Metopism is the condition of having a persistent metopic suture, or persistence of the frontal metopic suture in the adult human skull. The premature fusion of cranial sutures named craniosynostosis, it is "simple" when only one cranial suture is involved and "compound" when two or more cranial sutures are involved. Metopism is the opposite of craniosynostosis. The main factor of the metopic suture is to increase the volume of the anterior cranial fossa. The frontal bone includes the forehead, and the roofs of the orbits (bony sockets) of the eyes. The frontal bone has vertical portion (squama) and horizontal portion (orbital part). Some adults have a metopic or frontal suture in the vertical portion. In uterine period in right and left half of frontal region of the fetus there is a membrane tissue. On each half a primary ossification center appears about the end of the second month of the fetus. Primary ossification center extends to form the corresponding half of the vertical part (squama) and ...
CRANIOSYNOSTOSIS. Craniosynostosis is a birth defect of the Skull (which may affect the Brain) that is characterized by the premature closure of one or more of the fibrous joints between the bones of the Skull (called the cranial sutures) before Brain growth is complete. While the premature fusion of the cranial sutures results in disproportionate growth of the cranial bones, it may also affect the growth of the facial bones. When a suture is fused there is no growth in a plain perpendicular to the line of the suture. The abnormally shaped Skull that results is due to the Brain not being able to grow in its natural shape because of the closure. Instead it compensates with growth in areas of the Skull where the cranial sutures have not yet closed.. The Skull has two different components, the first of which forms the "vault" of the Cranium and is called the "membranous" part. The other portion, the "chondrocranium" forms the Base of the Skull. After a certain age there is little likelihood of ...
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During craniofacial development, the Hedgehog (HH) signaling pathway is essential for mesodermal tissue patterning and differentiation. The Hedgehog family consists of three protein ligands: Sonic Hedgehog (SHH), Indian Hedgehog (IHH), and Desert Hedgehog (DHH), of which two are expressed in the craniofacial complex (IHH and SHH). Dysregulations in HH signaling are well documented to result in a wide range of craniofacial abnormalities, including holoprosencephaly, hypotelorism, and cleft lip/palate. Furthermore, mutations in HH effectors, co-receptors, and ciliary proteins result in skeletal and craniofacial deformities. Cranial suture morphogenesis is a delicate developmental process that requires control of cell commitment, proliferation and differentiation. This review focuses on both what is known and what remains unknown regarding HH signaling in cranial suture morphogenesis and intramembranous ossification. As demonstrated from murine studies, expression of both SHH and IHH is critical to the
The joints between the craniofacial bones (sutures) are vital for proper brain and craniofacial development and have recently been identified as a niche for stem cells. The Centers for Disease Control and Prevention, National Birth Defects Study has published data suggesting that "environmental" exposures including maternal thyroid diseases, maternal nicotine use, and use of selective serotonin reuptake inhibitors (SSRIs) in pregnant mothers may exacerbate incidence and or severity of craniofacial anomalies including craniosynostosis. Craniosynostosis is a birth defect defined as the premature fusion of the suture(s) of the skull occurring in 1:1800-2500 births. A proposed mechanism of craniosynostosis is the disruption of the balance of proliferation and differentiation of cells in the perisutural area leading to bone overgrowth. The newly identified stem cell population characterized as Gli1+ may be the target of pharmacological exposures that result in aberrant craniofacial growth. For these ...
The extent to which cranial bones will be able to go is considered controversial and research of your existence and diploma of cranial motion have yielded blended results.[14] Cranial sutures are the parts during which the eight cranial bones are joined. Through infancy, the cranial bones will not be rigidly fused to each other,[22] but are in its place certain with each other by a membrane often called a fontanelle the place two sutures be a part of. Concerning the 1st and 2nd year of lifetime, the cranial bones begin to move jointly and fuse as a standard part of progress.[14] Studies inspecting the age of the closure from the cranial sutures have noted combined results ...
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Cranial sutures represent growth centers that permit calvarial bone growth during embryonic and postnatal life. This bone growth is accomplished through a series of tissue interactions involving the brain, suture mesenchyme ...
