the form of creatine phosphate or phosphocreatine. Approximately 95% of the bodys creatine supply are found in the skeletal muscles. The remaining 5% are scattered throughout the rest of the body, with the highest concentrations in the heart, brain and testes. Creatine is easily absorbed from the intestinal tract into the bloodstream. When dietary consumption is inadequate to meet the bodys needs, a limited supply can be synthesized from the amino acids arginine, glycine and methionine. This creatine production occurs in the liver, pancreas and kidneys. There havent been any negative side effects noted in the research with creatine when using the recommended levels of supplementation. But you should be aware that creatine creates a byproduct called creatinine. ...
Nutrients | Free Full-Text | Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men...
Guanidinoacetic acid (GAA) conversion to creatine is thought to be involved in cardiometabolic disturbances through its role in biological methylation and insulin secretion. We evaluated the association of serum GAA and creatine with cardiometabolic risk factors in a cohort of 151 apparently healthy adults (82 women and 69 men) aged 18-63 years. Serum levels of GAA and creatine were measured with liquid chromatography-tandem mass spectrometry. A multiple linear regression model adjusted for age and sex was employed to examine the relationship of serum GAA and creatine with cardiometabolic risk factors. Higher GAA levels were associated with an unfavorable cardiometabolic risk profile (higher insulin, higher total homocysteine, and higher body fat percentage), while having elevated serum creatine levels (≥31.1 µmol/L) was associated with being overweight (body mass index ≥ 25.0 kg/m). The results from our study suggest a possible role of the GAA-creatine axis in the pathogenesis of cardiovascular
Red Yeast Rice, the Real Statin | Topics in Evidence-Based Pharmacy Practice | AccessPharmacy | McGraw-Hill Medical
Red yeast rice (Monascus purpureus), a traditional Chinese medication, has been used for many years to effectively lower cholesterol.1,2 As a natural alternative to treat dyslipidemia, red yeast rice has the same chemical identity as lovastatin.1 Lovastatin along with the other HMG Co-A reductase inhibitors (statins) have been associated with statin-associated myopathy (SAM). This clinical syndrome can occur in 5% to 10% of statin users.2,3 Myopathy may be further categorized as myalgias (muscle pain), myositis (enzyme leak with increased creatine kinase levels), or rhabdomyolysis (creatine kinase elevations >10,000 u/L associated with acute renal failure). There is no consensus on how to treat dyslipidemias in patients who cannot tolerate statin therapy due to SAM. While, red yeast rice has been associated with the development of symptomatic myopathies only in case reports, it is perceived by some to be a real alternative to statin therapy.4 A recent clinical trial evaluated the effectiveness ...
Limb-girdle muscular dystrophy 2Y
An autosomal recessive form of limb-girdle muscular dystrophy, a degenerative myopathy characterized by slowly progressive wasting and weakness of the proximal muscles of arms and legs around the pelvic or shoulder girdles, elevated creatine kinase levels and dystrophic features on muscle biopsy. LGMD2Y is characterized by muscle weakness initially involving the proximal lower limbs, followed by distal upper and lower limb muscle weakness and atrophy. Other features include joint contractures, rigid spine, and restricted pulmonary function. Cardiac involvement has been observed in some patients. Disease onset is in the first or second decades of life ...
Creatines Role in Enhancing Memory & Preventing Alzheimers - Dr. Fitt Info : Dr. Fitt Info
The Cognitive Benefits of Creatine Explained. When you think of creatine, your first thought may be of the stereotypical athletic guy with pumped up muscles doing curls at the gym. The sports supplement industry has entirely focused the discussion on creatines benefits for athletic performance.. However, youll probably be surprised to hear then that its actually been over a decade now since scientists demonstrated that supplementing creatine can significantly enhance cognition and delay mental fatigue.. Since 2003, the evidence for these effects have been dramatically growing every year. As more and more people become aware of facts about how creatine boosts cognition, theres no doubt that soon youll be as likely to find people discussing the supplement in the office, library and college dormitories as much as in the weight room.. This article explains why and how creatine is crucial for high-functioning cognition.. Creatine Supplementation Enhances Brain Power. Creatine is a naturally ...
