muscle cell in human body human coronary artery smooth muscle cells 2 photo, muscle cell in human body human coronary artery smooth muscle cells 2 image, muscle cell in human body human coronary artery smooth muscle cells 2 gallery
These results show for the first time that the presence of atherosclerosis in human coronary arteries specifically augments contractions to cysteinyl leukotrienes and provides an enzymatic capacity within the vessel wall in the form of infiltrating macrophages and possibly smooth muscle cells to produce leukotrienes that could contribute to the hyperreactivity of atherosclerotic vessels. Hyperreactivity of human atherosclerotic coronary arteries to LTC4 and LTD4 was unaffected by endothelium-derived mediators. Previous reports29 have shown increased responsiveness of atherosclerotic arteries to serotonin that was unaffected by the endothelium. In those studies, hyperreactivity was reported to involve an increased responsiveness of the receptor or signal transduction system that was not apparent in the receptors present in the nondiseased arteries. Our present findings provide no evidence of cysteinyl leukotriene receptors in nonatherosclerotic epicardial coronary arteries, as suggested by the ...
Objective To visualize epicardial and intramyocardial coronary blood flow by using a noninvasive echocardiography system.. Methods In five juvenile swines, coronary flow imaging was used to visualize the different segments of epicardial coronary and intramyocardial arteries. Pulsed-Doppler spectrums were recorded and analyzed. The left anterior descending artery (LAD) and intramyocardial coronary blood flow signals were recorded at baseline and during dipyridamole administration.. Results Epicardial and intramyocardial coronary arteries could be visualized by coronary flow imaging. The systolic component of coronary flow in the right coronary artery (RCA) was greater than in the LAD. The intramyocardial blood flow was characterized by persistent retrograde blood flow velocity during systole. Vasodilation with dipyridamole produced exaggerated differences in the phasic pattern of coronary blood flow in epicardial and intramyocardial vessels.. Conclusion Color Doppler coronary flow imaging ...
The present study showed that ET-1 at small and physiological concentrations (10−11 mol/L) caused significant contraction in coronary smooth muscle cells with no detectable increases in [Ca2+]i. Although some studies have shown that picomolar concentrations of ET-1 increase [Ca2+]i in cultured human coronary smooth muscle cells,42 the present data are consistent with previous reports that these small ET-1 concentrations do not significantly increase [Ca2+]i in freshly isolated porcine coronary smooth muscle cells.32 The difference in the results could be related to differences in the cell preparation or the species studied. We should note that in the present study, [Ca2+]i was measured in an area of homogeneous fluorescence 1 μm in diameter, 1 μm from the plasma membrane, and 1 μm from the nucleus. Although small concentrations of ET-1 did not cause any detectable increases in [Ca2+]i in this representative part of the cell, small concentrations of PGF2α significantly increased [Ca2+]i in ...
B129 Mouse Coronary Artery Endothelial Cells from Creative Bioarray are isolated from coronary artery of pathogen-free laboratory B129S2/SvPasCrl mice. B129 Mouse Coronary Artery Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen. The method we use to isolate endothelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with PECAM-1 antibody, following the application of magnetic pre-coated with secondary antibody ...
Studies in animals with normal coronary arteries have shown that coronary flow reserve can be predicted by angiographic measurements of arterial stenosis. Studies in man, however, suggest that even quantitative analysis of coronary angiograms cannot predict the physiologic significance of individual coronary lesions. These studies, however, were carried out in patients with either widespread, diffuse coronary artery disease or by measurement techniques that tend to underestimate maximal coronary flow reserve. To determine the relationship between coronary arterial stenosis and coronary flow reserve (CFR) in patients with discrete limited coronary atherosclerosis, we studied 50 patients with a single discrete coronary stenosis in only one or two vessels. The minimum coronary arterial cross-sectional area (mCSA), percent area stenosis (%AS), and percent diameter stenosis in the left and right anterior oblique projections were determined by the Brown/Dodge method of quantitative coronary ...
OBJECTIVE--To assess whether the extent of LDL oxidation influences its cytotoxic effects, thus contributing to its atherogenic potential. DESIGN AND SETTING--The effects of native and modified LDL on cultured human coronary artery smooth muscle cells (SMC) and endothelial cells (ECs) were investigated. MAIN OUTCOME MEASURES--Four indices of cytotoxicity were studied: (i) chromium-51 release; (ii) 5-bromo-2-deoxyuridine (BrDUrd) uptake; (iii) morphological appearance; and (iv) EC migration. RESULTS--(i) Minimally modified (mm) LDL (400 micrograms/ml) causes significant 51Cr release; the cytotoxic effect was significantly greater for copper oxidised (ox) LDL (400 micrograms/ml). Native LDL had no effect. (ii) BrDUrd uptake studies showed significant inhibition of cell proliferation by 100 micrograms/ml of oxLDL and to a lesser extent by mmLDL; native LDL had no effect. (iii) Morphological appearance was not altered by native LDL. Changes in cell morphology were induced by mmLDL (400 ...
Several limitations of the present study must be considered. 1) Angiographically normal patients were included in the present study. Recently developed intravascular ultrasound has been reported [33]to demonstrate intimal thickening with a three-layered appearance in the normal coronary artery in vitro. Localized atherosclerotic lesions have been confirmed in angiographically minimally diseased coronary arteries by intravascular ultrasound in patients with focal vasospasm [34]. Diffuse concentric thickening of the coronary vessel wall might be demonstrated by intravascular ultrasound in patients with diabetes mellitus or diabetic retinopathy because in the present study, coronary diameters were significantly smaller in diabetic patients than in control patients, and minimally diseased coronary arteries ,25% were demonstrated by angiography in the left circumflex or right coronary artery in 5 patients. Such differences would be resolved by intravascular ultrasound. 2) Reduced coronary flow ...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human coronary artery smooth muscle cells (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative injury. GLP-1(28-36) modulates sAC by increasing intracellular ATP levels, with accompanying cAMP accumulation lost in sAC-/- cells. We identify mitochondrial trifunctional protein-α (MTPα) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate ...
Mechanisms mediating the cardioprotective actions of glucagon-like peptide 1 (GLP-1) were unknown. Here, we show in both ex vivo and in vivo models of ischemic injury that treatment with GLP-1(28-36), a neutral endopeptidase-generated (NEP-generated) metabolite of GLP-1, was as cardioprotective as GLP-1 and was abolished by scrambling its amino acid sequence. GLP-1(28-36) enters human coronary artery endothelial cells (caECs) through macropinocytosis and acts directly on mouse and human coronary artery smooth muscle cells (caSMCs) and caECs, resulting in soluble adenylyl cyclase Adcy10-dependent (sAC-dependent) increases in cAMP, activation of protein kinase A, and cytoprotection from oxidative injury. GLP-1(28-36) modulates sAC by increasing intracellular ATP levels, with accompanying cAMP accumulation lost in sAC-/- cells. We identify mitochondrial trifunctional protein-α (MTPα) as a binding partner of GLP-1(28-36) and demonstrate that the ability of GLP-1(28-36) to shift substrate ...
