CBSRP : Coxiella burnetii, the causative agent of Q fever, is a small obligately intracellular bacterium, which is associated with animals. It is acquired through aerosol exposure and generally causes mild respiratory disease. A small number of acute cases advance to a chronic infection, which typically manifests as endocarditis. Left untreated, Q fever endocarditis may be fatal. Serologic and histopathologic studies may be nonspecific and subjective, respectively, limiting usefulness for patient diagnosis.   Evaluation of infected tissue, blood, or serum using PCR may be a useful tool for diagnosing some cases of Coxiella burnetii infection. Mayo Medical Laboratories has developed a real-time PCR test that rapidly detects Coxiella burnetii DNA in clinical specimens by targeting a sequence of the shikimate dehydrogenase gene (aroE) unique to Coxiella burnetii.
TY - JOUR. T1 - Dynamics of relationship between the presence of Coxiella burnetii DNA, antibodies, and intrinsic variables in cow milk and bulk tank milk from Danish dairy cattle. AU - Angen,Øystein. AU - Ståhl,Marie. AU - Agerholm,J. S.. AU - Christoffersen,Anna-Bodil. AU - Agger,J. F.. N1 - Copyright 2011 American Dairy Science Association.. PY - 2011. Y1 - 2011. N2 - Milk samples of 12 Danish dairy herds were collected 3 times during an 11-mo period and tested for Coxiella burnetii DNA by real-time PCR, detecting the IS1111 element, and for the presence of antibodies against the bacterium by ELISA. On average, 25% of 1,514 samples were seropositive and 32% were positive for C. burnetii DNA. Among the 485 DNA-positive samples, quantification cycle values ranging from 15.8 to 37.8 were found. Test sensitivity did not increase after DNA extraction from the cream fraction compared with full milk. The relationship between antibody levels and bacterial shedding was investigated among 166 cows ...
BACKGROUND: Prior to the 2007-2010 Q fever epidemic in the Netherlands, the seroprevalence of antibodies against Coxiella burnetii in the general population was 1.5%, which is low compared to other countries. We aimed to determine the seroprevalence after the Q fever epidemic among people living in the affected area, compare ... read more the seroprevalence with the incidence of Q fever notifications during the 2007-2010 Q fever epidemic, and to identify farm exposures associated with having antibodies against C. burnetii. METHODS: During the period March 2014-February 2015, residents aged 18-70 years from two provinces were invited by general practitioners to complete a questionnaire on their symptoms and personal characteristics and to submit a blood sample. We used the mandatory provincial database of livestock licences to calculate distance to farms/farm animals for each participant. To compare ELISA-positive participants for C. burnetii antibodies with those who were negative, we calculated ...
Coxiella burnetii is an intracellular bacterial pathogen that causes Q fever. Infected pregnant goats are a major source of human infection. However, the tissue dissemination and excretion pathway of the pathogen in goats are still poorly understood. To better understand Q fever pathogenesis, we inoculated groups of pregnant goats via the intranasal route with a recent Dutch outbreak C. burnetii isolate. Tissue dissemination and excretion of the pathogen were followed for up to 95 days after parturition. Goats were successfully infected via the intranasal route. PCR and immunohistochemistry showed strong tropism of C. burnetii towards the placenta at two to four weeks after inoculation. Bacterial replication seemed to occur predominantly in the trophoblasts of the placenta and not in other organs of goats and kids. The amount of C. burnetii DNA in the organs of goats and kids increased towards parturition. After parturition it decreased to undetectable levels: after 81 days post-parturition in goats and
Summary Experimental Coxiella burnetii infection in deer mice, desert wood rats, Montane meadow mice, Ord kangaroo rats, pinyon mice, and laboratory white mice was studied, employing three criteria: 28-day Phase II complement fixing antibody responses, splenomegaly, and tissue infection. Infection in guinea pigs was determined by fever response in addition to the above. All criteria gave similar ID50 values with the exception of splenomegaly, which was absent in some animal species. All tested animals were shown to be readily susceptible to intraperitoneal Q fever infection, the laboratory animals being more susceptible than the wild rodents. Disease manifestations were mild in all animals.