Longitudinal trends in the severity of acute myocardial infarction: A population study in Olmsted County, Minnesota<...
TY - JOUR. T1 - Longitudinal trends in the severity of acute myocardial infarction. T2 - A population study in Olmsted County, Minnesota. AU - Hellermann, Jens P.. AU - Reeder, Guy S.. AU - Jacobsen, Steven J.. AU - Weston, Susan A.. AU - Killian, Jill M.. AU - Roger, Véronique L.. PY - 2002/8/1. Y1 - 2002/8/1. N2 - The mechanisms of the decline in coronary heart disease mortality are not fully elucidated. In particular, little is known about the trends in severity of myocardial infarction, which may have contributed to the mortality decline. This study examines indicators of myocardial infarction severity including Killip class, electrocardiogram descriptors, and peak creatine kinase values in a population-based, myocardial infarction incidence cohort to test the hypothesis that the severity of myocardial infarction declined over time. Between 1983 and 1994, 1,295 incident cases of myocardial infarction (mean age, 67 (standard deviation, 6) years; 43% women) occurred in Olmsted County, ...
Evaluation of cardiac troponin I (cTnI), electrocardiography, creatine kinase (CK) and aspartate aminotransferase (AST) in...
BACKGROUND: Cardiac Troponin I (cTnI) is known as a cardiac biomarker in determining the myocardial damage of diseases which affect the heart muscle. OBJECTIVES: This study aims to evaluate the serum cTnI concentration in Markhoz Breed goats suffering selenium (Se) deficiency and its correlation with electrocardiographic parameters, and activity of creatine kinase (CK) and aspartate aminotransferase (AST) enzymes, as well as to determine the diagnostic value of troponin in that disease. METHODS: Blood samples of 94 goat kids of Markhoz breed with the age less than one month were taken, serum analyzed for the assessment of cTnI, CK and AST, 2 ml blood was used for determination of selenium concentration. Electrocardiography was recorded from all kids by using base-apex lead. Kids were divided into two groups based on serum selenium concentration. RESULTS: The concentration of cTnI was significantly higher in deficient kids compared with the control group. Results indicated significant negative
Creatine Phosphokinase Increased & Inability to Supinate Forearm & Joint Hypermobility: Causes & Reasons - Symptoma
Creatine Phosphokinase Increased & Inability to Supinate Forearm & Joint Hypermobility Symptom Checker: Possible causes include Myoadenylate Deaminase Deficiency. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Muscle damage and the repeated bout effect in male bodybuilders follow by Kennedy Blowfield
This study investigated muscle damage of bodybuilders who performed an unaccustomed intense resistive exercise bout. Ten male bodybuilders (age: 23 ± 2 y, height: 177.6 ± 6.3 cm, body mass: 85.7 ± 8.1 kg) with a minimum of 4-years resistance training experience performed 17 exercises targeting the pectoral muscles. Eight of the 10 bodybuilders repeated the same exercises two weeks later. Muscle function (bench press throw, maximal isokinetic elbow extension and flexion concentric torque: MVC torque), muscle soreness using a visual analogue scale (VAS: 100-mm), and plasma creatine kinase (CK) activity were assessed before, immediately after and 24, 48 and 72 hours after exercise. Bench press throw peak force decreased immediately (23 ± 20%) and 24 hours after the first exercise bout (9 ± 15%), but, returned to baseline (930 ± 129 N) by 48 hours post-exercise (P|0.05). MVC torque also decreased but, returned to baseline by 48 hours post-exercise. Muscle soreness peaked 24 hours post-exercise (57 ±
Creatine HCL vs. Creatine Monohydrate - Bestpreworkoutforwomen
Both compounds serve as a supplement to the body as there are only slight changes in their structure. More than a thousand researches have been done on Creatine Monohydrate, and there are about very few studies done on the latter. This makes us believe that Creatine Monohydrate is the one we should include in our diets or the pre-workouts. But the data recorded by the consumers have different things to reveal. Consumers find an issue with the Creatine Monohydrate that it is not much soluble in water. Studies have also proved that Creatine Monohydrate dissolves only 3% of the actual intake in the intestinal cells and the tissue fibers that too in more than 90 minutes. It usually causes diarrhea, intestinal contractions, and abdominal pains due to the particles settling down in the intestinal walls. Thus, it requires more water than necessary to make the particles moving, which further increases the blood pressure to an undesirable rate. Comparatively, Creatine HCL being more acidic dissolve ...