TY - JOUR. T1 - Deformationally dependent fluid transport properties of porcine coronary arteries based on location in the coronary vasculature. AU - Keyes, Joseph T.. AU - Lockwood, Danielle R.. AU - Simon, Bruce R.. AU - Geest, Jonathan P.Vande. PY - 2013/1. Y1 - 2013/1. N2 - Objective: Understanding coronary artery mass transport allows researchers to better comprehend how drugs or proteins move through, and deposit into, the arterial wall. Characterizing how the convective component of transport changes based on arterial location could be useful to better understand how molecules distribute in different locations in the coronary vasculature. Methods and results: We measured the mechanical properties and wall fluid flux transport properties of de-endothelialized (similar to post-stenting or angioplasty) left anterior descending (LADC) and right (RC) porcine coronary arteries along their arterial lengths. Multiphoton microscopy was used to determine microstructural differences. Proximal LADC ...
TY - JOUR. T1 - Protective effects of an indenoindole antioxidant on coronary endothelial function after long-term storage. AU - Wiklund, L.. AU - Miller, Virginia M. AU - McGregor, C. G A. AU - Sjoquist, P. O.. AU - Berggren, H.. AU - Nilsson, F.. PY - 1995. Y1 - 1995. N2 - Experiments were designed to evaluate function of the endothelium and smooth muscle of coronary arteries following storage of hearts in cardioplegia containing an inhibitor of lipid peroxidation (H 290/51, cis-7- metyl-9-methoxy-5,5a, 6,10b tetrahydroindeno [2,1-b] indole). Canine hearts were perfused with crystalloid cardioplegia (Plegisol, 15 ml/kg, 4°C) and left circumflex arteries were isolated and studied either immediately (group I, n=6), or after storage of the hearts at 4°C for 10 (group II, n=6) or 24 hr with (group III, n=6) or without (group IV, n=6) addition of H 290/51. The final concentration of H 290/51 was 1 μmol/L. Arteries were removed, cut into rings, and suspended in organ chambers for measurements of ...
Compared with the normal coronary arteries, significant alpha-adrenergic constriction of the stenotic coronary arteries can be induced by cardiac sympathetic nerve stimulation, resulting in the precipitation of myocardial ischemia with regional wall-motion abnormalities and net lactate production (26). In an experimental model, post-stenotic coronary vasoconstriction that was prevented by intravenous phentolamine or selective alpha2-blockade with rauwolscine in the absence as well as in the presence of acute beta-blockade was observed (26).. Under clinical conditions, sympathetic nerve activation may be induced by isometric as well as dynamic exercise, which may be involved in the narrowing of stenotic coronary arteries (4,5). This narrowing of the epicardial coronary segments can be prevented by administration of intracoronary nitroglycerin or the calcium-antagonist diltiazem, probably owing to the direct vasodilating properties of these two agents.. The precise mechanism responsible for ...
Definition of Circumflex coronary artery in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Circumflex coronary artery? Meaning of Circumflex coronary artery as a legal term. What does Circumflex coronary artery mean in law?
TY - JOUR. T1 - Enhancement of potassium induced relaxation of isolated coronary artery smooth muscle by adenosine. AU - Foley, D. H.. AU - Mason, D. T.. AU - Amsterdam, Ezra A. PY - 1975. Y1 - 1975. N2 - Local regulation of coronary blood flow may involve an interplay of the vasoactive properties of several metabolic factors. To evaluate the effect of adenosine (Ado) on K+ induced relaxation of vascular smooth muscle, helical strips of cat coronary arteries, suspended in an organ bath of Krebs solution (37° C, 95% O2 and 5% CO2), were studied during isometric contraction stimulated by acetylcholine (ACh). From a baseline concentration of 3.0 mM, a small increment in [K+] of 2 mM induced a 16.0 ± 2.7% relaxation of tension from the initial level. However, in the presence of Ado, which induced a 20.4 ± 3.0% relaxation of 29.7 ± 4.6%. The latter was significantly greater (P , 0.005) than the response in the absence of Ado. Similarly, a 4 mM [K+] increment elicited a 14.9 ± 3.0% relaxation ...
Recent evidence suggests that higher restenosis rate is observed after coronary angioplasty of an infarct-related artery. Furthermore, angiographic restenosis seems associated with a deterioration of left ventricular function at follow-up. The aim of this study was to assess the acute results and angiographic restenosis following coronary artery stenting of infarct-related (Group 1) and non infarct-related coronary arteries (Group 2). We retrospectively analyzed the results of 381 consecutive patients treated with Palmaz-Schatz coronary stent implantation between May 1992 and January 1996. Stenting of the infarct-related artery was performed in 154 patients (Group 1), while 227 patients (Group 2) received stenting of the non infarct-related artery. Both groups had similar age, gender, clinical conditions and coronary angiographic pattern. There were no significant differences between groups, concerning type of stented coronary vessel (left anterior descending-LAD 52.4% vs non-LAD 47.6%, Group 1, ...
Olivey H.E., Svensson E.C.. The establishment of the coronary circulation is critical for the development of the embryonic heart. Over the last several years, there has been tremendous progress in elucidating the pathways that control coronary development. Interestingly, many of the pathways that regulate the development of the coronary vasculature are distinct from those governing vasculogenesis in the rest of the embryo. It is becoming increasingly clear that coronary development depends on a complex communication between the epicardium, the subepicardial mesenchyme, and the myocardium mediated in part by secreted growth factors. This communication coordinates the growth of the myocardium with the formation of the coronary vasculature. This review summarizes our present understanding of the role of these growth factors in the regulation of coronary development. Continued progress in this field holds the potential to lead to novel therapeutics for the treatment of patients with coronary artery ...
