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Gonzalez, J.M., Gomez-Puertas, P., Cavanagh, D., Gorbalenya, A.E. & L. Enjuanes 2003. A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae. Arch. Virol.. 148: 2207-2235 ...
US - The number of pig farm samples that are confirmed positive for porcine epidemic diarrhoea virus (PEDV) in the last week was 16, while no premises were confirmed with porcine deltacoronavirus (PDCoV) or the dual infection (PEDV and PDCoV).
Infectious bronchitis, a disease of chickens caused by Avian coronavirus infectious bronchitis virus (IBV), leads to severe economic losses for the poultry industry worldwide. Various attempts to control the virus based on vaccination strategies are performed. However, due to the emergence of novel genotypes, an effective control of the virus is hindered. In 1996, a novel viral genotype named IBV-QX was reported for the first time in Qingdao, Shandong province, China. The first appearance of an IBV-QX isolate in Europe was reported between 2003 and 2004 in The Netherlands. Subsequently, infections with this genotype were found in several other European countries such as France, Italy, Germany, United Kingdom, Slovenia, and Sweden. The present report describes the use of a new set of degenerate primers that amplify a 636-bp fragment within the S1 gene by reverse transcription polymerase chain reaction to detect the occurrence of IBV-QX infection in Switzerland. ...
Avian infectious bronchitis virus (IBV), a coronavirus, requires initial isolation in, and adaptation to, chicken embryos (CE) before transfer to primary avian cell and chicken tracheal organ cultures. These are the only presently known cell cultures in which IBV replicates and produces cytopathic effects (c.p.e.) in serial passage (Estola, 1966; Cunningham, 1970). Monkey kidney cells have been reported (Fahey & Crawley, 1956; Steele & Luginbuhl, 1964) to support relication of IBV without c.p.e. when first inoculated with virus propagated in CE. Attempts apparently were not made to passage the virus in these cells. Direct haemagglutination (HA) is not a normal property of IBV (Biswal, Nazerian & Cunningham, 1966) or of the human coronaviruses (Kapikian, 1969). However, human coronaviruses OC 38 and OC 43 adapted to suckling mouse brain (McIntosh et al. 1969) cause direct HA (Kaye & Dowdle, 1969) and produce syncytia and plaques in African green monkey kidney and BSC-1 cells (Bruckova,
Avian infectious bronchitis virus (IBV) is the type species of the family Coronaviridae (Siddell et al., 1983). It has a large positive-stranded RNA genome which has been estimated at 20-24 kilobases...
A virulent avian infectious bronchitis virus (IBV) was isolated from 30-day-old broiler chickens that exhibited respiratory symptoms, nephropathologic lesions, and a high proportion of deaths in the Peoples Republic of China during 2005. The strain, designated YN, was genetically and pathologically characterized. Phylogenetic analysis showed that YN and most of the previously characterized IBV isolates found in China were phylogenetically classified into 2 main genetic clusters. The YN isolate caused severe lesions and resulted in deaths of 65% in experimental infections of 30-day-old specific-pathogen-free chickens. Tracheal and severe kidney lesions developed in all infected birds, confirming the ability of YN strain to induce both respiratory and renal disease. IBV antigens were detected by immunohistochemical analysis in the trachea, lung, kidney, and bursa, consistent with histopathologic observations, virus isolation, and reverse transcription PCR detection. We showed that YN IBV exhibits severe
The epididymal region of the rooster consists of the rete testes, the efferent ductules and the epididymal duct. In the epididymal region, the spermatozoa gain the ability to move and acquire surface proteins. The specialized microenvironment of the epididymal region is vital for these developments to occur. A dysfunction of the epididymal region, epididymal stones, has been shown to affect fertility in the rooster. The cause of these epididymal stones was investigated and avian infectious bronchitis virus (AIBV) has been identified as a cause. AIBV is a highly contagious respiratory disease in chickens. The pathogenesis of AIBV in the female reproductive tract has been well studied; however, there have been few studies concerning the effects of AIBV on the rooster reproductive tract. Therefore this investigation was undertaken to identify the role of AIBV in epididymal stone formation and to characterize changes in seminal plasma composition. Specific objectives were: (1) to determine if AIBV ...