Creatine supplements - Wikipedia
Creatine supplements are dietary supplements marketed as increasing high-intensity athletic performance. There is scientific evidence that short term creatine use can increase maximum power and performance in high-intensity anaerobic repetitive work (periods of work and rest) by 5 to 15%. Studies in endurance athletes have been less than promising, most likely because these activities are sustained at a given intensity and thus do not allow for significant intra-exercise synthesis of additional creatine phosphate molecules. Ingesting creatine can increase the level of phosphocreatine in the muscles up to 20%. Creatine has no significant effect on aerobic endurance, though it will increase power during short sessions of high-intensity aerobic exercise. Creatine use is not considered doping and is not banned by the majority of sport-governing bodies. However, in the United States, the NCAA recently ruled that colleges could not provide creatine supplements to their players, though the players are ...
The Effect of Green Tea on Simvastatin Tolerability | Annals of Internal Medicine | American College of Physicians
Case Report: A 61-year-old man had a history of primary hypercholesterolemia identified at age 50 years, and treatment with different statins was unsuccessful because of early muscle intolerance. He reported a family history of premature coronary disease, hypertension, and hypercholesterolemia, but no heritable myopathy. The patient had been treated for hypertension since age 45 years with amlodipine, 10 mg/d. Low-density lipoprotein cholesterol-lowering treatment with simvastatin, atorvastatin, or rosuvastatin (all at 10 mg/d) had been hampered by intense leg muscle cramps and pain with normal creatine phosphokinase levels. Liver enzyme levels also moderately increased within 1 week of statin treatment initiation. These adverse effects compelled the patient to immediately interrupt treatment. The patient was generally healthy and physically active. He had never smoked or consumed alcohol in excess. His physical examination was normal. Ultrasonography showed minimal carotid atheroma. Blood tests ...
high creatine level - Symptoms, Treatments and Resources for high creatine level
Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and...
BACKGROUND: The failing myocardium is characterized by reductions of phosphocreatine (PCr) and free creatine content and by decreases of energy reserve via creatine kinase (CK), ie, CK reaction velocity (Flux(CK)). It has remained unclear whether these changes contribute directly to contractile dysfunction. In the present study, myocardial PCr stores in a heart failure model were further depleted by feeding of the PCr analogue beta-guanidinopropionate (GP). Functional and metabolic consequences were studied. METHODS AND RESULTS: Rats were subjected to sham operation or left coronary artery ligation (MI). Surviving rats were assigned to 4 groups and fed with 0% (n=7, Sham; n=5, MI) or 1% (n=7 Sham+GP, n=8 MI+GP) GP. Two additional groups were fed GP for 2 or 4 weeks before MI. After 8 weeks, hearts were isolated and perfused, and left ventricular pressure-volume curves were obtained. High-energy phosphate metabolism was determined with (31)P NMR spectroscopy. After GP feeding or MI, left ventricular
Abstract 3448: Cardiac Dystrophinopathies: Prevalence and Clinical Phenotypes in a Consecutive Series of 408 Males with...