The objective of this study was to investigate the prevalence of Coxiella burnetii in two domestic ruminant species (cattle and sheep) and the western grey kangaroo (Macropus fuliginosus) in Western Australia (WA). The IDEXX CHEKiT Q Fever ELISA and CFT were used to test sera from 50 sheep and 329 head of cattle for anti- C. burnetii antibodies and 343 kangaroo sera were tested using an indirect ELISA developed specifically for this study. Faecal or urine samples collected from the same animals were tested with two PCR assays to identify active shedding of C. burnetii in excreta. Only two of the 379 ruminant sera had detectable levels of anti- C. burnetii antibodies according to the ELISA while the CFT did not detect any positive samples. In contrast 115 of the 343 western grey kangaroo serum samples were positive when tested with the antibody-ELISA. The first qPCR assay, targeting the IS1111a element, identified 41 of 379 ruminant and 42 of 343 kangaroo DNA samples as positive for C. burnetii ...
Coxiella burnetii symptoms, causes, diagnosis, and treatment information for Coxiella burnetii (Q fever) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
Coxiella burnetii, a gram-negative obligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterrorism. Distinct genomic groups of C. burnetii are revealed by restriction fragment-length polymorphisms (RFLP). Here we comprehensively define the genetic diversity …
Q fever caused by Coxiella burnetii is transmitted to humans by inhalation of aerosols from animal birth products. Q fever in pregnancy is suspected to be a potential cause of fetal and maternal morbidity and fetal mortality but the pathogenesis is poorly understood, and even in Q fever endemic areas, the magnitude of a potential association is not established. We aimed to examine if presence of antibodies to C. burnetii during pregnancy or seroconversion were associated with adverse pregnancy outcomes. The Danish National Birth Cohort collected blood samples and interview data from 100,418 pregnant women (1996-2002). We sampled 397 pregnant women with occupational or domestic exposure to cattle or sheep and a random sample of 459 women with no animal exposure. Outcome measures were spontaneous abortion, preterm birth, birth weight and Small for Gestational Age (SGA). Blood samples collected in pregnancy were screened for antibodies against C. burnetii by enzyme-linked immunosorbent assay (ELISA).
Abstract. We used a seroepidemiologic study to estimate Q fever (Coxiella burnetii) seroprevalence, seroincidence, and risk factors for seroconversion in two deployed military populations in 2005. The first study group resided in an area with a known Q fever outbreak history (Al Asad, Iraq). Of this population, 7.2% seroconverted for an incidence rate of 10.6 seroconversions per 1,000 person-months. The second population included personnel transiting through Qatar on mid-deployment leave from southwest/central Asia. In this group, we found 2.1% prevalence with 0.92 seroconversions per 1,000 person-months. However, no significant risk factors for Q fever seroconversion were found in either population.
The intervening sequence (IVS) of Coxiella burnetii, the agent of Q fever, is a 428-nt selfish genetic element located in helix 45 of the precursor 23S rRNA. The IVS element, in turn, contains an ORF that encodes a hypothetical ribosomal S23 protein (S23p). Although S23p can be synthesized in vitro in the presence of an engineered E. coli promoter and ribosome binding site, results suggest that the protein is not synthesized in vivo. In spite of a high degree of IVS conservation among different strains of C. burnetii, the region immediately upstream of the S23p start codon is prone to change, and the S23p-encoding ORF is evidently undergoing reductive evolution. We determined that IVS excision from 23S rRNA was mediated by RNase III, and IVS RNA was rapidly degraded, thereafter. Levels of the resulting 23S rRNA fragments that flank the IVS, F1 (~1.2 kb) and F2 (~1.7 kb), were quantified over C. burnetiis logarithmic growth phase (1-5d). Results showed that 23S F1 quantities were consistently higher
Genetic variations in innate immunity genes affect response to Coxiella burnetii and are associated with susceptibility to chronic Q ...