TY - JOUR. T1 - Association of remodeling with endothelial shear stress, plaque elasticity, and volume in coronary arteries. T2 - A pilot coronary computed tomography angiography study. AU - Katranas, Sotirios A.. AU - Kelekis, Anastasios L.. AU - Antoniadis, Antonios P.. AU - Chatzizisis, Yiannis S.. AU - Giannoglou, George D.. PY - 2014/5. Y1 - 2014/5. N2 - We sought to noninvasively assess the relationship between arterial remodeling, endothelial shear stress (ESS), and wall stiffness in coronary arteries. We studied 28 coronary arteries from 22 patients undergoing coronary computed tomography angiography (CCTA). The ESS was calculated in 2-mm long segments using computational fluid dynamics. Local remodeling, plaque dimensions, and local wall stiffness were assessed in each segment. The ESS was lower in the regions of excessive expansive remodeling versus compensatory expansive versus inadequate expansive versus constrictive remodeling. Areas of decreased wall stiffness more frequently ...
TY - JOUR. T1 - In-vivo validation of spatially correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane angiography. AU - Giannoglou, George D.. AU - Chatzizisis, Yiannis S.. AU - Sianos, George. AU - Tsikaderis, Dimitrios. AU - Matakos, Antonis. AU - Koutkias, Vassilios. AU - Diamantopoulos, Panagiotis. AU - Maglaveras, Nicos. AU - Parcharidis, George E.. AU - Louridas, George E.. PY - 2006/9. Y1 - 2006/9. N2 - OBJECTIVES: The in-vivo validation of geometrically correct three-dimensional reconstruction of human coronary arteries by integrating intravascular ultrasound and biplane coronary angiography has not been adequately investigated. The purpose of this study was to describe the reconstruction method and investigate its in-vivo feasibility and accuracy. METHODS: In 17 coronary arteries (mean length, 85.7±17.1 mm) from nine patients, an intravascular ultrasound procedure along with a biplane coronary angiography was performed. ...
A coronary arterial fistula is a connection between 1 or more of the coronary arteries and a cardiac chamber or great vessel. This is a rare defect and usually occurs in isolation (1). We report a case of coronary arterial fistula with adjacent atherosclerotic plaque treated with a covered stent in a patient with non-ST-segment elevation myocardial infarction. This 59-year-old man had a medical history of type 2 diabetes mellitus and experienced severe chest tightness. A high serum troponin I level of 3.219 ng/ml was noted, and non-ST-segment elevation myocardial infarction was diagnosed. Coronary angiography showed 3 coronary arterial fistulae at the left main coronary artery proximal and mid left anterior descending coronary artery (Figure 1A). The stenotic lesion with haziness was noted at the mid left anterior descending coronary artery, and the biggest coronary arterial fistula stood aside (Figure 1B, Online Video 1). An intravascular ultrasound study showed severe stenosis with ...
Bovine Coronary Artery Endothelial Cells: BCAEC (Cryovial); find Sigma-Aldrich-B300-05 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich.
A number of studies have asserted that moderate drinking has a positive benefit on cardiovascular health. Now, scientists at the University of Rochester Medical Center have discovered how alcohol consumption can help to prevent heart disease. The research, published in the journal Arteriosclerosis, Thrombosis and Vascular Biology, studied the effects of moderate amounts of alcohol in human coronary artery smooth muscle cells and in the carotid arteries of mice [1]. In both cases, regular, limited amounts of alcohol inhibited a protein called Notch 1 and prevented the buildup of smooth muscle cells in blood vessels that leads to the narrowing of the arteries and can put you at risk for a heart attack or stroke.. ...
Coronary artery disease: A major cause of illness and death, coronary artery disease (CAD) begins when hard cholesterol substances (plaques) are deposited within a coronary artery. (The coronary arteries arise from the aorta adjacent to the heart and supply the heart muscle with blood that is rich in oxygen. They are called the coronary arteries because they encircle the heart in the manner of a crown.) The plaques in the coronary arteries can cause a tiny clot to form which can obstruct the flow of blood to the heart muscle producing symptoms and signs of CAD that may include: Chest pain (angina pectoris) from inadequate blood flow to the heart; Heart attack (acute myocardial infarction), from the sudden total blockage of a coronary artery; or Sudden death, due to a fatal disturbance of the heart rhythm. Common Misspellings: coronary artery diease, coronary artery desease ...
TY - JOUR. T1 - Role of potassium channels in coronary vasodilation. AU - Dick, Gregory M.. AU - Tune, Johnathan D.. PY - 2010/1/1. Y1 - 2010/1/1. N2 - K+ channels in coronary arterial smooth muscle cells (CASMC) determine the resting membrane potential (Em) and serve as targets of endogenous and therapeutic vasodilators. Em in CASMC is in the voltage range for activation of L-type Ca2+ channels; therefore, when K+ channel activity changes, Ca2+ influx and arterial tone change. This is why both Ca2+ channel blockers and K+ channel openers have such profound effects on coronary blood flow; the former directly inhibits Ca2+ influx through L-type Ca2+ channels, while the latter indirectly inhibits Ca2+influx by hyperpolarizing Em and reducing Ca2+ channel activity. K+ channels in CASMC play important roles in vasodilation to endothelial, ischemic and metabolic stimuli. The purpose of this article is to review the types of K+ channels expressed in CASMC, discuss the regulation of their activity by ...
Abstract: Systematic quantitative investigations were performed in the coronary arteries of 102 hearts of 36 mammal species with an overall more than tenthousandfold difference of their heart weight. After postmortem coronary angiography with a filling pressure of 100 mm Hg x-rays were taken, and the widest diameters of the coronary artery stems were determined. We found a nearly linear correlation between diameter of a standardized coronary artery and virtual diameter of heart, but the increase in diameter of coronary arteries exceeded somewhat that of the diameter of heart especially for heart weights surmounting 100 g. Perhaps relative enlargement of coronary arteries in the bigger hearts contributes to the prevention of large increase of blood flow velocity.. Keywords: Coronary artery diameter, Heart weight, Coronary blood flow Authors: J. W. Thüroff, W. Hort and H. Lichti. Journal: Basic Research in Cardiology. ...
2016 International Federation for Medical and Biological Engineering The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress ...
Coronary artery calcium (CAC) 0; Coronary artery calcium (CAC) 1-399; Coronary artery calcium (CAC) >=400; Coronary flow reserve (CFR) >=2.0; Coronary flow reserve (CFR ...
Both the right and left coronary artery ostia arise from their respective aortic sinuses. Both ostia are located more than half the distance between the sinotubular junction and aortic valve annulus (Fig. 2-1). The left main coronary artery originates with an elliptic ostium measuring approximately 3.2 ± 1.1 mm × 4.7 ± 1.2 mm.2 This coronary artery continues at an acute angle and travels parallel to the aortic sinus wall, coursing between the pulmonary artery and the left atrium in the region of the left atrial appendage. The length of the left main artery ranges from 0 mm (double-barrel ostium) to 20 mm. However, in most cases, the length of the left main coronary artery is between 6 and 15 mm, with an average diameter ranging from 3 to 6 mm.3 In two-thirds of cases, the left main coronary artery bifurcates into the left anterior descending (LAD) and circumflex arteries (Fig. 2-2); in one-third of cases, it trifurcates into the LAD artery, the circumflex artery, and a ramus intermedius ...
