Healthcare settings can amplify transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), but knowledge gaps about the epidemiology of transmission remain. We conducted a retrospective cohort study among healthcare personnel in hospital units that treated MERS-CoV patients. Participants were interviewed about exposures to MERS-CoV patients, use of personal protective equipment, and signs and symptoms of illness after exposure. Infection status was determined by the presence of antibodies against MERS-CoV. To assess risk factors, we compared infected and uninfected participants. Healthcare personnel caring for MERS-CoV patients were at high risk for infection, but infection most often resulted in a relatively mild illness that might be unrecognized. In the healthcare personnel cohort reported here, infections occurred exclusively among those who had close contact with MERS-CoV patients.

Author affiliations: King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia (B.M. Alraddadi, H.S. Al-Salmi, H.H. Al-Turkistani, S.S. Al-Rehily, H.A. Alserehi, G.Y. Wali, A.N. Alshukairi); Ministry of Health, Jeddah (B.M. Alraddadi, E.I. Azhar, T.A. Madani); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (K. Jacobs-Slifka, R.B. Slayton, C.F. Estivariz, A.I. Geller, L. Haynes, D.L. Swerdlow, J.A. Jernigan); King Abdulaziz University, Jeddah (E.I. Azhar, T.A. Madani) ...

Background: Patients with suspected Middle East respiratory syndrome coronavirus (MERS-CoV) infection should be hospitalized in isolation wards to avoid transmission. This suspicion can also lead to medical confusion and inappropriate management of acute respiratory syndrome due to causes other than MERS-CoV. Methods: We studied the characteristics and outcome of patients hospitalized for suspected MERS-CoV infection in the isolation wards of two referral infectious disease departments in the Paris area between January 2013 and December 2016. Results: Of 93 adult patients (49 male (52.6%), median age 63.4 years) hospitalized, 82 out of 93 adult patients had returned from Saudi Arabia, and 74 of them were pilgrims (Hajj). Chest X-ray findings were abnormal in 72 (77%) patients. The 93 patients were negative for MERS-CoV RT-PCR, and 70 (75.2%) patients had documented infection, 47 (50.5%) viral, 22 (23.6%) bacterial and one Plasmodium falciparum malaria. Microbiological analysis identified Rhinovirus (27

Detection of human cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection internationally is a global public health concern. Rigorous risk assessment is particularly challenging in a context where surveillance may be subject to under-ascertainment and a selection bias towards more severe cases. We would like to assess whether the virus is capable of causing widespread human epidemics, and whether self-sustaining transmission is already under way. Here we review possible transmission scenarios for MERS-CoV and their implications for risk assessment and control. We discuss how existing data, future investigations and analyses may help in reducing uncertainty and refining the public health risk assessment and present analytical approaches that allow robust assessment of epidemiological characteristics, even from partial and biased surveillance data. Finally, we urge that adequate data be collected on future cases to permit rigorous assessment of the transmission characteristics and

Between 12 and 16 October 2014, the National IHR Focal Point for the Kingdom of Saudi Arabia (KSA) notified WHO of 5 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection, including 2 deaths.

In 2012, the first cases of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) were identified. Since then, more than 1,000 cases of MERS-CoV infection have been confirmed; infection is typically associated with considerable morbidity and, in approximately 30% of cases, mortality. Currently, there is no protective vaccine available. Replication-competent recombinant measles virus (MV) expressing foreign antigens constitutes a promising tool to induce protective immunity against corresponding pathogens. Therefore, we generated MVs expressing the spike glycoprotein of MERS-CoV in its full-length (MERS-S) or a truncated, soluble variant of MERS-S (MERS-solS). The genes encoding MERS-S and MERS-solS were cloned into the vaccine strain MVvac2 genome, and the respective viruses were rescued (MVvac2-CoV-S and MVvac2-CoV-solS). These recombinant MVs were amplified and characterized at passages 3 and 10. The replication of MVvac2-CoV-S in Vero cells turned out to be comparable to ...

Between 13 and 14 March 2016, the National IHR Focal Point for the Kingdom of Saudi Arabia notified WHO of 4 additional cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection. One of these reported cases is linked to the MERS-CoV outbreak currently occurring in a hospital in Buraidah city.

Since its first emergence in 2012, cases of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) have continued to occur. In this study, we present two nucleic acid visualization assays that target the MERS-CoV UpE and N genes as a p

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic ...

Middle East respiratory syndrome coronavirus From Wikipedia, the free encyclopedia (Redirected from Middle east respiratory syndrome coronavirus) This article is about the virus. For the disease, see Middle East respiratory syndrome. For the outbreak, see 2012 Middle East respiratory syndrome coronavirus outbreak. For general about the virus, see Coronavirus. MERS-CoV MERS-CoV particles…

During the summer of 2012, in Jeddah, Saudi Arabia, a hitherto unknown coronavirus (CoV) was isolated from the sputum of a patient with acute pneumonia and renal failure (1, 2). The isolate was provisionally called human coronavirus Erasmus Medical Center (EMC) (3). Shortly thereafter, in September 2012, the same type of virus, named human coronavirus England 1, was recovered from a patient with severe respiratory illness who had been transferred from the Gulf region of the Middle East to London, United Kingdom (4) (GenBank accession no. KC164505.2). The onset of the new disease was traced back to an even earlier time point. Already in April 2012, a cluster of pneumonia cases in health care workers had occurred in an intensive care unit of a hospital in Zarqa, Jordan (5). Two persons died, both of whom were confirmed to have been infected with the novel coronavirus through a retrospective analysis of stored samples (6). These findings met with considerable concern. Although the number of ...