Dystrophin gene (DYS) defects cause three major clinical phenotypes: Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) and X-linked dilated cardiomyopathy (DCM). In the cardiology setting patients come to the clinical attention for DCM with/without increased serum creatine phosphokinase (sCPK) and/or myopathy. Purpose To determine the prevalence of DYS defects in a consecutive series of 408 DCM patients and to describe their phenotypes.. Methods DCM was diagnosed according to WHO criteria. The criterion for first level DYS screening was male sex: we included males with both normal and increased sCPK. The criterion for second level DYS screening was the presence of defects of myocyte immunostaining by 5′, rod, midrod and C-terminal domain using anti-DYS antibodies at endomyocardial biopsy. This latter analysis consisted of the direct automated sequencing of the 75 exons and flanking regions of the gene.. Results We identified DYS defects in 31 of the 408 probands (7.6%); the ...
ETA receptor blockade protects the small intestine against ischaemia/reperfusion injury in dogs via an enhancement of...
The aim of the present study was to determine whether the ETA receptor antagonist LU135252 can protect the mesenterium against ischaemia/reperfusion (I/R) damage. Direct occlusion of the superior mesenteric artery was performed for 30min in two groups of dogs. Declamping was followed by 90min of reperfusion. Mesenteric release of ET-1 was studied in series 1 (n = 6). In series 2, 5min before cross-clamping, the treated group (n = 7) received an intravenous bolus of LU135252 (5mg/kg), whereas the control group (n = 6) was given vehicle. Mean arterial blood pressure and mesenteric blood flow were recorded. Mesenteric venous and systemic arterial serum lactate and glucose, plasma creatine kinase and free radical concentrations were determined at 15min intervals. Ischaemia for 30min induced a significant increase (P,0.05) in mesenteric ET-1 release (1594±526pg/min, compared with 343±258pg/min at baseline), which had returned to baseline after 20min of reperfusion. LU135252 administration ...
Relationships between match activities and peak power output and Creatine Kinase responses to professional reserve team soccer...
Fingerprint Dive into the research topics of Relationships between match activities and peak power output and Creatine Kinase responses to professional reserve team soccer match-play. Together they form a unique fingerprint. ...
Creatine kinase-catalyzed reaction rate in the cyanide-poisoned mouse brain<...
TY - JOUR. T1 - Creatine kinase-catalyzed reaction rate in the cyanide-poisoned mouse brain. AU - Holtzman, David. AU - Offutt, Martin. AU - Tsuji, Miles. AU - Neuringer, Leo J.. AU - Jacobs, Danny. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 1993. Y1 - 1993. N2 - Brain creatine kinase (CK)-catalyzed phosphorus flux from phosphocreatine (PC) to ATP was measured in vivo in young adult mice made reversibly hypoxic by injection of cyanide. Phosphorus spectra and saturation transfer measurements of CK-catalyzed flux were acquired using a high-field (8.45 T) nuclear magnetic resonance (NMR) spectrometer. After low cyanide doses (1-3 mg/kg of body weight), there were no measurable changes in brain pH or in concentrations of PC, the nucleoside triphosphates (including ATP), and Pi. The CK-catalyzed phosphorus flux increased about 75% after the low cyanide dose. Higher doses (4-6 mg/kg) produced a transient 30-40% decrease in PC concentration, doubling of Pi, and a 0.2 unit ...
Bodybuilding O Corpo Libero B Complex Injection Bodybuilding | 8000 Calories A Day Bodybuilding Bodybuilding O Que
Creatine, which is synthesized in the liver and kidneys, is transported through the blood and taken up by tissues with high energy demands, such as the brain and skeletal muscle, through an active transport system. The concentration of ATP in skeletal muscle is usually 2-5 mM, which would result in a muscle contraction of only a few seconds.[22] During times of increased energy demands, the phosphagen (or ATP/PCr) system rapidly resynthesizes ATP from ADP with the use of phosphocreatine (PCr) through a reversible reaction with the enzyme creatine kinase (CK). In skeletal muscle, PCr concentrations may reach 20-35 mM or more. Additionally, in most muscles, the ATP regeneration capacity of CK is very high and is therefore not a limiting factor. Although the cellular concentrations of ATP are small, changes are difficult to detect because ATP is continuously and efficiently replenished from the large pools of PCr and CK.[22] Creatine has the ability to increase muscle stores of PCr, potentially ...
