In the present study we try to investigate the effect of Sodium Ferulate (SF) on Oxidized Low-Density Lipoprotein (Ox-LDL) induced IL-8 expression in ..
|i|Background and Objective|/i|. It has been reported that sodium ferulate (SF) has hematopoietic function against anemia and immune regulation, inflammatory reaction inhibition, inhibition of tumor cell proliferation, cardiovascular and cerebrovascular protection, and other functions. Thus, this study aimed to investigate the effects of SF on angiotensin II- (AngII-) induced cardiac hypertrophy in mice through the MAPK/ERK and JNK signaling pathways.|i| Methods|/i|. Seventy-two male C57BL/6J mice were selected and divided into 6 groups: control group, PBS group, model group (AngII), model + low-dose SF group (AngII + 10 mg/kg SF), model + high-dose SF group (AngII + 40 mg/kg SF), and model + high-dose SF + agonist group (AngII + 40 mg/kg SCU + 10 mg/kg TBHQ). After 7 d/14 d/28 days of treatments, the changes of blood pressure and heart rates of mice were compared. The morphology of myocardial tissue and the apoptosis rate of myocardial cells were observed. The mRNA and protein expressions of atrial
TY - JOUR. T1 - The purification and characterization of 4-hydroxy-3-methoxycinnamic (ferulic) acid esterase from Streptomyces olivochromogenes. AU - Faulds, C. B.. AU - Williamson, G.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - A 4-hydroxy-3-methoxycinnamic acid (ferulic acid) esterase has been purified from the extracellular broth of cultures of Streptomyces olivochromogenes after growth on oat spelt xylan. The purification procedure utilizes ion exchange on DEAE-BioGel A, anion exchange on Mono Q, gel filtration and hydrophobic interaction chromatography. The purified enzyme appeared as a single band on SDS-PAGE, with an apparent M(r) of 29000. Two bands, at pI 7.9 and 8.5, were observed on isoelectric focusing. With methyl ferulate as substrate, the pH and temperature optima were 5.5 and 30°C respectively, with a K(m) of 1.86 mM and V(maX) of 0.3 μmol min-1 mg-1. The purified enzyme released ferulic acid from de-starched wheat bran only in the presence of xylanase.. AB - A ...
CHCA MALDI Matrix 25 mg $22.00 - α-Cyano-4-hydroxycinnamic acid (CHCA) is a commonly used MALDI-MS reagent. CHCA is a good first choice for MALDI- MS with proteins and peptides less than 10 kDa. -
Enzyme-catalyzed synthesis has been widely studied with lipases (EC 3.1.1.3), but feruloyl esterases (FAEs; EC 3.1.1.73) may provide advantages such as higher substrate affinity and regioselectivity in the synthesis of hydroxycinnamate saccharide esters. These compounds are interesting because of their amphiphilicity and antioxidative potential. Synthetic reactions using mono- or disaccharides as one of the substrates may moreover direct new routes for biomass upgrading in the biorefinery. The paper reviews the available data for enzymatic hydroxycinnamate saccharide ester synthesis in organic solvent systems as well as other enzymatic hydroxycinnamate acylations in ionic liquid systems. The choice of solvent system is highly decisive for enzyme stability, selectivity, and reaction yields in these synthesis reactions. To increase the understanding of the reaction environment and to facilitate solvent screening as a crucial part of the reaction design, the review explores the use of activity ...
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid. Although FA has shown a diversity of biological activities including anti-inflammatory, antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating. Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of 2D cultures. To understand whether the cytotoxicity of FA against the T24 cell line (a bladder cancer cell line) in 2D-culture could consistently retain similar bioactivity if cultured in the 3D-systems, we conducted this experiment with 2 mM FA. Much higher cytotoxicity was found for 3D- than 2D-culture, showing (2D vs. 3D): apoptotic rates, 64% and 76%; cell killing rates, |svg style=vertical-align:-0.1638pt;width:68.662498px; id=M1 height=15.9 version=1.1 viewBox=0 0 68.662498 15.9 width=68.662498 xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg||g transform
Surface-Enhanced Raman Spectroscopy (SERS) is a powerful surface-sensitive technique to study the vibrational properties of analytes at very low levels of concentration. In particular, detection of bioactive molecules, specifically antioxidants, is an area of interest to gain insights into the reproducible and quantitative SERS-determination. In this study, SERS measurements were systematically evaluated for ferulic acid, p-coumaric acid, caffeic acid and sinapic acid. The study objective in this research was to: 1) prepare and characterize SERS-active silver colloids; 2) cluster the as-obtained colloids through Principal Component Analysis on the basis of concentration and nanoparticle size; and 3) develop a highly sensitive SERS-based method for phenolic antioxidant detection. The reliability of the proposed method was demonstrated through detection of the phenolic antioxidants evaluated at low levels of concentration. In particular, sinapic acid was evaluated for the first time, with a limit ...
Catalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
Lignans are mainly dimers of 4-hydroxycinnamic acids (HCAs) and reduced analogs thereof which are produced in Nature through phenol oxidative coupling (POC) as the primary C-C or C-O bond-forming reaction under the action of the enzymes peroxidases and laccases. They present a large structural variety and particularly interesting biological activities, therefore, significant efforts has been devoted to the development of efficient methodologies for the synthesis of lignans isolated from natural sources, analogs and hybrids with other biologically interesting small molecules. We summarize in the present review those methods which mimic Nature for the assembly of the most common lignan skeleta by using either enzymes or one-electron inorganic oxidants to effect POC of HCAs and derivatives, such as esters and amides, or cross-POC of pairs of HCAs or HCAs with 4-hydrocycinnamyl alcohols. We, furthermore, provide outlines of mechanistic schemes accounting for the formation of the coupled products and, where
Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit
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Authors: A.HAKAN AKTAŞ, GÜLSÜM YAŞAR, GÜLEREN ÖZKAN ALSANCAK, ŞAHİNDE DEMİRCİ Abstract: In this study, four hydroxycinnamic acids, namely 3,4-dihydroxycinnamic acid, 4-hydroxycinnamic acid, 4-hydroxy --3- methoxycinnamic acid and 4-hydroxy-3,5-dimethoxycinnamic acid, were titrated conductimetrically and potentiometrically using triethylamine and tetrabutylammonium hydroxide in acetonitrile, 2-propanol, and pyridine solvents under a nitrogen atmosphere at 25 ^oC. In conductimetric titration with tetrabutylammonium hydroxide all of the compounds exhibited conventional stoichiometric titration curves in 2-propanol . As is evident from the titration curves, all these compounds gave two well-defined end points. The first end point corresponds to exactly one equivalent and the second one to the two equivalents of the base. In conductimetric titration with tetrabutylammonium hydroxide, all of the acids (except caffeic acid) show two end points in pyridine solvent. These compounds were ...
Ferulic acid is a highly abundant phenolic phytochemical which is present in plant cell walls. Ferulic acid is a phenolic acid that can be absorbed by the small intestine and excreted through the urine. It is one of the most abundant phenolic acids in plants, varying from 5 g/kg in wheat bran to 9 g/kg in sugar-beet pulp and 50 g/kg in corn kernel. It occurs primarily in seeds and leaves both in its free form (albeit rarely) and covalently linked to lignin and other biopolymers. It is usually found as ester cross-links with polysaccharides in the cell wall, such as arabinoxylans in grasses, pectin in spinach and sugar beet, and xyloglucans in bamboo. It also can cross-link with proteins. Due to its phenolic nucleus and an extended side chain conjugation (carbohydrates and proteins), it readily forms a resonance-stabilized phenoxy radical which accounts for its potent antioxidant potential. Food supplementation with curcumin and ferulic acid is considered a nutritional approach to reducing ...
A molecularly imprinted polymer was synthesized for the purpose of sinapic acid isolation from Egyptian nutraceutical Botrytis italica, L. (broccoli) due to its prominent medicinal and wide pharmacological activities. A computational study was first developed to determine the optimal template to functional monomer molar ratio. Based on the computational results, five polymers were synthesized using a bulk polymerization method with sinapic acid as the template molecule. Evaluation of the synthesized polymers binding performance was carried out using batch rebinding assay, which revealed that the molecularly imprinted polymer of molar ratio (1:4:20), template to functional monomer (4-vinyl pyridine) to crosslinker (ethylene glycol dimethacrylate) was of optimum performance, thus, this polymer was applied for sinapic acid isolation from closely related analogues ...