TY - JOUR. T1 - Extensive Viable Middle East Respiratory Syndrome (MERS) Coronavirus Contamination in Air and Surrounding Environment in MERS Isolation Wards. AU - Kim, Sung Han. AU - Chang, So Young. AU - Sung, Minki. AU - Park, Ji Hoon. AU - Kim, Hong Bin. AU - Lee, Heeyoung. AU - Choi, Jae Phil. AU - Choi, Won Suk. AU - Min, Ji Young. N1 - Funding Information: Financial support. This work was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health &Welfare, Republic of Korea (grant number HI15C2774). This work was also supported by the National Research Foundation of Korea (NRF grant number 2014K1A4A7A01074646) funded by the Korea government and by the Gyeonggi Institute of Science & Technology Promotion Middle East respiratory syndrome grant funded by Gyeonggi-do. Publisher Copyright: © 2016 The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. ...

Coronaviruses are common viruses that can affect humans and animals. Coronaviruses are medium-sized enveloped positive-stranded RNA viruses whose name comes from their characteristic crown-like appearance in electron micrographs. Coronaviruses are widespread among birds and mammals, with bats being the largest host of various genotypes1. Human coronaviruses were first identified in the mid-1960s2. There are two genera of human coronaviruses: alpha coronaviruses and beta coronaviruses. The Middle East respiratory syndrome coronavirus/MERS-CoV, and severe acute respiratory syndrome coronavirus/SARS-CoV are examples of beta coronaviruses. Human coronaviruses probably account for 5 to 10 percent of all acute upper respiratory tract infections in adults1.. Seasonally, coronaviruses are ubiquitous. In temperate climates, coronavirus respiratory infections occur primarily in the winter although sometimes these infections can peak in the fall or spring1.. ...

The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory disease and systemic dysfunction that may eventually lead to the death of the patients. After MERS-CoV was first diagnosed in the South Korea, in May 2015, it affected 186 individuals and claimed 37 lives in short span of time (case fatality rate = 19.9%). Compared to MERS-CoV in the Middle East, MERS-CoV in South Korea appeared to be more transmissible, and induced multiple human-to-human transmission. These knowledge gaps caused the failure of early prevention, and disseminated MERS-CoV brought out a great loss of lives and economy. The MERS-CoV outbreak revealed the potential weakness of public health system in South Korea, and promoted the reestablishment of preventive strategies for imported infectious diseases. In these regards, we analyzed the potential for additional import of re-emerged and emerging infectious diseases, such as dengue fever, malaria, chikungunya fever and hepatitis A, from Africa ...

Clinicians, laboratories and public health practitioners should be aware that many Muslims from Australia will travel to Saudi Arabia in October to undertake the Hajj between 13 and 18 October, and may travel at other times to undertake the Umrah. Health professionals should be aware of the possibility of cases in travellers returning from the Hajj which ends on 18 October 2013.. The Saudi Ministry of Health recommends that elderly people and those with chronic diseases such as heart disease, kidney disease, respiratory disease and diabetes, as well as patients with congenital and acquired immune deficiency diseases, cancer patients, pregnant women and children, defer travel to Saudi Arabia for the Umrah and Hajj this year.. WHO advises that that pre-existing major medical conditions (e.g. chronic diseases such as diabetes or chronic bronchitis, immunodeficiency) can increase the likelihood of medical problems, including MERS-CoV infection, during travel; thus, pilgrims should consult their ...

TY - JOUR. T1 - Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. AU - Josset, Laurence. AU - Menachery, Vineet D.. AU - Gralinski, Lisa E.. AU - Agnihothram, Sudhakar. AU - Sova, Pavel. AU - Carter, Victoria S.. AU - Yount, Boyd L.. AU - Graham, Rachel L.. AU - Baric, Ralph S.. AU - Katzea, Michael G.. PY - 2013. Y1 - 2013. N2 - A novel human coronavirus (HCoV-EMC) was recently identified in the Middle East as the causative agent of a severe acute respiratory syndrome (SARS) resembling the illness caused by SARS coronavirus (SARS-CoV). Although derived from the CoV family, the two viruses are genetically distinct and do not use the same receptor. Here, we investigated whether HCoV-EMC and SARS-CoV induce similar or distinct host responses after infection of a human lung epithelial cell line. HCoV-EMC was able to replicate as efficiently as SARS-CoV in Calu-3 cells and similarly induced minimal ...

On 18 April 2014, the Ministry of Health in Greece reported one laboratory-confirmed case of infection with Middle East respiratory syndrome coronavirus (MERS-CoV). This is the first case of MERS-CoV infection in Greece.

Rapid-response platforms are needed to control newly emerging virus pathogens. MERS-CoV likely emerged in the Middle East from exotic animals, perhaps bats, although the exact timing and origins of this pathogen in human populations remains unclear and is under study. MERS-CoV has caused 54 deaths at the time of writing (∼50% mortality), including documented instances of human-to-human transmission (3, 8). Therefore, the epidemic potential of MERS-CoV is high and its biology, life cycle, gene function, and pathogenic mechanisms clearly warrant additional study.. Developing full-length infectious cDNAs of emerging RNA viruses is assisted by the availability of high-throughput sequencing, gene synthesis, and the use of class II/IIS restriction endonucleases that allow seamless assembly of consensus synthetic cDNA fragments into full-length infectious cDNAs. In this instance, we synthesized a molecular clone from the published sequence, assembled full-length genomes, and isolated recombinant ...

An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the

What are coronaviruses?. Coronaviruses are a large family of viruses that can infect humans or animals. Sometimes an animal coronavirus can change so that it can infect people and become a human coronavirus. There are seven known types of human coronaviruses. Four types (229E, NL63, OC43, and KHU1) are common and cause mild to moderate respiratory infections, like the common cold. Two types, Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome coronavirus (MERS-CoV), can cause severe respiratory infections. The seventh type (SARS-CoV-2) is the newest coronavirus. It first emerged in the Wuhan Province in China in December 2019. The infectious respiratory disease caused by this virus was named Coronavirus Disease 2019, or more commonly COVID-19.. Who gets coronavirus infections?. Most people become infected with coronaviruses that cause the common cold at some point during their lives. These infections often occur in the fall or winter.. The initial ...