Order Divalproex online - Safe Divalproex online no RX
A pharmacokinetic study of rosuvastatin conducted in the United States demonstrated an imprecise 2-fold elevation in median exposure in Asian subjects (having either Filipino discount divalproex 500 mg online x medications, Chinese purchase genuine divalproex treatment 5 alpha reductase deficiency, Japanese best 5mg bisoprolol, Korean, Vietnamese, or Asian-Indian origin) compared with a Caucasian control league. Are there differences in the harms Good for Although creatine kinase elevations are customary, the gamble of of statins or fixed-dose syndication statins symptomatic myopathy is deficient. There is no support that noble transaminases Statins Side 80 of 128 Ultimate Relate Update 5 Panacea Effectiveness Review Project Sinew of Explanation question mark Conclusion associated with statin hate lengthen the chance of clinically relevant liver miscarriage. In a trial of 2 doses of atorvastatin, the quantity of untiring elevations in liver aminotransferase levels 2 per 1000 in patients fetching ...
Mcpgoldberg
study: a patient treated with atorvastatin, 20 mg/d, died of Ezetimibe/simvastatin reduced LDL-C levels by more than chronic obstructive pulmonary disease (not considered 50% from baseline at these doses, fulfilling the ADA rec- ommendation of a 30% to 40% reduction from baseline.2 Laboratory adverse events occurred in 8 patients (1.6%) This study also confirmed the superior attainment of LDL- in the ezetimibe/simvastatin group and 10 patients (1.4%) C levels of less than 70 mg/dL in high-risk patients with in the atorvastatin group. Drug-related LAEs occurred in 3 ezetimibe/simvastatin vs atorvastatin and did so across a patients in both treatment assignments. No serious LAEs wider range of dosages than previously reported.20 Thus, occurred, and no patients discontinued study participation these results add to the clinical experience with ezetimibe/ simvastatin, affirming its effectiveness in the management No patient had a creatine kinase elevation 10 or more of high LDL-C levels11-13,20,21 ...
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Doxapram, which produces vesicular lesions on hands, feet, and digits c,, latissimus dorsi, teres major c,long flexors c,, t thumb extensors c, interossei, lumbricales, thenar, hypothenar c, t a a middle-aged woman. Secondary to an allergen to covalently link multiple ige molecules and causes coagulation. Retinal thrombosis may occur in an afebrile child. Meningitis or varicella infections should be assured. What are likely to be in remission in at presentation. In patients presenting with acute pericarditis. For severe attacks involving the gi tract with chronic hyperten-sion. Complications transfusion-transmitted disease hepatitis c virus infection neonatal herpes is of limited value in proximal small bowel obstruction. Creatine kinase elevations may range from awake and alert to the standard infant formulas, specific metabolic disease is associated with a febrile seizure the two diseases bullous varicella. J pediatr . Enuresis diagnosis although few children with alopecia totalis, a wig is ...
教員情報 - 石田 一世
BACKGROUND: Peak creatine kinase-MB (CK-MB) level is associated with clinical outcomes after acute myocardial infarction (AMI). However, the prognostic impact of time between balloon and peak CK-MB (BP-time) after percutaneous coronary intervention (PCI) is unclear. METHODS: This multicentral observational study initially included 1,354 AMI patients undergoing primary PCI within 24 hours after the onset between 2011-2016. After the exclusion of patients with unknown onset time of AMI, patients with the highest CK-MB at baseline, and patients without postPCI TIMI grade 3 flow, 954 patients were ultimately enrolled. They were divided into 4 groups by BP-time with 3-hour increment. The primary endpoint was all-cause mortality. RESULTS: Kaplan-Meier analysis showed that patients with BP-time,3-hours had the lowest, and with BP-time,9-hours had the highest mortality (at 3 years: 5.5% vs. 11.6%, Figure). Multivariate Cox regression analysis revealed that BP-time was an independent predictor of ...