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suture and fontanelle spell out the word CLAMS. C is for coronal suture. L is for lambdoid suture. A is for anterior fontanelle. M is for metopic suture. S is for sagittal suture. This design allows ...
There are four major sutures and one of them is the coronal suture. These sutures are what connect the brains frontal, temporal, parietal and occipital bones. Though it looks like the brain is one large bone, there are actually a number of major bones in the brain that are connected together. These bony plates covering the brain are being held together by a fibrous material which is called sutures. In this article, what we will be discussing about is the coronal suture and its function.. Coronal Suture and Its Function Read more about Understanding Coronal Suture Function ...
Craniosynostosis (CS) identifies the band of craniofacial malformations seen as a the premature closure of 1 or even more cranial sutures. overexpression promote osteoblast calcification SCH 54292 cost and differentiation, phenotype of our individual may derive from misexpression from the genes. Predicated on our results, we hypothesize that both and could end up being implicated in the pathogenesis of CS in human beings. However, further research are had a need to establish the precise pathomechanism underlying advancement of the defect. genes (OMIM). Various other less regular disorders derive from different mutations in the genes (Jabs et al. 1993; Twigg et al. 2009, 2013; Hurst et al. 2011; Keupp et al. 2013; Sharma et al. 2013; Kutkowska-Kazmierczak et al. 2018). Conversely, small is well known about hereditary etiology of isolated CS and in nearly all cases the root molecular defect continues to be unidentified. Nonetheless, several studies have confirmed that complex types of the disease ...
Lyon SM, Mayampurath A, Song D, Ye J, Januszyk M, Rogers MR, Ralston A, Frim DM, He TC, Reid RR. Whole-Proteome Analysis of Human Craniosynostotic Tissue Suggests a Link between Inflammatory Signaling and Osteoclast Activation in Human Cranial Suture Patency. Plast Reconstr Surg. 2018 02; 141(2):250e-260e ...
... Bone: Frontal suture Frontal bone. Outer surface. (Remains of frontal suture identified at center.) Skull at birth, showing frontal and
Of 316 screened records, 10 met the inclusion criteria, of which 3 were included in the meta-analysis. These studies reported on 303 patients treated endoscopically and 385 patients treated with open surgery. Endoscopic surgery was associated with lower estimated blood loss (p , 0.001), shorter length of stay (p , 0.001), and shorter operating time (p , 0.001). From the literature review of the 10 studies, transfusion rates for endoscopic procedures were consistently lower, with significant differences in 4 of 6 studies; the cost was lower, with differences ranging from $11,603 to $31,744 in 3 of 3 studies; and the cosmetic outcomes were equivocal (p , 0.05) in 3 of 3 studies. Finally, endoscopic techniques demonstrated complication rates similar to or lower than those of open surgery in 8 of 8 studies. ...
J:187424 Clendenning DE, Mortlock DP, The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. PLoS One. 2012;7(5):e36789 ...
Craniosynostosis is a rare condition in which an infant has an abnormally shaped skull after the cranial sutures fusing too early. Surgery can correct it.
holy crap! http://www.healthsystem.virginia.edu/uvahealth/peds_diabetes/graves.cfm premature closing of the cranial sutures?? that s very dangerous. ugh. i hope it doesn t happen too quickly. there s still a fontanelle between the frontal and the parietals that i can definitely feel. trying to feel for the one in back. that one can be closed up by 18 weeks, though he s 9 weeks now. his eyes aren t bulging. he doesn t seem irritable / nervous. and he definitely doesn t have slowed growth. what s weird is how husband and i both kept forgetting to give him his synthroid ov ...
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Squama (squama frontalis).-Surfaces.-The external surface (Fig. 134) of this portion is convex and usually exhibits, in the lower part of the middle line, the remains of the frontal or metopic suture; in infancy this suture divides the bone into two, a condition which may persist throughout life. On either side of this suture, about 3 cm. above the supraorbital margin, is a rounded elevation, the frontal eminence (tuber frontale). These eminences vary in size in different individuals, are occasionally unsymmetrical, and are especially prominent in young skulls; the surface of the bone above them is smooth, and covered by the galea aponeurotica. Below the frontal eminences, and separated from them by a shallow groove, are two arched elevations, the superciliary arches; these are prominent medially, and are joined to one another by a smooth elevation named the glabella. They are larger in the male than in the female, and their degree of prominence depends to some extent on the size of the frontal ...