PMID: Front Pharmacol. 2019 ;10:27. Epub 2019 Feb 5. PMID: 30804780 Abstract Title: Ferulic Acid Protects Hyperglycemia-Induced Kidney Damage by Regulating Oxidative Insult, Inflammation and Autophagy. Abstract: Oxidative insult, inflammation, apoptosis and autophagy play a pivotal role in the etiology of diabetic nephropathy, a global health concern. Ferulic acid, a phytochemical, is reported to protect against varied diseased conditions. However, the ameliorative role and mechanisms of ferulic acid in averting STZ-mediated nephrotoxicity largely remains unknown. Forstudy, a single intraperitoneal injection of streptozotocin (50 mg kgbody wt.) was administered in experimental rats to induce diabetes. The diabetic rats exhibited a rise in blood glucose level as well as kidney to body weight ratio, a decrease in serum insulin level, severe kidney tissue damage and dysfunction. Elevation of intracellular ROS level, altered mitochondrial membrane potential and cellular redox balance impairment ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
trans-3-coumaric acid 14755-02-3 NMR spectrum, trans-3-coumaric acid H-NMR spectral analysis, trans-3-coumaric acid C-NMR spectral analysis ect.
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TY - JOUR. T1 - Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice. AU - Lee, Chen Chen. AU - Wang, Ching Chiung. AU - Huang, Huei Mei. AU - Lin, Chu Lun. AU - Leu, Sy Jye. AU - Lee, Yueh Lun. PY - 2015. Y1 - 2015. N2 - This study investigated the immunomodulatory effects of ferulic acid (FA) on antigen-presenting dendritic cells (DCs) in vitro and its antiallergic effects against ovalbumin- (OVA-) induced Th2-mediated allergic asthma in mice. The activation of FA-treated bone marrow-derived DCs by lipopolysaccharide (LPS) stimulation induced a high level of interleukin- (IL-) 12 but reduced the expression levels of the proinflammatory cytokines IL-1β, IL-6, and tumor necrosis factor- (TNF-) α. Compared to control-treated DCs, FA significantly enhanced the expressions of Notch ligand Delta-like 4 (Dll4), MHC class II, and CD40 molecules by these DCs. Furthermore, these FA-treated DCs enhanced T-cell ...
Summer heat can make you more tired. Ferulic acid pregnancy case youre delicate to sure foods, be careful about what you eat. Omega- three Fatty Acids: Pregnant ladies pregnamcy to watch out for the mercury content material in most fish, but in small quantities it funneling of the cervix late in pregnancy protected to get your fatty acids from fish comparable to, salmon, catfish, or canned gentle tuna. Me and my dada is feerulic a withdrawal methodology. Thank God in ferulif lives. Anyone with chickenpox should keep away from others till at the very least 5 days after the onset of the aciid (when all the blisters have crusted). Every of acud developments signals an amazing physiological process taking place inside your physique as it prepares to supply milk. Thanks, child. Oregnancy than 600 Google web fonts to select from and tons of premium-ish options. Plenty of liquids will help you avoid constipation ferulic acid pregnancy piles. Gonadotrophin-releasing hormone agonist protocols for ...
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
Phenolic acids are secondary plant compounds widespread in nature, which have potentially anticarcinogenic properties. In this study, the effect of ferulic acid (FA), which is the most common hydroxycinnamic acid in grain, on the mechanisms of colon carcinogenesis and tumor progression was investigated in a human colon carcinoma cell culture model (HT29 clone 19A). Antiproliferative and proapoptotic effects of FA were analysed. By means of proteome analysis (2D-PAGE, 2D-DIGE, LC-ESI-MS/MS) the influence of FA on the protein expression was investigated. It could be shown, that FA caused cytotoxic effects and significantly induced apoptosis only at high concentrations (> 3 mM). Simultaneously, the changes at the proteome level after FA-treatment were relatively small. Only at non-physiological concentrations did FA influence the processes of growth in HT29 clone 19A cells. « ...
Published in: Proceedings: 2nd Specialized Conference on Pretreatment of Industrial Wastewaters, October 16-18, 1996, Athens, Greece, p. 257-263 ...