Source Naturals Amino Acids - Source Naturals - Creatine 1000 mg - 100 tabs
Creatine 1,000 mg Tablets
Supports Muscular Activity
Creatine monohydrate is converted to creatine phosphate (CrP) in muscle tissue. CrP provides a critically important store of energy which helps to power short bursts of intense muscular activity, as in sprinting or weightlifting. CrP is used up in regenerating the ATP consumed during intense exercise, and is itself renewed when creatine interacts with ATP during the rest period immediately after strenuous exercise.
Supplement Facts for 1,000 mg Tablet
Serving Size: 5 tablet(s)
Amount Per Serving - % Daily Value
Calories 10
Fat Calories 5
Total Fat 0.5 g less than 2%
Saturated Fat 0.5 g 2%
Total Carbohydrates 1 g less than 2%
Creatine Monohydrate 5 g
Other Ingredients: sorbitol, stearic acid, hydroxypropyl cellulose, modified cellulose gum, and magnesium stearate.
Warning: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
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Sponser Creatine Monohydrate - Rowperfect UK
Creatine increases physical performance in successive bursts of short-term, high intensity exercise (for example sprint, dumbbell workout). Creatine monohydrate contains as only ingredients pure creatine monohydrate and is completely neutral tasting.. Creatine is usually absorbed by the body through eating meat and fish and is then stored in the muscle fibres as creatine phosphate. For an efficient storage and corresponding effects, a several week-long programme taking this supplement is necessary. ...
MuscleTech CellTech Creatine Powder Micronized
In addition to increasing energy, creatine accelerates recovery in your muscles and even increases muscle mass. How does creatine do these things? It allows your body to endure through longer periods of extreme exercise which helps your muscle grow. It also increases cell signaling that helps with muscle growth and more importantly muscle recovery. Finally, creatine elevates water levels in the cells, which not only helps with the function but also plumps the muscle up.. Taking creatine is shown to significantly reduce the breakdown of proteins that comprise our muscles. It encourages the growth of the muscle by lowering myostatin levels, the protein that can prevent muscle growth. Additional studies have found that the increase of phosphocreatine in the brain enhances function and can prevent neurological malfunctions.. Creatine can have other benefits, too, says Dr. Niket Sonpal, a doctor based in New York City.. Sleep deprivation has a negative effect on mental performance and mood. This can ...
Cardiovascular Health & Anti-inflammatory Benefits: Animal | Cranberry Institute
The present study is designed to investigate the role of certain natural cranberry and rosemary extracts to improve the histological changes in the cardiac muscle toxicity of adult male albino rats weighing 110±5g (aged 3-4 weeks) induced by doxorubicin (DOX). To assessment of cardiotoxicity, the cardiac enzyme creatine kinase (CK-MB) and troponin I protein were measured. The animals were divided into 7 equal groups (10 rats /each); Gp. I: normal control rats group injected with saline solution 0.9 % intraperitoneally (i.p.) for three times per a week for three weeks, Gp. II: cranberry rats group administrated orally with 150 mg/kg/bw for three times per a week for three weeks, Gp III rosemary rats group administrated orally with 2g/kg/bw for three times per a week for three weeks, Gp IV: DOX rats group injected i.p. with 2.5mg/kg three times / week for two weeks, Gps: V, VI & VII: DOX rat groups administrated orally with cranberry or rosemary or both together in the same previous doses and ...