McCaul T.F., Williams J.C. and Thompson H.A. (1991) Electron microscopy of Coxiella burnetii in tissue culture. Induction of cell types as products of developmental cycle.. Acta Virologica, 35 6: 545-556. ...
There are comments on PubPeer for publication: Activation of protein tyrosine kinases by Coxiella burnetii: role in actin cytoskeleton reorganization and bacterial phagocytosis (2001)
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Characterization of the GDP-D-Mannose Biosynthesis Pathway in Coxiella burnetii: The Initial Steps for GDP-β-D-Virenose Biosynthesis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
This is a collaborative project between veterinary and medical colleagues from NSW and Queensland to determine the importance of Q fever in the veterinary community as well as the broader Australian population. It brings together veterinarians from the University of Sydney (Assoc. Prof. Jacqui Norris, Dr Katrina Bosward, Dr Navneet Dhand), Charles Sturt University (Dr Jane Heller), the University of Queensland (Dr Rowland Cobbold) and James Cook University as well as medical colleagues from Sydney (Dr Nicholas Wood, Professor Peter McIntyre, Dr Heather Gidding, Professor Dominic Dwyer), the New England/Hunter region (Prof David Durrheim, Assoc. Prof. Stephen Graves), Brisbane (Professor Michael Nissen, Mrs Sarah Tozer, Dr Theo Sloots) and north east Queensland (Townsville, Dr Peter Massey).. Q fever is a ubiquitous zoonotic disease of worldwide importance caused by the bacterium Coxiella burnetii. It is classified as a category B bioterrorism agent and is a significant cause of acute and chronic ...
Q fever is caused by the bacterium Coxiella burnetii and has both acute and chronic forms. The acute disease is a febrile illness often with headache and myalgia that can be self-limiting, whereas the chronic disease typically presents as endocarditis and can be life threatening. The normal therapy for the acute disease is a 2 week course of doxycycline, whereas chronic disease requires 18-24 months of doxycycline in combination with hydroxychloroquine. Alternative treatments are used for pregnant women, young children and those who cannot tolerate doxycycline. Doxycycline resistance is rare, but has been reported. Co-trimoxazole is a currently recommended alternative treatment, but quinolones, rifampin and newer macrolides may also provide some benefit ...
En citoloxía denomínase fagosoma un vacúolo formado arredor dunha partícula que foi absorbida pola célula por fagocitose. Son típicos da célula animal. O vacúolo fórmase pola fusión da membrana celular arredor da partícula. O fagosoma é un compartimento celular no cal poden dixerirse e destruírse microorganismos patóxenos. Os fagosomas fusiónanse con lisosomas no seu proceso de maduración, formando fagolisosomas. Algunhas bacterias patóxenas que chegan ao interior da célula ao seren fagocitadas, poden reproducirse no interior do fagosoma ou mesmo no interior do fagolisosoma, como é o caso da bacteria Coxiella burnetii.[1] Outras pasan ao citoplasma antes de que o fagosoma se fusione co lisosoma, como sucede con Rickettsia[2]. Moitas micobacterias, entre as que se inclúe Mycobacterium tuberculosis[3][4] e a Mycobacteria avium paratuberculosis[5], manipula ao seu hospedador, un macrófago, para impedir que os lisosomas cargados de ácido nitroso se fusionen cos fagosomas e ...
The scope and overall interpretation of our report on the re-evaluation of the fixed, paraffin-embedded tissue samples taken at patient BIs autopsy are necessarily limited by the absence of diagnostic results of any serological or other tests for candidate infective organisms at the time of the "viral encephalitis" in 1986 (see review [17]). Nevertheless, taken together, the extended laboratory tests with C.b. specific monoclonal antibodies and PCR (COM1 and IS1111a genes) on a range of post mortem specimens suggest that the most compelling and coherent explanation of BIs illness from 1986 to 1996, is one of a severe attack of primary Q fever and a subsequent multisystem organ dysfunction with dissemination of the coxiella throughout the body, ending in 1996 with cardiac and cerebral dysfunction i.e., a complex, severe idiopathic illness labelled descriptively at the time as "post (viral) infection fatigue syndrome" (PIFS).. An epidemiological and clinical association between ...