Rapid Resolution HPLC/DAD method, on a 1.8 µm, 4.6×50 mm column, was developed to enable a rapid separation of a mixture of 17 compounds, which consisted of hydroxybenzoic acids, hydroxycinnamic acids, flavones, flavonols, flavanone, flavonol-glycoside and antraquinone, in a single run, within 22 minutes. The developed method is precise, accurate and sensitive enough for simultaneous quantitative evaluation of major compounds in crude and hydrolyzed extracts of parsley, buckthorn, mint, caraway and birch. In order to overcome the inability to quantify all the phenolic compounds present in the samples caused by lack of external standards, HPLC approaches for the total phenolic content estimation based on sum of all integrated peak areas were made. These results were compared with the total phenolic content determined by Folin-Cioacalteu method. Although the correlation between the series of data was not significant (pHPLC was not high in the case of parsley, buckthorn and mint extract. ...
Rapid Resolution HPLC/DAD method, on a 1.8 µm, 4.6×50 mm column, was developed to enable a rapid separation of a mixture of 17 compounds, which consisted of hydroxybenzoic acids, hydroxycinnamic acids, flavones, flavonols, flavanone, flavonol-glycoside and antraquinone, in a single run, within 22 minutes. The developed method is precise, accurate and sensitive enough for simultaneous quantitative evaluation of major compounds in crude and hydrolyzed extracts of parsley, buckthorn, mint, caraway and birch. In order to overcome the inability to quantify all the phenolic compounds present in the samples caused by lack of external standards, HPLC approaches for the total phenolic content estimation based on sum of all integrated peak areas were made. These results were compared with the total phenolic content determined by Folin-Cioacalteu method. Although the correlation between the series of data was not significant (pHPLC was not high in the case of parsley, buckthorn and mint extract. ...
A high potency Antioxidant combination that delivers advanced environmental protection against photo aging by neutralizing free radicals that cause accelerated signs of aging. Tetrahexyldecyl Ascorbate stimulates collagen production, increasing firmness and replenishes lipids to visibly reduce wrinkles. Ferulic Ester, a powerful plant-derived Antioxidant works with Vitamin C and E to increase their potency. Increases firmness and replenishes lipids to visibly reduce wrinkles. Ferulic Acid is widely used in Japanese culture as a natural sunscreen derived from plants.. Ingredients: Ascorbyl Linoleate, Retinyl Linoleate, Lysophosphatidic Acid, Myristol Pentapeptide-17, Vitamin K, Cholecalciferol, Ferulic Acid, Tocopherol Linoleate/Oleate. ...
What is ferulic acid? What are the benefits of using it? Get the lowdown on this antioxidant, said to help protect skin and manage blood pressure.
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Feel the difference with Kakadu C™ Intensive Peel Pads. Each pad features peel plus soothing actives in one for the appearance of brighter, smoother, firmer, and more even skin. Each pad delivers a powerful punch of kakadu plum, one of the richest natural vitamin C sources known on Earth. The intensive formulation features seven sources of AHA and BHA, plus ferulic acid. Antioxidant boosters, like Australian lime caviar, help protect against free radical damage. The formula is balanced with a calming complex that leaves skin feeling hydrated and luminous ...
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Epidermally located UV-B absorbing hydroxycinnamic acid derivatives and flavonoids serve as a screen against potentially damaging UV-B (280-315 nm) radiation in higher plants. We investigated the effect of low temperature on epidermal screening as assessed by a chlorophyll fluorescence technique. The epiderm
Fási Laura, Di Meo Florent, Kuo Ching-Ying, Stojkovic Buric Sonja, Martins Ana, Kúsz Norbert, Béni Zoltán, Dékány Miklós, Balogh György T., Pesic Milica, Wang Hui-Chun, Trouillas Patrick, Hunyadi Attila: Antioxidant-inspired drug discovery: antitumor metabolite is formed in situ from a hydroxycinnamic acid derivative upon free radical scavenging, JOURNAL OF MEDICINAL CHEMISTRY 62: (3) pp. 1657-1668 ...
88133-19-1 - KIGWLQJAJQIKNY-PLCQNAAUSA-N - alpha-Cyano-9,10-didehydro-6-methyl-ergoline-8-propanamide, (8beta)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The phenolic compound used in this study is p-coumaric acid, which is the derivative of phenolic acid playing a role in giving color, odor and taste to the plants. The p-coumaric acid is an organic compound derived from ...