WHO has issued Middle East respiratory syndrome coronavirus (MERS-CoV) - update. Excerpt: On 24 April 2014, the National IHR Focal Point (NFP) of Jordan reported a laboratory-confirmed case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection in a 28 year-old...

WHO has convened an Emergency Committee under the International Health Regulations (IHR) to advise the Director-General on the status of the current situation. The Emergency Committee, which comprises international experts from all WHO Regions, unanimously advised that, with the information now available, and using a risk-assessment approach, the conditions for a Public Health Emergency of International Concern (PHEIC) have not at present been met. ...

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Discussion. The novel coronavirus is a member of the β coronavirus type, with humans as the host. Since the first human coronavirus (HCoV) was isolated from the nasal secretions of patients with the common cold in 1965, six different strains of CoV are known to infect humans. These CoV strains include severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the common cold viruses in individuals with strong immunity (such as 229E, OC43, NL63, and HKU1).1 This novel coronavirus, COVID-19, has more than 85% homology with the previously detected bat coronavirus (a SARS-related coronavirus species, that is, SARS coronavirus). However, there are clear differences in the genetic characteristics of COVID-19 compared with SARS-CoV and MERS-CoV.5. Through observation of the current global epidemic situation, we can demonstrate the infectivity and pathogenicity of COVID-19. To the treatment of COVID-19, the main treatment is antiviral therapy, ...

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Viral respiratory system diseases such as for example severe acute respiratory system symptoms (SARS) and Middle East respiratory system symptoms (MERS) always pose a serious threat to the people. using the same sea food market. Together with the Spring Event exodus, an outbreak appeared unavoidable. This problem attracted the interest of the Chinese language Middle for Disease Control and Avoidance (CDC), who instantly released a crisis response. The World Health Organization (WHO) also responded promptly and declared the outbreak a public health emergency of international concern (PHEIC). The causative agent of the unidentified pneumonia has been confirmed as a novel coronavirus by sequencing and aetiological investigations by several independent laboratories in China. Following the isolation of the new coronavirus, it was found to be distinct both from Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) [1,2]. Coronaviruses are ...

Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based design to develop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal prefusion conformation and demonstrate that our engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV. We also determined high-resolution structures of the trimeric MERS-CoV S ectodomain in complex with G4, a stem-directed neutralizing antibody. The structures reveal that G4 recognizes a glycosylated loop that is variable among coronaviruses and they define four conformational states of the trimer wherein each receptor-binding domain is either ...

Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.

Middle East Respiratory Syndrome (MERS) is a viral respiratory illness. First reported in Saudi Arabia in 2012, it has since spread to the U.S.

Background Korea failed in its risk communication during the early stage of the Middle East Respiratory Syndrome (MERS) outbreak; consequently, it faced difficulties in managing MERS, while disease-related worry increased. Disease-related worry can help disease prevention and management, but can also have a detrimental effect. This study measured the overall level of disease-related worry during the MERS outbreak period in Korea and the influencing factors and levels of disease-related worry during key outbreak periods. Methods The cross-sectional survey included 1,000 adults who resided in Korea. An ordinal logistic regression was performed for the overall level of MERS-related worry, and influencing factors of worry were analyzed. A reliability test was performed on the levels of MERS-related worry during key outbreak periods. Results The overall level of MERS-related worry was 2.44. Multivariate analysis revealed that women and respondents w very poor subjective health status had higher levels of

1. Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N. Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis. BMC Public Health. 2016 Nov 29;16(1):1203.. 2. Dinh L, Chowell G, Mizumoto K, Nishiura H. Estimating the subcritical transmissibility of the Zika outbreak in the State of Florida, USA, 2016. Theor Biol Med Model. 2016 Nov 9;13(1):20.. 3. Nah K, Otsuki S, Chowell G, Nishiura H. Predicting the international spread of Middle East respiratory syndrome (MERS). BMC Infect Dis. 2016 Jul 22;16:356. doi: 10.1186/s12879-016-1675-z.. 4. Otsuki S, Nishiura H. Reduced Risk of Importing Ebola Virus Disease because of Travel Restrictions in 2014: A Retrospective Epidemiological Modeling Study. PLoS One. 2016 Sep 22;11(9):e0163418. doi: 10.1371/journal.pone.0163418.. 5. Nishiura H, Mizumoto K, Rock KS, Yasuda Y, Kinoshita R, Miyamatsu Y. A theoretical estimate of the risk of microcephaly during pregnancy with Zika virus infection. ...

A collaborative team from The University of Texas Medical Branch at Galveston, Saudi Arabia and Canada developed a potent and safe vaccine that protects against the deadly Middle East respiratory syndrome, or MERS.

Comments, concepts and statistics about Healthcare worker infected with Middle East respiratory syndrome during cardiopulmonary resuscitation in Korea, 2015.

Background Viral load kinetics and duration of viral shedding are important determinants for disease transmission. We aimed to characterise viral load dynamics, duration of viral RNA shedding, and viable virus shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in various body fluids, and to compare SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV) viral dynamics. Methods In this systematic review and meta-analysis, we searched databases, including MEDLINE, Embase, Europe PubMed Central, medRxiv, and bioRxiv, and the grey literature, for research articles published between Jan 1, 2003, and June 6, 2020. We included case series (with five or more participants), cohort studies, and randomised controlled trials that reported SARS-CoV-2, SARS-CoV, or MERS-CoV infection, and reported viral load kinetics, duration of viral shedding, or viable virus. Two authors independently extracted data from published studies, or contacted authors to request ...