Catalyzes the reductive methylation of 2-deoxyuridine-5-monophosphate (dUMP) to 2-deoxythymidine-5-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
The focus of our research is to understand the molecular and cellular events that enable microbial pathogens to evade host defense mechanisms. In particular, we are interested in how bacteria that replicate inside mammalian cells create specialized vacuoles that support pathogen replication. We have been using Legionella pneumophila and Coxiella burnetii as model pathogens to study this process. We have been characterizing a type IV secretion system called Dot/Icm that delivers bacterial effector proteins into the eukaryotic host cell cytosol. The goals of this research are to determine the mechanism by which these bacterial effector proteins regulate phagosome maturation, modulate host immunity, and subvert eukaryotic cell functions.. Specialized Terms: Molecular; Cellular; Microbial pathogens; Bacteria; Vesicular transport; Legionella pneumophila; Coxiella burnetii; Macrophages; Protozoan; ...
AmJTrop Med Hyg 2009, 81:67-74. 22. Willems H, Thiele D, Frolich-Ritter R, Krauss H: Detection of Coxiella burnetii in cows check details milk using the polymerase chain reaction (PCR). Zentralbl Vet B 1994, 41:580-587. 23. Berri M, Laroucau K, Rodolakis A: The detection of Coxiella burnetii from ovine genital swabs, milk and fecal samples by the use of a single touchdown polymerase chain reaction. Vet Microbiol 2000, 72:285-293.PubMedCrossRef 24. Barandika JF, Hurtado A, García-Esteban C, Gil H, Escudero R, Barral M, Jado I, Juste RA, Anda P, García-Pérez AL: Tick-borne zoonotic bacteria in wild and domestic small mammals in northern Spain. Appl Environ Microbiol. 2007, 73:6166-6171.PubMedCrossRef 25. Jado I, Escudero R, Gil H, Jiménez-Alonso MI, Sousa R, García-Pérez AL, Rodríguez-Vargas M, Lobo B, Anda P: Molecular method for identification of Rickettsia species in clinical and environmental samples. J Clin Microbiol 2006, 44:4572-4576.PubMedCrossRef 26. Montejo-Baranda M, ...
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Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar ...
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR ...
1. A 21-day whole body x-irradiation LD50 was determined for guinea pigs, white mice and deer mice. As measured by post-exposure deaths, guinea pigs were most susceptible (LD50: 163 r), white mice less susceptible (LD50: 431 r) and deer mice least susceptible (LD50: 588 r) to the irradiation. 2. In a pilot rickettsiae study, Coxiella burnetii was shown to persist for over 12 weeks in kidneys of guinea pigs and reproductive tract and kidneys of white mice. Fecal material and urine in guinea pigs, white mice and deer mice were infectious for three weeks. The organism persisted a total of six week in deer mouse spleen, kidneys and liver. 3. Whole body x-irradiation in dosages slightly less than or greater than the 21-day LD50 caused a reactivation of C. burnetii infection in guinea pigs, white mice, and deer mice infected three months previously. This reactivation was determined by demonstrating infectious quantities of rickettsiae in various tissues and in urine and feces in these animals, as ...
Vilibić-Čavlek, Tatjana and Kučinar, Jasmina and Kaić, Bernard and Vilibić, Maja and Pandak, Nenad and Barbić, Ljubo and Stevanović, Vladimir and Vraneš, Jasmina (2015) Epidemiology of hepatitis C in Croatia in the European context. World Journal of Gastroenterology, 21 (32). pp. 9476-93. ISSN 1007-9327 Kaić, Bernard (2012) Utjecaj medikamentnog liječenja na trajanje opsežnih lokalnih reakcija nakon primjene kombiniranih acelularnih cjepiva protiv pertusisa [Effect of medication on the duration of large local reactions following administration of combination acellular pertussis vaccines]. PhD thesis, Sveučilište u Zagrebu. Vilibić-Čavlek, Tatjana and Kučinar, Jasmina and Ljubin-Sternak, Sunčanica and Kolarić, Branko and Kaić, Bernard and Lazarić-Stefanović, Lorena and Hunjak, Blaženka and Mlinarić-Galinović, Gordana (2012) Prevalence of Coxiella burnetii antibodies among febrile patients in Croatia, 2008-2010. Vector Borne and Zoonotic Diseases, 12 (4). pp. 293-6. ISSN ...