A virus isolated from a respiratory disease in chickens was identified as infectious bronchitis virus (IBV). By serum neutralisation tests the virus was shown to be serologically distinct from the Massachusetts type but to possess a one-way relationship with the Connecticut type. Experimentally, it caused a relatively mild respiratory disease in baby chicks. Vaccination of young chicks with H-120 Massachusetts IBV vaccine afforded a high degree of protection against challenge with the isolate. Some problems relating to the isolation and classification of field strains of IBV are briefly discussed.. ...
Looking for online definition of Coronaviridae in the Medical Dictionary? Coronaviridae explanation free. What is Coronaviridae? Meaning of Coronaviridae medical term. What does Coronaviridae mean?
Avian infectious bronchitis virus (IBV) is a major respiratory disease-causing agent in birds that leads to significant losses. Dendritic cells (DCs) are specialised cells responsible for sampling antigens and presenting them to T cells, which also play an essential role in recognising and neutralising viruses. Recent studies have suggested that non-coding RNAs may regulate the functional program of DCs. Expression of host non-coding RNAs changes markedly during infectious bronchitis virus infection, but their role in regulating host immune function has not been explored. Here, microarrays of mRNAs, miRNAs, and lncRNAs were globally performed to analyse how avian DCs respond to IBV. First, we found that IBV stimulation did not enhance the maturation ability of avian DCs. Interestingly, inactivated IBV was better able than IBV to induce DC maturation and activate lymphocytes. We identified 1093 up-regulated and 845 down-regulated mRNAs in IBV-infected avian DCs. Gene Ontology analysis suggested that
Coronavirus infectious bronchitis virus is a positive-stranded RNA virus, which synthesises a 3-coterminal nested set of six subgenomic RNAs. Subgenomic RNA transcription and genome replication are...
Avian infectious bronchitis (IB), caused by avian infectious bronchitis virus (IBV), is a worldwide endemic disease of chickens that affects all branches of the poultry industry. Multiple geno/serotypes occur, and low vaccine cross-protection results from the highly divergent IBV types. In view of the lack of consistent data on the economic losses caused by IB and the poor protection resulting from the use of the Massachusetts type as a live vaccine in Brazil, this survey aimed to estimate the losses per 1,000 birds in broiler and breeder flocks positive for IBV. Thirty-two different IBV genetic types were found. In breeders, the total loss per 1,000 birds was US$3,567.4 and US$4,210.8 at 25-26 and 42 weeks old, respectively, whereas in broilers (48 days old), the estimated loss was US$266.3 per 1,000 birds. Taken together, the results show a significant and measurable economic impact on the broiler and breeder industries, with an age-dependent increasing trend and an association with multiple ...
Over the past years the research, we have been able to clone and propagate full length coronavirus (CoV) cDNAs from several CoVs using vaccinia virus as eukaryotic cloning vector. The reverse genetic system is based upon the in vitro transcription of infections RNA from a cloned full-length cDNA copy of a CoV genome, and the introduction of nucleotide changes, deletions or insertions is facilitated by vaccinia virus-mediated recombination. The reverse genetic system has proven to be rapid, robust and versatile and is available in the laboratory of Dr. Thiel for the generation of recombinant prototype viruses of all major CoV phylogenetic lineages, namely for HCoV 229E, type-I and type-II Feline CoVs (genus Alphacoronavirus), Mouse Hepatitis Virus strain A59, SARS-CoV (genus Betacoronavirus), Avian Infectious Bronchitis Virus (genus Gammacoronavirus).. One of our long-term goals is to study CoV replication in order to develop strategies to prevent and control CoV infections. Thus, we have applied ...
Over the past years the research, we have been able to clone and propagate full length coronavirus (CoV) cDNAs from several CoVs using vaccinia virus as eukaryotic cloning vector. The reverse genetic system is based upon the in vitro transcription of infections RNA from a cloned full-length cDNA copy of a CoV genome, and the introduction of nucleotide changes, deletions or insertions is facilitated by vaccinia virus-mediated recombination. The reverse genetic system has proven to be rapid, robust and versatile and is available in the laboratory of Dr. Thiel for the generation of recombinant prototype viruses of all major CoV phylogenetic lineages, namely for HCoV 229E, type-I and type-II Feline CoVs (genus Alphacoronavirus), Mouse Hepatitis Virus strain A59, SARS-CoV (genus Betacoronavirus), Avian Infectious Bronchitis Virus (genus Gammacoronavirus).. One of our long-term goals is to study CoV replication in order to develop strategies to prevent and control CoV infections. Thus, we have applied ...