The recently identified Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and fatal acute respiratory illness in humans. However, no prophylactic and therapeutic agents specifically against MERS-CoV are currently available. Entry of MERS-CoV into target cells depends on binding of the receptor binding domain (RBD) of the viral envelope spike glycoprotein to the cellular receptor dipeptidyl peptidase 4 (DPP4). We report the isolation and characterization of two potent human RBD-specific neutralizing monoclonal antibodies (MERS-4 and MERS-27) derived from single-chain variable region fragments of a nonimmune human antibody library. MERS-4 and MERS-27 inhibited infection of both pseudotyped and live MERS-CoV with IC50 (half-maximal inhibitory concentration) at nanomolar concentrations. MERS-4 also showed inhibitory activity against syncytia formation mediated by interaction between MERS-CoV spike glycoprotein and DPP4. Combination of MERS-4 and MERS-27 demonstrated a synergistic ...

Professor Paul Kellam of Imperial College London is an expert on the genetics of viruses. His team delivered the genome analysis that helped to tackle a previous coronavirus outbreak, the Middle East Respiratory Syndrome Coronavirus, known as Mers.. Each time a coronavirus moves from one person to the next, there is a slight genetic mutation, says Prof Kellam, allowing researchers to map its family tree.. So when a version of the virus is analysed from any new location, it is possible to see how it compares with samples from the original outbreak in Wuhan, or its relationship to other offshoots of the virus in other countries.. Researchers in Milan reported that the version of the coronavirus in Lombardy matched an outbreak in Germany, centred on a businessman from Munich who had met a woman from Shanghai carrying the virus.. This would mean that while the Italian authorities were closing the air routes from China, the virus could have already arrived from Germany.. There were questions about ...

MERS is caused by a virus called Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which belongs to the Coronavirus family of viruses. MERS Virus belongs to the genus Betacoronavirus. Coronavirus family of viruses includes viruses that usually cause respiratory tract illnesses like the common cold in human beings, and also, these viruses cause a number of diseases in animals. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) causes Severe Acute Respiratory Syndrome (SARS).. Continue reading → ...

The global novel coronavirus (COVID‐19 or 2019‐CoV) issue has posed significant threats to international human health and the economy, human are fighting this novel coronavirus together. Omega-3 polyunsaturated fatty acids and antiviral treatments should be useful in fighting novel coronavirus (COVID‐19).

We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with …

Dromedaries in Africa and elsewhere carry the Middle East respiratory syndrome coronavirus (MERS-CoV). To search for evidence of autochthonous MERS-CoV infection in humans, we tested archived serum from livestock handlers in Kenya for MERS-CoV antibodies. Serologic evidence of infection was confirmed for 2 persons sampled in 2013 and 2014 ...

The ECDC Communicable Disease Threats Report (CDTR) is a weekly bulletin for epidemiologists and health professionals on active public health threats. This issue covers the period from 4-10 November 2018 and includes updates on Middle East respiratory syndrome Middle East respiratory syndrome coronavirus (MERS-CoV), measles, influenza, influenza A(H5N6), West Nile virus, Ebola virus disease, dengue and malaria. ...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged to cause widespread infections in humans. SARS-CoV-2 infections have been reported in the Kingdom of Saudi Arabia, where Middle East respiratory syndrome coronavirus (MERS-CoV) causes seasonal outbreaks with a case fatality rate of ~37 %. Here we show that there exists a theoretical possibility of future recombination events between SARS-CoV-2 and MERS-CoV RNA. Through computational analyses, we have identified homologous genomic regions within the ORF1ab and S genes that could facilitate recombination, and have analysed co-expression patterns of the cellular receptors for SARS-CoV-2 and MERS-CoV, ACE2 and DPP4, respectively, to identify human anatomical sites that could facilitate co-infection. Furthermore, we have investigated the likely susceptibility of various animal species to MERS-CoV and SARS-CoV-2 infection by comparing known virus spike protein-receptor interacting residues. In conclusion, we suggest that a

Acknowledgment: The authors thank the members of the Department of Clinical Nursing and the Infection Prevention and Control Program, King Abdulaziz Medical City, Riyadh, Saudi Arabia, for their assistance. They also thank the following persons: From the King Saud bin Abdulaziz University for Health Sciences, Riyadh: Sameera Johani, MD, Division of Microbiology, Pathology & Laboratory Medicine; Abdullah Ghamdi, MD, Department of Cardiac Sciences; Ghassan A. Al-Ghamdi, MD, Intensive Care Department and Assistant Professor, College of Medicine; Saqib I. Dara, MD, Intensive Care Department; Raed A. Hijazi, MD, Emergency Medicine; Olivia A. Trinidad, RRT, Edgardo Tabhan, RRT, and Charina Olay, RRT, all Respiratory Therapist I, Respiratory Services. From the King Abdulaziz Hospital, Al-Ahsa: Yusri Taha, MD, and Mohammed Ayman El Gammal, MD, Infectious Diseases, Department of Medicine and Abdulsalam Al-Aithan, MD, Pulmonary & Intensive Care Medicine. From the Imam Abdulrahman Bin Faisal Hospital, ...

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Dr Shikha Sharma. Coronavirus disease (COVID-19) is an unforgettable word in 2020. World health organization has declared COVID-19 as pandemic and according to the Worldometer site, it has affected 212 countries and territories and has caused approximately 2.8 lakhs deaths so far. According to the various published scientific evidences COVID-19 is an infectious disease caused by new coronavirus that can lead to lung dysfunction. There are 7 coronaviruses that are known to cause disease in humans and among these 3 can cause the severe respiratory infection. These are severe acute respiratory syndrome coronavirus (SARS-CoV) identified in 2002 in China, Middle East respiratory syndrome coronavirus (MERS-CoV) identified in 2012 in Saudi Arabia and severe acute respiratory syndrome coronavirus2 (SARS-CoV2) commonly called COVID-19 identified in late 2019 in Wuhan, China. SARS-CoV, MERS-CoV and COVID-19 are closely related but COVID-19 spread more quickly than the other two. Over 8000 people from 29 ...