1. The consequences of the reduced production of nitric oxide (NO) by cells from regenerated endothelium were investigated by measuring membrane potential of smooth muscle cells (SMCs), isometric tension and cyclic nucleotides content in porcine coronary arteries with intimal thickening, four weeks following angioplasty. 2. Under basal conditions, SMCs of coronary arteries with regenerated endothelium were depolarized by 10 mV. This depolarization was associated with 82% decreased level of cGMP without alteration in cAMP. 3. Sodium nitroprusside (SNP, 1 μM) repolarized SMCs of the previously denuded coronary arteries. This repolarization was abolished by 1H-[1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 10 μM) and not suppressed by glibenclamide (10 μM), iberiotoxin (IbTX, 100 nM) and the combination of charybdotoxin (ChTX, 40 nM) plus apamin (100 nM). 4. Four-aminopyridine (4-AP, 1-5 mM) generated spontaneous rhythmic activities only in coronary arteries with regenerated endothelium which ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
The two main coronary arteries are the left main and right coronary arteries. The left main coronary artery (LMCA), which divides into the left anterior descending artery and the circumflex branch, supplies blood to the left ventricle and left atrium. The right coronary artery (RCA), which divides into the right posterior descending and acute marginal arteries, supplies blood to the right ventricle, right atrium, sinoatrial node (cluster of cells in the right atrial wall that regulates the hearts rhythmic rate), and atrioventricular node (AV node, a cluster of cells between the atria and ventricles that regulate the electrical current).. Additional arteries branch off the left main coronary artery to supply the left side of the heart muscle with blood. These include the following:. ...
Normal Human HUVEC Primary, 10-Donor Pool HUVEC, Aortic Endothelial, Aortic Smooth Muscle, Coronary Artery Endothelial, Coronary Artery Smooth Muscle Cells.
The current in vitro studies demonstrate an enhanced vasoconstrictor response of small coronary arteries to ET-1 and S6c in pigs with experimental hypercholesterolemia. This response is mediated mainly through the ETB receptor. These alterations in the coronary responsiveness occurred in the setting of long-term elevation of circulating ET-1. These studies support a role for both the ETA and ETB receptors in the regulation of coronary tone in the presence and absence of hypercholesterolemia.. Seo and colleagues12 previously demonstrated that the contractile response of porcine epicardial arteries to endothelins is biphasic; the first phase attained at low concentrations is primarily mediated by the endothelin ETB receptor, whereas both endothelin receptors mediate contraction in the latter, more pronounced phase attained at high concentrations. Takase and colleagues32 found similar results in noncoronary resistance vessels. The current studies extend these previous observations and demonstrate ...
I read with interest the manuscript by Ortiz-Pérez et al. (1) regarding the concordance between the 17-segment American Heart Association model (2) and coronary arterial anatomy using contrast-enhanced cardiac magnetic resonance imaging. In 93 subjects with an acute coronary syndrome, the investigators report a moderately good agreement between the actual and model-predicted coronary artery distribution and suggest that the inferior apical, lateral apical, and mid anterolateral segments are most commonly supplied by the left anterior descending coronary artery (LAD), contrary to what the model predicts.. In a previous study assessing the accuracy of a 17-segment model widely used in the nuclear cardiology literature, we projected the actual coronary artery anatomy of 135 patients undergoing coronary angiography onto the 17-segment model (3). We found that in general the model-predicted coronary anatomy was appropriate. There was only 1 segment (the apical lateral) in which the model-predicted ...
Looking for online definition of Anterior interventricular groove in the Medical Dictionary? Anterior interventricular groove explanation free. What is Anterior interventricular groove? Meaning of Anterior interventricular groove medical term. What does Anterior interventricular groove mean?
Looking for online definition of posterior interventricular vein in the Medical Dictionary? posterior interventricular vein explanation free. What is posterior interventricular vein? Meaning of posterior interventricular vein medical term. What does posterior interventricular vein mean?
TY - JOUR. T1 - Efficacy of coronary stenting versus balloon angioplasty in small coronary arteries. AU - Savage, Michael P.. AU - Fischman, David L.. AU - Rake, Randal. AU - Leon, Martin B.. AU - Schatz, Richard A.. AU - Penn, Ian. AU - Nobuyoshi, Masakiyo. AU - Moses, Jeffrey. AU - Hirshfeld, John. AU - Heuser, Richard. AU - Baim, Donald. AU - Cleman, Michael. AU - Brinker, Jeffrey. AU - Gebhardt, Sharon. AU - Goldberg, Sheldon. N1 - Funding Information: This study was supported in part by a grant from Johnson & Johnson Interventional Systems, Inc., Warren, New Jersey. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.. PY - 1998/2. Y1 - 1998/2. N2 - Objectives. The goal of this study was to compare the efficacy of elective stent implantation and balloon angioplasty for new lesions in small coronary arteries. Background. Palmaz-Schatz stents have been designed and approved by the Food and Drug Administration for use in coronary arteries with diameters ≤3.0 mm. The efficacy of ...
1. Binding sites for calcitonin-gene-related peptide were localized and characterized in porcine coronary arteries using quantitative autoradiography, and the density of binding sites was compared between large epicardial and small intramyocardial coronary arteries.. 2. A single class of binding sites for calcitonin-gene-related peptide with a dissociation constant of 2.1 ± 0.2 nmol/l was detected in both the large and small coronary arteries. The density of specific binding sites was higher (maximum binding site density 231 ± 14 fmol/mg of protein) in the small coronary arteries than in the large epicardial coronary arteries (maximum binding site density 108 ± 5 fmol/mg of protein). β-Human calcitonin-gene-related peptide showed higher affinity than α-human calcitonin-gene-related peptide for the binding sites. Most of the specific binding sites for both peptides in the large coronary artery were localized in the intima and media.. 3. In coronary artery from patients with coronary heart ...
To the best of our knowledge, this is the first reported case of percutaneous coronary intervention (PCI) on RCA ostial stenosis after re-do AVR. Coronary ostial stenosis after AVR is rare and occurs most often in the left main coronary artery, but the RCA can also be affected. An autopsy report revealed that thickened tissue in the aortic root and proximal coronary artery showed fibrosis and intimal thickening and no evidence of atherosclerosis on histological examination [1]. This phenomenon has been proposed to be due to turbulent flow around the prosthetic valve leading to obstruction of the coronary ostia. Fibrotic thickened tissue protrusion was also observed in our case, which was confirmed with homogeneous low echogenicity on IVUS.. Although the pathophysiological mechanism of coronary ostial stenosis after AVR is not well understood, various mechanisms could have mutually influenced this case according to previous studies. First, there could be micro-injury and local hyperplastic ...