The Cornell University Animal Health Diagnostic Center (AHDC) has seen a rise in the diagnosis of equine enteric coronavirus cases since initial outbreaks were investigated starting in 2010. The AHDC Veterinary Support Services veterinarians are attributing this increase in equine enteric coronavirus in our area of the Northeast to improved awareness of the disease and
Infectious bronchitis (IB) is an acute, highly contagious, and economically important viral disease of chickens. The S1 subunit from Spike (S) protein plays the major role in protective immunity and is involved in the host-virus interactions, as well as infectious bronchitis virus (IBV) serotyping. Aim of the present study was multi-aspect analysis of the molecular and immunological features of 5 part belonging to the S1 glycoprotein sequence of Iranian 793/B IBV strain isolates. This might ideally help in characterization, prevention, and vaccine development. The tissue samples were prepared, followed by virus isolation, reverse transcription polymerase chain reaction and restriction fragment length polymorphism analysis. In addition, sequencing and registration of the sequences in the National Center for Biotechnology Information were performed. Moreover, 12 sequences were retrieved from Fars province, Iran. The next steps included evaluation of conservation/variability along the sequences,
Infectious bronchitis virus (IBV) causes losses of £23.6M a year to th...A pre-hatching prototype vaccine virus which provides immunity to IBV ...IBV is the worst infectious disease in terms of economic loss to the U...The researchers funded by the Biotechnology and Biological Sciences R...The scientists have extracted a so-called spike protein from a pathoge...,In-shell,vaccine,for,chick,disease,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Infectious bronchitis virus (IBV) causes highly contagious respiratory or urogenital tract diseases in chickens. genes, with the 3 untranslated area (UTR), which differs from Ark-like strains. Phylogenetic evaluation and series alignments demonstrate that 1196681-44-3 manufacture Md27 can be a chimera including different gene sections that are most carefully linked to the SE17, JMK and Conn strains. This current research provides proof for genomic mutations and intergenic recombination which have occurred in the advancement of IBV stress Md27. can be a pathogen of home chickens that triggers acute, contagious respiratory disease [1 extremely,2]. The IBV genome consists of an individual, positive-strand RNA molecule, which is approximately 27.6 kb long and includes a cap in the 5end and poly (A) tail in the 3end [3]. It comprises ten open up reading structures (ORFs) as well as the 1st 20 kb genome comprises of ORF1, which really is a replicase gene. The replicase offers two ORFs, 1a and 1b [4]; ...
Infectious bronchitis virus (IBV) variants constantly emerge and pose economic threats to poultry farms worldwide. Numerous studies on the molecular and pathogenic characterization of IBV variants have been performed between 2007 and 2017, which we have reviewed herein. We noted that viral genetic mutations and recombination events commonly gave rise to distinct IBV genotypes, serotypes and pathotypes. In addition to characterizing the S1 genes, full viral genomic sequencing, comprehensive antigenicity, and pathogenicity studies on emerging variants have advanced our understanding of IBV infections, which is valuable for developing countermeasures against IBV field outbreaks. This review of IBV variants provides practical value for understanding their phylogenetic relationships and epidemiology from both regional and worldwide viewpoints.
Virus classification of Infectious Bronchitis virus (IBV) according to reverse transcriptase polymerase chain reaction or virus neutralization.
This thesis deals with the molecular characterization and detection of infectious bronchitis virus (IBV), an important pathogen that causes heavy losses in the poultry populations worldwide. The aim of the research was to better understand the molecular characteristics of the virus and to investigate the factors behind the continuous emergence of new genetic variants and the occurrence of outbreaks. The studies showed that the viral genome is under a continuous evolution, due to mutations, strong selective pressure and recombination events. These forces lead to a wide genetic diversity and the generation of new variants of this virus. The viral genes encoding the spike, envelope and membrane proteins can be considered the main genomic regions, which are indicating the evolution processes of IBV. The various strains contain specific structural and functional motifs in their genes and the alterations in these motifs may affect the infection biology of the virus. The constant emergence of new ...