Human coronavirus NL63 or HCoV-NL63 is a species of coronavirus that was identified in late 2004 in a seven-month-old child with bronchiolitis in the Netherlands. Infection with the virus has been confirmed worldwide, and has an association with many common symptoms and diseases. Associated diseases include mild to moderate upper respiratory tract infections, severe lower respiratory tract infection, croup and bronchiolitis. The virus is found primarily in young children, the elderly, and immunocompromised patients with acute respiratory illness. It also has a seasonal association in temperate climates. A study performed in Amsterdam estimated the presence of HCoV-NL63 in approximately 4.7% of common respiratory illnesses. Further studies confirmed that the virus is not an emerging virus, but rather one that continually circulates the human population. The first cases of the infection with HCoV-NL63 were found in young children with severe lower respiratory tract infections admitted to ...

Acute respiratory tract infections in humans are responsible for significant morbidity and mortality especially in children, elderly, and the immunocompromised. Virus infection is the primary cause of acute respiratory tract infections. Infection with coronaviruses can cause disease ranging from common colds to severe acute respiratory syndrome. Currently no coronavirus-specific antivirals are available. Patients are given symptomatic treatment, or are prescribed inappropriately antibiotics which do not target the underlying virus infection. The identification of specific inhibitors of coronaviruses or knowledge about how coronaviruses interact with the innate immune system could provide new avenues for developing therapeutics. I investigated the replication of human coronavirus NL63 (HCoV-NL63) in primary human airway epithelial cultures and characterized the activity of the viral papain-like protease 2 (PLP2) domain. Using quantitative real time PCR and imaging techniques I showed that HCoV-NL63

ARTICLE:. J Dyall et al. Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection. Antimicrobial Agents and Chemotherapy DOI: 10.1128/AAC.03036-14 (2014).. WHO:. NIAID Director Anthony S. Fauci., M.D., is available to comment on this research. Co-author Lisa Hensley, Ph.D., associate director for science, NIAID Integrated Research Facility, is also available to discuss the findings.. CONTACT:. To schedule interviews, please contact Anne A. Oplinger, (301) 402-1663, [email protected].. For additional information about research on MERS and other coronaviruses by NIAID scientists and grantees, see: http://www.niaid.nih.gov/topics/coronavirus/Pages/default.aspx.. The study was funded, in part, by NIAID grant AI095569.. NIAID conducts and supports research-at NIH, throughout the United States, and worldwide-to study the causes of infectious and immune-mediated diseases, and to develop better means of preventing, diagnosing and treating ...

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged as a virus with a pathogenicity closer to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and a transmissibility similar to common cold coronaviruses (CoVs). In this review, we briefly discuss the features of the receptor-binding domain (RBD) and protease cleavage of the SARS-CoV-2 spike protein that enable SARS-CoV-2 to be a pandemic virus.

According to the abstract, Saudi Arabia and United States researchers write:. Risk factors for primary Middle East respiratory syndrome coronavirus (MERS-CoV) illness in humans are incompletely understood. We identified all primary MERS-CoV cases reported in Saudi Arabia during March-November 2014 by excluding those with history of exposure to other cases of MERS-CoV or acute respiratory illness of unknown cause or exposure to healthcare settings within 14 days before illness onset.. Using a case-control design, we assessed differences in underlying medical conditions and environmental exposures among primary case-patients and 2-4 controls matched by age, sex, and neighborhood. Using multivariable analysis, we found that direct exposure to dromedary camels during the 2 weeks before illness onset, as well as diabetes mellitus, heart disease, and smoking, were each independently associated with MERS-CoV illness. Further investigation is needed to better understand animal-to-human transmission of ...

Title: Two New Cases of MERS Coronavirus reported in Saudi Arabia.. Subject: Middle East Respiratory Syndrome Coronavirus in Saudi Arabia, daily update.. Source: Saudi Arabia Ministry of Health, full page: (LINK).. Code: [ ]. _____. MOH: 2 New Confirmed Coronavirus Cases Recorded. ___ New Cases Reported: [Sex, Age, Citizenship, Resident in, Health Status, Note ...

Understanding Middle East respiratory syndrome coronavirus (MERS-CoV) transmission in dromedary camels is important, as they consitute a source of zoonotic infection to humans. To identify risk factors for MERS-CoV infection in camels bred in diverse conditions in Burkina Faso, Ethiopia and Morocco, blood samples and nasal swabs were sampled in February-March 2015. A relatively high MERS-CoV RNA rate was detected in Ethiopia (up to 15.7%; 95% confidence interval (CI): 8.2-28.0), followed by Burkina Faso (up to 12.2%; 95% CI: 7-20.4) and Morocco (up to 7.6%; 95% CI: 1.9-26.1). The RNA detection rate was higher in camels bred for milk or meat than in camels for transport (p = 0.01) as well as in younger camels (p = 0.06). High seropositivity rates (up to 100%; 95% CI: 100-100 and 99.4%; 95% CI: 95.4-99.9) were found in Morocco and Ethiopia, followed by Burkina Faso (up to 84.6%; 95% CI: 77.2-89.9). Seropositivity rates were higher in large/medium herds (≥51 camels) than small herds (p = 0.061), in

The US FDA approved niclosamide, an oral anthelminthic drug, in 1982 for human use. It is also included in the essential medicines list of WHO. TFF used this drug to cure several million. It is recently repurposed to cure several viral infections that include SARS-CoV (severe acute respiratory syndrome coronavirus), Zika Virus, and MERS-CoV (Middle East respiratory syndrome coronavirus).. According to clinical trials, niclosamide has the potential to treat SARS-CoV-2. Low oral bioavailability and low absorption rate of niclosamide pose a challenge to develop it as an anti-viral therapy.. ...