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1. Green AL, Hultman E, MacDonald IA, Sewell DA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol. 1996;271:E821-E826. 2. Steenge GR, Lambourne J, Casey A, et al. Stimulatory effect of insulin on creatine accumulation in human skeletal muscle. Am J Physiol. 1998;275:E974-E979. 3. Nelson AG, Arnall DA, Kokkonen J, et al. Muscle glycogen supercompensation is enhanced by prior creatine supplementation. Med Sci Sports Exerc. 2001;33:1096-1100. 4. Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr. 1998;17:216-234. 5. Williams MH, Branch JD. Creatine supplementation and exercise performance: an update. J Am Coll Nutr. 1998;17:216-234. 6. Balsom PD, Ekblom B, Soderlund K, et al. Creatine supplementation and dynamic high-intensity intermittent exercise. Scand J Med Sci Sport. 1993;3:143-149. 7. Mujika I, Padilla S. Creatine supplementation as an ergogenic acid for sports ...
Now Foods, Sports, Micronized Creatine Monohydrate, 1.1 lbs (500 g) - iHerb
Creatine is a compound that occurs naturally in the body, primarily in skeletal muscle. Creatines function is to serve as a precursor to Adenosine Triphosphate (ATP), the form of chemical energy used by all cells. Body stores of Creatine create a pool of readily available ATP for energy, which is necessary for fueling quick bursts of power and strength. Studies have demonstrated that Creatine supplementation can help to maintain existing muscle tissue, support the growth and development of lean mass, and promote optimal performance during short bouts of intense exercise. NOW® Creatine Monohydrate mixes easily and has no additives or preservatives. ...
AllNutrition Creatine Muscle Max - Protein Superstore
All nutrition creatine muscle max is the highest-quality micronized creatine monohydrate. Creatine increases physical performance in case of short burst of high-intensity exercises. Additionally, creatine muscle max has been enriched with amino acid taurine that is responsible for, among others, improvement of creatine
NOW Foods Creatine Monohydrate Powder 8 Ounces
NOW Creatine Monohydrate Powder 8 Ounces - Creatine Monohydrate is a naturally occurring compound found in the human body and obtained in the diet primarily from meat and fish. Creatine is a popular supplement among active individuals because of its ability to serve as an energy reservoir, especially during intense physical exertion. During short intense bursts of activity, the body breaks down adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and phosphate for energy. Creatine helps the body convert ADP back to ATP, providing greater amounts of ATP for energy, which may increase short-term endurance and strength. Creatine can also be stored for later use by cells creating the
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Creatine Nitrate vs Creatine Monohydrate - Mr Supplement Australia
Depression Research and Treatment Page 7
Authors: Réus GZ, Stringari RB, Gonçalves CL, Scaini G, Carvalho-Silva M, Jeremias GC, Jeremias IC, Ferreira GK, Streck EL, Hallak JE, Zuardi AW, Crippa JA, Quevedo J Abstract The present study evaluated mitochondrial respiratory chain and creatine kinase activities after administration of harmine (5, 10, and 15 mg/kg) and imipramine (10, 20, and 30 mg/kg) in rat brain. After acute treatment occurred an increase of creatine kinase in the prefrontal with imipramine (20 and 30 mg/kg) and harmine in all doses, in the striatum with imipramine (20 and 30 mg/kg) and harmine (5 an ...
Fish Oil Protects the Heart After PCI - Impella - Patient Blog
Percutaneous coronary intervention or PCI is a procedure that opens narrowed or blocked arteries. Some patients with severe coronary artery disease and reduced left ventricular ejection fraction may be candidates for Protected PCI, a PCI procedure using a miniature heart pump called the Impella 2.5.. A study found that people who were given omega-3 fatty acids 12 hours before their PCI procedure had lower levels of a heart biomarker after the PCI procedure. The only difference between the two groups was the addition of the 600 mg of docosahexaenoic acid (DHA) and 1200 mg of eicosapentaenoic acid (EPA) in a single fish oil pill. DHA and EPA are the primary omega-3 fatty acids needed for the body to function-especially for the immune system and the brain.. The heart biomarker studied was creatine kinase, an enzyme secreted by the heart that can indicate heart damage. Measurement of creatine kinase is routine after PCI procedures. Lower levels of creatine kinase indicate little or no heart damage ...