The present study demonstrates the modulated expression of the adhesion molecule E-selectin via angiotensin II in human coronary endothelial cells. Evidence for this pathway was obtained from measurements of increased antigen expression at the protein level as well as from increased mRNA content. Functionally, the angiotensin II-induced expression of E-selectin leads to an increase of HL-60 cell adhesion, as demonstrated under near-physiological flow conditions. The effects of angiotensin II on E-selectin expression appear to be mediated by an AT1 (angiotensin II) receptor, since the AT1-receptor antagonist DUP 753 but not the AT2-receptor antagonist PD 123177 suppressed E-selectin-dependent adhesion. These observations indicate a link between the renin-angiotensin system and the expression of E-selectin, which is thought to play a crucial role in the processes of inflammation and atherosclerosis.1 26 27 Adhesion molecule expression on endothelial cells after stimulation with angiotensin II was ...
Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 Oct; 61(4):429-439. . View in PubMed. The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells Clin Exp Pharmacol Physiol. 2017 Apr; 44(4):480-487. . View in PubMed. Intermittent Reprogramming: A Breath of Fresh Air for Lung Regeneration Cell Stem Cell. 2017 12 07; 21(6):712-714. . View in PubMed. Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells J Biosci. 2016 Dec; 41(4):659-666. . View in PubMed. The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. . View in PubMed. Alterations of voltage-dependent K(+) channels in ...
The aim of this study was to perform a pilot histological and quantitative analysis of the blood vessels accompanying the epicardial nerves (vasa nervorum) in the porcine hearts. Twenty healthy porcine hearts were used in this study. The blood vessels were analyzed by light microscopy using four different staining techniques in transverse sections taken from the upper, middle, and lower segments of the anterior part of the interventricular region and the adjacent parts of the right and left ventricles containing epicardial nerves and the endocardial peripheral parts of the Purkinje fibers. In total, 317 epicardial nerves were detected. The vasa nervorum were present in 75.7% of these nerves. The vasa nervorum resembled arterioles and postcapillary and collecting venules. One hundred and forty nine epicardial nerves were perivascular, located in the adventitia of the anterior interventricular artery and vein. The remaining 168 nerves ran freely through the epicardial interstitium. The presence of ...
Coronary artery disease is a condition in which the coronary arteries are narrowed by deposits called plaques.. The coronary arteries originate from the aorta and supply blood and oxygen to your heart muscle allowing it pump blood to the body. Normal coronary arteries allow blood to flow freely. However, these arteries can become narrowed by inflammatory fatty deposits called plaques. This disease process is called atherosclerosis. Atherosclerosis that occurs in the coronary arteries is called coronary artery disease.. These plaques build up over time and can decrease the amount of oxygen reaching your heart. Mild coronary artery disease may develop over decades without any symptoms. More severe coronary artery disease can cause chest pain, called angina, and shortness of breath.. If a plaque suddenly ruptures, a blood clot can form and block the hearts blood supply. This is called a heart attack and it can cause permanent damage to the heart. Over time, severe coronary artery disease can also ...
Background. Experimental studies on the effects of alpha2-adrenoceptors on regional coronary blood flow in normal and ischemic myocardium are highly controversial. A beneficial effect on regional ischemic myocardium has been demonstrated in different animal preparations with either alpha2-adrenoceptor blockade or stimulation. Animal studies also demonstrated that postsynaptic alpha2-adrenoceptors mediate vasoconstriction in coronary and femoral vascular beds. The aims of the study were 1) to investigate the effects of regional alpha2-adrenoceptor stimulation on regional coronary blood flow in subjects with angiographically normal coronary arteries, 2) to assess the effect of alpha2-adrenoceptor blockade on coronary circulation in control subjects, and 3) to examine the influence of atherosclerosis on coronary blood flow response to alpha2-adrenoceptor blockade. Methods and Results. The effect of regional administration of BHT 933 (a selective alpha2-adrenoceptor agonist) was studied in eight ...
Previously we reported that the P2Y2 receptor (P2Y2R) is one of the predominant purinergic receptors expressed in human coronary artery endothelial cells (HCAEC), and that P2Y2R activation by ATP or UTP induces dramatic up-regulation of tissue factor (TF), key initiator of the coagulation cascade. However, the molecular mechanism of this P2Y2R-TF axis remains unclear. Here we report a role of a newly identified AP-1 consensus sequence along with its new binding components in P2Y2R regulation of TF transcription. We identified with bioinformatics tools that a novel AP-1 site at -1363 bp of human TF promoter region is highly conserved across multiple species. P2Y2R activation increased TF promoter activity and mRNA expression in HCAEC. Truncation, deletion, and mutation of this new distal AP-1 site all significantly supressed TF promoter activity in response to P2Y2R activation. EMSA and ChIP assays further confirmed that upon P2Y2R activation, c-Jun, ATF-2 and Fra-1, but not the typical c-Fos, ...
The effect of a new coronary vasodilator (Persantin), which produces a marked increase in coronary blood flow (up to 159 per cent in normal animals) without increasing cardiac contractility or cardiac work, has been studied in the experimental animal. This is associated with a marked decrease in coronary resistance. There is an increase in the coronary venous oxygen content and a decrease in the coronary A-V oxygen difference; the cardiac output is only slightly affected. Increase in the coronary blood flow has also been observed in dogs in which coronary in sufficiency has been produced by coronary ligation and by narrowing of the lumen of the coronary artery by the application of casein rings. This was accompanied by no significant increase in cardiac work.. ...
In this study, we investigate plaques located at the left coronary bifurcation. We focus on the effect that the resulting changes in wall shear stress (WSS) and wall pressure stress gradient (WPSG) have on atherosclerotic progress in coronary artery disease. Coronary plaques were simulated and placed at the left main stem and the left anterior descending to produce ,50% narrowing of the coronary lumen. Computational fluid dynamics analysis was carried out, simulating realistic physiological conditions that show the in vivo cardiac haemodynamic. WSS and WPSG in the left coronary artery were calculated and compared in the left coronary models, with and without the presence of plaques during cardiac cycles. Our results showed that WSS decreased while WPSG was increased in coronary side branches due to the presence of plaques. There is a direct correlation between coronary plaques and subsequent WSS and WPSG variations based on the bifurcation plaques simulated in the realistic coronary ...