The nucleotide sequences of a region including S1, S2, 3a, 3b and E genes of twenty-seven infectious bronchitis virus (IBV) isolates in Korea between 1990-2011 were determined and phylogenetic and computational recombination analyses were conducted. The sizes of coding regions of some genes varied among IBV isolates due to deletion or insertion of nucleotides; the nucleotide similarities of S1, S2, 3a, 3b and E genes among the 27 isolates were 75.9%-100.0%, 85%-100.0%, 64.0%-100.0%, 60.4%-100.0% and 83.1%-100.0%, respectively. According to phylogenetic analysis of S1 gene, the 27 isolates were divided into five genotypes, Mass, Korean-I (K-I), QX-like, KM91-like and New cluster 1. The phylogenetic trees based on the S2, 3a, 3b, E genes and S1-S2-3a-3b-E (S1-E) region nucleotide sequences did not closely follow the clustering based on the S1 sequence. The New cluster 1 prevalent during 2009 and 2010 was not found in 2011 but QX-like viruses became prevalent in 2011. The recombination analysis revealed
Whats further perplexing about the situation is the fact that it took two months for the full gene sequence of this mutated coronavirus strain to be released by the National Institute of Virology, which received it a while back after it was collected from a patient in Kerala.. Why it took this Indian government agency so long to release it has created more questions than there are answers as to just how serious this situation truly is. Even more concerning is a warning put out by the South China Morning Post, admittedly a communist Chinese government propaganda outlet, that theres much more to come in the area of mutations.. "[T]here is real concern growing that thousands of strains sampled and sequenced are just the tip of the iceberg - and great variety increases the risk that new strains will require new vaccines in the same way the flu virus does," the paper reported.. Even so, the race is on to release one, two, or even seven, in the case of billionaire eugenicist Bill Gates, different ...
New disinfectant CARLYSAFE-RTU has the following functions: Virucidal, Bactericidal, Fungicidal and Levuricidal. Ready to use, CARLYSAFE-RTU is intended for disinfection in sensitive areas which require high hygiene standards. CARLYSAFE-RTU has been tested by a renowned laboratory on HCoV-229E and according to EN 14476+A2. ((human coronavirus strain known as Covid-19 mimic). Complies with the European Biocidal Regulation (528/2012) - TP02 and TP04, CARLYSAFE-RTU can be used for the treatment of food surfaces, in indirect contact (Decree of 19/12/2013). You can download the technical documentation by clicking here. ...
Infectious bronchitis is a disease of chickens causing respiratory symptoms and affecting the urogenital tract of the chicken. Vaccination with Nobilis IB Ma5, Nobilis IB 4/91 and Nobilis IB inac. prevents disease.
US - The number of pig farm samples that were confirmed positive for porcine epidemic diarrhoea virus (PEDV) in the last week was 78. There has been one premises confirmed with having porcine delta coronavirus (PDCoV) and five with the dual infection (PEDV and PDCoV), in the 8 October 2015 weekly report.
PubMed journal article: A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS. Download Prime PubMed App to iPhone, iPad, or Android
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Animal health company, Zoetis, has obtained a full license from the US Department of Agriculture (USDA) to sell Poulvac Bron GA 08, the first commercially available vaccine to reduce disease caused by Georgia 2008 (GA 08) Type infectious bronchitis virus (IBV) in poultry.
望月 雅美 , 光武 由香理 , 宮之原 佑子 , 東原 孝 , 清水 孜 , 宝達 勉 The journal of veterinary medical science 59(4), 253-258, 1997-04-25 CiNii PDF - オープンアクセス 医中誌Web 参考文献30件 ...
TY - JOUR. T1 - Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses. AU - Vennema, Harry. AU - Poland, Amy. AU - Foley, Janet E. AU - Pedersen, Niels C. PY - 1998/3/30. Y1 - 1998/3/30. N2 - Feline infectious peritonitis virus (FIPV) strains from six cats and three different geographic areas were compared genetically with feline enteric coronavirus (FECV) isolates obtained from cats inhabiting the same environments. Sequence comparisons were made from 1.2- to 8.9-kb segments on the 3 end of the genome. FECV/FIPV pairs from the same catteries or shelters were 97.3-99.5% related but were genetically distinct from FIPV and FECV strains obtained from cats living in geographically distinct environments. The high genetic similarity between FECVs and FIPVs from the same environment strongly suggested a common ancestry. Based on the presence of deletion mutations in the FIPVs and not in the FECVs, it was concluded that FIPVs evolved as mutants of FECVs. The ...