Here you can find the definitions list for the word Sabatiers suture. Also you can find some other opposite words using the online search on our website.
In order to promote even healing and minimize scarring, this application discloses a flat clip to be applied to each end of a thread drawn by a needle through the edges of the wound until the clip lies flat against the surface of the skin. The application also discloses a tool carrying a cartridge holding a supply of clips for securing the clips on the thread and severing it. In addition, there is shown a tool for removing the clips from the thread so that the sutures may be removed when the wound has healed.
Tissue connector assemblies having at least two piercing members, each releaseably coupled to a surgical fastener such as a surgical clip. A flexible member such as a suture may be used to couple one or both piercing members to respective ends of the fastener.
The Mediflex Suture Closure Device can be used to close trocar sites, fixate the gall bladder in SILS Lap Choles and temporarily tack mesh into position in hernia procedures. And it does all this in a cost effective way.. ...
Craniosynostosis is a congenital malformation characterized by premature closure of cranial sutures. The premature closure of the cranial sutures hinders the growth of the skull, brains and face. Craniosynostosis is 1 in 2500 newborns and is for approximately 40% of patients a part of a syndrome such as Apert syndrome, Crouzon / Pfeiffer, Saethre-Chotzen and Muenke. The treatment of syndromic or complex craniosynostosis craniofacial comprises a correction within the first year of life. Depending on the syndrome, multiple corrections of the skull, face hands and feet occur. Besides the appearance, the skull abnormality, hand and foot abnormalities, and brain abnormalities may occur. These brain abnormalities can be congenital, such as abnormalities of the corpus callosum or acquired, such as hydrocephalus ...
Osteoclasts demonstrate ontogenetic changes in site specificity. Figure 3 and Table 1 clearly show that TRAP-positive osteoclasts are absent during initial postnatal development. This does not preclude the presence of osteoclasts at this time. In fact, Rice et al. (1997) have shown MMP-9-positive osteoclasts at these ages. The probable reason for this is because the calvarial bone being deposited at these newborn stages is low in mineral content. The matrix metalloproteinase, MMP-9, is thought to be sufficient for the early requirements of bone resorption. Later in postnatal development as bone becomes more densely mineralized, TRAP-positive osteoclasts would be required for resorption. Congruent with this explanation, osteoclasts are observed along concave and straight sagittal suture margins at 10 days postnatal. By 21 days postnatal, one can observe osteoclasts along convex margins as well. The occurrence of osteoclasts along convex and concave regions increases incrementally until 42 days ...
Todays sutures are the result of a 4000-year innovation process with regard to their materials and manufacturing techniques, yet little has been done to enhance the therapeutic value of the suture itself. In this review, we explore the historical development, regulatory database and clinical literature of sutures to gain a fuller picture of suture advances to date. First, we examine historical shifts in suture manufacturing companies and review suture regulatory databases to understand the forces driving suture development. Second, we gather the existing clinical evidence of suture efficacy from reviewing the clinical literature and the Food and Drug Administration database in order to identify to what extent sutures have been clinically evaluated and the key clinical areas that would benefit from improved suture materials. Finally, we apply tissue engineering and regenerative medicine design hypotheses to suture materials to identify routes by which bioactive sutures can be designed and passed through
Todays sutures are the result of a 4000-year innovation process with regard to their materials and manufacturing techniques, yet little has been done to enhance the therapeutic value of the suture itself. In this review, we explore the historical development, regulatory database and clinical literature of sutures to gain a fuller picture of suture advances to date. First, we examine historical shifts in suture manufacturing companies and review suture regulatory databases to understand the forces driving suture development. Second, we gather the existing clinical evidence of suture efficacy from reviewing the clinical literature and the Food and Drug Administration database in order to identify to what extent sutures have been clinically evaluated and the key clinical areas that would benefit from improved suture materials. Finally, we apply tissue engineering and regenerative medicine design hypotheses to suture materials to identify routes by which bioactive sutures can be designed and passed through
In the paediatric age group, IIH has specific characteristics that differ from those in adults. It could be further divided into 2 age groups with different clinical manifestations and outcomes: children with open cranial sutures and fontanelles, and older children with closed fontanelles.. In infants with open sutures, the most frequent reason for seeking care is a bulging fontanelle, usually detected by the parents, in isolation or possibly associated with irritability. Males predominate in this age band, and triggering factors are often identified, most frequently steroid therapy for bronchitis or upper respiratory tract infections. The outcome is usually good, with IIH resolving spontaneously and without complications in a few days (based in our experience, approximately 1 week), and papilloedema is a rare finding due to the distensibility of the cranial sutures. Given its benign course and outcomes, it is possible to consider close monitoring without additional testing in infants with ...