The Saudi Arabia Ministry of Health (MOH) has reported a new case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in a citizen of Riyadh,

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related vira …

Novel coronavirus disease 2019 (2019-nCoV) is a global pandemic which threatens all over the world. The first cases were seen in Wuhan, China, in December 2019 (Guo et al. 2020; Chen et al. 2020). It has spread rapidly, and now, there are more than 2.3 million reported cases and 160,000 deaths worldwide. 2019-nCoV may cause multi-system infections especially respiratory infections such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) (Guo et al. 2020; Chen et al. 2020; Sanders et al. 2020). In some cases, infections may be mild (only cough or fever, etc.); however, in some cases, infections may be severe (acute respiratory failure with diffuse pneumonia). In severe cases, there is an exaggerated immune response with low peripheral lymphocyte levels and high cytokine levels. This mechanism of pathogenesis may be responsible for the multiple organ failures (Cao et al. 2019; Lin et al. 2020). In this early stage of the 2019-nCoV, the infection may be treated ...

Health officials say the 68-year-old man was in Bahrain on work-related crop cultivation business from April 18 to May 3. He traveled through Qatars airport on May 4.. One week after arriving back in South Korea he exhibited symptoms of fever and cough and was initially treated on an outpatient basis.. A couple of days later he was hospitalized and was confirmed positive for the Middle East Respiratory Syndrome coronavirus (MERS-CoV).. Health officials say the patient is in stable condition. In addition, they note that family contacts are being watched.. According to the World Health Organization (WHO), they have been notified of 1118 laboratory-confirmed cases of infection with MERS-CoV, including at least 423 related deaths as of May 18.. MERS was first reported in Saudi Arabia in 2012.. ...

The Ministry of Health (MOH} of the Kingdom of Cambodia and the Worl.d Health Organization (WHO) wish to inform the public that currently, there is no case related to the Middle East Respiratory Syndrome Corona virus (MERS-CoV) infections and the Ebola Virus Disease have been detected in Cambodia, so far.. 1. MERS-CoV is a novel coronavirus that causes acute respiratory illness in infected patients. The virus was first reported by the WHO in 2012, and thus far all cases worldwide remained associated with the Arabian Peninsula. The risk of a MERS-CoV outbreak in Cambodia remains low as sustained human-to-human transmission of the virus has not been reported.. The MOHs Department of Communicable Disease Control has, since 2013, been conducting MERS-CoV dissemination workshops in close collaboration with religious leaders, for communities at risk, that cover actions that should be undertaken by pilgrims betore, during and after their Hajj and Umrah pilgrhnages to the Middle East. There is ...

A member of the volunteer group Wuhan Emergency Team, installs a national flag on the car in Wuhan, central Chinas Hubei Province, Feb. 29, 2020. (Xinhua/Xiao Yijiu). The rapid rise of the epidemic in Wuhan has been contained, with the local outbreaks in Hubei outside Wuhan brought under control.. BEIJING, March 2 (Xinhua) -- China is in a nationwide mobilization to curb the spread of the novel coronavirus. Here are the latest developments:. -- Chinas daily new confirmed and suspected cases of the novel coronavirus disease (COVID-19) have seen an overall downward trend for two weeks. The number of newly discharged patients nationwide continues to show an upward trend, fluctuating around 3,000 in recent days.. The rapid rise of the epidemic in Wuhan has been contained, with the local outbreaks in Hubei outside Wuhan brought under control.. -- A team of doctors in a hospital in central Chinas Hunan Province successfully 3D printed the model of the nidus of a patient infected with the ...

novel coronavirus pneumonia novel coronavirus pneumonia data released by Canadian provinces were released at 18 PM August 13th. Canada has identified 390 new cases of new crown pneumonia in the past 24 hours, 121234 cases of cumulative cases, 6 cases of new deaths and 9012 cases of cumulative deaths. < / P > < p > of the newly confirmed cases, 76 cases were newly diagnosed in Alberta, 78 cases in British Columbia, 104 cases in Quebec, 78 cases in Ontario, 25 cases in Manitoba, 27 cases in Saskatchewan and 2 cases in New Brunswick. Six new deaths on the day were all from Quebec province. (head station reporter Zhang SEN). ...

The official name for the disease that is causing the 2019 novel coronavirus outbreak is COVID-19. The novel coronavirus that causes the disease is known as 2019-nCoV.. International and national health organizations and local health departments are monitoring the COVID-19 outbreak. Due to the situations rapidly changing nature, WOEMA recommends using the following websites to obtain the most current information:. American College of Occupational and Environmental Medicine: ACOEM ...

Have you ever heard about an emerging disease on a TV news program or in a newspaper and wanted to know more about it? Then you may be interested in the Disease Outbreak News (DON), published as needed by the World Health Organization, or WHO, a United Nations agency headquartered in Geneva, Switzerland. The web address is www.who.int/csr/don/en/ .. The DON reports the facts regarding where new disease outbreaks are occurring around the world and how many cases are involved. Most of the recent reports concern Middle East Respiratory Syndrome Coronavirus, or MERS-CoV. MERS-CoV cases are showing up in Saudi Arabia, Qatar and the United Arab Emirates, with a few cases recently noted in China and South Korea.. While not every ARES member would benefit from these reports, members who are also medical professionals might. Wright-Patterson AFB employees and contractors regularly travel to many of the countries mentioned above, and its just possible that some of these emerging illnesses may someday ...

A novel betacoronavirus associated with lethal respiratory and renal complications was recently identified in patients from several countries in the Middle East. We report the deep genome sequencing of the virus directly from a patients sputum sample. Our high-throughput sequencing yielded a substantial depth of genome sequence assembly and showed the minority viral variants in the specimen. Detailed phylogenetic analysis of the virus genome (England/Qatar/2012) revealed its close relationship to European bat coronaviruses circulating among the bat species of the Vespertilionidae family. Molecular clock analysis showed that the 2 human infections of this betacoronavirus in June 2012 (EMC/2012) and September 2012 (England/Qatar/2012) share a common virus ancestor most likely considerably before early 2012, suggesting the human diversity is the result of multiple zoonotic events.

Thanks to FluTrackers for picking up this report from the Saudi Gazette: Ministry accused of falsifying information on MERS cases. It confirms the Arabic reports mentioned here yesterday. A Saudi poet who contracted the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)...