Cell-mediated immunity is thought to play a decisive role in protecting cats against feline infectious peritonitis (FIP), a progressive and lethal coronavirus disease. In view of the potential of DNA vaccines to induce cell-mediated responses, their efficacy to induce protective immunity in cats was evaluated. The membrane (M) and nucleocapsid ... read more (N) proteins were chosen as antigens, because antibodies to the spike (S) protein of FIP virus (FIPV) are known to precipitate pathogenesis. However, vaccination by repeated injections of plasmids encoding these proteins did not protect kittens against challenge infection with FIPV. Also, a prime boost protocol failed to afford protection, with priming using plasmid DNA and boosting using recombinant vaccinia viruses expressing the same coronavirus proteins. Because of the role of IL-12 in initiating cell-mediated immunity, the effects of co-delivery of plasmids encoding the feline cytokine were studied. Again, IL-12 did not meet expectations ...
Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis. ...
Feline infectious peritonitis is a fatal viral disease which is currently incurable by drugs. Also, there are no effective vaccines. Cyclosporin A (CsA) was recently shown in vitro to exert potent antiviral activities on several virus-host systems, including various coronaviruses. However, whether CsA has clinically relevant activity in vivo resistant to various coronaviruses, including the severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses, remains unknown. Herein, the authors report that treatment with CsA caused a sustained reduction in pleural fluid volume and viral copy number in a cat diagnosed with effusive feline infectious peritonitis. ...
Infectious bronchitis virus (IBV) is a member of family Coronaviridae and is classified into group 3 of the Coronaviruses. The virus is a single-stranded positive-sense RNA virus with a genome of 27kbp. IBV is a highly infectious disease of chickens that results in high morbidity with moderate to severe mortality depending on the strain involved, age of the birds, and immune status of the chickens. Multiple worldwide investigations indicate that differentiation within the S1 glycoprotein gene can lead to serotype variation within the IBV species. In this study 46 isolates collected over two years from broiler and broiler breeder flocks and eight historical isolates were analyzed. Forty one isolates originated from the KwaZulu-Natal region whilst the remaining thirteen were isolated from 4 other poultry-dense provinces. The S1 gene was sequenced and compared to determine variation between South African isolates, as well as global sequences submitted to Genbank. The results indicate the division ...
Enjuanes L, Brian D, Cavanagh D, Holmes K, Lai MMC, Laude H, Masters P, Rottier P, Siddell SG, Spaan WJM et al (2000) Coronaviridae. In: van Regenmortel MHV, Fauquet CM, Bishop DHL, Carstens EB, Estes MK, Lemon S, Maniloff J, Mayo M, McGeoch DJ, Pringle CR, Wickner RB (eds): Virus Taxonomy. Classification and Nomenclature of Viruses. Academic Press, San Diego, 835-849Google Scholar ...
An ongoing outbreak of SARS-CoV-2 has raised global concerns in 2020 with millions of confirmed cases, which is identified as another clade within the Betacoronavirus genus, Coronaviridae family. This article will help to figure out how this kind of virus infect human body by introducing the interaction between the four stages of the life cycle of coronavirus and the cytoskeleton.. The first stage: virus invasion. The first stage of coronavirus infection is Spike(S) protein-mediated attachment to the cell surface via S protein to the ceramide acid portion (acidic carbohydrate with 9 carbon atoms) or heparan sulfate. This infection strategy is very effective because there are many types of receptor molecules on the surface of all mammalian cells, thus creating abundant conditions for plasma membrane attachment. After binding, the virus particles actively rearrange the cytoskeleton by regulating the FAK/Cofilin/Rac/Cdc42 pathway.. The second stage: transport. In the second phase, some studies ...
Haijema et al., 2004: Haijema BJ, Volders H, Rottier PJ. Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis. Journal of virology. 2004; 78(8); 3863-3871. [PubMed: 15047802 ...
A rear projection display device capable of reducing the depth of a display device itself, comprising an optical engine, first, second, third reflective mirrors arranged at such positions as to be easily held integrally with each other, a fourth reflective mirror, a plane reflective mirror for turn-back of light flux, and a screen.