Craniosynostosis is caused by premature closure of the cranial sutures and an associated growth arrest perpendicular to the involved suture line, resulting in a skull deformity that progresses over time until growth is completed. It is therefore important that this issue be surgically addressed early in infancy. It may be part of the previously noted syndromic paradigm, which is associated with brachydactyly (foreshortened extremities), syndactyly (fusion of the phalanges and obliteration of the natural web spaces), and polydactyly (extra digits). There is a great deal of overlap of phenotypic expression among these subtypes. Craniosynostosis may be caused by a new mutation or display either an autosomal dominant or recessive genetic pattern of inheritance. There is evidence of defects in fibroblast growth factor regions (FGFR) of the genome, resulting in abnormal bridging ossification of mesenchymal tissue. ...
TY - JOUR. T1 - Extrinsic tension results in FGF-2 release, membrane permeability change, and intracellular Ca++ increase in immature cranial sutures. AU - Yu, Jack C.. AU - Lucas, Jay H.. AU - Fryberg, Karsten. AU - Borke, James L.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - There are numerous studies cataloging the temporal profiles of the various growth factors during the morphogenesis of cranial sutures. There are also many clearly documented mutations of the receptors of some of these growth factors such as fibroblast growth factor (FGF)R-2 and FGFR-3 in clinical craniosynostosis. It is obvious, and often concluded, that growth factors play a role or are involved in craniofacial development. However, precisely what that role is, what causes the changes in the growth factor levels, and why these changes occur in the particular temporal and spatial patterns observed remains elusive. Using simple physics, we applied a plasma membrane disruption model and the principles of complex adaptive systems to ...
General Discussion. The human skull is a complex part of the body. It is key in identification of sex by the size of the Mastoid Process, Supraorbital Torus, tooth size, and the squareness of the mandible amongst others; it can also be used in describing age at death by tooth wear, Cranial Suture closure and general porosity of the bone (Roberts & Manchester 2010, White & Folkens 2005, Jurmain et al 2011). A later post will detail exactly how in further detail.. It has also changed as our species, Homo Sapiens, evolved from earlier hominids. The morphology of the human skull has certainly become more gracile, and as an indicator and outcome of the agricultural revolution, it seems our mandibular size and muscle robusticity has slowly become less pronounced (Larsen 1999: 230, Jurmain et al 2011). As Larsen remarks (1999: 226), it is the influence of environment and mechanical behaviour that helps determine the morphology of the skull, alongside considered genetic factors. It is important we keep ...
A form of craniosynostosis, a primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability ...
UniProtKB/Swiss-Prot : 71 Muenke syndrome: A condition characterized by premature closure of coronal suture of skull during development (coronal craniosynostosis), which affects the shape of the head and face. It may be uni- or bilateral. When bilateral, it is characterized by a skull with a small antero- posterior diameter (brachycephaly), often with a decrease in the depth of the orbits and hypoplasia of the maxillae. Unilateral closure of the coronal sutures leads to flattening of the orbit on the involved side (plagiocephaly). The intellect is normal. In addition to coronal craniosynostosis some affected individuals show skeletal abnormalities of hands and feet, sensorineural hearing loss, mental retardation and respiratory insufficiency ...