TY - JOUR. T1 - History and recent advances in coronavirus discovery. AU - Kahn, Jeffrey. AU - McIntosh, Kenneth. PY - 2005/11. Y1 - 2005/11. N2 - Human coronaviruses, first characterized in the 1960s, are responsible for a substantial proportion of upper respiratory tract infections in children. Since 2003, at least 5 new human coronaviruses have been identified, including the severe acute respiratory syndrome coronavirus, which caused significant morbidity and mortality. NL63, representing a group of newly identified group I coronaviruses that includes NL and the New Haven coronavirus, has been identified worldwide. These viruses are associated with both upper and lower respiratory tract disease and are likely common human pathogens. The global distribution of a newly identified group II coronavirus, HKU1, has not yet been established. Coronavirology has advanced significantly in the past few years. The SARS epidemic put the animal coronaviruses in the spotlight. The background and history ...

This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 29 September-5 October 2019 and includes updates on Ebola virus disease, extensively drug-resistant Klebsiella pneumoniae, mass gathering monitoring (Japan, Rugby World Cup 2019), Middle East respiratory syndrome coronavirus, Plasmodium cynomolgi infection, poliomyelitis, West Nile virus, and yellow fever. ...

Collaborative efforts were used in the identification of the MERS-CoV.[94] Egyptian virologist Dr. Ali Mohamed Zaki isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old Saudi Arabian man with pneumonia and acute renal failure.[7] After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice.[95] Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum pan-coronavirus real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the RdRp screen was positive.[94]. On 15 September 2012, Dr. Zakis findings were posted on ...

Collaborative efforts were used in the identification of the MERS-CoV.[94] Egyptian virologist Dr. Ali Mohamed Zaki isolated and identified a previously unknown coronavirus from the lungs of a 60-year-old Saudi Arabian man with pneumonia and acute renal failure.[7] After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice.[95] Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum pan-coronavirus real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the RdRp screen was positive.[94] On 15 September 2012, Dr. Zakis findings were posted on ...

Estimation of the asymptomatic ratio of novel coronavirus infections (COVID-19). - Studies on epidemic forecasting - Coronavirus outbreak

As this global concern grows by the minute so should your concern to take action into protecting yourself and your loved ones from this worldwide threat. According to the most recently published article by JAMA (An International peer-reviewed medical journal association), the Coronavirus disease 2019 (COVID-19) is a respiratory illness that results from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Furthermore, the article shares that following initial reports of disease outbreak in China, COVID-19 has spread worldwide with cases identified in at least 67 countries across 6 continents. So if this is an acute respiratory illness why is the world-wide population running out of toilet paper? Ok, I must admit this is funny but not really!. What is coronavirus disease 2019?. According to the CDC, the Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first ...

Till the date, the deadly novel coronavirus has infected 210 countries and territories around the world. The world has reported 3,074,553 positive cases, 211,773 deaths so far. Doctors and researchers across the world are trying to develop drugs and vaccines to prevent the deadly coronavirus. Under such circumstances, hospitals in New York have been quietly testing a common over-the-counter drug as a probable cure for coronavirus (COVID-19) after doctors in China found that elderly survivors were consuming it.. Have you ever heard of a drug named, famotidine? This medicine is especially used for peptic ulcers and GERD (Gastroesophageal Reflux Disease) and sold in oral form under brand name Pepcid. Famotidine is the active compound in the over-the-counter (OTC) heartburn drug Pepcid. It is being examined to treat hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for causing the coronavirus disease 2019 (COVID-19), by Northwell Health in ...

MERS should be considered when a severe respiratory illness occurs in the 2 weeks following residence in or travel to the Middle East or areas of outbreak, and/or close contact with infected individuals. The majority of cases are the result of human-to-human transmission, with peaks of confirmed ...

Coronavirus in Texas 3/27: U.S. House approves coronavirus spending bill By Texas Tribune Staff, The Texas Tribune March 27, 2020 Coronavirus in Texas 3/27: U.S. House approves coronavirus spending bill was first published by The Texas Tribune, a nonprofit, nonpartisan media organization that informs Texans - and engages with them - about public policy, politics, government and statewide issues. Fridays biggest developments Abbott deploys National Guard to help with testing sites, healthcare Six Lubbock nursing home residents test positive for COVID-19 Latest report for Texas: 1,731 COVID-19 cases, 23 deaths U.S. House approves coronavirus spending bill Texas eases child care regulations to help low-income parents during pandemic [6:41 p.m.] As part of an ongoing response to the economic hit Texans face due to the new coronavirus, Gov. Greg Abbott agreed to ease regulations for child care centers serving low-income children through state subsidies. Now, child care providers will receive ...

Youve likely heard about the 2019 Novel Coronavirus (2019-nCoV) that originated in China late last year. The first case in the United States was reported at Providence Regional Medical Center- Everett last week. Coronaviruses are the cause of roughly 10% of all common colds.. This particular strain, however, is more dangerous than a common cold. Symptoms include fever, cough, and shortness of breath. Symptoms can appear in as few as two days or as long as 14 days after exposure. While we are still analyzing exactly how this virus is transmitted, it appears that person to person spread happens mainly via respiratory droplets produced when an infected person coughs or sneezes, similar to how influenza is transmitted.. If you have travelled to, or have been in close contact with, someone who has travelled to China and you develop fever, cough, or shortness of breath, call 911 or your doctors office. Before going to the doctors office or hospital please call ahead and tell them that you may have ...

The U.S. Centers for Disease Control and Prevention confirms the first U.S. case of the newly-emerging Middle East Respiratory Virus or MERS within U.S. borders. Jillian Kitchener reports.

Sigma-Aldrich offers abstracts and full-text articles by [Shamsudeen F Fagbo, Leila Skakni, Daniel K W Chu, Musa A Garbati, Mercy Joseph, Malik Peiris, Ahmed M Hakawi].