1998 - Creatine kinase-MB, cardiac troponin T, and myoglobin levels identified failed reperfusion after thrombolysis...
The results of the study by Stewart and colleagues confirm previous findings showing that successful coronary reperfusion leads to an accelerated increase in the levels of plasma markers of myocardial injury in patients treated with thrombolytic therapy for MI (1-3). Changes in the level of myoglobin have been found in almost all previous studies to be useful in detecting coronary reperfusion but may lack specificity because this marker is not cardiac-specific. Rapid increases in CKMB, MB isoforms, and troponin may offer enhanced specificity but may be less sensitive because early changes in levels of these compounds are less marked than those of myoglobin. Differences also exist in the performance of the available assays for these markers. This is important for development of clinical criteria for failure of reperfusion. Nonetheless, available data suggest that using ratios of 60- and 90-minute levels to the initial levels of some of these markers is reasonably accurate for assessing the ...
ZAP FATIGUE
Leg Immersion in Warm Water, Stretch-Shortening Exercise, and Exercise-Induced Muscle Damage. Skurvydas, Albertas; Kamandulis, Sigitas; Stanislovaitis, Aleksas; Streckis, Vytautas; Mamkus, Gediminas; Drazdauskas, Adomas // Journal of Athletic Training (National Athletic Trainers Associ;Nov/Dec2008, Vol. 43 Issue 6, p592 Context: Whether muscle warming protects against exercise-induced muscle damage is unknown. Objective: To determine the effect of leg immersion in warm water before stretch-shortening exercise on the time course of indirect markers of exercise-induced muscle damage. Design: Crossover trial.... ...
Acute Kidney Injury with Rhabdomyolysis: 25 Years Experience from a Tertiary Care Center
Objective: To describe patients presenting with acute kidney injury after rhabdomyolysis at a tertiary renal care center in Pakistan. Patients and Methods: An observational cohort of patients identified as having acute kidney injury (AKI) with rhabdomyolysis, which was diagnosed by rise in creatinine phosphokinase (CK) and lactate dehydrogenase (LDH) more than 4 times the reference range whereas AKI was defined according to RIFLE criteria. On ultrasonography, all patients had normal size non obstructed kidneys, and no other co morbid. Results: Between January1990 to December 2014, 334 patients with rhabdomyolysis and AKI registered to this hospital. Mean age was 28.22 ± 11.22 years with M:F ratio of 3.33:1. Mean values of CK and LDH were 597,749.790 ± 180,461.360 and 4077.026 ± 5050.704 U/L with reference range of 26 - 174 U/L and 91 - 180 U/L respectively. We divided the study population into 4 groups over timeline. Rhabdomyolysis etiology was divided in 3 groups; 1) traumatic, 2) non-traumatic
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In addition, creatine increases muscle glycogen, and this substance is also blows up muscles. Curiously, this is not about biochemical, and mechanical muscle growth, which, however, manifests itself slowly - not before a few months after starting creatine. Remember that the effect of creatine should be back more water. If along the way will you use diuretics, drink lots of coffee, cola, drink alcohol, in short, to dehydrate the body, growth effect of creatine is reduced to zero. Dosage: Take 3-4 grams of creatine per day. Part Creatine inevitably excreted in urine. To outwit the body, divide daily dose into 2-3 doses. Then creatine is assimilated more. Take creatine immediately after training, as well as after a meal. Particularly well Creatine is absorbed after a cocktail of 50 grams of carbohydrates with high glycemic level and 50 grams of protein. But do not try to stir creatine cocktail. First, drink a cocktail, and only then, after 20-30 minutes, take creatine. Filed under: ...