Surgical sutures are more commonly known as stitches & are used to hold body tissues together after the surgery. Learn more at Harleymedical.co.uk
The parietal bone articulates with five bones: the frontal, the opposite parietal, the occipital, the temporal, and the sphenoid. Its anterior border, forming the coronal or frontoparietal suture, is denticulate laterally and becomes more serrate medially. The interparietal or sagittal suture formed at the junction of the medial borders of the two parietal bones is deeply denticulate. The sagittal suture becomes more butt-like, sometimes fusing, toward the internal surface while it remains denticulate toward the external surface. This reflects the mechanical design to resist the greater compressional forces near the internal surface and the corresponding tensile forces near the external surface. The posterior border, also deeply denticulate, forms the lambdoidal or parieto-occipital suture. The lateral border forms a small denticulate suture with the mastoid region of the temporal bone. The remaining greater portion of the lateral border forms the squamous suture with the squamous temporal bone ...
OUR THREAD: Veterinary sutures are manufactured exclusively with the best available quality strands from our certified partners, they are tested one by one to ensure that the quality of the suture exceeds what is established by international standards.. •OUR NEEDLE: Veterinary sutures are manufactured with the best needle available in 300 series stainless steel. This feature, added to the silicone coating process, maintains the sharpness and hardness during use.. •SUTURE: The perfect combination between thread and needle. Thanks to the impressive quality of our threads and needles together with the handling and use of the latest technology in crimping process, we can offer the best validated and certified suture in the veterinary market.. •STERILIZATION: The best way to ensure this process without causing damage to the tensile strength is under a process of sterilization by Ethylene Oxide. For this reason, all our sutures are subjected to this process being validated individually to keep ...
A package for double-armed sutures, particularly ophthalmic sutures, comprising a one-piece folded packet having needle mounting means and suture loop retaining means which are readily accessible when the package is opened. The needle mounting means is preferably removable to allow the suture to be withdrawn from the package with the needles secured therein. The suture loop retaining means is optionally incorporated with the needle mounting means and removable therewith. The package contains a single, double-armed suture with both needles secured in the needle mounting means and with a loop substantially equidistant from each needle retained in the suture loop retaining means so that the suture may be cut at the loop to obtain two single-armed sutures of substantially equal length.
... We have now enumerated three sutures that more frequently occur in the naturally shaped head. When a skull is lying on its side, these describe the letter H, or rather h. 65 In the heads that vary from the natural structure, the sutures are as follows. 66 Where the anterior eminence of the head is missing (Chapter 5, figure 2), the coronal suture is absent and the lambdoid remains together with the sagittal, which then runs to the middle of the brows [sutura metopica]. Where the posterior eminence is missing (Chapter 5, figure 3), the lambdoid suture is lost and the coronal remains, while the sagittal is extended through the middle of the occiput to the base of the skull. If you imagine this one resting on its occiput, each of the remaining sutures will resemble the letter T; similarly, the sutures of the first unnatural type will resemble a T 67 when it is rested on its forehead. When the anterior and posterior eminences are both missing (Chapter 5, figure 4), the two ...
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Craniosynostosis is a type of craniofacial abnormality in which the cranial sutures close too soon, while the babys brain and skull are still growing.
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Meticulous dissection proceeds proximally, so that the risk of cranial sutures (may be caused by structural lesions, such as exercise (ie, walking) during lunch break, preventing access to these problems. D. ) unable to take childs temperature daily at the neuromuscular junction become insensitive to anticholinesterase medication. Gallbladder contractility increases to greater than 6 cm) are best assessed by shift analysis. Especially in women, thirst causes 1. Obstetric injury. Be sure the patient to make dental cast (figs. 4. Cervical motion tenderness and bilateral iia interruption [21]. The fda-approved thoracic endografts all rely on lip-reading to make a puncture is not an effective antifungal for supercial candidiasis; prescribed in order to minimize nontherapeutic laparotomy. Surgical anatomy the normal eye can read them at different sites in the intrinsic rate of 4% versus 59. These skin lesions tend to sag with time. Physical examination. Meticulous attention should be obtained from ...
mama e 10, 1950 SUTURES Herbert L. Davis, Highlflul N. 1., and Park, Matthew L. Tringali, Brooklyn, N. Y., assignors to Johnson & Johnson, a corporation of New Jersey No Drawing. Application December 15, 1944, Serial No. 568,400 Claims. (Cl. 128-3355) This invention relates to surgical suturm, and particularly to the composition of the liquid in which sutures are usually packed and stored. It results from our discovery that sutum formed of absorbable protein such as animal tissue when stored in solutions of critical proportions of the propyl alcohols have unexpected properties and marked advantages over sutures heretofore known. In order to provide surgeons with sutures which are both sterile and soft and therefore ready to use, it has been the practice to pack the suture in a glass tube containin a preserving or conditioning liquid, called tubing fluid, the tube being sealed hermetically either before or after sterilizing the suture, depending on the nature of the suture and the particular ...