Bats, the source of so many viruses, could be the origin of Wuhan coronavirus, say experts - CNN. Deadly coronavirus may have originated in bats: researchers - Weve detected unusual activity from your computer network Up Next Close Rob Gronkowski opens up about everything.. Furthermore, genes for different immune cell subsets, T-cell receptors TCRs , cytokines and chemokines, and interferon-related genes were detected, while genes encoding for natural killer NK cell receptors were largely absent. Meyerholz D. DeGroote fellowship awarded to A. Bats are known to harbor a wide range of viruses including many that are highly pathogenic in humans. The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase. In the study, published today Jan. In , a novel alphacoronavirus was identified in an outbreak of respiratory disease in alpacas in the US, which is geographically separated from the bat species that harbor ...

Carlos del Rio executive associate dean for Emory University School of Medicine at Grady Health System, published important information for clinicians in JAMA detailing the 2019 novel coronavirus pandemic, saying that the outbreak is doubling in case size every 6.4 days.

WASHINGTON - Today, the U.S. Environmental Protection Agency (EPA) took steps to provide additional flexibilities to manufacturers of disinfectants and other pesticides. EPA intends for these flexibilities to increase the availability of products for Americans to use against the novel coronavirus. After meeting with stakeholders last week and discussing supply chain challenges posed by the pandemic, EPA is allowing manufacturers to obtain certain inert ingredients-or inactive ingredients like sodium chloride or glucose-from different suppliers without checking with the agency for approval.. EPA is committed to doing our part to help ensure American families, communities, business and hospitals have access to as many effective surface disinfectant products as possible, said EPA Administrator Andrew Wheeler. There is no higher priority for the Trump Administration than protecting the health and safety of Americans, and the steps we are taking today are helping put more products on the shelves ...

WASHINGTON - Today, the U.S. Environmental Protection Agency (EPA) took steps to provide additional flexibilities to manufacturers of disinfectants and other pesticides. EPA intends for these flexibilities to increase the availability of products for Americans to use against the novel coronavirus. After meeting with stakeholders last week and discussing supply chain challenges posed by the pandemic, EPA is allowing manufacturers to obtain certain inert ingredients-or inactive ingredients like sodium chloride or glucose-from different suppliers without checking with the agency for approval.. EPA is committed to doing our part to help ensure American families, communities, business and hospitals have access to as many effective surface disinfectant products as possible, said EPA Administrator Andrew Wheeler. There is no higher priority for the Trump Administration than protecting the health and safety of Americans, and the steps we are taking today are helping put more products on the shelves ...

We are monitoring closely the Covid-19 (Novel Coronavirus) situation and our task force is continually assessing and responding to changes.

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By DAVID J. HILL. The World Health Organization on Thursday declared the outbreak of novel coronavirus a global emergency. While that news may stoke some anxiety among members of the UB community, university leaders want to assure students, faculty and staff that proper precautions are being taken to ensure the health and safety of everyone on campus.. At UB, a team of experienced professionals continues to monitor the situation on campus and has been coordinating with its partners in Erie County, New York State and the U.S. Centers for Disease Control and Prevention.. Consistent communication has been key to keeping the campus community apprised of important information on novel coronavirus, including basic tips on how members of campus can monitor their health.. UB created a coronavirus information website, which contains a list of frequently asked questions, a video featuring Susan Snyder, UBs director of student health services, as well as links to advisories from the CDC and the U.S. ...

TUESDAY, April 21, 2020 (HealthDay News) -- An early analysis of antibody testing from Los Angeles County finds a coronavirus infection rate that is up to 55 times the number of confirmed COVID-19 cases.. According to the researchers behind the study, the vast majority of people infected with the new coronavirus may be going without symptoms or have minimal symptoms.. Its one of the first in-depth analyses of local population infection rates conducted in the United States.. Los Angeles Countys population totals more than 10 million. As the research team noted, by early April, there were 7,994 confirmed cases of COVID-19 reported in the county, including 600 COVID-19 deaths. But new findings from the first round of ongoing antibody blood testing of county residents showed that about 4.1% of adults had antibodies to the coronavirus.. Adjusting for any statistical margin of error, that suggests that between 2.8% to 5.6% of the countys adults have antibodies to the coronavirus, which translates ...

Coronaviruslike viruses previously have been identified in feces of diarrheic foals and adult horses (1, 7, 8, 13, 17). In the present study, a coronavirus associated with diarrhea in a young foal was serially propagated in cell culture and partially characterized. The virus was identified as a coronavirus based on (i) virion size and morphology, (ii) antigenic relatedness to BCV and HEV as determined by serological procedures, and (iii) genetic relatedness to BCV, HCV strain OC43, and MHV as determined by N gene sequence analysis. The virus tentatively is identified as equine coronavirus (ECV) based on the origin of the virus.. The coronavirus N protein has been shown to be highly variable in amino acid composition between the viruses that comprise the three coronavirus antigenic groups but highly conserved within these groups (27, 30). In the present study, a high degree of identity (66.7 to 90.1%) was observed between the N protein sequences of ECV strain NC99 and N protein sequences of group ...

My eyes are killing me…is it coronavirus? If youve found yourself wondering if youve picked up COVID-19 through your eyes, youre not alone. The coronavirus presents with the usual flu symptoms, and pink, irritated eyes with discharge is one of them. Heres what you need to know about the connection between conjunctivitis and coronavirus.. Pink eye can be environmental, viral or bacterial. If you think you have conjunctivitis, or pink eye, there could be several causes. This time of year, you could be reacting to pollen, mold, chemicals and other allergens in the air1. Sometimes bacteria can cause an eye infection flare-up but, by far, the majority of cases of pink eye are caused by viruses. One of these viruses could be coronavirus. But it just as easily could be another culprit.. According to the American Academy of Ophthalmologists, there are cases that show that viruses that cause conjunctivitis were likely transmitted through the air to the eye. It is possible that the coronavirus could ...