So I called 811 last night and as long as pain is lessening I dont have to go to tge doctor. Tonight though there is a spot on one of my bruises that is suddenly far more paunful when touched. And I am panicked. I dobt want to call 811 yet, cause its been really…
FELINE INFECTIOUS PERITONITIS Navies 2011 Feline Infectious Peritonitis (FIP) is a progressive, almost always fatal, viral disease of domestic cats. It affects some exotic cats, with the cheetah being particularly susceptible. It does not affect non-feline species, such as dogs. Etiology or Cause      Field strains of feline coronavirus vary in their ability to induce FIP. Some isolates cause FIP (feline infectious peritonitis virus [FIPV]others cause more localized GI disease) Mutations from feline enteric coronavirus to FIPV occur. FIP is thought to result from a mutation of the virus within the body, combined with the response of the immune system, leading to inflammation in various organ systems. FIPV and canine coronavirus are very closely related antigenically and may have crossed between hosts. Feline coronaviruses are fairly stable in the environment and, once dry, can survive for 4-6 wk. They are enveloped viruses and are destroyed by most household disinfectants, ...
Feline coronavirus (FCoV) is endemic in feral cat populations and cat colonies, frequently preceding outbreaks of fatal feline infectious peritonitis (FIP). FCoV exhibits 2 biotypes: the pathogenic disease and a benign infection with feline enteric coronavirus (FECV). Uncertainty remains regarding whether genetically distinctive avirulent and virulent forms coexist or whether an avirulent form mutates in vivo, causing FIP. To resolve these alternative hypotheses, we isolated viral sequences from FCoV-infected clinically healthy and sick cats (8 FIP cases and 48 FECV-asymptomatic animals); 735 sequences from 4 gene segments were generated and subjected to phylogenetic analyses. Viral sequences from healthy cats were distinct from sick cats on the basis of genetic distances observed in the membrane and nonstructural protein 7b genes. These data demonstrate distinctive circulating virulent and avirulent strains in natural populations. In addition, 5 membrane protein amino acid residues with functional
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What causes FIP?. FIP develops as a result of an adverse reaction to the feline enteric coronavirus. The feline enteric coronavirus is shed by infected animals in feces. An infected cat may shed some of the virus in feces, and when another cat comes along to investigate, the virus infects the new cat through the mouth and nose. When the cat is infected, the virus may be destroyed by the immune system or it may mutate, allowing it to take advantage of the hosts body and live undetected. This leads to the hosts body becoming infiltrated with the virus, causing pyogranulomas. Some cats infected by feline enteric coronavirus present with non-threatening flu like symptoms, and some develop FIP.. ...
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Feline Infectious Peritonitis (FIP) is a fatal disease in cats caused by a Coronavirus. During FIPv infection the T-cell population is depleted. This is seen in many other diseases, such as measles and AIDS. In these two diseases, the Dendritic Cell (DC) has been shown to play a role ... read more in T-cell depletion. This study endeavours to prove if such a mechanism exists in FIP. In order to investigate permissiveness of DCs for FIPv, a growth curve was produced. This growth curve showed prolonged viral reproduction to intermediate titres. As T-cell depletion during FIPv infection occurs at least partly through apoptosis, a TUNEL assay was used to evaluate this. FACS analysis of infected and non-infected co-cultures of DCs with Thymocytes revealed no difference in apoptosis levels. These data suggest that T-cell depletion during FIPv infection does not occur through apoptosis initiated by FIPv-infected DCs. show less ...
TY - JOUR. T1 - Pathogenicity and sequence analysis studies suggest potential role of gene 3 in virulence of swine enteric and respiratory coronaviruses. AU - Paul, Prem S. AU - Vaughn, Eric M.. AU - Halbur, Patrick G.. PY - 1997/7/4. Y1 - 1997/7/4. N2 - Coronaviruses have been commonly associated with enteric and respiratory diseases. Two of the swine coronaviruses, namely transmissible gastroenteritis virus (TGEV) and porcine respiratory coronavirus (PRCV) have been extensively studied. TGEV replicates in both the enteric and respiratory tracts and causes enteric disease, whereas, PRCV replicates in the respiratory tract with limited to no replication in the enteric tract. We have isolated PRCV from swine herds with respiratory disease and have reproduced moderate pneumonia in gnotobiotic and conventionally reared pigs with two of the PRCV isolates. We have also identified two PRCV isolates with low virulence. One consistent difference that we have observed between PRCV isolates of different ...
FIP is the most misdiagnosed cat disease. Theres no FIP test. A series of tests must be done to confirm an FIP/Feline Infectious Peritonitis diagnosis.
Feline Infectious Peritonitis or FIP is a fatal viral disease that creates a lot of fear and confusion in shelters. Find out information on the causes, transmissions, symptoms, and treatments.