CIDRAP News) The genetic blueprint of Coxiella burnetii, a category B bioterrorism agent that causes Q fever, has been decoded and analyzed, the National Institute of Allergy and Infectious Diseases (NIAID) announced this week. ...
Dr. Malinda Fitzgerald, Professor of Biology and Alpha Chi faculty advisor, attended the National Alpha Chi Convention in Chicago in March with Johnnie Huddleston. Johnnie graduated with her BFA from CBU while going part time and working in the business office. She is interested in applying to Masters programs in digital media. Johnnie presented a talk on "My Vision of Art" and placed on the alternate list for the national scholarship to graduate school from AX. This is a very competitive scholarship and if anyone doesnt accept she is next on the list. Dr. Fitzgerald is serving as the president of Regional III for Alpha Chi and it has over 78 schools and is one of the largest regions. ***. This piece on the Science Fair is from Wendy Sumner-Winter, Sr. Director of External Affairs and Advancement for CBU. On Saturday, Feb. 28, students from high schools throughout the Memphis area gathered at Christian Brothers University (CBU) to participate in the Science Olympiad. This years Olympiad ...
The increases in MAP and HR recorded via telemetry during the first week after CBU are very similar to results published previously based on daily recordings with the dog resting quietly in a sling under laboratory conditions (28). The effects of CBU on PRA were also replicated; PRA was elevated on some days during the week following CBU but never suppressed below control levels. Furthermore, we also observed a significant increase in plasma NE in response to CBU. All of these responses are compatible with the hypothesis that CBU caused an increase in sympathetic outflow. However, contrary to our expectations, the initial increases in MAP, HR, and plasma NE were not sustained. Plasma NE and HR declined to control levels by the third week after CBU (Figs. 4 and 7). There was also a decline in MAP over the same time period, but MAP stabilized at a level that averaged 10 ± 3 mmHg above control during the third to fifth weeks after CBU (Fig. 2). There are a number of possibilities that could ...
Q-fever, a rare infection caused by the Coxiella burnetii organism, has been confirmed in workers at the Scotbeef Meat Processing Company in Bridge of Allan.
Time Course of the Levels of Antibodies to Coxiella burnetii and Detection of C. burnetii-DNA in Three Imported Cases of Acute Q ...
9. O. Duron, V. Noël, K. D. McCoy, M. Bonazzi, K. Sidi-Boumedine, O. Morel, F. Vavre, L. Zenner, E. Jourdain, P. Durand, C. Arnathau, F. Renaud, J.F. Trape, A. S. Biguezoton, J. Cremaschi, M. Dietrich, E. Léger, A. Appelgren, M. Dupraz, E. Gomez-Diaz, G. Diatta, G.K. Dayo, Hassane Adakal, S. Zoungrana, L. Vial and C. Chevillon. "The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii". PLOS Pathogen. 2015. May 15. DOI:10.1371/journal.ppat. ...
9. O. Duron, V. Noël, K. D. McCoy, M. Bonazzi, K. Sidi-Boumedine, O. Morel, F. Vavre, L. Zenner, E. Jourdain, P. Durand, C. Arnathau, F. Renaud, J.F. Trape, A. S. Biguezoton, J. Cremaschi, M. Dietrich, E. Léger, A. Appelgren, M. Dupraz, E. Gomez-Diaz, G. Diatta, G.K. Dayo, Hassane Adakal, S. Zoungrana, L. Vial and C. Chevillon. "The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii". PLOS Pathogen. 2015. May 15. DOI:10.1371/journal.ppat. ...