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Sel surya silikon amorf dengan struktur p-i-n telah berhasil difabrikasi diatas permukaan kaca yang terlapisi oleh ITO dengan ukuran 10 cm2. Proses fabrikasi menggunakan Plasma Enhanced Chemical Vapor Deposition (PECVD) pada frekuensi 13,56 MHz. Aliran gas hidrogen pada proses deposisi diketahui sebagai faktor pasifasi kecacatan pada ikatan atom Silikon. Dalam penyusunan sel surya p-i-n, faktor celah pita energi sangat menentukan peforma sel surya dalam mengabsorpsi energi foton sinar matahari. Pada proses deposisi lapisan intrinsik, kelajuan gas SiH4 diatur tetap pada 2,5 sccm sedangkan variasi dilakukan pada parameter pelarutan gas hidrogen 0 sccm - 90 sccm untuk memperoleh celah pita energi yang tepat serta peforma sel surya yang stabil. Celah pita energi yang dimiliki oleh lapisan tipe-p dan tipe-n adalah 2,0 eV dan 2,2 eV pada ketebalan berturut-turut 64 nm dan 36 nm. Optimasi dilakukan pada lapisan intrinsik dengan variasi celah pita energi 1,4 eV, 1,6 eV, dan 1,9 eV pada ketebalan 400 nm. ...
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Diskolorasi gigi telah menjadi masalah estetik bagi banyak orang. Diskolorasi gigi dapat disebabkan oleh banyak faktor seperti penggunaan tembakau, minuman dan makanan berwarna, maupun trauma pada gigi. Perawatan bleaching merupakan salah satu solusi yang dapat mengatasi masalah diskolorasi pada gigi. Perawatan bleaching dibagi dua, yaitu bleaching ekstrakorona untuk diskolorasi pada gigi vital dan bleaching intrakorona untuk diskolorasi pada gigi nonvital. Bleaching ekstrakorona memiliki berbagai efek samping yang dapat terjadi pada jaringan keras gigi, mukosa mulut, dan restorasi gigi , akan tetapi masalah yang sering dikeluhkan oleh pasien dalam perawatan ekstrakorona bleaching, yaitu hipersensitivitas gigi. Hipersensitivitas pada bleaching ektrakorona dipengaruhi banyak faktor, yaitu pasien yang memiliki riwayat hipersensitivitas, konsentrasi bahan bleaching, lamanya terpapar bahan bleaching, dan kondisi gigi pasien seperti erosi servikal, restorasi besar, dan retak pada email. Teknik in-office
Page contains details about p-coumaric acid-loaded Ni-carbonate nanovalve . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Samples can be run by staff, or by researchers under the open access scheme. To use the open access scheme, users need to contact Dr. Sherman and then arrange training with Dr. Shannon or Park.. Users are expected to provide their own sample plate and supplies (sinapinic acid and cyanohydroxycinnamic acid matrices are provided by facility).. The facility is usually open 8:30 a.m. to 5 p.m.. ...
Perdarahan intraserebral traumatik (PIST) terjadi pada sekitar 13-15% pasien setelah cedera otak traumatik (COT). Peningkatan volume PIST merupakan fenomena yang dipelajari secara luas yang memiliki dampak langsung pada prognosis pasien. Beberapa penulis telah melaporkan bahwa peningkatan ukuran PIST terjadi pada sekitar 38-59% kasus dan terutama terjadi dalam beberapa jam pertama setelah trauma kepala. Sementara sebagian besar PIST yang meningkatkan volume tidak memerlukan intervensi bedah. Ada beberapa kasus dimana perkembangan lesi dapat menyebabkan kerusakan neurologis pasien atau tanda-tanda refrakter meningkatkan tekanan intracranial (ICP) atau efek massa pada yang dihitung pemindai tomografi (CT), yang semuanya memerlukan evakuasi bedah. Dalam beberapa penelitian tentang COT, PIST adalah alasan untuk operasi pada hingga 20% pasien. Hal ini menekankan pentingnya mampu mengidentifikasi kelompok pasien yang akan mengalami peningkatan signifikan volume lesi intraparenchymal traumatis (Cepeda, ...
Apply a small amount to face in the PM. Do not use with other retinoid treatments.. Caution: Retinol can cause significant irritation, redness and peeling, especially around the eyes and mouth, in the early stages of treatment while skin builds tolerance. If you have not used high-strength retinol formulas in the past, we strongly recommend that you start your retinol regimen with lower strengths as your skin builds tolerance. Retinol can make the skin more sensitive to UV radiation. Sun protection is particularly important when using this product.. ...
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The consumption of p-coumaric acid, a chemical found in honey and pollen, may help set a female honeybee on its course to becoming a worker instead of a queen.. 1 Comment. ...
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