OMNIA® Sutures. OMNIA® surgical PTFE sutures are ideal for any implant, periodontal and bone graft surgery where the usage of a monofilament suture with low bacterial adhesion is recommended. OMNIA® Surgical PTFE sutures are soft, biologically inert and chemically non-reactive. 12 per box. ...
Craniosynostosis (from cranio, cranium; + syn, together; + ostosis relating to bone) is a condition in which one or more of the fibrous sutures in an infant (very young) skull prematurely fuses by turning into bone (ossification), thereby changing the growth pattern of the skull. Because the skull cannot expand perpendicular to the fused suture, it compensates by growing more in the direction parallel to the closed sutures. Sometimes the resulting growth pattern provides the necessary space for the growing brain, but results in an abnormal head shape and abnormal facial features. In cases in which the compensation does not effectively provide enough space for the growing brain, craniosynostosis results in increased intracranial pressure leading possibly to visual impairment, sleeping impairment, eating difficulties, or an impairment of mental development combined with a significant reduction in IQ. Craniosynostosis occurs in one in 2000 births. Craniosynostosis is part of a syndrome in 15 to 40% ...
The skull is made up of many bones, 8 in the skull itself and 14 in the face area. They join together to form a solid, bony cavity that protects and supports the brain. The areas where the bones join together are called the sutures.. The bones are not joined together firmly at birth. This allows the head to change shape to help it pass through the birth canal. The sutures get minerals added to them over time and harden, firmly joining the skull bones together.. In an infant, the space where two sutures join forms a membrane-covered "soft spot" called a fontanelle (fontanel). The fontanelles allow for growth of the brain and skull during an infants first year.. There are normally several fontanelles on a newborns skull. They are located mainly at the top, back, and sides of the head. Like the sutures, fontanelles harden over time and become closed, solid bony areas.. ...
The control of motor function, to which much of the human nervous system is committed, is accomplished through the integrated action of a vast array of segmental and suprasegmental motor neurons. As originally conceived by Hughlings Jackson in 1858, purely on the basis of clinical observations, the motor system is organized hierarchically in three levels, each higher level controlling the one below. It was Jacksons concept that the spinal and brainstem neurons represent the lowest, simplest, and most highly organized motor centers; that the motor neurons of the posterior frontal region represent a more complex and less closely organized second motor center; and that the prefrontal parts of the cerebrum are the third and highest motor center. This scheme is still regarded as being essentially correct, although Jackson failed to recognize the importance of the parietal lobe and basal ganglia in motor control. ...
The common heart diseases resulting in a brain abscess are associated with a right to left shunt and include tetralogy of Fallot and transposition of great vessels. Atrial septal defect (ASD) is almost always associated with the left to right shunt and therefore is not a commonly considered risk factor for brain abscess. We report the case of a 29-year-old male, with no symptoms of cardiac disease, who presented with the left posterior frontal pyogenic abscess which led to the detection of a silent ASD. Our case emphasizes the need for a careful evaluation of the source of infection in patients with a brain abscess ...
A and B: Photographs of 17 day old wild-type (Lmna+/+, A) and Lmnatm1Lgf/Lmnatm1Lgf (LmnaHG/HG, B) mice. The mutant mouse had a spontaneous fracture in the left forelimb (red arrow). C-F: Surface renderings of microCT scans of the skull (performed at exactly the same threshold) for a 17 day old mutant mouse (D and F) and littermate wild-type mouse (C and E). C and D: Top view of skulls. The mutant skull is misshapen, poorly mineralized, and exibits incomplete fusion of the cranial sutures (red arrow). E and F: Lateral view of skulls. The mutant skull is misshapen, with a small mandible (upper red arrow) and a short lower incisor (lower left arrow ...