A febre Q é uma zoonose ubíqua provocada por uma rickettsia, Coxiella burnetii, ocorrendo como casos esporádicos em zonas de pastagem de ovinos e caprinos e podendo ser responsáveis por surtos humanos (1). O modo de transmissão predominante é a inalação de aerossóis infectados provenientes do meio ambiente (solo, palha, lã), contaminado após o período de parto do gado ovino, caprino ou bovino (1). Neste artigo, descrevemos um surto urbano de febre Q que ocorreu de Março a Maio de 1996, em Briançon, uma cidade de 12 000 habitantes, situada numa zona de pastagem dos Hautes Alpes.
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For example, the mynavy is simply a rehashed version of A800 that you can buy from China retail shops (walk into a electronic centre) and you can see they sell it for about RM$400. If you can buy it from a Chinese shop, hnow much do you think you can buy at OEM volume? Proton is selling it for over $1,000. How much "pocket change" are they keeping? The maps that can originally be bought from TeleAtlas (very big mapping company) is under RM$50. The current maps powered by Mynavi is by TM. A GPs navigator is a fun system to use, assuming the map is good (which mynavi does not). You still need to provide additional services for a sophisticated consumer, includes ...
Int. J. Softw. Tools Technol. Transf., 18 (6), 581-586. Neveling K, Mensenkamp AR, Derks R, Kwint M, Ouchene H, Steehouwer M, van Lier B, Bosgoed E, Rikken A, Tychon M, Zafeiropoulou D, Castelein S, Hehir-Kwa J, Tjwan Thung D, Hofste T, Lelieveld SH, Bertens SM, Adan IB, Eijkelenboom A, Tops BB, Yntema H, Stokowy T, Knappskog PM, Høberg-Vetti H, Steen VM et al. (2016 ...
AP1_KLULA (P56095 ), ARGC_CHRVO (Q7NRT5 ), BAH_RHOER (Q8RSQ2 ), BTUB_PHOLL (Q7MYE3 ), CBID_PROMP (Q7V3N8 ), CHS1_CRYNH (O13356 ), CLS2_STAAC (Q5HEB2 ), CLS2_STAAR (Q6GEY7 ), CLS_STAAM (P63800 ), CLS_STAAN (P63801 ), CLS_STAAS (Q6G7M2 ), CLS_STAAW (P63802 ), COBT_DEIRA (Q9RYR8 ), DCL4_ORYSJ (A7LFZ6 ), DMXL1_HUMAN (Q9Y485 ), DMXL1_MOUSE (Q6PNC0 ), DNAG_NEIMA (P57028 ), DNAG_NEIMB (P57029 ), DNLJ1_STRGG (B1VUC2 ), DNLJ_FERNB (A7HJG6 ), DRD1_CARAU (P35406 ), EXOC1_DICDI (Q54NV1 ), FIXJ_AZOC5 (P26487 ), FLII_BUCBP (Q89AZ7 ), FMT_GEOSL (Q74GW4 ), FOLD2_ACIAD (Q6F8N7 ), FOLD_ACIBT (A3M846 ), FOLD_CALS4 (Q8RAD0 ), FOLD_MYCPE (Q8EV80 ), FOLD_PSYA2 (Q4FTX6 ), FOLD_PSYCK (Q1QD30 ), FOLD_RUTMC (A1AXA0 ), GLUQ_PROAC (Q6A7Y1 ), GLYA_MYCS2 (A0R2V7 ), GLYA_PROAC (Q6AAU3 ), GUAAB_PICTO (Q6L1Q1 ), GUAA_ASPOR (Q2UFN0 ), HEM1_RHORT (Q2RWE2 ), HIS5_ECOL6 (P60596 ), HIS5_ECOLI (P60595 ), HIS5_SHIBS (Q323I9 ), HIS5_SHIDS (Q32EF2 ), HIS5_SHIFL (Q83KJ5 ), HIS5_SHISS (Q3Z0G2 ), HLYE_ECO57 (Q9REB3 ), HLYE_ECOLI (P77335 ), ...