To study the role of 320-detector coronary computed tomography angiography (CTA) in assessing native coronary arteries in patients treated with coronary stents. 123 patients with coronary stenting received both CTA and conventional coronary angiography (CCA) within 1 day. The clinical parameters, coronary calcium scoring, CTA and CCA were analyzed to determine the prevalence of significant stenosis of native coronary arteries (SSNCA), the predictive value of CTA and the factors correlating with SSNCA and newly developed SSNCA after stenting (NDSSNCAS), with CCA as the standard of reference, using both vessel-based analysis (VBA) and patient-based analysis (PBA). Both the source and the reconstructed images were analyzed by CTA. All native coronary arteries were interpretable independent of cardiac motion. CTA showed a sensitivity/specificity of 93.5 %/97.3 % and 92.5 %/92.5 % in diagnosing SSNCA in VBA and PBA, respectively. The significant factors related to SSNCA were higher calcium scores (P ...
The main goal of AIM III is to assess and quantify the effect of long-term administration of darapladib 160 mg once a day, a selective, reversible, orally active inhibitor of plasma and vascular Lp-PLA2, on coronary endothelial function, progression of coronary atherosclerosis as determined by intravascular ultrasound (IVUS), and atherosclerosis in patients with early atherosclerosis. Patients with evidence of coronary endothelial dysfunction, as determined by intracoronary administration of acetylcholine during angiography and IVUS, will be followed for 6 months during once daily dosing of darapladib. Coronary endothelial function is determined by the changes in coronary artery diameter and coronary blood flow response to the intracoronary administration of acetylcholine and adenosine. The patients will be followed in clinic 6 months. They will have follow-up angiography, assessment of endothelial function, and IVUS during the six month visit ...
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Although atherosclerosis is a systemic disease, plaque progression and complications occur in a focal, patchy pattern. It remains challenging to predict which segments of a given coronary artery will show accelerated progression of atherosclerosis.. Coronary endothelial dysfunction, characterized by a segmental vasoconstrictive response to the endothelium-dependent vasodilator acetylcholine, is considered the earliest stage of atherosclerosis in patients with angiographically nonobstructive coronary arteries. Therefore, sites with endothelial dysfunction may signal future progression of segmental coronary atherosclerosis (1). Using serial intravascular ultrasound (IVUS) imaging, we tested the hypothesis that coronary segments with endothelial dysfunction are associated with plaque progression in patients with nonobstructive coronary artery disease.. In this prospective study, 22 patients underwent coronary angiography with coronary endothelial function assessment and IVUS for clinical purposes ...
Thesis, English, Role of monocyte chemotactic protein 1|(mcp1)in diagnosis of patients with atherosclerotic coronary artery disease for Ebraheem Dalia El Morsy
Definitive diagnosis of coronary artery spasm often begins with a coronary angiogram that is performed with the expectation of finding atherosclerotic narrowing of a heart artery. Patients with coronary artery disease may have one or more plaques in their coronary arteries and unless the blockages are severe, there may be no symptoms. Two patients had coronary artery disease, and three had angiographically normal coronary arteries.. Acting fast at the first sign of heart attack symptoms can save your life and limit damage to your heart. Whether you have had a heart attack or not, if you feel depressed, tell your doctor. You can even have a silent heart attack, one with no symptoms. The symptoms of a heart attack can vary from person to person. To prevent a heart attack, you will most likely need to make lifestyle changes. The patient may need to be hospitalized to prevent a heart attack.. Without normal blood flow from the coronary arteries the heart becomes lack of oxygen and vital nutrients ...
5-hydroxytryptamine (5-HT)-induced coronary artery responses have both vasoconstriction and vasorelaxation components. The vasoconstrictive effects of 5-HT have been well studied while the mechanism(s) of how 5-HT causes relaxation of coronary arteries has been less investigated. In isolated rat hearts, 5-HT-induced coronary flow increases are partially resistant to the nitric oxide synthase inhibitor Nω-Nitro-L-arginine methyl ester (L-NAME) and are blocked by 5-HT7 receptor antagonists. In the present study, we investigated the role of 5-HT7 receptor in 5-HT-induced coronary flow increases in isolated rat hearts in the absence of L-NAME, and we also evaluated the involvement of endothelium-derived hyperpolarizing factor (EDHF) in 5-HT-induced coronary flow increases in L-NAME-treated hearts with the inhibitors of arachidonic acid metabolism and the blockers of Ca2+-activated K+ channels. In isolated rat hearts, 5-HT and the 5-HT7 receptor agonist 5-carboxamidotryptamine induced coronary flow
Objective: Streptococcus mutans is the leading cause of dental caries worldwide and a causative agent of infectious endocarditis. Collagen binding protein, Cnm, is expressed by about 10% of S.mutans clinical strains. Here, we investigate the role of Cnm in adherence, invasion, and persistence of human coronary artery smooth muscle cells (CASMC) in vitro. Methods: Adherence and Antibiotic Protection Assay: Human cells were infected with wildtype strains of S.mutans and their corresponding cnm mutants: OMZ175, OM50E, LM7, NCTC11060. S.mutans UA159, a natural cnm negative strain, was used as a negative control. For adherence, human cells were infected at MOI 100 and incubated for 30 min at 4oC. For invasion, human cells were infected at MOI 100 for 2 hours, washed, antibiotic treated for 3 hours to kill extracellular bacteria. Cells were lysed, serially diluted and plated on BHI, and CFUs determined. Quantitative PCR: Antibiotic protection assay with strain OMZ175 was completed, except cells were ...
TY - JOUR. T1 - Angina Due to Coronary Microvascular Disease in Hypertensive Patients without Left Ventricular Hypertrophy. AU - Brush, J. E.. AU - Cannon, R. O.. AU - Schenke, W. H.. AU - Bonow, R. O.. AU - Leon, M. B.. AU - Maron, B. J.. AU - Epstein, S. E.. PY - 1988/11/17. Y1 - 1988/11/17. N2 - When angina occurs in patients with hypertension, it is usually attributed to coronary artery disease or left ventricular hypertrophy. To determine the contribution of coronary microvascular abnormalities to angina in patients with hypertension, we evaluated hypertensive patients without coronary artery disease or left ventricular hypertrophy by measuring the coronary responses to rapid atrial pacing before and after administration of ergonovine. We compared 12 hypertensive patients who had pacing-induced angina with 13 normotensive subjects without such angina. The two groups had similar coronary flow (in the great cardiac vein) at rest; however, pacing increased coronary flow less in hypertensive ...