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BACKGROUND: Q fever is caused by the intracellular bacterium Coxiella burnetii. Initial infection can present as acute Q fever, while a minority of infected individuals develops chronic Q fever endocarditis or vascular infection months to years after initial infection. Serology is an important diagnostic tool for both acute and chronic Q fever. However, since immunosuppressive drugs may hamper the humoral immune response, diagnosis of Q fever might be blurred when these drugs are used. CASE PRESENTATION: A 71-year-old Caucasian male was diagnosed with symptomatic acute Q fever (based on positive C. burnetii PCR followed by seroconversion) while using anti-tumor necrosis factor-alpha (anti-TNFalpha) drugs for rheumatoid arthritis (RA). He was treated for two weeks with moxifloxacin. After 24 months of follow-up, the diagnosis of probable chronic Q fever was established based on increasing anti-C. burnetii phase I IgG antibody titres in a immunocompromised patient combined with clinical suspicion ...
The first case of Q fever in Taiwan was reported in 1993. The disease is considered to be emerging in Taiwan, but the route of transmission has remained unclear. The annual number of confirmed Q fever cases has been increasing up to more than 100 cases since 2005, comparing with less than 30 before 2003. The purpose of this study was to determine the seroprevalence and risk factors of Coxiella burnetii infection in veterinary-associated populations in southern Taiwan. A total of 228 serum samples of high risk individuals engaging in veterinary-related work or animal-farm work, were collected between March and June in 2007. The study individuals were interviewed by a structured questionnaire designed for Q fever investigation. Serum samples from different animal species were also obtained for Q fever analysis in the same study areas. Serological test was conducted by indirect immunofluorescence antibody assay (IFA). The result demonstrated the overall seroprevalence of Q fever was 26.3% in ...
Q fever bacteria (Coxiella burnetii, yellow), coloured transmission electron micrograph (TEM). Q fever is a rare livestock disease that can be spread to humans through inhalation of contaminated particles. It is considered the worlds most infectious disease, as just one bacterium is capable of causing infection. It causes flu-like symptoms including fever, headache and nausea. It can also lead to hepatitis, pneumonia or inflammation of the heart lining, all of which can be fatal. Magnification: x900 when printed 10 centimetres wide. - Stock Image C002/5597
Q fever, a rickettsial infection caused by Coxiella burnetii, has been recognized as a widely distributed zoonosis with the potential for causing both sporadic and epidemic disease. The resistance of Coxiella burnetii to heat, chemical agents, and desiccation allows the agent to survive for extended periods outside the host.. The infection is spread by the inhalation of infected material, mainly from sheep and goats. They shed the organism in feces, milk, nasal discharge, placental tissue, and amniotic fluid.. The clinical spectrum of disease ranges from unapparent to fatal. Respiratory manifestations usually predominate; endocarditis and hepatitis can be complications.. During the course of the infection, the outer membrane of the organism undergoes changes in its lipopolysaccharide structure, called phase variation. Differences in phase I and phase II antigen presentation can help determine if the infection is acute or chronic:. -In acute Q fever, the phase II antibody is usually higher than ...
To increase understanding of human bacterial and parasitic pathogens in bats, we investigated the prevalence of Babesia spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii in bats from China. Bats were captured from Mengyin County, Shandong Province of China using nets. DNA was extracted from the blood and spleen of bats for molecular detection of Babesia spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii with specific primers for each species. A total of 146 spleen samples and 107 blood samples of insectivorous bats, which belonged to 6 species within two families, were collected from Mengyin County, Shandong Province of China. We found that two Eptesicus serotinus (2/15, 13.3%) were positive for Babesia vesperuginis. We were unable to detect genomic sequences for Rickettsia spp., Anaplasma spp. and Coxiella burnetii. To our knowledge, our study showed for the first time the presence of Babesia vesperuginis in Eptesicus serotinus collected from China, suggesting that Babesia
For the detection and semi-quantitation of IgM antibodies to Coxiella burnetii, the etiologic agent of Q fever in human serum. Slide wells have individual spots of C. burnetii phase I and C. burnetii phase II in each well.. ...