The bioavailability of nitric oxide (NO) in the human coronary circulation at rest and after acetylcholine (ACH)-induced vasodilation was investigated in 32 patients with angiographically normal coronary arteries. The effects of intracoronary L-NG monomethyl arginine (L-NMMA) were investigated at rest and after ACH, sodium nitroprusside, and adenosine. L-NMMA (64 mumol/min) increased resting coronary vascular resistance by 22% (P , 0.001), reduced distal epicardial coronary artery diameter by 12.6% (P , 0.001), and inhibited ACH-induced coronary epicardial and microvascular vasodilation. These effects were reversed with intracoronary L-arginine. L-NMMA did not inhibit dilation in response to sodium nitroprusside and adenosine. 23 patients were exposed to one or more coronary risk factors. The vasoconstrictor effect of L-NMMA on the epicardial and microvessels was greater in patients free of risk factors: Coronary vascular resistance was 36% higher in patients without risks, compared to 17% ...
Time resolved coronary vessel wall imaging using TRAPD successfully restored the negative polarity of lumen signal and enhanced lumen-wall contrast in the cine images in flow-phantom (Figure 1), and in both normal and subjects with coronary risk factors (Figure 2). The acquisition and utilization of the additional frames increased the cumulative success rate of acquiring at least one adequate-quality image from 76% in single-image acquisitions to over 90% when five frames were acquired. Utilizing multiple consecutive frames in calculations achieved more separation between the normals and patients mean wall thickness values, and with more precision demonstrated by a narrower standard deviation. The difference in vessel wall thickness between the two subject groups was statistically significant (p,0.05) when using TRAPD (1.07 mm vs. 1.46 mm; 36% increase) compared to single-frame DIR imaging (1.24 mm vs. 1.55 mm; 25% increase). ...
Problem statement: Stent thrombosis, which may occur even one year after stent implantation, is a drawback of Drug-Eluting Stents (DES). Among the variety of causes of stent thrombosis after DES implantation, coronary endothelial dysfunction manifested or exaggerated by DES implantation should not be overlooked. This review article summarizes previous reports on coronary endothelial dysfunction after DES implantation and/or coronary spasm and discusses the mechanism, clinical implications and prognosis. Although novel stents that do not impair endothelial function will most likely be developed in the near future, millions of patients have already undergone implantation of a first or second generation DES. Conclusion/Recommendations: Some studies have reported that a drug improves the impairment of endothelial function. On the other hand, no direct relationships between spasm and stent thrombosis after DES implantation have been reported. A larger study is warranted to clarify the clinical significance
Coronary artery disease is among the most common causes of disability and death. Often, by the time symptoms occur, the process may already be far advanced. Frequently,t he first symptom of coronary artery disease is heart attack and sudden death. Dangerous coronary artery disease may be present in individuals that are totally asymptomatic. A recent study showed that a family history of early-onset coronary artery disease (CAD) is associated with significant amounts of plaque in the coronary arteries apparently healthy patients.. Researchers demonstrated a significant amount of plaque present (coronary plaque burden) in apparently healthy middle-aged close relatives of individuals with early-onset of coronary artery disease. This study underscores the fact that asymptomatic patients may benefit from early cardiac screening and that is especially true for individuals with a family history of early-onset CAD may benefit from screening for subclinical atherosclerosis.. The Cardiac portion of the ...
Coronary artery disease is currently the leading cause of death and disability in the United States. Doctors have identified risk factors for treating and delaying cardiac disease, and testing has increasingly become more sophisticated. One of these tests that doctors order and assess carefully is the coronary artery calcium score, or CAC. While it is an independent predictor of coronary artery disease, the score is combined with information from conventional cardiac risk factors to provide very useful information.. In coronary artery disease, a fatty material called plaque narrows the coronary artery diameters and limits blood flow crossing the heart. This most common cause of heart disease in both women and men leads to chest pain, heart attack, arrhythmia, and in advanced cases, heart failure. Coronary artery calcium screening is done with an electron beam CT scan which looks for coronary calcium on the cardiac vessel walls. Calcification within the arteries can be one of the earliest signs ...
Coronary angiography (an-jee-OG-ra-fee) is a test that uses dye and special x rays to show the inside of your coronary arteries. The coronary arteries supply blood and oxygen to your heart. A material called plaque can build up on the inside walls of the coronary arteries and cause them to narrow. When this happens, its called coronary artery disease (CAD). This can prevent enough blood from flowing to your heart and can lead to angina (an-JI-nuh or AN-juh-nuh) (chest discomfort or pain) and heart attack. Coronary angiography shows if you have CAD. Most of the time, the coronary arteries cant be seen on an x ray. During coronary angiography, a special dye is injected into the bloodstream to make the coronary arteries show up on an x ray. To deliver the dye to your coronary arteries, a procedure called cardiac catheterization (KATH-e-ter-i-ZA-shun) is used. A long, thin, flexible tube called a catheter is put into a blood vessel in your arm, groin (upper thigh), or neck. The tube is then ...
Chest pain;Pulmonary vein thrombosis;Coronary artery stenosis;Syndrome X;64-MDCT Chest pain is a typical symptom of ischemic coronary artery diseases. Patients with ischemic coronary artery diseases typically have coronary artery stenosis, although approximately 10-20% of patients with angina pectoris have normal coronary artery, and most of these patients are syndrome X that showed slow coronary flow [1] ; [2]. In addition, patients with chest pain but with an intact coronary artery stenosis were reported [3] ; [4]. Although occlusion of the small coronary arteries has been suggested as a cause of chest pain and atherosclerosis [5], the origin of the microclots that cause coronary artery occlusions remains unknown. Pulmonary vein thrombosis was hypothesized to be a rare complication associated with lung cancers and thoracic surgeries; however, since 2012, I have published several cases of pulmonary vein thrombosis in elderly patients with chest pain using a 64-slice multidetector CT (64-MDCT) ...
TY - JOUR. T1 - Preserved coronary arteriolar dilatation in patients with type 2 diabetes mellitus. T2 - Implications for reactive oxygen species. AU - Bagi, Zsolt. AU - Feher, Attila. AU - Beleznai, Timea. PY - 2009/1/1. Y1 - 2009/1/1. N2 - Type 2 diabetes mellitus is associated with clustering of cardiovascular risk factors that may greatly increase individuals risk of developing coronary artery disease. Type 2 diabetes is believed to impair coronary function. However, its impact on the vasomotor function of coronary resistance vessels in humans is still debated. Reduced, preserved or even augmented dilations of coronary arterioles have been reported in subjects with type 2 diabetes. Interestingly, recent studies have suggested that reactive oxygen species (ROS), particularly hydrogen peroxide, may compensate for the loss of the vasodilatory function of coronary microvessels during disease development. Recent interventional clinical trials have yielded largely negative results, and there has ...
Previous studies have shown that traditional risk factors such as hypercholesterolemia and hypertension account for only a small proportion of the dramatically increased risk of atherosclerotic coronary artery disease (CAD) in systemic lupus erythematosus (SLE). However, in these studies, exposure to risk factors was measured only at baseline. In this study, our objective was to compare measures of cumulative exposure with remote and recent values for each of total cholesterol (TC), systolic (SBP), and diastolic (DBP) blood pressure in terms of ability to quantify risk of atherosclerotic CAD in patients with SLE. Patients in the Toronto lupus cohort had TC and BP measured at each clinic visit and were followed up prospectively for the occurrence of CAD. For each patient, arithmetic mean, time-adjusted mean (AM) and area-under-the-curve (AUC) were calculated for serial TC, SBP, and DBP measurements. Proportional hazards regression models were used to compare these summary measures with recent and first
ReportsnReports.com adds 2014 Research Report on Global and China Coronary Stent Industry report to its research database.. This is a professional and depth research report on Global and China Coronary Stent Industry. Firstly the report describes the background knowledge of Coronary Stent, including Coronary Stent Concepts Classification production process technical parameters; then statistics Global and China 18 Manufacturers Coronary Stent product 2009-2017 Capacity production cost price production value Gross margins and other relevant data, statistics these enterprises Coronary Stent products, customers, raw materials, company background information, then summary statistics and analysis the relevant data of these enterprises. and get Global and China Coronary Stent 2009-2017 production market share, different regions and Type Coronary Stent production market share, Global and China Coronary Stent demand supply and shortage, Global and China Coronary Stent 2009-2017 production price cost ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Coronary Artery Calcium Imaging and Scoring (CAC Score). Coronary artery calcium (CAC) scoring is an easy, convenient, painless, non-invasive imaging technique to detect and evaluate the amount of calcium deposition in the coronary arteries (i.e. blood vessels supplying the heart muscle). It gives an idea of whether early cholesterol plaque have begun to infiltrate the coronary arteries despite the lack of any symptoms and will likely to progress in the years to come.. The degree of calcium deposition corresponds to the severity of the atheromatous plaque and the likelihood of a heart attack (see table 1). The higher the calcium score, the greater the risk and is used by cardiologists as one of the tools to assess and correlate with the risk of adverse cardiovascular events. Although not directly correlated - the higher the calcium score (termed the calcium burden), the greater the chance of more severe narrowing of the coronary arteries. Conversely a low calcium score although suggests a low ...
TY - JOUR. T1 - Diastolic coronary resistance and capacitance are independent of the duration of diastole. AU - Judd, R. M.. AU - Redberg, D. A.. AU - Mates, R. E.. PY - 1991. Y1 - 1991. N2 - Systolic myocardial contraction may produce changes in coronary resistance and capacitance that persist throughout a normal diastole. In addition, coronary resistance and capacitance as determined in the arrested heart may not accurately describe normal diastolic behavior. To evaluate these possibilities, an identification method capable of characterizing the input impedance of the coronary circulation in as little as 150 ms was developed. Using this method, coronary dynamics were measured during early and late diastoles in the beating heart with tone intact as well as during adenosine-induced maximal vasodilation. Coronary dynamics were also measured in the arrested heart during maximal vasodilation. With vasomotor tone intact, the parameters of a lumped model of the coronary circulation showed no ...
2] Coronary sinus ASDs are believed to arise from developmental failure of formation of the wall between the coronary sinus and the left atrium.. The coronary sinus is a systemic venous structure embryologically derived primarily from the left common cardinal vein that is continuous with the left anterior cardinal vein. Coronary sinus ASDs involve the inferior and anterior interatrial septa at the usual location of the orifice of the coronary sinus. The orifice of the coronary sinus becomes continuous with the left atrial chamber when a defect occurs in the wall separating the left atrium from the coronary sinus. This arrangement allows shunting between the atria.. From the right atrial aspect of the interatrial septum, the defect may consist of the coronary sinus orifice alone or with additional deficiency of atrial septal tissue around the coronary sinus orifice. On the left atrial side, the defect consists of partial or complete unroofing of the coronary sinus, if the entire superior aspect ...
Acute coronary obstruction occurred in two patients during coronary angiography. In one case the obstruction was in the left main coronary artery; in the other it was close to the origin of the left anterior descending artery. In both cases acute cardiac ischaemia ensued, with electromechanical dissociation and collapse, which was not reversible by resuscitation. Rapid disobliteration of the occluded coronary artery was done with a guide-wire pushed through the obstruction via the coronary catheter. The recanalisation was completed by an intracoronary perfusion of streptokinase in one case. In both cases recovery was rapid and spectacular. The occurrence of acute ischaemia during coronary angiography should suggest accidental coronary occlusion. If a thromboembolic origin is suspected, transluminal disobliteration should be attempted. It is simple and can reverse a dangerous condition ...
A coronary stent is a tubular structured device made of a thin mesh of wire, which may also be coated with a polymer containing a drug, or made of biodegradable materials. Coronary stents are utilized during percutaneous coronary interventions (PCIs) for the treatment of patients suffering from various coronary artery diseases (CADs) such as acute myocardial infarction, angina pectoris and others. At present, several researches are being conducted in the field of coronary stenting, in order to minimize side effects such as restenosis and thrombosis. Certain new and advanced coronary stents such as bio-absorbable stents have been commercialized in the global market, which demonstrate very less or no common side effects of coronary stenting.. Request a Sample Copy of the Report @ http://www.mrrse.com/sample/1170. The market for coronary stents can be broadly classified into three major segments, namely, bare metal stents (BMS), drug eluting stents (DES) and bio-absorbable stents. In 2011, the drug ...
Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management.
TY - GEN. T1 - Computational fluid dynamics analysis of the effect of simulated plaques in the left coronary artery. T2 - A preliminary study. AU - Chaichana, Thanapong. AU - Jewkes, James. AU - Sun, Zhonghua. PY - 2011. Y1 - 2011. N2 - Background: Atherosclerosis is the most common cause of coronary artery disease which is formed by plaque presence inside the artery wall leading to blockage of the blood supply to the heart muscle. The mechanism of atherosclerotic development is dependent on the blood flow variations in the artery wall during cardiac cycles. Characterization of plaque components and investigation of the plaques with subsequent coronary artery stenosis and myocardial dysfunction has been extensively studied in the literature. However, little is known about the effect of plaques on hemodynamic changes to the coronary artery, to the best of our knowledge. Investigation of the position of plaques in the coronary artery and its corresponding regional hemodynamic effects will provide ...